{ "uniprot_canonical_ac": "P11831-1", "uniprot_ac": "P11831", "uniprot_id": "SRF_HUMAN", "mass": { "chemical_mass": 51593.0, "monoisotopic_mass": 51593.0 }, "refseq": { "ac": "NP_001278930", "name": "serum response factor isoform 2", "summary": "This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" }, "gene_names": [ { "name": "SRF", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11831", "id": "P11831" }, { "name": "MCM1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930", "id": "NP_001278930" }, { "name": "SRF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930", "id": "NP_001278930" } ], "protein_names": [ { "name": "Serum response factor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11831" }, { "name": "SRF", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11831" }, { "name": "c-fos serum response element-binding transcription factor; minichromosome maintenance 1 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930", "id": "NP_001278930" }, { "name": "serum response factor isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930", "id": "NP_001278930" } ], "function": [ { "annotation": "Cellular myofibromas with SRF fusions: clinicopathological and molecular study of 3 cases of a rare entity and a potential mimic of sarcoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" }, { "database": "PubMed", "id": "37245628", "url": "https://glygen.org/publication/PubMed/37245628" } ] }, { "annotation": "Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" }, { "database": "PubMed", "id": "37558923", "url": "https://glygen.org/publication/PubMed/37558923" } ] }, { "annotation": "Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes.", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" }, { "database": "PubMed", "id": "34417138", "url": "https://glygen.org/publication/PubMed/34417138" } ] }, { "annotation": "IGF2BP2, an RNA-binding protein regulates cell proliferation and osteogenic differentiation by stabilizing SRF mRNA.", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" }, { "database": "PubMed", "id": "36436184", "url": "https://glygen.org/publication/PubMed/36436184" } ] }, { "annotation": "SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831#function" }, { "database": "UniProtKB", "id": "Q9JM73", "url": "https://www.uniprot.org/uniprot/Q9JM73#function" } ] }, { "annotation": "SRF/MRTF-A and liver cirrhosis: Pathologic associations. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" }, { "database": "PubMed", "id": "36601855", "url": "https://glygen.org/publication/PubMed/36601855" } ] }, { "annotation": "This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs750655050", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750655050" }, { "id": "rs750655050", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750655050" }, { "id": "rs750655050", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs750655050#frequency_tab" }, { "id": "rs750655050", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs750655050" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 309, "end_pos": 309, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SVS->NVS); o-glyco-site-loss (S->N).", "chr_id": "6", "chr_pos": "43175851", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S309", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P11831", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11831" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 245, "end_pos": 245, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DLT->NLT).", "chr_id": "6", "chr_pos": "43174066", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D245", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs754832739", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754832739" }, { "id": "rs754832739", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754832739" }, { "id": "rs754832739", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs754832739" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 276, "end_pos": 276, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TST->NST).", "chr_id": "6", "chr_pos": "43175752", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T276", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs949828524", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs949828524" }, { "id": "rs949828524", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs949828524" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 313, "end_pos": 313, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->N).", "chr_id": "6", "chr_pos": "43175863", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S313", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P11831", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11831" }, { "id": "rs778816086", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778816086" }, { "id": "rs778816086", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778816086" }, { "id": "rs778816086", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778816086" }, { "id": "rs778816086", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778816086" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 324, "end_pos": 324, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KST->NST).", "chr_id": "6", "chr_pos": "43175897", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "K324", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "P11831", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11831" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 36, "end_pos": 36, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "A", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (T->A).", "chr_id": "6", "chr_pos": "43171762", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "T36", "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1184049027", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1184049027" }, { "id": "rs1184049027", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1184049027" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 375, "end_pos": 375, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SST->NST).", "chr_id": "6", "chr_pos": "43176629", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S375", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs748750154", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748750154" }, { "id": "rs748750154", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748750154" }, { "id": "rs748750154", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs748750154" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 385, "end_pos": 385, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).", "chr_id": "6", "chr_pos": "43176660", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S385", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs146671770", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146671770" }, { "id": "rs146671770", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146671770" }, { "id": "rs146671770", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146671770" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 427, "end_pos": 427, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SLT->NLT).", "chr_id": "6", "chr_pos": "43178411", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S427", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1403902458", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1403902458" }, { "id": "rs1403902458", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1403902458#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 42, "end_pos": 42, "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGG->NGS).", "chr_id": "6", "chr_pos": "43171780", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G42", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P11831", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11831" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 503, "end_pos": 503, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "H", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (HST->NST).", "chr_id": "6", "chr_pos": "43179170", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "H503", "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "77.77", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "76.71", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "75.31", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "95.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "85.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "82.77", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "86.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "78.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "79.86", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "89.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11831" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "common_name": "Human" } ], "gene": [ { "name": "SRF", "url": "https://www.uniprot.org/uniprot/P11831", "locus": { "chromosome": "6", "start_pos": 43181506, "end_pos": 43171269, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000112658", "url": "https://www.ensembl.org/id/ENSG00000112658" } ] } } ], "crossref": [ { "id": "ENSG00000112658", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000112658", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P11831", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11831", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd00266", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00266", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4523184", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4523184", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "SRF", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SRF", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "6722", "url": "https://www.ncbi.nlm.nih.gov/gene/6722", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "561", "url": "https://glyconnect.expasy.org/browser/proteins/561", "database": "GlyConnect", "categories": [ "Glycoproteomics", "Glycan" ] }, { "id": "11291", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11291", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P11831", "url": "https://www.ebi.ac.uk/intact/interactors/id:P11831*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:6722", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6722", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "600589", "url": "http://www.omim.org/entry/600589", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P11831", "url": "https://www.nextprot.org/entry/NX_P11831", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P11831", "url": "https://oglcnac.org/atlas/detail/P11831", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "DTSHNAK", "url": "https://omabrowser.org/oma/group/DTSHNAK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "832279at2759", "url": "http://www.orthodb.org/?query=832279at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48019:SF168", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48019:SF168", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1HBX", "url": "https://www.rcsb.org/structure/1HBX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1K6O", "url": "https://www.rcsb.org/structure/1K6O", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1SRS", "url": "https://www.rcsb.org/structure/1SRS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00319", "url": "http://pfam.xfam.org/family/PF00319", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P11831", "url": "https://pharos.nih.gov/targets/P11831", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P11831", "url": "http://purl.obolibrary.org/obo/PR_P11831", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9768777", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9768777", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11831-1", "url": "https://www.uniprot.org/uniprot/P11831-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAAAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAHSTKSE", "length": 508, "header": "sp|P11831-1|SRF_HUMAN Isoform 1 of Serum response factor OS=Homo sapiens OX=9606 GN=SRF PE=1 SV=1 CANONICAL=P11831-1" }, "isoforms": [ { "isoform_ac": "P11831-1", "url": "", "sequence": { "sequence": "MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAAAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAHSTKSE", "length": 508, "header": "sp|P11831-1|SRF_HUMAN Isoform 1 of Serum response factor OS=Homo sapiens OX=9606 GN=SRF PE=1 SV=1 CANONICAL=P11831-1" }, "locus": { "chromosome": "6", "start_pos": 43179187, "end_pos": 43171657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000265354.6", "url": "https://www.ensembl.org/id/ENST00000265354.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000265354.4", "url": "https://www.ensembl.org/id/ENSP00000265354.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 277, "start_aa": "Ser", "end_pos": 277, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser277", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" }, { "id": "561", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/561" }, { "id": "1687959", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1687959" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 277, "start_aa": "Ser", "end_pos": 277, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser277", "evidence": [ { "id": "P11831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11831#ptm_processing" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 288, "start_aa": "Thr", "end_pos": 288, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr288", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 307, "start_aa": "Ser", "end_pos": 307, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser307", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 307, "start_aa": "Ser", "end_pos": 307, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser307", "evidence": [ { "id": "P11831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11831#ptm_processing" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 309, "start_aa": "Ser", "end_pos": 309, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser309", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 309, "start_aa": "Ser", "end_pos": 309, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser309", "evidence": [ { "id": "P11831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11831#ptm_processing" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 311, "start_aa": "Ser", "end_pos": 311, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser311", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 313, "start_aa": "Ser", "end_pos": 313, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser313", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 316, "start_aa": "Ser", "end_pos": 316, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser316", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" }, { "id": "561", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/561" }, { "id": "1687959", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1687959" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 316, "start_aa": "Ser", "end_pos": 316, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser316", "evidence": [ { "id": "P11831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11831#ptm_processing" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 36, "start_aa": "Thr", "end_pos": 36, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr36", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 383, "start_aa": "Ser", "end_pos": 383, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser383", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 383, "start_aa": "Ser", "end_pos": 383, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser383", "evidence": [ { "id": "P11831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11831#ptm_processing" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 384, "start_aa": "Ser", "end_pos": 384, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser384", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 385, "start_aa": "Ser", "end_pos": 385, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser385", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 401, "start_aa": "Thr", "end_pos": 401, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr401", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 460, "start_aa": "Thr", "end_pos": 460, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr460", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 462, "start_aa": "Ser", "end_pos": 462, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser462", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 463, "start_aa": "Ser", "end_pos": 463, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser463", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 465, "start_aa": "Thr", "end_pos": 465, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr465", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 471, "start_aa": "Ser", "end_pos": 471, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser471", "evidence": [ { "id": "P11831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "12684542", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12684542" }, { "id": "1512232", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1512232" }, { "id": "P11831", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11831" } ] } ], "phosphorylation": [ { "start_pos": 103, "end_pos": 103, "kinase_uniprot_canonical_ac": "P49137-1", "kinase_gene_name": "MAPKAPK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "10318869", "url": "https://glygen.org/publication/PubMed/10318869" }, { "database": "PubMed", "id": "10753652", "url": "https://glygen.org/publication/PubMed/10753652" }, { "database": "PubMed", "id": "12171911", "url": "https://glygen.org/publication/PubMed/12171911" }, { "database": "PubMed", "id": "8413226", "url": "https://glygen.org/publication/PubMed/8413226" } ], "site_lbl": "Ser103" }, { "start_pos": 103, "end_pos": 103, "kinase_uniprot_canonical_ac": "Q15418-1", "kinase_gene_name": "RPS6KA1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "10318869", "url": "https://glygen.org/publication/PubMed/10318869" }, { "database": "PubMed", "id": "10753652", "url": "https://glygen.org/publication/PubMed/10753652" }, { "database": "PubMed", "id": "8413226", "url": "https://glygen.org/publication/PubMed/8413226" } ], "site_lbl": "Ser103" }, { "start_pos": 103, "end_pos": 103, "kinase_uniprot_canonical_ac": "Q9UQM7-1", "kinase_gene_name": "CAMK2A", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "10318869", "url": "https://glygen.org/publication/PubMed/10318869" }, { "database": "PubMed", "id": "10753652", "url": "https://glygen.org/publication/PubMed/10753652" }, { "database": "PubMed", "id": "8413226", "url": "https://glygen.org/publication/PubMed/8413226" } ], "site_lbl": "Ser103" }, { "start_pos": 103, "end_pos": 103, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "8413226", "url": "https://glygen.org/publication/PubMed/8413226" }, { "database": "PubMed", "id": "10318869", "url": "https://glygen.org/publication/PubMed/10318869" }, { "database": "PubMed", "id": "11859076", "url": "https://glygen.org/publication/PubMed/11859076" }, { "database": "PubMed", "id": "21074607", "url": "https://glygen.org/publication/PubMed/21074607" }, { "database": "PubMed", "id": "32933333", "url": "https://glygen.org/publication/PubMed/32933333" }, { "database": "PubMed", "id": "7929249", "url": "https://glygen.org/publication/PubMed/7929249" } ], "site_lbl": "Ser103" }, { "start_pos": 159, "end_pos": 159, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "12809504", "url": "https://glygen.org/publication/PubMed/12809504" }, { "database": "PubMed", "id": "19778940", "url": "https://glygen.org/publication/PubMed/19778940" } ], "site_lbl": "Thr159" }, { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "Q05655-1", "kinase_gene_name": "PRKCD", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "15282327", "url": "https://glygen.org/publication/PubMed/15282327" } ], "site_lbl": "Thr160" }, { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "Q9UQM7-1", "kinase_gene_name": "CAMK2A", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "10753652", "url": "https://glygen.org/publication/PubMed/10753652" } ], "site_lbl": "Thr160" }, { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "10753652", "url": "https://glygen.org/publication/PubMed/10753652" }, { "database": "PubMed", "id": "15282327", "url": "https://glygen.org/publication/PubMed/15282327" } ], "site_lbl": "Thr160" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "PubMed", "id": "34381779", "url": "" } ], "site_lbl": "Ser224" }, { "start_pos": 228, "end_pos": 228, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" } ], "site_lbl": "Ser228" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "8375385", "url": "https://glygen.org/publication/PubMed/8375385" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "site_lbl": "Ser253" }, { "start_pos": 435, "end_pos": 435, "kinase_uniprot_canonical_ac": "P78527-1", "kinase_gene_name": "PRKDC", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "8407951", "url": "https://glygen.org/publication/PubMed/8407951" } ], "site_lbl": "Ser435" }, { "start_pos": 435, "end_pos": 435, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by dsDNA kinase", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "8407951", "url": "https://glygen.org/publication/PubMed/8407951" } ], "site_lbl": "Ser435" }, { "start_pos": 446, "end_pos": 446, "kinase_uniprot_canonical_ac": "P78527-1", "kinase_gene_name": "PRKDC", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "8407951", "url": "https://glygen.org/publication/PubMed/8407951" } ], "site_lbl": "Ser446" }, { "start_pos": 446, "end_pos": 446, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by dsDNA kinase", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "8407951", "url": "https://glygen.org/publication/PubMed/8407951" } ], "site_lbl": "Ser446" }, { "start_pos": 71, "end_pos": 71, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "32387766", "url": "" } ], "site_lbl": "Thr71" }, { "start_pos": 76, "end_pos": 76, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Tyr76" }, { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "PubMed", "id": "2046671", "url": "https://glygen.org/publication/PubMed/2046671" } ], "site_lbl": "Ser77" }, { "start_pos": 79, "end_pos": 79, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "PubMed", "id": "2046671", "url": "https://glygen.org/publication/PubMed/2046671" } ], "site_lbl": "Ser79" }, { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "P68400-1", "kinase_gene_name": "CSNK2A1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "1740119", "url": "https://glygen.org/publication/PubMed/1740119" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "2046671", "url": "https://glygen.org/publication/PubMed/2046671" } ], "site_lbl": "Ser83" }, { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "2046671", "url": "https://glygen.org/publication/PubMed/2046671" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" } ], "site_lbl": "Ser83" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "P49137-1", "kinase_gene_name": "MAPKAPK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "10318869", "url": "https://glygen.org/publication/PubMed/10318869" } ], "site_lbl": "Ser85" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "2046671", "url": "https://glygen.org/publication/PubMed/2046671" }, { "database": "phospho.ELM", "id": "P11831", "url": "http://phospho.elm.eu.org/byAccession/P11831.html" }, { "database": "PubMed", "id": "11859076", "url": "https://glygen.org/publication/PubMed/11859076" } ], "site_lbl": "Ser85" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "DREAM is a Ca2+-regulated transcriptional repressor.", "journal": "Nature", "date": "1999", "authors": "Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9768777", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9768777" } ], "reference": [ { "type": "PubMed", "id": "10078534", "url": "https://glygen.org/publication/PubMed/10078534" } ] }, { "title": "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.", "journal": "Cell", "date": "1999", "authors": "Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "10102273", "url": "https://glygen.org/publication/PubMed/10102273" } ] }, { "title": "The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience.", "journal": "Trends in neurosciences", "date": "1999", "authors": "O'Donovan KJ, Tourtellotte WG, Millbrandt J, Baraban JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10203854", "url": "https://glygen.org/publication/PubMed/10203854" } ] }, { "title": "Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.", "journal": "The EMBO journal", "date": "1999", "authors": "Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "10228164", "url": "https://glygen.org/publication/PubMed/10228164" } ] }, { "title": "MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "10318869", "url": "https://glygen.org/publication/PubMed/10318869" } ] }, { "title": "Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase.", "journal": "Neuroscience letters", "date": "1999", "authors": "Nagasaki K, Sasaki K, Maass N, Tsukada T, Hanzawa H, Yamaguchi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10381005", "url": "https://glygen.org/publication/PubMed/10381005" } ] }, { "title": "Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Samudio I, Kladde MP, Vyhlidal C, Safe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "10542244", "url": "https://glygen.org/publication/PubMed/10542244" } ] }, { "title": "X-ray structure determination of human profilin II: A comparative structural analysis of human profilins.", "journal": "Journal of molecular biology", "date": "1999", "authors": "Nodelman IM, Bowman GD, Lindberg U, Schutt CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "10600384", "url": "https://glygen.org/publication/PubMed/10600384" } ] }, { "title": "Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Massari ME, Murre C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10611221", "url": "https://glygen.org/publication/PubMed/10611221" } ] }, { "title": "Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Zhu J, Tseng YH, Kantor JD, Rhodes CJ, Zetter BR, Moyers JS, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10611312", "url": "https://glygen.org/publication/PubMed/10611312" } ] }, { "title": "Reciprocal Id expression and myelin gene regulation in Schwann cells.", "journal": "Molecular and cellular neurosciences", "date": "1999", "authors": "Thatikunta P, Qin W, Christy BA, Tennekoon GI, Rutkowski JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10656257", "url": "https://glygen.org/publication/PubMed/10656257" } ] }, { "title": "Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.", "journal": "Molecular cell", "date": "2000", "authors": "Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "10678165", "url": "https://glygen.org/publication/PubMed/10678165" } ] }, { "title": "A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Sevetson BR, Svaren J, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10734128", "url": "https://glygen.org/publication/PubMed/10734128" } ] }, { "title": "Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Fluck M, Booth FW, Waxham MN", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "10753652", "url": "https://glygen.org/publication/PubMed/10753652" } ] }, { "title": "Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element.", "journal": "DNA sequence : the journal of DNA sequencing and mapping", "date": "2000", "authors": "Schwachtgen JL, Campbell CJ, Braddock M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10826704", "url": "https://glygen.org/publication/PubMed/10826704" } ] }, { "title": "Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Ishida N, Kitagawa M, Hatakeyama S, Nakayama K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "10831586", "url": "https://glygen.org/publication/PubMed/10831586" } ] }, { "title": "CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.", "journal": "Annual review of biochemistry", "date": "1999", "authors": "Shaywitz AJ, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10872467", "url": "https://glygen.org/publication/PubMed/10872467" } ] }, { "title": "VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance.", "journal": "Frontiers in neuroendocrinology", "date": "2000", "authors": "Salton SR, Ferri GL, Hahm S, Snyder SE, Wilson AJ, Possenti R, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10882540", "url": "https://glygen.org/publication/PubMed/10882540" } ] }, { "title": "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Yayoshi-Yamamoto S, Taniuchi I, Watanabe T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "10958683", "url": "https://glygen.org/publication/PubMed/10958683" } ] }, { "title": "EGR1 target genes in prostate carcinoma cells identified by microarray analysis.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Svaren J, Ehrig T, Abdulkadir SA, Ehrengruber MU, Watson MA, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "10984481", "url": "https://glygen.org/publication/PubMed/10984481" } ] }, { "title": "The human transcriptional repressor protein NAB1: expression and biological activity.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Thiel G, Kaufmann K, Magin A, Lietz M, Bach K, Cramer M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11018254", "url": "https://glygen.org/publication/PubMed/11018254" } ] }, { "title": "Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Nogueira MM, Mitjavila-Garcia MT, Le Pesteur F, Filippi MD, Vainchenker W, Dubart Kupperschmitt A, Sainteny F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11027551", "url": "https://glygen.org/publication/PubMed/11027551" } ] }, { "title": "Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Duan R, Xie W, Burghardt RC, Safe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11145955", "url": "https://glygen.org/publication/PubMed/11145955" } ] }, { "title": "Reduction in cyclin D1/Cdk4/retinoblastoma protein signaling by CRE-decoy oligonucleotide.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Park YG, Park S, Lim SO, Lee MS, Ryu CK, Kim I, Cho-Chung YS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11243864", "url": "https://glygen.org/publication/PubMed/11243864" } ] }, { "title": "Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.", "journal": "Cancer research", "date": "2001", "authors": "Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, Moyers JS, Watson PH, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11280768", "url": "https://glygen.org/publication/PubMed/11280768" } ] }, { "title": "ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.", "journal": "Nature cell biology", "date": "2001", "authors": "Harada T, Morooka T, Ogawa S, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11331872", "url": "https://glygen.org/publication/PubMed/11331872" } ] }, { "title": "Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation.", "journal": "Neuron", "date": "2001", "authors": "Steward O, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11343657", "url": "https://glygen.org/publication/PubMed/11343657" } ] }, { "title": "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma.", "journal": "Human pathology", "date": "2001", "authors": "Abdulkadir SA, Carbone JM, Naughton CK, Humphrey PA, Catalona WJ, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11567222", "url": "https://glygen.org/publication/PubMed/11567222" } ] }, { "title": "PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells.", "journal": "The EMBO journal", "date": "2001", "authors": "Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, Fiorentino R, Varricchio L, Barone MV, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11689445", "url": "https://glygen.org/publication/PubMed/11689445" } ] }, { "title": "p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.", "journal": "The EMBO journal", "date": "2001", "authors": "Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11726503", "url": "https://glygen.org/publication/PubMed/11726503" } ] }, { "title": "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction.", "journal": "FEBS letters", "date": "2002", "authors": "Mandolesi G, Gargano S, Pennuto M, Illi B, Molfetta R, Soucek L, Mosca L, Levi A, Jucker R, Nasi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11755530", "url": "https://glygen.org/publication/PubMed/11755530" } ] }, { "title": "The regulation and function of the Id proteins in lymphocyte development.", "journal": "Oncogene", "date": "2001", "authors": "Rivera R, Murre C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11840323", "url": "https://glygen.org/publication/PubMed/11840323" } ] }, { "title": "Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Charvet C, Auberger P, Tartare-Deckert S, Bernard A, Deckert M", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "11859076", "url": "https://glygen.org/publication/PubMed/11859076" } ] }, { "title": "Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2002", "authors": "Richards JS, Sharma SC, Falender AE, Lo YH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11875118", "url": "https://glygen.org/publication/PubMed/11875118" } ] }, { "title": "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11889117", "url": "https://glygen.org/publication/PubMed/11889117" } ] }, { "title": "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "11956230", "url": "https://glygen.org/publication/PubMed/11956230" } ] }, { "title": "AP-1 as a regulator of cell life and death.", "journal": "Nature cell biology", "date": "2002", "authors": "Shaulian E, Karin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "11988758", "url": "https://glygen.org/publication/PubMed/11988758" } ] }, { "title": "Estrogen alters thresholds for B cell apoptosis and activation.", "journal": "The Journal of clinical investigation", "date": "2002", "authors": "Grimaldi CM, Cleary J, Dagtas AS, Moussai D, Diamond B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "12070310", "url": "https://glygen.org/publication/PubMed/12070310" } ] }, { "title": "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.", "journal": "The EMBO journal", "date": "2002", "authors": "Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, Nabel EG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "12093740", "url": "https://glygen.org/publication/PubMed/12093740" } ] }, { "title": "Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Meng W, Swenson LL, Fitzgibbon MJ, Hayakawa K, Ter Haar E, Behrens AE, Fulghum JR, Lippke JA", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "12171911", "url": "https://glygen.org/publication/PubMed/12171911" } ] }, { "title": "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.", "journal": "Science (New York, N.Y.)", "date": "2002", "authors": "Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "12399542", "url": "https://glygen.org/publication/PubMed/12399542" } ] }, { "title": "The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization.", "journal": "Molecular biology of the cell", "date": "2002", "authors": "Copeland JW, Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "12429848", "url": "https://glygen.org/publication/PubMed/12429848" } ] }, { "title": "Synthesis of serotonin by a second tryptophan hydroxylase isoform.", "journal": "Science (New York, N.Y.)", "date": "2003", "authors": "Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "12511643", "url": "https://glygen.org/publication/PubMed/12511643" } ] }, { "title": "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.", "journal": "Nature cell biology", "date": "2003", "authors": "Gasman S, Kalaidzidis Y, Zerial M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "12577064", "url": "https://glygen.org/publication/PubMed/12577064" } ] }, { "title": "Identification of novel sites of O-N-acetylglucosamine modification of serum response factor using quadrupole time-of-flight mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2003", "authors": "Chalkley RJ, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "database": "O-GlcNAc Atlas", "id": "P11831", "url": "https://oglcnac.org/atlas/detail/P11831" } ], "reference": [ { "type": "PubMed", "id": "12684542", "url": "https://glygen.org/publication/PubMed/12684542" } ] }, { "title": "Actin dynamics control SRF activity by regulation of its coactivator MAL.", "journal": "Cell", "date": "2003", "authors": "Miralles F, Posern G, Zaromytidou AI, Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "12732141", "url": "https://glygen.org/publication/PubMed/12732141" } ] }, { "title": "A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.", "journal": "The EMBO journal", "date": "2003", "authors": "Grosse R, Copeland JW, Newsome TP, Way M, Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "12805219", "url": "https://glygen.org/publication/PubMed/12805219" } ] }, { "title": "Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription.", "journal": "Biochemistry", "date": "2003", "authors": "Iyer D, Belaguli N, Fluck M, Rowan BG, Wei L, Weigel NL, Booth FW, Epstein HF, Schwartz RJ, Balasubramanyam A", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "12809504", "url": "https://glygen.org/publication/PubMed/12809504" } ] }, { "title": "The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.", "journal": "Cell proliferation", "date": "2003", "authors": "Vermeulen K, Van Bockstaele DR, Berneman ZN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "12814430", "url": "https://glygen.org/publication/PubMed/12814430" } ] }, { "title": "Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Foster JS, Fernando RI, Ishida N, Nakayama KI, Wimalasena J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "12904306", "url": "https://glygen.org/publication/PubMed/12904306" } ] }, { "title": "NGF induces the expression of the VGF gene through a cAMP response element.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "1992", "authors": "Hawley RJ, Scheibe RJ, Wagner JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1377233", "url": "https://glygen.org/publication/PubMed/1377233" } ] }, { "title": "Local regulation of fat metabolism in peripheral nerves.", "journal": "Genes & development", "date": "2003", "authors": "Verheijen MH, Chrast R, Burrola P, Lemke G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "14522948", "url": "https://glygen.org/publication/PubMed/14522948" } ] }, { "title": "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Selvaraj A, Prywes R", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "14565952", "url": "https://glygen.org/publication/PubMed/14565952" } ] }, { "title": "Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, Dandolo L, Hamon M, Mallet J, Vodjdani G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "14597720", "url": "https://glygen.org/publication/PubMed/14597720" } ] }, { "title": "17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression.", "journal": "The Journal of investigative dermatology", "date": "2003", "authors": "Kanda N, Watanabe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "14675202", "url": "https://glygen.org/publication/PubMed/14675202" } ] }, { "title": "Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC).", "journal": "Brain research. Molecular brain research", "date": "2004", "authors": "Teber I, Kohling R, Speckmann EJ, Barnekow A, Kremerskothen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "14969744", "url": "https://glygen.org/publication/PubMed/14969744" } ] }, { "title": "Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture.", "journal": "Cell", "date": "2004", "authors": "Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "15006353", "url": "https://glygen.org/publication/PubMed/15006353" } ] }, { "title": "Cdc42 and mDia3 regulate microtubule attachment to kinetochores.", "journal": "Nature", "date": "2004", "authors": "Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "15085137", "url": "https://glygen.org/publication/PubMed/15085137" } ] }, { "title": "The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, Pezzi V, Montanaro D, Musti AM, Picard D, Ando S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "15090535", "url": "https://glygen.org/publication/PubMed/15090535" } ] }, { "title": "TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs).", "journal": "Journal of cellular biochemistry", "date": "2004-05-01", "authors": "Sun Guifeng, Lewis Lisa E, Huang Xu, Nguyen Quang, Price Christopher, Huang Taosheng", "evidence": [ { "database": "Reactome", "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709" } ], "reference": [ { "type": "PubMed", "id": "15095414", "url": "https://glygen.org/publication/PubMed/15095414" } ] }, { "title": "Rho kinase regulates schwann cell myelination and formation of associated axonal domains.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2004", "authors": "Melendez-Vasquez CV, Einheber S, Salzer JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15102911", "url": "https://glygen.org/publication/PubMed/15102911" } ] }, { "title": "Localization of O-GlcNAc modification on the serum response transcription factor.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Reason AJ, Morris HR, Panico M, Marais R, Treisman RH, Haltiwanger RS, Hart GW, Kelly WG, Dell A", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831#ptm_processing" }, { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "O-GlcNAc Database", "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "database": "O-GlcNAc Atlas", "id": "P11831", "url": "https://oglcnac.org/atlas/detail/P11831" } ], "reference": [ { "type": "PubMed", "id": "1512232", "url": "https://glygen.org/publication/PubMed/1512232" } ] }, { "title": "Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Yamauchi J, Chan JR, Shooter EM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15161978", "url": "https://glygen.org/publication/PubMed/15161978" } ] }, { "title": "17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression.", "journal": "The Journal of investigative dermatology", "date": "2004", "authors": "Kanda N, Watanabe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "15245432", "url": "https://glygen.org/publication/PubMed/15245432" } ] }, { "title": "Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Wheaton K, Riabowol K", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "15282327", "url": "https://glygen.org/publication/PubMed/15282327" } ] }, { "title": "Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Castoria G, Migliaccio A, Di Domenico M, Lombardi M, de Falco A, Varricchio L, Bilancio A, Barone MV, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "15314172", "url": "https://glygen.org/publication/PubMed/15314172" } ] }, { "title": "Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.", "journal": "Journal of cellular biochemistry", "date": "2004", "authors": "Chen CC, Lee WR, Safe S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15449318", "url": "https://glygen.org/publication/PubMed/15449318" } ] }, { "title": "Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.", "journal": "The EMBO journal", "date": "1992", "authors": "Janknecht R, Hipskind RA, Houthaeve T, Nordheim A, Stunnenberg HG", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" } ] }, { "title": "Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis.", "journal": "Cell", "date": "2004", "authors": "Romero S, Le Clainche C, Didry D, Egile C, Pantaloni D, Carlier MF", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "15507212", "url": "https://glygen.org/publication/PubMed/15507212" } ] }, { "title": "Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LA, O'donnell A, Hayes A, Sharrocks AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15542842", "url": "https://glygen.org/publication/PubMed/15542842" } ] }, { "title": "AP-1 subunits: quarrel and harmony among siblings.", "journal": "Journal of cell science", "date": "2004", "authors": "Hess J, Angel P, Schorpp-Kistner M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "15564374", "url": "https://glygen.org/publication/PubMed/15564374" } ] }, { "title": "Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.", "journal": "Cell", "date": "2004", "authors": "Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, Goodman RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15620361", "url": "https://glygen.org/publication/PubMed/15620361" } ] }, { "title": "Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Possenti R, Di Rocco G, Nasi S, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1570299", "url": "https://glygen.org/publication/PubMed/1570299" } ] }, { "title": "Integration of the extranuclear and nuclear actions of estrogen.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2005", "authors": "Levin ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "15705661", "url": "https://glygen.org/publication/PubMed/15705661" } ] }, { "title": "Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.", "journal": "FEBS letters", "date": "2005", "authors": "David S, Kalb RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15733869", "url": "https://glygen.org/publication/PubMed/15733869" } ] }, { "title": "Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination.", "journal": "Journal of neurochemistry", "date": "2005", "authors": "Leblanc SE, Srinivasan R, Ferri C, Mager GM, Gillian-Daniel AL, Wrabetz L, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15836632", "url": "https://glygen.org/publication/PubMed/15836632" } ] }, { "title": "Structural and mechanistic insights into the interaction between Rho and mammalian Dia.", "journal": "Nature", "date": "2005", "authors": "Rose R, Weyand M, Lammers M, Ishizaki T, Ahmadian MR, Wittinghofer A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "15864301", "url": "https://glygen.org/publication/PubMed/15864301" } ] }, { "title": "Structural basis of Rho GTPase-mediated activation of the formin mDia1.", "journal": "Molecular cell", "date": "2005", "authors": "Otomo T, Otomo C, Tomchick DR, Machius M, Rosen MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "15866170", "url": "https://glygen.org/publication/PubMed/15866170" } ] }, { "title": "SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability.", "journal": "Nature neuroscience", "date": "2005", "authors": "Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schutz G, Linden DJ, Ginty DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "15880109", "url": "https://glygen.org/publication/PubMed/15880109" } ] }, { "title": "Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling.", "journal": "Oncogene", "date": "2005", "authors": "Felty Q, Singh KP, Roy D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "15897899", "url": "https://glygen.org/publication/PubMed/15897899" } ] }, { "title": "RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1.", "journal": "Journal of cell science", "date": "2005", "authors": "Fernandez-Borja M, Janssen L, Verwoerd D, Hordijk P, Neefjes J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "15944396", "url": "https://glygen.org/publication/PubMed/15944396" } ] }, { "title": "Id family of helix-loop-helix proteins in cancer.", "journal": "Nature reviews. Cancer", "date": "2005", "authors": "Perk J, Iavarone A, Benezra R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16034366", "url": "https://glygen.org/publication/PubMed/16034366" } ] }, { "title": "Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.", "journal": "Dev. Cell", "date": "2005", "authors": "Liu Zhi-Ping, Wang Zhigao, Yanagisawa Hiromi, Olson Eric N", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "16054032", "url": "https://glygen.org/publication/PubMed/16054032" } ] }, { "title": "Nab proteins are essential for peripheral nervous system myelination.", "journal": "Nature neuroscience", "date": "2005", "authors": "Le N, Nagarajan R, Wang JY, Svaren J, LaPash C, Araki T, Schmidt RE, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16136673", "url": "https://glygen.org/publication/PubMed/16136673" } ] }, { "title": "BMP enhances transcriptional responses to NGF during PC12 cell differentiation.", "journal": "Neurochemical research", "date": "2005", "authors": "Lonn P, Zaia K, Israelsson C, Althini S, Usoskin D, Kylberg A, Ebendal T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16187211", "url": "https://glygen.org/publication/PubMed/16187211" } ] }, { "title": "The Fos family of transcription factors and their role in tumourigenesis.", "journal": "European journal of cancer (Oxford, England : 1990)", "date": "2005", "authors": "Milde-Langosch K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "16199154", "url": "https://glygen.org/publication/PubMed/16199154" } ] }, { "title": "A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16221685", "url": "https://glygen.org/publication/PubMed/16221685" } ] }, { "title": "The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2006", "authors": "Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Ando S, Maggiolini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "16239258", "url": "https://glygen.org/publication/PubMed/16239258" } ] }, { "title": "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Kumbrink J, Gerlinger M, Johnson JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16260776", "url": "https://glygen.org/publication/PubMed/16260776" } ] }, { "title": "The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Li L, Carter J, Gao X, Whitehead J, Tourtellotte WG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16287845", "url": "https://glygen.org/publication/PubMed/16287845" } ] }, { "title": "The regulation of mDia1 by autoinhibition and its release by Rho*GTP.", "journal": "The EMBO journal", "date": "2005", "authors": "Lammers M, Rose R, Scrima A, Wittinghofer A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "16292343", "url": "https://glygen.org/publication/PubMed/16292343" } ] }, { "title": "Immediate-early gene-encoded protein Arc is associated with synaptic delivery of GluR4-containing AMPA receptors during in vitro classical conditioning.", "journal": "Journal of neurophysiology", "date": "2006", "authors": "Mokin M, Lindahl JS, Keifer J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16339507", "url": "https://glygen.org/publication/PubMed/16339507" } ] }, { "title": "Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2006", "authors": "Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16407550", "url": "https://glygen.org/publication/PubMed/16407550" } ] }, { "title": "Control of the assembly of ATP- and ADP-actin by formins and profilin.", "journal": "Cell", "date": "2006", "authors": "Kovar DR, Harris ES, Mahaffy R, Higgs HN, Pollard TD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "16439214", "url": "https://glygen.org/publication/PubMed/16439214" } ] }, { "title": "Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16484497", "url": "https://glygen.org/publication/PubMed/16484497" } ] }, { "title": "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Srinivasan R, Mager GM, Ward RM, Mayer J, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16574654", "url": "https://glygen.org/publication/PubMed/16574654" } ] }, { "title": "The human CENP-A centromeric nucleosome-associated complex.", "journal": "Nature cell biology", "date": "2006", "authors": "Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "16622419", "url": "https://glygen.org/publication/PubMed/16622419" } ] }, { "title": "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.", "journal": "Nature cell biology", "date": "2006", "authors": "Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "16622420", "url": "https://glygen.org/publication/PubMed/16622420" } ] }, { "title": "AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc.", "journal": "Nature neuroscience", "date": "2006", "authors": "Rao VR, Pintchovski SA, Chin J, Peebles CL, Mitra S, Finkbeiner S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "16732277", "url": "https://glygen.org/publication/PubMed/16732277" } ] }, { "title": "17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.", "journal": "Molecular pharmacology", "date": "2006", "authors": "Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, Ando S, Maggiolini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "16835357", "url": "https://glygen.org/publication/PubMed/16835357" } ] }, { "title": "11th International Symposium on Glycoconjugates. Toronto, Canada, June 30-July 5, 1991. Abstracts.", "journal": "Glycoconjugate journal", "date": "1991", "authors": "author information missing", "evidence": [ { "database": "GlyConnect", "id": "561", "url": "https://glyconnect.expasy.org/browser/proteins/561" } ], "reference": [ { "type": "PubMed", "id": "1687959", "url": "https://glygen.org/publication/PubMed/1687959" } ] }, { "title": "Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Seth A, Otomo C, Rosen MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "16943183", "url": "https://glygen.org/publication/PubMed/16943183" } ] }, { "title": "Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Liu ST, Rattner JB, Jablonski SA, Yen TJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "17030981", "url": "https://glygen.org/publication/PubMed/17030981" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.", "journal": "Neuron", "date": "2006", "authors": "Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Grant SG, Bliss TV, Wolfer DP, Kuhl D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17088210", "url": "https://glygen.org/publication/PubMed/17088210" } ] }, { "title": "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.", "journal": "Neuron", "date": "2006", "authors": "Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17088211", "url": "https://glygen.org/publication/PubMed/17088211" } ] }, { "title": "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission.", "journal": "Neuron", "date": "2006", "authors": "Rial Verde EM, Lee-Osbourne J, Worley PF, Malinow R, Cline HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17088212", "url": "https://glygen.org/publication/PubMed/17088212" } ] }, { "title": "The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.", "journal": "Cell", "date": "2006", "authors": "Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "17129783", "url": "https://glygen.org/publication/PubMed/17129783" } ] }, { "title": "RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking.", "journal": "Experimental cell research", "date": "2007", "authors": "Wallar BJ, Deward AD, Resau JH, Alberts AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "17198702", "url": "https://glygen.org/publication/PubMed/17198702" } ] }, { "title": "G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.", "journal": "Cancer research", "date": "2007", "authors": "Albanito L, Madeo A, Lappano R, Vivacqua A, Rago V, Carpino A, Oprea TI, Prossnitz ER, Musti AM, Ando S, Maggiolini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "17308128", "url": "https://glygen.org/publication/PubMed/17308128" } ] }, { "title": "Profilin-actin complexes directly elongate actin filaments at the barbed end.", "journal": "Biochemistry", "date": "1992", "authors": "Pring M, Weber A, Bubb MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "1737036", "url": "https://glygen.org/publication/PubMed/1737036" } ] }, { "title": "Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.", "journal": "The EMBO journal", "date": "1992", "authors": "Marais RM, Hsuan JJ, McGuigan C, Wynne J, Treisman R", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "1740119", "url": "https://glygen.org/publication/PubMed/1740119" } ] }, { "title": "The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression.", "journal": "Cell", "date": "2007", "authors": "Giorgi C, Yeo GW, Stone ME, Katz DB, Burge C, Turrigiano G, Moore MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17632064", "url": "https://glygen.org/publication/PubMed/17632064" } ] }, { "title": "Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF.", "journal": "Nucleic Acids Res.", "date": "2007", "authors": "Freddie CT, Ji Z, Marais A, Sharrocks AD", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "17670796", "url": "https://glygen.org/publication/PubMed/17670796" } ] }, { "title": "Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2007", "authors": "Messaoudi E, Kanhema T, Soule J, Tiron A, Dagyte G, da Silva B, Bramham CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "17898216", "url": "https://glygen.org/publication/PubMed/17898216" } ] }, { "title": "High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.", "journal": "Journal of molecular biology", "date": "2008", "authors": "Kursula P, Kursula I, Massimi M, Song YH, Downer J, Stanley WA, Witke W, Wilmanns M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "18001770", "url": "https://glygen.org/publication/PubMed/18001770" } ] }, { "title": "Rad GTPase deficiency leads to cardiac hypertrophy.", "journal": "Circulation", "date": "2007", "authors": "Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Bruning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18056528", "url": "https://glygen.org/publication/PubMed/18056528" } ] }, { "title": "Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation.", "journal": "Journal of neurochemistry", "date": "2008", "authors": "Tyan SW, Tsai MC, Lin CL, Ma YL, Lee EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18088355", "url": "https://glygen.org/publication/PubMed/18088355" } ] }, { "title": "Molecular architecture of the kinetochore-microtubule interface.", "journal": "Nature reviews. Molecular cell biology", "date": "2008", "authors": "Cheeseman IM, Desai A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "18097444", "url": "https://glygen.org/publication/PubMed/18097444" } ] }, { "title": "Lyl1 interacts with CREB1 and alters expression of CREB1 target genes.", "journal": "Biochimica et biophysica acta", "date": "2008", "authors": "San-Marina S, Han Y, Suarez Saiz F, Trus MR, Minden MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18160048", "url": "https://glygen.org/publication/PubMed/18160048" } ] }, { "title": "Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements.", "journal": "Oncogene", "date": "1991", "authors": "Alexandre C, Charnay P, Verrier B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1833716", "url": "https://glygen.org/publication/PubMed/1833716" } ] }, { "title": "A brief introduction to FOXOlogy.", "journal": "Oncogene", "date": "2008", "authors": "Burgering BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "18391968", "url": "https://glygen.org/publication/PubMed/18391968" } ] }, { "title": "Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Mager GM, Ward RM, Srinivasan R, Jang SW, Wrabetz L, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18456662", "url": "https://glygen.org/publication/PubMed/18456662" } ] }, { "title": "Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells.", "journal": "Endocrinology", "date": "2008", "authors": "Albanito L, Sisci D, Aquila S, Brunelli E, Vivacqua A, Madeo A, Lappano R, Pandey DP, Picard D, Mauro L, Ando S, Maggiolini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "18467441", "url": "https://glygen.org/publication/PubMed/18467441" } ] }, { "title": "The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.", "journal": "Circ. Res.", "date": "2008", "authors": "Sundberg-Smith LJ, DiMichele LA, Sayers RL, Mack CP, Taylor JM", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "18497331", "url": "https://glygen.org/publication/PubMed/18497331" } ] }, { "title": "Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2008", "authors": "Desmazieres A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "18524893", "url": "https://glygen.org/publication/PubMed/18524893" } ] }, { "title": "Nucleotide sequence and regulatory studies of VGF, a nervous system-specific mRNA that is rapidly and relatively selectively induced by nerve growth factor.", "journal": "Journal of neurochemistry", "date": "1991", "authors": "Salton SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "1861162", "url": "https://glygen.org/publication/PubMed/1861162" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation.", "journal": "Journal of neurotrauma", "date": "2008", "authors": "Yune TY, Park HG, Lee JY, Oh TH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "18785877", "url": "https://glygen.org/publication/PubMed/18785877" } ] }, { "title": "Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.", "journal": "The EMBO journal", "date": "2008", "authors": "Breitsprecher D, Kiesewetter AK, Linkner J, Urbanke C, Resch GP, Small JV, Faix J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "18923426", "url": "https://glygen.org/publication/PubMed/18923426" } ] }, { "title": "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.", "journal": "Molecular cell", "date": "2008", "authors": "Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19061646", "url": "https://glygen.org/publication/PubMed/19061646" } ] }, { "title": "Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19116276", "url": "https://glygen.org/publication/PubMed/19116276" } ] }, { "title": "The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2009", "authors": "Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19193899", "url": "https://glygen.org/publication/PubMed/19193899" } ] }, { "title": "Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2009", "authors": "Toshinai K, Nakazato M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19194657", "url": "https://glygen.org/publication/PubMed/19194657" } ] }, { "title": "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.", "journal": "Nat. Cell Biol.", "date": "2009", "authors": "Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "19350017", "url": "https://glygen.org/publication/PubMed/19350017" } ] }, { "title": "NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.", "journal": "PloS one", "date": "2009-05-28", "authors": "Riazi Ali M, Takeuchi Jun K, Hornberger Lisa K, Zaidi Syed Hassan, Amini Fariba, Coles John, Bruneau Benoit G, Van Arsdell Glen S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709" } ], "reference": [ { "type": "PubMed", "id": "19479054", "url": "https://glygen.org/publication/PubMed/19479054" } ] }, { "title": "Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.", "journal": "Cancer research", "date": "2009", "authors": "Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "19549922", "url": "https://glygen.org/publication/PubMed/19549922" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2009", "authors": "Blaker AL, Taylor JM, Mack CP", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "19778940", "url": "https://glygen.org/publication/PubMed/19778940" } ] }, { "title": "Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Han Y, Eppinger E, Schuster IG, Weigand LU, Liang X, Kremmer E, Peschel C, Krackhardt AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "19815554", "url": "https://glygen.org/publication/PubMed/19815554" } ] }, { "title": "Cell proliferation regulated by estradiol receptor: Therapeutic implications.", "journal": "Steroids", "date": "2010", "authors": "Castoria G, Migliaccio A, Giovannelli P, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "19879889", "url": "https://glygen.org/publication/PubMed/19879889" } ] }, { "title": "Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.", "journal": "Circulation research", "date": "2010", "authors": "Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "19926875", "url": "https://glygen.org/publication/PubMed/19926875" } ] }, { "title": "[PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin-induced platelet aggregation].", "journal": "Zhongguo shi yan xue ye xue za zhi", "date": "2009", "authors": "Gao GX, Dong HJ, Gu HT, Gao Y, Pan YZ, Yang Y, Chen XQ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "20030946", "url": "https://glygen.org/publication/PubMed/20030946" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.", "journal": "Cancer research", "date": "2010", "authors": "Ariazi EA, Brailoiu E, Yerrum S, Shupp HA, Slifker MJ, Cunliffe HE, Black MA, Donato AL, Arterburn JB, Oprea TI, Prossnitz ER, Dun NJ, Jordan VC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "20086172", "url": "https://glygen.org/publication/PubMed/20086172" } ] }, { "title": "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC.", "journal": "Oncogene", "date": "2010", "authors": "Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "20101212", "url": "https://glygen.org/publication/PubMed/20101212" } ] }, { "title": "Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells.", "journal": "Molecular and cellular biology", "date": "1991", "authors": "Salton SR, Fischberg DJ, Dong KW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2017159", "url": "https://glygen.org/publication/PubMed/2017159" } ] }, { "title": "v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Qureshi SA, Cao XM, Sukhatme VP, Foster DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2040600", "url": "https://glygen.org/publication/PubMed/2040600" } ] }, { "title": "Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II.", "journal": "Molecular and cellular biology", "date": "1991", "authors": "Manak JR, Prywes R", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "2046671", "url": "https://glygen.org/publication/PubMed/2046671" } ] }, { "title": "EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.", "journal": "Journal of cellular biochemistry", "date": "2010", "authors": "Kumbrink J, Kirsch KH, Johnson JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "20506119", "url": "https://glygen.org/publication/PubMed/20506119" } ] }, { "title": "5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.", "journal": "Oncogene", "date": "1991", "authors": "Sakamoto KM, Bardeleben C, Yates KE, Raines MA, Golde DW, Gasson JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2052361", "url": "https://glygen.org/publication/PubMed/2052361" } ] }, { "title": "RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking.", "journal": "Endocrinology", "date": "2010", "authors": "Li D, Sewer MB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "20591975", "url": "https://glygen.org/publication/PubMed/20591975" } ] }, { "title": "The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.", "journal": "Molecular and cellular biology", "date": "1991", "authors": "Crosby SD, Puetz JJ, Simburger KS, Fahrner TJ, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2072895", "url": "https://glygen.org/publication/PubMed/2072895" } ] }, { "title": "Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity.", "journal": "Communicative & integrative biology", "date": "2010", "authors": "Inoue M, Yagishita-Kyo N, Nonaka M, Kawashima T, Okuno H, Bito H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21057636", "url": "https://glygen.org/publication/PubMed/21057636" } ] }, { "title": "NADPH oxidase 4 mediates TGF-beta-induced smooth muscle alpha-actin via p38MAPK and serum response factor.", "journal": "Free radical biology & medicine", "date": "2011", "authors": "Martin-Garrido A, Brown DI, Lyle AN, Dikalova A, Seidel-Rogol B, Lassegue B, San Martin A, Griendling KK", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "21074607", "url": "https://glygen.org/publication/PubMed/21074607" } ] }, { "title": "Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.", "journal": "Molecular and cellular biology", "date": "1990", "authors": "Cao XM, Koski RA, Gashler A, McKiernan M, Morris CF, Gaffney R, Hay RV, Sukhatme VP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2109185", "url": "https://glygen.org/publication/PubMed/2109185" } ] }, { "title": "Bi-modal regulation of a formin by srGAP2.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Mason FM, Heimsath EG, Higgs HN, Soderling SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "21148482", "url": "https://glygen.org/publication/PubMed/21148482" } ] }, { "title": "Activation and function of immediate-early genes in the nervous system.", "journal": "Biochemistry and cell biology = Biochimie et biologie cellulaire", "date": "2011", "authors": "Perez-Cadahia B, Drobic B, Davie JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21326363", "url": "https://glygen.org/publication/PubMed/21326363" } ] }, { "title": "Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment.", "journal": "Developmental cell", "date": "2011", "authors": "Cheng L, Zhang J, Ahmad S, Rozier L, Yu H, Deng H, Mao Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "21397845", "url": "https://glygen.org/publication/PubMed/21397845" } ] }, { "title": "ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis.", "journal": "Journal of cell science", "date": "2011", "authors": "Hong SH, Lee JH, Lee JB, Ji J, Bhatia M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21486943", "url": "https://glygen.org/publication/PubMed/21486943" } ] }, { "title": "RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.", "journal": "The Journal of cell biology", "date": "2011", "authors": "Vega FM, Fruhwirth G, Ng T, Ridley AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "21576392", "url": "https://glygen.org/publication/PubMed/21576392" } ] }, { "title": "VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers.", "journal": "Journal of chemical neuroanatomy", "date": "2011", "authors": "Ferri GL, Noli B, Brancia C, D'Amato F, Cocco C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "21621608", "url": "https://glygen.org/publication/PubMed/21621608" } ] }, { "title": "Dynamic remodeling of the actin cytoskeleton by FMNL1gamma is required for structural maintenance of the Golgi complex.", "journal": "Journal of cell science", "date": "2011", "authors": "Colon-Franco JM, Gomez TS, Billadeau DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "21868368", "url": "https://glygen.org/publication/PubMed/21868368" } ] }, { "title": "Early growth response 1--a transcription factor in the crossfire of signal transduction cascades.", "journal": "Indian journal of biochemistry & biophysics", "date": "2011", "authors": "Pagel JI, Deindl E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "22053691", "url": "https://glygen.org/publication/PubMed/22053691" } ] }, { "title": "Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Mullenbrock S, Shah J, Cooper GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "22065583", "url": "https://glygen.org/publication/PubMed/22065583" } ] }, { "title": "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Heimsath EG Jr, Higgs HN", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "22094460", "url": "https://glygen.org/publication/PubMed/22094460" } ] }, { "title": "Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells.", "journal": "Oncogene", "date": "2012", "authors": "Castoria G, Giovannelli P, Lombardi M, De Rosa C, Giraldi T, de Falco A, Barone MV, Abbondanza C, Migliaccio A, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "22266855", "url": "https://glygen.org/publication/PubMed/22266855" } ] }, { "title": "The formin FMNL3 is a cytoskeletal regulator of angiogenesis.", "journal": "Journal of cell science", "date": "2012", "authors": "Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R, Mellor H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "22275430", "url": "https://glygen.org/publication/PubMed/22275430" } ] }, { "title": "The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2012", "authors": "Hung H, Kohnken R, Svaren J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "22302795", "url": "https://glygen.org/publication/PubMed/22302795" } ] }, { "title": "Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.", "journal": "Thrombosis research", "date": "1990", "authors": "Fleck RA, Rao LV, Rapaport SI, Varki N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2237820", "url": "https://glygen.org/publication/PubMed/2237820" } ] }, { "title": "FMNL2 drives actin-based protrusion and migration downstream of Cdc42.", "journal": "Current biology : CB", "date": "2012", "authors": "Block J, Breitsprecher D, Kuhn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "22608513", "url": "https://glygen.org/publication/PubMed/22608513" } ] }, { "title": "Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3.", "journal": "Bioscience, biotechnology, and biochemistry", "date": "2012", "authors": "Moriya K, Yamamoto T, Takamitsu E, Matsunaga Y, Kimoto M, Fukushige D, Kimoto C, Suzuki T, Utsumi T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "22790947", "url": "https://glygen.org/publication/PubMed/22790947" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.", "journal": "Nature structural & molecular biology", "date": "2013", "authors": "Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "23222643", "url": "https://glygen.org/publication/PubMed/23222643" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "FMNL1 promotes proliferation and migration of leukemia cells.", "journal": "Journal of leukocyte biology", "date": "2013", "authors": "Favaro P, Traina F, Machado-Neto JA, Lazarini M, Lopes MR, Pereira JK, Costa FF, Infante E, Ridley AJ, Saad ST", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "23801653", "url": "https://glygen.org/publication/PubMed/23801653" } ] }, { "title": "Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor alpha (ERalpha).", "journal": "PloS one", "date": "2013", "authors": "Tsai CL, Wu HM, Lin CY, Lin YJ, Chao A, Wang TH, Hsueh S, Lai CH, Wang HS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "24039841", "url": "https://glygen.org/publication/PubMed/24039841" } ] }, { "title": "Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes.", "journal": "The American journal of gastroenterology", "date": "2013", "authors": "Grasberger H, Chang L, Shih W, Presson AP, Sayuk GS, Newberry RD, Karagiannides I, Pothoulakis C, Mayer E, Merchant JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "24060757", "url": "https://glygen.org/publication/PubMed/24060757" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs.", "journal": "Biochimica et biophysica acta", "date": "2014", "authors": "Bersten DC, Wright JA, McCarthy PJ, Whitelaw ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-9768777", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9768777" } ], "reference": [ { "type": "PubMed", "id": "24291638", "url": "https://glygen.org/publication/PubMed/24291638" } ] }, { "title": "Formins as effector proteins of Rho GTPases.", "journal": "Small GTPases", "date": "2014", "authors": "Kuhn S, Geyer M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "24914801", "url": "https://glygen.org/publication/PubMed/24914801" } ] }, { "title": "Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation.", "journal": "Stem cells (Dayton, Ohio)", "date": "2015", "authors": "Den Hartogh SC, Schreurs C, Monshouwer-Kloots JJ, Davis RP, Elliott DA, Mummery CL, Passier R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709" } ], "reference": [ { "type": "PubMed", "id": "25187301", "url": "https://glygen.org/publication/PubMed/25187301" } ] }, { "title": "Id proteins: small molecules, mighty regulators.", "journal": "Current topics in developmental biology", "date": "2014", "authors": "Ling F, Kang B, Sun XH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "25248477", "url": "https://glygen.org/publication/PubMed/25248477" } ] }, { "title": "Olfactomedin 2, a novel regulator for transforming growth factor-beta-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells.", "journal": "Mol. Biol. Cell", "date": "2014", "authors": "Shi N, Guo X, Chen SY", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "25298399", "url": "https://glygen.org/publication/PubMed/25298399" } ] }, { "title": "Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.", "journal": "Neuroreport", "date": "2015", "authors": "Moon SM, Kim JS, Park BR, Kim DK, Kim SG, Kim HJ, Chun HS, Lee BK, Kim CS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "25569790", "url": "https://glygen.org/publication/PubMed/25569790" } ] }, { "title": "Arc is a flexible modular protein capable of reversible self-oligomerization.", "journal": "The Biochemical journal", "date": "2015", "authors": "Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuellar J, Haavik J, Soule J, Valpuesta JM, Marquez JA, Martinez A, Bramham CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "25748042", "url": "https://glygen.org/publication/PubMed/25748042" } ] }, { "title": "How it all starts: Initiation of the clotting cascade.", "journal": "Critical reviews in biochemistry and molecular biology", "date": "2015", "authors": "Smith SA, Travers RJ, Morrissey JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "26018600", "url": "https://glygen.org/publication/PubMed/26018600" } ] }, { "title": "p27(Kip1) signaling: Transcriptional and post-translational regulation.", "journal": "The international journal of biochemistry & cell biology", "date": "2015", "authors": "Hnit SS, Xie C, Yao M, Holst J, Bensoussan A, De Souza P, Li Z, Dong Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "26279144", "url": "https://glygen.org/publication/PubMed/26279144" } ] }, { "title": "A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway.", "journal": "The EMBO journal", "date": "1989", "authors": "Possenti R, Eldridge JD, Paterson BM, Grasso A, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "2676516", "url": "https://glygen.org/publication/PubMed/2676516" } ] }, { "title": "A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.", "journal": "Scientific reports", "date": "2016-01-19", "authors": "den Hartogh Sabine C, Wolstencroft Katherine, Mummery Christine L, Passier Robert", "evidence": [ { "database": "Reactome", "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709" } ], "reference": [ { "type": "PubMed", "id": "26783251", "url": "https://glygen.org/publication/PubMed/26783251" } ] }, { "title": "Structural Basis for Substrate Selectivity of the E3 Ligase COP1.", "journal": "Structure (London, England : 1993)", "date": "2016", "authors": "Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "27041596", "url": "https://glygen.org/publication/PubMed/27041596" } ] }, { "title": "Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances.", "journal": "PloS one", "date": "2016", "authors": "Zhao Q, Chang C, Gonzalez JP, Alzahrani K, Button JL, Fraidenraich D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "27128622", "url": "https://glygen.org/publication/PubMed/27128622" } ] }, { "title": "Gene regulation in the immediate-early response process.", "journal": "Advances in biological regulation", "date": "2016", "authors": "Bahrami S, Drablos F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "27220739", "url": "https://glygen.org/publication/PubMed/27220739" } ] }, { "title": "The emerging role of estrogen in B cell malignancies.", "journal": "Leukemia & lymphoma", "date": "2017", "authors": "Ladikou EE, Kassi E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "27557932", "url": "https://glygen.org/publication/PubMed/27557932" } ] }, { "title": "Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors.", "journal": "Pharmacological research", "date": "2017", "authors": "Thiel G, Rossler OG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "28012964", "url": "https://glygen.org/publication/PubMed/28012964" } ] }, { "title": "Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells.", "journal": "PloS one", "date": "2017", "authors": "Adams KW, Kletsov S, Lamm RJ, Elman JS, Mullenbrock S, Cooper GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "28076410", "url": "https://glygen.org/publication/PubMed/28076410" } ] }, { "title": "Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.", "journal": "The Biochemical journal", "date": "2017", "authors": "Hooker E, Baldwin C, Roodman V, Batra A, Isa NN, Takano T, Lemay S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "28275114", "url": "https://glygen.org/publication/PubMed/28275114" } ] }, { "title": "ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription.", "journal": "Molecular cell", "date": "2017", "authors": "Esnault C, Gualdrini F, Horswell S, Kelly G, Stewart A, East P, Matthews N, Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "28286024", "url": "https://glygen.org/publication/PubMed/28286024" } ] }, { "title": "A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis.", "journal": "The Journal of steroid biochemistry and molecular biology", "date": "2018", "authors": "Filardo EJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "28595943", "url": "https://glygen.org/publication/PubMed/28595943" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" }, { "database": "O-GlcNAc Atlas", "id": "P11831", "url": "https://oglcnac.org/atlas/detail/P11831" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "The Arc of cognition: Signaling cascades regulating Arc and implications for cognitive function and disease.", "journal": "Seminars in cell & developmental biology", "date": "2018", "authors": "Epstein I, Finkbeiner S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "29559111", "url": "https://glygen.org/publication/PubMed/29559111" } ] }, { "title": "NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.", "journal": "Nature communications", "date": "2018", "authors": "Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709" } ], "reference": [ { "type": "PubMed", "id": "29636455", "url": "https://glygen.org/publication/PubMed/29636455" } ] }, { "title": "A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.", "journal": "Cell", "date": "1988", "authors": "Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "3127059", "url": "https://glygen.org/publication/PubMed/3127059" } ] }, { "title": "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.", "journal": "Cell", "date": "1988", "authors": "Norman C, Runswick M, Pollock R, Treisman R", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "3203386", "url": "https://glygen.org/publication/PubMed/3203386" } ] }, { "title": "Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure.", "journal": "Circulation", "date": "2020", "authors": "Li J, Tan Y, Passariello CL, Martinez EC, Kritzer MD, Li X, Li X, Li Y, Yu Q, Ohgi K, Thakur H, MacArthur JW Jr, Ivey JR, Woo YJ, Emter CA, Dodge-Kafka K, Rosenfeld MG, Kapiloff MS", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "32933333", "url": "https://glygen.org/publication/PubMed/32933333" } ] }, { "title": "GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm.", "journal": "eLife", "date": "2020-10-15", "authors": "Sharma Arun, Wasson Lauren K, Willcox Jon Al, Morton Sarah U, Gorham Joshua M, DeLaughter Daniel M, Neyazi Meraj, Schmid Manuel, Agarwal Radhika, Jang Min Young, Toepfer Christopher N, Ward Tarsha, Kim Yuri, Pereira Alexandre C, DePalma Steven R, Tai Angela, Kim Seongwon, Conner David, Bernstein Daniel, Gelb Bruce D, Chung Wendy K, Goldmuntz Elizabeth, Porter George, Tristani-Firouzi Martin, Srivastava Deepak, Seidman Jonathan G, Seidman Christine E,", "evidence": [ { "database": "Reactome", "id": "R-HSA-9733709", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709" } ], "reference": [ { "type": "PubMed", "id": "33054971", "url": "https://glygen.org/publication/PubMed/33054971" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes.", "journal": "Reproductive biomedicine online", "date": "2021", "authors": "Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT Jr", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" } ], "reference": [ { "type": "PubMed", "id": "34417138", "url": "https://glygen.org/publication/PubMed/34417138" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11831" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "IGF2BP2, an RNA-binding protein regulates cell proliferation and osteogenic differentiation by stabilizing SRF mRNA.", "journal": "Journal of cellular physiology", "date": "2022-11-27", "authors": "Zhou Zimo, Chen Senxiang, Wu Tong, Chen Yifeng, Cao Yuxiao, Huang Ying, Liu Da", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" } ], "reference": [ { "type": "PubMed", "id": "36436184", "url": "https://glygen.org/publication/PubMed/36436184" } ] }, { "title": "SRF/MRTF-A and liver cirrhosis: Pathologic associations.", "journal": "Journal of digestive diseases", "date": "2022-11", "authors": "Al-Hetty Hussein Riyadh Abdul Kareem, Ismaeel Ghufran Lutfi, Mohammad Walid Theib, Toama Mariam Alaa, Kandeel Mahmoud, Saleh Marwan Mahmood, Turki Jalil Abduladheem", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" } ], "reference": [ { "type": "PubMed", "id": "36601855", "url": "https://glygen.org/publication/PubMed/36601855" } ] }, { "title": "A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.", "journal": "Science (New York, N.Y.)", "date": "1987", "authors": "Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "3672127", "url": "https://glygen.org/publication/PubMed/3672127" } ] }, { "title": "Cellular myofibromas with SRF fusions: clinicopathological and molecular study of 3 cases of a rare entity and a potential mimic of sarcoma.", "journal": "Human pathology", "date": "2023-08", "authors": "Papa Brigitte, Nguyen Minh Anh, Kumar Amit, Song Liyan, Dorwal Pranav, Cheah Alison L", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" } ], "reference": [ { "type": "PubMed", "id": "37245628", "url": "https://glygen.org/publication/PubMed/37245628" } ] }, { "title": "Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.", "journal": "British journal of cancer", "date": "2023-08-09", "authors": "Park Junseong, Shim Jin-Kyoung, Lee Mirae, Kim Dokyeong, Yoon Seon-Jin, Moon Ju Hyung, Kim Eui Hyun, Park Jeong-Yoon, Chang Jong Hee, Kang Seok-Gu", "evidence": [ { "database": "RefSeq", "id": "NP_001278930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278930" } ], "reference": [ { "type": "PubMed", "id": "37558923", "url": "https://glygen.org/publication/PubMed/37558923" } ] }, { "title": "Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.", "journal": "Molecular and cellular neurosciences", "date": "1995", "authors": "Bonni A, Ginty DD, Dudek H, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7551568", "url": "https://glygen.org/publication/PubMed/7551568" } ] }, { "title": "Journey to the surface of the cell: Fos regulation and the SRE.", "journal": "The EMBO journal", "date": "1995", "authors": "Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "7588619", "url": "https://glygen.org/publication/PubMed/7588619" } ] }, { "title": "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7592934", "url": "https://glygen.org/publication/PubMed/7592934" } ] }, { "title": "Tissue-specific processing of the neuroendocrine protein VGF.", "journal": "Journal of neurochemistry", "date": "1995", "authors": "Trani E, Ciotti T, Rinaldi AM, Canu N, Ferri GL, Levi A, Possenti R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7595538", "url": "https://glygen.org/publication/PubMed/7595538" } ] }, { "title": "Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Lee HJ, Mignacca RC, Sakamoto KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7608156", "url": "https://glygen.org/publication/PubMed/7608156" } ] }, { "title": "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Russo MW, Sevetson BR, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7624335", "url": "https://glygen.org/publication/PubMed/7624335" } ] }, { "title": "Structure of serum response factor core bound to DNA.", "journal": "Nature", "date": "1995", "authors": "Pellegrini L, Tan S, Richmond T J", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "reference": [ { "type": "PubMed", "id": "7637780", "url": "https://glygen.org/publication/PubMed/7637780" } ] }, { "title": "Somatodendritic expression of an immediate early gene is regulated by synaptic activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Link W, Konietzko U, Kauselmann G, Krug M, Schwanke B, Frey U, Kuhl D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7777577", "url": "https://glygen.org/publication/PubMed/7777577" } ] }, { "title": "A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "McMahon SB, Monroe JG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7823924", "url": "https://glygen.org/publication/PubMed/7823924" } ] }, { "title": "Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.", "journal": "Neuron", "date": "1995", "authors": "Lyford GL, Yamagata K, Kaufmann WE, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7857651", "url": "https://glygen.org/publication/PubMed/7857651" } ] }, { "title": "The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.", "journal": "Science (New York, N.Y.)", "date": "1995", "authors": "Schoenherr CJ, Anderson DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7871435", "url": "https://glygen.org/publication/PubMed/7871435" } ] }, { "title": "Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Zhu J, Reynet C, Caldwell JS, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7876254", "url": "https://glygen.org/publication/PubMed/7876254" } ] }, { "title": "ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.", "journal": "The EMBO journal", "date": "1995", "authors": "Gille H, Kortenjann M, Thomae O, Moomaw C, Slaughter C, Cobb MH, Shaw PE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "7889942", "url": "https://glygen.org/publication/PubMed/7889942" } ] }, { "title": "Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.", "journal": "Cell", "date": "1994", "authors": "Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "7923378", "url": "https://glygen.org/publication/PubMed/7923378" } ] }, { "title": "L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response factor-dependent pathway.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Misra RP, Bonni A, Miranti CK, Rivera VM, Sheng M, Greenberg ME", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "7929249", "url": "https://glygen.org/publication/PubMed/7929249" } ] }, { "title": "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.", "journal": "Nature", "date": "1994", "authors": "Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8090221", "url": "https://glygen.org/publication/PubMed/8090221" } ] }, { "title": "A brain-specific activator of cyclin-dependent kinase 5.", "journal": "Nature", "date": "1994", "authors": "Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, Wang JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8090222", "url": "https://glygen.org/publication/PubMed/8090222" } ] }, { "title": "Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.", "journal": "Science (New York, N.Y.)", "date": "1993", "authors": "Reynet C, Kahn CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8248782", "url": "https://glygen.org/publication/PubMed/8248782" } ] }, { "title": "C-terminal phosphorylation of the serum-response factor.", "journal": "European journal of biochemistry", "date": "1993", "authors": "Janknecht R, Ernst WH, Houthaeve T, Nordheim A", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "8375385", "url": "https://glygen.org/publication/PubMed/8375385" } ] }, { "title": "The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain.", "journal": "Cell", "date": "1993", "authors": "Marais R, Wynne J, Treisman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "8386592", "url": "https://glygen.org/publication/PubMed/8386592" } ] }, { "title": "The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Liu SH, Ma JT, Yueh AY, Lees-Miller SP, Anderson CW, Ng SY", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "8407951", "url": "https://glygen.org/publication/PubMed/8407951" } ] }, { "title": "A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.", "journal": "Molecular and cellular biology", "date": "1993", "authors": "Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME", "evidence": [ { "database": "iPTMnet", "id": "P11831", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11831" } ], "reference": [ { "type": "PubMed", "id": "8413226", "url": "https://glygen.org/publication/PubMed/8413226" } ] }, { "title": "Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.", "journal": "Molecular and cellular biology", "date": "1993", "authors": "Russo MW, Matheny C, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8413279", "url": "https://glygen.org/publication/PubMed/8413279" } ] }, { "title": "Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "1993", "authors": "DeFranco C, Damon DH, Endoh M, Wagner JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8483478", "url": "https://glygen.org/publication/PubMed/8483478" } ] }, { "title": "Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Cui MZ, Parry GC, Oeth P, Larson H, Smith M, Huang RP, Adamson ED, Mackman N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8576248", "url": "https://glygen.org/publication/PubMed/8576248" } ] }, { "title": "Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma.", "journal": "The Journal of urology", "date": "1996", "authors": "Thigpen AE, Cala KM, Guileyardo JM, Molberg KH, McConnell JD, Russell DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8583621", "url": "https://glygen.org/publication/PubMed/8583621" } ] }, { "title": "Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.", "journal": "The EMBO journal", "date": "1996", "authors": "Migliaccio A, Di Domenico M, Castoria G, de Falco A, Bontempo P, Nola E, Auricchio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "8635462", "url": "https://glygen.org/publication/PubMed/8635462" } ] }, { "title": "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8668170", "url": "https://glygen.org/publication/PubMed/8668170" } ] }, { "title": "Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "D'Arcangelo G, Habas R, Wang S, Halegoua S, Salton SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8756618", "url": "https://glygen.org/publication/PubMed/8756618" } ] }, { "title": "The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.", "journal": "Genes & development", "date": "1996", "authors": "Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8846918", "url": "https://glygen.org/publication/PubMed/8846918" } ] }, { "title": "The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation.", "journal": "Molecular and cellular neurosciences", "date": "1996", "authors": "Zorick TS, Syroid DE, Arroyo E, Scherer SS, Lemke G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "8918830", "url": "https://glygen.org/publication/PubMed/8918830" } ] }, { "title": "Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Di Rocco G, Pennuto M, Illi B, Canu N, Filocamo G, Trani E, Rinaldi AM, Possenti R, Mandolesi G, Sirinian MI, Jucker R, Levi A, Nasi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9032251", "url": "https://glygen.org/publication/PubMed/9032251" } ] }, { "title": "The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.", "journal": "Genes & development", "date": "1997", "authors": "Reynisdottir I, Massague J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "9042862", "url": "https://glygen.org/publication/PubMed/9042862" } ] }, { "title": "Molecular cloning and characterization of the human VGF promoter region.", "journal": "Journal of neurochemistry", "date": "1997", "authors": "Canu N, Possenti R, Rinaldi AM, Trani E, Levi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9084409", "url": "https://glygen.org/publication/PubMed/9084409" } ] }, { "title": "Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Aktas H, Cai H, Cooper GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "9199319", "url": "https://glygen.org/publication/PubMed/9199319" } ] }, { "title": "Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.", "journal": "Oncogene", "date": "1997", "authors": "Kawada M, Yamagoe S, Murakami Y, Suzuki K, Mizuno S, Uehara Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "9264403", "url": "https://glygen.org/publication/PubMed/9264403" } ] }, { "title": "Role of cyclins in neuronal differentiation of immortalized hippocampal cells.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Xiong W, Pestell R, Rosner MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9343422", "url": "https://glygen.org/publication/PubMed/9343422" } ] }, { "title": "CREB: a major mediator of neuronal neurotrophin responses.", "journal": "Neuron", "date": "1997", "authors": "Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9390517", "url": "https://glygen.org/publication/PubMed/9390517" } ] }, { "title": "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9418898", "url": "https://glygen.org/publication/PubMed/9418898" } ] }, { "title": "Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Cheng M, Sexl V, Sherr CJ, Roussel MF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638" } ], "reference": [ { "type": "PubMed", "id": "9448290", "url": "https://glygen.org/publication/PubMed/9448290" } ] }, { "title": "Expression of early growth response genes in human prostate cancer.", "journal": "Cancer research", "date": "1998", "authors": "Eid MA, Kumar MV, Iczkowski KA, Bostwick DG, Tindall DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9622090", "url": "https://glygen.org/publication/PubMed/9622090" } ] }, { "title": "The role of profilin in actin polymerization and nucleotide exchange.", "journal": "Biochemistry", "date": "1998", "authors": "Korenbaum E, Nordberg P, Bjorkegren-Sjogren C, Schutt CE, Lindberg U, Karlsson R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "9649308", "url": "https://glygen.org/publication/PubMed/9649308" } ] }, { "title": "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells.", "journal": "The Journal of cell biology", "date": "1998", "authors": "Qu Z, Wolfraim LA, Svaren J, Ehrengruber MU, Davidson N, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9722618", "url": "https://glygen.org/publication/PubMed/9722618" } ] }, { "title": "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "De Cesare D, Jacquot S, Hanauer A, Sassone-Corsi P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9770464", "url": "https://glygen.org/publication/PubMed/9770464" } ] }, { "title": "Novel mutants of NAB corepressors enhance activation by Egr transactivators.", "journal": "The EMBO journal", "date": "1998", "authors": "Svaren J, Sevetson BR, Golda T, Stanton JJ, Swirnoff AH, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9774344", "url": "https://glygen.org/publication/PubMed/9774344" } ] }, { "title": "Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.", "journal": "Neuron", "date": "1998", "authors": "Steward O, Wallace CS, Lyford GL, Worley PF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9808461", "url": "https://glygen.org/publication/PubMed/9808461" } ] }, { "title": "Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "1998", "authors": "Paglini G, Pigino G, Kunda P, Morfini G, Maccioni R, Quiroga S, Ferreira A, Caceres A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9822744", "url": "https://glygen.org/publication/PubMed/9822744" } ] }, { "title": "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.", "journal": "Brain research. Brain research reviews", "date": "1998", "authors": "Herdegen T, Leah JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9031628", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628" } ], "reference": [ { "type": "PubMed", "id": "9858769", "url": "https://glygen.org/publication/PubMed/9858769" } ] } ], "pathway": [ { "id": "hsa:6722", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6722", "resource": "KEGG Pathway" }, { "id": "R-HSA-5663220", "name": "RHO GTPases Activate Formins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-HSA-9031628", "name": "NGF-stimulated transcription", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9031628", "resource": "Reactome", "description": "NGF-stimulated transcription" }, { "id": "R-HSA-9634638", "name": "Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634638", "resource": "Reactome", "description": "Estrogen-dependent nuclear events downstream of ESR-membrane signaling" }, { "id": "R-HSA-9733709", "name": "Cardiogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733709", "resource": "Reactome", "description": "Cardiogenesis" }, { "id": "R-HSA-9768777", "name": "Regulation of NPAS4 gene transcription", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9768777", "resource": "Reactome", "description": "Regulation of NPAS4 gene transcription" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZHH8-1", "protein_name": "Serum response factor", "gene_name": "Srf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPSQAGAAAALGRGSALGGSLNRTPTGRPGGSGGTRGANGGRVPGNGAGLGPGRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPSTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE", "length": 504 }, "evidence": [ { "id": "45917064", "url": "http://www.informatics.jax.org/homology/45917064", "database": "MGI" }, { "id": "P11831", "url": "https://omabrowser.org/oma/group/P11831/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JM73-1", "protein_name": "Serum response factor", "gene_name": "Srf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPSQAGAAAALGRGSALGGNLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGQSRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE", "length": 504 }, "evidence": [ { "id": "45917064", "url": "http://www.informatics.jax.org/homology/45917064", "database": "MGI" }, { "id": "P11831", "url": "https://omabrowser.org/oma/group/P11831/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 69, "go_terms": [ { "name": "thyroid gland development", "id": "GO:0030878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030878", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of transcription initiation by RNA polymerase II", "id": "GO:0060261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of transcription by glucose", "id": "GO:0046016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046016", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cardiac muscle cell myoblast differentiation", "id": "GO:0060379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060379", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "trachea cartilage development", "id": "GO:0060534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060534", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "associative learning", "id": "GO:0008306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008306", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of smooth muscle contraction", "id": "GO:0045987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045987", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "muscle cell cellular homeostasis", "id": "GO:0046716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046716", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "filopodium assembly", "id": "GO:0046847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046847", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of DNA-binding transcription factor activity", "id": "GO:0051091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051091", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "establishment of skin barrier", "id": "GO:0061436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "hippocampus development", "id": "GO:0021766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021766", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "hematopoietic stem cell differentiation", "id": "GO:0060218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060218", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "long-term synaptic depression", "id": "GO:0060292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060292", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "trophectodermal cell differentiation", "id": "GO:0001829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001829", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "platelet activation", "id": "GO:0030168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030168", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of cell differentiation", "id": "GO:0045597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045597", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "response to toxic substance", "id": "GO:0009636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cardiac myofibril assembly", "id": "GO:0055003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055003", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "face development", "id": "GO:0060324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060324", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "megakaryocyte development", "id": "GO:0035855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035855", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "dorsal aorta morphogenesis", "id": "GO:0035912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035912", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "response to hormone", "id": "GO:0009725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009725", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of axon extension", "id": "GO:0045773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045773", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "eyelid development in camera-type eye", "id": "GO:0061029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061029", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "bicellular tight junction assembly", "id": "GO:0070830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070830", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "mesoderm formation", "id": "GO:0001707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001707", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "long-term memory", "id": "GO:0007616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007616", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "platelet formation", "id": "GO:0030220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030220", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of filopodium assembly", "id": "GO:0051491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "heart trabecula formation", "id": "GO:0060347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060347", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cellular senescence", "id": "GO:0090398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090398", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "negative regulation of amyloid-beta clearance", "id": "GO:1900222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900222", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "stress fiber assembly", "id": "GO:0043149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043149", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "erythrocyte development", "id": "GO:0048821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "skin morphogenesis", "id": "GO:0043589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043589", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "epithelial structure maintenance", "id": "GO:0010669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010669", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "bronchus cartilage development", "id": "GO:0060532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060532", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "lung smooth muscle development", "id": "GO:0061145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061145", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive thymic T cell selection", "id": "GO:0045059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045059", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "angiogenesis involved in wound healing", "id": "GO:0060055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060055", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "regulation of smooth muscle cell differentiation", "id": "GO:0051150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051150", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "lung morphogenesis", "id": "GO:0060425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060425", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "positive regulation of miRNA transcription", "id": "GO:1902895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902895", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "primitive streak formation", "id": "GO:0090009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090009", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "epithelial cell-cell adhesion", "id": "GO:0090136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090136", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "morphogenesis of an epithelial sheet", "id": "GO:0002011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002011", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cardiac vascular smooth muscle cell differentiation", "id": "GO:0060947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060947", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "tangential migration from the subventricular zone to the olfactory bulb", "id": "GO:0022028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022028", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "serum response element binding", "id": "GO:0010736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010736", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "primary miRNA binding", "id": "GO:0070878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070878", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by PRKDC.", "evidence": [ { "database": "UniProtKB", "id": "P11831", "url": "https://www.uniprot.org/uniprot/P11831" }, { "database": "PubMed", "id": "8375385", "url": "https://glygen.org/publication/PubMed/8375385" }, { "database": "PubMed", "id": "8407951", "url": "https://glygen.org/publication/PubMed/8407951" }, { "database": "PubMed", "id": "1547771", "url": "https://glygen.org/publication/PubMed/1547771" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 36, 277, 288, 307, 309, 311, 313, 316, 383, 384, 385, 401, 460, 462, 463, 465, 471 ], "snv_sites": [ 36, 42, 245, 276, 309, 313, 324, 375, 385, 427, 503 ], "glycation_sites": [], "phosphorylation_sites": [ 71, 76, 77, 79, 83, 85, 103, 159, 160, 224, 228, 253, 435, 446 ], "sequon_annotation_sites": [ { "start_pos": 23, "end_pos": 25 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 490, "end_pos": 492 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 22 }, { "field": "total_sites", "count": 17 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 22 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 5 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 17 }, { "field": "total_sites", "count": 17 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 17 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 23 }, { "field": "total_sites", "count": 14 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 11 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 262 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }