{ "uniprot_canonical_ac": "P14373-1", "uniprot_ac": "P14373", "uniprot_id": "TRI27_HUMAN", "mass": { "chemical_mass": 58490.0, "monoisotopic_mass": 58490.0 }, "refseq": { "ac": "NP_006501", "name": "zinc finger protein RFP", "summary": "This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" }, "gene_names": [ { "name": "TRIM27", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P14373", "id": "P14373" }, { "name": "RFP; RNF76", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501", "id": "NP_006501" }, { "name": "RFP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P14373", "id": "P14373" }, { "name": "RNF76", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P14373", "id": "P14373" }, { "name": "TRIM27", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501", "id": "NP_006501" } ], "protein_names": [ { "name": "Zinc finger protein RFP", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P14373" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14373" }, { "name": "RING finger protein 76", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14373" }, { "name": "Ret finger protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14373" }, { "name": "Tripartite motif-containing protein 27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14373" }, { "name": "ret finger protein; tripartite motif protein TRIM27; RFP transforming protein; RING finger protein 76; tripartite motif-containing protein 27; RING-type E3 ubiquitin transferase TRIM27", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501", "id": "NP_006501" }, { "name": "zinc finger protein RFP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501", "id": "NP_006501" } ], "function": [ { "annotation": "(Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection.", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373#function" }, { "database": "PubMed", "id": "29688809", "url": "https://glygen.org/publication/PubMed/29688809" } ] }, { "annotation": "Analysis of TRIM27 prognosis value and immune infiltrates in hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" }, { "database": "PubMed", "id": "36217828", "url": "https://glygen.org/publication/PubMed/36217828" } ] }, { "annotation": "CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" }, { "database": "PubMed", "id": "36538041", "url": "https://glygen.org/publication/PubMed/36538041" } ] }, { "annotation": "E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (PubMed:26358190, PubMed:29688809). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (PubMed:22829933). Alternatively, facilitates mitophagy via stabilization of active TBK1 (PubMed:36111389). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (PubMed:35670107). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (PubMed:35670107).", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373#function" }, { "database": "PubMed", "id": "23452853", "url": "https://glygen.org/publication/PubMed/23452853" }, { "database": "PubMed", "id": "22128329", "url": "https://glygen.org/publication/PubMed/22128329" }, { "database": "PubMed", "id": "36111389", "url": "https://glygen.org/publication/PubMed/36111389" }, { "database": "PubMed", "id": "26358190", "url": "https://glygen.org/publication/PubMed/26358190" }, { "database": "PubMed", "id": "10976108", "url": "https://glygen.org/publication/PubMed/10976108" }, { "database": "PubMed", "id": "12807881", "url": "https://glygen.org/publication/PubMed/12807881" }, { "database": "PubMed", "id": "29688809", "url": "https://glygen.org/publication/PubMed/29688809" }, { "database": "PubMed", "id": "35670107", "url": "https://glygen.org/publication/PubMed/35670107" }, { "database": "PubMed", "id": "24144979", "url": "https://glygen.org/publication/PubMed/24144979" }, { "database": "PubMed", "id": "22829933", "url": "https://glygen.org/publication/PubMed/22829933" } ] }, { "annotation": "TRIM27 expression is associated with poor prognosis in sinonasal mucosal melanoma.", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" }, { "database": "PubMed", "id": "36891983", "url": "https://glygen.org/publication/PubMed/36891983" } ] }, { "annotation": "This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 16, "end_pos": 16, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolished E3 ubiquitin-protein ligase activity; when associated with A-31.", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" }, { "database": "PubMed", "id": "22829933", "url": "https://glygen.org/publication/PubMed/22829933" } ] }, { "start_pos": 31, "end_pos": 31, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolished E3 ubiquitin-protein ligase activity; when associated with A-16.", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" }, { "database": "PubMed", "id": "22829933", "url": "https://glygen.org/publication/PubMed/22829933" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "87.3", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "78.02", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "90.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "83.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "91.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "93.14", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "86.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "90.24", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "83.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "92.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "94.55", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "92.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204713", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204713" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P14373", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P14373" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P14373", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P14373" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P14373", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P14373" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P14373", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P14373" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P14373", "url": 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"https://www.reactome.org/PathwayBrowser/#R-HSA-9635465", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0G2JIZ4", "url": "https://www.uniprot.org/uniprot/A0A0G2JIZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JIZ4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JIZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9B9", "url": "https://www.uniprot.org/uniprot/A0A140T9B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9B9-1", "url": "https://www.uniprot.org/uniprot/A0A140T9B9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9N6", "url": "https://www.uniprot.org/uniprot/A0A140T9N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9N6-1", "url": "https://www.uniprot.org/uniprot/A0A140T9N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Q6", "url": "https://www.uniprot.org/uniprot/A0A140T9Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Q6-1", "url": "https://www.uniprot.org/uniprot/A0A140T9Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9V9", "url": "https://www.uniprot.org/uniprot/A0A140T9V9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9V9-1", "url": "https://www.uniprot.org/uniprot/A0A140T9V9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y551", "url": "https://www.uniprot.org/uniprot/H0Y551", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y551-1", "url": "https://www.uniprot.org/uniprot/H0Y551-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P14373-1", "url": "https://www.uniprot.org/uniprot/P14373-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P14373-2", "url": "https://www.uniprot.org/uniprot/P14373-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "length": 513, "header": "sp|P14373-1|TRI27_HUMAN Isoform 1 of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JIZ4-1", "url": "", "sequence": { "sequence": "MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQ", "length": 249, "header": "tr|A0A0G2JIZ4-1|A0A0G2JIZ4_HUMAN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 189191, "end_pos": 185571, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000436621.1", "url": "https://www.ensembl.org/id/ENST00000436621.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000416983.1", "url": "https://www.ensembl.org/id/ENSP00000416983.1" } ] } }, { "isoform_ac": "A0A140T9B9-1", "url": "", "sequence": { "sequence": "XLREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "length": 207, "header": "tr|A0A140T9B9-1|A0A140T9B9_HUMAN Computationally mapped isoform of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 173017, "end_pos": 169827, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445968.5", "url": "https://www.ensembl.org/id/ENST00000445968.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000398968.1", "url": "https://www.ensembl.org/id/ENSP00000398968.1" } ] } }, { "isoform_ac": "A0A140T9N6-1", "url": "", "sequence": { "sequence": "XSADSLEGGILDLGSVLSHILPVSELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "length": 231, "header": "tr|A0A140T9N6-1|A0A140T9N6_HUMAN Computationally mapped isoform of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 173318, "end_pos": 169827, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000443804.1", "url": "https://www.ensembl.org/id/ENST00000443804.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000407693.1", "url": "https://www.ensembl.org/id/ENSP00000407693.1" } ] } }, { "isoform_ac": "A0A140T9Q6-1", "url": "", "sequence": { "sequence": "XLREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERSPSTT", "length": 52, "header": "tr|A0A140T9Q6-1|A0A140T9Q6_HUMAN Computationally mapped isoform of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 173017, "end_pos": 170012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440169.5", "url": "https://www.ensembl.org/id/ENST00000440169.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000410163.1", "url": "https://www.ensembl.org/id/ENSP00000410163.1" } ] } }, { "isoform_ac": "A0A140T9V9-1", "url": "", "sequence": { "sequence": "LKQFTEKMQSDMEKIQESADSLEGGILDLGSVLSHILPVSELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "length": 247, "header": "tr|A0A140T9V9-1|A0A140T9V9_HUMAN Computationally mapped isoform of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_SSTO_CTG1", "start_pos": 218386, "end_pos": 213475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437383.1", "url": "https://www.ensembl.org/id/ENST00000437383.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000414955.1", "url": "https://www.ensembl.org/id/ENSP00000414955.1" } ] } }, { "isoform_ac": "H0Y551-1", "url": "", "sequence": { "sequence": "XLKQFTEKMQSDMEKIQESADSLEGGILDLGSVLSHILPVSELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "length": 248, "header": "tr|H0Y551-1|H0Y551_HUMAN Computationally mapped isoform of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "6", "start_pos": 28908989, "end_pos": 28904071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414543.5", "url": "https://www.ensembl.org/id/ENST00000414543.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000400058.1", "url": "https://www.ensembl.org/id/ENSP00000400058.1" } ] } }, { "isoform_ac": "P14373-1", "url": "", "sequence": { "sequence": "MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "length": 513, "header": "sp|P14373-1|TRI27_HUMAN Isoform 1 of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_COX_CTG1", "start_pos": 414331, "end_pos": 394768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000435528.6", "url": "https://www.ensembl.org/id/ENST00000435528.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000405229.2", "url": "https://www.ensembl.org/id/ENSP00000405229.2" } ] } }, { "isoform_ac": "P14373-2", "url": "", "sequence": { "sequence": "MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERSPSTT", "length": 358, "header": "sp|P14373-2|TRI27_HUMAN Isoform 2 of Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1 CANONICAL=P14373-1" }, "locus": { "chromosome": "HSCHR6_MHC_COX_CTG1", "start_pos": 414331, "end_pos": 394953, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427689.6", "url": "https://www.ensembl.org/id/ENST00000427689.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000388622.2", "url": "https://www.ensembl.org/id/ENSP00000388622.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P14373", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P14373" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "22121020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22121020" } ] } ], "phosphorylation": [ { "start_pos": 341, "end_pos": 341, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P14373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P14373" }, { "database": "PubMed", "id": "19691289", "url": "https://glygen.org/publication/PubMed/19691289" } ], "site_lbl": "Ser341" }, { "start_pos": 483, "end_pos": 483, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P14373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P14373" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser483" }, { "start_pos": 493, "end_pos": 493, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P14373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P14373" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser493" }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P14373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P14373" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser499" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.", "journal": "J. Cell Sci.", "date": "1999", "authors": "Morris-Desbois C, Bochard V, Reynaud C, Jalinot P", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "10504338", "url": "https://glygen.org/publication/PubMed/10504338" } ] }, { "title": "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Shimono Y, Murakami H, Hasegawa Y, Takahashi M", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "10976108", "url": "https://glygen.org/publication/PubMed/10976108" } ] }, { "title": "The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Torres J, Pulido R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "11035045", "url": "https://glygen.org/publication/PubMed/11035045" } ] }, { "title": "The tripartite motif family identifies cell compartments.", "journal": "EMBO J.", "date": "2001", "authors": "Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci P G, Ballabio A", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "11331580", "url": "https://glygen.org/publication/PubMed/11331580" } ] }, { "title": "Direct identification of PTEN phosphorylation sites.", "journal": "FEBS letters", "date": "2002", "authors": "Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "12297295", "url": "https://glygen.org/publication/PubMed/12297295" } ] }, { "title": "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232142", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232142" } ], "reference": [ { "type": "PubMed", "id": "12393906", "url": "https://glygen.org/publication/PubMed/12393906" } ] }, { "title": "Differential expression of RET finger protein in testicular germ cell tumors.", "journal": "Pathol. Int.", "date": "2002", "authors": "Tezel Gaye, Nagasaka Tetsuro, Shimono Yohei, Takahashi Masahide", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "12445133", "url": "https://glygen.org/publication/PubMed/12445133" } ] }, { "title": "Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.", "journal": "Mutat. Res.", "date": "2003", "authors": "Saenko Vladimir, Rogounovitch Tatiana, Shimizu-Yoshida Yuki, Abrosimov Aleksandr, Lushnikov Eugeny, Roumiantsev Pavel, Matsumoto Naomichi, Nakashima Masahiro, Meirmanov Serik, Ohtsuru Akira, Namba Hiroyuki, Tsyb Anatoly, Yamashita Shunichi", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "12787916", "url": "https://glygen.org/publication/PubMed/12787916" } ] }, { "title": "The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Dho SH, Kwon KS", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "12807881", "url": "https://glygen.org/publication/PubMed/12807881" } ] }, { "title": "RFP is a DNA binding protein associated with the nuclear matrix.", "journal": "Nucleic Acids Res.", "date": "1992", "authors": "Isomura T, Tamiya-Koizumi K, Suzuki M, Yoshida S, Taniguchi M, Matsuyama M, Ishigaki T, Sakuma S, Takahashi M", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "1437549", "url": "https://glygen.org/publication/PubMed/1437549" } ] }, { "title": "Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Shimono Yohei, Murakami Hideki, Kawai Kumi, Wade Paul A, Shimokata Kaoru, Takahashi Masahide", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "14530259", "url": "https://glygen.org/publication/PubMed/14530259" } ] }, { "title": "Selective ablation of retinoblastoma protein function by the RET finger protein.", "journal": "Mol. 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Cell. Biol.", "date": "1987", "authors": "Takahashi M, Cooper GM", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "3037315", "url": "https://glygen.org/publication/PubMed/3037315" } ] }, { "title": "TRIM27 Promotes Hepatitis C Virus Replication by Suppressing Type I Interferon Response.", "journal": "Inflammation", "date": "2019", "authors": "Zheng Feng, Xu Nannan, Zhang Yajun", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "30847745", "url": "https://glygen.org/publication/PubMed/30847745" } ] }, { "title": "Developmentally regulated expression of a human 'finger'-containing gene encoded by the 5' half of the ret transforming gene.", "journal": "Mol. Cell. Biol.", "date": "1988", "authors": "Takahashi M, Inaguma Y, Hiai H, Hirose F", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "3380101", "url": "https://glygen.org/publication/PubMed/3380101" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P14373", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P14373" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.", "journal": "The EMBO journal", "date": "2022", "authors": "Yang Y, Zhu Y, Zhou S, Tang P, Xu R, Zhang Y, Wei D, Wen J, Thorne RF, Zhang XD, Guan JL, Liu L, Wu M, Chen S", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "35670107", "url": "https://glygen.org/publication/PubMed/35670107" } ] }, { "title": "TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.", "journal": "The FEBS journal", "date": "2023-02", "authors": "Garcia-Garcia Juncal, Berge Anne Kristin McLaren, Over\u00e5 Katrine Stange, Larsen Kenneth Bowitz, Bhujabal Zambarlal, Brech Andreas, Abudu Yakubu Princely, Lamark Trond, Johansen Terje, Sj\u00f8ttem Eva", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "36111389", "url": "https://glygen.org/publication/PubMed/36111389" } ] }, { "title": "Analysis of TRIM27 prognosis value and immune infiltrates in hepatocellular carcinoma.", "journal": "International journal of immunopathology and pharmacology", "date": "2022", "authors": "Wang Haichuan, Zhang Yu, Yan Li, Lv Qiang, Lu Jie, Yun Bei", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" } ], "reference": [ { "type": "PubMed", "id": "36217828", "url": "https://glygen.org/publication/PubMed/36217828" } ] }, { "title": "CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.", "journal": "Human genetics", "date": "2022-12-20", "authors": "Smits Daphne J, Dekker Jordy, Schot Rachel, Tabarki Brahim, Alhashem Amal, Demmers Jeroen A A, Dekkers Dick H W, Romito Antonio, van der Spek Peter J, van Ham Tjakko J, Bertoli-Avella Aida M, Mancini Grazia M S", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" } ], "reference": [ { "type": "PubMed", "id": "36538041", "url": "https://glygen.org/publication/PubMed/36538041" } ] }, { "title": "TRIM27 expression is associated with poor prognosis in sinonasal mucosal melanoma.", "journal": "Rhinology", "date": "2023-03-09", "authors": "Kimura S, Suzuki M, Nakamaru Y, Kano S, Watanabe M, Honma A, Nakazono A, Tsushima N, Hatakeyama S, Homma A", "evidence": [ { "database": "RefSeq", "id": "NP_006501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006501" } ], "reference": [ { "type": "PubMed", "id": "36891983", "url": "https://glygen.org/publication/PubMed/36891983" } ] }, { "title": "Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution.", "journal": "J. Cell Sci.", "date": "1997", "authors": "Cao T, Borden K L, Freemont P S, Etkin L D", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "9247190", "url": "https://glygen.org/publication/PubMed/9247190" } ] }, { "title": "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.", "journal": "J. Cell Sci.", "date": "1998", "authors": "Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "reference": [ { "type": "PubMed", "id": "9570750", "url": "https://glygen.org/publication/PubMed/9570750" } ] } ], "pathway": [ { "id": "hsa:5987", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5987", "resource": "KEGG Pathway" }, { "id": "R-HSA-3232142", "name": "SUMOylation of ubiquitinylation proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232142", "resource": "Reactome", "description": "SUMOylation of ubiquitinylation proteins" }, { "id": "R-HSA-8948751", "name": "Regulation of PTEN stability and activity", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-HSA-9635465", "name": "Suppression of apoptosis", "url": 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"name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "positive regulation of actin nucleation", "id": "GO:0051127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051127", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "negative regulation of adaptive immune response", "id": "GO:0002820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002820", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "SUMO transferase activity", "id": "GO:0019789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019789", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" }, { "name": "early endosome", "id": 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"UniProtKB", "id": "P14373", "url": "https://www.uniprot.org/uniprot/P14373" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-HSA-3000434", "name": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1", "equation": "", "summary": "PML TRIM27, PIAS1, and PIAS2-1 can each SUMOylate MDM2 with SUMO1 at lysine-182 (Miyauchi et al. 2002, Chu and Yang 2011). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-HSA-3000408" ], "enzyme_list": [ "P29590-1", "Q00987-1", "P14373-1", "P63279-1", "O75925-1" ], "evidence": [ { "id": "R-HSA-3000434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000434" } ] }, { "id": "R-HSA-8850997", "name": "TRIM27 binds PTEN", "equation": "", "summary": "TRIM27 (RFP) binds PTEN. The interaction involves the C-terminal RFP domain of TRIM27 and the C-terminal tail of PTEN (Lee et al. 2013).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P14373-1", "P60484-1" ], "evidence": [ { "id": "R-HSA-8850997", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850997" } ] }, { "id": "R-HSA-8851011", "name": "TRIM27 polyubiquitinates PTEN", "equation": "", "summary": "TRIM27 (RFP) is an E3 ubiquitin ligase for PTEN. TRIM27 polyubiquitinates PTEN on multiple lysines in the C2 domain of PTEN using K27-linkage between ubiquitin molecules. TRIM27-mediated ubiquitination inhibits PTEN lipid phosphatase activity, but does not affect PTEN protein localization or stability (Lee et al. 2013).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P14373-1", "P60484-1" ], "evidence": [ { "id": "R-HSA-8851011", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8851011" } ] }, { "id": "R-HSA-9636297", "name": "PtpA binds TRIM27", "equation": "", "summary": "Mtb protein tyrosine phosphatase (PtpA) binds to human zinc finger protein RFP (TRIM27) and blocks its activity (Wang et al. 2016).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P14373-1" ], "evidence": [ { "id": "R-HSA-9636297", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9636297" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-3000408", "participant_name": 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