{ "uniprot_canonical_ac": "P13686-1", "uniprot_ac": "P13686", "uniprot_id": "PPA5_HUMAN", "mass": { "chemical_mass": 36599.0, "monoisotopic_mass": 36599.0 }, "refseq": { "ac": "NP_001104504", "name": "tartrate-resistant acid phosphatase type 5 precursor", "summary": "This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" }, "gene_names": [ { "name": "ACP5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P13686", "id": "P13686" }, { "name": "ACP5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504", "id": "NP_001104504" }, { "name": "HPAP; TRAcP; TRACP5a; TRACP5b; TRAP; TrATPase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504", "id": "NP_001104504" } ], "protein_names": [ { "name": "Tartrate-resistant acid phosphatase type 5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P13686" }, { "name": "3.1.3.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13686" }, { "name": "TR-AP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13686" }, { "name": "Tartrate-resistant acid ATPase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13686" }, { "name": "TrATPase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13686" }, { "name": "Type 5 acid phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P13686" }, { "name": "tartrate-resistant acid phosphatase type 5 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504", "id": "NP_001104504" }, { "name": "tartrate-resistant acid phosphatase type 5; tartrate-resistant acid ATPase; human purple acid phosphatase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504", "id": "NP_001104504" } ], "function": [ { "annotation": "Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.", "evidence": [ { "database": "UniProtKB", "id": "P13686", "url": "https://www.uniprot.org/uniprot/P13686#function" } ] }, { "annotation": "Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" }, { "database": "PubMed", "id": "36637040", "url": "https://glygen.org/publication/PubMed/36637040" } ] }, { "annotation": "Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" }, { "database": "PubMed", "id": "37010587", "url": "https://glygen.org/publication/PubMed/37010587" } ] }, { "annotation": "Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" }, { "database": "PubMed", "id": "37382551", "url": "https://glygen.org/publication/PubMed/37382551" } ] }, { "annotation": "Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating beta-catenin signaling. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" }, { "database": "PubMed", "id": "35013220", "url": "https://glygen.org/publication/PubMed/35013220" } ] }, { "annotation": "The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" }, { "database": "PubMed", "id": "35102444", "url": "https://glygen.org/publication/PubMed/35102444" } ] }, { "annotation": "This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" } ] } ], "disease": [ { "disease_id": "MONDO:0011939", "recommended_name": { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "Spondyloenchondrodysplasia with immune dysregulation", "description": "" }, "synonyms": [ { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "Roifman Immunoskeletal syndrome", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "SPENCD", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "SPENCDI", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "Spondyloenchondrodysplasia with immune dysregulation", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "combined immunodeficiency with autoimmunity and spondylometaphyseal dysplasia", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "spondyloenchondrodysplasia", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "spondyloenchondrodysplasia with immune dysregulation", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "spondyloenchondromatosis", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "spondylometaphyseal dysplasia with combined immunodeficiency", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "spondylometaphyseal dysplasia with enchondromatous changes", "description": "" }, { "id": "MONDO:0011939", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011939", "name": "SEM", "description": "" }, { "id": "MIM:607944", "resource": "MIM", "url": "https://www.omim.org/entry/607944", "name": "Spondyloenchondrodysplasia with immune dysregulation", "description": "Spondyloenchondrodysplasia with immune dysregulation" } ], "evidence": [ { "id": "607944", "database": "MIM", "url": "https://www.omim.org/entry/607944" } ] } ], "snv": [ { "evidence": [ { "id": "rs387906670", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs387906670" }, { "id": "rs387906670", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs387906670" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 264, "end_pos": 264, "sequence_org": "M", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFM->NFT).", "chr_id": "19", "chr_pos": "11575197", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "M264", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "85.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "75.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "85.68", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "65.75", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "90.82", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "93.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "67.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "78.28", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "70.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "82.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "76.98", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "87.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "89.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102575", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102575" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the 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"description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P13686", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P13686" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WKS0-1", "url": "https://www.uniprot.org/uniprot/A0A8Q3WKS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WKS1", "url": "https://www.uniprot.org/uniprot/A0A8Q3WKS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WKS1-1", "url": "https://www.uniprot.org/uniprot/A0A8Q3WKS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WKT0", "url": "https://www.uniprot.org/uniprot/A0A8Q3WKT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WKT0-1", "url": "https://www.uniprot.org/uniprot/A0A8Q3WKT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WLB6", "url": "https://www.uniprot.org/uniprot/A0A8Q3WLB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q3WLB6-1", "url": "https://www.uniprot.org/uniprot/A0A8Q3WLB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EIP0", "url": "https://www.uniprot.org/uniprot/K7EIP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EIP0-1", "url": "https://www.uniprot.org/uniprot/K7EIP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EJD9", "url": "https://www.uniprot.org/uniprot/K7EJD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EJD9-1", "url": "https://www.uniprot.org/uniprot/K7EJD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ESF2", "url": "https://www.uniprot.org/uniprot/K7ESF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ESF2-1", "url": "https://www.uniprot.org/uniprot/K7ESF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P13686", "url": "https://www.uniprot.org/uniprot/P13686", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P13686-1", "url": "https://www.uniprot.org/uniprot/P13686-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP", "length": 325, "header": "sp|P13686-1|PPA5_HUMAN Isoform 1 of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=3 CANONICAL=P13686-1" }, "isoforms": [ { "isoform_ac": "A0A3B3IS75-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGD", "length": 71, "header": "tr|A0A3B3IS75-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000649386.1", "url": "https://www.ensembl.org/id/ENST00000649386.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000497140.1", "url": "https://www.ensembl.org/id/ENSP00000497140.1" } ] } }, { "isoform_ac": "A0A8Q3SI79-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQTFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP", "length": 324, "header": "tr|A0A8Q3SI79-1|A0A8Q3SI79_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000695809.1", "url": "https://www.ensembl.org/id/ENST00000695809.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512189.1", "url": "https://www.ensembl.org/id/ENSP00000512189.1" } ] } }, { "isoform_ac": "A0A8Q3WKS0-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQREGDGAPLGAGSIQCLPYPDLVGGSA", "length": 113, "header": "tr|A0A8Q3WKS0-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11576891, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588625.2", "url": "https://www.ensembl.org/id/ENST00000588625.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000512197.1", "url": "https://www.ensembl.org/id/ENSP00000512197.1" } ] } }, { "isoform_ac": "A0A8Q3WKS1-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP", "length": 299, "header": "tr|A0A8Q3WKS1-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000695810.1", "url": "https://www.ensembl.org/id/ENST00000695810.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512190.1", "url": "https://www.ensembl.org/id/ENSP00000512190.1" } ] } }, { "isoform_ac": "A0A8Q3WKT0-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP", "length": 292, "header": "tr|A0A8Q3WKT0-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000695814.1", "url": "https://www.ensembl.org/id/ENST00000695814.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512193.1", "url": "https://www.ensembl.org/id/ENSP00000512193.1" } ] } }, { "isoform_ac": "A0A8Q3WLB6-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQELPQPFLPPALQDPTDQCVCGHFYAGHSDTMWQLR", "length": 122, "header": "tr|A0A8Q3WLB6-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11576484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000695818.1", "url": "https://www.ensembl.org/id/ENST00000695818.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512196.1", "url": "https://www.ensembl.org/id/ENSP00000512196.1" } ] } }, { "isoform_ac": "K7EIP0-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAK", "length": 52, "header": "tr|K7EIP0-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000592828.6", "url": "https://www.ensembl.org/id/ENST00000592828.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000468767.2", "url": "https://www.ensembl.org/id/ENSP00000468767.2" } ] } }, { "isoform_ac": "K7EJD9-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYS", "length": 124, "header": "tr|K7EJD9-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590832.1", "url": "https://www.ensembl.org/id/ENST00000590832.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000465127.1", "url": "https://www.ensembl.org/id/ENSP00000465127.1" } ] } }, { "isoform_ac": "K7ESF2-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFY", "length": 74, "header": "tr|K7ESF2-1|PPA5_HUMAN Computationally mapped isoform of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=1 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000589792.5", "url": "https://www.ensembl.org/id/ENST00000589792.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468685.1", "url": "https://www.ensembl.org/id/ENSP00000468685.1" } ] } }, { "isoform_ac": "P13686-1", "url": "", "sequence": { "sequence": "MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP", "length": 325, "header": "sp|P13686-1|PPA5_HUMAN Isoform 1 of Tartrate-resistant acid phosphatase type 5 OS=Homo sapiens OX=9606 GN=ACP5 PE=1 SV=3 CANONICAL=P13686-1" }, "locus": { "chromosome": "19", "start_pos": 11577317, "end_pos": 11575013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000695791.1", "url": "https://www.ensembl.org/id/ENST00000695791.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512173.1", "url": "https://www.ensembl.org/id/ENSP00000512173.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "1WAR", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1WAR" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 116, "start_aa": "Asn", "end_pos": 116, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn116", "evidence": [ { "id": "P13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13686#ptm_processing" }, { "id": "15993892", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/15993892" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 147, "start_aa": "Asn", "end_pos": 147, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn147", "evidence": [ { "id": "P13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13686#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch.", "journal": "Structure (London, England : 1993)", "date": "2003", "authors": "Karthikeyan S, Zhou Q, Mseeh F, Grishin NV, Osterman AL, Zhang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-196843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-196843" } ], "reference": [ { "type": "PubMed", "id": "12623014", "url": "https://glygen.org/publication/PubMed/12623014" } ] }, { "title": "Heterogeneity of hairy cell tartrate-resistant acid phosphatase.", "journal": "Clin. Biochem.", "date": "1992", "authors": "Janckila A J, Latham M D, Lam K W, Chow K C, Li C Y, Yam L T", "evidence": [ { "database": "UniProtKB", "id": "P13686", "url": "https://www.uniprot.org/uniprot/P13686" } ], "reference": [ { "type": "PubMed", "id": "1477968", "url": "https://glygen.org/publication/PubMed/1477968" } ] }, { "title": "Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop.", "journal": "Journal of molecular biology", "date": "2005", "authors": "Strater N, Jasper B, Scholte M, Krebs B, Duff AP, Langley DB, Han R, Averill BA, Freeman HC, Guss JM", "evidence": [ { "database": "UniProtKB", "id": "P13686", "url": "https://www.uniprot.org/uniprot/P13686#ptm_processing" }, { "database": "UniProtKB", "id": "P13686", "url": "https://www.uniprot.org/uniprot/P13686" } ], "reference": [ { "type": "PubMed", "id": "15993892", "url": "https://glygen.org/publication/PubMed/15993892" } ] }, { "title": "Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Brizio C, Galluccio M, Wait R, Torchetti EM, Bafunno V, Accardi R, Gianazza E, Indiveri C, Barile M", "evidence": [ { "database": "Reactome", "id": "R-HSA-196843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-196843" } ], "reference": [ { "type": "PubMed", "id": "16643857", "url": "https://glygen.org/publication/PubMed/16643857" } ] }, { "title": "Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.", "journal": "American journal of physiology. Cell physiology", "date": "2008", "authors": "Yonezawa A, Masuda S, Katsura T, Inui K", "evidence": [ { "database": "Reactome", "id": "R-HSA-196843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-196843" } ], "reference": [ { "type": "PubMed", "id": "18632736", "url": "https://glygen.org/publication/PubMed/18632736" } ] }, { "title": "Tartrate-resistant acid phosphatase from human osteoclastomas is translated as a single polypeptide.", "journal": "Biochem. 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A report of 4 cases.", "journal": "Archivos argentinos de pediatria", "date": "2024-02-01", "authors": "Dri Jimena, Dos Santos Eugenia, Pereyra Marcela, Guillamondegui Mar\u00eda J, Ballester Celeste, Tolin Ana, Gatica Cristina", "evidence": [ { "database": "RefSeq", "id": "NP_001104504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504" } ], "reference": [ { "type": "PubMed", "id": "37382551", "url": "https://glygen.org/publication/PubMed/37382551" } ] }, { "title": "Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities.", "journal": "European journal of biochemistry", "date": "1994", "authors": "Belli SI, Goding JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-196843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-196843" } ], "reference": [ { "type": "PubMed", "id": "8001561", "url": "https://glygen.org/publication/PubMed/8001561" } ] }, { "title": "Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase.", "journal": "Gene", "date": "1993", "authors": "Cassady A I, King A G, Cross N C, Hume D A", "evidence": [ { "database": "UniProtKB", "id": "P13686", "url": "https://www.uniprot.org/uniprot/P13686" } ], "reference": [ { "type": "PubMed", "id": "8359686", "url": "https://glygen.org/publication/PubMed/8359686" } ] } ], "pathway": [ { "id": "hsa:54", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:54", "resource": "KEGG Pathway" }, { "id": "R-HSA-196843", "name": "Vitamin B2 (riboflavin) metabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-196843", "resource": "Reactome", "description": "Vitamin B2 (riboflavin) metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "P09889-1", "protein_name": "Tartrate-resistant acid phosphatase type 5", "gene_name": "ACP5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"P41498-1", "F1M8U7-1", "A0A0G2JZL2-1", "D4ADM6-1", "M0RCA8-1", "A0A8I6G7Q4-1", "Q6ZNF0-1", "Q9BZG2-1", "P13686-1", "P11117-1", "P05186-1", "P15309-1", "P09923-1", "Q9NPH0-1", "P05187-1", "P10696-1", "P24666-1", "Q8BX37-1", "D3YTS9-1", "Q8BP40-1", "Q9D358-1", "Q05117-1", "P24638-1", "P24822-1", "P24823-1", "Q8CE08-1", "P09242-1", "F8VPQ6-1", "P00635-1", "P11491-1", "P35842-1", "P40347-1", "P24031-1", "P38693-1", "P52290-1", "Q54NC3-1", "Q54P71-1", "Q54P72-1", "Q54SB4-1", "Q54TC4-1", "Q558S4-1", "Q54BS2-1", "Q54Y02-1", "Q55GW2-1", "Q55F77-1", "Q55F12-1", "P82890-1", "P82891-1", "Q24238-1", "X2JB52-1", "Q9W273-1", "Q9W274-1", "Q9VDG4-1", "Q7K3X8-1", "Q9VHD0-1", "Q9W275-1", "B7Z080-1", "Q8I0P9-1", "Q9VW00-1", "Q9VQ86-1" ], "evidence": [ { "id": "15017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15017" } ] }, { "id": "R-HSA-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "equation": "", "summary": "Cytosolic, homodimeric tartrate-resistant acid phosphatase type 5 (TRAP) catalyzes the hydrolysis of flavin mononucleotide (FMN) to yield riboflavin (RIB) and orthophosphate.", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-73524" ], "output_participant_list": [], "enzyme_list": [ "P13686-1" ], "evidence": [ { "id": "R-HSA-196950", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-196950" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-73524", "participant_name": "FMN [cytosol]", "crossref": [ { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" }, { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" }, { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" }, { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" }, { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" }, { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" }, { "id": "C00061", "database": "COMPOUND", "url": "" }, { "id": "58210", "database": "ChEBI", "url": "" }, { "id": "000011524518", "database": "ZINC", "url": "" }, { "id": "000003831425", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JZL2", "gene_name": "Akp3", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A0G2JZL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A0G2JZL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2" } ] } ] }, { "uniprot_ac": "A0A8I6G7Q4", "gene_name": "AABR07036974.1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] } ] }, { "uniprot_ac": "B7Z080", "gene_name": "Dmel\\CG9449", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "B7Z080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7Z080" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "B7Z080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7Z080" } ] } ] }, { "uniprot_ac": "D3YTS9", "gene_name": "Acp4", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "D3YTS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YTS9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "D3YTS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YTS9" } ] } ] }, { "uniprot_ac": "D4ADM6", "gene_name": "Alpp", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "D4ADM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADM6" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "D4ADM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADM6" } ] } ] }, { "uniprot_ac": "F1M8U7", "gene_name": "Alpg", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1M8U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8U7" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F1M8U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8U7" } ] } ] }, { "uniprot_ac": "F8VPQ6", "gene_name": "Alpi", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F8VPQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPQ6" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F8VPQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPQ6" } ] } ] }, { "uniprot_ac": "M0RCA8", "gene_name": "Acp7", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "M0RCA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCA8" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "M0RCA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCA8" } ] } ] }, { "uniprot_ac": "P00635", "gene_name": "PHO5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P00635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00635" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P00635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00635" } ] } ] }, { "uniprot_ac": "P05186", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] } ] }, { "uniprot_ac": "P05187", "gene_name": "ALPP", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P05187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05187" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P05187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05187" } ] } ] }, { "uniprot_ac": "P08289", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] } ] }, { "uniprot_ac": "P09242", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] } ] }, { "uniprot_ac": "P09923", "gene_name": "ALPI", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09923" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09923" } ] } ] }, { "uniprot_ac": "P10696", "gene_name": "ALPG", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P10696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10696" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P10696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10696" } ] } ] }, { "uniprot_ac": "P11117", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11117" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P11117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11117" } ] } ] }, { "uniprot_ac": "P11491", "gene_name": "PHO8", "activity": [ { "ec_number": "3.1.7.6", "activity": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate.", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] }, { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] }, { "ec_number": "3.1.3.54", "activity": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate.", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] } ] }, { "uniprot_ac": "P13686", "gene_name": "ACP5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13686" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13686" } ] } ] }, { "uniprot_ac": "P15309", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] } ] }, { "uniprot_ac": "P15693", "gene_name": "Alpi", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15693" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P15693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15693" } ] } ] }, { "uniprot_ac": "P20611", "gene_name": "Acp2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20611", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20611" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20611", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20611" } ] } ] }, { "uniprot_ac": "P20646", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } 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