{ "uniprot_canonical_ac": "A0A0G2JTZ2-1", "uniprot_ac": "A0A0G2JTZ2", "uniprot_id": "SOX6_RAT", "mass": { "chemical_mass": 91816.0, "monoisotopic_mass": 91816.0 }, "refseq": { "ac": "NP_001019922", "name": "transcription factor SOX-6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" }, "gene_names": [ { "name": "Sox6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2" }, { "name": "Sox-6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2" }, { "name": "Sox6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922", "id": "NP_001019922" } ], "protein_names": [ { "name": "Transcription factor SOX-6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTZ2/entry#names_and_taxonomy", "id": "A0A0G2JTZ2" }, { "name": "SRY-box containing gene 6; SRY (sex determining region Y)-box 6; SRY box 6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922", "id": "NP_001019922" }, { "name": "transcription factor SOX-6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922", "id": "NP_001019922" } ], "function": [ { "annotation": "LncRNA Gm4419 induces cell apoptosis in hepatic ischemia-reperfusion injury via regulating the miR-455-SOX6 axis.", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" }, { "database": "PubMed", "id": "32114773", "url": "https://glygen.org/publication/PubMed/32114773" } ] }, { "annotation": "Sox6 was specifically expressed in the neonatal brain and adult testis with Northern blotting.", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" }, { "database": "PubMed", "id": "12081133", "url": "https://glygen.org/publication/PubMed/12081133" } ] }, { "annotation": "The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499 in rat cardiomyocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" }, { "database": "PubMed", "id": "26659076", "url": "https://glygen.org/publication/PubMed/26659076" } ] }, { "annotation": "The authors proved that miR-499-5p inhibited hypoxia/reoxygenation-induced cardiomyocytes injury by targeting SOX6.", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" }, { "database": "PubMed", "id": "31076992", "url": "https://glygen.org/publication/PubMed/31076992" } ] }, { "annotation": "Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (By similarity). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (By similarity). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (By similarity). Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#function" }, { "database": "PubMed", "id": "26150426", "url": "https://glygen.org/publication/PubMed/26150426" }, { "database": "UniProtKB", "id": "P40645", "url": "https://www.uniprot.org/uniprot/P40645#function" } ] } ], "disease": [ { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:114", "recommended_name": { "id": "DOID:114", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:114", "name": "heart disease", "description": "A cardiovascular system disease that involves the heart." }, "synonyms": [], "evidence": [ { "id": "114", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:114" } ] }, { "disease_id": "DOID:3070", "recommended_name": { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine." }, "synonyms": [ { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "Neuroglial tumor", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "glial cell tumor", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "glioma, malignant", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "malignant Neuroglial tumor", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "malignant glioma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma susceptibility 1", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "GLM1", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioblastoma, somatic", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma susceptibility 1", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma susceptibility 1, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma, susceptibility to, somatic", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "astrocytoma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "ependymoma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioblastoma multiforme", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma of brain, familial", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "oligodendroglioma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "subependymoma", "description": "" }, { "id": "MIM:137800", "resource": "MIM", "url": "https://www.omim.org/entry/137800", "name": "Glioma 1", "description": "Glioma 1" } ], "evidence": [ { "id": "3070", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Sox6", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "locus": { "chromosome": "1", "start_pos": 169729194, "end_pos": 170277386, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020514", "url": "https://www.ensembl.org/id/ENSRNOG00000020514" } ] } } ], "crossref": [ { "id": "A0A0G2JTZ2", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JTZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000020514", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020514", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "293165", "url": "https://www.ncbi.nlm.nih.gov/gene/293165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:293165", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:293165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDKAMNG", "url": "https://omabrowser.org/oma/group/GDKAMNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JTZ2", "url": "https://www.orthodb.org/?gene=A0A0G2JTZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A6I8PLH1", "url": "https://www.orthodb.org/?gene=A0A6I8PLH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A6R0V8A0", "url": "https://www.orthodb.org/?gene=A0A6R0V8A0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45789", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45789", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45789:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45789:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0G2JTZ2", "url": "http://purl.obolibrary.org/obo/PR_A0A0G2JTZ2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-3769402", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3769402", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1309000", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309000", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JTZ2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JTZ2-2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6I8PLH1", "url": "https://www.uniprot.org/uniprot/A0A6I8PLH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6I8PLH1-1", "url": "https://www.uniprot.org/uniprot/A0A6I8PLH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6R0V8A0", "url": "https://www.uniprot.org/uniprot/A0A6R0V8A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6R0V8A0-1", "url": "https://www.uniprot.org/uniprot/A0A6R0V8A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZNG0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZNG0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 827, "header": "sp|A0A0G2JTZ2-1|SOX6_RAT Isoform 1 of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JTZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTZ2/entry#A0A0G2JTZ2-1", "sequence": { "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 827, "header": "sp|A0A0G2JTZ2-1|SOX6_RAT Isoform 1 of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1" }, "locus": {} }, { "isoform_ac": "A0A0G2JTZ2-2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTZ2/entry#A0A0G2JTZ2-2", "sequence": { "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 786, "header": "sp|A0A0G2JTZ2-2|SOX6_RAT Isoform 2 of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1" }, "locus": {} }, { "isoform_ac": "A0A6I8PLH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTZ2/entry#A0A6I8PLH1-1", "sequence": { "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 828, "header": "tr|A0A6I8PLH1-1|SOX6_RAT Computationally mapped isoform of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1" }, "locus": { "chromosome": "1", "start_pos": 170034378, "end_pos": 169729395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000048020.5", "url": "https://www.ensembl.org/id/ENSRNOT00000048020.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000044088.4", "url": "https://www.ensembl.org/id/ENSRNOP00000044088.4" } ] } }, { "isoform_ac": "A0A6R0V8A0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTZ2/entry#A0A6R0V8A0-1", "sequence": { "sequence": "MPSSSEVLADVARESRIEEWRNSYFVRMSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 813, "header": "tr|A0A6R0V8A0-1|SOX6_RAT Computationally mapped isoform of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1" }, "locus": { "chromosome": "1", "start_pos": 170049962, "end_pos": 169729395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079072.2", "url": "https://www.ensembl.org/id/ENSRNOT00000079072.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068898.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068898.2" } ] } }, { "isoform_ac": "A0A8I5ZNG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTZ2/entry#A0A8I5ZNG0-1", "sequence": { "sequence": "MKERGRERLADVMRRGEGVRRRALPRLLPSALTAALGNSQANTNSFSPAACPLSLRMSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 842, "header": "tr|A0A8I5ZNG0-1|A0A8I5ZNG0_RAT Computationally mapped isoform of SRY-box transcription factor 6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=4 SV=1 CANONICAL=A0A0G2JTZ2-1" }, "locus": { "chromosome": "1", "start_pos": 170277367, "end_pos": 169729395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094350.1", "url": "https://www.ensembl.org/id/ENSRNOT00000094350.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079879.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079879.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 119, "end_pos": 119, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "site_lbl": "Thr119" }, { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A0A0G2JTZ2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2JTZ2" } ], "site_lbl": "Ser126" }, { "start_pos": 399, "end_pos": 399, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "site_lbl": "Ser399" }, { "start_pos": 401, "end_pos": 401, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "site_lbl": "Thr401" }, { "start_pos": 439, "end_pos": 439, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "site_lbl": "Ser439" }, { "start_pos": 442, "end_pos": 442, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "site_lbl": "Ser442" }, { "start_pos": 471, "end_pos": 471, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A0A0G2JTZ2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A0G2JTZ2" } ], "site_lbl": "Ser471" } ], "glycation": [], "keywords": [], "publication": [ { "title": "cDNA cloning of the Sry-related gene Sox6 from rat with tissue-specific expression.", "journal": "Biological & pharmaceutical bulletin", "date": "2002", "authors": "Narahara M, Yamada A, Hamada-Kanazawa M, Kawai Y, Miyake M", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" } ], "reference": [ { "type": "PubMed", "id": "12081133", "url": "https://glygen.org/publication/PubMed/12081133" } ] }, { "title": "The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.", "journal": "Nucleic acids research", "date": "2015-09-30", "authors": "Liu Chia-Feng, Lefebvre V\u00e9ronique", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "reference": [ { "type": "PubMed", "id": "26150426", "url": "https://glygen.org/publication/PubMed/26150426" } ] }, { "title": "SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2016", "authors": "Jia Z, Wang J, Shi Q, Liu S, Wang W, Tian Y, Lu Q, Chen P, Ma K, Zhou C", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" } ], "reference": [ { "type": "PubMed", "id": "26659076", "url": "https://glygen.org/publication/PubMed/26659076" } ] }, { "title": "MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6.", "journal": "Biotechnology letters", "date": "2019", "authors": "Shi Y, Han Y, Niu L, Li J, Chen Y", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" } ], "reference": [ { "type": "PubMed", "id": "31076992", "url": "https://glygen.org/publication/PubMed/31076992" } ] }, { "title": "LncRNA Gm4419 induces cell apoptosis in hepatic ischemia-reperfusion injury via regulating the miR-455-SOX6 axis.", "journal": "Biochemistry and cell biology = Biochimie et biologie cellulaire", "date": "2020", "authors": "Ying D, Zhou X, Ruan Y, Wang L, Wu X", "evidence": [ { "database": "RefSeq", "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922" } ], "reference": [ { "type": "PubMed", "id": "32114773", "url": "https://glygen.org/publication/PubMed/32114773" } ] } ], "pathway": [ { "id": "rno:293165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:293165", "resource": "KEGG Pathway" }, { "id": "R-RNO-3769402", "name": "Deactivation of the beta-catenin transactivating complex", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3769402", "resource": "Reactome", "description": "Deactivation of the beta-catenin transactivating complex" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BE01-1", "protein_name": "SRY-box transcription factor 6", "gene_name": "SOX6", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVNTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGLSDRLGRSLDTFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNAAGAVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTVEPVKSPTSPTQSLFSASKTSPVNLPNKSSIPSPIGGSLGRGSSLGKWKSQHQEETYELDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSTLNNMGLNNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSSYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN", "length": 843 }, "evidence": [ { "id": "A0A0G2JTZ2", "url": "https://omabrowser.org/oma/group/A0A0G2JTZ2/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1NAU5-1", "protein_name": "SRY-box 6", "gene_name": "SOX6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSNSEVLAGVVGESRTEEWMNSHYIRMSSKQATSPFACAADGEETMTQDLASRDKEEGNSDQHATSHLPLHNVMHNKPHSEELPTLVTTIQQDAEWDGVISAQHRMESESNKLCSLYSFRNTSTSPHKPDEGSRDRSELMTSVNFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMEKLNTSDLLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNTAGALSPTGMKNEKRGTSPVTQVKDEAAQPLNLSARPKTAEPVKSPTSPTQNLFPPSKSSPVTVTNKSGIPSPLGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQQPHGVDGKLPSMNNMGLNNCRNEKERTRFENLGPQLTGKPNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDSRGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSIPVIQSTYGMKTDSGSLAGNEMINGEDEIEMYEDYEDDPKSDYSSENEAHEAVSAN", "length": 817 }, "evidence": [ { "id": "A0A0G2JTZ2", "url": "https://omabrowser.org/oma/group/A0A0G2JTZ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P35712-1", "protein_name": "Transcription factor SOX-6", "gene_name": "SOX6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINQRLKGLSDRFGRNLDTFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN", "length": 828 }, "evidence": [ { "id": "47571675", "url": "http://www.informatics.jax.org/homology/47571675", "database": "MGI" }, { "id": "A0A0G2JTZ2", "url": "https://omabrowser.org/oma/group/A0A0G2JTZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P40645-1", "protein_name": "Transcription factor SOX-6", "gene_name": "Sox6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN", "length": 827 }, "evidence": [ { "id": "47571675", "url": "http://www.informatics.jax.org/homology/47571675", "database": "MGI" }, { "id": "A0A0G2JTZ2", "url": "https://omabrowser.org/oma/group/A0A0G2JTZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity", "id": "GO:0001217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001217", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": 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