{ "uniprot_canonical_ac": "A0A0G2K7L2-1", "uniprot_ac": "A0A0G2K7L2", "uniprot_id": "A0A0G2K7L2_RAT", "mass": { "chemical_mass": 134127.0, "monoisotopic_mass": 134127.0 }, "refseq": {}, "gene_names": [ { "name": "Igsf3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2", "id": "A0A0G2K7L2" } ], "protein_names": [ { "name": "Immunoglobulin superfamily, member 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7L2/entry#names_and_taxonomy", "id": "A0A0G2K7L2" } ], "function": [], "disease": [ { "disease_id": "DOID:13929", "recommended_name": { "id": "DOID:13929", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13929", "name": "lacrimal duct obstruction", "description": "" }, "synonyms": [ { "id": "DOID:13929", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13929", "name": "Blocked lacrimal canaliculus", "description": "" }, { "id": "DOID:13929", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13929", "name": "Obstruction of lacrimal canaliculus", "description": "" }, { "id": "DOID:13929", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13929", "name": "Obstruction of lacrimal ducts", "description": "" } ], "evidence": [ { "id": "13929", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13929" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Igsf3", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2", "locus": { "chromosome": "2", "start_pos": 188899645, "end_pos": 188811380, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000023851", "url": "https://www.ensembl.org/id/ENSRNOG00000023851" } ] } } ], "crossref": [ { "id": "A0A0G2K7L2", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K7L2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000023851", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000023851", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00099", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00099", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "295325", "url": "https://www.ncbi.nlm.nih.gov/gene/295325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:295325", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:295325", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QMIGERH", "url": "https://omabrowser.org/oma/group/QMIGERH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K7L2", "url": "https://www.orthodb.org/?gene=A0A0G2K7L2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1LZ40", "url": "https://www.orthodb.org/?gene=F1LZ40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12207:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12207:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_006233105", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233105", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1307796", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307796", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K7L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K7L2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AJX2", "url": "https://www.uniprot.org/uniprot/A0A8I6AJX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AJX2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AJX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LZ40", "url": "https://www.uniprot.org/uniprot/F1LZ40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LZ40-1", "url": "https://www.uniprot.org/uniprot/F1LZ40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCFFPVLSCLAVLGAVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPAEQNFQWSIYLPSAPEREVQIVSTVDSSFPYAIYTQRVRGGKIYVERIQGNSALLHITDLQARDAGEYECHTPNTDERYFGSYSAKMNLVVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETLQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREAKGQLKVAKEGDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLKSSMSVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTVQPGSSYWERSSYGGIQMEQVQPNSFSLGIFSSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRPIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQAQGSLSILETRQIQLECVVLNRTSMASQLVVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHVESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLLSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKATFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEVSEEEASEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKGWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1190, "header": "tr|A0A0G2K7L2-1|A0A0G2K7L2_RAT Isoform 1 of Immunoglobulin superfamily, member 3 OS=Rattus norvegicus OX=10116 GN=Igsf3 PE=4 SV=1 CANONICAL=A0A0G2K7L2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K7L2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7L2/entry#A0A0G2K7L2-1", "sequence": { "sequence": "MKCFFPVLSCLAVLGAVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPAEQNFQWSIYLPSAPEREVQIVSTVDSSFPYAIYTQRVRGGKIYVERIQGNSALLHITDLQARDAGEYECHTPNTDERYFGSYSAKMNLVVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETLQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREAKGQLKVAKEGDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLKSSMSVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTVQPGSSYWERSSYGGIQMEQVQPNSFSLGIFSSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRPIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQAQGSLSILETRQIQLECVVLNRTSMASQLVVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHVESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLLSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKATFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEVSEEEASEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKGWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1190, "header": "tr|A0A0G2K7L2-1|A0A0G2K7L2_RAT Isoform 1 of Immunoglobulin superfamily, member 3 OS=Rattus norvegicus OX=10116 GN=Igsf3 PE=4 SV=1 CANONICAL=A0A0G2K7L2-1" }, "locus": { "chromosome": "2", "start_pos": 188896272, "end_pos": 188812796, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080176.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080176.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074253.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074253.1" } ] } }, { "isoform_ac": "A0A8I6AJX2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7L2/entry#A0A8I6AJX2-1", "sequence": { "sequence": "MKCFFPVLSCLAVLGAVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPAEQNFQWSIYLPSAPEREVQIVSTVDSSFPYAIYTQRVRGGKIYVERIQGNSALLHITDLQARDAGEYECHTPNTDERYFGSYSAKMNLVVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETLQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREAKGQLKVAKEGDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLTDNWVVKVPQQHQILPQGHLESSMSVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTVQPGSSYWERSSYGGIQMEQVQPNSFSLGIFSSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRPIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQAQGSLSILETRQIQLECVVLNRTSMASQLVVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHVESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLLSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKATFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEVSEEEASEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKGWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1210, "header": "tr|A0A8I6AJX2-1|A0A8I6AJX2_RAT Computationally mapped isoform of Immunoglobulin superfamily, member 3 OS=Rattus norvegicus OX=10116 GN=Igsf3 PE=4 SV=1 CANONICAL=A0A0G2K7L2-1" }, "locus": { "chromosome": "2", "start_pos": 188896272, "end_pos": 188812796, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112581.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112581.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093223.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093223.1" } ] } }, { "isoform_ac": "F1LZ40-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7L2/entry#F1LZ40-1", "sequence": { "sequence": "MKCFFPVLSCLAVLVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETLQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREAKGQLKVAKEGDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLKSSMSVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTVQPGSSYWERSSYGGIQMEQVQPNSFSLGIFSSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRPIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQAQGSLSILETRQIQLECVVLNRTSMASQLVVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHVESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLLSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKATFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEVSEEEASEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKGWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1064, "header": "tr|F1LZ40-1|A0A0G2K7L2_RAT Computationally mapped isoform of Immunoglobulin superfamily, member 3 OS=Rattus norvegicus OX=10116 GN=Igsf3 PE=4 SV=2 CANONICAL=A0A0G2K7L2-1" }, "locus": { "chromosome": "2", "start_pos": 188896272, "end_pos": 188812796, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000018895.7", "url": "https://www.ensembl.org/id/ENSRNOT00000018895.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000018894.6", "url": "https://www.ensembl.org/id/ENSRNOP00000018894.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:295325", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:295325", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XZV7-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "IGSF3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPPRPPLTSLLLLIFVLLLGMAFAQRHVAVQEGPLYRTEGSHVTLWCKVSGYQGPAEQTFQWSIYLPSASEREVQIVSTADPSFPYAIYTQRVRAQEIYVERVQGDAVLLHITELQDRDAGEYECHTPNTDERYFGSYSAKTNLTVIPDSLRVTAVPQTLHRVERDSLELKCEVSKSTAQHSHVSISWYRQRGGEAPVEIISLSRDFVLRAGGTYAQRHATGDVRLDKVGETTSKLTIYNLHPSDQGEFYCEAAEWIQDPDKSWYAMTRKRSQGTIVNVQATDKEFSVRLETEKRMYIVGEPVEFRCILEAQNIPDRYFSISWAFNSSLIASLGPNAVPVLNNEFAQREALGQLKVAKESDNVFVLKIYRLRLEDSGKYNCRVTEREKTVTGDFIDKESKRPKNIPITVLPLKTSISLEIVNNASSVLEGESLRFGCNVRSNVGPQSRLSIAWQLVDKQNRRSEIVRLDRDGTLQPGPLYAERSSYGGIQMEQVRPGSFTLEIFNSVRADEGHYECRVAEWMRTLDGEWQIAGERHAGTPVTITALEAGFAVTAISRTPGVTYNESFDLQCIIKPHYPSWVPVSVTWRFQPAGSSEFHDLVTFTRDGGVQWGDRYLGFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNSSWTRLADRTSNLLEIRVLRPVTKLQVSKSKRSITLVENRPIPLNCSVKSQTSPDSHFAVLWYVHKPSDADGKLILKTTHSSAFEYGTYAEEEGLRGRLQFERSASGGLFSLTVQRAEVRDSGSYYCHVEEWLLSPNHAWYKLAEEVSGRTEVTVKQPDNRLHVNQTHRNITVLENQWVTLECQVSSRTSPSSQLQVEWYVWRPGHPEKEAVARLSRQSTLRYGDLATLGNLRSRLHLESPSPGLYLLSIQNATVRDSGTYDCRVEEWLLDPSDRWYKRAEDLSGLTTLTVKQPEPTLQVDTATANLTVQEKESFQLDCSILSRSSPKSHFAVTWYNLRAKEAGGHAEEEEKEEEEEKEVVLSVGLDTIFNSGTGRWQDRLCFQRLSAVLFRLTVLQASGADTGNYSCRVEEWLADPSGMWYRLAEEESGTVAVHVQDAGSTLQSVICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGTID", "length": 1183 }, "evidence": [ { "id": "A0A0G2K7L2", "url": "https://omabrowser.org/oma/group/A0A0G2K7L2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AAA9SQY2-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "IGSF3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVSIQEGPLYRTEGSHITIWCNVSGFQGPSEQNFQWSVYMPKAPEREIQIISTMDDTFSYAIYTQRVRSGQIYVERVQGNLALLHIIDLQTRDAGVYECHTPSTDERYFGSYSAKTTVVVIPDTLQATAVPQTLHKVEQDRLELTCDTSTETLQHSHLSVAWLRQRGGEKPVEVIALSRNFVLQSSSDYVQRQSLGEVRLDKLGSTTFRLTIFHLQPFDQGEFYCEATEWIQDPDGSWYPMTRKRSEGTVVNVQPTDKEFTVRLETEKRLYTVGEPMEFRCILEAQNIPDRYFAVSWAFNSSLIASMGPNAVPVLNSEFTHREARGELQVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPVIVLPITDNWVVKVPQHHQILPQGHLESSIFVDVASNASVILEGDNLHLTCSIRTTGRPLSRFSVIWQLVDRQNRRSNIVWLDRDGTVQPGASYWERNSFGGIQMEQVQPNSFSLSIFNTRKEDEGQYECHVTEWVRAVDNEWQIAGERRASTLVSITALETGFAVTAISRTPGVTYNDSFDLQCIIKPHYLSRVPVSVTWRFQPVGTIEFHGLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNSWMRLAERTSNLLEIRVLQPVTNLQVSKSKRTLTLVENRPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHMSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKRPDSRLKLSQEQGNLSVLETRQVQLECVVLNRTSAASQLLVEWFVWKPNQPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCRVEEWLPSPSGMWYKQAEDTAGQMAVRVTRPDAALQVDTVVPNATVFEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRGSPGPEDGEEEEEEEVEVDEEEDEDPTERTALLSVGADAVFGPEGSPWEGRLRFQMLSPLLYRLTVLQASPQDTGNYSCRVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSSTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1214 }, "evidence": [ { "id": "A0A0G2K7L2", "url": "https://omabrowser.org/oma/group/A0A0G2K7L2/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O75054-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "IGSF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTMDSSFPYAIYTQRVRGGKIFIERVQGNSTLLHITDLQARDAGEYECHTPSTDKQYFGSYSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLELTCEVASETIQHSHLSVAWLRQKVGEKPVEVISLSRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPVEFRCILEAQNVPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREARGQLKVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIIVLPLKSSISVEVASNASVILEGEDLRFSCSVRTAGRPQGRFSVIWQLVDRQNRRSNIMWLDRDGTVQPGSSYWERSSFGGVQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTPISITALEMGFAVTAISRTPGVTYSDSFDLQCIIKPHYPAWVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENKPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLRLSQAQGNLSVLETRQVQLECVVLNRTSITSQLMVEWFVWKPNHPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHVEEWLPSPSGMWYKRAEDTAGQTALTVMRPDASLQVDTVVPNATVSEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRSSPGLEEQEEEREEEEEEDDDDDDDPTERTALLSVGPDAVFGPEGSPWEGRLRFQRLSPVLYRLTVLQASPQDTGNYSCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSPTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSDGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1194 }, "evidence": [ { "id": "47567694", "url": "http://www.informatics.jax.org/homology/47567694", "database": "MGI" }, { "id": "A0A0G2K7L2", "url": "https://omabrowser.org/oma/group/A0A0G2K7L2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6ZQA6-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "Igsf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTESSHITIWCNVSGYQGPSEQNFQWSIYLPSAPEREVQIVSTVDSSFPYAIYTQRVRGGKIYVERIQGNSALLHITDLQARDAGEYECHTPNTDERYFGSYSAKMNLVVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETVQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSDFAHREAKGQLKVAKESDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLKSSISVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTLQPGSAYWERSSYGGIQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRAIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHSSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQVQGSLSVLETRQIQLECVVLNRTSVASQLLVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHAESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLPSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKAAFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEEEEDISQEEDSEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1194 }, "evidence": [ { "id": "47567694", "url": "http://www.informatics.jax.org/homology/47567694", "database": "MGI" }, { "id": "A0A0G2K7L2", "url": "https://omabrowser.org/oma/group/A0A0G2K7L2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lacrimal gland development", "id": "GO:0032808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032808", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1073, "end_pos": 1075, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1149, "end_pos": 1151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1171, "end_pos": 1173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 700, "end_pos": 702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" }, { "start_pos": 961, "end_pos": 963, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K7L2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1190, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K7L2-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1073, "end_pos": 1075 }, { "start_pos": 1149, "end_pos": 1151 }, { "start_pos": 1171, "end_pos": 1173 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 700, "end_pos": 702 }, { "start_pos": 842, "end_pos": 844 }, { "start_pos": 961, "end_pos": 963 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }