{ "uniprot_canonical_ac": "P13726-1", "uniprot_ac": "P13726", "uniprot_id": "TF_HUMAN", "mass": { "chemical_mass": 33068.0, "monoisotopic_mass": 33068.0 }, "refseq": { "ac": "NP_001171567", "name": "tissue factor isoform 2 precursor", "summary": "This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" }, "gene_names": [ { "name": "F3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P13726", "id": "P13726" }, { "name": "CD142; TF; TFA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567", "id": "NP_001171567" }, { "name": "F3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567", "id": "NP_001171567" } ], "protein_names": [ { "name": "Tissue factor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P13726" }, { "name": "Coagulation factor III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13726" }, { "name": "TF", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13726" }, { "name": "Thromboplastin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13726" }, { "name": "coagulation factor III (thromboplastin, tissue factor)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567", "id": "NP_001171567" }, { "name": "tissue factor isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567", "id": "NP_001171567" } ], "function": [ { "annotation": "Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity.", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" }, { "database": "PubMed", "id": "37589138", "url": "https://glygen.org/publication/PubMed/37589138" } ] }, { "annotation": "Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" }, { "database": "PubMed", "id": "38069209", "url": "https://glygen.org/publication/PubMed/38069209" } ] }, { "annotation": "Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726#function" }, { "database": "PubMed", "id": "12652293", "url": "https://glygen.org/publication/PubMed/12652293" } ] }, { "annotation": "This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020].", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" } ] }, { "annotation": "Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" }, { "database": "PubMed", "id": "37583699", "url": "https://glygen.org/publication/PubMed/37583699" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs754991796", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754991796" }, { "id": "rs754991796", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754991796" }, { "id": "rs754991796", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs754991796#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 169, "end_pos": 169, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNT->KNT).", "chr_id": "1", "chr_pos": "94533174", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N169", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs752548010", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752548010" }, { "id": "rs752548010", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752548010" }, { "id": "rs752548010", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs752548010" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 169, "end_pos": 169, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNT->SNT).", "chr_id": "1", "chr_pos": "94533175", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N169", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1037074934", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1037074934" }, { "id": "rs1037074934", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1037074934" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 191, "end_pos": 191, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KSS->NSS).", "chr_id": "1", "chr_pos": "94533108", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K191", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1233881814", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1233881814" }, { "id": "rs1233881814", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1233881814" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 197, "end_pos": 197, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KKT->NKT).", "chr_id": "1", "chr_pos": "94533090", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K197", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P13726", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P13726" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 233, "end_pos": 233, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KST->NST).", "chr_id": "1", "chr_pos": "94532373", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "K233", "disease": [ { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs143872295", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs143872295" }, { "id": "rs143872295", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs143872295" }, { "id": "rs143872295", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs143872295#frequency_tab" }, { "id": "rs143872295", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs143872295" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 291, "end_pos": 291, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSP->NSS).", "chr_id": "1", "chr_pos": "94530477", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P291", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs889609187", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs889609187" }, { "id": "rs889609187", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs889609187#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 52, "end_pos": 52, "sequence_org": "K", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFK->NFT).", "chr_id": "1", "chr_pos": "94540314", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K52", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1268221929", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1268221929" }, { "id": "rs1268221929", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1268221929" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 90, "end_pos": 90, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLT->NLT).", "chr_id": "1", "chr_pos": "94536109", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D90", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "76.07", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "95.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "88.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "84.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "98.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "97.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "86.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "90.08", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "95.27", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "94.27", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "77.42", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "96.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "94.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117525", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117525" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P13726", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13726" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": 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"https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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carcinoma cells identified by microarray analysis.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Svaren J, Ehrig T, Abdulkadir SA, Ehrengruber MU, Watson MA, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10984481", "url": "https://glygen.org/publication/PubMed/10984481" } ] }, { "title": "The human transcriptional repressor protein NAB1: expression and biological activity.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Thiel G, Kaufmann K, Magin A, Lietz M, Bach K, Cramer M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11018254", "url": "https://glygen.org/publication/PubMed/11018254" } ] }, { "title": "Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Nogueira MM, Mitjavila-Garcia MT, Le Pesteur F, Filippi MD, Vainchenker W, Dubart Kupperschmitt A, Sainteny F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11027551", "url": "https://glygen.org/publication/PubMed/11027551" } ] }, { "title": "Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.", "journal": "Cancer research", "date": "2001", "authors": "Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, Moyers JS, Watson PH, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11280768", "url": "https://glygen.org/publication/PubMed/11280768" } ] }, { "title": "ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.", "journal": "Nature cell biology", "date": "2001", "authors": "Harada T, Morooka T, Ogawa S, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11331872", "url": "https://glygen.org/publication/PubMed/11331872" } ] }, { "title": "Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation.", "journal": "Neuron", "date": "2001", "authors": "Steward O, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11343657", "url": "https://glygen.org/publication/PubMed/11343657" } ] }, { "title": "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma.", "journal": "Human pathology", "date": "2001", "authors": "Abdulkadir SA, Carbone JM, Naughton CK, Humphrey PA, Catalona WJ, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11567222", "url": "https://glygen.org/publication/PubMed/11567222" } ] }, { "title": "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction.", "journal": "FEBS letters", "date": "2002", "authors": "Mandolesi G, Gargano S, Pennuto M, Illi B, Molfetta R, Soucek L, Mosca L, Levi A, Jucker R, Nasi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11755530", "url": "https://glygen.org/publication/PubMed/11755530" } ] }, { "title": "The regulation and function of the Id proteins in lymphocyte development.", "journal": "Oncogene", "date": "2001", "authors": "Rivera R, Murre C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11840323", "url": "https://glygen.org/publication/PubMed/11840323" } ] }, { "title": "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11956230", "url": "https://glygen.org/publication/PubMed/11956230" } ] }, { "title": "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.", "journal": "Science (New York, N.Y.)", "date": "2002", "authors": "Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "12399542", "url": "https://glygen.org/publication/PubMed/12399542" } ] }, { "title": "Synthesis of serotonin by a second tryptophan hydroxylase isoform.", "journal": "Science (New York, N.Y.)", "date": "2003", "authors": "Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "12511643", "url": "https://glygen.org/publication/PubMed/12511643" } ] }, { "title": "Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein.", "journal": "Nature medicine", "date": "2003-04", "authors": "Bogdanov Vladimir Y, Balasubramanian Viji, Hathcock James, Vele Oana, Lieb Mark, Nemerson Yale", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "12652293", "url": "https://glygen.org/publication/PubMed/12652293" } ] }, { "title": "Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation.", "journal": "Blood", "date": "2003", "authors": "Dorfleutner A, Ruf W", "evidence": [ { "database": "iPTMnet", "id": "P13726", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P13726" } ], "reference": [ { "type": "PubMed", "id": "12920028", "url": "https://glygen.org/publication/PubMed/12920028" } ] }, { "title": "NGF induces the expression of the VGF gene through a cAMP response element.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "1992", "authors": "Hawley RJ, Scheibe RJ, Wagner JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1377233", "url": "https://glygen.org/publication/PubMed/1377233" } ] }, { "title": "Local regulation of fat metabolism in peripheral nerves.", "journal": "Genes & development", "date": "2003", "authors": "Verheijen MH, Chrast R, Burrola P, Lemke G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "14522948", "url": "https://glygen.org/publication/PubMed/14522948" } ] }, { "title": "Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, Dandolo L, Hamon M, Mallet J, Vodjdani G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "14597720", "url": "https://glygen.org/publication/PubMed/14597720" } ] }, { "title": "Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC).", "journal": "Brain research. Molecular brain research", "date": "2004", "authors": "Teber I, Kohling R, Speckmann EJ, Barnekow A, Kremerskothen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "14969744", "url": "https://glygen.org/publication/PubMed/14969744" } ] }, { "title": "Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Ahamed J, Ruf W", "evidence": [ { "database": "iPTMnet", "id": "P13726", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P13726" } ], "reference": [ { "type": "PubMed", "id": "15039423", "url": "https://glygen.org/publication/PubMed/15039423" } ] }, { "title": "Rho kinase regulates schwann cell myelination and formation of associated axonal domains.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2004", "authors": "Melendez-Vasquez CV, Einheber S, Salzer JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15102911", "url": "https://glygen.org/publication/PubMed/15102911" } ] }, { "title": "Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Yamauchi J, Chan JR, Shooter EM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15161978", "url": "https://glygen.org/publication/PubMed/15161978" } ] }, { "title": "Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.", "journal": "Journal of cellular biochemistry", "date": "2004", "authors": "Chen CC, Lee WR, Safe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15449318", "url": "https://glygen.org/publication/PubMed/15449318" } ] }, { "title": "Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LA, O'donnell A, Hayes A, Sharrocks AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15542842", "url": "https://glygen.org/publication/PubMed/15542842" } ] }, { "title": "Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.", "journal": "Cell", "date": "2004", "authors": "Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, Goodman RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15620361", "url": "https://glygen.org/publication/PubMed/15620361" } ] }, { "title": "Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Possenti R, Di Rocco G, Nasi S, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1570299", "url": "https://glygen.org/publication/PubMed/1570299" } ] }, { "title": "Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.", "journal": "FEBS letters", "date": "2005", "authors": "David S, Kalb RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15733869", "url": "https://glygen.org/publication/PubMed/15733869" } ] }, { "title": "Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination.", "journal": "Journal of neurochemistry", "date": "2005", "authors": "Leblanc SE, Srinivasan R, Ferri C, Mager GM, Gillian-Daniel AL, Wrabetz L, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15836632", "url": "https://glygen.org/publication/PubMed/15836632" } ] }, { "title": "SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability.", "journal": "Nature neuroscience", "date": "2005", "authors": "Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schutz G, Linden DJ, Ginty DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15880109", "url": "https://glygen.org/publication/PubMed/15880109" } ] }, { "title": "Id family of helix-loop-helix proteins in cancer.", "journal": "Nature reviews. Cancer", "date": "2005", "authors": "Perk J, Iavarone A, Benezra R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16034366", "url": "https://glygen.org/publication/PubMed/16034366" } ] }, { "title": "Nab proteins are essential for peripheral nervous system myelination.", "journal": "Nature neuroscience", "date": "2005", "authors": "Le N, Nagarajan R, Wang JY, Svaren J, LaPash C, Araki T, Schmidt RE, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16136673", "url": "https://glygen.org/publication/PubMed/16136673" } ] }, { "title": "BMP enhances transcriptional responses to NGF during PC12 cell differentiation.", "journal": "Neurochemical research", "date": "2005", "authors": "Lonn P, Zaia K, Israelsson C, Althini S, Usoskin D, Kylberg A, Ebendal T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16187211", "url": "https://glygen.org/publication/PubMed/16187211" } ] }, { "title": "A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16221685", "url": "https://glygen.org/publication/PubMed/16221685" } ] }, { "title": "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kumbrink J, Gerlinger M, Johnson JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16260776", "url": "https://glygen.org/publication/PubMed/16260776" } ] }, { "title": "The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Li L, Carter J, Gao X, Whitehead J, Tourtellotte WG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16287845", "url": "https://glygen.org/publication/PubMed/16287845" } ] }, { "title": "Immediate-early gene-encoded protein Arc is associated with synaptic delivery of GluR4-containing AMPA receptors during in vitro classical conditioning.", "journal": "Journal of neurophysiology", "date": "2006", "authors": "Mokin M, Lindahl JS, Keifer J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16339507", "url": "https://glygen.org/publication/PubMed/16339507" } ] }, { "title": "Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2006", "authors": "Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16407550", "url": "https://glygen.org/publication/PubMed/16407550" } ] }, { "title": "Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16484497", "url": "https://glygen.org/publication/PubMed/16484497" } ] }, { "title": "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Srinivasan R, Mager GM, Ward RM, Mayer J, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16574654", "url": "https://glygen.org/publication/PubMed/16574654" } ] }, { "title": "AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc.", "journal": "Nature neuroscience", "date": "2006", "authors": "Rao VR, Pintchovski SA, Chin J, Peebles CL, Mitra S, Finkbeiner S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16732277", "url": "https://glygen.org/publication/PubMed/16732277" } ] }, { "title": "Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.", "journal": "Neuron", "date": "2006", "authors": "Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Grant SG, Bliss TV, Wolfer DP, Kuhl D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17088210", "url": "https://glygen.org/publication/PubMed/17088210" } ] }, { "title": "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.", "journal": "Neuron", "date": "2006", "authors": "Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17088211", "url": "https://glygen.org/publication/PubMed/17088211" } ] }, { "title": "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission.", "journal": "Neuron", "date": "2006", "authors": "Rial Verde EM, Lee-Osbourne J, Worley PF, Malinow R, Cline HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17088212", "url": "https://glygen.org/publication/PubMed/17088212" } ] }, { "title": "The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Zioncheck TF, Roy S, Vehar GA", "evidence": [ { "database": "iPTMnet", "id": "P13726-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P13726-1" } ], "reference": [ { "type": "PubMed", "id": "1740409", "url": "https://glygen.org/publication/PubMed/1740409" } ] }, { "title": "The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression.", "journal": "Cell", "date": "2007", "authors": "Giorgi C, Yeo GW, Stone ME, Katz DB, Burge C, Turrigiano G, Moore MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17632064", "url": "https://glygen.org/publication/PubMed/17632064" } ] }, { "title": "Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2007", "authors": "Messaoudi E, Kanhema T, Soule J, Tiron A, Dagyte G, da Silva B, Bramham CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17898216", "url": "https://glygen.org/publication/PubMed/17898216" } ] }, { "title": "Rad GTPase deficiency leads to cardiac hypertrophy.", "journal": "Circulation", "date": "2007", "authors": "Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Bruning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18056528", "url": "https://glygen.org/publication/PubMed/18056528" } ] }, { "title": "Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation.", "journal": "Journal of neurochemistry", "date": "2008", "authors": "Tyan SW, Tsai MC, Lin CL, Ma YL, Lee EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18088355", "url": "https://glygen.org/publication/PubMed/18088355" } ] }, { "title": "Lyl1 interacts with CREB1 and alters expression of CREB1 target genes.", "journal": "Biochimica et biophysica acta", "date": "2008", "authors": "San-Marina S, Han Y, Suarez Saiz F, Trus MR, Minden MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18160048", "url": "https://glygen.org/publication/PubMed/18160048" } ] }, { "title": "Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements.", "journal": "Oncogene", "date": "1991", "authors": "Alexandre C, Charnay P, Verrier B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1833716", "url": "https://glygen.org/publication/PubMed/1833716" } ] }, { "title": "Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Mager GM, Ward RM, Srinivasan R, Jang SW, Wrabetz L, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18456662", "url": "https://glygen.org/publication/PubMed/18456662" } ] }, { "title": "Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2008", "authors": "Desmazieres A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18524893", "url": "https://glygen.org/publication/PubMed/18524893" } ] }, { "title": "Nucleotide sequence and regulatory studies of VGF, a nervous system-specific mRNA that is rapidly and relatively selectively induced by nerve growth factor.", "journal": "Journal of neurochemistry", "date": "1991", "authors": "Salton SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1861162", "url": "https://glygen.org/publication/PubMed/1861162" } ] }, { "title": "Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Ruf W, Kalnik MW, Lund-Hansen T, Edgington TS", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "1874730", "url": "https://glygen.org/publication/PubMed/1874730" } ] }, { "title": "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.", "journal": "Molecular cell", "date": "2008", "authors": "Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19061646", "url": "https://glygen.org/publication/PubMed/19061646" } ] }, { "title": "Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19116276", "url": "https://glygen.org/publication/PubMed/19116276" } ] }, { "title": "Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.", "journal": "Circ. Res.", "date": "2009", "authors": "Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S, Poller W, Schultheiss HP, Rauch U", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "19168442", "url": "https://glygen.org/publication/PubMed/19168442" } ] }, { "title": "The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2009", "authors": "Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19193899", "url": "https://glygen.org/publication/PubMed/19193899" } ] }, { "title": "Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2009", "authors": "Toshinai K, Nakazato M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19194657", "url": "https://glygen.org/publication/PubMed/19194657" } ] }, { "title": "Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.", "journal": "Circulation research", "date": "2010", "authors": "Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19926875", "url": "https://glygen.org/publication/PubMed/19926875" } ] }, { "title": "Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells.", "journal": "Molecular and cellular biology", "date": "1991", "authors": "Salton SR, Fischberg DJ, Dong KW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2017159", "url": "https://glygen.org/publication/PubMed/2017159" } ] }, { "title": "v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Qureshi SA, Cao XM, Sukhatme VP, Foster DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2040600", "url": "https://glygen.org/publication/PubMed/2040600" } ] }, { "title": "Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Lawson JH, Mann KG", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "2040636", "url": "https://glygen.org/publication/PubMed/2040636" } ] }, { "title": "EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.", "journal": "Journal of cellular biochemistry", "date": "2010", "authors": "Kumbrink J, Kirsch KH, Johnson JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "20506119", "url": "https://glygen.org/publication/PubMed/20506119" } ] }, { "title": "5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.", "journal": "Oncogene", "date": "1991", "authors": "Sakamoto KM, Bardeleben C, Yates KE, Raines MA, Golde DW, Gasson JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2052361", "url": "https://glygen.org/publication/PubMed/2052361" } ] }, { "title": "Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.", "journal": "Haematologica", "date": "2010", "authors": "Nadir Yona, Brenner Benjamin, Fux Liat, Shafat Itay, Attias Judith, Vlodavsky Israel", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "20634491", "url": "https://glygen.org/publication/PubMed/20634491" } ] }, { "title": "The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.", "journal": "Molecular and cellular biology", "date": "1991", "authors": "Crosby SD, Puetz JJ, Simburger KS, Fahrner TJ, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2072895", "url": "https://glygen.org/publication/PubMed/2072895" } ] }, { "title": "Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity.", "journal": "Communicative & integrative biology", "date": "2010", "authors": "Inoue M, Yagishita-Kyo N, Nonaka M, Kawashima T, Okuno H, Bito H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21057636", "url": "https://glygen.org/publication/PubMed/21057636" } ] }, { "title": "Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.", "journal": "Molecular and cellular biology", "date": "1990", "authors": "Cao XM, Koski RA, Gashler A, McKiernan M, Morris CF, Gaffney R, Hay RV, Sukhatme VP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2109185", "url": "https://glygen.org/publication/PubMed/2109185" } ] }, { "title": "Activation and function of immediate-early genes in the nervous system.", "journal": "Biochemistry and cell biology = Biochimie et biologie cellulaire", "date": "2011", "authors": "Perez-Cadahia B, Drobic B, Davie JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21326363", "url": "https://glygen.org/publication/PubMed/21326363" } ] }, { "title": "ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis.", "journal": "Journal of cell science", "date": "2011", "authors": "Hong SH, Lee JH, Lee JB, Ji J, Bhatia M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21486943", "url": "https://glygen.org/publication/PubMed/21486943" } ] }, { "title": "VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers.", "journal": "Journal of chemical neuroanatomy", "date": "2011", "authors": "Ferri GL, Noli B, Brancia C, D'Amato F, Cocco C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21621608", "url": "https://glygen.org/publication/PubMed/21621608" } ] }, { "title": "Early growth response 1--a transcription factor in the crossfire of signal transduction cascades.", "journal": "Indian journal of biochemistry & biophysics", "date": "2011", "authors": "Pagel JI, Deindl E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "22053691", "url": "https://glygen.org/publication/PubMed/22053691" } ] }, { "title": "Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Mullenbrock S, Shah J, Cooper GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "22065583", "url": "https://glygen.org/publication/PubMed/22065583" } ] }, { "title": "The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2012", "authors": "Hung H, Kohnken R, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "22302795", "url": "https://glygen.org/publication/PubMed/22302795" } ] }, { "title": "Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.", "journal": "Thrombosis research", "date": "1990", "authors": "Fleck RA, Rao LV, Rapaport SI, Varki N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2237820", "url": "https://glygen.org/publication/PubMed/2237820" } ] }, { "title": "Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor.", "journal": "Biochemistry", "date": "1990", "authors": "Komiyama Y, Pedersen AH, Kisiel W", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "2248955", "url": "https://glygen.org/publication/PubMed/2248955" } ] }, { "title": "Structural biology of factor VIIa/tissue factor initiated coagulation.", "journal": "Frontiers in bioscience (Landmark edition)", "date": "2012", "authors": "Vadivel K, Bajaj SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "22652793", "url": "https://glygen.org/publication/PubMed/22652793" } ] }, { "title": "Regulation of coagulation by a multivalent Kunitz-type inhibitor.", "journal": "Biochemistry", "date": "1990", "authors": "Broze GJ Jr, Girard TJ, Novotny WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "2271516", "url": "https://glygen.org/publication/PubMed/2271516" } ] }, { "title": "Regulation of tissue factor coagulant activity on cell surfaces.", "journal": "Journal of thrombosis and haemostasis : JTH", "date": "2012", "authors": "Rao LV, Pendurthi UR", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "23006890", "url": "https://glygen.org/publication/PubMed/23006890" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "p38alpha phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles.", "journal": "Biochimica et biophysica acta", "date": "2013", "authors": "Ettelaie C, Elkeeb AM, Maraveyas A, Collier ME", "evidence": [ { "database": "iPTMnet", "id": "P13726", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P13726" } ], "reference": [ { "type": "PubMed", "id": "23195225", "url": "https://glygen.org/publication/PubMed/23195225" } ] }, { "title": "Analysis of tissue factor expression in various cell model systems: cryptic vs. active.", "journal": "Journal of thrombosis and haemostasis : JTH", "date": "2013", "authors": "Kothari H, Pendurthi UR, Rao LV", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "23621622", "url": "https://glygen.org/publication/PubMed/23621622" } ] }, { "title": "Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes.", "journal": "The American journal of gastroenterology", "date": "2013", "authors": "Grasberger H, Chang L, Shih W, Presson AP, Sayuk GS, Newberry RD, Karagiannides I, Pothoulakis C, Mayer E, Merchant JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "24060757", "url": "https://glygen.org/publication/PubMed/24060757" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Id proteins: small molecules, mighty regulators.", "journal": "Current topics in developmental biology", "date": "2014", "authors": "Ling F, Kang B, Sun XH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "25248477", "url": "https://glygen.org/publication/PubMed/25248477" } ] }, { "title": "Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.", "journal": "Neuroreport", "date": "2015", "authors": "Moon SM, Kim JS, Park BR, Kim DK, Kim SG, Kim HJ, Chun HS, Lee BK, Kim CS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "25569790", "url": "https://glygen.org/publication/PubMed/25569790" } ] }, { "title": "Arc is a flexible modular protein capable of reversible self-oligomerization.", "journal": "The Biochemical journal", "date": "2015", "authors": "Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuellar J, Haavik J, Soule J, Valpuesta JM, Marquez JA, Martinez A, Bramham CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "25748042", "url": "https://glygen.org/publication/PubMed/25748042" } ] }, { "title": "How it all starts: Initiation of the clotting cascade.", "journal": "Critical reviews in biochemistry and molecular biology", "date": "2015", "authors": "Smith SA, Travers RJ, Morrissey JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "26018600", "url": "https://glygen.org/publication/PubMed/26018600" } ] }, { "title": "A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway.", "journal": "The EMBO journal", "date": "1989", "authors": "Possenti R, Eldridge JD, Paterson BM, Grasso A, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2676516", "url": "https://glygen.org/publication/PubMed/2676516" } ] }, { "title": "Structural Basis for Substrate Selectivity of the E3 Ligase COP1.", "journal": "Structure (London, England : 1993)", "date": "2016", "authors": "Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "27041596", "url": "https://glygen.org/publication/PubMed/27041596" } ] }, { "title": "Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1989", "authors": "Wilcox JN, Smith KM, Schwartz SM, Gordon D", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "2704749", "url": "https://glygen.org/publication/PubMed/2704749" } ] }, { "title": "Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances.", "journal": "PloS one", "date": "2016", "authors": "Zhao Q, Chang C, Gonzalez JP, Alzahrani K, Button JL, Fraidenraich D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "27128622", "url": "https://glygen.org/publication/PubMed/27128622" } ] }, { "title": "Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade.", "journal": "Biochemistry", "date": "1989", "authors": "Mackman N, Morrissey JH, Fowler B, Edgington TS", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "2719931", "url": "https://glygen.org/publication/PubMed/2719931" } ] }, { "title": "Gene regulation in the immediate-early response process.", "journal": "Advances in biological regulation", "date": "2016", "authors": "Bahrami S, Drablos F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "27220739", "url": "https://glygen.org/publication/PubMed/27220739" } ] }, { "title": "Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells.", "journal": "PloS one", "date": "2017", "authors": "Adams KW, Kletsov S, Lamm RJ, Elman JS, Mullenbrock S, Cooper GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "28076410", "url": "https://glygen.org/publication/PubMed/28076410" } ] }, { "title": "Human tissue factor: cDNA sequence and chromosome localization of the gene.", "journal": "Biochemistry", "date": "1987", "authors": "Scarpati EM, Wen D, Broze GJ Jr, Miletich JP, Flandermeyer RR, Siegel NR, Sadler JE", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "2823875", "url": "https://glygen.org/publication/PubMed/2823875" } ] }, { "title": "Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.", "journal": "The Biochemical journal", "date": "2017", "authors": "Hooker E, Baldwin C, Roodman V, Batra A, Isa NN, Takano T, Lemay S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "28275114", "url": "https://glygen.org/publication/PubMed/28275114" } ] }, { "title": "ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription.", "journal": "Molecular cell", "date": "2017", "authors": "Esnault C, Gualdrini F, Horswell S, Kelly G, Stewart A, East P, Matthews N, Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "28286024", "url": "https://glygen.org/publication/PubMed/28286024" } ] }, { "title": "Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2018", "authors": "Grover SP, Mackman N", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "29437578", "url": "https://glygen.org/publication/PubMed/29437578" } ] }, { "title": "The Arc of cognition: Signaling cascades regulating Arc and implications for cognitive function and disease.", "journal": "Seminars in cell & developmental biology", "date": "2018", "authors": "Epstein I, Finkbeiner S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "29559111", "url": "https://glygen.org/publication/PubMed/29559111" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "GlyConnect", "id": "1811", "url": "https://glyconnect.expasy.org/browser/proteins/1811" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "title": "Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Spicer E K, Horton R, Bloem L, Bach R, Williams K R, Guha A, Kraus J, Lin T C, Nemerson Y, Konigsberg W H", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "3037536", "url": "https://glygen.org/publication/PubMed/3037536" } ] }, { "title": "Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.", "journal": "Biophysical journal", "date": "2019", "authors": "Sorensen AB, Madsen JJ, Frimurer TM, Overgaard MT, Gandhi PS, Persson E, Olsen OH", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "31003762", "url": "https://glygen.org/publication/PubMed/31003762" } ] }, { "title": "A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.", "journal": "Cell", "date": "1988", "authors": "Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "3127059", "url": "https://glygen.org/publication/PubMed/3127059" } ] }, { "title": "Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine.", "journal": "Biochemistry", "date": "1988", "authors": "Bach R, Konigsberg W H, Nemerson Y", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "3166978", "url": "https://glygen.org/publication/PubMed/3166978" } ] }, { "title": "Tissue factor and hemostasis.", "journal": "Blood", "date": "1988", "authors": "Nemerson Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "3275472", "url": "https://glygen.org/publication/PubMed/3275472" } ] }, { "title": "Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade.", "journal": "Cell", "date": "1987", "authors": "Morrissey J H, Fakhrai H, Edgington T S", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "3297348", "url": "https://glygen.org/publication/PubMed/3297348" } ] }, { "title": "Cloning and expression of human tissue factor cDNA.", "journal": "Thromb. Res.", "date": "1987", "authors": "Fisher K L, Gorman C M, Vehar G A, O'Brien D P, Lawn R M", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "3424286", "url": "https://glygen.org/publication/PubMed/3424286" } ] }, { "title": "Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine.", "journal": "Biochemistry", "date": "1986", "authors": "Bach R, Gentry R, Nemerson Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "3527261", "url": "https://glygen.org/publication/PubMed/3527261" } ] }, { "title": "A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.", "journal": "Science (New York, N.Y.)", "date": "1987", "authors": "Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "3672127", "url": "https://glygen.org/publication/PubMed/3672127" } ] }, { "title": "Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis.", "journal": "Frontiers in immunology", "date": "2023", "authors": "Koudriavtseva Tatiana, Lorenzano Svetlana, Cellerino Maria, Truglio Mauro, Fiorelli Marco, Lapucci Caterina, D'Agosto Giovanna, Conti Laura, Stefanile Annunziata, Zannino Silvana, Filippi Maria Maddalena, Cortese Antonio, Piantadosi Carlo, Maschio Marta, Maialetti Andrea, Gali\u00e8 Edvina, Salvetti Marco, Inglese Matilde", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" } ], "reference": [ { "type": "PubMed", "id": "37583699", "url": "https://glygen.org/publication/PubMed/37583699" } ] }, { "title": "Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2023-10", "authors": "Brambilla Marta, Becchetti Alessia, Rovati Gian Enrico, Cosentino Nicola, Conti Maria, Canzano Paola, Giesen Peter L A, Loffreda Alessia, Bonomi Alice, Cattaneo Marco, De Candia Erica, Podda Gian Marco, Trabattoni Daniela, Werba Pablo Jos\u00e8, Campodonico Jeness, Pinna Christian, Marenzi Giancarlo, Tremoli Elena, Camera Marina", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" } ], "reference": [ { "type": "PubMed", "id": "37589138", "url": "https://glygen.org/publication/PubMed/37589138" } ] }, { "title": "Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19.", "journal": "International journal of molecular sciences", "date": "2023-11-28", "authors": "Eichhorn Tanja, Weiss Ren\u00e9, Huber Silke, Ebeyer-Masotta Marie, Mostageer Marwa, Emprechtinger Robert, Knabl Ludwig, Knabl Ludwig, W\u00fcrzner Reinhard, Weber Viktoria", "evidence": [ { "database": "RefSeq", "id": "NP_001171567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567" } ], "reference": [ { "type": "PubMed", "id": "38069209", "url": "https://glygen.org/publication/PubMed/38069209" } ] }, { "title": "Binding of human factor VII and VIIa to monocytes.", "journal": "The Journal of clinical investigation", "date": "1982", "authors": "Broze GJ Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "6980899", "url": "https://glygen.org/publication/PubMed/6980899" } ] }, { "title": "Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.", "journal": "Molecular and cellular neurosciences", "date": "1995", "authors": "Bonni A, Ginty DD, Dudek H, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7551568", "url": "https://glygen.org/publication/PubMed/7551568" } ] }, { "title": "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7592934", "url": "https://glygen.org/publication/PubMed/7592934" } ] }, { "title": "Tissue-specific processing of the neuroendocrine protein VGF.", "journal": "Journal of neurochemistry", "date": "1995", "authors": "Trani E, Ciotti T, Rinaldi AM, Canu N, Ferri GL, Levi A, Possenti R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7595538", "url": "https://glygen.org/publication/PubMed/7595538" } ] }, { "title": "Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Lee HJ, Mignacca RC, Sakamoto KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7608156", "url": "https://glygen.org/publication/PubMed/7608156" } ] }, { "title": "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Russo MW, Sevetson BR, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7624335", "url": "https://glygen.org/publication/PubMed/7624335" } ] }, { "title": "Somatodendritic expression of an immediate early gene is regulated by synaptic activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Link W, Konietzko U, Kauselmann G, Krug M, Schwanke B, Frey U, Kuhl D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7777577", "url": "https://glygen.org/publication/PubMed/7777577" } ] }, { "title": "A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "McMahon SB, Monroe JG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7823924", "url": "https://glygen.org/publication/PubMed/7823924" } ] }, { "title": "Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.", "journal": "Neuron", "date": "1995", "authors": "Lyford GL, Yamagata K, Kaufmann WE, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7857651", "url": "https://glygen.org/publication/PubMed/7857651" } ] }, { "title": "The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.", "journal": "Science (New York, N.Y.)", "date": "1995", "authors": "Schoenherr CJ, Anderson DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7871435", "url": "https://glygen.org/publication/PubMed/7871435" } ] }, { "title": "Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Zhu J, Reynet C, Caldwell JS, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7876254", "url": "https://glygen.org/publication/PubMed/7876254" } ] }, { "title": "Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.", "journal": "Cell", "date": "1994", "authors": "Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7923378", "url": "https://glygen.org/publication/PubMed/7923378" } ] }, { "title": "Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site.", "journal": "Biochemistry", "date": "1994", "authors": "Muller Y A, Ultsch M H, Kelley R F, de Vos A M", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "8086403", "url": "https://glygen.org/publication/PubMed/8086403" } ] }, { "title": "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.", "journal": "Nature", "date": "1994", "authors": "Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8090221", "url": "https://glygen.org/publication/PubMed/8090221" } ] }, { "title": "A brain-specific activator of cyclin-dependent kinase 5.", "journal": "Nature", "date": "1994", "authors": "Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, Wang JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8090222", "url": "https://glygen.org/publication/PubMed/8090222" } ] }, { "title": "Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.", "journal": "Science (New York, N.Y.)", "date": "1993", "authors": "Reynet C, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8248782", "url": "https://glygen.org/publication/PubMed/8248782" } ] }, { "title": "Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.", "journal": "Molecular and cellular biology", "date": "1993", "authors": "Russo MW, Matheny C, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8413279", "url": "https://glygen.org/publication/PubMed/8413279" } ] }, { "title": "Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "1993", "authors": "DeFranco C, Damon DH, Endoh M, Wagner JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8483478", "url": "https://glygen.org/publication/PubMed/8483478" } ] }, { "title": "Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Cui MZ, Parry GC, Oeth P, Larson H, Smith M, Huang RP, Adamson ED, Mackman N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8576248", "url": "https://glygen.org/publication/PubMed/8576248" } ] }, { "title": "The tissue factor pathway: how it has become a `prima ballerina`.", "journal": "Thrombosis and haemostasis", "date": "1995", "authors": "Rapaport SI, Rao LV", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "8578528", "url": "https://glygen.org/publication/PubMed/8578528" } ] }, { "title": "Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma.", "journal": "The Journal of urology", "date": "1996", "authors": "Thigpen AE, Cala KM, Guileyardo JM, Molberg KH, McConnell JD, Russell DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8583621", "url": "https://glygen.org/publication/PubMed/8583621" } ] }, { "title": "The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.", "journal": "Nature", "date": "1996", "authors": "Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" }, { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "8598903", "url": "https://glygen.org/publication/PubMed/8598903" } ] }, { "title": "The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution.", "journal": "J. Mol. Biol.", "date": "1996", "authors": "Muller Y A, Ultsch M H, de Vos A M", "evidence": [ { "database": "UniProtKB", "id": "P13726", "url": "https://www.uniprot.org/uniprot/P13726" } ], "reference": [ { "type": "PubMed", "id": "8609606", "url": "https://glygen.org/publication/PubMed/8609606" } ] }, { "title": "Kinetics of human factor VII activation.", "journal": "Biochemistry", "date": "1996", "authors": "Butenas S, Mann KG", "evidence": [ { "database": "Reactome", "id": "R-HSA-140834", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834" } ], "reference": [ { "type": "PubMed", "id": "8639673", "url": "https://glygen.org/publication/PubMed/8639673" } ] }, { "title": "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", 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"https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8846918", "url": "https://glygen.org/publication/PubMed/8846918" } ] }, { "title": "The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation.", "journal": "Molecular and cellular neurosciences", "date": "1996", "authors": "Zorick TS, Syroid DE, Arroyo E, Scherer SS, Lemke G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8918830", "url": "https://glygen.org/publication/PubMed/8918830" } ] }, { "title": "Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Di Rocco G, Pennuto M, Illi B, Canu N, Filocamo G, Trani E, Rinaldi AM, Possenti R, Mandolesi G, Sirinian MI, Jucker R, Levi A, Nasi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9032251", "url": "https://glygen.org/publication/PubMed/9032251" } ] }, { "title": "Molecular cloning and characterization of the human VGF promoter region.", "journal": "Journal of neurochemistry", "date": "1997", "authors": "Canu N, Possenti R, Rinaldi AM, Trani E, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9084409", "url": "https://glygen.org/publication/PubMed/9084409" } ] }, { "title": "Role of cyclins in neuronal differentiation of immortalized hippocampal cells.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Xiong W, Pestell R, Rosner MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9343422", "url": "https://glygen.org/publication/PubMed/9343422" } ] }, { "title": "CREB: a major mediator of neuronal neurotrophin responses.", "journal": "Neuron", "date": "1997", "authors": "Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9390517", "url": "https://glygen.org/publication/PubMed/9390517" } ] }, { "title": "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9418898", "url": "https://glygen.org/publication/PubMed/9418898" } ] }, { "title": "Expression of early growth response genes in human prostate cancer.", "journal": "Cancer research", "date": "1998", "authors": "Eid MA, Kumar MV, Iczkowski KA, Bostwick DG, Tindall DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9622090", "url": "https://glygen.org/publication/PubMed/9622090" } ] }, { "title": "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells.", "journal": "The Journal of cell biology", "date": "1998", "authors": "Qu Z, Wolfraim LA, Svaren J, Ehrengruber MU, Davidson N, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9722618", "url": "https://glygen.org/publication/PubMed/9722618" } ] }, { "title": "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "De Cesare D, Jacquot S, Hanauer A, Sassone-Corsi P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9770464", "url": "https://glygen.org/publication/PubMed/9770464" } ] }, { "title": "Novel mutants of NAB corepressors enhance activation by Egr transactivators.", "journal": "The EMBO journal", "date": "1998", "authors": "Svaren J, Sevetson BR, Golda T, Stanton JJ, Swirnoff AH, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": 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