{

	"biomarker_id": {
		"biomarker_id": "A0491",
		"biomarker_url": "https://data.glygen.org/GLY_000737"
	},
	"biomarker": "increased level",
	"assessed_biomarker_entity": {
        "name": "Biantennary bisected core fucosylated N-glycan (A2G1(6)FB)",
        "url": "https://data.glygen.org/GLY_000737"
    },
    "assessed_entity_type": "glycan",
	"best_biomarker_type": {
		"id": "diagnostic",
		"url": "https://www.ncbi.nlm.nih.gov/books/NBK326791/"
	},
	"loinc_code": "NA",
	"tissue": {
		"name": "blood",
		"namespace": "UBERON",
		"id": "0000178",
		"url": "http://purl.obolibrary.org/obo/UBERON_0000178"
	},
	"disease": {
		"disease_id": "DOID:3571",
		"recommended_name": {
			"id": "DOID:3571",
			"resource": "Disease Ontology",
			"url": "http://disease-ontology.org/term/DOID:3571",
			"name": "liver cancer",
			"description": "A hepatobiliary system cancer that is located_in the liver."
		},
		"synonyms": [{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "Ca liver - primary",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "Resectable malignant neoplasm of Liver",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "hepatic cancer",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "hepatic neoplasm",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "malignant hepato-biliary neoplasm",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "malignant neoplasm of liver",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "malignant neoplasm of liver, primary",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "malignant tumor of liver",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "neoplasm of liver",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "non-resectable primary hepatic malignant neoplasm",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "primary liver cancer",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "primary malignant neoplasm of liver",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "resectable malignant neoplasm of the liver",
				"description": ""
			},
			{
				"id": "DOID:3571",
				"resource": "Disease Ontology",
				"url": "http://disease-ontology.org/term/DOID:3571",
				"name": "malignant neoplasm of liver, not specified as primary or secondary",
				"description": ""
			}
		]
	},
    "literature_evidence": "The level of serum N-glycan A2G1(6)FB, a biantennary N-glycan containing core fucose and bisecting GlcNAc residues, was significantly higher in hepatitis C virus (HCV)-infected cirrhotic patients with HCC than in those without HCC. In addition, A2G1(6)FB was detectable in HCV-infected patients with early-stage HCC. In conclusion, the N-glycan A2G1(6)FB may be a potential biomarker to detect early HCC development in HCV-infected patients. [PMID:33255418]",
    "crossref": [],
    "publication": [{
		"title": "A Potential Serum N-glycan Biomarker for Hepatitis C Virus-Related Early-Stage Hepatocellular Carcinoma with Liver Cirrhosis.",
		"journal": "Int J Mol Sci",
		"date": "2020 Nov 24",
		"authors": "Higashi M, Yoshimura T, Usui N, Kano Y, Deguchi A, Tanabe K, Uchimura Y, Kuriyama S, Suzuki Y, Masaki T, Ikenaka K",
		"evidence": [{
			"database": "BiomarkerKB",
			"id": "A0491",
			"url": "https://data.glygen.org/GLY_000737"
		}]
    }],
	"biomarker_components": [{
		"glytoucan_ac": "G85767HW",
		"component_category": "glycan",
		"note": "Glycoprotein biomarker",
		"evidence": [
			{
				"id": "A0491",
				"database": "BiomarkerKB",
				"url": "https://data.glygen.org/GLY_000737"
			},
			{
				"id": "33255418",
				"database": "PubMed",
				"url": "https://glygen.org/publication/PubMed/33255418"
			}]
		},
		{
		"uniprot_canonical_ac": "P07911-1",
		"component_category": "protein",
		"note": "Glycoprotein biomarker",
		"evidence": [
			{
				"id": "A0491",
				"database": "BiomarkerKB",
				"url": "https://data.glygen.org/GLY_000737"
			},
			{
				"id": "33255418",
				"database": "PubMed",
				"url": "https://glygen.org/publication/PubMed/33255418"
			}]
		}
	
	]

}