{ "uniprot_canonical_ac": "P11597-1", "uniprot_ac": "P11597", "uniprot_id": "CETP_HUMAN", "mass": { "chemical_mass": 54756.0, "monoisotopic_mass": 54756.0 }, "refseq": { "ac": "NP_000069", "name": "cholesteryl ester transfer protein isoform 1 precursor", "summary": "The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" }, "gene_names": [ { "name": "CETP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11597", "id": "P11597" }, { "name": "BPIFF; HDLCQ10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069", "id": "NP_000069" }, { "name": "CETP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069", "id": "NP_000069" } ], "protein_names": [ { "name": "Cholesteryl ester transfer protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11597" }, { "name": "Lipid transfer protein I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11597" }, { "name": "cholesteryl ester transfer protein isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069", "id": "NP_000069" }, { "name": "lipid transfer protein I; BPI fold containing family F; cholesteryl ester transfer protein plasma", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069", "id": "NP_000069" } ], "function": [ { "annotation": "Association of dyslipidemia with single nucleotide polymorphisms of the cholesteryl ester transfer protein gene and cardiovascular disease risk factors in a highly admixed population.", "evidence": [ { "database": "RefSeq", "id": "NP_000069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" }, { "database": "PubMed", "id": "38057013", "url": "https://glygen.org/publication/PubMed/38057013" } ] }, { "annotation": "CETP and APOA2 polymorphisms are associated with weight loss and healthy eating behavior changes in response to digital lifestyle modifications. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" }, { "database": "PubMed", "id": "38062157", "url": "https://glygen.org/publication/PubMed/38062157" } ] }, { "annotation": "Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene.", "evidence": [ { "database": "RefSeq", "id": "NP_000069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" }, { "database": "PubMed", "id": "37929782", "url": "https://glygen.org/publication/PubMed/37929782" } ] }, { "annotation": "Interaction between CETP Taq1B polymorphism and dietary patterns on lipid profile and severity of coronary arteries stenosis in patients under coronary angiography: a cross-sectional study. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" }, { "database": "PubMed", "id": "38098040", "url": "https://glygen.org/publication/PubMed/38098040" } ] }, { "annotation": "Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.", "evidence": [ { "database": "UniProtKB", "id": "H3BRJ9", "url": "https://www.uniprot.org/uniprot/H3BRJ9#function" }, { "database": "UniProtKB", "id": "PIRNR037185", "url": "https://www.uniprot.org/uniprot/PIRNR037185#function" }, { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597#function" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" }, { "database": "PubMed", "id": "3600759", "url": "https://glygen.org/publication/PubMed/3600759" }, { "database": "PubMed", "id": "3281933", "url": "https://glygen.org/publication/PubMed/3281933" }, { "database": "PubMed", "id": "24293641", "url": "https://glygen.org/publication/PubMed/24293641" } ] }, { "annotation": "The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_000069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" } ] }, { "annotation": "Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000069" }, { "database": "PubMed", "id": "38039300", "url": "https://glygen.org/publication/PubMed/38039300" } ] } ], "disease": [ { "disease_id": "DOID:0111369", "recommended_name": { "id": "DOID:0111369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111369", "name": "hyperalphalipoproteinemia 1", "description": "A cholesterol-ester transfer protein deficiency characterized by elevated levels of alpha-lipoprotein in the blood that has_material_basis_in heterozygous mutation in the CETP gene on chromosome 16q13." }, "synonyms": [ { "id": "DOID:0111369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111369", "name": "HALP1", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "cholesterol-ester transfer protein deficiency", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "hyperalphalipoproteinemia", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "CEPT deficiency", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "familial hyperalphalipoproteinemia", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "high density lipoprotein cholesterol level QTL 10", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "hyperalphalipoproteinemia 1", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "hyperalphalipoproteinemia type 1", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "CETP deficiency", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "HALP1", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "Hdlcq10", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "cholesterol ester transfer Protein deficiency", "description": "" }, { "id": "MONDO:0007744", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007744", "name": "high density lipoprotein cholesterol level quantitative trait locus 10", "description": "" }, { "id": "MIM:143470", "resource": "MIM", "url": "https://www.omim.org/entry/143470", "name": "Hyperalphalipoproteinemia 1", "description": "Hyperalphalipoproteinemia 1" } ], "evidence": [ { "id": "143470", "database": "MIM", "url": "https://www.omim.org/entry/143470" } ] } ], "snv": [ { "evidence": [ { "id": "rs1567472893", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1567472893" }, { "id": "rs1567472893", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1567472893" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 266, "end_pos": 266, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "16", "chr_pos": "56973372", "ref_nt": "l", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T266", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1470772806", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1470772806" }, { "id": "rs1470772806", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1470772806#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 347, "end_pos": 347, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIS->NIS).", "chr_id": "16", "chr_pos": "56978150", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K347", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1012219073", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1012219073" }, { "id": "rs1012219073", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1012219073#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 358, "end_pos": 358, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NSS->KSS).", "chr_id": "16", "chr_pos": "56978183", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N358", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs190187567", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs190187567" }, { "id": "rs190187567", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs190187567" }, { "id": "rs190187567", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs190187567" }, { "id": "rs190187567", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs190187567#frequency_tab" }, { "id": "rs190187567", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs190187567" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 358, "end_pos": 358, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 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"start_pos": 215, "end_pos": 215, "sequence_org": "V", "sequence_mut": "W", "comment": "Reduces triglyceride transfer 10-fold. No effect on cholesteryl ester transfer.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 218, "end_pos": 218, "sequence_org": "R", "sequence_mut": "S", "comment": "Reduces triglyceride transfer 10-fold. Slight reduction of cholesteryl ester transfer.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 247, "end_pos": 247, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduces triglyceride transfer 5-fold. Slight reduction of cholesteryl ester transfer.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 282, "end_pos": 282, "sequence_org": "F", "sequence_mut": "R", "comment": "Not secreted.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 287, "end_pos": 287, "sequence_org": "F", "sequence_mut": "R", "comment": "Not secreted.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 309, "end_pos": 309, "sequence_org": "F", "sequence_mut": "D", "comment": "Not secreted.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 313, "end_pos": 313, "sequence_org": "L", "sequence_mut": "Q", "comment": "Reduces cholesteryl ester transfer by 60%.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 392, "end_pos": 392, "sequence_org": "Y", "sequence_mut": "S", "comment": "Not secreted.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 399, "end_pos": 399, "sequence_org": "L", "sequence_mut": "W", "comment": "Not secreted.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] }, { "start_pos": 433, "end_pos": 433, "sequence_org": "V", "sequence_mut": "R", "comment": "Reduces activity by 60%.", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" }, { "database": "PubMed", "id": "17237796", "url": "https://glygen.org/publication/PubMed/17237796" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "59.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000087237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087237" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": 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hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P11597", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11597" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P11597", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11597" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": 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"description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": 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"ENST00000200676.8", "url": "https://www.ensembl.org/id/ENST00000200676.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000200676.3", "url": "https://www.ensembl.org/id/ENSP00000200676.3" } ] } }, { "isoform_ac": "P11597-2", "url": "", "sequence": { "sequence": "MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS", "length": 433, "header": "sp|P11597-2|CETP_HUMAN Isoform 2 of Cholesteryl ester transfer protein OS=Homo sapiens OX=9606 GN=CETP PE=1 SV=2 CANONICAL=P11597-1" }, "locus": { "chromosome": "16", "start_pos": 56983663, "end_pos": 56961980, "strand": "-", "evidence": [ { "database": "Ensembl 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Genet.", "date": "2003", "authors": "Morabia A, Cayanis E, Costanza MC, Ross BM, Flaherty MS, Alvin GB, Das K, Gilliam TC", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" } ], "reference": [ { "type": "PubMed", "id": "12966036", "url": "https://glygen.org/publication/PubMed/12966036" } ] }, { "title": "Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Oram JF, Wolfbauer G, Vaughan AM, Tang C, Albers JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964058" } ], "reference": [ { "type": "PubMed", "id": "14559902", "url": "https://glygen.org/publication/PubMed/14559902" } ] }, { "title": "Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of 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"https://glygen.org/publication/PubMed/8408659" } ] }, { "title": "Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice.", "journal": "J. Biol. Chem.", "date": "1996", "authors": "Oliveira H C, Chouinard R A, Agellon L B, Bruce C, Ma L, Walsh A, Breslow J L, Tall A R", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" } ], "reference": [ { "type": "PubMed", "id": "8943225", "url": "https://glygen.org/publication/PubMed/8943225" } ] }, { "title": "Sequencing of the cholesteryl ester transfer protein 5' regulatory region using artificial transposons.", "journal": "Gene", "date": "1997", "authors": "Williams S, Hayes L, Elsenboss L, Williams A, Andre C, Abramson R, Thompson J F, Milos P M", "evidence": [ { "database": "UniProtKB", "id": "P11597", "url": "https://www.uniprot.org/uniprot/P11597" } ], "reference": [ { "type": "PubMed", "id": "9332354", "url": "https://glygen.org/publication/PubMed/9332354" } ] }, { "title": "Intracellular metabolism of human apolipoprotein(a) in stably transfected Hep G2 cells.", "journal": "Biochemistry", "date": "1998", "authors": "Lobentanz 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biological chemistry", "date": "1999", "authors": "Wang X, Driscoll DM, Morton RE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041" } ], "reference": [ { "type": "PubMed", "id": "9880564", "url": "https://glygen.org/publication/PubMed/9880564" } ] } ], "pathway": [ { "id": "hsa:1071", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1071", "resource": "KEGG Pathway" }, { "id": "R-HSA-8964041", "name": "LDL remodeling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041", "resource": "Reactome", "description": "LDL remodeling" }, { "id": "R-HSA-8964058", "name": "HDL remodeling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964058", "resource": "Reactome", "description": "HDL remodeling" }, { "id": "R-HSA-9029569", "name": "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "url": 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