{ "uniprot_canonical_ac": "P11150-1", "uniprot_ac": "P11150", "uniprot_id": "LIPC_HUMAN", "mass": { "chemical_mass": 55914.0, "monoisotopic_mass": 55914.0 }, "refseq": { "ac": "NP_000227", "name": "hepatic triacylglycerol lipase precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" }, "gene_names": [ { "name": "LIPC", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11150", "id": "P11150" }, { "name": "HDLCQ12; HL; HTGL; LIPH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227", "id": "NP_000227" }, { "name": "HTGL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P11150", "id": "P11150" }, { "name": "LIPC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227", "id": "NP_000227" } ], "protein_names": [ { "name": "Hepatic triacylglycerol lipase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11150" }, { "name": "3.1.1.32", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "3.1.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "3.1.1.5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "HL", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "Hepatic lipase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "Lipase member C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "Lysophospholipase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "Phospholipase A1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11150" }, { "name": "hepatic triacylglycerol lipase precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227", "id": "NP_000227" }, { "name": "hepatic triacylglycerol lipase; hepatic lipase; lipase member C; lipase, hepatic; Triacylglycerol lipase; phospholipase A1; lysophospholipase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227", "id": "NP_000227" } ], "function": [ { "annotation": "Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study.", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" }, { "database": "PubMed", "id": "33673789", "url": "https://glygen.org/publication/PubMed/33673789" } ] }, { "annotation": "Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:7592706, PubMed:8798474, PubMed:12032167, PubMed:26193433). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433).", "evidence": [ { "database": "UniProtKB", "id": "P11150", "url": "https://www.uniprot.org/uniprot/P11150#function" }, { "database": "PubMed", "id": "7592706", "url": "https://glygen.org/publication/PubMed/7592706" }, { "database": "PubMed", "id": "8798474", "url": "https://glygen.org/publication/PubMed/8798474" }, { "database": "UniProtKB", "id": "P07867", "url": "https://www.uniprot.org/uniprot/P07867#function" }, { "database": "PubMed", "id": "12032167", "url": "https://glygen.org/publication/PubMed/12032167" }, { "database": "PubMed", "id": "26193433", "url": "https://glygen.org/publication/PubMed/26193433" } ] }, { "annotation": "Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" }, { "database": "PubMed", "id": "36274132", "url": "https://glygen.org/publication/PubMed/36274132" } ] }, { "annotation": "Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" }, { "database": "PubMed", "id": "33499410", "url": "https://glygen.org/publication/PubMed/33499410" } ] }, { "annotation": "Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia.", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" }, { "database": "PubMed", "id": "35899625", "url": "https://glygen.org/publication/PubMed/35899625" } ] }, { "annotation": "[Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype].", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" }, { "database": "PubMed", "id": "37460425", "url": "https://glygen.org/publication/PubMed/37460425" } ] } ], "disease": [ { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "125853", "database": "MIM", "url": "https://www.omim.org/entry/125853" } ] }, { "disease_id": "MONDO:0013533", "recommended_name": { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "hyperlipidemia due to hepatic triglyceride lipase deficiency", "description": "Hyperlipidemia due to hepatic triacylglycerol lipase deficiency is a rare, genetic hyperalphalipoproteinemia characterized by elevated plasma cholesterol and triglyceride (TG) levels with a marked TG enrichment of low- and high-density lipoproteins (HDL), presence of circulating beta-very low density lipoproteins and elevated HDL cholesterol levels, in the presence of a very low, or undetectable, postheparin plasma hepatic lipase activity. Premature atherosclerosis and/or coronary heart disease may be associated." }, "synonyms": [ { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "hyperlipidemia due to HL deficiency", "description": "" }, { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "hyperlipidemia due to HTGL deficiency", "description": "" }, { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "hyperlipidemia due to hepatic lipase deficiency", "description": "" }, { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "HL deficiency", "description": "" }, { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "hepatic lipase deficiency", "description": "" }, { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "hyperlipidemia due to hepatic triacylglycerol lipase deficiency", "description": "" }, { "id": "MONDO:0013533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013533", "name": "lipc deficiency", "description": "" }, { "id": "MIM:614025", "resource": "MIM", "url": "https://www.omim.org/entry/614025", "name": "Hepatic lipase deficiency", "description": "Hepatic lipase deficiency" } ], "evidence": [ { "id": "614025", "database": "MIM", "url": "https://www.omim.org/entry/614025" } ] } ], "snv": [ { "evidence": [ { "id": "rs746618309", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746618309" }, { "id": "rs746618309", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746618309" }, { "id": "rs746618309", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746618309#frequency_tab" }, { "id": "rs746618309", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746618309" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 399, "end_pos": 399, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TYS->NYS); n-glyco-sequon-loss (NKT->NKN).", "chr_id": "15", "chr_pos": "58563714", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T399", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs201654179", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201654179" }, { "id": "rs201654179", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201654179" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 18, "end_pos": 18, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IQS->NQS).", "chr_id": "15", "chr_pos": "58432085", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "I18", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P11150", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11150" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 307, "end_pos": 307, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (SFS->NFS).", "chr_id": "15", "chr_pos": "58548441", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S307", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is 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"https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P11150", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11150" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://www.ensembl.org/id/ENSP00000395569.3" } ] } }, { "isoform_ac": "E7EUK6-1", "url": "", "sequence": { "sequence": "MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR", "length": 438, "header": "tr|E7EUK6-1|LIPC_HUMAN Computationally mapped isoform of Hepatic triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPC PE=1 SV=1 CANONICAL=P11150-1" }, "locus": { "chromosome": "15", "start_pos": 58568824, "end_pos": 58432033, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000433326.2", "url": "https://www.ensembl.org/id/ENST00000433326.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000395002.2", "url": "https://www.ensembl.org/id/ENSP00000395002.2" } ] } }, { "isoform_ac": "P11150-1", "url": "", "sequence": { "sequence": "MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR", "length": 499, "header": "sp|P11150-1|LIPC_HUMAN Isoform 1 of Hepatic triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPC PE=1 SV=3 CANONICAL=P11150-1" }, "locus": { "chromosome": "15", "start_pos": 58568824, "end_pos": 58432033, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000299022.10", "url": "https://www.ensembl.org/id/ENST00000299022.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000299022.5", "url": "https://www.ensembl.org/id/ENSP00000299022.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 362, "start_aa": "Asn", "end_pos": 362, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn362", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 397, "start_aa": "Asn", "end_pos": 397, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn397", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 42, "start_aa": "Asn", "end_pos": 42, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn42", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 78, "start_aa": "Asn", "end_pos": 78, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn78", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of single-nucleotide polymorphisms in coding regions of human genes.", "journal": "Nat. Genet.", "date": "1999", "authors": "Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES", "evidence": [ { "database": "UniProtKB", "id": "P11150", "url": "https://www.uniprot.org/uniprot/P11150" } ], "reference": [ { "type": "PubMed", "id": "10391209", "url": "https://glygen.org/publication/PubMed/10391209" } ] }, { "title": "18 bp insertion/duplication with internal missense mutation in human hepatic lipase gene exon 3. Mutations in brief no. 181. 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Chem.", "date": "1988", "authors": "Martin G A, Busch S J, Meredith G D, Cardin A D, Blankenship D T, Mao S J, Rechtin A E, Woods C W, Racke M M, Schafer M P", "evidence": [ { "database": "UniProtKB", "id": "P11150", "url": "https://www.uniprot.org/uniprot/P11150" } ], "reference": [ { "type": "PubMed", "id": "2839510", "url": "https://glygen.org/publication/PubMed/2839510" } ] }, { "title": "Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies.", "journal": "Genes", "date": "2021", "authors": "Liao YH, Er LK, Wu S, Ko YL, Teng MS", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" } ], "reference": [ { "type": "PubMed", "id": "33499410", "url": "https://glygen.org/publication/PubMed/33499410" } ] }, { "title": "Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study.", "journal": "Nucleosides, nucleotides & nucleic acids", "date": "2021", "authors": "Seyedian SM, Bijanzadeh M, Ahmadi F, Haghighizadeh MH", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" } ], "reference": [ { "type": "PubMed", "id": "33673789", "url": "https://glygen.org/publication/PubMed/33673789" } ] }, { "title": "Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia.", "journal": "Circulation", "date": "2022", "authors": "Dijk W, Di Filippo M, Kooijman S, van Eenige R, Rimbert A, Caillaud A, Thedrez A, Arnaud L, Pronk A, Garcon D, Sotin T, Lindenbaum P, Ozcariz Garcia E, Pais de Barros JP, Duvillard L, Si-Tayeb K, Amigo N, Le Questel JY, Rensen PCN, Le May C, Moulin P, Cariou B", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" } ], "reference": [ { "type": "PubMed", "id": "35899625", "url": "https://glygen.org/publication/PubMed/35899625" } ] }, { "title": "Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis.", "journal": "Journal of translational medicine", "date": "2022-10-23", "authors": "Deng Ruxia, Lu Xiansheng, Hong Chang, Cai Rui, Wang Ping, Xiong Le, Wang Xiaoyu, Chen Qiaoyu, Lin Jie", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" } ], "reference": [ { "type": "PubMed", "id": "36274132", "url": "https://glygen.org/publication/PubMed/36274132" } ] }, { "title": "[Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype].", "journal": "Zhonghua xin xue guan bing za zhi", "date": "2023-07-24", "authors": "Zhang H, Li F Y, Hao Y, Wang X M, Zhang J, Ma Y L, Zeng H, Lin J", "evidence": [ { "database": "RefSeq", "id": "NP_000227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227" } ], "reference": [ { "type": "PubMed", "id": "37460425", "url": "https://glygen.org/publication/PubMed/37460425" } ] }, { "title": "Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Berryman DE, Bensadoun A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8963889", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8963889" } ], "reference": [ { "type": "PubMed", "id": "7592670", "url": "https://glygen.org/publication/PubMed/7592670" } ] }, { "title": "Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Dugi KA, Dichek HL, Santamarina-Fojo S", "evidence": [ { "database": "UniProtKB", "id": "P11150", "url": "https://www.uniprot.org/uniprot/P11150" } ], "reference": [ { "type": "PubMed", "id": "7592706", "url": "https://glygen.org/publication/PubMed/7592706" } ] }, { "title": "Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.", "journal": "European journal of biochemistry", "date": "1994", "authors": "Siezen RJ, Creemers JW, Van de Ven WJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-8963889", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8963889" } ], "reference": [ { "type": "PubMed", "id": "8020465", "url": "https://glygen.org/publication/PubMed/8020465" } ] }, { "title": "Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Ji ZS, Fazio S, Lee YL, Mahley RW", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964026", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964026" } ], "reference": [ { "type": "PubMed", "id": "8300609", "url": "https://glygen.org/publication/PubMed/8300609" } ] }, { "title": "Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics.", "journal": "Arteriosclerosis and thrombosis : a journal of vascular biology", "date": "1993", "authors": "Hegele RA, Little JA, Vezina C, Maguire GF, Tu L, Wolever TS, Jenkins DJ, Connelly PW", "evidence": [ { "database": "Reactome", "id": "R-HSA-8963889", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8963889" } ], "reference": [ { "type": "PubMed", "id": "8485124", "url": "https://glygen.org/publication/PubMed/8485124" } ] }, { "title": "Human hepatic lipase subunit structure determination.", "journal": "The Journal of biological chemistry", "date": "1996-09-13", "authors": "Hill J S, Davis R C, Yang D, Wen J, Philo J S, Poon P H, Phillips M L, Kempner E S, Wong H", "evidence": [ { "database": "UniProtKB", "id": "P11150", "url": "https://www.uniprot.org/uniprot/P11150" } ], "reference": [ { "type": "PubMed", "id": "8798474", "url": "https://glygen.org/publication/PubMed/8798474" } ] }, { "title": "Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene.", "journal": "Mol. Cell. Probes", "date": "1996", "authors": "Takagi A, Ikeda Y, Mori A, Ashida Y, Yamamoto A", "evidence": [ { "database": "UniProtKB", "id": "P11150", "url": "https://www.uniprot.org/uniprot/P11150" } ], "reference": [ { "type": "PubMed", "id": "8865180", "url": "https://glygen.org/publication/PubMed/8865180" } ] }, { "title": "Interaction of lipoproteins with heparan sulfate proteoglycans and with lipoprotein lipase. 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"P19835-1", "P54315-1", "Q9Y5X9-1", "P54317-1", "Q17RR3-1", "P07098-1", "P16233-1", "Q05469-1", "P06858-1", "P11150-1", "Q9NST1-1", "Q96AD5-1", "P41247-1", "Q6P1J6-1", "Q8NCG7-1", "Q7Z6Z6-1", "Q99PG0-1", "Q9QXM0-1", "Q64285-1", "P54310-1", "P27656-1", "P17892-1", "Q9WVG5-1", "Q9CPP7-1", "P11152-1", "Q6P8U6-1", "Q91WW7-1", "Q8BJ56-1", "Q91WC9-1", "Q32LZ8-1", "Q3TTY0-1", "P25641-1", "P54857-1", "P40308-1", "P40471-1", "Q12043-1", "P36165-1", "P38139-1", "Q06522-1", "P47145-1", "Q9VMM8-1" ], "evidence": [ { "id": "12044", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12044" } ] }, { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54728-1", "O88202-1", "P50393-1", "P97570-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "D3ZRC4-1", "P47712-1", "Q86U10-1", "Q6P1J6-1", "Q9NP80-1", "Q8IY17-4", "P0C869-1", "P11150-1", "O60733-1", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "A0JNU3-1", "Q8K1N1-1", "P47713-1", "Q3TRM4-1", "Q3TTY0-1", "P0C871-1", "Q8VEB4-1", "A2AJ88-1", "P97819-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q04958-1", "Q08108-1", "Q9U969-1", "Q9VMM8-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "18689", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "D3ZRC4-1", "P07867-1", "Q06000-1", "Q8VBX1-1", "Q675A5-1", "D2KX21-1", "Q4KLN5-1", "Q8WU67-1", "Q9HDD0-1", "Q9UL19-1", "Q9NWW9-1", "Q96KN8-1", "P53816-1", "P11150-1", "Q9Y5X9-1", "P06858-1", "Q8NCC3-1", "Q9NP80-1", "Q8NEL9-1", "Q91ZH7-1", "Q9CPX5-1", "Q9QZU4-1", "Q8R3U1-1", "Q8K1N1-1", "P11152-1", "Q8VEB4-1", "P27656-1", "Q9WVG5-1", "Q80YA3-1" ], "evidence": [ { "id": "18689", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18689" } ] }, { "id": "38391", "name": "", "equation": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07867-1", "P0C548-1", "P11150-1", "Q96AD5-1", "P27656-1", "Q8BJ56-1" ], "evidence": [ { "id": "38391", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38391" } ] }, { "id": "38511", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C1S9-1", "P07867-1", "Q5YLM1-1", "P11150-1", "Q9Y4D2-1", "Q8NCG7-1", "Q91WC9-1", "Q6WQJ1-1", "P27656-1" ], "evidence": [ { "id": "38511", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38511" } ] }, { "id": "38575", "name": "", "equation": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "O54728-1", "P54318-1", "P07867-1", "P15304-1", "Q06000-1", "Q8VBX1-1", "P27657-1", "P19835-1", "P16233-1", "Q6P1J6-1", "P11150-1", "Q9Y5X9-1", "P06858-1", "Q05469-1", "P54317-1", "Q6P8U6-1", "Q64285-1", "P54310-1", "P17892-1", "P11152-1", "Q3TTY0-1", "P27656-1", "Q9WVG5-1", "P54857-1", "P40308-1", "P40471-1", "P36165-1", "Q9VMM8-1" ], "evidence": [ { "id": "38575", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38575" } ] }, { "id": "38651", "name": "", "equation": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07867-1", "P11150-1", "P27656-1" ], "evidence": [ { "id": "38651", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38651" } ] }, { "id": "38699", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07867-1", "Q06000-1", "Q675A5-1", "P11150-1", "P06858-1", "Q8NCC3-1", "P11152-1", "Q8VEB4-1", "P27656-1" ], "evidence": [ { "id": "38699", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38699" } ] }, { "id": "40435", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "O88202-1", "P97570-1", "O54728-1", "P50393-1", "P70470-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "Q9QYL8-1", "D3ZRC4-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "D4A328-1", "P19835-1", "Q86U10-1", "P0C869-1", "Q6P1J6-1", "P11150-1", "Q7L5L3-2", "O95372-1", "O75608-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q3MJ16-3", "Q8IY17-4", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q64285-1", "A0JNU3-1", "Q50L43-1", "Q9WTL7-1", "P97823-1", "Q8VEB4-1", "Q8K1N1-1", "A2AJ88-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q3TRM4-1", "Q3TTY0-1", "Q99LY2-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q9VMM8-1" ], "evidence": [ { "id": "40435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40435" } ] }, { "id": "40475", "name": "", "equation": "1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P54318-1", "P07867-1", "Q06000-1", "Q8VBX1-1", "P27657-1", "P16233-1", "Q9Y5X9-1", "P06858-1", "P11150-1", "P54317-1", "Q6P8U6-1", "P17892-1", "P11152-1", "P27656-1", "Q9WVG5-1", "P54857-1" ], "evidence": [ { "id": "40475", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40475" } ] }, { "id": "40499", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYT7-1", "P97535-1", "P07867-1", "Q5BK26-1", "Q8N2K0-1", "P11150-1", "Q53H76-1", "Q6ZV29-1", "Q99LR1-1", "A2AJ88-1", "Q8VI78-1", "P27656-1" ], "evidence": [ { "id": "40499", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40499" } ] }, { "id": "41384", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P07867-1", "Q06000-1", "Q8VBX1-1", "P53816-1", "P11150-1", "Q9Y5X9-1", "P06858-1", "Q8R3U1-1", "P11152-1", "P27656-1", "Q9WVG5-1" ], "evidence": [ { "id": "41384", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41384" } ] }, { "id": "R-HSA-174657", "name": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex", "equation": "", "summary": "Chylomicron micron remnants containing apolipoprotein E associate with the surfaces of cells in a process that probably involves several steps and that requires the presence (but not the catalytic activity) of heparan sulfate proteoglycan (HSPG)-associated hepatic lipase (HL). This process ultimately results in binding of the remnant to cell-surface LDL receptors (LDLR) (Ji et al. 1994). The molecular details of LDLR binding, and of the following steps of remnant endocytosis, are inferred from those of the coorresponding step of LDLR-mediated low-density lipoprotein (LDL) endocytosis. In the body, this process occurs in the liver.", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11150-1" ], "evidence": [ { "id": "R-HSA-174657", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174657" } ] }, { "id": "R-HSA-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "equation": "", "summary": "Fatty acids (FAs) are used as energy substrates and are stored as triglycerides. Triacylglycerol (TAG) has to be cleaved by lipases to be able to move in and out of cells for usage. Hepatic triacylglycerol lipase (LIPC) is one of several enzymes that catalyses the hydrolysis of TAGs to free fatty acids (FAs) and diacylglycerol (DAG) (Hegele et al. 1993, Santamarina-Fojo et al. 2004). Defects in LIPC can cause hepatic lipase deficiency (HL deficiency; MIM:614025), a disorder characterised by premature atherosclerosis and abnormal circulating lipoproteins (Hegele et al. 1992, 1993).", "cellular_location": "extracellular region", "input_participant_list": [ "R-ALL-171126" ], "output_participant_list": [ "R-ALL-422024" ], "enzyme_list": [ "P11150-1" ], "evidence": [ { "id": "R-HSA-5694109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5694109" } ] }, { "id": "R-HSA-6785178", "name": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region", "equation": "", "summary": "Hepatic triacylglycerol lipase (LIPC, and lipoprotein lipase, LPL) are dimeric lipases (Hill et al. 1997) that hydrolyse triglycerides from circulating lipoproteins thereby playing important roles in lipoprotein remodeling and uptake. LIPC dimer (as well as LPL dimer) binds to an ER membrane protein known as lipase maturation factor 1 (LMF1) which can mediate secretion and enzymatic maturation of these lipases. Human LMF1 contain five TM segments that divide the protein into six separate domains with cytoplasmic and ER lumenal orientation thereby transporting LIPC dimer from ER lumen to the cytosol. The mechanism of LIPC dimer translocation from cytosol to secretion is unknown (Doolittle et al. 2009, Babilonia-Rosa & Neher 2014). Another family member, LMF2, may function as LMF1 based on similarity. Defects in LMF1 can cause combined lipase deficiency (CLD; MIM:246650), characterised by hypertriglyceridemia caused by ER retention of both LIPC dimer and LPL dimer (Peterfy et al. 2007).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11150-1" ], "evidence": [ { "id": "R-HSA-6785178", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785178" } ] }, { "id": "R-HSA-6785181", "name": "LMF1,2 bind LIPC dimer", "equation": "", "summary": "Hepatic triacylglycerol lipase (LIPC, and lipoprotein lipase, LPL) are dimeric lipases (Hill et al. 1997) that hydrolyse triglycerides from circulating lipoproteins thereby playing important roles in lipoprotein remodeling and uptake. LIPC dimer (as well as LPL dimer) binds to an ER membrane protein known as lipase maturation factor 1 (LMF1) which can mediate secretion and enzymatic maturation of these lipases (Doolittle et al. 2009, Babilonia-Rosa & Neher 2014). Another family member, LMF2, may function as LMF1 based on similarity. Defects in LMF1 can cause combined lipase deficiency (CLD; MIM:246650), characterised by hypertriglyceridemia caused by ER retention of both LIPC and LPL (Peterfy et al. 2007).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11150-1" ], "evidence": [ { "id": "R-HSA-6785181", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785181" } ] }, { "id": "R-HSA-6785213", "name": "LIPC dimer binds heparin", "equation": "", "summary": "The hepatic triacylglycerol lipase dimer (LIPC dimer) requires binding to heparin for stability of the homodimer (Ben-Zeev et al. 2011).", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11150-1" ], "evidence": [ { "id": "R-HSA-6785213", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785213" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-171126", "participant_name": "TAGs [extracellular region]", "crossref": [ { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-422024", "participant_name": "FAs [extracellular region]", "crossref": [ { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0JNU3", "gene_name": "Aspg", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] } ] }, { "uniprot_ac": "A2AJ88", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] } ] }, { "uniprot_ac": "D2KX21", "gene_name": "Plaat1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] } ] }, { "uniprot_ac": "D3Z9B7", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] } ] }, { "uniprot_ac": "D3ZQH6", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] } ] }, { "uniprot_ac": "D3ZRC4", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] } ] }, { "uniprot_ac": "D4A1I6", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] } ] }, { "uniprot_ac": "D4A328", "gene_name": "LOC120099997", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] } ] }, { "uniprot_ac": "F1LPY6", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O75608", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] } ] }, { "uniprot_ac": "O88202", "gene_name": "Aspg", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] } ] }, { "uniprot_ac": "O95372", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] } ] }, { "uniprot_ac": "P04634", "gene_name": "Lipf", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P04634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04634" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P04634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04634" } ] } ] }, { "uniprot_ac": "P06858", "gene_name": "LPL", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] } ] }, { "uniprot_ac": "P07098", "gene_name": "LIPF", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098" } ] } ] }, { "uniprot_ac": "P07867", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] } ] }, { "uniprot_ac": "P07882", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] } ] }, { "uniprot_ac": "P08910", "gene_name": "ABHD2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] } ] }, { "uniprot_ac": "P0C1S9", "gene_name": "Daglb", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] }, { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] } ] }, { "uniprot_ac": "P0C548", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] } ] }, { "uniprot_ac": "P0C869", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] } ] }, { "uniprot_ac": "P0C871", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] } ] }, { "uniprot_ac": "P11150", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] } ] }, { "uniprot_ac": "P11152", "gene_name": "Lpl", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] } ] }, { "uniprot_ac": "P15304", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] } ] }, { "uniprot_ac": "P16233", "gene_name": "PNLIP", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P16233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16233" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P16233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16233" } ] } ] }, { "uniprot_ac": "P17892", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] } ] }, { "uniprot_ac": "P19835", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] } ] }, { "uniprot_ac": "P22760", "gene_name": "AADAC", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P22760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22760" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P22760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22760" } ] } ] }, { "uniprot_ac": "P25641", "gene_name": "ATG15", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P25641", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25641" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P25641", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25641" } ] } ] }, { "uniprot_ac": "P27656", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] } ] }, { "uniprot_ac": "P27657", "gene_name": "Pnlip", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27657" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27657" } ] } ] }, { "uniprot_ac": "P36165", "gene_name": "TGL4", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] } ] }, { "uniprot_ac": "P38139", "gene_name": "LDH1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P38139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38139" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P38139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38139" } ] } ] }, { "uniprot_ac": "P39105", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] } ] }, { "uniprot_ac": "P40308", "gene_name": "TGL3", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P40308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40308" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P40308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40308" } ] } ] }, { "uniprot_ac": "P40471", "gene_name": "AYR1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] }, { "ec_number": "1.1.1.101", "activity": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+).", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] }, { "ec_number": "1.1.1.101", "activity": "", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] } ] }, { "uniprot_ac": "P41247", "gene_name": "PNPLA4", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] } ] }, { "uniprot_ac": "P47145", "gene_name": "LIH1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P47145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47145" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P47145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47145" } ] } ] }, { "uniprot_ac": "P47712", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] } ] }, { "uniprot_ac": "P47713", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] } ] }, { "uniprot_ac": "P50393", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] } ] }, { "uniprot_ac": "P53816", "gene_name": "PLAAT3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] } ] }, { "uniprot_ac": "P53817", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] } ] }, { "uniprot_ac": "P54310", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] } ] }, { "uniprot_ac": "P54315", "gene_name": "PNLIPRP1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54315" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54315" } ] } ] }, { "uniprot_ac": "P54316", "gene_name": "Pnliprp1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54316" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54316" } ] } ] }, { "uniprot_ac": "P54317", "gene_name": "PNLIPRP2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] } ] }, { "uniprot_ac": "P54318", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] } ] }, { "uniprot_ac": "P54857", "gene_name": "TGL2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54857" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54857" } ] } ] }, { "uniprot_ac": "P70470", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] } ] }, { "uniprot_ac": "P97535", "gene_name": "Pla1a", "activity": [ { "ec_number": "3.1.1.111", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "P97535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97535" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "P97535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97535" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "P97823", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] } ] }, { "uniprot_ac": "Q03674", "gene_name": "PLB2", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] } ] }, { "uniprot_ac": "Q04958", "gene_name": "NTE1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q04958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04958" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q04958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04958" } ] } ] }, { "uniprot_ac": "Q05469", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] } ] }, { "uniprot_ac": "Q06000", "gene_name": "Lpl", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] } ] }, { "uniprot_ac": "Q06522", "gene_name": "", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q06522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06522" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q06522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06522" } ] } ] }, { "uniprot_ac": "Q08108", "gene_name": "PLB3", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q08108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08108" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q08108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08108" } ] } ] }, { "uniprot_ac": "Q12043", "gene_name": "TGL5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q12043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12043" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q12043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12043" } ] } ] }, { "uniprot_ac": "Q17RR3", "gene_name": "PNLIPRP3", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q17RR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q17RR3" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q17RR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q17RR3" } ] } ] }, { "uniprot_ac": "Q32LZ8", "gene_name": "Pnpla5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q32LZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32LZ8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q32LZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32LZ8" } ] } ] }, { "uniprot_ac": "Q3MJ16", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q4KLN5", "gene_name": "Plaat5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] } ] }, { "uniprot_ac": "Q50L41", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] } ] }, { "uniprot_ac": "Q50L42", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] } ] }, { "uniprot_ac": "Q50L43", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] } ] }, { "uniprot_ac": "Q53H76", "gene_name": "PLA1A", "activity": [ { "ec_number": "3.1.1.111", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "Q53H76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H76" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "Q53H76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H76" } ] } ] }, { "uniprot_ac": "Q5BK26", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] } ] }, { "uniprot_ac": "Q5YLM1", "gene_name": "Dagla", "activity": [ { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q5YLM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5YLM1" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "Q5YLM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5YLM1" } ] } ] }, { "uniprot_ac": "Q64285", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] } ] }, { "uniprot_ac": "Q64GA5", "gene_name": "Pla2g4c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] } ] }, { "uniprot_ac": "Q675A5", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] } ] }, { "uniprot_ac": "Q68DD2", "gene_name": "PLA2G4F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] } ] }, { "uniprot_ac": "Q6AYT7", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] } ] }, { "uniprot_ac": "Q6P1J6", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q6P8U6", "gene_name": "Pnlip", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P8U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P8U6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P8U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P8U6" } ] } ] }, { "uniprot_ac": "Q6WQJ1", "gene_name": "Dagla", "activity": [ { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6WQJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WQJ1" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "Q6WQJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WQJ1" } ] } ] }, { "uniprot_ac": "Q6ZV29", "gene_name": "PNPLA7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] } ] }, { "uniprot_ac": "Q7L5L3", "gene_name": "GDPD3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q7L5L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7L5L3" } ] } ] }, { "uniprot_ac": "Q7Z6Z6", "gene_name": "PNPLA5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q7Z6Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q7Z6Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z6" } ] } ] }, { "uniprot_ac": "Q80YA3", "gene_name": "Ddhd1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q80YA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YA3" } ] }, { "ec_number": "3.1.1.111", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "Q80YA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YA3" } ] }, { "ec_number": "3.1.1.118", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+).", "evidence": [ { "id": "Q80YA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YA3" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "Q80YA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YA3" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q80YA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YA3" } ] } ] }, { "uniprot_ac": "Q86U10", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] } ] }, { "uniprot_ac": "Q8BJ56", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] } ] }, { "uniprot_ac": "Q8IY17", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] } ] }, { "uniprot_ac": "Q8K1N1", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] } ] }, { "uniprot_ac": "Q8N2K0", "gene_name": "ABHD12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] } ] }, { "uniprot_ac": "Q8NCC3", "gene_name": "PLA2G15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] } ] }, { "uniprot_ac": "Q8NCG7", "gene_name": "DAGLB", "activity": [ { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCG7" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "Q8NCG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCG7" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCG7" } ] } ] }, { "uniprot_ac": "Q8NEL9", "gene_name": "DDHD1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEL9" } ] }, { "ec_number": "3.1.1.111", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEL9" } ] }, { "ec_number": "3.1.1.118", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+).", "evidence": [ { "id": "Q8NEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEL9" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "Q8NEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEL9" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8NEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEL9" } ] } ] }, { "uniprot_ac": "Q8R3U1", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] } ] }, { "uniprot_ac": "Q8VBX1", "gene_name": "Lipg", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBX1" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8VBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBX1" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q8VBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBX1" } ] } ] }, { "uniprot_ac": "Q8VEB4", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] } ] }, { "uniprot_ac": "Q8VI78", "gene_name": "Pla1a", "activity": [ { "ec_number": "3.1.1.111", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VI78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VI78" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "Q8VI78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VI78" } ] } ] }, { "uniprot_ac": "Q8WU67", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] } ] }, { "uniprot_ac": "Q91WC9", "gene_name": "Daglb", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q91WC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC9" } ] }, { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q91WC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC9" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "Q91WC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC9" } ] } ] }, { "uniprot_ac": "Q91WW7", "gene_name": "Pnpla3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] } ] }, { "uniprot_ac": "Q91ZH7", "gene_name": "Abhd3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] } ] }, { "uniprot_ac": "Q96AD5", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] } ] }, { "uniprot_ac": "Q96KN8", "gene_name": "PLAAT5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] } ] }, { "uniprot_ac": "Q99LR1", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] } ] }, { "uniprot_ac": "Q99LY2", "gene_name": "Gdpd3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q99LY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LY2" } ] } ] }, { "uniprot_ac": "Q99PG0", "gene_name": "Aadac", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q99PG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PG0" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q99PG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PG0" } ] } ] }, { "uniprot_ac": "Q9CPP7", "gene_name": "Lipf", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPP7" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q9CPP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPP7" } ] } ] }, { "uniprot_ac": "Q9CPX5", "gene_name": "Plaat5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] } ] }, { "uniprot_ac": "Q9HDD0", "gene_name": "PLAAT1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] } ] }, { "uniprot_ac": "Q9NP80", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] } ] }, { "uniprot_ac": "Q9NST1", "gene_name": "PNPLA3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] } ] }, { "uniprot_ac": "Q9NWW9", "gene_name": "PLAAT2", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] } ] }, { "uniprot_ac": "Q9QXM0", "gene_name": "Abhd2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q9QXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXM0" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "Q9QXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXM0" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q9QXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXM0" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q9QXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXM0" } ] } ] }, { "uniprot_ac": "Q9QYL8", "gene_name": "Lypla2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] } ] }, { "uniprot_ac": "Q9QZH8", "gene_name": "Aadac", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZH8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q9QZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZH8" } ] } ] }, { "uniprot_ac": "Q9QZU4", "gene_name": "Plaat1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] } ] }, { "uniprot_ac": "Q9U969", "gene_name": "sws", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9U969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9U969" } ] } ] }, { "uniprot_ac": "Q9UL19", "gene_name": "PLAAT4", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] } ] }, { "uniprot_ac": "Q9UP65", "gene_name": "PLA2G4C", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] } ] }, { "uniprot_ac": "Q9VMM8", "gene_name": "Dmel\\CG11029", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.3", "activity": "a 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+ S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q9WTL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTL7" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9WTL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTL7" } ] } ] }, { "uniprot_ac": "Q9WVG5", "gene_name": "Lipg", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9WVG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVG5" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9WVG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVG5" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q9WVG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVG5" } ] } ] }, { "uniprot_ac": "Q9Y4D2", "gene_name": "DAGLA", "activity": [ { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9Y4D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4D2" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "Q9Y4D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4D2" } ] } ] }, { "uniprot_ac": "Q9Y5X9", "gene_name": "LIPG", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9Y5X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y5X9" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9Y5X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y5X9" } ] }, { 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