{ "uniprot_canonical_ac": "A0A0G2K2P4-1", "uniprot_ac": "A0A0G2K2P4", "uniprot_id": "A0A0G2K2P4_RAT", "mass": { "chemical_mass": 56224.0, "monoisotopic_mass": 56224.0 }, "refseq": {}, "gene_names": [ { "name": "Cyp2t1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4", "id": "A0A0G2K2P4" } ], "protein_names": [ { "name": "Cytochrome P450, family 2, subfamily t, polypeptide 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P4/entry#names_and_taxonomy", "id": "A0A0G2K2P4" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Cyp2t1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4", "locus": { "chromosome": "1", "start_pos": 82451563, "end_pos": 82446921, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000028891", "url": "https://www.ensembl.org/id/ENSRNOG00000028891" } ] } } ], "crossref": [ { "id": "A0A0G2K2P4", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K2P4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000028891", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000028891", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FHDNFRI", "url": "https://omabrowser.org/oma/group/FHDNFRI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K2P4", "url": "https://www.orthodb.org/?gene=A0A0G2K2P4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF84", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF84", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "620086", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620086", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K2P4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PSZ7", "url": "https://www.uniprot.org/uniprot/E9PSZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PSZ7-1", "url": "https://www.uniprot.org/uniprot/E9PSZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVTCEATLLLLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGNLLQLQSGHLDRVLMELSSRWGPVFTVWLGPRPAVVLSGYAALRDALVLQADAFSGRGSMAVFERFTHGNGIVFSNGPRWRTLRNFALGALKEFGVGTSTIEERILEETACVLDEFQATMGAPFDPRRLLDNAVSNVICTVVFGKRYNYGDPEFLRLLDLFSDNFRIMSSRWGETYNMFPSFMDWIPGPHHRIFKNFQELRLFISEQIQWHRQSRQTGEPRDFIDCFLEQMDKEHQDPESHFQDETLVMTTHNLFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTRAPSLADRAHLPYTNAVLHEIQRFISVLPLGLPRALIRDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEFQNNDAFMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPADIDLTPQCTGLGNVPPAFQLRLVAR", "length": 497, "header": "tr|A0A0G2K2P4-1|A0A0G2K2P4_RAT Isoform 1 of Cytochrome P450, family 2, subfamily t, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2t1 PE=1 SV=1 CANONICAL=A0A0G2K2P4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2P4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P4/entry#A0A0G2K2P4-1", "sequence": { "sequence": "MVTCEATLLLLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGNLLQLQSGHLDRVLMELSSRWGPVFTVWLGPRPAVVLSGYAALRDALVLQADAFSGRGSMAVFERFTHGNGIVFSNGPRWRTLRNFALGALKEFGVGTSTIEERILEETACVLDEFQATMGAPFDPRRLLDNAVSNVICTVVFGKRYNYGDPEFLRLLDLFSDNFRIMSSRWGETYNMFPSFMDWIPGPHHRIFKNFQELRLFISEQIQWHRQSRQTGEPRDFIDCFLEQMDKEHQDPESHFQDETLVMTTHNLFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTRAPSLADRAHLPYTNAVLHEIQRFISVLPLGLPRALIRDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEFQNNDAFMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPADIDLTPQCTGLGNVPPAFQLRLVAR", "length": 497, "header": "tr|A0A0G2K2P4-1|A0A0G2K2P4_RAT Isoform 1 of Cytochrome P450, family 2, subfamily t, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2t1 PE=1 SV=1 CANONICAL=A0A0G2K2P4-1" }, "locus": { "chromosome": "1", "start_pos": 82451456, "end_pos": 82447904, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079995.2", "url": "https://www.ensembl.org/id/ENSRNOT00000079995.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072323.1", "url": "https://www.ensembl.org/id/ENSRNOP00000072323.1" } ] } }, { "isoform_ac": "E9PSZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2P4/entry#E9PSZ7-1", "sequence": { "sequence": "VEGARHDRMVTCEATLLLLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGNLLQLQSGHLDRVLMELSSRWGPVFTVWLGPRPAVVLSGYAALRDALVLQADAFSGRGSMAVFERFTHGNGIVFSNGPRWRTLRNFALGALKEFGVGTSTIEERILEETACVLDEFQATMGAPFDPRRLLDNAVSNVICTVVFGKRYNYGDPEFLRLLDLFSDNFRIMSSRWGETYNMFPSFMDWIPGPHHRIFKNFQELRLFISEQIQWHRQSRQTGEPRDFIDCFLEQMDKEHQDPESHFQDETLVMTTHNLFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTRAPSLADRAHLPYTNAVLHEIQRFISVLPLGLPRALIRDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEFQNNDAFMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPADIDLTPQCTGLGNVPPAFQLRLVAR", "length": 505, "header": "tr|E9PSZ7-1|E9PSZ7_RAT Computationally mapped isoform of Cytochrome P450, family 2, subfamily t, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2t1 PE=1 SV=2 CANONICAL=A0A0G2K2P4-1" }, "locus": { "chromosome": "1", "start_pos": 82451456, "end_pos": 82446921, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000068322.2", "url": "https://www.ensembl.org/id/ENSRNOT00000068322.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000061482.2", "url": "https://www.ensembl.org/id/ENSRNOP00000061482.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3Z7F6-1", "protein_name": "Cytochrome P450, family 2, subfamily t, polypeptide 4", "gene_name": "Cyp2t4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVTCLALLLLLLILMLLLWWGGVVRRQAQMQKDLPPGPAPLPLLGNLLQLQSGDLDRVLMELSSHWGPVFTVWLGPLPAVVLCGYEALRDALVLQADAFSGRGAMAVFDRFTCGNGIVFSNGPRWHSLRNFALGVLRELGVGRSTIEDRILEEAACVLDEFQATMGAPFDPQQLLDSAVSNVICTVVFGKRYDYGDPEFRRLLNLFSDNFCIMSSRWAEIYNMFPSFMDWIPGPHNRIFKNFQELRLFISEQIQWHWQSRQTGEPRDFIDCFLDQMDKEQQDLESHFQDETLVMTTHDLFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTWAPRIEDRARLPYTNAVLHEIQRFISVLPLGLPRALTRDVNLKNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDHGEFQNNDAFMPFALGKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPANINLNPQCTGLGNVPPAFQLRLVAR", "length": 495 }, "evidence": [ { "id": "A0A0G2K2P4", "url": "https://omabrowser.org/oma/group/A0A0G2K2P4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54KV0-1", "protein_name": "Probable cytochrome P450 513B1", "gene_name": "cyp513B1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLLVLSVILAIIIYLIFKRNYKYSPSKINSKIPGPIGLPIFGNILSLDNKNGIHTTFQKWFKIYGPIYSVNMGNKSAVVLTGFPIIKKAFIDNSEAFAPHYTFESRYKLNKCSDITQENGKNQSALKRIFLSELTVTRIKKQESHIQNEIVKLMKVLDKHSEDGKPFLLNNYFSMFSINIISRFLFGIDFPYQDFEETSDLMVGIRDLLIASGEIVLSDFLPIPHSKRSKLYTSYQALVVQIETLVKSHKYKEDDECMLSKLMIEHDKGNIPWDAVISNCNTIITAGSDSTSSTALFFLIEMMNNPTIQTKVYNDIVVSFEQNQQADDYMNESMVILKYSKYRSLIPYLSLALKENYRKHPAAPFGAPHETTQETVIEGYTIAKGTMIFQNIYATQRSDTFYSQPDEFIPERWNGDENSQTLISFGTGIRDCIGKSLAYNEIFTIIASVLNRYEFINPNPSIPFDDNGIPGLTTQCKNTVVQIKKR", "length": 487 }, "evidence": [ { "id": "A0A0G2K2P4", "url": "https://omabrowser.org/oma/group/A0A0G2K2P4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "arachidonic acid epoxygenase activity", "id": "GO:0008392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" }, { "name": "epoxygenase P450 pathway", "id": "GO:0019373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2P4", "url": "https://www.uniprot.org/uniprot/A0A0G2K2P4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K2P4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 497, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K2P4-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }