{ "uniprot_canonical_ac": "P11217-1", "uniprot_ac": "P11217", "uniprot_id": "PYGM_HUMAN", "mass": { "chemical_mass": 97092.0, "monoisotopic_mass": 97092.0 }, "refseq": { "ac": "NP_001158188", "name": "glycogen phosphorylase, muscle form isoform 2", "summary": "This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" }, "gene_names": [ { "name": "PYGM", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11217", "id": "P11217" }, { "name": "GSD5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188", "id": "NP_001158188" }, { "name": "PYGM", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188", "id": "NP_001158188" } ], "protein_names": [ { "name": "Glycogen phosphorylase, muscle form", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11217" }, { "name": "2.4.1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11217" }, { "name": "Myophosphorylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11217" }, { "name": "glycogen phosphorylase, muscle form isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188", "id": "NP_001158188" }, { "name": "myophosphorylase; glycogen phosphorylase, muscle form; phosphorylase, glycogen, muscle", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188", "id": "NP_001158188" } ], "function": [ { "annotation": "A New Glycogen Storage Disease Caused by a Dominant PYGM Mutation.", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" }, { "database": "PubMed", "id": "32386344", "url": "https://glygen.org/publication/PubMed/32386344" } ] }, { "annotation": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217#function" }, { "database": "PubMed", "id": "8316268", "url": "https://glygen.org/publication/PubMed/8316268" } ] }, { "annotation": "Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" }, { "database": "PubMed", "id": "33924466", "url": "https://glygen.org/publication/PubMed/33924466" } ] }, { "annotation": "PYGM mRNA expression in McArdle disease: Demographic, clinical, morphological and genetic features. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" }, { "database": "PubMed", "id": "32735634", "url": "https://glygen.org/publication/PubMed/32735634" } ] }, { "annotation": "This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" } ] }, { "annotation": "Whole-exome sequencing detects PYGM variants in two adults with McArdle disease. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" }, { "database": "PubMed", "id": "35022222", "url": "https://glygen.org/publication/PubMed/35022222" } ] } ], "disease": [ { "disease_id": "DOID:2746", "recommended_name": { "id": "DOID:2746", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2746", "name": "glycogen storage disease V", "description": "A glycogen storage disease that is characterized by onset of exercise intolerance and muscle cramps in childhood or adolescence and that has_material_basis_in homozygous or compound heterozygous mutation in the PYGM gene, which encodes muscle glycogen phosphorylase, on chromosome 11q13." }, "synonyms": [ { "id": "DOID:2746", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2746", "name": "Glycogen storage disease 5", "description": "" }, { "id": "DOID:2746", "resource": "Disease 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hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P11217", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11217" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "common_name": "Human" } ], "gene": [ { "name": "PYGM", "url": "https://www.uniprot.org/uniprot/P11217", "locus": { "chromosome": "11", "start_pos": 64746389, "end_pos": 64759974, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000068976", "url": "https://www.ensembl.org/id/ENSG00000068976" } ] } } ], "crossref": [ { "id": "ENSG00000068976", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000068976", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P11217", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11217", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "GT35", "url": "http://www.cazy.org/GT35.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "cd04300", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04300", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3526", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3526", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "PYGM", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PYGM", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "5837", "url": "https://www.ncbi.nlm.nih.gov/gene/5837", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9726", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9726", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P11217", "url": "https://www.ebi.ac.uk/intact/interactors/id:P11217*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:5837", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5837", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "232600", "url": "http://www.omim.org/entry/232600", "database": "MIM", "categories": [ "Other" ] }, { "id": "608455", "url": "http://www.omim.org/entry/608455", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P11217", "url": "https://www.nextprot.org/entry/NX_P11217", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P11217", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11217", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "IYDINWR", "url": "https://omabrowser.org/oma/group/IYDINWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5473321at2759", "url": "http://www.orthodb.org/?query=5473321at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11468", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11468", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11468:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11468:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1Z8D", "url": "https://www.rcsb.org/structure/1Z8D", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00343", "url": "http://pfam.xfam.org/family/PF00343", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P11217", "url": "https://pharos.nih.gov/targets/P11217", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P11217", "url": "http://purl.obolibrary.org/obo/PR_P11217", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "41732", "url": "https://www.rhea-db.org/rhea/41732", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11217-1", "url": "https://www.uniprot.org/uniprot/P11217-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11217-2", "url": "https://www.uniprot.org/uniprot/P11217-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI", "length": 842, "header": "sp|P11217-1|PYGM_HUMAN Isoform 1 of Glycogen phosphorylase, muscle form OS=Homo sapiens OX=9606 GN=PYGM PE=1 SV=6 CANONICAL=P11217-1" }, "isoforms": [ { "isoform_ac": "P11217-1", "url": "", "sequence": { "sequence": "MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI", "length": 842, "header": "sp|P11217-1|PYGM_HUMAN Isoform 1 of Glycogen phosphorylase, muscle form OS=Homo sapiens OX=9606 GN=PYGM PE=1 SV=6 CANONICAL=P11217-1" }, "locus": { "chromosome": "11", "start_pos": 64759898, "end_pos": 64746662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000164139.4", "url": "https://www.ensembl.org/id/ENST00000164139.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000164139.3", "url": "https://www.ensembl.org/id/ENSP00000164139.3" } ] } }, { "isoform_ac": "P11217-2", "url": "", "sequence": { "sequence": "MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI", "length": 754, "header": "sp|P11217-2|PYGM_HUMAN Isoform 2 of Glycogen phosphorylase, muscle form OS=Homo sapiens OX=9606 GN=PYGM PE=1 SV=6 CANONICAL=P11217-1" }, "locus": { "chromosome": "11", "start_pos": 64759898, "end_pos": 64746662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000377432.7", "url": "https://www.ensembl.org/id/ENST00000377432.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000366650.3", "url": "https://www.ensembl.org/id/ENSP00000366650.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P11217", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11217" }, { "id": "18984734", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18984734" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" } ] } ], "phosphorylation": [ { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "P15735-1", "kinase_gene_name": "PHKG2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11217", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11217" }, { "database": "PubMed", "id": "22225877", "url": "https://glygen.org/publication/PubMed/22225877" } ], "site_lbl": "Ser15" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "Q16816-1", "kinase_gene_name": "PHKG1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11217", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11217" }, { "database": "PubMed", "id": "22225877", "url": "https://glygen.org/publication/PubMed/22225877" } ], "site_lbl": "Ser15" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PHK; in form phosphorylase A", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" }, { "database": "iPTMnet", "id": "P11217", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11217" }, { "database": "PubMed", "id": "16083285", "url": "https://glygen.org/publication/PubMed/16083285" }, { "database": "phospho.ELM", "id": "P11217", "url": "http://phospho.elm.eu.org/byAccession/P11217.html" }, { "database": "PubMed", "id": "1140412", "url": "https://glygen.org/publication/PubMed/1140412" }, { "database": "PubMed", "id": "1150650", "url": "https://glygen.org/publication/PubMed/1150650" } ], "site_lbl": "Ser15" }, { "start_pos": 204, "end_pos": 204, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Tyr204" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Tyr227" }, { "start_pos": 430, "end_pos": 430, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Ser430" }, { "start_pos": 473, "end_pos": 473, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Tyr473" }, { "start_pos": 514, "end_pos": 514, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Ser514" }, { "start_pos": 747, "end_pos": 747, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Ser747" }, { "start_pos": 748, "end_pos": 748, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "site_lbl": "Ser748" } ], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A new mutation in the myophosphorylase gene (Asn684Tyr) in a Spanish patient with McArdle's disease.", "journal": "Neuromuscular disorders : NMD", "date": "1999", "authors": "Andreu AL, Bruno C, Tamburino L, Gamez J, Shanske S, Cervera C, Navarro C, DiMauro S", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10382911", "url": "https://glygen.org/publication/PubMed/10382911" } ] }, { "title": "McArdle's disease associated with homozygosity for the missense mutation Gly204Ser of the myophosphorylase gene in a Spanish patient.", "journal": "Neuromuscular disorders : NMD", "date": "1999", "authors": "Rubio JC, Martin MA, Garcia A, Campos Y, Cabello A, Culebras JM, Arenas J", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10382912", "url": "https://glygen.org/publication/PubMed/10382912" } ] }, { "title": "A new mutation in the regulatory domain of the myophosphorylase gene affecting protein dimer contact.", "journal": "Muscle & nerve", "date": "1999", "authors": "Gamez J, Fernandez R, Bruno C, Andreu AL, Cervera C, Navarro C, Schwartz S, Dimauro S", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10417800", "url": "https://glygen.org/publication/PubMed/10417800" } ] }, { "title": "Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure.", "journal": "Frontiers in bioscience : a journal and virtual library", "date": "1999", "authors": "Brushia RJ, Walsh DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "10487978", "url": "https://glygen.org/publication/PubMed/10487978" } ] }, { "title": "A missense mutation W797R in the myophosphorylase gene in a Spanish patient with McArdle's disease.", "journal": "Muscle & nerve", "date": "2000", "authors": "Rubio JC, Martin MA, Campos Y, Auciello R, Cabello A, Arenas J", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10590419", "url": "https://glygen.org/publication/PubMed/10590419" } ] }, { "title": "A novel missense mutation (W797R) in the myophosphorylase gene in Spanish patients with McArdle disease.", "journal": "Archives of neurology", "date": "2000", "authors": "Fernandez R, Navarro C, Andreu AL, Bruno C, Shanske S, Gamez J, Teijeira S, Hernandez I, Teijeiro A, Fernandez JM, Musumeci O, DiMauro S", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10681080", "url": "https://glygen.org/publication/PubMed/10681080" } ] }, { "title": "A missense mutation T487N in the myophosphorylase gene in a Spanish patient with McArdle's disease.", "journal": "Neuromuscular disorders : NMD", "date": "2000", "authors": "Rubio JC, Martin MA, Campos Y, Cabello A, Arenas J", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10714589", "url": "https://glygen.org/publication/PubMed/10714589" } ] }, { "title": "A homozygous missense mutation (A659D) in the myophosphorylase gene in a Spanish patient with McArdle's disease.", "journal": "Neuromuscular disorders : NMD", "date": "2000", "authors": "Martin MA, Rubio JC, Campos Y, Ricoy JR, Cabello A, Arenas J", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "10899452", "url": "https://glygen.org/publication/PubMed/10899452" } ] }, { "title": "Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core.", "journal": "Molecular cell", "date": "2000", "authors": "Rath VL, Ammirati M, LeMotte PK, Fennell KF, Mansour MN, Danley DE, Hynes TR, Schulte GK, Wasilko DJ, Pandit J", "evidence": [ { 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Role of the peptide region surrounding the phosphoserine residue in determining enzyme properties.", "journal": "The Journal of biological chemistry", "date": "1975", "authors": "Carty TJ, Tu J-I, Graves DJ", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" }, { "database": "iPTMnet", "id": "P11217", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11217" } ], "reference": [ { "type": "PubMed", "id": "1150650", "url": "https://glygen.org/publication/PubMed/1150650" } ] }, { "title": "Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study.", "journal": "Annals of neurology", "date": "2001", "authors": "Martin MA, Rubio JC, Buchbinder J, Fernandez-Hojas R, del Hoyo P, Teijeira S, Gamez J, Navarro C, Fernandez JM, Cabello A, Campos Y, Cervera C, Culebras JM, Andreu AL, Fletterick R, Arenas J", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": 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"id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "16523484", "url": "https://glygen.org/publication/PubMed/16523484" } ] }, { "title": "Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes.", "journal": "Diabetes", "date": "2009", "authors": "Wang Z, Park K, Comer F, Hsieh-Wilson LC, Saudek CD, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11217", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11217" } ], "reference": [ { "type": "PubMed", "id": "18984734", "url": "https://glygen.org/publication/PubMed/18984734" } ] }, { "title": "Specific functions of lysosomal proteases in endocytic and autophagic pathways.", "journal": "Biochimica et biophysica acta", "date": "2012", "authors": "Muller S, Dennemarker J, Reinheckel T", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "21767668", "url": "https://glygen.org/publication/PubMed/21767668" } ] }, { "title": "Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1.", "journal": "Cell metabolism", "date": "2012", "authors": "Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y, Zhao S, Guan KL", "evidence": [ { "database": "iPTMnet", "id": "P11217", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11217" } ], "reference": [ { "type": "PubMed", "id": "22225877", "url": "https://glygen.org/publication/PubMed/22225877" } ] }, { "title": "The family of glycogen phosphorylases: structure and function.", "journal": "Critical reviews in biochemistry and molecular biology", "date": "1989", "authors": "Newgard CB, Hwang PK, Fletterick RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "2667896", "url": 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Lornage X, Laforet P, Orngreen MC, Edelweiss E, Brochier G, Bui MT, Silva-Rojas R, Birck C, Lannes B, Romero NB, Vissing J, Laporte J, Bohm J", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" } ], "reference": [ { "type": "PubMed", "id": "32386344", "url": "https://glygen.org/publication/PubMed/32386344" } ] }, { "title": "PYGM mRNA expression in McArdle disease: Demographic, clinical, morphological and genetic features.", "journal": "PloS one", "date": "2020", "authors": "Carvalho AAS, Christofolini DM, Perez MM, Alves BCA, Rodart I, Figueiredo FWS, Turke KC, Feder D, Junior MCF, Nucci AM, Fonseca FLA", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" } ], "reference": [ { "type": "PubMed", "id": "32735634", "url": "https://glygen.org/publication/PubMed/32735634" } ] }, { "title": "Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease.", "journal": "Cells", "date": "2021", "authors": "Migocka-Patrzalek M, Elias M", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" } ], "reference": [ { "type": "PubMed", "id": "33924466", "url": "https://glygen.org/publication/PubMed/33924466" } ] }, { "title": "Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.", "journal": "Proteins", "date": "1987", "authors": "Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "3447177", "url": "https://glygen.org/publication/PubMed/3447177" } ] }, { "title": "Molecular mechanisms of McArdle's disease (muscle glycogen phosphorylase deficiency). RNA and DNA analysis.", "journal": "J. Clin. Invest.", "date": "1987", "authors": "Gautron S, Daegelen D, Mennecier F, Dubocq D, Kahn A, Dreyfus J C", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "3466902", "url": "https://glygen.org/publication/PubMed/3466902" } ] }, { "title": "Whole-exome sequencing detects PYGM variants in two adults with McArdle disease.", "journal": "Cold Spring Harbor molecular case studies", "date": "2022", "authors": "Thomas-Wilson A, Dharmadhikari AV, Heymann JJ, Jobanputra V, DiMauro S, Hirano M, Naini AB, Ganapathi M", "evidence": [ { "database": "RefSeq", "id": "NP_001158188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158188" } ], "reference": [ { "type": "PubMed", "id": "35022222", "url": "https://glygen.org/publication/PubMed/35022222" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11217", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11217" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs.", "journal": "Eur. J. Biochem.", "date": "1985", "authors": "Hwang P K, See Y P, Vincentini A M, Powers M A, Fletterick R J, Crerar M M", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "3840433", "url": "https://glygen.org/publication/PubMed/3840433" } ] }, { "title": "A kinetic study of the isozymes determined by the three human phosphoglucomutase loci PGM1, PGM2, and PGM3.", "journal": "European journal of biochemistry", "date": "1974", "authors": "Quick CB, Fisher RA, Harris H", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "4829444", "url": "https://glygen.org/publication/PubMed/4829444" } ] }, { "title": "Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease.", "journal": "Biochemistry", "date": "1970", "authors": "Brown BI, Brown DH, Jeffrey PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "5264799", "url": "https://glygen.org/publication/PubMed/5264799" } ] }, { "title": "Correlation between subunit interactions and enzymatic activity of phosphorylase a. Method for determining equilibrium constants from initial rate measurements.", "journal": "Biochemistry", "date": "1970", "authors": "Huang CY, Graves DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "5461220", "url": "https://glygen.org/publication/PubMed/5461220" } ] }, { "title": "The molecular genetic basis of myophosphorylase deficiency (McArdle's disease).", "journal": "Muscle & nerve. Supplement", "date": "1995", "authors": "Tsujino S, Shanske S, Nonaka I, DiMauro S", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "7603523", "url": "https://glygen.org/publication/PubMed/7603523" } ] }, { "title": "X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit.", "journal": "American journal of human genetics", "date": "1995", "authors": "van den Berg IE, van Beurden EA, Malingre HE, van Amstel HK, Poll-The BT, Smeitink JA, Lamers WH, Berger R", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "7847371", "url": "https://glygen.org/publication/PubMed/7847371" } ] }, { "title": "The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1993", "authors": "March RE, Putt W, Hollyoake M, Ives JH, Lovegrove JU, Hopkinson DA, Edwards YH, Whitehouse DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "7902568", "url": "https://glygen.org/publication/PubMed/7902568" } ] }, { "title": "Molecular genetic heterogeneity of myophosphorylase deficiency (McArdle's disease).", "journal": "The New England journal of medicine", "date": "1993", "authors": "Tsujino S, Shanske S, DiMauro S", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "8316268", "url": "https://glygen.org/publication/PubMed/8316268" } ] }, { "title": "Structural and functional changes of lysosomal acid alpha-glucosidase during intracellular transport and maturation.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Wisselaar HA, Kroos MA, Hermans MM, van Beeumen J, Reuser AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "8420990", "url": "https://glygen.org/publication/PubMed/8420990" } ] }, { "title": "Two novel missense mutations (E654K, L396P) in Caucasian patients with myophosphorylase deficiency (McArdle's disease).", "journal": "Human mutation", "date": "1995", "authors": "Tsujino S, Shanske S, Martinuzzi A, Heiman-Patterson T, DiMauro S", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "8535454", "url": "https://glygen.org/publication/PubMed/8535454" } ] }, { "title": "Mutations in exon 3 of the glycogen debranching enzyme gene are associated with glycogen storage disease type III that is differentially expressed in liver and muscle.", "journal": "The Journal of clinical investigation", "date": "1996", "authors": "Shen J, Bao Y, Liu HM, Lee P, Leonard JV, Chen YT", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "8755644", "url": "https://glygen.org/publication/PubMed/8755644" } ] }, { "title": "Mutations in the testis/liver isoform of the phosphorylase kinase gamma subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans.", "journal": "Nature genetics", "date": "1996", "authors": "Maichele AJ, Burwinkel B, Maire I, Sovik O, Kilimann MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "8896567", "url": "https://glygen.org/publication/PubMed/8896567" } ] }, { "title": "Mutation analysis in myophosphorylase deficiency (McArdle's disease).", "journal": "Annals of neurology", "date": "1998", "authors": "Vorgerd M, Kubisch C, Burwinkel B, Reichmann H, Mortier W, Tettenborn B, Pongratz D, Lindemuth R, Tegenthoff M, Malin JP, Kilimann MW", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "9506549", "url": "https://glygen.org/publication/PubMed/9506549" } ] }, { "title": "Molecular diagnosis of McArdle disease: revised genomic structure of the myophosphorylase gene and identification of a novel mutation.", "journal": "Hum. Mutat.", "date": "1998", "authors": "Kubisch C, Wicklein E M, Jentsch T J", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "reference": [ { "type": "PubMed", "id": "9633816", "url": "https://glygen.org/publication/PubMed/9633816" } ] }, { "title": "Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0.", "journal": "The Journal of clinical investigation", "date": "1998", "authors": "Orho M, Bosshard NU, Buist NR, Gitzelmann R, Aynsley-Green A, Blumel P, Gannon MC, Nuttall FQ, Groop LC", "evidence": [ { "database": "Reactome", "id": "R-HSA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221" } ], "reference": [ { "type": "PubMed", "id": "9691087", "url": "https://glygen.org/publication/PubMed/9691087" } ] } ], "pathway": [ { "id": "hsa:5837", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5837", "resource": "KEGG Pathway" }, { "id": "R-HSA-70221", "name": "Glycogen breakdown (glycogenolysis)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70221", "resource": "Reactome", "description": "Glycogen breakdown (glycogenolysis)" } ], "orthologs": [ { "uniprot_canonical_ac": "P09812-1", "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "Pygm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRPLSDQDKRKQISVRGLAGVENVSDLKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVDRWIRTQQHYYAKDPKRIYYLSLELYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPPYFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDKFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELIRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEEYISDLDQLRKLLSYLDDQAFIRDVAKVKQENKLKFSAYLETEYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRFRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEDNFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMVMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGLEPSRQRLPAPDEKI", "length": 842 }, "evidence": [ { "id": "45924630", "url": "http://www.informatics.jax.org/homology/45924630", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9WUB3-1", "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "Pygm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRPLSDQDKRKQISVRGLAGVENVSELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGSRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKI", "length": 842 }, "evidence": [ { "id": "45924630", "url": "http://www.informatics.jax.org/homology/45924630", "database": "MGI" }, { "id": "P11217", "url": "https://omabrowser.org/oma/group/P11217/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "glycogen phosphorylase activity", "id": "GO:0008184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008184", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "linear malto-oligosaccharide phosphorylase activity", "id": "GO:0102250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102250", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "SHG alpha-glucan phosphorylase activity", "id": "GO:0102499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102499", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glycogen metabolic process", "id": "GO:0005977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" }, { "name": "glycogen catabolic process", "id": "GO:0005980", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005980", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 482, "end_pos": 484, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.", "evidence": [ { "database": "UniProtKB", "id": "P11217", "url": "https://www.uniprot.org/uniprot/P11217" }, { "database": "PubMed", "id": "1150650", "url": "https://glygen.org/publication/PubMed/1150650" } ] } ], "interactions": [], "reactions": [ { "id": "41732", "name": "", "equation": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53534-1", "P09811-1", "P09812-1", "P11216-1", "P06737-1", "P11217-1", "Q8CI94-1", "Q9WUB3-1", "Q9ET01-1", "P06738-1", "P34114-1", "Q00766-1", "Q9XTL9-1" ], "evidence": [ { "id": "41732", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41732" } ] }, { "id": "R-HSA-453338", "name": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP", "equation": "", "summary": "Cytosolic, non-phosphorylated PGYM dimers (b form) complexed with AMP can reversibly dissociate (Rath et al. 2000).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11217-1" ], "evidence": [ { "id": "R-HSA-453338", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-453338" } ] }, { "id": "R-HSA-453342", "name": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex", "equation": "", "summary": "Cytosolic, non-phosphorylated PGYM dimers (b form) can reversibly bind AMP. This reaction is negatively regulated by ATP and glucose 6-phosphate and is the means by which high levels of these molecules repress PGYM activity (Rath et al. 2000).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11217-1" ], "evidence": [ { "id": "R-HSA-453342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-453342" } ] }, { "id": "R-HSA-453358", "name": "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]", "equation": "", "summary": "The PYGM and PYGB forms of glycogen phosphorylase catalyze the reaction of orthophosphate and poly((1,4) alpha glucosyl) glycogenin-1 to form D-glucose 1-phosphate and glycogenin-1. This reaction occurs on the surfaces of cytosolic glycogen granules. The phosphorylated forms of PYGM and PYGB dimers (a form) are catalytically active; the non-phosphorylated dimers (b form) become active when complexed with AMP. In the body, this reaction takes place in tissues other than the liver where its sensitivity to AMP allows glucose mobilization in response to acute energy needs of the individual cell, and hormonally mediated phosphorylation can stimulate increased glucose production, still for use by the individual producing cell, in response to stress signals. These reactions have not been characterized in detail but are inferred to occur from the very close similarity among PGYM, PGYB, and PGYL (Newgard et al. 1989; Rath et al. 2000).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11217-1", "P11216-1", "P46976-1" ], "evidence": [ { "id": "R-HSA-453358", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-453358" } ] }, { "id": "R-HSA-71515", "name": "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]", "equation": "", "summary": "The PYGM and PYGB forms of glycogen phosphorylase catalyze the reaction of orthophosphate and glycogen-glycogenin 1 to form D-glucose 1-phosphate and limit dextrin-glycogenin 1. This reaction occurs on the surfaces of cytosolic glycogen granules. The phosphorylated forms of PYGM and PYGB dimers (a form) are catalytically active; the non-phosphorylated dimers (b form) become active when complexed with AMP. In the body, this reaction takes place in tissues other than the liver where its sensitivity to AMP allows glucose mobilization in response to acute energy needs of the individual cell, and hormonally mediated phosphorylation can stimulate increased glucose production, still for use by the individual producing cell, in response to stress signals. These reactions have not been characterized in detail but are inferred to occur from the very close similarity among PGYM, PGYB, and PGYL (Newgard et al. 1989; Rath et al. 2000).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11217-1", "P11216-1", "P46976-1" ], "evidence": [ { "id": "R-HSA-71515", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71515" } ] }, { "id": "R-HSA-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "equation": "", "summary": "The cytosolic phosphorylase kinase complex catalyzes the phosphorylation of the subunits of the glycogen phosphorylase (PYGM) dimer. Two forms of phosphorylase kinase complex have been described (Brushia and Walsh 1999). The one annotated here, consisting of four copies each of PHKA1 (alpha regulatory) (Burwinkel et al 2003), PHKB (beta regulatory) (Burwinkel et al. 2003), PHKG1 (gamma catalytic) (Burwinkel et al. 2003) and CALM (calmodulin) subunits is abundant in muscle and its action on the form of phosphorylase (PYGM) abundant in muscle is described.

While initial studies of PGYM from rabbit muscle suggested that it is a homotetramer (Keller and Cori 1953), more recent work indicates that under physiological conditions the enzyme occurs as a homodimer (Huang and Graves 1970) and a dimeric structure for the human enzyme is inferred here.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11217-1", "Q16816-1" ], "evidence": [ { "id": "R-HSA-71541", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71541" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P06737", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P06737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06737" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P06737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06737" } ] } ] }, { "uniprot_ac": "P06738", "gene_name": "GPH1", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P06738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06738" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P06738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06738" } ] } ] }, { "uniprot_ac": "P09811", "gene_name": "Pygl", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P09811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09811" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P09811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09811" } ] } ] }, { "uniprot_ac": "P09812", "gene_name": "Pygm", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P09812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09812" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P09812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09812" } ] } ] }, { "uniprot_ac": "P11216", "gene_name": "PYGB", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P11216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11216" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P11216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11216" } ] } ] }, { "uniprot_ac": "P11217", "gene_name": "PYGM", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P11217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11217" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P11217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11217" } ] } ] }, { "uniprot_ac": "P34114", "gene_name": "glpD", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P34114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34114" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P34114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34114" } ] } ] }, { "uniprot_ac": "P46976", "gene_name": "GYG1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "P46976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46976" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "P46976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46976" } ] } ] }, { "uniprot_ac": "P53534", "gene_name": "Pygb", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P53534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53534" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P53534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53534" } ] } ] }, { "uniprot_ac": "Q00766", "gene_name": "glpV", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q00766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00766" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q00766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00766" } ] } ] }, { "uniprot_ac": "Q16816", "gene_name": "PHKG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] }, { "ec_number": "2.7.11.19", "activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] }, { "ec_number": "2.7.11.19", "activity": "", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] } ] }, { "uniprot_ac": "Q8CI94", "gene_name": "Pygb", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q8CI94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CI94" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q8CI94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CI94" } ] } ] }, { "uniprot_ac": "Q9ET01", "gene_name": "Pygl", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q9ET01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET01" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q9ET01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET01" } ] } ] }, { "uniprot_ac": "Q9WUB3", "gene_name": "Pygm", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q9WUB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUB3" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q9WUB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUB3" } ] } ] }, { "uniprot_ac": "Q9XTL9", "gene_name": "Glyp", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q9XTL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9XTL9" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q9XTL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9XTL9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 300, 735 ], "glycation_sites": [], "phosphorylation_sites": [ 15, 204, 227, 430, 473, 514, 747, 748 ], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 482, "end_pos": 484 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 47 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }