{
    "uniprot_canonical_ac": "A0A0G2JWD3-1",
    "uniprot_ac": "A0A0G2JWD3",
    "uniprot_id": "A0A0G2JWD3_RAT",
    "mass": {
        "chemical_mass": 32733.0,
        "monoisotopic_mass": 32733.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Asb8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3",
            "id": "A0A0G2JWD3"
        }
    ],
    "protein_names": [
        {
            "name": "Ankyrin repeat and SOCS box protein 8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWD3/entry#names_and_taxonomy",
            "id": "A0A0G2JWD3"
        }
    ],
    "function": [
        {
            "annotation": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B5DF17",
                    "url": "https://www.uniprot.org/uniprot/B5DF17#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00003062",
                    "url": "https://www.uniprot.org/uniprot/ARBA00003062#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JWD3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JWD3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3"
                }
            ],
            "common_name": "Rat",
            "glygen_name": "Rat",
            "reference_species": "Rattus norvegicus [10116]"
        }
    ],
    "gene": [
        {
            "name": "Asb8",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3",
            "locus": {
                "chromosome": "7",
                "start_pos": 129261397,
                "end_pos": 129297485,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000010099",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000010099"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000010099",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010099",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd03727",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03727",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "315287",
            "url": "https://www.ncbi.nlm.nih.gov/gene/315287",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001496",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036036",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036770",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037332",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037332",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:315287",
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:315287",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "LHCACMA",
            "url": "https://omabrowser.org/oma/group/LHCACMA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "B5DF17",
            "url": "https://www.orthodb.org/?gene=B5DF17",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24134",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24134",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24134:SF30",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24134:SF30",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24134:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24134:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07525",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12796",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13637",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8951664",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1309246",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309246",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2JWD3",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JWD3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B5DF17",
            "url": "https://www.uniprot.org/uniprot/B5DF17",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B5DF17-1",
            "url": "https://www.uniprot.org/uniprot/B5DF17-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPHTDSTRGLGQEGGEVPGEAPKIMGSRCIGPGVWPIQSSTSLTQTKDTWKGRTSMKGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE",
        "length": 302,
        "header": "tr|A0A0G2JWD3-1|A0A0G2JWD3_RAT Isoform 1 of Ankyrin repeat and SOCS box protein 8  OS=Rattus norvegicus OX=10116 GN=Asb8 PE=3 SV=1 CANONICAL=A0A0G2JWD3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JWD3-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWD3/entry#A0A0G2JWD3-1",
            "sequence": {
                "sequence": "MPHTDSTRGLGQEGGEVPGEAPKIMGSRCIGPGVWPIQSSTSLTQTKDTWKGRTSMKGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE",
                "length": 302,
                "header": "tr|A0A0G2JWD3-1|A0A0G2JWD3_RAT Isoform 1 of Ankyrin repeat and SOCS box protein 8  OS=Rattus norvegicus OX=10116 GN=Asb8 PE=3 SV=1 CANONICAL=A0A0G2JWD3-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 129297484,
                "end_pos": 129262532,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000079377.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000079377.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069835.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069835.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "B5DF17-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWD3/entry#B5DF17-1",
            "sequence": {
                "sequence": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE",
                "length": 288,
                "header": "tr|B5DF17-1|A0A0G2JWD3_RAT Computationally mapped isoform of Ankyrin repeat and SOCS box protein 8  OS=Rattus norvegicus OX=10116 GN=Asb8 PE=3 SV=1 CANONICAL=A0A0G2JWD3-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 129268921,
                "end_pos": 129262532,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000013704.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000013704.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000013704.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000013704.4"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:315287",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:315287",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-8951664",
            "name": "Neddylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664",
            "resource": "Reactome",
            "description": "Neddylation"
        },
        {
            "id": "R-RNO-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q08E43-1",
            "protein_name": "Ankyrin repeat and SOCS box protein 8",
            "gene_name": "ASB8",
            "tax_id": 9913,
            "organism": "Bos taurus",
            "sequence": {
                "sequence": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVAKDQQLCEKLTVLCSAPGTLKTLSRYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLIE",
                "length": 288
            },
            "evidence": [
                {
                    "id": "A0A0G2JWD3",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JWD3/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Bovine",
            "common_name": "Bovine"
        },
        {
            "uniprot_canonical_ac": "Q91ZT9-1",
            "protein_name": "Ankyrin repeat and SOCS box protein 8",
            "gene_name": "Asb8",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAERDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPVSLKDYLLLLE",
                "length": 288
            },
            "evidence": [
                {
                    "id": "47558302",
                    "url": "http://www.informatics.jax.org/homology/47558302",
                    "database": "MGI"
                },
                {
                    "id": "A0A0G2JWD3",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JWD3/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9H765-1",
            "protein_name": "Ankyrin repeat and SOCS box protein 8",
            "gene_name": "ASB8",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE",
                "length": 288
            },
            "evidence": [
                {
                    "id": "47558302",
                    "url": "http://www.informatics.jax.org/homology/47558302",
                    "database": "MGI"
                },
                {
                    "id": "A0A0G2JWD3",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JWD3/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "intracellular signal transduction",
                        "id": "GO:0035556",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWD3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWD3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWD3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
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        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 100,
            "end_pos": 102,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 165,
            "end_pos": 167,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 62,
            "end_pos": 64,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "structures": [],
    "synthesized_glycans": [],
    "enzyme_annotation": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 100,
                "end_pos": 102
            },
            {
                "start_pos": 165,
                "end_pos": 167
            },
            {
                "start_pos": 62,
                "end_pos": 64
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        ]
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                    "field": "total_sites",
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                    "field": "o_linked_glycans",
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