{
    "uniprot_canonical_ac": "A0A0G2KB06-1",
    "uniprot_ac": "A0A0G2KB06",
    "uniprot_id": "A0A0G2KB06_RAT",
    "mass": {
        "chemical_mass": 41387.0,
        "monoisotopic_mass": 41387.0
    },
    "refseq": {
        "ac": "NP_001103002",
        "name": "mitogen-activated protein kinase 11",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
    },
    "gene_names": [
        {
            "name": "Mapk11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KB06",
            "id": "A0A0G2KB06"
        },
        {
            "name": "Mapk11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002",
            "id": "NP_001103002"
        },
        {
            "name": "p38beta",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002",
            "id": "NP_001103002"
        }
    ],
    "protein_names": [
        {
            "name": "Mitogen-activated protein kinase 11",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB06/entry#names_and_taxonomy",
            "id": "A0A0G2KB06"
        },
        {
            "name": "mitogen-activated protein kinase 11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002",
            "id": "NP_001103002"
        }
    ],
    "function": [
        {
            "annotation": "Data indicate a functionally active mitochondrial pool of p38beta mitogen activated protein kinase (p38beta MAPK), and that this kinase phosphorylates manganese superoxide dismutase (MnSOD) in an 17beta-estradiol (E2)-dependent manner. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                },
                {
                    "database": "PubMed",
                    "id": "24465521",
                    "url": "https://glygen.org/publication/PubMed/24465521"
                }
            ]
        },
        {
            "annotation": "Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                },
                {
                    "database": "PubMed",
                    "id": "22157753",
                    "url": "https://glygen.org/publication/PubMed/22157753"
                }
            ]
        },
        {
            "annotation": "The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                },
                {
                    "database": "PubMed",
                    "id": "34814904",
                    "url": "https://glygen.org/publication/PubMed/34814904"
                }
            ]
        },
        {
            "annotation": "Unique ceramide signaling in ischemic and preconditioned hearts involving lipid rafts, which generated a survival signal by differentially associating the p38MAPKalpha and p38MAPKbeta with the caveolin-1 and caveoli-3",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                },
                {
                    "database": "PubMed",
                    "id": "17069850",
                    "url": "https://glygen.org/publication/PubMed/17069850"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:14330",
            "recommended_name": {
                "id": "DOID:14330",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:14330",
                "name": "Parkinson's disease",
                "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions."
            },
            "synonyms": [
                {
                    "id": "DOID:14330",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:14330",
                    "name": "Parkinson disease",
                    "description": ""
                },
                {
                    "id": "DOID:14330",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:14330",
                    "name": "paralysis agitans",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late-onset Parkinson disease",
                    "description": "A Parkinson disease that begins after around the age of 50."
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "LOPD",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "PARK",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "PD",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, age of onset, modifier, Multifactorial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, late-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, susceptibility to, Multifactorial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "autosomal dominant late-onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "hereditary late onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "hereditary late-onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late onset Parkinson's disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late-onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MIM:168600",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/168600",
                    "name": "Parkinson disease",
                    "description": "Parkinson disease"
                }
            ],
            "evidence": [
                {
                    "id": "14330",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:14330"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2KB06",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                }
            ],
            "common_name": "Rat",
            "glygen_name": "Rat",
            "reference_species": "Rattus norvegicus [10116]"
        }
    ],
    "gene": [
        {
            "name": "Mapk11",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KB06",
            "locus": {
                "chromosome": "7",
                "start_pos": 120218478,
                "end_pos": 120225395,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000006984",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000006984"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A0G2KB06",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2KB06",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "ENSRNOG00000006984",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006984",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "689314",
            "url": "https://www.ncbi.nlm.nih.gov/gene/689314",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000719",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003527",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003527",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008352",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008352",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011009",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017441",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR050117",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR050117",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:689314",
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:689314",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MDIPRPE",
            "url": "https://omabrowser.org/oma/group/MDIPRPE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A0G2KB06",
            "url": "https://www.orthodb.org/?gene=A0A0G2KB06",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "D4A3U7",
            "url": "https://www.orthodb.org/?gene=D4A3U7",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24055",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24055",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24055:SF109",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24055:SF109",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00069",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-168638",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168638",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-171007",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-171007",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-198753",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198753",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2559580",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-4420097",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4420097",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-450302",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450302",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-450341",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450341",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-525793",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-525793",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5668599",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668599",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-6804756",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001103002",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1309340",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309340",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2KB06",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KB06",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2KB06-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KB06-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6G769",
            "url": "https://www.uniprot.org/uniprot/A0A8I6G769",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6G769-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6G769-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A3U7",
            "url": "https://www.uniprot.org/uniprot/D4A3U7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D4A3U7-1",
            "url": "https://www.uniprot.org/uniprot/D4A3U7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLETSQLPGTHEIEQ",
        "length": 364,
        "header": "tr|A0A0G2KB06-1|A0A0G2KB06_RAT Isoform 1 of Mitogen-activated protein kinase 11  OS=Rattus norvegicus OX=10116 GN=Mapk11 PE=4 SV=1 CANONICAL=A0A0G2KB06-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2KB06-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB06/entry#A0A0G2KB06-1",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLETSQLPGTHEIEQ",
                "length": 364,
                "header": "tr|A0A0G2KB06-1|A0A0G2KB06_RAT Isoform 1 of Mitogen-activated protein kinase 11  OS=Rattus norvegicus OX=10116 GN=Mapk11 PE=4 SV=1 CANONICAL=A0A0G2KB06-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 120225309,
                "end_pos": 120219661,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000079777.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000079777.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000075602.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000075602.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6G769-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB06/entry#A0A8I6G769-1",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPGPARTCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLETSQLPGTHEIEQ",
                "length": 360,
                "header": "tr|A0A8I6G769-1|A0A8I6G769_RAT Computationally mapped isoform of Mitogen-activated protein kinase 11  OS=Rattus norvegicus OX=10116 GN=Mapk11 PE=4 SV=1 CANONICAL=A0A0G2KB06-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 120225309,
                "end_pos": 120219661,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000104992.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000104992.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000080828.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000080828.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D4A3U7-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB06/entry#D4A3U7-1",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVWSHPGPPHSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLETSQLPGTHEIEQ",
                "length": 371,
                "header": "tr|D4A3U7-1|A0A0G2KB06_RAT Computationally mapped isoform of Mitogen-activated protein kinase 11  OS=Rattus norvegicus OX=10116 GN=Mapk11 PE=4 SV=2 CANONICAL=A0A0G2KB06-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 120225309,
                "end_pos": 120219661,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000009325.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000009325.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000009325.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000009325.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart.",
            "journal": "Journal of molecular and cellular cardiology",
            "date": "2007",
            "authors": "Das M, Cui J, Das DK",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17069850",
                    "url": "https://glygen.org/publication/PubMed/17069850"
                }
            ]
        },
        {
            "title": "Regulation of sodium iodide symporter gene expression by Rac1/p38beta mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.",
            "journal": "The Journal of biological chemistry",
            "date": "2012",
            "authors": "Kogai T, Liu YY, Mody K, Shamsian DV, Brent GA",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22157753",
                    "url": "https://glygen.org/publication/PubMed/22157753"
                }
            ]
        },
        {
            "title": "Mitochondrial p38beta and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes.",
            "journal": "PloS one",
            "date": "2014",
            "authors": "Liu H, Yanamandala M, Lee TC, Kim JK",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24465521",
                    "url": "https://glygen.org/publication/PubMed/24465521"
                }
            ]
        },
        {
            "title": "The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.",
            "journal": "BMC endocrine disorders",
            "date": "2021",
            "authors": "Wang S, Wang A, Zhang Y, Zhu K, Wang X, Chen Y, Wu J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103002",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103002"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34814904",
                    "url": "https://glygen.org/publication/PubMed/34814904"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:689314",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:689314",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-168638",
            "name": "NOD1/2 Signaling Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168638",
            "resource": "Reactome",
            "description": "NOD1/2 Signaling Pathway"
        },
        {
            "id": "R-RNO-171007",
            "name": "p38MAPK events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-171007",
            "resource": "Reactome",
            "description": "p38MAPK events"
        },
        {
            "id": "R-RNO-198753",
            "name": "ERK/MAPK targets",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198753",
            "resource": "Reactome",
            "description": "ERK/MAPK targets"
        },
        {
            "id": "R-RNO-2559580",
            "name": "Oxidative Stress Induced Senescence",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580",
            "resource": "Reactome",
            "description": "Oxidative Stress Induced Senescence"
        },
        {
            "id": "R-RNO-4420097",
            "name": "VEGFA-VEGFR2 Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4420097",
            "resource": "Reactome",
            "description": "VEGFA-VEGFR2 Pathway"
        },
        {
            "id": "R-RNO-450302",
            "name": "activated TAK1 mediates p38 MAPK activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450302",
            "resource": "Reactome",
            "description": "activated TAK1 mediates p38 MAPK activation"
        },
        {
            "id": "R-RNO-450341",
            "name": "Activation of the AP-1 family of transcription factors",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450341",
            "resource": "Reactome",
            "description": "Activation of the AP-1 family of transcription factors"
        },
        {
            "id": "R-RNO-525793",
            "name": "Myogenesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-525793",
            "resource": "Reactome",
            "description": "Myogenesis"
        },
        {
            "id": "R-RNO-5668599",
            "name": "RHO GTPases Activate NADPH Oxidases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668599",
            "resource": "Reactome",
            "description": "RHO GTPases Activate NADPH Oxidases"
        },
        {
            "id": "R-RNO-6804756",
            "name": "Regulation of TP53 Activity through Phosphorylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756",
            "resource": "Reactome",
            "description": "Regulation of TP53 Activity through Phosphorylation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A286ZJZ3-1",
            "protein_name": "Mitogen-activated protein kinase 11",
            "gene_name": "MAPK11",
            "tax_id": 9823,
            "organism": "Sus scrofa",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDTRLRQRVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARAYIQSLPPVPQKDLRSIFRGANPLAVDLLGRMLVLDSDQRVSAAEALSHAYFSQYHDPEDEPEAEPYDESIEAKERTAEEWKELTYQEVLSFKPPEPPRPPGSLEVEQ",
                "length": 364
            },
            "evidence": [
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Pig",
            "common_name": "Pig"
        },
        {
            "uniprot_canonical_ac": "A0A8V0XC96-1",
            "protein_name": "Mitogen-activated protein kinase 11",
            "gene_name": "MAPK11",
            "tax_id": 9031,
            "organism": "Gallus gallus",
            "sequence": {
                "sequence": "MSERGGFYRQELNKTVWEVPQRYQNLTPVGSGAYGSVCSAYDTKTRQKVAVKKLSRPFQSLIHARRTYRELRLLKHMKHENVIGLLDVFTPATSIENFNEVYLVTNLMGADLNNIVKCQKLTDDHIQFLIYQLLRGLKYIHSAGIIHRDLKPSNLAVNEDCELRILDFGLARQTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLKGKALFPGDDYIDQLKRIMEVVGTPSSELLKKISSEHARKYIESLPHMPQQDLKAVFRGANPLAVDLLEKMLILDSDKRITASAALAHPYFVQYHDPDDEPEAELYDESIENKERTIEEWKELTYEEVMSFKPPDLKMDSLEIEQ",
                "length": 361
            },
            "evidence": [
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Chicken",
            "common_name": "Chicken"
        },
        {
            "uniprot_canonical_ac": "G3X793-1",
            "protein_name": "Mitogen-activated protein kinase 11",
            "gene_name": "MAPK11",
            "tax_id": 9913,
            "organism": "Bos taurus",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTLWEVPQRLQGLRPVGSGAYGSVCSAYDTRLRQRVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATALEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLRSIFRGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTVEEWKELTYQEVLSFKPPEPPQPLGSLDVEQ",
                "length": 364
            },
            "evidence": [
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Bovine",
            "common_name": "Bovine"
        },
        {
            "uniprot_canonical_ac": "Q00772-1",
            "protein_name": "Mitogen-activated protein kinase SLT2/MPK1",
            "gene_name": "SLT2",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MADKIERHTFKVFNQDFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHPYLSIWHDPADEPVCSEKFEFSFESVNDMEDLKQMVIQEVQDFRLFVRQPLLEEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGNAAASEENYPKQMATSNSVAPQQESFGIHSQNLPRHDADFPPRPQESMMEMRPATGNTADIPPQNDNGTLLDLEKELEFGLDRKYF",
                "length": 484
            },
            "evidence": [
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Yeast",
            "common_name": "Baker's yeast"
        },
        {
            "uniprot_canonical_ac": "Q15759-1",
            "protein_name": "Mitogen-activated protein kinase 11",
            "gene_name": "MAPK11",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ",
                "length": 364
            },
            "evidence": [
                {
                    "id": "47561967",
                    "url": "http://www.informatics.jax.org/homology/47561967",
                    "database": "MGI"
                },
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q39026-1",
            "protein_name": "Mitogen-activated protein kinase 6",
            "gene_name": "MPK6",
            "tax_id": 3702,
            "organism": "Arabidopsis thaliana",
            "sequence": {
                "sequence": "MDGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQQ",
                "length": 395
            },
            "evidence": [
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Arabidopsis",
            "common_name": "Mouse-ear cress"
        },
        {
            "uniprot_canonical_ac": "Q54QB1-1",
            "protein_name": "Extracellular signal-regulated kinase 2",
            "gene_name": "erkB",
            "tax_id": 44689,
            "organism": "Dictyostelium discoideum",
            "sequence": {
                "sequence": "MSSEDIDKHVLRKYEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMETDLHAVIRAKILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCILGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFVTQFHNPAEEPHFDRIIKISIDDGQKFPIAEYRNRLYNDIIKKKKEERKKQTNPTKPDTTAPTLST",
                "length": 369
            },
            "evidence": [
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Cellular slime mold",
            "common_name": "Social amoeba"
        },
        {
            "uniprot_canonical_ac": "Q9WUI1-1",
            "protein_name": "Mitogen-activated protein kinase 11",
            "gene_name": "Mapk11",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTHEIEQ",
                "length": 364
            },
            "evidence": [
                {
                    "id": "47561967",
                    "url": "http://www.informatics.jax.org/homology/47561967",
                    "database": "MGI"
                },
                {
                    "id": "A0A0G2KB06",
                    "url": "https://omabrowser.org/oma/group/A0A0G2KB06/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 15,
                "go_terms": [
                    {
                        "name": "cellular response to UV-B",
                        "id": "GO:0071493",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071493",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of gene expression",
                        "id": "GO:0010628",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular signal transduction",
                        "id": "GO:0035556",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "MAPK cascade",
                        "id": "GO:0000165",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "bone development",
                        "id": "GO:0060348",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "stress-activated protein kinase signaling cascade",
                        "id": "GO:0031098",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031098",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "osteoblast differentiation",
                        "id": "GO:0001649",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "stress-activated MAPK cascade",
                        "id": "GO:0051403",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051403",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to interleukin-1",
                        "id": "GO:0071347",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071347",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cardiac muscle cell proliferation",
                        "id": "GO:0060038",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060038",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of cardiac muscle cell proliferation",
                        "id": "GO:0060044",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060044",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cardiac muscle cell proliferation",
                        "id": "GO:0060043",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060043",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of interleukin-12 production",
                        "id": "GO:0032735",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032735",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "p38MAPK cascade",
                        "id": "GO:0038066",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038066",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to virus",
                        "id": "GO:0098586",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "protein serine/threonine kinase activity",
                        "id": "GO:0004674",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2KB06",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2KB06"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "MAP kinase activity",
                        "id": "GO:0004707",
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                "name": "Cellular Component",
                "total": 3,
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            "name": "isoformset.uniprotkb",
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        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
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        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
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    "sequence_features": {
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        "glycation_sites": [],
        "phosphorylation_sites": [],
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}
