{
"uniprot_canonical_ac": "P11274-1",
"uniprot_ac": "P11274",
"uniprot_id": "BCR_HUMAN",
"mass": {
"chemical_mass": 142819.0,
"monoisotopic_mass": 142819.0
},
"refseq": {
"ac": "NP_004318",
"name": "breakpoint cluster region protein isoform 1",
"summary": "A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
},
"gene_names": [
{
"name": "BCR",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P11274",
"id": "P11274"
},
{
"name": "ALL; BCR1; CML; D22S11; D22S662; PHL",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318",
"id": "NP_004318"
},
{
"name": "BCR1",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P11274",
"id": "P11274"
},
{
"name": "BCR",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318",
"id": "NP_004318"
},
{
"name": "D22S11",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P11274",
"id": "P11274"
}
],
"protein_names": [
{
"name": "Breakpoint cluster region protein",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P11274"
},
{
"name": "2.7.11.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11274"
},
{
"name": "Renal carcinoma antigen NY-REN-26",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11274"
},
{
"name": "breakpoint cluster region protein isoform 1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318",
"id": "NP_004318"
},
{
"name": "renal carcinoma antigen NY-REN-26; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; BCR, RhoGEF and GTPase activating protein; breakpoint cluster region",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318",
"id": "NP_004318"
}
],
"function": [
{
"annotation": "A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
}
]
},
{
"annotation": "Deep sequencing reveals the spectrum of BCR-ABL1 mutations upon front-line therapy resistance in chronic myeloid leukemia: An Eastern-Indian cohort study.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
},
{
"database": "PubMed",
"id": "36155130",
"url": "https://glygen.org/publication/PubMed/36155130"
}
]
},
{
"annotation": "Emergence of a BCR::ABL1 rearrangement following a uniquely complex clonal evolution pattern in a patient undergoing Fms-like tyrosine kinase 3 inhibitor therapy for acute myeloid leukemia.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
},
{
"database": "PubMed",
"id": "36180046",
"url": "https://glygen.org/publication/PubMed/36180046"
}
]
},
{
"annotation": "Histone demethylase PHF8 facilitates the development of chronic myeloid leukaemia by directly targeting BCR::ABL1.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
},
{
"database": "PubMed",
"id": "37469124",
"url": "https://glygen.org/publication/PubMed/37469124"
}
]
},
{
"annotation": "Prevalence of BCR-ABL T315I Mutation in Different Chronic Myeloid Leukemia patients Categories.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
},
{
"database": "PubMed",
"id": "35234007",
"url": "https://glygen.org/publication/PubMed/35234007"
}
]
},
{
"annotation": "Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119).",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274#function"
},
{
"database": "PubMed",
"id": "1903516",
"url": "https://glygen.org/publication/PubMed/1903516"
},
{
"database": "UniProtKB",
"id": "Q6PAJ1",
"url": "https://www.uniprot.org/uniprot/Q6PAJ1#function"
},
{
"database": "PubMed",
"id": "23940119",
"url": "https://glygen.org/publication/PubMed/23940119"
},
{
"database": "PubMed",
"id": "17116687",
"url": "https://glygen.org/publication/PubMed/17116687"
},
{
"database": "PubMed",
"id": "7479768",
"url": "https://glygen.org/publication/PubMed/7479768"
},
{
"database": "PubMed",
"id": "1657398",
"url": "https://glygen.org/publication/PubMed/1657398"
}
]
},
{
"annotation": "The interplay between telomeric complex members and BCR::ABL1 oncogenic tyrosine kinase in the maintenance of telomere length in chronic myeloid leukemia.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
},
{
"database": "PubMed",
"id": "36871092",
"url": "https://glygen.org/publication/PubMed/36871092"
}
]
}
],
"disease": [
{
"disease_id": "DOID:8552",
"recommended_name": {
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "chronic myeloid leukemia",
"description": "A myeloid leukemia that is characterized by over production of white blood cells."
},
"synonyms": [
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "CML",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "CML - chronic Myelogenous Leukemia",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "Myeloid Leukemia, chronic",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "chronic granulocytic leukaemia",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "chronic granulocytic leukemia",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "chronic myelogenous leukaemia",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "chronic myelogenous leukemia",
"description": ""
},
{
"id": "DOID:8552",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:8552",
"name": "chronic myeloid leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukemia, BCR-ABL1 positive",
"description": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival."
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "BCR-ABL Positive chronic myelogenous leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "BCR-ABL Positive chronic myelogenous leukemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "CML",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "CML - chronic myelogenous leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "CML - chronic myelogenous leukemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic granulocytic leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic granulocytic leukemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelocytic leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelocytic leukemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukaemia (CML)",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukemia (CML)",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukemia, BCR-ABL1 Positive",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myelogenous leukemias",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myeloid leukaemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "chronic myeloid leukemia",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "hematopoeitic - chronic myelocytic leukaemia (CML)",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "hematopoeitic - chronic myelocytic leukemia (CML)",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "leukemia, chronic myeloid, Philadelphia chromosome positive, somatic",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "myeloid leukemia, chronic",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "leukemia, chronic myelogenous",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "leukemia, chronic myeloid",
"description": ""
},
{
"id": "MONDO:0011996",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011996",
"name": "leukemia, chronic myeloid, atypical",
"description": ""
},
{
"id": "MIM:608232",
"resource": "MIM",
"url": "https://www.omim.org/entry/608232",
"name": "Leukemia, chronic myeloid, atypical",
"description": "Leukemia, chronic myeloid, atypical"
}
],
"evidence": [
{
"id": "608232",
"database": "MIM",
"url": "https://www.omim.org/entry/608232"
}
]
}
],
"snv": [
{
"evidence": [
{
"id": "rs747669084",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747669084"
},
{
"id": "rs747669084",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747669084"
},
{
"id": "rs747669084",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs747669084"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1025,
"end_pos": 1025,
"sequence_org": "I",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGI->NGS).",
"chr_id": "22",
"chr_pos": "23310325",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "I1025",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1323699916",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1323699916"
},
{
"id": "rs1323699916",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1323699916#frequency_tab"
},
{
"id": "rs1323699916",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1323699916"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1111,
"end_pos": 1111,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DVS->NVS).",
"chr_id": "22",
"chr_pos": "23312895",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D1111",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs200099830",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200099830"
},
{
"id": "rs200099830",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs200099830"
},
{
"id": "rs200099830",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200099830"
},
{
"id": "rs200099830",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs200099830#frequency_tab"
},
{
"id": "rs200099830",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs200099830"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1149,
"end_pos": 1149,
"sequence_org": "A",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFA->NFS).",
"chr_id": "22",
"chr_pos": "23313009",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "0.001597",
"site_lbl": "A1149",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs200099830",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200099830"
},
{
"id": "rs200099830",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs200099830"
},
{
"id": "rs200099830",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200099830"
},
{
"id": "rs200099830",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs200099830#frequency_tab"
},
{
"id": "rs200099830",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs200099830"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1149,
"end_pos": 1149,
"sequence_org": "A",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFA->NFT).",
"chr_id": "22",
"chr_pos": "23313009",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "0.001597",
"site_lbl": "A1149",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P11274",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11274"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 1197,
"end_pos": 1197,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KMS->NMS).",
"chr_id": "22",
"chr_pos": "23314579",
"ref_nt": "G",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "K1197",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
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"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
],
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},
{
"evidence": [
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},
{
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},
{
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}
],
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"sequence_mut": "N",
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},
{
"evidence": [
{
"id": "rs868145350",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs868145350"
},
{
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"url": "https://www.ncbi.nlm.nih.gov/snp/rs868145350#frequency_tab"
},
{
"id": "rs868145350",
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}
],
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],
"start_pos": 777,
"end_pos": 777,
"sequence_org": "P",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIP->NIS).",
"chr_id": "22",
"chr_pos": "23285124",
"ref_nt": "T",
"alt_nt": "null",
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"site_lbl": "P777",
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]
},
{
"evidence": [
{
"id": "rs774451417",
"database": "dbSNP",
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},
{
"id": "rs774451417",
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"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774451417"
},
{
"id": "rs774451417",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs774451417"
}
],
"glycoeffect": [
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"o-glyco-site-loss"
],
"start_pos": 790,
"end_pos": 790,
"sequence_org": "K",
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"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIS->NIS).",
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},
{
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},
{
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"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs781152622"
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],
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],
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"end_pos": 798,
"sequence_org": "I",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDI->NDT).",
"chr_id": "22",
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"ref_nt": "C",
"alt_nt": "null",
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"site_lbl": "I798",
"keywords": [
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"germline"
]
},
{
"evidence": [
{
"id": "rs917192247",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs917192247"
},
{
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],
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},
{
"evidence": [
{
"id": "rs1602108762",
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},
{
"id": "rs1602108762",
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],
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"o-glyco-site-loss"
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"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SFS->NFS).",
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"germline"
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},
{
"evidence": [
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},
{
"id": "rs760174921",
"database": "ExAC",
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},
{
"id": "rs760174921",
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}
],
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"o-glyco-site-loss"
],
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"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TNS->NNS).",
"chr_id": "22",
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"germline"
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},
{
"evidence": [
{
"id": "P11274",
"database": "BioMuta",
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},
{
"id": "rs1456120080",
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{
"id": "rs1456120080",
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"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1456120080"
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{
"id": "rs1456120080",
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],
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],
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"subjects_tested": "0",
"subjects_positive": "0",
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{
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"resource": "Disease Ontology",
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{
"id": "DOID:1612",
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"url": "http://disease-ontology.org/term/DOID:1612",
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{
"id": "DOID:1612",
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},
{
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"resource": "Disease Ontology",
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{
"id": "DOID:1612",
"resource": "Disease Ontology",
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},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
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"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
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"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
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},
{
"id": "MIM:114480",
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]
}
],
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],
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{
"disease_id": "DOID:1324",
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0012955",
"resource": "MONDO",
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},
{
"id": "MONDO:0012955",
"resource": "MONDO",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
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"name": "lung cancer susceptibility 5",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
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"name": "lung cancer susceptibility 5",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "malignant neoplasm of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MIM:211980",
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}
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}
],
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"evidence": [
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{
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]
},
{
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{
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]
},
{
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{
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]
},
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{
"database": "PubMed",
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"url": "https://glygen.org/publication/PubMed/15494376"
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{
"database": "PubMed",
"id": "20962234",
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]
},
{
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"database": "UniProtKB",
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{
"database": "PubMed",
"id": "15302586",
"url": "https://glygen.org/publication/PubMed/15302586"
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{
"database": "PubMed",
"id": "9407116",
"url": "https://glygen.org/publication/PubMed/9407116"
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]
},
{
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"comment": "Loss of RHOAGEF activity.",
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{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
},
{
"database": "PubMed",
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"url": "https://glygen.org/publication/PubMed/23940119"
}
]
}
],
"expression_tissue": [
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"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
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"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
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]
},
{
"tissue": {
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"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
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"score": "83.98",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
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]
},
{
"tissue": {
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"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
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"present": "HIGH",
"evidence": [
{
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"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
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]
},
{
"tissue": {
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
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"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "90.31",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
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]
},
{
"tissue": {
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"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "83.02",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "77.41",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "83.51",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "91.87",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "78.13",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "86.4",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "89.36",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "89.84",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000186716",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000186716"
}
]
}
],
"expression_disease": [
{
"significant": "No",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
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}
],
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{
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
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"synonyms": [
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"name": "gastric cancer",
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},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
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{
"database": "BioXpress",
"id": "P11274",
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},
"synonyms": [
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},
{
"id": "DOID:11054",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of the bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of the urinary bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant neoplasm, bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant tumour of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
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},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
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{
"database": "BioXpress",
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],
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{
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
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{
"database": "BioXpress",
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"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
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],
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{
"disease_id": "DOID:1324",
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"synonyms": [
{
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"resource": "MONDO",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
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},
{
"id": "MONDO:0012159",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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"name": "LNCR3",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "lung cancer, somatic",
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},
{
"id": "MONDO:0008903",
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"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
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},
{
"id": "MONDO:0008903",
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"name": "malignant neoplasm of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P11274",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11274"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
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"categories": [
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]
},
{
"id": "NX_P11274",
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]
},
{
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]
},
{
"id": "P11274",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11274",
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]
},
{
"id": "IKVKISH",
"url": "https://omabrowser.org/oma/group/IKVKISH/",
"database": "OMA",
"categories": [
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]
},
{
"id": "2916231at2759",
"url": "http://www.orthodb.org/?query=2916231at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR23182",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23182",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR23182:SF3",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23182:SF3",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "1K1F",
"url": "https://www.rcsb.org/structure/1K1F",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2AIN",
"url": "https://www.rcsb.org/structure/2AIN",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5N6R",
"url": "https://www.rcsb.org/structure/5N6R",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5N7E",
"url": "https://www.rcsb.org/structure/5N7E",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5OC7",
"url": "https://www.rcsb.org/structure/5OC7",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00168",
"url": "http://pfam.xfam.org/family/PF00168",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00620",
"url": "http://pfam.xfam.org/family/PF00620",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00621",
"url": "http://pfam.xfam.org/family/PF00621",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF09036",
"url": "http://pfam.xfam.org/family/PF09036",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF19057",
"url": "http://pfam.xfam.org/family/PF19057",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "P11274",
"url": "https://pharos.nih.gov/targets/P11274",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR_P11274",
"url": "http://purl.obolibrary.org/obo/PR_P11274",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-1839117",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839117",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5655302",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655302",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013026",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013026",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013106",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013404",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013404",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013423",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013423",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "17989",
"url": "https://www.rhea-db.org/rhea/17989",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "46608",
"url": "https://www.rhea-db.org/rhea/46608",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "H0Y554",
"url": "https://www.uniprot.org/uniprot/H0Y554",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0Y554-1",
"url": "https://www.uniprot.org/uniprot/H0Y554-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P11274-1",
"url": "https://www.uniprot.org/uniprot/P11274-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P11274-2",
"url": "https://www.uniprot.org/uniprot/P11274-2",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV",
"length": 1271,
"header": "sp|P11274-1|BCR_HUMAN Isoform 1 of Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2 CANONICAL=P11274-1"
},
"isoforms": [
{
"isoform_ac": "H0Y554-1",
"url": "",
"sequence": {
"sequence": "ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLNLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAV",
"length": 257,
"header": "tr|H0Y554-1|H0Y554_HUMAN Computationally mapped isoform of BCR activator of RhoGEF and GTPase OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=1 CANONICAL=P11274-1"
},
"locus": {
"chromosome": "22",
"start_pos": 23285114,
"end_pos": 23253960,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000427791.1",
"url": "https://www.ensembl.org/id/ENST00000427791.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000396531.1",
"url": "https://www.ensembl.org/id/ENSP00000396531.1"
}
]
}
},
{
"isoform_ac": "P11274-1",
"url": "",
"sequence": {
"sequence": "MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV",
"length": 1271,
"header": "sp|P11274-1|BCR_HUMAN Isoform 1 of Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2 CANONICAL=P11274-1"
},
"locus": {
"chromosome": "22",
"start_pos": 23315519,
"end_pos": 23180961,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000305877.13",
"url": "https://www.ensembl.org/id/ENST00000305877.13"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000303507.8",
"url": "https://www.ensembl.org/id/ENSP00000303507.8"
}
]
}
},
{
"isoform_ac": "P11274-2",
"url": "",
"sequence": {
"sequence": "MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV",
"length": 1227,
"header": "sp|P11274-2|BCR_HUMAN Isoform 2 of Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2 CANONICAL=P11274-1"
},
"locus": {
"chromosome": "22",
"start_pos": 23315519,
"end_pos": 23180961,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000359540.7",
"url": "https://www.ensembl.org/id/ENST00000359540.7"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000352535.3",
"url": "https://www.ensembl.org/id/ENSP00000352535.3"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 400,
"start_aa": "Ser",
"end_pos": 400,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser400",
"evidence": [
{
"id": "P11274",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11274"
},
{
"id": "37217939",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/37217939"
},
{
"id": "28657654",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/28657654"
},
{
"id": "P11274",
"database": "O-GlcNAc Atlas",
"url": "https://oglcnac.org/atlas/detail/P11274"
}
]
}
],
"phosphorylation": [
{
"start_pos": 122,
"end_pos": 122,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "PubMed",
"id": "21406692",
"url": "https://glygen.org/publication/PubMed/21406692"
},
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
},
{
"database": "PubMed",
"id": "19664994",
"url": "https://glygen.org/publication/PubMed/19664994"
},
{
"database": "PubMed",
"id": "20230923",
"url": "https://glygen.org/publication/PubMed/20230923"
},
{
"database": "phospho.ELM",
"id": "P11274",
"url": "http://phospho.elm.eu.org/byAccession/P11274.html"
},
{
"database": "PubMed",
"id": "18220336",
"url": "https://glygen.org/publication/PubMed/18220336"
}
],
"site_lbl": "Ser122"
},
{
"start_pos": 1264,
"end_pos": 1264,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
},
{
"database": "PubMed",
"id": "15144186",
"url": "https://glygen.org/publication/PubMed/15144186"
},
{
"database": "PubMed",
"id": "19690332",
"url": "https://glygen.org/publication/PubMed/19690332"
},
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
},
{
"database": "PubMed",
"id": "19664994",
"url": "https://glygen.org/publication/PubMed/19664994"
},
{
"database": "phospho.ELM",
"id": "P11274",
"url": "http://phospho.elm.eu.org/byAccession/P11274.html"
},
{
"database": "PubMed",
"id": "11084041",
"url": "https://glygen.org/publication/PubMed/11084041"
}
],
"site_lbl": "Ser1264"
},
{
"start_pos": 139,
"end_pos": 139,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
}
],
"site_lbl": "Ser139"
},
{
"start_pos": 177,
"end_pos": 177,
"kinase_uniprot_canonical_ac": "P07332-1",
"kinase_gene_name": "FES",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
},
{
"database": "PubMed",
"id": "8955135",
"url": "https://glygen.org/publication/PubMed/8955135"
},
{
"database": "PubMed",
"id": "9178913",
"url": "https://glygen.org/publication/PubMed/9178913"
},
{
"database": "PubMed",
"id": "9407116",
"url": "https://glygen.org/publication/PubMed/9407116"
},
{
"database": "PubMed",
"id": "15302586",
"url": "https://glygen.org/publication/PubMed/15302586"
},
{
"database": "phospho.ELM",
"id": "P11274",
"url": "http://phospho.elm.eu.org/byAccession/P11274.html"
},
{
"database": "PubMed",
"id": "10405761",
"url": "https://glygen.org/publication/PubMed/10405761"
}
],
"site_lbl": "Tyr177"
},
{
"start_pos": 177,
"end_pos": 177,
"kinase_uniprot_canonical_ac": "P08631-1",
"kinase_gene_name": "HCK",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
},
{
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{
"title": "Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2016",
"authors": "Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, Murakami M",
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"id": "27630163",
"url": "https://glygen.org/publication/PubMed/27630163"
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]
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"title": "Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.",
"journal": "Scientific reports",
"date": "2016",
"authors": "Zamboni V, Armentano M, Saro G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR",
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{
"type": "PubMed",
"id": "27713499",
"url": "https://glygen.org/publication/PubMed/27713499"
}
]
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{
"title": "Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.",
"journal": "Nature immunology",
"date": "2016",
"authors": "Martins R, Maier J, Gorki AD, Huber KV, Sharif O, Starkl P, Saluzzo S, Quattrone F, Gawish R, Lakovits K, Aichinger MC, Radic-Sarikas B, Lardeau CH, Hladik A, Korosec A, Brown M, Vaahtomeri K, Duggan M, Kerjaschki D, Esterbauer H, Colinge J, Eisenbarth SC, Decker T, Bennett KL, Kubicek S, Sixt M, Superti-Furga G, Knapp S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148"
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"reference": [
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"type": "PubMed",
"id": "27798618",
"url": "https://glygen.org/publication/PubMed/27798618"
}
]
},
{
"title": "SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis.",
"journal": "Cell reports",
"date": "2016",
"authors": "Baranov MV, Revelo NH, Dingjan I, Maraspini R, Ter Beest M, Honigmann A, van den Bogaart G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149"
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"reference": [
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"type": "PubMed",
"id": "27806292",
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]
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"title": "SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2017",
"authors": "Toffali L, Montresor A, Mirenda M, Scita G, Laudanna C",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
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],
"reference": [
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"type": "PubMed",
"id": "27986909",
"url": "https://glygen.org/publication/PubMed/27986909"
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]
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{
"title": "LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.",
"journal": "The Journal of experimental medicine",
"date": "2017",
"authors": "Xu X, Han L, Zhao G, Xue S, Gao Y, Xiao J, Zhang S, Chen P, Wu ZY, Ding J, Hu R, Wei B, Wang H",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148"
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],
"reference": [
{
"type": "PubMed",
"id": "28028151",
"url": "https://glygen.org/publication/PubMed/28028151"
}
]
},
{
"title": "Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.",
"journal": "The Journal of clinical investigation",
"date": "2017",
"authors": "Bai X, Mangum KD, Dee RA, Stouffer GA, Lee CR, Oni-Orisan A, Patterson C, Schisler JC, Viera AJ, Taylor JM, Mack CP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
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"reference": [
{
"type": "PubMed",
"id": "28112683",
"url": "https://glygen.org/publication/PubMed/28112683"
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]
},
{
"title": "RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development.",
"journal": "PloS one",
"date": "2017",
"authors": "Martin-Vilchez S, Whitmore L, Asmussen H, Zareno J, Horwitz R, Newell-Litwa K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149"
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],
"reference": [
{
"type": "PubMed",
"id": "28114311",
"url": "https://glygen.org/publication/PubMed/28114311"
}
]
},
{
"title": "Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering.",
"journal": "The Biochemical journal",
"date": "2017",
"authors": "Peurois F, Veyron S, Ferrandez Y, Ladid I, Benabdi S, Zeghouf M, Peyroche G, Cherfils J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
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],
"reference": [
{
"type": "PubMed",
"id": "28196833",
"url": "https://glygen.org/publication/PubMed/28196833"
}
]
},
{
"title": "A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.",
"journal": "Nature",
"date": "1987",
"authors": "Fainstein E, Marcelle C, Rosner A, Canaani E, Gale RP, Dreazen O, Smith SD, Croce CM",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
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],
"reference": [
{
"type": "PubMed",
"id": "2825022",
"url": "https://glygen.org/publication/PubMed/2825022"
}
]
},
{
"title": "Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.",
"journal": "Molecular biology of the cell",
"date": "2017",
"authors": "Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013423",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013423"
}
],
"reference": [
{
"type": "PubMed",
"id": "28356423",
"url": "https://glygen.org/publication/PubMed/28356423"
}
]
},
{
"title": "ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility.",
"journal": "Journal of cell science",
"date": "2017",
"authors": "Luo W, Janostiak R, Tolde O, Ryzhova LM, Koudelkova L, Dibus M, Brabek J, Hanks SK, Rosel D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
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],
"reference": [
{
"type": "PubMed",
"id": "28584191",
"url": "https://glygen.org/publication/PubMed/28584191"
}
]
},
{
"title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.",
"journal": "The Journal of pathology",
"date": "2017",
"authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "P11274",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11274"
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"database": "O-GlcNAc Atlas",
"id": "P11274",
"url": "https://oglcnac.org/atlas/detail/P11274"
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"reference": [
{
"type": "PubMed",
"id": "28657654",
"url": "https://glygen.org/publication/PubMed/28657654"
}
]
},
{
"title": "An apical MRCK-driven morphogenetic pathway controls epithelial polarity.",
"journal": "Nature cell biology",
"date": "2017",
"authors": "Zihni C, Vlassaks E, Terry S, Carlton J, Leung TKC, Olson M, Pichaud F, Balda MS, Matter K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148"
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"reference": [
{
"type": "PubMed",
"id": "28825699",
"url": "https://glygen.org/publication/PubMed/28825699"
}
]
},
{
"title": "A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.",
"journal": "Scientific reports",
"date": "2017",
"authors": "Amado-Azevedo J, Reinhard NR, van Bezu J, de Menezes RX, van Beusechem VW, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148"
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],
"reference": [
{
"type": "PubMed",
"id": "28860633",
"url": "https://glygen.org/publication/PubMed/28860633"
}
]
},
{
"title": "Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.",
"journal": "Scientific reports",
"date": "2017",
"authors": "Ferrandez Y, Zhang W, Peurois F, Akendengue L, Blangy A, Zeghouf M, Cherfils J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149"
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"reference": [
{
"type": "PubMed",
"id": "29089502",
"url": "https://glygen.org/publication/PubMed/29089502"
}
]
},
{
"title": "Cytokinesis requires localized beta-actin filament production by an actin isoform specific nucleator.",
"journal": "Nature communications",
"date": "2017",
"authors": "Chen A, Arora PD, McCulloch CA, Wilde A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
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"reference": [
{
"type": "PubMed",
"id": "29146911",
"url": "https://glygen.org/publication/PubMed/29146911"
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]
},
{
"title": "Alternative 5' end of the bcr-abl transcript in chronic myelogenous leukemia.",
"journal": "Oncogene",
"date": "1989",
"authors": "Romero P, Beran M, Shtalrid M, Andersson B, Talpaz M, Blick M",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
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],
"reference": [
{
"type": "PubMed",
"id": "2915904",
"url": "https://glygen.org/publication/PubMed/2915904"
}
]
},
{
"title": "Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.",
"journal": "The Journal of biological chemistry",
"date": "2018",
"authors": "Ozdemir ES, Jang H, Gursoy A, Keskin O, Li Z, Sacks DB, Nussinov R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149"
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],
"reference": [
{
"type": "PubMed",
"id": "29358323",
"url": "https://glygen.org/publication/PubMed/29358323"
}
]
},
{
"title": "ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients.",
"journal": "Laboratory investigation; a journal of technical methods and pathology",
"date": "2018",
"authors": "Zhou H, Cai L, Zhang X, Li A, Miao Y, Li Q, Qiu X, Wang E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149"
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],
"reference": [
{
"type": "PubMed",
"id": "29382922",
"url": "https://glygen.org/publication/PubMed/29382922"
}
]
},
{
"title": "Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer.",
"journal": "EMBO molecular medicine",
"date": "2018",
"authors": "Jeitany M, Leroy C, Tosti P, Lafitte M, Le Guet J, Simon V, Bonenfant D, Robert B, Grillet F, Mollevi C, El Messaoudi S, Otandault A, Canterel-Thouennon L, Busson M, Thierry AR, Martineau P, Pannequin J, Roche S, Sirvent A",
"evidence": [
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
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{
"type": "PubMed",
"id": "29438985",
"url": "https://glygen.org/publication/PubMed/29438985"
}
]
},
{
"title": "Structural organization of the bcr gene and its role in the Ph' translocation.",
"journal": "Nature",
"date": "1985",
"authors": "Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
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{
"type": "PubMed",
"id": "2989703",
"url": "https://glygen.org/publication/PubMed/2989703"
}
]
},
{
"title": "FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.",
"journal": "Nature cell biology",
"date": "2018",
"authors": "Chan Wah Hak L, Khan S, Di Meglio I, Law AL, Lucken-Ardjomande Hasler S, Quintaneiro LM, Ferreira APA, Krause M, McMahon HT, Boucrot E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148"
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],
"reference": [
{
"type": "PubMed",
"id": "30061681",
"url": "https://glygen.org/publication/PubMed/30061681"
}
]
},
{
"title": "Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.",
"journal": "Structure (London, England : 1993)",
"date": "2019",
"authors": "Kukimoto-Niino M, Tsuda K, Ihara K, Mishima-Tsumagari C, Honda K, Ohsawa N, Shirouzu M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013149",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149"
}
],
"reference": [
{
"type": "PubMed",
"id": "30853411",
"url": "https://glygen.org/publication/PubMed/30853411"
}
]
},
{
"title": "cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.",
"journal": "EMBO J.",
"date": "1987",
"authors": "Hariharan I K, Adams J M",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"reference": [
{
"type": "PubMed",
"id": "3107980",
"url": "https://glygen.org/publication/PubMed/3107980"
}
]
},
{
"title": "Anillin Promotes Cell Contractility by Cyclic Resetting of RhoA Residence Kinetics.",
"journal": "Developmental cell",
"date": "2019",
"authors": "Budnar S, Husain KB, Gomez GA, Naghibosadat M, Varma A, Verma S, Hamilton NA, Morris RG, Yap AS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
}
],
"reference": [
{
"type": "PubMed",
"id": "31105010",
"url": "https://glygen.org/publication/PubMed/31105010"
}
]
},
{
"title": "Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.",
"journal": "Cancer medicine",
"date": "2019",
"authors": "Zhang X, Fang J, Chen S, Wang W, Meng S, Liu B",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013404",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013404"
}
],
"reference": [
{
"type": "PubMed",
"id": "31389670",
"url": "https://glygen.org/publication/PubMed/31389670"
}
]
},
{
"title": "Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.",
"journal": "Nature cell biology",
"date": "2020",
"authors": "Bagci H, Sriskandarajah N, Robert A, Boulais J, Elkholi IE, Tran V, Lin ZY, Thibault MP, Dube N, Faubert D, Hipfner DR, Gingras AC, Cote JF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9013148",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148"
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],
"reference": [
{
"type": "PubMed",
"id": "31871319",
"url": "https://glygen.org/publication/PubMed/31871319"
}
]
},
{
"title": "Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.",
"journal": "Nature cell biology",
"date": "2020",
"authors": "Muller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L, Czajkowski MT, Welke RW, Zhang S, Nguyen V, Rrustemi T, Trnka P, Freitag K, Larsen B, Popp O, Mertins P, Gingras AC, Roth FP, Colwill K, Bakal C, Pertz O, Pawson T, Petsalaki E, Rocks O",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692"
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],
"reference": [
{
"type": "PubMed",
"id": "32203420",
"url": "https://glygen.org/publication/PubMed/32203420"
}
]
},
{
"title": "bcr genes and transcripts.",
"journal": "Oncogene",
"date": "1988",
"authors": "Lifshitz B, Fainstein E, Marcelle C, Shtivelman E, Amson R, Gale R P, Canaani E",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
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"reference": [
{
"type": "PubMed",
"id": "3285291",
"url": "https://glygen.org/publication/PubMed/3285291"
}
]
},
{
"title": "Shikonin overcomes drug resistance and induces necroptosis by regulating the miR-92a-1-5p/MLKL axis in chronic myeloid leukemia.",
"journal": "Aging",
"date": "2020-09-14",
"authors": "Huang Xianbo, Chen Zhenzhen, Ni Fan, Ye Xiujin, Qian Wenbin",
"evidence": [
{
"database": "iPTMnet",
"id": "P11274",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11274"
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"reference": [
{
"type": "PubMed",
"id": "32927433",
"url": "https://glygen.org/publication/PubMed/32927433"
}
]
},
{
"title": "Prevalence of BCR-ABL T315I Mutation in Different Chronic Myeloid Leukemia patients Categories.",
"journal": "Pakistan journal of biological sciences : PJBS",
"date": "2022",
"authors": "Elsir Khair H, Ahmed Mohamed B, Yousef Nour B, Ali Waggiallah H",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
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],
"reference": [
{
"type": "PubMed",
"id": "35234007",
"url": "https://glygen.org/publication/PubMed/35234007"
}
]
},
{
"title": "Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "1986",
"authors": "Mes-Masson A M, McLaughlin J, Daley G Q, Paskind M, Witte O N",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
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"reference": [
{
"type": "PubMed",
"id": "3540951",
"url": "https://glygen.org/publication/PubMed/3540951"
}
]
},
{
"title": "Deep sequencing reveals the spectrum of BCR-ABL1 mutations upon front-line therapy resistance in chronic myeloid leukemia: An Eastern-Indian cohort study.",
"journal": "Cancer treatment and research communications",
"date": "2022",
"authors": "Dey Samya, Basu Soumi, Shah Shahena, Bhattacharyya Debmalya, Gupta Partha Pratim, Acharjee Mahasweta, Roychoudhury Susanta, Nath Somsubhra",
"evidence": [
{
"database": "RefSeq",
"id": "NP_004318",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_004318"
}
],
"reference": [
{
"type": "PubMed",
"id": "36155130",
"url": "https://glygen.org/publication/PubMed/36155130"
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]
},
{
"title": "Emergence of a BCR::ABL1 rearrangement following a uniquely complex clonal evolution pattern in a patient undergoing Fms-like tyrosine kinase 3 inhibitor therapy for acute myeloid leukemia.",
"journal": "International journal of laboratory hematology",
"date": "2022-09-30",
"authors": "Park Bosung, Kim Jiyeon, Kim Miyoung, Cho Young-Uk, Hwang Sang-Hyun, Jang Seongsoo, Seo Eul-Ju, Choi Eun-Ji, Park Chan-Jeoung",
"evidence": [
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"resource": "Reactome",
"description": "RHOC GTPase cycle"
},
{
"id": "R-HSA-9013148",
"name": "CDC42 GTPase cycle",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148",
"resource": "Reactome",
"description": "CDC42 GTPase cycle"
},
{
"id": "R-HSA-9013149",
"name": "RAC1 GTPase cycle",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149",
"resource": "Reactome",
"description": "RAC1 GTPase cycle"
},
{
"id": "R-HSA-9013404",
"name": "RAC2 GTPase cycle",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013404",
"resource": "Reactome",
"description": "RAC2 GTPase cycle"
},
{
"id": "R-HSA-9013423",
"name": "RAC3 GTPase cycle",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013423",
"resource": "Reactome",
"description": "RAC3 GTPase cycle"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "F1LXF1-1",
"protein_name": "Breakpoint cluster region protein",
"gene_name": "Bcr",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MVDSVGFAEAWRAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQPPDGAAEPRASAPRLPPAPADGADPAPVEESEARPDGEGSPSKGRPATARRPAAAAPADRDDRGPPTSVAALRSNFEKIRKGPAQPGSADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQQSAGQGLGEAPRPHYRGRSSESSCGLDGDYEDAELNPRFLKDNLINANGGNRPPWPPLEYQPYQSIYVGGMMVEGEGKSPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQKRHRQCQVVVSEATIVGVRKTGQIWPSDGDSTFQGEADSSFGTPPGYGCAADQAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSPASGALEPTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGFLHAIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCYEKCYNKMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSVKFTSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV",
"length": 1270
},
"evidence": [
{
"id": "P11274",
"url": "https://omabrowser.org/oma/group/P11274/",
"database": "OMA"
}
],
"common_name": "Rat"
},
{
"uniprot_canonical_ac": "Q6PAJ1-1",
"protein_name": "Breakpoint cluster region protein",
"gene_name": "Bcr",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MVDSVGFAEAWRAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQPPDGAAEPRASAPRPPPAPADGADPAPVEESEARPDGEGSPSKGRSASARRPAAAASADRDDRGPPTSVAALRSNFEKIRKGPAQPGSADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQQSAGQGLGEAPRPHYRGRSSESSCGLDGDYEDAELNPRFLKDNLINANGGNRPPWPPLEYQPYQSIYVGGMMVEGEGKSPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQKRHRQCQVVVSEATIVGVRKTGQIWPSDGDSTFQGEADSSFGTPPGYGCAADQAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSLASGALDPTKVSELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGFLHVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCYEKCYNKMKMTKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSVKFTSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV",
"length": 1270
},
"evidence": [
{
"id": "45918851",
"url": "http://www.informatics.jax.org/homology/45918851",
"database": "MGI"
},
{
"id": "P11274",
"url": "https://omabrowser.org/oma/group/P11274/",
"database": "OMA"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Cellular Component",
"total": 10,
"go_terms": [
{
"name": "glutamatergic synapse",
"id": "GO:0098978",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "postsynaptic density",
"id": "GO:0014069",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "membrane",
"id": "GO:0016020",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "axon",
"id": "GO:0030424",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "dendritic spine",
"id": "GO:0043197",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "extracellular exosome",
"id": "GO:0070062",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "protein-containing complex",
"id": "GO:0032991",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "Schaffer collateral - CA1 synapse",
"id": "GO:0098685",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 33,
"go_terms": [
{
"name": "negative regulation of macrophage migration",
"id": "GO:1905522",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905522",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "protein phosphorylation",
"id": "GO:0006468",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "signal transduction",
"id": "GO:0007165",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "inner ear morphogenesis",
"id": "GO:0042472",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042472",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "neutrophil degranulation",
"id": "GO:0043312",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043312",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "neuromuscular process controlling balance",
"id": "GO:0050885",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "regulation of small GTPase mediated signal transduction",
"id": "GO:0051056",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "phagocytosis",
"id": "GO:0006909",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "negative regulation of inflammatory response",
"id": "GO:0050728",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "actin cytoskeleton organization",
"id": "GO:0030036",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "keratinocyte differentiation",
"id": "GO:0030216",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030216",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "cellular response to lipopolysaccharide",
"id": "GO:0071222",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "brain development",
"id": "GO:0007420",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "negative regulation of reactive oxygen species metabolic process",
"id": "GO:2000378",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000378",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "negative regulation of cellular extravasation",
"id": "GO:0002692",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002692",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "small GTPase mediated signal transduction",
"id": "GO:0007264",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "regulation of Rho protein signal transduction",
"id": "GO:0035023",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "regulation of vascular permeability",
"id": "GO:0043114",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043114",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "negative regulation of neutrophil degranulation",
"id": "GO:0043314",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043314",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "positive regulation of phagocytosis",
"id": "GO:0050766",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "negative regulation of blood vessel remodeling",
"id": "GO:0060313",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060313",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "focal adhesion assembly",
"id": "GO:0048041",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048041",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "modulation of chemical synaptic transmission",
"id": "GO:0050804",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "activation of GTPase activity",
"id": "GO:0090630",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "intracellular protein transmembrane transport",
"id": "GO:0065002",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065002",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "renal system process",
"id": "GO:0003014",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003014",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "regulation of nitrogen compound metabolic process",
"id": "GO:0051171",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051171",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "definitive hemopoiesis",
"id": "GO:0060216",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060216",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "negative regulation of respiratory burst",
"id": "GO:0060268",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060268",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "homeostasis of number of cells",
"id": "GO:0048872",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048872",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "regulation of cell cycle",
"id": "GO:0051726",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "macrophage migration",
"id": "GO:1905517",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905517",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "intracellular signal transduction",
"id": "GO:0035556",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 6,
"go_terms": [
{
"name": "protein serine/threonine kinase activity",
"id": "GO:0004674",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "protein tyrosine kinase activity",
"id": "GO:0004713",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "GTPase activator activity",
"id": "GO:0005096",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "ATP binding",
"id": "GO:0005524",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "guanyl-nucleotide exchange factor activity",
"id": "GO:0005085",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
},
{
"name": "protein serine kinase activity",
"id": "GO:0106310",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106310",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 337,
"end_pos": 339,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 982,
"end_pos": 984,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.",
"evidence": [
{
"database": "UniProtKB",
"id": "P11274",
"url": "https://www.uniprot.org/uniprot/P11274"
},
{
"database": "PubMed",
"id": "15302586",
"url": "https://glygen.org/publication/PubMed/15302586"
},
{
"database": "PubMed",
"id": "9407116",
"url": "https://glygen.org/publication/PubMed/9407116"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "17989",
"name": "",
"equation": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
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],
"evidence": [
{
"id": "17989",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17989"
}
]
},
{
"id": "46608",
"name": "",
"equation": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"B2DD29-1",
"D3ZML2-1",
"O08875-1",
"O35831-1",
"P57760-1",
"D3ZHP7-1",
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],
"evidence": [
{
"id": "46608",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/46608"
}
]
},
{
"id": "R-HSA-1839031",
"name": "Dimerization of cytosolic FGFR1 fusion proteins",
"equation": "",
"summary": "8p11 myeloproliferative syndrome (EMS) is a myeloproliferative disorder that rapidly progresses to acute myeloid leukemia if not treated (reviewed in Jackson, 2010, Knights and Cook, 2010). A characteristic feature of EMS is the presence of fusion proteins that contain the kinase domain of FGFR1 and the oligomerization domain of an unrelated protein. This is believed to promote the ligand independent dimerization and activation of the kinase domain. To date, there are 11 identified partners that form fusion proteins with FGFR1 in EMS: ZMYM2 (Xiao, 1998; Popovici, 1998; Reiter, 1998; Ollendorff, 1999; Xiao, 2000), FGFR1OP1 (Popovici, 1999), CNTRL (Guasch, 2000), BCR (Demiroglu, 2001), FGFR1OP2 (Grand, 2004), TRIM24 (Belloni, 2005), CUX1 (Wasag, 2011), MYO18A (Walz, 2005), CPSF6 (Hidalgo-Curtis, 2008), HERV-K (Guasch, 2003) and LRRFIP1 (Soler, 2009).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839031",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839031"
}
]
},
{
"id": "R-HSA-1839039",
"name": "Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation",
"equation": "",
"summary": "In a murine mouse model of ZNF198-FGFR1-induced EMS, treatment with the FGFR-inhibitor Midostaurin (PKC412) resulted in prolonged survival (Chen, 2004). Similarly, growth of ZNF-198-FGFR1-, FGFR1OP2-FGFR1-, and BCR-FGFR1-expressing lines is blocked by treatment with FGFR-inhibitors (Demiroglu, 2001; Gu, 2006; Chase, 2007; Zhen, 2007; Wasag, 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839039",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839039"
}
]
},
{
"id": "R-HSA-1839065",
"name": "Phosphorylation of cytosolic FGFR1 fusion dimers",
"equation": "",
"summary": "After ligand-independent dimerization, FGFR1 fusions are trans-autophosphorylated on tyrosine residues (see for instance Popovici, 1998; Ollendorff, 1999; Guasch, 2000). Although the sites of tyrosine phosphorylation have not been mapped in the context of the fusion proteins, at least some of the same residues appear to be phosphorylated as in full length FGFR1. For instance, phospho-specific antibodies have demonstrated that TRIM24 is phosphorylated on Y653 and Y654, the activation loop tyrosines of FGFR1 (Belloni, 2005). Likewise, FGFR1 fusions with ZMYM2, BCR, FGFR1OP and TRIM24 all result in recruitment and phosphorylation of PLCgamma, and where mutational studies have been performed, mutation of the PLCgamma binding site Y766 has been shown to abrogate this signaling (Roumiantsev, 2004, Lelievre, 2008, Chase, 2007). In the case of BCR-FGFR1, the BCR moiety of the fusion protein has also been shown to be phosphorylated on at least one tyrosine residue, Y177, which results in the recruitment of GRB2 (Roumiantsev, 2004).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839065",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839065"
}
]
},
{
"id": "R-HSA-1839067",
"name": "Phosphorylation of BCR moiety of BCR-FGFR1",
"equation": "",
"summary": "Unique among FGFR1 fusion proteins, which generally give rise to an atypical myeloproliferative syndrome (EMS) (reviewed in Jackson, 2010), the BCR-FGFR1 fusion results in a more typical chronic myeloid leukemia (CML). Although both EMS and CML activate PLCgamma signaling, and mutation of the FGFR1 Y766 PLCgamma binding site attenuates both diseases, CML-specific signaling also appears to be mediated through the BCR portion of the fusion protein. BCR Y177 binds GRB2-GAB1 and induces CML-like leukemia in mice, while expression of a Y177F BCR-FGFR1 fusion induces EMS-like disease (Roumiantsev, 2004).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839067",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839067"
}
]
},
{
"id": "R-HSA-1839078",
"name": "Cytosolic FGFR1 fusion proteins bind PIK3R1",
"equation": "",
"summary": "Activation of the PI3K signaling pathway has been demonstrated for a number of FGFR1 fusion proteins and inhibitors of this pathway impair the proliferative and survival function of the fusions (Guasch, 2001; Demiroglu, 2001; Chen, 2004; Lelievre, 2008). FGFR1 fusions lack the FRS2-binding site of the full length protein, so the mechanism of PI3K recruitment is unclear. Unlike BCR-FGFR1, which has been shown to recruit GRB2 through the BCR Y177 site, GRB2 did not co-precipitate with the ZMYM2-FGFR1 fusion (Roumianetsev, 2004). In the case of FOP-FGFR1, Y730 has been shown to be required for the recruitment of the p85 subunit of PI3K; however, CEP110-FGFR1, which contains Y730 in the context of the same pYXXM motif, was not shown to recruit p85 at the centrosome (Guasch, 2001).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839078",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839078"
}
]
},
{
"id": "R-HSA-1839080",
"name": "Activated cytosolic FGFR1 fusions bind PIK3CA",
"equation": "",
"summary": "Activation of the PI3K pathway has been demonstrated in the case of ZMYM2-FGFR1 (Chen, 2004), BCR-FGFR1 (Demiroglu, 2001) and FOP-FGFR1 (Guasch, 2001), and is presumed to occur to a greater or lesser extent in other FGFR1 fusions as well (reviewed in Jackson, 2010). Activation of the PI3K pathway suggests that the PIK3CA catalytic subunit must be recruited to the fusion protein.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P42336-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839080",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839080"
}
]
},
{
"id": "R-HSA-1839091",
"name": "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3",
"equation": "",
"summary": "Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P42336-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839091",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839091"
}
]
},
{
"id": "R-HSA-1839094",
"name": "Activated FGFR1 mutants and fusions bind PLCG1",
"equation": "",
"summary": "Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established. FGFR1 fusions with ZMYM2, BCR, FGFR1OP and TRIM24 all result in recruitment and phosphorylation of PLCgamma, and where mutational studies have been performed, mutation of the PLCgamma binding site Y766 has been shown to abrogate this signaling (Guasch, 2001; Roumiantsev, 2004, Lelievre, 2008, Chase, 2007). In the case of BCR-FGFR1 and ZMYM2-FGFR1, mutation of the PLCgamma binding site significantly decreased the transformative phenotype of the FGFR1 fusion (Roumiantsev, 2004).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P19174-1",
"P11362-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839094",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839094"
}
]
},
{
"id": "R-HSA-1839095",
"name": "p-BCR-pFGFR1 binds GRB2:GAB2",
"equation": "",
"summary": "Proliferation of BCR-FGFR1 fusion proteins is blocked by treatment with the PI3K inhibitor LY294002, suggesting the activation of this pathway downstream of BCR-FGFR1 phosphorylation. Y177 has been shown to be a binding site for GRB2 and to be required for the both the phosphorylation of GAB2 and the development of CML-like disease (Roumiantsev, 2004, Demiroglu, 2001). By analogy with studies in BCR-ABL, where mutation of Y177 abrogates recruitment of PI3K activity to the fusion protein (Sattler, 2002), this suggests that Y177 may serve as a docking site for a complex of GRB2:GAB1:PI3K in the context of BCR-FGFR1 as well.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839095",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839095"
}
]
},
{
"id": "R-HSA-1839098",
"name": "Activated FGFR1 mutants and fusions phosphorylate PLCG1",
"equation": "",
"summary": "By analogy with the wild-type pathway, PLC-gamma is presumed to be phosphorylated by activated FGFR mutants, resulting in PLC-gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P19174-1",
"P11362-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839098",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839098"
}
]
},
{
"id": "R-HSA-1839100",
"name": "p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions",
"equation": "",
"summary": "Dissociation from the activated receptor quickly follows phosphorylation of PLC-gamma. Phosphorylated PLC-gamma catalyzes the hydrolysis of phosphatidylinositol(4, 5)bisphosphate to generate two second messengers, diacylglycerol and inositol (1,4,5) triphosphate.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"P19174-1",
"P11362-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839100",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839100"
}
]
},
{
"id": "R-HSA-1839102",
"name": "BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA",
"equation": "",
"summary": "Activation of the PI3K pathway has been demonstrated in the case of ZMYM2-FGFR1 (Chen, 2004), BCR-FGFR1 (Demiroglu, 2001) and FOP-FGFR1 (Guasch, 2001), and is presumed to occur to a greater or lesser extent in other FGFR1 fusions as well (reviewed in Jackson, 2010). Activation of the PI3K pathway suggests that the PIK3CA catalytic subunit must be recruited to the fusion protein.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P42336-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839102",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839102"
}
]
},
{
"id": "R-HSA-1839107",
"name": "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.",
"equation": "",
"summary": "Once recruited to the activated BCR-FGFR1 fusion PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling (Roumiantsev, 2004; Demiroglu, 2001).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P42336-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839107",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839107"
}
]
},
{
"id": "R-HSA-1839110",
"name": "p-BCR-p-FGFR1 phosphorylates GAB2",
"equation": "",
"summary": "Recruitment of GAB2 to the BCR-FGFR1 fusion protein results in GAB2 phosphorylation (Roumiatnetsev, 2004). As in the case of BCR-ABL (Sattler, 2002), recruitment and phosphorylation of GAB2 is dependent on BCR residue Y177. Deletion of Y177 abolishes GRB2 recruitment and converts the more aggressive MPD disorder induced by BCR-FGFR1 to the EMS characteristic of other FGFR1 fusions (Demiroglu, 2001; Roumianetsev, 2004)",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839110",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839110"
}
]
},
{
"id": "R-HSA-1839112",
"name": "Phosphorylation of STAT5 by cytosolic FGFR1 fusions",
"equation": "",
"summary": "Activation of a subset of FGFR1-fusions (ZMYM2, BCR, FGFR1OP2 and CUX) has been shown to result in downstream phosphorylation of STAT5 proteins at Y694. This phosphorylation is dependent on the FGFR1 fusion, as the STAT5 phosphorylation is abrogated in the presence of an FGFR1-kinase dead fusion (Heath and Cross, 2004; Smedley, 1999; Chase, 2007; Wasage, 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839112",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839112"
}
]
},
{
"id": "R-HSA-1839114",
"name": "BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1",
"equation": "",
"summary": "Based on analogy with studies of the BCR-ABL fusion, phosphorylated GAB2 recruits the regulatory subunit of PI3K to the BCR-FGFR1 fusion (Sattler, 2002; Demiroglu, 2001; Roumiantsev, 2004).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-1839114",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1839114"
}
]
},
{
"id": "R-HSA-8980691",
"name": "RHOA GEFs activate RHOA",
"equation": "",
"summary": "The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOA and catalyze GDP to GTP exchange on RHOA, resulting in formation of the active RHOA:GTP complex (the high throughput study by Bagci et al. 2020 looked at preferential binding of GEFs to nucleotide-free RHOA mutant compared to wild type RHOA but did not examine guanine nucleotide exchange):
AKAP13 (Zheng et al. 1995; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGEF1 (Hart et al. 1996; Jaiswal et al. 2011; Jaiswal et al. 2013; Toffali et al. 2017; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGEF2 (Krendel et al. 2002; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGEF3 (Arthur et al. 2002; Sloan et al. 2012; M\u00fcller et al. 2020)
ARHGEF5 (Xie et al. 2005; Wang et al. 2009; supported by Bagci et al. 2020)
ARHGEF10 (Mohl et al. 2006; Aoki et al. 2009; M\u00fcller et al. 2020)
ARHGEF11 (R\u00fcmenapp et al. 1999; Jaiswal et al. 2011; Jaiswal et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGEF12 (Reuther et al. 2001; Jaiswal et al. 2011; Jaiswal et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGEF15 (Fukushima et al. 2016; M\u00fcller et al. 2020)
ARHGEF17 (R\u00fcmenapp et al. 2002; Mitin et al. 2012; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGEF19 (Wang et al. 2004; M\u00fcller et al. 2020)
ARHGEF25 (Sloan et al. 2012; M\u00fcller et al. 2020)
ARHGEF28 (van Horck et al. 2001; Jaiswal et al. 2011; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ECT2 (Tatsumoto et al. 1999; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
MCF2 (Sloan et al. 2012; Jaiswal et al. 2013; M\u00fcller et al. 2020)
NET1 (Alberts and Treisman 1998; M\u00fcller et al. 2020)
NGEF (Zhang et al. 2007; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
OBSCN (Ford Speelman et al. 2009)
PLEKHG5 (de Toledo et al. 2001; Liu and Horowitz 2006; M\u00fcller et al. 2020)
PLEKHG6 (M\u00fcller et al. 2020)
RASGRF2 (M\u00fcller et al. 2020)
TRIO (TRIO and KALRN possess two GEF domains, the N-terminal GEF1 and the C-terminal GEF2; Debant et al. 1996 demonstrated activation of RHOA by the C-terminal GEF2 domain of TRIO, while Peurois et al. 2017 demonstrated activation of RHOA by the N-terminal GEF1 domain of TRIO in the presence of membranes, Williams et al. 2007 showed that in C-elegans GNAQ-mediated activation of TRIO results in RHOA activation that drived locomotion and egg laying, and Bagci et al. 2020 reported binding of inactive RHOA mutant to the full-length TRIO; Debant et al. 1996 and Jaiswal et al. 2013 showed that the N-terminal GEF1 domain of TRIO does not activate RHOA; M\u00fcller et al. 2020 detected no activation of RHOA in the presence of full-length TRIO, but in this study HEK293 cells were used, which were previously shown by Williams et al. 2007 to have a low TRIO-activation ability downstream of GNAQ)
VAV1 (Heo et al. 2005; M\u00fcller et al. 2020)
VAV2 (Heo et al. 2005; Sloan et al. 2012; Schuebel et al. 1998; Jaiswal et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
VAV3 (Movilla and Bustelo 1999, Sachdev et al. 2002; M\u00fcller et al. 2020)
They are annotated as RHOA GEF set members.
The following GEFs were shown to bind and activate RHOA in some but not all studies, or have not been sufficiently studied, and are annotated as candidate RHOA GEFs:
ABR (Chuang et al. 1995, Manser et al. 1998: activation of RHOA; M\u00fcller et al. 2020: no activation of RHOA)
ARHGEF4 (M\u00fcller et al. 2020: activation of RHOA; Gotthardt and Ahmadian 2007, Anderson and Hamann 2012, Jaiswal et al. 2013: no activation of RHOA)
ARHGEF7 (Manser et al. 1998: activation of RHOA; Jones and Katan 2007, M\u00fcller et al. 2020: no activation of RHOA; Bagci et al. 2020: no binding to RHOA)
ARHGEF10L (Winkler et al. 2005: activation of RHOA; M\u00fcller et al. 2020: no activation of RHOA)
ARHGEF18 (Niu et al. 2003, Blomquist et al. 2000: activation of RHOA; M\u00fcller et al. 2020: no activation of RHOA)
ARHGEF40 (Curtis et al. 2004: activation of RHOA; M\u00fcller et al. 2020: no activation of RHOA; Bagci et al. 2020: no binding to RHOA)
BCR (Chuang et al. 1995: activation of RHOA; Bagci et al. 2020: binding to RHOA; M\u00fcller et al. 2020: no activation of RHOA)
DEF6 (Mavrakis et al. 2004: probable GEF, in vitro GEF activity not tested)
DOCK2 (Toffali et al. 2017: inconclusive; M\u00fcller et al. 2020: no activation of RHOA)
FARP1 (Koyano et al. 2001: activation of RHOA; M\u00fcller et al. 2020: no activation of RHOA; Bagci et al. 2020: inconclusive binding to RHOA)
KALRN (Penzes et al. 2001: the C-terminal GEF2 domain of KALRN binds RHOA and activates it, although activation was not demonstrated in vitro, while the N-terminal GEF1 domain of KALRN does not bind to RHOA; Wu et al. 2013: no effect on RHOA activity in mice with heterozygous Kalrn gene knockout; M\u00fcller et al. 2020: no activation of RHOA by full-length KALRN)
MCF2L (Whitehead et al. 1999, Sloan et al. 2012, Jaiswal et al. 2013, M\u00fcller et al. 2020: activation of RHOA; Bagci et al. 2020: no binding to RHOA)
PLEKHG3 (Bagci et al. 2020: binding to RHOA, RHOA activation not tested; M\u00fcller et al. 2020: no activation of RHOA)
PLEKHG4 (Gupta et al. 2013: activation of RHOA; M\u00fcller et al. 2020: no activation of RHOA; Bagci et al. 2020: no binding to RHOA)
PREX1 (Jaiswal et al. 2013: activation of RHOA; Marei et al. 2016, M\u00fcller et al. 2020: no activation of RHOA)
PREX2 (M\u00fcller et al. 2020: activation of RHOA; Joseph and Norris 2005: no activation of RHOA)
TIAM1 (Michiels et al. 1995: activation of RHOA; Jaiswal et al. 2013, M\u00fcller et al. 2020: no activation of RHOA; Bagci et al. 2020: no binding to RHOA)
The following GEFs do not act on RHOA or have been reported to not bind to RHOA, as indicated, without testing for activity:
ALS2 (M\u00fcller et al. 2020)
ARHGEF6 (Ramakers et al. 2012; M\u00fcller et al. 2020)
ARHGEF9 (Reid et al. 1999; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ARHGEF16 (Hiramoto Yamaki et al. 2010; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
ARHGEF26 (Ellerbroek et al. 2004; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
ARHGEF39 (M\u00fcller et al. 2020)
DNMBP (Jaiswal et al. 2013; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK1 (C\u00f4t\u00e9 and Vuori 2002; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK3 (M\u00fcller et al. 2020)
DOCK4 (M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK5 (M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK6 (M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK7 (M\u00fcller et al. 2020; no binding to RHOA byBagci et al. 2020)
DOCK8 (M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK9 (Ruiz Lafuente et al. 2015; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK10 (Ruiz Lafuente et al. 2015; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
DOCK11 (Ruiz Lafuente et al. 2015; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
ECT2L (M\u00fcller et al. 2020)
FARP2 (Kubo et al. 2002; M\u00fcller et al. 2020);
FGD1 (Olson et al. 1996; M\u00fcller et al. 2020)
FGD2 (Huber et al. 2008; M\u00fcller et al. 2020)
FGD3 (M\u00fcller et al. 2020)
FGD5 (M\u00fcller et al. 2020)
FGD6 (M\u00fcller et al. 2020)
FGD4 (Umikawa et al. 1999; M\u00fcller et al. 2020)
GNA13 (Teo et al. 2016)
ITSN1 (Hussain et al. 2001; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ITSN2 (M\u00fcller et al. 2020)
MCF2L2 (M\u00fcller et al. 2020)
PLEKHG1 (Abiko et al. 2015; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
PLEKHG2 (Ueda et al. 2008; M\u00fcller et al. 2020; no binding to RHOA by Bagci et al. 2020)
PLEKHG4B (M\u00fcller et al. 2020)
SOS1 (Nimnual et al. 1998; M\u00fcller et al. 2020)
SOS2 (Nimnual et al. 1998; M\u00fcller et al. 2020)
SPATA13 (Hamann et al. 2007; Kawasaki et al. 2007; Bristow et al. 2009; M\u00fcller et al. 2020)
SWAP70 (Ocana Morgner et al. 2009; no binding to RHOA by Bagci et al. 2020)
TIAM2 (M\u00fcller et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O60229-1",
"Q5VST9-1",
"P61586-1",
"P11274-1",
"O75962-1"
],
"evidence": [
{
"id": "R-HSA-8980691",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980691"
}
]
},
{
"id": "R-HSA-8981637",
"name": "RHOA GAPs stimulate RHOA GTPase activity",
"equation": "",
"summary": "The following GTPase activating proteins (GAPs) were shown to bind RHOA and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOA:GTP complex into the inactive RHOA:GDP complex (the high throughput study by Bagci et al. 2020 looked at preferential binding of GAPs to active RHOA mutant compared to wild type RHOA but did not examine activation of GTPase activity):
ARHGAP5 (Burbelo et al. 1995; Kusama et al. 2006; Amin et al. 2016; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP6 (Prakash et al. 2000; M\u00fcller et al. 2020)
ARHGAP8 (Lua and Low 2004; M\u00fcller et al. 2020)
ARHGAP10 (Shibata et al. 2001; M\u00fcller et al. 2020)
ARHGAP11A (Lawson et al. 2016; M\u00fcller et al. 2020)
ARHGAP11B (M\u00fcller et al. 2020)
ARHGAP19 (David et al. 2014; M\u00fcller et al. 2020)
ARHGAP20 (M\u00fcller et al. 2020)
ARHGAP21 (Sousa et al. 2005; Lazarini et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP23 (M\u00fcller et al. 2020)
ARHGAP26 (Hildebrand et al. 1996; Sheffield et al. 1999; Amin et al. 2016; M\u00fcller et al. 2020)
ARHGAP28 (Yeung et al. 2014; M\u00fcller et al. 2020)
ARHGAP29 (Saras et al. 1997; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP30 (Naji et al. 2011; M\u00fcller et al. 2020)
ARHGAP40 (M\u00fcller et al. 2020)
DLC1 (Healy et al. 2008; Amin et al. 2016; M\u00fcller et al. 2020)
GMIP (Aresta et al. 2002; M\u00fcller et al. 2020)
HMHA1 (de Kreuk et al. 2013)
MYO9A (Handa et al. 2013; Omelchenko and Hall 2012; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
MYO9B (Post et al. 1998; Graf et al. 2000; Kong et al. 2015; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
TAGAP (Bauer et al. 2005; M\u00fcller et al. 2020)
The following GAPs were shown to bind RHOA and stimulate its GTPase activity in some but not all studies and are annotated as candidate RHOA GAPs:
ABR (Bagci et al. 2020: binding to active RHOA; Chuang et al. 1995, Amin et al. 2016, M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARAP1 (Miura et al. 2002: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARAP2 (M\u00fcller et al. 2020: activation of RHOA GTPase activity; Yoon et al. 2006: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARAP3 (Krugmann et al. 2002: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP1 (Zhang and Zheng 1998, Amin et al. 2016, M\u00fcller et al. 2020: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Yang et al. 2006, Li et al. 2009: no activation of RHOA GTPase activity)
ARHGAP4 (Vogt et al. 2007: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP9 (Furukawa et al. 2001: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP18 (Maeda et al. 2011: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP22 (M\u00fcller et al. 2020: activation of RHOA GTPase activity; Mori et al. 2014: no activation of RHOA GTPase activity)
ARHGAP24 (Su et al. 2004: activation of RHOA GTPase activity; Lavelin and Geiger 2005, Ohta et al. 2006, M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP31 (M\u00fcller et al. 2020: activation of RHOA GTPase activity; Tcherkezian et al. 2006: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP32 (Nakazawa et al. 2003: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP35 (Levay et al. 2009, Amin et al. 2016; M\u00fcller et al. 2020: activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP39 (Bagci et al. 2020: binding to active RHOA; Lundstrom et al. 2004, M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP42 (Bai et al. 2013, Luo et al. 2017, Bai et al. 2017: activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP44 (Raynaud et al. 2014: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
BCR (Zhang and Zheng 1998: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Chuang et al. 1995, M\u00fcller et al. 2020: no activation of RHOA GTPase activity),
DEPDC1B (Bagci et al. 2020: binding to active RHOA; Wu et al. 2015, M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
FAM13A (Li et al. 2015: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
OPHN1 (Elvers et al. 2012, Amin et al. 2016: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
PIK3R1 (Bagci et al. 2020: binding to active RHOA; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
PIK3R2 (Bagci et al. 2020: binding to active RHOA; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
RACGAP1 (Toure et al. 1998; Amin et al. 2016: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
SRGAP1 (Wong et al. 2001: activation of RHOA GTPase activity; M\u00fcller et al. 2020: no activation of RHOA GTPase activity)
STARD8 (Kawai et al. 2007, M\u00fcller et al. 2020: activation of RHOA GTPase activity; Amin et al. 2016: no activation of RHOA GTPase activity)
STARD13 (Ching et al. 2003, Leung et al. 2005, M\u00fcller et al. 2020: activation of RHOA GTPase activity; Amin et al. 2016: no activation of RHOA GTPase activity)
The following GAPs do not act on RHOA or were shown to not bind to active RHOA without testing for activation of RHOA GTPase activity:
ARHGAP12 (M\u00fcller et al. 2020; Bagci et al. 2020: no binding to RHOA)
ARHGAP15 (Seoh et al. 2003; M\u00fcller et al. 2020)
ARHGAP17 (Richnau and Aspenstrom 2001; Amin et al. 2016; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to RHOA)
ARHGAP25 (Csepanyi Komi et al. 2012; M\u00fcller et al. 2020)
ARHGAP27 (Sakakibara et al. 2004; M\u00fcller et al. 2020)
ARHGAP33 (Liu et al. 2006; M\u00fcller et al. 2020)
ARHGAP36 (M\u00fcller et al. 2020)
ARHGAP45 (M\u00fcller et al. 2020)
CHN1 (Ahmed et al. 1994; M\u00fcller et al. 2020)
CHN2 (Caloca et al. 2003; M\u00fcller et al. 2020)
DEPDC1 (M\u00fcller et al. 2020)
FAM13B (M\u00fcller et al. 2020)
INPP5B (M\u00fcller et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
RALBP1 (Jullien Flores et al. 1995; M\u00fcller et al. 2020)
SH3BP1 (M\u00fcller et al. 2020)
SRGAP2 (Mason et al. 2011; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
SRGAP3 (Endris et al. 2002; M\u00fcller et al. 2020)
SYDE1 (M\u00fcller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
SYDE2 (M\u00fcller et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P61586-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-8981637",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8981637"
}
]
},
{
"id": "R-HSA-9013022",
"name": "RHOB GAPs stimulate RHOB GTPase activity",
"equation": "",
"summary": "The following GTPase activating proteins (GAPs) were shown to bind RHOB and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOB:GTP complex into the inactive RHOB:GDP complex (the high throughput study by Bagci et al. 2020 examined binding to the active RHOB mutant but not activation of RHOB GTPase activity):
ABR (Amin et al. 2016, supported by Bagci et al. 2020)
ARHGAP1 (Amin et al. 2016, supported by Bagci et al. 2020)
ARHGAP5 (Kusama et al. 2006, supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
DLC1 (Healy et al. 2008, Amin et al. 2016)
MYO9B (Graf et al. 2000, supported by Bagci et al. 2020)
STARD13 (Amin et al. 2016)
The following GAPs were shown to bind RHOB and stimulate its GTPase activity in some but not all studies or have only been shown to bind to the active RHOB (as indicated) and are annotated as candidate RHOB GAPs:
ARHGAP21 (Bagci et al. 2020: binds to active RHOB)
ARHGAP32 (Bagci et al. 2020: binds to active RHOB)
ARHGAP35 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
ARHGAP39 (Bagci et al. 2020: binds to active RHOB)
BCR (Bagci et al. 2020: binds to active RHOB)
DEPDC1B (Bagci et al. 2020: binds to active RHOB)
MYO9A (Bagci et al. 2020: binds to active RHOB)
OPHN1 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
PIK3R1 (Bagci et al. 2020: binds to active RHOB)
PIK3R2 (Bagci et al. 2020: binds to active RHOB)
RACGAP1 (RHOB directed GAP activity: Amin et al. 2016; Bagci et al. 2020: no binding to active RHOB)
STARD8 (RHOB directed GAP activity: Braun et al. 2015; no RHOB directed GAP activity: Amin et al. 2016)
The following GAPs do not act on RHOB or were shown to not bind to the active RHOB, without testing for the ability to activate RHOB GTPase activity (as indicated):
ARAP2 (Bagci et al. 2020: does not bind active RHOB)
ARAP3 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP12 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020: does not bind active RHOB)
ARHGAP29 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP31 (Bagci et al. 2020: does not bind active RHOB)
ARHGAP42 (Bagci et al. 2020: does not bind active RHOB)
SRGAP2 (Bagci et al. 2020: does not bind active RHOB)
SYDE1 (Bagci et al. 2020: does not bind active RHOB)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-9013022",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013022"
}
]
},
{
"id": "R-HSA-9013024",
"name": "RHOB binds effectors at the plasma membrane",
"equation": "",
"summary": "In its GTP bound active form, plasma membrane associated RHOB (or constitutively active RHOB mutant in the high throughput study by Bagci et al. 2020) binds to the following effectors at the plasma membrane:
CIT (Madaule et al. 1995; Bagci et al. 2020) and its neuron specific isoform CIT 3 (Di Cunto et al. 1998)
DAAM1 (Higashi et al. 2008)
PKN1 (Hutchinson et al. 2013)
PKN2 (Hutchinson et al. 2013; Bagci et al. 2020)
PKN3 (Hutchinson et al. 2013)
ROCK1 (Leung et al. 1996; Bagci et al. 2020)
ROCK2 (Leung et al. 1996; Bagci et al. 2020)
RTKN (Reid et al. 1996)
The following putative RHOB effectors were identified only in the high throughput study by Bagci et al. 2020, where they were shown to bind to the active mutant of RHOB, and are annotated as candidate RHOB effectors:
ACTC1 (Bagci et al. 2020)
ANLN (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CAVIN1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FLOT1 (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
PCDH7 (Bagci et al. 2020)
SLK (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STK10 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TJP2 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
Active RHOB does not bind the following effectors:
AAAS (Bagci et al. 2020)
ABCD3 (Bagci et al. 2020)
ACBD5 (Bagci et al. 2020)
ATP6AP1 (Bagci et al. 2020)
BCAP31 (Bagci et al. 2020)
C1QBP (Bagci et al. 2020)
CCDC115 (Bagci et al. 2020)
CCDC187 (Bagci et al. 2020)
DDRGK1 (Bagci et al. 2020)
EMC3 (Bagci et al. 2020)
FAF2 (Bagci et al. 2020)
FMNL2 (Kitzing et al. 2010)
FMNL3 (Bagci et al. 2020)
HMOX2 (Bagci et al. 2020)
IQGAP1 (Casteel et al. 2012)
KIAA0355 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
MACO1 (Bagci et al. 2020)
LMAN1 (Bagci et al. 2020)
PGRMC2 (Bagci et al. 2020)
RHOA (Bagci et al. 2020)
SCFD1 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
TEX2 (Bagci et al. 2020)
TMEM87A (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAPB (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O14578-1",
"O75116-1",
"P68032-1",
"Q16512-1",
"P11274-1",
"Q6P5Z2-1",
"Q9H2G2-1",
"Q16513-1",
"O94804-1"
],
"evidence": [
{
"id": "R-HSA-9013024",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013024"
}
]
},
{
"id": "R-HSA-9013110",
"name": "RHOC binds effectors at the plasma membrane",
"equation": "",
"summary": "In its GTP bound active form, plasma membrane associated RHOC binds to the following cytosolic and plasma membrane effectors:
CIT (Madaule et al. 1995; Bagci et al. 2020) and its neuron specific isoform CIT 3 (Di Cunto et al. 1998)
DAAM1 (Higashi et al. 2008)
DIAPH1 (Higashi et al. 2008)
FMNL2 (Kitzing et al. 2010, Moriya et al. 2012)
IQGAP1 (Casteel et al. 2012)
PKN1 (Hutchinson et al. 2013)
PKN2 (Hutchinson et al. 2013, Bagci et al. 2020)
PKN3 (Hutchinson et al. 2013)
ROCK1 (Leung et al. 1996, Bagci et al. 2020)
ROCK2 (Leung et al. 1996, Bagci et al. 2020)
RTKN (Reid et al. 1996)
Opposing findings have been reported on the following putative RHOC effectors, or they were identified only in the high throughput study by Bagci et al. 2020, where they were shown to bind to the active mutant of RHOC; they are therefore annotated as candidate RHOC effectors:
ABCD3 (Bagci et al. 2020)
ACBD5 (Bagci et al. 2020)
ANLN (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
C1QBP (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CAVIN1 (Bagci et al. 2020)
CCDC187 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FLOT1 (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
FMNL3 (Vega et al. 2011: binds to activated RHOC; Bagci et al. 2020: does not bind to active RHOC)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
RHOA (Bagci et al. 2020)
SLK (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STK10 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TJP2 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
Active RHOC does not bind to
AAAS (Bagci et al. 2020)
ACTC1 (Bagci et al. 2020)
ATP6AP1 (Bagci et al. 2020)
BCAP31 (Bagci et al. 2020)
CCDC115 (Bagci et al. 2020)
DDRGK1 (Bagci et al. 2020)
EMC3 (Bagci et al. 2020)
FAF2 (Bagci et al. 2020)
HMOX2 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
PCDH7 (Bagci et al. 2020)
SCFD1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
TEX2 (Bagci et al. 2020)
TMEM87A (Bagci et al. 2020)
FMNL3 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O14578-1",
"O75116-1",
"P28288-1",
"Q16512-1",
"P61586-1",
"P11274-1",
"Q6P5Z2-1",
"Q9H2G2-1",
"Q16513-1",
"O94804-1"
],
"evidence": [
{
"id": "R-HSA-9013110",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013110"
}
]
},
{
"id": "R-HSA-9013111",
"name": "RHOC GAPs stimulate RHOC GTPase activity",
"equation": "",
"summary": "The following GTPase activating proteins (GAPs) were shown to bind RHOC and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOC:GTP complex into the inactive RHOC:GDP complex, or they were shown to bind to the constitutively active RHOC mutant in the high throughput screen conducted by Bagci et al. 2020, without testing for activation of RHOC GTPase activity (as indicated):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP5 (Kusama et al. 2006; supported by Bagci et al. 2020)
ARHGAP18 (Chang et al. 2014)
ARHGAP26 (Amin et al. 2016)
DLC1 (Healy et al. 2008; Amin et al. 2016)
MYO9B (Graf et al. 2000; supported by Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
STARD13 (Amin et al. 2016)
The following GAPs were shown to bind RHOC and stimulate its GTPase activity in some but not all studies, or only their binding to the constitutively active RHOC mutant was shown without testing for activation of RHOC GTPase activity, and they are annotated as candidate RHOC GAPs:
ABR (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP21 (Lazarini et al. 2013: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP32 (Bagci et al. 2020: binding to active RHOC)
ARHGAP35 (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
ARHGAP39 (Bagci et al. 2020: binding to active RHOC)
BCR (Bagci et al. 2020: binding to active RHOC)
DEPDC1B (Bagci et al. 2020: binding to active RHOC)
OPHN1 (Amin et al. 2016: RHOC directed GAP activity; Bagci et al. 2020: no binding to active RHOC)
PIK3R1 (Bagci et al. 2020: binding to active RHOC)
The following GAPs do not act on RHOC or do not bind to the constitutively active RHOC mutant:
ARAP2 (Yoon et al. 2006; Bagci et al. 2020: no binding to active RHOC)
ARAP3 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP12 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020: no binding to active RHOC)
ARHGAP29 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP31 (Bagci et al. 2020: no binding to active RHOC)
ARHGAP42 (Bagci et al. 2020: no binding to active RHOC)
MYO9A (Bagci et al. 2020: no binding to active RHOC)
OCRL (Erdmann et al. 2006;Lichter Konecki et al. 2006; Bagci et al. 2020: no binding to active RHOC)
PIK3R2 (Bagci et al. 2020: no binding to active RHOC)
SRGAP2 (Bagci et al. 2020: no binding to active RHOC)
STARD8 (Amin et al. 2016)
SYDE1 (Bagci et al. 2020: no binding to active RHOC)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-9013111",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013111"
}
]
},
{
"id": "R-HSA-9013143",
"name": "RAC1 GEFs activate RAC1",
"equation": "",
"summary": "The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC1 and catalyze GDP to GTP exchange on RAC1, resulting in formation of the active RAC1:GTP complex (the high throughput study by Bagci et al. examined binding of GEFs to inactive RAC1 mutant without testing for RAC1-directed GEF activity and is cited as supporting evidence):
DOCK3 (Namekata et al. 2004, Yang et al. 2012, Namekata et al. 2012; M\u00fcller et al. 2020)
FGD5 (M\u00fcller et al. 2020)
GNA13 (Radhika et al. 2004)
PLEKHG6 (M\u00fcller et al. 2020)
PREX1 (Yoshizawa et al. 2005; Dong et al. 2005; Marei et al. 2016; Jaiswal et al. 2013; M\u00fcller et al. 2020)
PREX2 (Joseph and Norris 2005; M\u00fcller et al. 2020)
RASGRF2 (Schwechter et al. 2013; M\u00fcller et al. 2020)
SWAP70 (Shinohara et al. 2002; Gupta et al. 2003; Baranov et al. 2016; Bagci et al. 2020: binding to inactive RAC1)
TIAM2 (Matsuo et al. 2002; M\u00fcller et al. 2020)
TRIO (Debant et al. 1996; Moshfegh et al. 2014; Peurois et al. 2017; Jaiswal et al. 2013: RAC1-directed GEF acivity of the N-terminal GEF1 domain of TRIO; M\u00fcller et al. 2020: RAC1-directed GEF activity of the full-length TRIO; Bagci et al. 2020: binding of full-length TRIO to inactive RAC1)
VAV1 (Teramoto et al. 1997; Heo et al. 2005; Aghazadeh et al. 2000; Crespo et al. 1997; M\u00fcller et al. 2020)
VAV2 (Itoh et al. 2008; Aoki et al. 2005; Heo et al. 2005; Jaiswal et al. 2013; M\u00fcller et al. 2020; Bagci et al. 2020: binding to inactive RAC1)
The following GEFs were shown to bind and activate RAC1 in some but not all studies and are annotated as candidate RAC1 GEFs (or were shown, in the high throughput screen by Bagci et al. 2020, to bind to nucleotide free RAC1 mutant, as indicated):
ABR (Chuang et al. 1995: RAC1-directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ALS2 (Topp et al. 2004, Kanekura et al. 2005, Topp et al. 2005: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF4 (Itoh et al. 2008: RAC1 directed GEF activity; Anderson and Hamann 2012, Gotthardt and Ahmadian 2007, Jaiswal et al. 2013, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF5 (Xie et al. 2005: RAC1 directed GEF activity; Wang et al. 2009, M\u00fcller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF6 (Manser et al. 1998, Ramakers et al. 2012: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF7 (Ten Klooster et al. 2006, Manser et al. 1998: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF10 (M\u00fcller et al. 2020: RAC1 directed GEF activity; Mohl et al. 2006: no RAC1 directed GEF activity)
ARHGEF11 (Bagci et al. 2020: binding to inactive RAC1; R\u00fcmenapp et al. 1999; Jaiswal et al. 2011; Jaiswal et al. 2013; M\u00fcller et al. 2020: no RAC1 directed GEF activity:)
ARHGEF15 (Fukushima et al. 2016: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF18 (Niu et al. 2003: RAC1 directed GEF activity; Blomquist et al. 2000, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF19 (Wang et al. 2004: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF25 (Guo et al. 2003: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ARHGEF39 (Zhou et al. 2018: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
BCR (Chuang et al. 1995: RAC1 directed GEF activity; Bagci et al. 2020 binding to inactive RAC1; Korus et al. 2002, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DEF6 (Mavrakis et al. 2004: activation of RAC1, GEF activity of DEF6 has not been examined in vitro)
DOCK1 (Cote and Vuori 2002, Li et al. 2003: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK2 (Kulkarni et al. 2011: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK4 (Abraham et al. 2015: RAC1-directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK5 (Omi et al. 2008, Vives et al. 2011, Ferrandez et al. 2017: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK6 (Miyamoto et al. 2007: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK7 (Kukimoto Niino et al. 2019, Yamauchi et al. 2008, Majewski et al. 2012, Zhou et al. 2013: RAC1 directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK8 (Wang et al. 2015: RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK9 (Bagci et al. 2020: binding to inactive RAC1; Kulkarni et al. 2011, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
DOCK10 (Ruiz Lafuente et al. 2015, M\u00fcller et al. 2020: RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
DOCK11 (Bagci et al. 2020: binding to inactive RAC1; Lin et al. 2006, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
ECT2 (Tatsumoto et al. 1999: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
FARP1 (Cheadle and Biederer 2012: RAC1-directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
FARP2 (Kubo et al. 2002: RAC1-directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
KALRN (Penzes et al. 2003, Wu et al. 2013: RAC1-directed GEF activity when using the N-terminal GEF1 domain of KALRN; M\u00fcller et al. 2020: no RAC1 directed GEF activity when using full-length KALRN)
MCF2 (Jaiswal et al. 2013, M\u00fcller et al. 2020: RAC1 directed GEF activity; Reuther et al. 2001: no RAC1 directed GEF activity);
MCF2L (Bagci et al. 2020: binding to inactive RAC1; Whitehead et al. 1999; Jaiswal et al. 2013; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
NGEF (Zhang et al. 2007: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
PLEKHG1 (Abiko et al. 2015: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
PLEKHG2 (Ueda et al. 2008: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
PLEKHG3 (Nguyen et al. 2016: RAC1-directed GEF activity; Bagci et al. 2020: binding to inactive RAC1; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
PLEKHG4 (Gupta et al. 2013: RAC1 directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
SOS1 (Nimnual et al. 1998: RAC1 directed GEF activity; Itoh et al. 2008, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
SOS2 (Nimnual et al. 1998: RAC1 directed GEF activity; Itoh et al. 2008, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
SPATA13 (Kawasaki et al. 2007, Bristow et al. 2009: RAC1 directed GEF activity; Hamann et al. 2007, M\u00fcller et al. 2020: no RAC1 directed GEF activity)
TIAM1 (Itoh et al. 2008, Michiels et al. 1995, Haeusler et al. 2003, Jaiswal et al. 2013, M\u00fcller et al. 2020: RAC1 directed GEF activity; Bagci et al. 2020: no binding to inactive RAC1)
VAV3 (Movilla and Bustello 1999, Sachdev et al. 2002, Aoki et al. 2005: RAC1-directed GEF activity; M\u00fcller et al. 2020: no RAC1 directed GEF activity)
The following GEFs do not act on RAC1 or were shown to not bind to nucleotide-free RAC1 in the study by Bagci et al. 2020, as indicated:
AKAP13 (Zheng et al. 1995; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF1 (Hart et al. 1996; Jaiswal et al. 2013; Jaiswal et al. 2011; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF2 (Krendel et al. 2002; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF3 (Arthur et al. 2002; M\u00fcller et al. 2020)
ARHGEF9 (Reid et al. 1999; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ARHGEF10L (Winkler et al. 2005; M\u00fcller et al. 2020)
ARHGEF12 (Reuther et al. 2001; Jaiswal et al. 2013; Jaiswal et al. 2011; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF16 (Hiramoto Yamaki et al. 2010; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF17 (R\u00fcmenapp et al. 2002; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF26 (Ellerbroek et al. 2004; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ARHGEF28 (van Horck et al. 2001; Jaiswal et al. 2013; Jaiswal et al. 2011; M\u00fcller et al. 2020)
ARHGEF40 (Curtis et al. 2004; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
DNMBP (Jaiswal et al. 2013; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive RAC1)
ECT2L (M\u00fcller et al. 2020)
FGD1 (Olson et al. 1996; M\u00fcller et al. 2020)
FGD2 (Huber et al. 2008; M\u00fcller et al. 2020)
FGD3 (M\u00fcller et al. 2020)
FGD4 (Umikawa et al. 1999; M\u00fcller et al. 2020)
FGD6 (M\u00fcller et al. 2020)
ITSN1 (Hussain et al. 2001; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ITSN2 (M\u00fcller et al. 2020)
MCF2L2 (M\u00fcller et al. 2020)
NET1 (Alberts and Treisman 1998; M\u00fcller et al. 2020)
OBSCN (Ford Speelman et al. 2009)
PLEKHG4B (M\u00fcller et al. 2020)
PLEKHG5 (De Toledo et al. 2004; M\u00fcller et al. 2020)
PLEKHG7 (M\u00fcller et al. 2020)
RASGRF1 (M\u00fcller et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O60229-1",
"P63000-1",
"P11274-1",
"O75962-1"
],
"evidence": [
{
"id": "R-HSA-9013143",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013143"
}
]
},
{
"id": "R-HSA-9013144",
"name": "RAC1 GAPs stimulate RAC1 GTPase activity",
"equation": "",
"summary": "The following GTPase activating proteins (GAPs) were shown to bind RAC1 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RAC1:GTP complex into the inactive RAC1:GDP complex (the high throughput screen by Bagci et al. 2020 examined binding of GAPs to constitutively active RAC1 mutant without testing for activation of RAC1 GTPase activity and is cited as supporting evidence, as indicated):
ARHGAP4 (Vogt et al. 2007; M\u00fcller et al. 2020)
ARHGAP9 (Furukawa et al. 2001; M\u00fcller et al. 2020)
ARHGAP15 (Seoh et al. 2003; Zamboni et al. 2016; M\u00fcller et al. 2020)
ARHGAP20 (M\u00fcller et al. 2020)
ARHGAP22 (Mori et al. 2014; M\u00fcller et al. 2020)
ARHGAP23 (Martin Vilchez et al. 2017; M\u00fcller et al. 2020)
ARHGAP27 (Sakakibara et al. 2004; M\u00fcller et al. 2020)
ARHGAP30 (Naji et al. 2011; M\u00fcller et al. 2020)
ARHGAP31 (Tcherkezian et al. 2006; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP39 (Lundstr\u00f6m et al. 2004; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP44 (Raynaud et al. 2014; M\u00fcller et al. 2020)
CHN1 (Ahmed et al. 1994; Caloca et al. 2008; M\u00fcller et al. 2020)
CHN2 (Canagarajah et al. 2004; Caloca et al. 2003; M\u00fcller et al. 2020)
FAM13A (M\u00fcller et al. 2020)
FAM13B (M\u00fcller et al. 2020)
HMHA1 (de Kreuk et al. 2013)
RALBP1 (Jullien Flores et al. 1995; M\u00fcller et al. 2020)
SH3BP1 (M\u00fcller et al. 2020)
SRGAP2 (Mason et al. 2011; Guo and Bao 2010; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
SRGAP3 (Endris et al. 2002; M\u00fcller et al. 2020)
SYDE2 (M\u00fcller et al. 2020)
TAGAP (Bauer et al. 2005; M\u00fcller et al. 2020)
The following GAPs were shown to bind RAC1 and stimulate its GTPase activity in some but not all studies and are annotated as candidate RAC1 GAPs (the high throughput screen by Bagci et al. 2020 examined binding of GAPs to constitutively active RAC1 mutant without testing for activation of RAC1 GTPase activity and is cited as supporting evidence, as indicated):
ABR (Chuang et al. 1995, Um et al. 2014, Amin et al. 2016; M\u00fcller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARAP1 (M\u00fcller et al. 2020: RAC1-directed GAP activity; Miura et al. 2002: no RAC1-directed GAP activity)
ARAP2 (M\u00fcller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: binding to active RAC1; Yoon et al. 2006: no RAC1 directed GAP activity)
ARAP3 (Krugmann et al. 2002, M\u00fcller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP1 (Amin et al. 2016: RAC1 directed GAP activity; Li et al. 2009, Yang et al. 2006, M\u00fcller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP5 (Burbelo et al. 1995: RAC1-directed GAP activity; Bagci et al. 2020: binding to active RAC1; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
ARHGAP10 (Shibata et al. 2001: RAC1-directed GAP activity; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
ARHGAP12 (M\u00fcller et al. 2020: RAC1-directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP17 (Richnau and Aspenstrom 2001, Amin et al. 2016: RAC1 directed GAP activity; M\u00fcller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP21 (Bagci et al. 2020: binding to active RAC1; Sousa et al. 2005, M\u00fcller et al. 2020: no RAC1 directed GAP activity)
ARHGAP24 (Lavelin and Geiger 2005, Ohta et al. 2006: RAC1 directed GAP activity; Su et al. 2004, M\u00fcller et al. 2020: no RAC1 directed GAP activity)
ARHGAP25 (Cs\u00e9p\u00e1nyi K\u00f6mi et al. 2016, Cs\u00e9p\u00e1nyi K\u00f6mi et al. 2012: RAC1-directed GTPase activity; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
ARHGAP26 (Amin et al. 2016: RAC1 directed GAP activity; Sheffield et al. 1999, M\u00fcller et al. 2020: no RAC1 directed GAP activity)
ARHGAP29 (Saras et al. 1997: RAC1 directed GAP activity; M\u00fcller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP32 (Nakazawa et al. 2003: RAC1-directed GAP activity; Bagci et al. 2020: binding to active RAC1; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
ARHGAP33 (M\u00fcller et al. 2020: RAC1-directed GAP activity; Liu et al. 2006: no RAC1-directed GAP activity)
ARHGAP35 (L\u00e9vay et al. 2009, Amin et al. 2016, M\u00fcller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
ARHGAP42 (Bagci et al. 2020: binding to active RAC1; Bai et al. 2013: no RAC1 directed GAP activity)
BCR (Um et al. 2014, Chuang et al. 1995, M\u00fcller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
DEPDC1B (Wu et al. 2015: RAC1-directed GAP activity; Bagci et al. 2020: binding to active RAC1; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
DLC1 (Amin et al. 2016: RAC1 directed GAP activity; Homma and Emori 1995, M\u00fcller et al. 2020: no RAC1 directed GAP activity)
GMIP (M\u00fcller et al. 2020: RAC1-directed GAP activity; Aresta et al. 2002: no RAC1-directed GAP activity)
MYO9B (M\u00fcller et al. 2020: RAC1-directed GAP activity; Post et al. 1998, Kong et al. 2015: no RAC1-directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
OPHN1 (Niermann et al. 2016, Billuart et al. 1998, Elvers et al. 2012, Amin et al. 2016: RAC1 directed GAP activity; M\u00fcller et al. 2020: no RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
PIK3R1 (Bagci et al. 2020: binding to active RAC1; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
PIK3R2 (Bagci et al. 2020: binding to active RAC1; M\u00fcller et al. 2020: no RAC1-directed GAP activity)
RACGAP1 (Tour\u00e9 et al. 1998, Amin et al. 2016, M\u00fcller et al. 2020: RAC1 directed GAP activity; Bagci et al. 2020: no binding to active RAC1)
SRGAP1 (M\u00fcller et al. 2020: RAC1-directed GAP activity; Wong et al. 2001: no RAC1-directed GAP activity)
The following GAPs do not act on RAC1 or were shown by Bagci et al. 2020 to not bind constitutively active RAC1 mutant, as indicated:
ARHGAP6 (Prakash et al. 2000; M\u00fcller et al. 2020)
ARHGAP8 (Lua and Low 2004; M\u00fcller et al. 2020)
ARHGAP11A (Lawson et al. 2016; M\u00fcller et al. 2020)
ARHGAP11B (Florio et al. 2015; M\u00fcller et al. 2020)
ARHGAP18 (Maeda et al. 2011; M\u00fcller et al. 2020)
ARHGAP19 (David et al. 2014; M\u00fcller et al. 2020)
ARHGAP28 (Yeung et al. 2014; M\u00fcller et al. 2020)
ARHGAP36 (Rack et al. 2014; M\u00fcller et al. 2020)
ARHGAP40 (M\u00fcller et al. 2020)
ARHGAP45 (M\u00fcller et al. 2020)
DEPDC1 (M\u00fcller et al. 2020)
INPP5B (M\u00fcller et al. 2020)
MYO9A (M\u00fcller et al. 2020; Bagci et al. 2020: no binding to active RAC1)
OCRL (Erdmann et al. 2007; Lichter Konecki et al. 2006; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to active RAC1)
STARD8 (Kawai et al. 2007; Amin et al. 2016; M\u00fcller et al. 2020)
STARD13 (Ching et al. 2003; Amin et al. 2016; M\u00fcller et al. 2020)
SYDE1 (M\u00fcller et al. 2020; Bagci et al. 2020: no binding to active RAC1)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q15311-1",
"P63000-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-9013144",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013144"
}
]
},
{
"id": "R-HSA-9013159",
"name": "CDC42 GEFs activate CDC42",
"equation": "",
"summary": "The following guanine nucleotide exchange factors (GEFs) were shown to bind CDC42 and catalyze GDP to GTP exchange on CDC42, resulting in formation of the active CDC42:GTP complex (the high throughput study by Bagci et al. 2020 examined binding of GEFs to inactive CDC42 mutants without testing for CDC42-directed GEF activity and is cited as supporting evidence):
ARHGEF4 (also known as Asef) (Itoh et al. 2008; Anderson and Hamann 2012; Gotthardt and Ahmadian 2007; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ARHGEF9 (also known as hPEM2) (Reid et al. 1999; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ARHGEF15 (Fukushima et al. 2016; M\u00fcller et al. 2020)
DEF6 (Mavrakis et al. 2004)
DNMBP (also known as Tuba) (Salazar et al. 2003; Jaiswal et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
FGD1 (Olson et al. 1996; M\u00fcller et al. 2020)
FGD2 (Huber et al. 2008; M\u00fcller et al. 2020)
FGD3 (Hayakawa et al. 2008; M\u00fcller et al. 2020)
FGD4 (Umikawa et al. 1999; M\u00fcller et al. 2020)
MCF2 (Ueda et al. 2004; Jaiswal et al. 2013; M\u00fcller et al. 2020)
MCF2L (Ueda et al. 2004; Whitehead et al. 1999; Jaiswal et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
PLEKHG1 (Abiko et al. 2015; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
PLEKHG3 (Nguyen et al. 2016; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
PLEKHG4 (Gupta et al. 2013; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
PLEKHG4B (M\u00fcller et al. 2020)
SPATA13 (Hamann et al. 2007; Kawasaki et al. 2007; Bristow et al. 2009; M\u00fcller et al. 2020)
The following GEFs; annotated as CDC42 candidate GEFs; were shown to activate CDC42 by some but not all studies (the high throughput study by Bagci et al. 2020 examined binding of GEFs to inactive CDC42 mutants without testing for CDC42-directed GEF activity and is cited as supporting evidence):
ABR (Chuang et al. 1995: CDC42-directed GEF activity; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
ARHGEF5 (Xie et al. 2005: CDC42 directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF6 (also known as alphaPIX or KIAA006) (Manser et al. 1998, Ramakers et al. 2012, Meseke et al. 2013: CDC42-directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity)
ARHGEF10 (M\u00fcller et al. 2020: CDC42 directed GEF activity; Mohl et al. 2006: no CDC42-directed GEF activity)
ARHGEF11 (Bagci et al. 2020: binding to inactive CDC42; R\u00fcmenapp et al. 1999, Jaiswal et al. 2011, Jaiswal et al. 2013, M\u00fcller et al. 2020: no CDC42 directed GEF activity)
ARHGEF12 (Bagci et al. 2020: binding to inactive CDC42; Reuther et al. 2001, Jaiswal et al. 2011, Jaiswal et al. 2013, M\u00fcller et al. 2020: no CDC42 directed GEF activity)
ARHGEF16 (Bagci et al. 2020: binding to inactive CDC42; Hiramoto Yamaki et al. 2010, M\u00fcller et al. 2020: no CDC42 directed GEF activity)
ARHGEF19 (Wang et al. 2004: CDC42-directed GEF activity; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
ARHGEF25 (Guo et al. 2003: CDC42-directed GEF activity; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
ARHGEF26 (M\u00fcller et al. 2020: CDC42 directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; Ellerbroek et al. 2004: no CDC42 directed GEF activity)
BCR (Chuang et al. 1995; Korus et al. 2002: CDC42 directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
DOCK6 (Miyamoto et al. 2007: CDC42 directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
DOCK7 (Kukimoto Niino et al. 2019, Wilkes et al. 2014, Zhou et al. 2013, Yamauchi et al. 2008: CDC42-directed GEF activity; M\u00fcller et al. 2020: no CDC42-directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
DOCK8 (Ruusala and Aspenstrom 2004, Harada et al. 2012, Martins et al. 2016, Xu et al. 2017: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
DOCK9 (also known as Zizimin1) (Meller et al. 2002, Cote and Vuori 2002, Kulkarni et al. 2011: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
DOCK10 (Gadea et al. 2008, Ruiz Lafuente et al. 2015: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
DOCK11 (Lin et al. 2006: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
ECT2 (Tatsumoto et al. 1999, Fortin et al. 2012: CDC42 directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
FARP1 (Amado Azevedo et al. 2017: CDC42 directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
GNA13 (Yan et al. 2015: GNA13 increases the amount of GTP-bound CDC42, but the evidence for direct effect is lacking)
ITSN1 (Hussain et al. 2001, Jaiswal et al. 2013: CDC42-directed GEF activity; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
NGEF (Zhang et al. 2007: CDC42 directed GEF activity; M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
PLEKHG2 (Ueda et al. 2008: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; M\u00fcller et al. 2020: no CDC42-directed GEF activity)
PREX1 (Jaiswal et al. 2013: CDC42 directed GEF activity; Marei et al. 2016, M\u00fcller et al. 2020: no CDC42 directed GEF activity)
PREX2 (M\u00fcller et al. 2020: CDC42-directed GEF activity; Joseph and Norris 2005: no CDC42-directed GEF activity)
RASGRF2 (M\u00fcller et al. 2020: CDC42-directed GEF activity; Calvo et al. 2011: no CDC42-directed GEF activity)
TIAM1 (Michiels et al. 1995: CDC42 directed GEF activity; Itoh et al. 2008, Jaiswal et al. 2013, M\u00fcller et al. 2020: no CDC42 directed GEF activity; Bagci et al. 2020: no binding to inactive CDC42)
TRIO (Peurois et al. 2017, Fortin et al. 2012, Jaiswal et al. 2013: CDC42 directed GEF activity, the presence of membrane may be necessary; Debant et al. 1996: no CDC42-directed GEF activity of either the N-terminal GEF1 domain or the C-terminal GEF2 domain of TRIO in vitro; M\u00fcller et al. 2020: no CDC42 directed GEF activity of the full-length TRIO; Bagci et al. 2020: no binding of full-length TRIO to inactive CDC42)
VAV2 (Itoh et al. 2008, Aoki et al. 2005, Heo et al. 2005, Jaiswal et al. 2013: CDC42-directed GEF activity; Bagci et al. 2020: binding to inactive CDC42; M\u00fcller et al. 2020: no CDC42 directed GEF activity)
VAV3 (Sachdev et al. 2002; Aoki et al. 2005: CDC42 directed GEF activity; Movilla and Bustelo 1999, M\u00fcller et al. 2020: no CDC42 directed GEF activity)
The following GEFs do not act on CDC42 or were shown to not bind to inactive CDC42 mutant in the high throughput screen by Bagci et al. 2020):
AKAP13 (Zheng et al. 1995; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ALS2 (M\u00fcller et al. 2020)
ARHGEF1 (Hart et al. 1996; Jaiswal et al. 2013; Jaiswal et al. 2011; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF2 (Krendel et al. 2002; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF3 (Arthur et al. 2002; M\u00fcller et al. 2020)
ARHGEF7 (Manser et al. 1998; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF10L (Winkler et al. 2005; M\u00fcller et al. 2020)
ARHGEF17 (R\u00fcmenapp et al. 2002; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ARHGEF18 (Niu et al. 2003; Blomquist et al. 2000; M\u00fcller et al. 2020)
ARHGEF28 (van Horck et al. 2001; Jaiswal et al. 2011; Jaiswal et al. 2013; M\u00fcller et al. 2020)
ARHGEF39 (M\u00fcller et al. 2020)
ARHGEF40 (Curtis et al. 2004; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
DOCK1 (Cote and Vuori 2002; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
DOCK2 (Kulkarni et al. 2011; Kwofie and Skowronski 2008; M\u00fcller et al. 2020)
DOCK3 (Kwofie and Skowronski 2008; M\u00fcller et al. 2020)
DOCK4 (Kwofie and Skowronski 2008; Abraham et al. 2015; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
DOCK5 (Vives et al. 2011; M\u00fcller et al. 2020; Bagci et al. 2020: no binding to inactive CDC42)
ECT2L (M\u00fcller et al. 2020)
FARP2 (Kubo et al. 2002; M\u00fcller et al. 2020)
FGD5 (M\u00fcller et al. 2020)
FGD6 (M\u00fcller et al. 2020)
ITSN2 (M\u00fcller et al. 2020)
KALRN (Penzes et al. 2001; M\u00fcller et al. 2020)
MCF2L2 (M\u00fcller et al. 2020)
NET1 (Alberts and Treisman 1998; M\u00fcller et al. 2020)
OBSCN (Ford Speelman et al. 2009)
PLEKHG5 (De Toledo et al. 2001; M\u00fcller et al. 2020)
PLEKHG6 (M\u00fcller et al. 2020)
PLEKHG7 (M\u00fcller et al. 2020)
RASGRF1 (M\u00fcller et al. 2020)
SOS1 (Nimnual et al. 1998; M\u00fcller et al. 2020)
SOS2 (Nimnual et al. 1998; M\u00fcller et al. 2020)
SWAP70 (Bagci et al. 2020: no binding to inactive CDC42)
TIAM2 (M\u00fcller et al. 2020)
VAV1 (Aghazadeh et al. 2000; M\u00fcller et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P60953-2",
"P11274-1",
"O75962-1"
],
"evidence": [
{
"id": "R-HSA-9013159",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013159"
}
]
},
{
"id": "R-HSA-9013161",
"name": "CDC42 GAPs stimulate CDC42 GTPase activity",
"equation": "",
"summary": "The following GTPase activating proteins (GAPs) were shown to bind CDC42 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active CDC42:GTP complex into the inactive CDC42:GDP complex (the high throughput screen by Bagci et al. 2020 is cited as supporting evidence since it examined binding of GAPs to constitutively active CDC42 mutant but did not test for activation of CDC42 GTPase activity):
ARAP1 (Miura et al. 2002; M\u00fcller et al. 2020)
ARHGAP1 (Nassar et al. 1998; Amin et al. 2016; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP20 (M\u00fcller et al. 2020)
ARHGAP22 (Mori et al. 2014; M\u00fcller et al. 2020)
ARHGAP39 (Lundstr\u00f6m et al. 2004; M\u00fcller et al. 2020; supported by Bagci et al. 2020)
ARHGAP40 (M\u00fcller et al. 2020)
FAM13B (M\u00fcller et al. 2020)
HMHA1 (de Kreuk et al. 2013)
The following GAPs were shown to bind CDC42 and stimulate its GTPase activity in some but not all studies and are annotated as candidate CDC42 GAPs:
ABR (Chuang et al. 1995, Amin et al. 2016: CDC42 directed GAP activity; M\u00fcller et al. 2020: no CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42 GAP)
ARAP2 (M\u00fcller et al. 2020: CDC42-directed GAP activity; Yoon et al. 2006: no CDC42-directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
ARAP3 (Krugmann et al. 2002, M\u00fcller et al. 2020: CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
ARHGAP4 (Vogt et al. 2007: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP5 (Burbelo et al. 1995: CDC42-directed GAP activity; Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP9 (Furukawa et al. 2001: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP10 (also known as Graf2) (Shibata et al. 2001: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP11B (M\u00fcller et al. 2020: CDC42-directed GAP activity; Florio et al. 2015: no CDC42-directed GAP activity)
ARHGAP17 (Richnau and Aspenstrom 2001, Amin et al. 2016: CDC42-directed GAP activity; Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP21 (Sousa et al. 2005: CDC42 directed GAP activity; Bagci et al. 2020: binding to active CDC42; Lazarini et al. 2013, M\u00fcller et al. 2020: no CDC42 directed GAP activity)
ARHGAP24 (Lavelin and Geiger 2005, Ohta et al. 2006: CDC42 directed GAP activity; Su et al. 2004, M\u00fcller et al. 2020: no CDC42 directed GAP activity)
ARHGAP26 (Hildebrand 1996, Sheffield et al. 1999, Amin et al. 2016: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP27 (Sakakibara et al. 2004: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP29 (Saras et al. 1997: CDC42 directed GAP activity; M\u00fcller et al. 2020: no CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
ARHGAP30 (M\u00fcller et al. 2020: CDC42-directed GAP activity; Naji et al. 2011: no CDC42-directed GAP activity)
ARHGAP31 (Tcherkezian et al. 2006, M\u00fcller et al. 2020: CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
ARHGAP32 (Nakazawa et al. 2003: CDC42-directed GAP activity; Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP33 (Chiang et al. 2003, Liu et al. 2006: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
ARHGAP35 (Zhang et al. 1997, Amin et al. 2016: CDC42 directed GAP activity; M\u00fcller et al. 2020: no CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
ARHGAP42 (Bai et al. 2013: CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
ARHGAP44 (also known as RICH2) (Raynaud et al. 2014: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
BCR (Chuang et al. 1995: CDC42 directed GAP activity; M\u00fcller et al. 2020: no CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
CHN1 (also known as ARHGAP2) (Ahmed et al. 1994: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
DEPDC1B (Bagci et al. 2020: binding to active CDC42; Wu et al. 2015, M\u00fcller et al. 2020: no CDC42 directed GAP activity)
DLC1 (Healy et al. 2008, Kim et al. 2008, Amin et al. 2016: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
GMIP (M\u00fcller et al. 2020: CDC42-directed GAP activity; Aresta et al. 2002: no CDC42-directed GAP activity)
MYO9B (M\u00fcller et al. 2020: CDC42-directed GAP activity; Post et al. 1998, Kong et al. 2015: no CDC42-directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
OPHN1 (Elvers et al. 2012, Amin et al. 2016: CDC42-directed GAP activity; Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
PIK3R1 (Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
PIK3R2 (Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
RACGAP1 (Tour\u00e9 et al. 1998, Amin et al. 2016: CDC42 directed GAP activity; M\u00fcller et al. 2020: no CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
RALBP1 (Jullien Flores et al. 1995: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
SRGAP1 (Wong et al. 2001: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
SRGAP2 (Mason et al. 2011, M\u00fcller et al. 2020: CDC42 directed GAP activity; Bagci et al. 2020: no binding to active CDC42)
SRGAP3 (Endris et al. 2002: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
STARD8 (Kawai et al. 2007, M\u00fcller et al. 2020: CDC42 directed GAP activity; Amin et al. 2016: no CDC42 directed GAP activity)
STARD13 (Leung et al. 2005, Ching et al. 2003: CDC42 directed GAP activity; Amin et al. 2016, M\u00fcller et al. 2020: no CDC42 directed GAP activity)
SYDE1 (Amado Azevedo et al. 2017: CDC42-directed GAP activity; Bagci et al. 2020: binding to active CDC42; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
TAGAP (Bauer et al. 2005: CDC42-directed GAP activity; M\u00fcller et al. 2020: no CDC42-directed GAP activity)
The following GAPs do not act on CDC42 or were shown in the high throughput screen by Bagci et al. 2020 to not bind to constitutively active CDC42 mutant:
ARHGAP6 (Prakash et al. 2000; M\u00fcller et al. 2020)
ARHGAP8 (Lua and Low 2004; M\u00fcller et al. 2020)
ARHGAP11A (Lawson et al. 2016; M\u00fcller et al. 2020)
ARHGAP12 (Bagci et al. 2020; M\u00fcller et al. 2020)
ARHGAP15 (Seoh et al. 2003; M\u00fcller et al. 2020)
ARHGAP18 (Maeda et al. 2011; M\u00fcller et al. 2020)
ARHGAP19 (David et al. 2014; M\u00fcller et al. 2020)
ARHGAP23 (M\u00fcller et al. 2020)
ARHGAP25 (Cs\u00e9p\u00e1nyi K\u00f6mi et al. 2012; M\u00fcller et al. 2020)
ARHGAP28 (Yeung et al. 2014; M\u00fcller et al. 2020)
ARHGAP36 (Rack et al. 2014; M\u00fcller et al. 2020; ARHGAP36 was shown by Jelen et al. 2009 to lack motifs needed for the GAP activity and likely does not act like a GAP)
ARHGAP45 (M\u00fcller et al. 2020)
CHN2 (Caloca et al. 2003; M\u00fcller et al. 2020)
DEPDC1 (M\u00fcller et al. 2020)
FAM13A (M\u00fcller et al. 2020)
INPP5B (M\u00fcller et al. 2020)
MYO9A (M\u00fcller et al. 2020; Bagci et al. 2020)
OCRL (Erdmann et al. 2007; Lichter Konecki et al. 2006; M\u00fcller et al. 2020; Bagci et al. 2020)
SH3BP1 (M\u00fcller et al. 2020)
SYDE2 (M\u00fcller et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P60953-2",
"Q15311-1",
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-9013161",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013161"
}
]
},
{
"id": "R-HSA-9014295",
"name": "RAC2 GAPs stimulate RAC2 GTPase activity",
"equation": "",
"summary": "The following GTPase -activating proteins (GAPs) were shown to bind RAC2 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RAC2:GTP complex into the inactive RAC2:GDP complex (the high throughput study by Bagci et al. 2020 is cited as supporting evidence, because it examined binding of GAPs to constitutively active RAC2 mutant but did not examine GAP-mediated activation of RAC2 GTPase activity):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP35 (Amin et al. 2016; Bagci et al. 2020)
The following GAPs, annotated as candidate RAC2 GAPs, were shown to bind RAC2 and stimulate its GTPase activity in some but not all studies or were shown to bind to constitutively active RAC2 mutant (Bagci et al. 2020) but their ability to activate RAC2 GTPase activity has not been tested:
ABR (Chuang et al. 1995: RAC2 directed GAP activity; Amin et al. 2016: no RAC2 directed GAP activity; Bagci et al. 2020: no binding t active RAC2)
ARHGAP17 (Amin et al. 2016: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
ARHGAP21 (Bagci et al. 2020: binding to active RAC2)
ARHGAP32 (Bagci et al. 2020: binding to active RAC2)
ARHGAP39 (Bagci et al. 2020: binding to active RAC2)
ARHGAP42 (Bagci et al. 2020: binding to active RAC2)
BCR (Chuang et al. 1995: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
DEPDC1B (Bagci et al. 2020)
OPHN1 (Amin et al. 2016: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
PIK3R1 (Bagci et al. 2020: binding to active RAC2)
PIK3R2 (Bagci et al. 2020: binding to active RAC2)
RACGAP1 (Amin et al. 2016: RAC2 directed GAP activity; Bagci et al. 2020: no binding to active RAC2)
SYDE1 (Bagci et al. 2020: binding to active RAC2)
The following GAPs do not act on RAC2 or were shown by Bagci et al. 2020 to not bind to active RAC2:
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP5 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD8 (Amin et al. 2016)
STARD13 (Amin et al. 2016)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1"
],
"evidence": [
{
"id": "R-HSA-9014295",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9014295"
}
]
},
{
"id": "R-HSA-9014296",
"name": "RAC2 GEFs activate RAC2",
"equation": "",
"summary": "The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC2 and catalyze GDP to GTP exchange on RAC2, resulting in formation of the active RAC2:GTP complex:
ABR (Chuang et al. 1995)
BCR (Chuang et al. 1995)
DEF6 (Mavrakis et al. 2004)
DOCK2 (Sai et al. 2008; Kwofie and Skowronski 2008 )
MCF2 (Jaiswal et al. 2013)
PREX1 (Welch et al. 2005; Dong et al. 2005; Barber et al. 2007; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003; Niebel et al. 2013; Jaiswal et al. 2013)
TRIO (Newsome et al. 2000; Hakeda-Suzuki et al. 2002; Jaiswal et al. 2013)
VAV1 (Ming et al. 2007; Miletic et al. 2007; Yin et al. 2011)
VAV2 (Arana et al. 2008; Jaiswal et al. 2013)
VAV3 (Flannagan et al. 2014)
The following GEFs are annotated as candidate RAC2 GEFs since they were shown to bind RAC2, but their ability to activate RAC2 has not been tested:
DOCK1 (Kwofie and Skowronski 2008)
DOCK3 (Kwofie and Skowronski 2008)
DOCK4 (Kwofie and Skowronski 2008)
DOCK10 (Ruiz-Lafuente et al. 2015)
SWAP70 (Sivalenka and Jessberger 2004)
The following RHO GEFs do not act on RAC2:
ARHGEF1 (Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2013)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF4 (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
DOCK9: (Kwofie and Skowronski 2008)
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11274-1",
"O75962-1"
],
"evidence": [
{
"id": "R-HSA-9014296",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9014296"
}
]
},
{
"id": "R-HSA-9018806",
"name": "RAC3 GAPs stimulate RAC3 GTPase activity",
"equation": "",
"summary": "The following GTPase activating proteins (GAPs) were shown to bind RAC3 and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RAC3:GTP complex into the inactive RAC3:GDP complex (the high throughput screen by Bagci et al. 2020, cited as supporting evidence, examined binding of GAPs to constitutively active RAC3 mutant without looking at activation of the RAC3 GTPase activity):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP6 (Li et al. 2016)
ARHGAP15 (Zamboni et al. 2016)
ARHGAP26 (Amin et al. 2016)
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
The following GAPs, annotated as candidate RAC3 GAPs, were shown to bind RAC3 and stimulate its GTPase activity in some but not all studies or were shown to bind to the constitutively active RAC3 mutant without testing for activation of RAC3 GTPase activity, as indicated:
ABR (Amin et al. 2016: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
ARAP2 (Bagci et al. 2020: binding to active RAC3)
ARAP3 (Bagci et al. 2020: binding to active RAC3)
ARHGAP5 (Bagci et al. 2020: binding to active RAC3)
ARHGAP17 (Amin et al. 2016: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
ARHGAP21 (Bagci et al. 2020: binding to active RAC3)
ARHGAP32 (Bagci et al. 2020: binding to active RAC3)
ARHGAP39 (Bagci et al. 2020: binding to active RAC3)
ARHGAP42 (Bagci et al. 2020: binding to active RAC3)
BCR (Haataja et al. 1997: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
DEPDC1B (Bagci et al. 2020: binding to active RAC3)
OCRL (Bagci et al. 2020: binding to active RAC3; Erdmann et al. 2007; Lichter Konecki et al. 2006: no RAC3 directed GAP activity:)
OPHN1 (Amin et al. 2016: RAC3 directed GAP activity; Bagci et al. 2020: no binding to active RAC3)
PIK3R1 (Bagci et al. 2020: binding to active RAC3)
PIK3R2 (Bagci et al. 2020: binding to active RAC3)
SRGAP2 (Bagci et al. 2020: binding to active RAC3)
SYDE1 (Bagci et al. 2020: binding to active RAC3)
The following GAPs have been shown to not act on RAC3 or were shown to not bind to the constitutively active RAC3 mutant by Bagci et al. 2020:
ARHGAP12 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P60763-1",
"P11274-1",
"Q01968-1"
],
"evidence": [
{
"id": "R-HSA-9018806",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018806"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "A0A087WRH8",
"gene_name": "Gm5157",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A087WRH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WRH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A087WRH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WRH8"
}
]
}
]
},
{
"uniprot_ac": "A0A087WSA6",
"gene_name": "Gm7358",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
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}
]
},
{
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]
},
{
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}
]
},
{
"ec_number": "2.3.1.48",
"activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].",
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{
"id": "Q00972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00972"
}
]
},
{
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}
]
}
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},
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{
"ec_number": "2.7.11.1",
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}
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},
{
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}
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}
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}
]
},
{
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}
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}
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},
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},
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]
},
{
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]
},
{
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]
}
]
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},
{
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]
}
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]
},
{
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]
}
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},
{
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]
}
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},
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]
}
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},
{
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}
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]
},
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]
}
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},
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},
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}
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},
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}
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},
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}
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]
},
{
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]
},
{
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]
},
{
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]
},
{
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},
{
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]
}
]
},
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]
},
{
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]
}
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},
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{
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]
},
{
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]
}
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},
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{
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]
},
{
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}
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},
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{
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}
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]
},
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]
}
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},
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]
},
{
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]
}
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{
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]
},
{
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]
},
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}
]
}
]
},
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{
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]
},
{
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]
}
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},
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]
},
{
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]
}
]
},
{
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{
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}
]
},
{
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]
}
]
},
{
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{
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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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}
]
},
{
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]
}
]
},
{
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{
"ec_number": "2.7.11.1",
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]
},
{
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]
},
{
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]
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"ec_number": "2.7.11.25",
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},
{
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},
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}
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{
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}
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}
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}
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},
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{
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{
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}
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},
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}
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},
{
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},
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}
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}
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}
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}
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},
{
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},
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},
{
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}
]
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]
},
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]
},
{
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]
}
]
},
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]
},
{
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]
},
{
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]
},
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]
}
]
},
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]
},
{
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]
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]
},
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]
},
{
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{
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{
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{
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]
},
{
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]
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}
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},
{
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}
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}
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}
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{
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},
{
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}
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}
]
},
{
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}
]
}
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},
{
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}
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}
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]
},
{
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}
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}
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},
{
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}
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},
{
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{
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}
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},
{
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}
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{
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},
{
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}
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}
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}
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]
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{
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{
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]
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{
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]
},
{
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]
}
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{
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]
},
{
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},
{
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{
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},
{
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},
{
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},
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{
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{
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]
},
{
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]
},
{
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]
},
{
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]
},
{
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]
},
{
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