The HSP70 family of chaperone proteins is one of the most conserved protein families in evolution (Takayama S et al. 1999; Boorstein WR et al. 1994; Brocchieri L et al. 2008). The sequence alignment of eukaryotic and bacterial HSP70 proteins revealed that the human HSP70 SBD is highly homologous to the DnaK SBD (51% sequence identity in the full-length protein and 47% identity in the SBD) (Zhang P et al. 2014). Moreover, the crystal structure of the substrate-bound human HSP70-SBD resembled the overall fold of the corresponding domain in the substrate-bound DnaK structures, confirming a similar overall architecture of the orthologous bacterial and human HSP70 proteins (Zhang P et al. 2014). Structures of nucleotide-binding domains of four human HSP70 isoforms: HSPA1L, HSPA2, HSPA6 and HSPA5 also support the view that the NBDs of human HSP70 function by conserved mechanisms (Wisniewska M et al. 2014). Structural analysis of a functionally intact bovine Hsp70 family member Hsc70 together with analysis of mutants in the interdomain linker and interface support the allosteric mechanism of the mammalian HSP70 chaperones (Wilbanks SM & McKay DB 1998; Jiang J et al. 2005).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1" ], "evidence": [ { "id": "R-HSA-3371422", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371422" } ] }, { "id": "R-HSA-3371467", "name": "SIRT1 deacetylates HSF1", "equation": "", "summary": "Sirtuin 1 (SIRT1) functions as a NAD(+)-dependent deacetylase, which regulates the heat shock response through deacetylation of HSF1 at Lys80. The acetylation at Lys80, which is located within DNA binding domain of HSF1 disrupts HSF1 DNA-binding ability. SIRT1-mediated stress-inducible regulation of HSF1 results in prolonged HSF1 binding to the heat shock promoter of hsp70 gene. The mechanism of the enzymatic reaction which couples NAD(+) hydrolysis with lysine deacetylation in the presence of acetylated peptide is described by several groups (Landry J et al. 2000; Sauve AA et al. 2001)", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q96EB6-1", "P11142-1" ], "evidence": [ { "id": "R-HSA-3371467", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371467" } ] }, { "id": "R-HSA-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "equation": "", "summary": "Stress-induced phosphoprotein 1 (STIP1, also known as HSP70-HSP90-organizing protein or HOP) functions as a mediator of interaction between heat shock protein (HSP)70 and HSP90 as part of the cellular assembly machine. It also modulates the ATPase activity of both HSP70 and HSP90, thus facilitating client protein transfer between the two. STIP1 is a monomeric protein composed of three tetratricopeptide repeat domains (TPR1, TPR2A, TPR2B) involved in protein-protein interactions, and two small aspartic acid\u2013proline repeat domains (DP1, DP2) involved in client activation (Scheufler C et al. 2000; Nelson GM et al. 2003; Yi F et al. 2010; Schmid AB et al. 2012). A flexible linker of STIP1 (HOP) connects TPR1-DP1 and TPR2A-TPR2B-DP2 modules arranging it as TPR1-DP1-TPR2A-TPR2B-DP2 (Scheufler C et al. 2000). Biochemical and crystallographic analysis revealed that TPR domains of STIP1 interact specifically with C-terminal MEEVD motifs of HSP70 or HSP90 chaperones; TPR2A binds preferentially to HSP90, whereas TPR1 and TPR2B bind to HSP70 (Scheufler C et al. 2000; Carrigan PE et al. 2006; Schmid AB et al. 2012). Furthermore, cryoelectron microscopy (cryo-EM) reconstruction of the human HSP90:STIP1 complex revealed that STIP1 may also form interactions in several other parts of HSP90, pre-organizing N-terminal domains (NTDs) of HSP90 and thus increasing accessibility of the nucleotide-binding pocket (Southworth DR & Agard DA 2011). STIP1 stabilizes an alternate HSP90 open state where hydrophobic client-binding surfaces of HSP90 monomers have converged remaining accessible for client loading (Southworth DR & Agard DA 2011). STIP1 is positioned with a TPR1 domain extending from the HSP90 dimer cleft remaining available for an interaction with HSP70. In the STIP1-stabilized HSP90 conformation the N-terminal domains have rotated to match the closed ATP conformation. However, the arrangement of the STIP1 domains in the complex seems to prevent the NTDs dimerization of HSP90 monomers and total closure of the HSP90 dimer that is required for an efficient HSP90-mediated ATP hydrolysis (Southworth DR & Agard DA 2011; Alvira S et al. 2014). HSP70, in the ADP state, readily binds HSP90:STIP1, forming a client-loading complex HSP90:STIP1:HSP70:client protein (Hern\u00e1ndez MP et al. 2002). Structural studies of GR-LBD (the ligand-binding domain of the glucocorticoid receptor) bound to HSP90:STIP1:HSP70 complex showed that one STIP1 molecule binds to the HSP90 dimer and through domain rearrangement, gives rise to two main conformations, an extended structure that recognizes and interacts with HSP70, and a compact one in which HSP70 is in contact with one HSP90 monomer (Alvira S et al. 2014). Movement between these two modes is thought to deliver the HSP70-bound substrate to the side of the HSP90 dimer opposite the site of STIP1 binding (Alvira S et al. 2014). Following client delivery by HSP70 and STIP1 release, HSP90:ATP converts to the closed ATP hydrolysis-active state to complete the chaperone cycling.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1", "P07900-1" ], "evidence": [ { "id": "R-HSA-3371503", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371503" } ] }, { "id": "R-HSA-3371518", "name": "SIRT1 binds to HSF1", "equation": "", "summary": "Surtuin 1 (SIRT1) has been shown to bind HSF1 and to function as a regulator of HSF1 DNA binding activity by controling the acetylation status of HSF1 (Westerheide SD et al 2009). SIRT1 mediates NAD(+)-dependent protein deacetylation.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q96EB6-1", "P11142-1" ], "evidence": [ { "id": "R-HSA-3371518", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371518" } ] }, { "id": "R-HSA-3371554", "name": "HSF1 acetylation at Lys80", "equation": "", "summary": "Acetylated HSF1 was detected in lysates of human embryonic kidney 293T cells which were transfected with vectors encoding a Flag-HSF1 fusion and p300 proteins and exposed to various stress conditions (Westerheide SD et al. 2012). No acetylation was found in lysates of unstressed cells. Acetylation of HSF1 may occurs on multiple lysines, such as Lys80 within the DNA binding domain. Mutation of Lys80 disrupted the DNA-binding ability of recombinant HSF1, indicating that the acetylation at Lys80 caused the regulated release of the HSF1 trimers from DNA and thus represents a regulatory step in the attenuation of the heat shock responce (Westerheide SD et al. 2009; Herbomel G et al 2013).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1", "Q09472-1", "Q92793-1" ], "evidence": [ { "id": "R-HSA-3371554", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371554" } ] }, { "id": "R-HSA-3371590", "name": "HSP70 binds to HSP40:nascent protein", "equation": "", "summary": "The human HSP70 family comprises at least eight unique gene products that differ from each other by amino acid sequence, expression level and sub-cellular localization (Daugaard M et al. 2007). HSP70 family members display highly conserved amino acid sequences and domain structures consisting of: the ATPase N-terminal domain that binds and hydrolyzes ATP (NBD), the substrate domain (SBD) that binds to exposed hydrophobic segments of client polypeptides and promote their solubility and/or folding in a dynamic ATP-dependent manner, and the C-domain that provides a \u201clid\u201d for the substrate domain (Zhang P et al. 2014; Brocchieri L et al. 2008; Wisniewska M et al. 2010). The conserved domain structure consolidates the chaperone function of the Hsp70 proteins and enables them to bind and release extended stretches of hydrophobic amino acids, exposed by incorrectly folded globular proteins in an ATP-dependent manner (Takayama S et al. 1999; Mayer MP 2013; Daugaard M et al. 2007). The initial binding of an unfolded client protein by a heat shock protein 40 (HSP40) prevents its aggregation and 'delivers' it to HSP70. The substrate binding ability of HSP70 is dependent on its bound state to either ATP or ADP (Kityk R et al. 2012; Qi R et al. 2013). Client substrates enter the HSP70 functional cycle by binding the ATP form of the chaperone, which has lower substrate affinity but faster binding and release rates compared with the ADP state. Interaction of the client in the cleft results in conformational changes in NBD that modestly increase ATP hydrolysis. Second, a transient interaction of HSP70 with J-protein co-chaperone HSP40, which has a higher affinity to ATP-bound HSP70 than ADP-bound HSP70, also stimulates the ATPase activity of HSP70 (Wittung-Stafshede P et al. 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1" ], "evidence": [ { "id": "R-HSA-3371590", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3371590" } ] }, { "id": "R-HSA-421836", "name": "trans-Golgi Network Derived Vesicle Uncoating", "equation": "", "summary": "The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the Golgi-associated vesicle membrane.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51148-1", "O00443-1", "P11142-1", "O14976-1", "Q01968-1", "O75976-1", "O75061-1" ], "evidence": [ { "id": "R-HSA-421836", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-421836" } ] }, { "id": "R-HSA-432688", "name": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating", "equation": "", "summary": "The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the lysosome membrane.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-HSA-167717", "R-HSA-264470" ], "enzyme_list": [ "Q9UBR2-1", "P15586-1", "P11142-1", "Q8NBS9-1", "O00115-1", "O75061-1" ], "evidence": [ { "id": "R-HSA-432688", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-432688" } ] }, { "id": "R-HSA-445087", "name": "CHL1 interacts with HSP7C", "equation": "", "summary": "CHL1 accumulates in the presynaptic plasma membrane and it recruits heat shock cognate 71 kDa protein (HSP7C/HSC70), in an ADP dependent manner. HSC70 interacts with the intracellular domain of CHL1. Upon synapse activation, CHL1 along with HSC70 is endocytosed and is targeted to synaptic vesicles (SVs). In synapses, HSC70 regulates uncoating of synaptic vesicles (SVs) in the clathrin-dependent recycling pathway (Leshchyns'ka et al. 2006, Zinsmaier & Bronk 2001).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1" ], "evidence": [ { "id": "R-HSA-445087", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-445087" } ] }, { "id": "R-HSA-450551", "name": "AUF1 binds translation and heat shock proteins", "equation": "", "summary": "Tetrameric AUF1 bound to RNA forms a complex with other proteins, including elongation factor eIF4G, polyA-binding protein PABP, Hsp, Hsc70, and Hsp27. AUF1 also directly interacts with polyadenylate.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1" ], "evidence": [ { "id": "R-HSA-450551", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-450551" } ] }, { "id": "R-HSA-450580", "name": "AUF1 (hnRNP D0) is ubiquitinylated", "equation": "", "summary": "AUF1 is ubiquitinated at unknown sites. The number of ubiquitin molecules conjugated to AUF1 and their linkage is unknown. Ubiquitination is required for subsequent degradation of both AUF1 and the mRNA bound by AUF1. It is uncertain if AUF1 is in a larger complex when it is ubiquitinated.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11142-1" ], "evidence": [ { "id": "R-HSA-450580", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-450580" } ] }, { "id": "R-HSA-5082356", "name": "HSF1-mediated gene expression", "equation": "", "summary": "Combination of chromatin immunoprecipitation (ChIP) microarray analysis and time course gene expression microarray analysis with and without siRNA-mediated inhibition of HSF1 showed that human HSF1 can induce the expression of different sets of target genes to maintain a wide range of biological processes (e.g., anti-apoptosis, RNA splicing, ubiquitination)(Page TG et al. 2006; Vihervaara A. et al. 2013). However, HSF1 is best known for rapid stress-induced upregulation of certain genes related to protein folding, such as HSPA1A/HSP70, HSPC/HSP90, HSPB1/HSP27, and DNAJB1/HSP40 (Mosser DD et al. 1988; Trinklein ND et al. 2004a,b; Page TG et al. 2006; Vihervaara A. et al. 2013).
In the nucleus acetylation of Histone H3 is linked to the function of the Elongator complex in transcription (Kim JH et al. 2002). Elongator complex protein 3 (ELP3), a catalytic acetyltransferase subunit of the Elongator complex, has been reported to regulate the transcription of HSP70 gene, and the histone acetyltransferase (HAT) domain of ELP3 is essential for this function (Han Q et al. 2007; Li F et al. 2001). ;",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1"
],
"evidence": [
{
"id": "R-HSA-5082356",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5082356"
}
]
},
{
"id": "R-HSA-5082369",
"name": "Acetylated HSF1 dissociates from DNA",
"equation": "",
"summary": "Inducible acetylation of HSF1 at Lys80 within the DNA binding domain results in the disrupted DNA-binding ability thus causing the regulated release of the HSF1 trimers from DNA (Westerheide SD et al. 2009). This acetylation is reversible. Activation of the deacetylase and longevity factor SIRT1 was shown to prolong HSF1 binding to the heat shock promoter of hsp70 gene by maintaining HSF1 in a deacetylated state (Westerheide SD et al. 2009). Thus, the balance between deacetylase activity of SIRT1 and acetyltransferase activity of p300 determine the DNA-binding competent state of HSF1.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-5082369",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5082369"
}
]
},
{
"id": "R-HSA-5082384",
"name": "HSP70:DNAJB1 binds HSF1",
"equation": "",
"summary": "During attenuation and recovery from heat shock, increased levels of HSP70 and HDJ1 (HSP40) were found to associate with the HSF1 activation domain, repressing its transcriptional activity (Shi Y et al. 1998)",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-5082384",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5082384"
}
]
},
{
"id": "R-HSA-5251942",
"name": "Hikeshi binds HSP70s:ATP",
"equation": "",
"summary": "Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. C11orf73 binds HSP70s in the cytosol, ready for nuclear import (Kose et al. 2012).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5251942",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5251942"
}
]
},
{
"id": "R-HSA-5251955",
"name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm",
"equation": "",
"summary": "Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. It is only able to bind HSP70s when they are bound to ATP. DnaJ homolog subfamily members (aka heat-shock 40 proteins, HSP40s) also translocate to the nucleus under heat-shock stress (Hattori et al. 1992) and can act as stimulators of intrinsic ATPase activity of HSP70s. The result is that Hikeshi dissociates from HSP70:ADP.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [
"R-HSA-5252048"
],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5251955",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5251955"
}
]
},
{
"id": "R-HSA-5251959",
"name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol",
"equation": "",
"summary": "Heat-shock 70kDa proteins (HSP70s) are a family of conserved, ubiquitously expressed heat-shock proteins which play important roles in protein folding and in protecting cells from stress. They possess three functional domains; an N-terminal ATPase domain, a substrate binding domain and a C-terminal domain. HSP70s are bound to either ATP or ADP. In the ATP-bound state, HSP70s do not interact with a substrate peptide as the C-terminal domain (which acts as a lid) is \\open\\, allowing peptides to bind to the substrate binding domain but then be released very rapidily. However, a substrate peptide in the binding domain can stimulate the intrinsic ATPase activity of HSP70s, hydrolysing ATP to ADP. With ADP bound, the C-terminal domain of HSP70s closes around the peptide, effectively trapping the peptide.
Intrinsic ATPase activity proceeds relatively slowly but can be dramatically increased by binding of J-domain chaperones such as HSP40s. These are eukaryotic orthologues of the DnaJ cochaperones found in prokaryotes. The human HSP40s that are able to modulate intrinsic ATPase activity of HSP70s are DNAJB1, B6, C2 and C7 (Raabe & Manley 1991, Melville et al. 1999, Hanai & Mashima 2003, Izawa et al. 2000, Hundley et al. 2005, Brychzy et al. 2003). They are also able to co-localise to the nucleus with HSP70s upon heat-shock (Hattori et al. 1992).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5251959",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5251959"
}
]
},
{
"id": "R-HSA-5252041",
"name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm",
"equation": "",
"summary": "Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. C11orf73-bound HSP70s bind to the nuclear pore complex (NPC) which transports the complex from the cytosol to the nucleoplasm where HSP70s can counteract heat shock-induced damage (Kose et al. 2012). NPC does not transport ADP-bound HSP70s.",
"cellular_location": "cytosol, nuclear envelope, nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1",
"P49792-1"
],
"evidence": [
{
"id": "R-HSA-5252041",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5252041"
}
]
},
{
"id": "R-HSA-5252079",
"name": "HSP110s exchange ATP for ADP on HSP70s:ADP",
"equation": "",
"summary": "The substrate binding ability of heat-shock 70kDa proteins (HSP70s) is dependant on their bound state to either ATP or ADP. Release of a protein substrate is induced when HSP70s are bound to ATP and conversely, proteins substrates bind when HSP70s are bound to ADP. Intrinsic ATPase of HSP70s slowly hydrolyses ATP to ADP. This process can be speeded up by cochaperones such as HSP40s which stimulate ATPase activity. Nucleotide exchange factors (NEFs) regulate the lifespan of the HSP70:ADP:substrate complex by exchanging ADP for ATP, thus inducing the release of the substrate. Eukaryote NEFs include heat-shock protein 105kDa (HSPH1 aka HSP110) (Schuermann et al. 2008) and the BAG family molecular chaperone regulator (BAG) family (BAG1-5). BAGs inhibit the chaperone activity of HSP70s by promoting substrate release (Takayama et al. 1997, Takayama et al. 1999). HSC70-interacting protein (ST13 aka HIP) is a 48kDa tetrameric protein able to bind the ATPase domain of HSP70s and thought to stabilise the ADP state of HSP70s (Hohfeld et al. 1995, Prapapanich et al. 1996).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5252079",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5252079"
}
]
},
{
"id": "R-HSA-5618085",
"name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein",
"equation": "",
"summary": "FKBP52 (also known as the large immunophilin FKBP4) is a co-chaperone containing tetratricopeptide repeat (TPR) domain, which binds the C-terminal sequence motif (MEEVD) of HSP90 (Wu B et al. 2004; Davies and Sanchez 2005). The stoichiometry of FKBP in receptor heterocomplexes was determined on the basis of the size of cross-linked complexes, a ratio of one molecule of receptor and two molecules of HSP90 to one molecule of FKBP52 was obtained for human PR , ER and mouse GR (Rexin M et al. 1992; Rehberger P et al. 1992; Segnitz B and Gehring U 1995). Mass spectrometry analysis showed that FKBP51 (FKBP5) and FKBP52 (FKBP4) form analogous complexes with GR:HSP90:STIP1:HSP70:ATP (Ebong IO et al. 2016). Binding of FKBP52 (FKBP4) and other immunophilins may weaken the association of TPR domain containing protein STIP1 with HSP90 complex (Li et al. 2011).
FKBP52 (FKBP4) is a member of the immunophilin (IMM) protein family of intracellular proteins that are able to bind immunosuppressant drugs, from which the term immunophilin derives (Pratt and Toft 1997; Kang et al. 2008). These proteins are also known as peptidyl-prolyl cis/trans isomerases (PPIases) for their ability to convert proline bonds from cis to trans form, a rate-limiting step in protein folding (Harding et al. 1989; Standaert et al. 1990; Galat 2003; Davies and Sanchez 2005). In addition to the PPIase and TPR domains, there are two additional domains - the nucleotide-binding domain (also called FKBD2 in FKBP proteins) where ATP binds and the calmodulin-binding domain, a poorly characterized domain able to interact with calmodulin.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q02790-1"
],
"evidence": [
{
"id": "R-HSA-5618085",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5618085"
}
]
},
{
"id": "R-HSA-5618098",
"name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein",
"equation": "",
"summary": "Immunophilin p23 (also known as PTGES3) binds selectively to the ATP-bound state of HSP90. p23 stabilizes the closed state of HSP90, which weakens the binding of STIP1(HOP) and promotes its exit from the complex (McLaughlin H et al. 2006; Karag\u00f6z GE et al. 2011). When FKBP51 (FKBP5) is present, a stable intermediate FKBP51:GR:HSP90:p23 is formed by expulsion of HSP70 and STIP1(HOP) (Ebong I et al. 2016).",
"cellular_location": "cytosol",
"input_participant_list": [
"R-HSA-265269"
],
"output_participant_list": [
"R-HSA-443857"
],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q15185-1",
"Q13451-1"
],
"evidence": [
{
"id": "R-HSA-5618098",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5618098"
}
]
},
{
"id": "R-HSA-5618105",
"name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein",
"equation": "",
"summary": "FK506 binding protein 5 (FKBP51, also known as FKBP5) is a member of the immunophilin (IMM) protein family of intracellular proteins. The signature domain of the IMM family is the peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, which is in turn the drug binding domain. IMMs are classified by their ability to bind immunosuppressant drugs \u2013 CyPs (cyclophilins) bind cyclosporine A (CsA), and FKBPs (FK506-binding pro-teins) bind FK506 (Pratt and Toft 1997; Kang et al. 2008). In addition to the PPIase domain, there are three additional domains \u2013 the nucleotide-binding domain, (also called FKBD2 in FKBP proteins) where ATP binds, the calmodulin-binding domain, a poorly characterized domain able to interact with calmodulin, and tetratricopeptide repeat (TPR) domains, sequences of 34 amino acids repeated in tandem through which FKBPs bind to the HSP90 C-terminal sequence MEEVD (Davies et al. 2005; Wu et al. 2004). Mass spectrometry analysis showed that FKBP51 (FKBP5) and FKBP52 (FKBP4) form analogous complexes with GR:HSP90:STIP1:HSP70:ATP (Ebong IO et al. 2016). Binding of FKBP51 (FKBP5) and other immunophilins may weaken the association of TPR domain containing protein STIP1 with HSP90 complex (Li et al. 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q13451-1"
],
"evidence": [
{
"id": "R-HSA-5618105",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5618105"
}
]
},
{
"id": "R-HSA-5618107",
"name": "ATP binding to HSP90 triggers conformation change",
"equation": "",
"summary": "The molecular chaperone heat-shock protein 90 (HSP90) functions as a homodimer. Each HSP90 protomer contains three flexibly linked regions, the N-terminal ATP-binding domain (NTD), the middle domain, and the C-terminal dimerization domain (Prodromou C et al. 1997; Pearl LH and Prodromou C 2006). HSP90 dimer is rather a dynamic molecule and ATP binding and hydrolysis are associated with conformational changes (Obermann WM et al. 1998; Krukenberg KA et al. 2011; Li J & Buchner J 2013; Prodromou C 2012). The structures of the isolated yeast and human N-terminal domain (NTD) of HSP90 bound to ATP, ADP and adenylylimidodiphosphate (AMP-PNP, a non-hydrolysable analogue of ATP) suggest that nucleotides bind deep in the cleft of NTD in open apo state of HSP90 (Prodromou C et al.1997; Meyer P et al. 2003, 2004; Colombo G et al. 2008; Li J et al. 2012). The structural studies of NTD of human HSP90 with antitumor agent geldanamycin (that acts as an ADP/ATP mimetic) support the polar interactions in the binding pocket described for yeast Hsp90 and ADP or ATP (Stebbins CE et al. 1997; Prodromou C et al.1997; Grenert JP et al. 1997). Once ATP is bound it helps to stabilize the closed ATP lid state, in which the gamma-phosphate of ATP provides a hydrogen bonding that promotes a stable association of the ATP lid with NTD. The association of ATP or AMP-PNP with NTD then stimulates structural changes in NTD. NMR analysis of human full-length HSP90 protein with and without ATP confirmed that ATP binding led to conformational changes in NTD (Karag\u00f6z GE et al. 2010). No structural changes were observed in the middle and C-terminal domains (Karag\u00f6z GE et al. 2010). However, other studies suggest that ATP-dependent conformational changes occur both in NTD and in the middle domain of HSP90 (Ali MM et al. 2006; Prodromou C et al. 2000; Chadli A et al. 2000; Meyer P et al. 2003). The changes are likely to involve movements of the ATP lid segment within each N-terminal domain that locates over the bound ATP (Ali MM et al. 2006; Prodromou C et al. 2000; Chadli A et al. 2000). The movement of the lids exposes surface residues that are subsequently involved in transient dimerization of the N-terminal domains of HSP90 (Ali MM et al. 2006; Prodromou C et al. 2000; Chadli A et al. 2000). The subsequent conformational changes upon ATP binding are regulated by co-chaperone activities. For example, arrangement of the STIP1 domains in the complex seems to prevent the NTDs dimerization of HSP90 monomers and total closure of the HSP90 dimer that is required for an efficient HSP90-mediated ATP hydrolysis (Southworth DR & Agard DA 2011; Alvira S et al. 2014). Thus, ATP binding coupled to co-chaperone-mediated loading of client protein to HSP90 complex regulates ATPase activity of HSP90.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1"
],
"evidence": [
{
"id": "R-HSA-5618107",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5618107"
}
]
},
{
"id": "R-HSA-5618110",
"name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein",
"equation": "",
"summary": "Immunophilin p23 (also known as PTGES3) binds selectively to the ATP-bound state of HSP90. p23 stabilizes the closed state of HSP90, which weakens the binding of STIP1(HOP) and promotes its exit from the complex (McLaughlin H et al. 2006; Karag\u00f6z GE et al. 2011). When p23 is added to the client-transfer complex in the absence of the immunophilin or with FKBP51 (FKBP5), two copies of p23 are incorporated with concomitant loss of HSP70 and HOP (Ebong I et al. 2016). By contrast no stable complex with two p23 subunits is observed in the presence of FKBP52 (FKBP4); expulsion of HSP70, HOP and p23 occur with a low population of a complex incorporating only one p23 subunit (Ebong I et al. 2016).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q02790-1",
"Q15185-1"
],
"evidence": [
{
"id": "R-HSA-5618110",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5618110"
}
]
},
{
"id": "R-HSA-6797269",
"name": "Expression of HSPA8, ALOX15",
"equation": "",
"summary": "In human peripheral blood monocytes Interleukin-4 (IL4) and IL13 significantly upregulate the levels of proteins involved in inflammatory resolution including the cytoplasmic proteins 15-lipoxygenase (ALOX15) and heat shock protein 8 (HSP8) (Chaitidis et al. 2005, Yakubenko et al. 2011).",
"cellular_location": "cytosol, nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P16050-1"
],
"evidence": [
{
"id": "R-HSA-6797269",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6797269"
}
]
},
{
"id": "R-HSA-6798748",
"name": "Exocytosis of secretory granule lumen proteins",
"equation": "",
"summary": "Secretory vesicles provide a reservoir of secreted proteins and membrane-associated receptors that are required at the earliest stages of the neutrophil-mediated inflammatory response. They are mobilized in response to a wide variety of inflammatory stimuli (Sengelov et al. 1993a,b). Resultant cell surface changes allow the neutrophil to establish firm contact with activated vascular epithelium (Faurschou & Borregaard 2003).",
"cellular_location": "extracellular region, secretory granule lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P18669-1",
"Q13464-1",
"P32320-1",
"P09917-1",
"O00487-1",
"P13639-1",
"P12268-1",
"P62937-1",
"Q96G03-1",
"P68402-1",
"Q99436-1",
"P55072-1",
"P68104-1",
"P11142-1",
"Q9Y315-1",
"P13010-1",
"P04075-1",
"P09972-1",
"P07900-1",
"P09769-1",
"P09211-1",
"Q16539-1",
"P14618-1",
"P07741-1",
"Q01432-1",
"P12956-1",
"Q7Z6Z7-1",
"Q9UNP9-1",
"P14174-1",
"P04040-1",
"O00571-1",
"P06744-1",
"P52790-1",
"P11678-1",
"P00491-1",
"P06737-1",
"P00746-1",
"Q13162-1",
"P17858-1",
"P46976-1",
"P22392-1",
"P13716-1",
"O75874-1",
"P20839-1",
"O00764-1"
],
"evidence": [
{
"id": "R-HSA-6798748",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798748"
}
]
},
{
"id": "R-HSA-6800434",
"name": "Exocytosis of ficolin-rich granule lumen proteins",
"equation": "",
"summary": "Ficoli-1 rich granules are a relatively new fourth neutrophil granule population that is enriched in the microbial lectin ficolin-1. Ficolin-1 is present in tertiary granules, but ficolin-1 rich granules can be differentiated by having low levels of gelatinases and an elevated exocytosis propensity (Rorvig et al. 2009, 2013). The importance of these granules may be to provide rapid release of pattern recognition molecules to activate the lectin complement pathway (Rorvig et al. 2009).",
"cellular_location": "extracellular region, ficolin-1-rich granule lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9UBR2-1",
"P18669-1",
"P32320-1",
"P09917-1",
"O00487-1",
"P13639-1",
"P12268-1",
"P62937-1",
"P15586-1",
"Q96G03-1",
"Q9P0J7-1",
"P68402-1",
"P36871-1",
"Q99436-1",
"P07339-1",
"P13798-1",
"P53396-1",
"P55072-1",
"P68104-1",
"P11142-1",
"Q9Y315-1",
"P04075-1",
"P09972-1",
"P07900-1",
"P09211-1",
"Q16539-1",
"P07858-1",
"P14618-1",
"P28482-1",
"Q01432-1",
"P12956-1",
"Q7Z6Z7-1",
"Q9UNP9-1",
"Q13510-1",
"P14174-1",
"P15848-1",
"P16278-1",
"Q8WVQ1-1",
"P04040-1",
"O00571-1",
"P14780-1",
"P06744-1",
"P52790-1",
"P00491-1",
"P06737-1",
"Q16769-1",
"P08236-1",
"P02794-1",
"P07384-1",
"Q14004-1",
"P00746-1",
"P98066-1",
"P25774-1",
"Q13162-1",
"P17858-1",
"P46976-1",
"P09960-1",
"P22392-1",
"P13716-1",
"O75874-1",
"P20839-1"
],
"evidence": [
{
"id": "R-HSA-6800434",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6800434"
}
]
},
{
"id": "R-HSA-8868658",
"name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating",
"equation": "",
"summary": "HSPA8 hydrolyzes ATP to promote dissociation of the clathrin coat from the vesicle (reviewed in Sousa and Lafer, 2015). Interaction of HSPA8 with the C-terminal tail of clathrin may sterically block re-stabilization of the clathrin coat, which is thought to undergo transient cycles of 'breathing', or loosening of the interactions between the triskelions (Barouch et al, 1997; Rapoport et al, 2008; Xing et al, 2010). Alternately, HSPA8 may destabilize the clathrin coat through intermolecular collisions with the coat (reveiwed in Sousa and Lafer, 2015). The HSPA8-clathrin interaction persists once clathrin has been removed from the vesicle. This is thought to preclude aberrant repolymerization of clathrin by sequestering free clathrin (Schlossman et al, 1984; reviewed in Sousa and Lafer, 2015).",
"cellular_location": "clathrin-coated endocytic vesicle membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q05193-1",
"Q9UQ16-1",
"P00533-1",
"P22681-1",
"P60709-1",
"Q2M2I8-1",
"P11142-1",
"P50570-1",
"P63261-1",
"O14976-1",
"Q01968-1",
"O15056-1",
"P13569-1",
"O75061-1",
"O43426-1"
],
"evidence": [
{
"id": "R-HSA-8868658",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8868658"
}
]
},
{
"id": "R-HSA-8868660",
"name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle",
"equation": "",
"summary": "HSPA8 (also known as HSC70) is recruited to the clathrin-coated vesicle through interaction with DNA J proteins GAK and DNAJC6 (Rapoport et al, 2008; Xing et al, 2010; reviewed in Sousa and Lafer, 2015). Recent studies examining the stoichiometry of uncoating predict between one and three HSPA8 molecules are required per clathrin triskelion for maximal uncoating in vitro (Bocking et al, 2011; Rothnie et al, 2011). After ATP hydrolysis, HSPA8 remains associated with the liberated clathrin, which prevents aberrant repolymerization and association of clathrin (Schlossman et al, 1984; reviewed in Sousa and Lafer, 2015).",
"cellular_location": "clathrin-coated endocytic vesicle membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q05193-1",
"Q9UQ16-1",
"P00533-1",
"P22681-1",
"P60709-1",
"Q2M2I8-1",
"P11142-1",
"P50570-1",
"P63261-1",
"O14976-1",
"Q01968-1",
"O15056-1",
"P13569-1",
"O75061-1",
"O43426-1"
],
"evidence": [
{
"id": "R-HSA-8868660",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8868660"
}
]
},
{
"id": "R-HSA-888589",
"name": "Release of GABA at the synapse",
"equation": "",
"summary": "GABA synaptic vesicles are fused to the presynaptic terminal membrane with the help of SNARE complex proteins, synaptobrevin located in the synaptic vesicle, SNAP 25 and syntaxin located in the plasma membrane. Complexin optimizes partially assembled SNARES for Ca2+ dependent exocytosis. Fusion of the synaptic vesicle is triggered by the influx of Ca2+ through N, P/Q Ca2+ channels, which binds to synaptobrevin on the synaptic vesicles triggering a series of steps leading to fusion of the synaptic vesicle to the presynatic terminal membrane and release of GABA.",
"cellular_location": "cytosol, extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-352003",
"R-HSA-210407",
"R-HSA-917998",
"R-HSA-936508",
"R-HSA-936512"
],
"enzyme_list": [
"P11142-1",
"Q99259-1",
"Q05329-1"
],
"evidence": [
{
"id": "R-HSA-888589",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-888589"
}
]
},
{
"id": "R-HSA-8932221",
"name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8",
"equation": "",
"summary": "Protein N-lysine methyltransferase METTL21A trimethylates lysine-561 of Heat shock cognate 71 kDa protein (HSPA8) and corresponding lysine residues in other Hsp70 isoforms (Jakobsson et al. 2013, Cloutier et al. 2013).",
"cellular_location": "nucleoplasm",
"input_participant_list": [
"R-HSA-5082380"
],
"output_participant_list": [
"R-HSA-8932217"
],
"enzyme_list": [
"P11142-1",
"Q8WXB1-1"
],
"evidence": [
{
"id": "R-HSA-8932221",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8932221"
}
]
},
{
"id": "R-HSA-917744",
"name": "GABA loaded synaptic vesicle Docking and Priming",
"equation": "",
"summary": "GABA loaded synaptic vesicles are docked at the presynaptic terminal membrane by a number of proteins including Rab3a, RIM (Rab3a interaction protein) and Munc 13. The docked GABA vesicles are primed by the SNARE complex that includes synaptobrevin, SNAP 25 and syntaxin1.",
"cellular_location": "plasma membrane, clathrin-sculpted gamma-aminobutyric acid transport vesicle",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q99259-1",
"Q05329-1"
],
"evidence": [
{
"id": "R-HSA-917744",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-917744"
}
]
},
{
"id": "R-HSA-9613352",
"name": "PLINs bind HSPA8",
"equation": "",
"summary": "Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. A key step in this process is the elimination of perilipin (PLIN) proteins on lipid droplet surface. This mechanism is initiated when the cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Consequently, perilipins are phosphorylated and targeted to degradation making the lipid available for hydrolysis (S Kaushik et al. 2015). Experiments confirming this interaction were performed in rats.",
"cellular_location": "cytosol, lipid droplet",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-9613352",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9613352"
}
]
},
{
"id": "R-HSA-9613513",
"name": "PLINs:HSPA8 binds PRKAA2",
"equation": "",
"summary": "Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (PLIN) protiens and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Consequently, PRKAA2 bind and phosphorylate perilipins targeting them for lipophagy (S Kaushik et al. 2015, S Kaushik et al. 2016). Experiments confirming this interaction were performed in mouse.",
"cellular_location": "cytosol, lipid droplet",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P54646-1",
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-9613513",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9613513"
}
]
},
{
"id": "R-HSA-9613530",
"name": "PRKAA2 phosphorylates PLINs",
"equation": "",
"summary": "Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (PLIN) proteins and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Subsequently, AMPK binds and phosphorylates perilipins targeting them for lipophagy (S Kaushik et al. 2015, S Kaushik et al. 2016). The precise phosphorylation site(s) on PLINs are unknown. Experiments confirming this finding were performed in mouse models.",
"cellular_location": "cytosol, lipid droplet",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P54646-1",
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-9613530",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9613530"
}
]
},
{
"id": "R-HSA-9613565",
"name": "PRKAA2 dissociate from p-PLINs:HSPA8",
"equation": "",
"summary": "Once phosphorylated, PLINs are believed to dissociate from PRKAA2 and translocate to the cytosol (S Kaushik et al. 2015, S Kaushik et al. 2016). The precise dissociation mechanism of Plins is unclear. The experiments showing this finding were performed in mouse models.",
"cellular_location": "cytosol, lipid droplet",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P54646-1",
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-9613565",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9613565"
}
]
},
{
"id": "R-HSA-9613666",
"name": "p-PLINs translocate from lipid droplet surface to cytosol",
"equation": "",
"summary": "Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (PLIN) proteins and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Subsequently, PRKAA2 binds and phosphorylates perilipins. Phosphorylated PLINs dissociate from PRKAA2 and are believed to translocate to the cytosol (S Kaushik et al. 2015, S Kaushik et al. 2016). Experiments suggesting this event were performed in mouse models.",
"cellular_location": "cytosol, lipid droplet",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-9613666",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9613666"
}
]
},
{
"id": "R-HSA-9615721",
"name": "HSPA8 binds substrate",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) acts as the constitutive chaperone that binds substrate proteins in the cytosol. HSPA8 recognizes a motif based on the charge of the amino acids (Chiang H et al. 1989, Dice JF et al. 1990). This allows the motif to have multiple sequence possibilities and also create a motif through post-translational modifications such as phosphorylation and acetylation. Once bound with HSPA8, the substrates are targeted to the lysosome or endosome.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9615721",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9615721"
}
]
},
{
"id": "R-HSA-9620197",
"name": "HSPA8:Substrate binds LAMP2a",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) acts as the constitutive chaperone that binds substrates in the cytosol. Consequently, the Hspa8:Substrate complex translocates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a) (Cuervo AM and Dice JF. 1996). Four positively charged amino acids in the cytosolic tail of the LAMP2a isoform is known to regulate the binding mechanism (Cuervo AM and Dice JF. 2000). Experiments confirming this binding were performed on rat models.",
"cellular_location": "cytosol, lysosomal membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9620197",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9620197"
}
]
},
{
"id": "R-HSA-9622840",
"name": "HSPA8 dissociates from LAMP2A-bound substrate",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) acts as the constitutive chaperone that binds KFERQ-domain containing substrates in the cytosol. Consequently, the Hspa8:Substrate complex translocates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Post-binding, HSPA8 is released from the complex to allow multimerization of LAMP2a and internalization of the substrate (Bandyopadhyay U et al. 2008). Experiments confirming this binding were performed on rat models.",
"cellular_location": "cytosol, lysosomal membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9622840",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9622840"
}
]
},
{
"id": "R-HSA-9625188",
"name": "HSPA8 transports unfolded substrate to lysosomal lumen for degradation",
"equation": "",
"summary": "Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from the cytosol to the lysosomal membrane. Subsequently, the substrate unfolds and binds to HSPA8 in the lysosomal lumen. HSPA8 facilitates the transport of the unfolded substrate to the lumen where it is then degraded (Agarraberes FA et al. 1997, Cuervo AM et al. 1997).",
"cellular_location": "lysosomal membrane, lysosomal lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9625188",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9625188"
}
]
},
{
"id": "R-HSA-9625196",
"name": "Unfolded substrate in LAMP2a multimeric complex binds HSPA8",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) acts as the constitutive chaperone that binds a KFERQ-domain containing substrate in the cytosol and translocates to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Subsequently, Hspa8 is released and Heat shock protein HSP90 binds to the lysosomal luminal end of LAMP2a. The LAMP2a complex then multimerizes and stabilizes. Now, the substrate unfolds and binds to HSPA8 in the lysosomal lumen (Agarraberes FA et al. 1997, Cuervo AM et al. 1997). Subsequently, the substrate is internalized and degraded in the lumen. Experiments confirming this interaction were performed in rats.",
"cellular_location": "lysosomal membrane, lysosomal lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9625196",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9625196"
}
]
},
{
"id": "R-HSA-9626060",
"name": "HSPA8:Substrate dissociates from LAMP2a multimer",
"equation": "",
"summary": "Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). The LAMP2a complex then multimerizes and stabilizes. Subsequently, the substrate unfolds and translocates to the lumen. The substrate bound HSPA8 then dissociates from LAMP2a multimer (Agarraberes FA et al. 1997, Cuervo AM et al. 1997). The function of LAMP2a multimer is now complete and starts to disassemble.",
"cellular_location": "lysosomal membrane, lysosomal lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9626060",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9626060"
}
]
},
{
"id": "R-HSA-9626235",
"name": "HSPA8 dissociates from LAMP2a",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) transports substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Subsequently, LAMP2a forms a multimeric complex and transfers the substrate into the lumen. The stability of this complex is regulated by the dynamics of HSPA8. Cytosolic HSPA8 binds with LAMP2a multimers in the lysosomal membrane and triggers their disassembly into monomeric units (Bandyopadhyay U et al. 2008). HSPA8 dissociates from LAMP2a to make it available for further substrate autophagy. Experiments related to this event were performed in rats.",
"cellular_location": "cytosol, lysosomal membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1"
],
"evidence": [
{
"id": "R-HSA-9626235",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9626235"
}
]
},
{
"id": "R-HSA-9626253",
"name": "HSPA8 binds LAMP2a multimers",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) transports substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Subsequently, LAMP2a forms a multimeric complex and transfers the substrate into the lumen. The stability of this complex is regulated by the dynamics of HSPA8. Cytosolic HSPA8 binds with LAMP2a multimers in the lysosomal membrane and triggers their disassembly. Interestingly, substrate bound HSPA8 do not have this effect on LAMP2a (Bandyopadhyay U et al. 2008). Experiments confirming this event were performed in rats.",
"cellular_location": "cytosol, lysosomal membrane",
"input_participant_list": [
"R-HSA-9626026",
"R-HSA-264476"
],
"output_participant_list": [
"R-HSA-9626247"
],
"enzyme_list": [
"P11142-1",
"P07900-1"
],
"evidence": [
{
"id": "R-HSA-9626253",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9626253"
}
]
},
{
"id": "R-HSA-9626256",
"name": "HSPA8:LAMP2a multimers depolymerizes to monomers",
"equation": "",
"summary": "Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) transports substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Subsequently, LAMP2a forms a multimeric complex and transfers the substrate into the lumen. The stability of this complex is regulated by the dynamics of HSPA8. Cytosolic HSPA8 binds with LAMP2a multimers in the lysosomal membrane. This triggers the disassembly of multimeric complexes into monomeric units (Bandyopadhyay U et al. 2008). Experiments confirming this event were performed in rats.",
"cellular_location": "cytosol, lysosomal membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P07900-1"
],
"evidence": [
{
"id": "R-HSA-9626256",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9626256"
}
]
},
{
"id": "R-HSA-9631065",
"name": "Substrate translocates into late endosomal lumen",
"equation": "",
"summary": "In addition to bulk protein degradation, Microautophagy (MI) can also target KFERQ motif protein substrates similar to Chaperone Mediated Autophagy (CMA). However, MI is distinct from CMA in that it occurs during late endosomes/multivesicular bodies formation. Upon binding with Hspa8, substrates are transported from the cytosol to late endosomes. HSPA8 binds with the phospholipids on the late endosomal membrane. Subsequently, the substrate is transported into the lumen via endosomal sorting complexes required for transport (ESCRTI and ESCRTIII systems) (Sahu R et al. 2011). This event is represented as a black box since the precise molecular mechanism of the substrate transport into the endosomal lumen is unclear. Experiments confirming this event were performed in mouse.",
"cellular_location": "cytosol, late endosome membrane, late endosome lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9631065",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9631065"
}
]
},
{
"id": "R-HSA-9631068",
"name": "HSPA8:substrate binds late endosomal phospholipids",
"equation": "",
"summary": "Microautophagy (MI) can target KFERQ motif containing protein substrates to endosomal degradation. Upon binding with HSPA8, substrates are transported from the cytosol to late endosomes. Here, HSPA8 binds with the phospholipids on the late endosomal membrane. This interaction facilitates the vesicle-mediated transport of HSPA8:substrate complex into the late endosomes for degradation (Sahu R et al. 2011). Experiments confirming this interaction were performed in mouse cells.",
"cellular_location": "cytosol, late endosome membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q99497-1",
"Q9UBN7-1",
"P07998-1",
"P13569-1"
],
"evidence": [
{
"id": "R-HSA-9631068",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9631068"
}
]
},
{
"id": "R-HSA-9770131",
"name": "Formation of the Spliceosomal B* complex",
"equation": "",
"summary": "DHX16 (homolog of yeast Prp2) hydrolyzes ATP in the Spliceosomal Bact complex to form the Spliceosomal B* complex (Gencheva et al. 2010), possibly by pulling the intron to dissociate the RES complex and the SF3A and SF3B subcomplexes of the U2 snRNP from the spliceosome (Bessonov et al. 2010, Agafonov et al. 2011, Schmidt et al. 2014, Kastner et al. 2019). The intron branch point now docks near the 5' splice site (Zhan et al. 2018), displacing RNF113A (homolog of yeast Cwc24) (Schmidt et al. 2014, Zhan et al. 2018). YJU2 and ISY1 bind and distort the helix of the branch point to fit the active site (Zhan et al. 2018). Prior to the transesterification reaction between the adenosine residue of the intron branch point and the 5' splice site, the complex is called the Spliceosomal B* complex.
Components of the core exon junction complex (EJC) comprising EIF4A3, CASC3, MAGOH, and RBM8A are recruited to the spliceosome around this time (Kataoka and Dreyfuss 2004) by an interaction between CWC22 and EIF4A3 (Reichert et al. 2002, Alexandrov et al. 2012, Barbosa et al. 2012, Steckelberg et al. 2012, Busetto et al. 2020), though they may not yet bind RNA. CWC27 must be displaced in order for RBM8A (Y14) to bind (Busetto et al. 2020). Due to the position of CWC22 in the spliceosome, the EJC will be deposited on the 5' exon about 20-24 nucleotides upstream of the 5' splice site. The components and formation of the spliceosomal B* complex are partly inferred from the composition of the spliceosomal C complex (Jurica et al. 2002, Makarov et al. 2002, Rappsilber et al. 2002, Reichert et al. 2002, Bessonov et al. 2010, Agafonov et al. 2011, Schmidt et al. 2014, Zhan et al. 2018, Kastner et al. 2019).",
"cellular_location": "nucleoplasm",
"input_participant_list": [
"R-HSA-156776",
"R-HSA-72060",
"R-HSA-8849148",
"R-HSA-8867884",
"R-HSA-8867893",
"R-HSA-8867898",
"R-HSA-8952113",
"R-HSA-9769592",
"R-HSA-9770419",
"R-HSA-9770425",
"R-HSA-9770427",
"R-HSA-9770428",
"R-HSA-9770430"
],
"output_participant_list": [
"R-HSA-2396419",
"R-HSA-71967",
"R-HSA-71976"
],
"enzyme_list": [
"O75643-1",
"Q86XP3-1",
"Q13356-1",
"Q96BP3-1",
"Q9H2H8-1",
"O15541-1",
"P11142-1",
"P24928-1",
"O60306-1",
"Q9UNP9-1",
"P38919-1",
"Q13838-1",
"Q9Y3C6-1",
"Q8WUA2-1",
"Q13427-1",
"Q7L014-1",
"P30876-1",
"O60231-1",
"Q92620-1",
"P42285-1",
"P17844-1",
"O43143-1",
"Q9H5Z1-1",
"Q9UMS4-1"
],
"evidence": [
{
"id": "R-HSA-9770131",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770131"
}
]
},
{
"id": "R-HSA-9770141",
"name": "Formation of the Spliceosomal C* complex",
"equation": "",
"summary": "DHX38 (homolog of yeast Prp16) hydrolyzes ATP to remodel the Spliceosomal C complex to the Spliceosomal C* complex (Ortlepp et al. 1998, Zhou and Reed 1998), which will ligate the exons and produce the intron lariat, yielding the Spliceosomal P (post-catalytic) complex. DHX38 appears to dissociate shortly after remodeling the Spliceosomal C complex (Zhang et al. 2017, Kastner et al. 2019). Catalysis of exon ligation will occur in the same active site as branching occurred. Therefore, the pre-mRNA must be moved relative to the active site. DHX38 binds the pre-mRNA downstream of the intron branch point, displaces YJU2 and CWC25, and rotates the branch helix out of the active site to allow the 3' splice junction to enter (Bertram et al. 2017, Zhang et al. 2017). The branch helix is stabilized after re-positioning by CDC40 (homolog of yeast Prp17) bound to the 5' stem-loop of the U6 snRNA and PRPF8 (homolog of yeast Prp8) of the U5 snRNP (Bertram et al. 2017, Zhang et al. 2017). SLU7 and PRPF18 (homolog of yeast Prp18) are components of the Spliceosomal C* complex and participate in docking the 3' splice site in the active site (Bertram et al. 2017, Zhang et al. 2017). The 3' end of the upstream exon base-pairs with loop I of U5 snRNA and the branch point region of the intron base-pairs with the U2 snRNA and U6 snRNA (Bertram et al. 2017, Zhang et al. 2017). As in yeast (Wilkinson et al. 2017), the 3' splice site may form non-Watson-Crick base pairs with the 5' splice site and branch point of the intron. The 3' splice site may also interact with SLU7 (Bertram et al. 2017, Zhang et al. 2017), PRPF18 (homolog of yeast Prp18), and DHX8 (homolog of yeast Prp22). As in the Bact complex, the catalytic magnesium ions of the active Spliceosomal C complex are coordinated by phosphates of the U6 snRNA (Bertram et al. 2017, Zhang et al. 2017). The components of the Spliceosomal C* complex have been ascertained using proteomic and structural methods (Jurica et al. 2002, Makarov et al. 2002, Rappsilber et al. 2002, Ilagan et al. 2013, Bertram et al. 2017, Zhang et al. 2017, Kastner et al. 2019, also inferred from yeast homologs in Fica et al. 2017). Mutations in DHX38 affect splicing and can cause retinitis pigmentosa (Ajmal et al. 2014, Obuca et al. 2022).",
"cellular_location": "nucleoplasm",
"input_participant_list": [
"R-HSA-72073",
"R-HSA-9769591",
"R-HSA-9769593",
"R-HSA-9769594",
"R-HSA-9769596",
"R-HSA-9769598",
"R-HSA-9769599",
"R-HSA-9769601"
],
"output_participant_list": [],
"enzyme_list": [
"O75643-1",
"Q13356-1",
"Q96BP3-1",
"Q9H2H8-1",
"P11142-1",
"P24928-1",
"O60306-1",
"Q9UNP9-1",
"P38919-1",
"Q14562-1",
"Q13838-1",
"Q9Y3C6-1",
"Q8WUA2-1",
"Q13427-1",
"Q7L014-1",
"P30876-1",
"Q92620-1",
"P42285-1",
"P17844-1",
"O43143-1",
"Q9H5Z1-1",
"Q9UJV9-1",
"Q9UMS4-1"
],
"evidence": [
{
"id": "R-HSA-9770141",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770141"
}
]
},
{
"id": "R-HSA-9770145",
"name": "Formation of the Spliceosomal Bact complex",
"equation": "",
"summary": "Activation of the Spliceosomal B complex to form the Spliceosomal Bact complex is believed to occur in several complex steps. SNRNP200 (homolog of yeast Brr2) of the U5 snRNP uses ATP to dissociate the U4 snRNP from the spliceosome. This renders U6 snRNA free to form additional interactions with U2 snRNA and fold its internal stem loop to create the active site (Laggerbauer et al. 1998, Lamond et al. 1988, Bessonov et al. 2010, Agafonov et al. 2011, Fica et al. 2013, Galej et al. 2016, Haselbach et al. 2018, Zhang et al. 2018, Kastner et al. 2019). In this active site four phosphate groups of the U6 snRNA cooridinate the two magnesium ions that catalyze both transesterification reactions of pre-mRNA splicing..The PRP19-CDC5L complex (Ajuh et al. 2000, also called the NTC complex) and the PRP19-CDC5L related complex (also called the NTR complex) are recruited during this transition and stabilize the active site (Bessonov et al. 2010, Agafonov et al. 2011, Haselbach et al. 2018, Zhang et al. 2018, Kastner et al. 2019). Splicing does not yet occur because the SF3B1 subunit of the U2 snRNP blocks the branch point and SF3A2 and RNF113A protect the 5' splice site, preventing the intron branch point from reacting with the 5' splice site (Gozani et al. 1996, Gozani et al. 1998, Haselbach et al. 2018, Zhang et al. 2018, Tholen et al. 2022). SNRNP200 and the RES complex retain the SF3B subcomplex in the spliceosome (Haselbach et al. 2018, Zhang et al. 2018). CWC22 recruits EIF4A3, which will form the exon junction complex (EJC) (Busetto et al. 2020) . The components of the Spliceosomal Bact complex have been ascertained using proteomic and structural methods (Bessonov et al. 2010, Agafonov et al. 2011, Haselbach et al. 2018, Zhang et al. 2018, Kastner et al. 2019, Townsend et al. 2020).",
"cellular_location": "nucleoplasm",
"input_participant_list": [
"R-HSA-8849149",
"R-HSA-8850837",
"R-HSA-8850839",
"R-HSA-8865956",
"R-HSA-8867885",
"R-HSA-8867892",
"R-HSA-8952110",
"R-HSA-9769561",
"R-HSA-9769562",
"R-HSA-9769563"
],
"output_participant_list": [
"R-HSA-3246027",
"R-HSA-53517",
"R-HSA-71875",
"R-HSA-71881"
],
"enzyme_list": [
"O75643-1",
"Q86XP3-1",
"Q13356-1",
"Q9H2H8-1",
"O15541-1",
"P11142-1",
"Q08211-1",
"P24928-1",
"O60306-1",
"Q9UNP9-1",
"P38919-1",
"Q13838-1",
"Q9Y3C6-1",
"Q7L014-1",
"P30876-1",
"O60231-1",
"Q9BUQ8-1",
"P42285-1",
"P17844-1",
"O43143-1",
"Q9UMS4-1",
"O43447-1"
],
"evidence": [
{
"id": "R-HSA-9770145",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770145"
}
]
},
{
"id": "R-HSA-9770236",
"name": "Formation of the Spliceosomal P complex and exon ligation",
"equation": "",
"summary": "Two magnesium ions coordinated by 4 phosphate groups of the U6 snRNA in the Spliceosomal C* complex (Bertram et al. 2017, Zhang et al. 2017) catalyze the transesterification reaction between the 3' nucleotide residue of the upstream exon and the 5' nucleotide residue of the downstream exon. The 3' hydroxyl group of the upstream exon nucleophilically attacks the 5' phosphate group of the downstream exon and the magnesium ions stabilize the pentacovalent transition state. Upon completion of exon ligation, the Spliceosomal P complex (post-catalytic complex) is formed. CACTIN, SDE2, NKAP, and PKRIP1 originally present in the Spliceosomal C* complex stabilize the branch helix (Fica et al. 2019, Zhang et al. 2019). FAM32A, not found in yeast, bridges the upstream exon and the 3' splice site of the intron in the Spliceosomal P complex (Fica et al. 2019). An Exon Junction Complex (EJC) is bound to the upstream exon 20-24 nucleotides upstream of the splice site (Zhang and Krainer 2007, Zhang et al. 2019). SRRM2 and CWC22 are also bound to the upstream exon (Zhang et al. 2019). ALYREF, which was initially recruited to the cap binding complex of the early spliceosome, now becomes associated with EJCs and nearby regions on the spliced mRNA (Zhou et al. 2000, Chi et al. 2013). Auxiliary factors, the ASAP complex or the PSAP complex also bind the EJC (Tange et al. 2005). DHX8 (homolog of yeast Prp22) which will dissociate the spliced mRNP from the Intron Lariat Spliceosome is bound to PRPF8 (homolog of yeast Prp8) (Zhang et al. 2019). The components of the Spliceosomal P complex have been ascertained using proteomic and structural methods (Kataoka and Dreyfuss 2004, Ilagan et al. 2013, Fica et al. 2019).",
"cellular_location": "nucleoplasm",
"input_participant_list": [
"R-HSA-9769588",
"R-HSA-9769590",
"R-HSA-9769602"
],
"output_participant_list": [
"R-HSA-5688093"
],
"enzyme_list": [
"O75643-1",
"Q13356-1",
"Q96BP3-1",
"Q9H2H8-1",
"P11142-1",
"P24928-1",
"O60306-1",
"Q9UNP9-1",
"P38919-1",
"Q14562-1",
"Q13838-1",
"Q9Y3C6-1",
"Q8WUA2-1",
"Q13427-1",
"Q7L014-1",
"P30876-1",
"P42285-1",
"P17844-1",
"O43143-1",
"Q9UJV9-1",
"Q9UMS4-1"
],
"evidence": [
{
"id": "R-HSA-9770236",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770236"
}
]
},
{
"id": "R-HSA-9770847",
"name": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)",
"equation": "",
"summary": "DHX8 (homolog of yeast Prp22) hydrolyzes ATP and translocates along the RNA in a 3' to 5' direction (Felisberto-Rodrigues et al. 2019) to release the spliced mRNA and associated proteins (Merz et al. 2007), including the exon junction complex (EJC), from the Spliceosomal P complex (Ohno and Shimura 1996, Zhang et al. 2019). After the second splicing reaction, DHX8 interacts with CACTIN and SRRM2 in the Spliceosomal P complex and is bound to the 3' exon downstream of the 3' splice site. As DHX8 translocates along the RNA, it is thought to pull the 3' end of the spliced exon and dissociate the spliced exon from the U5 snRNA. SLU7 and PRPF18 are also dissociated from the spliceosome at this time. The intron lariat remains bound to the intron lariat spliceosome (ILS) (Yoshimoto et al. 2009). TFIP11 (homolog of yeast Ntr1) is present in the ILS (Yoshimoto et al. 2009) and recruits DDX15 (homolog of yeast Prp43) to disassemble the ILS.",
"cellular_location": "nucleoplasm",
"input_participant_list": [
"R-HSA-5688097",
"R-HSA-8869310",
"R-HSA-8869311",
"R-HSA-9770846"
],
"output_participant_list": [
"R-HSA-3900136",
"R-HSA-5688092",
"R-HSA-6814858",
"R-HSA-8865888"
],
"enzyme_list": [
"O75643-1",
"Q96BP3-1",
"Q9H2H8-1",
"P11142-1",
"P24928-1",
"O60306-1",
"Q9UNP9-1",
"P38919-1",
"Q14562-1",
"Q9Y3C6-1",
"Q13427-1",
"Q7L014-1",
"P30876-1",
"P17844-1",
"O43143-1",
"Q9UJV9-1",
"Q9UMS4-1"
],
"evidence": [
{
"id": "R-HSA-9770847",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770847"
}
]
},
{
"id": "R-HSA-9772351",
"name": "Disassembly of the Intron Lariat Spliceosome (new)",
"equation": "",
"summary": "DHX15 (the homolog of yeast Prp43) hydrolyzes ATP (Studer et al. 2020) and translocates along U6 snRNA (inferred from yeast Prp43 in Toroney et al. 2019) to release the lariat intron from the Intron Lariat Spliceosome (ILS) (Yoshimoto et al. 2009). TFIP11 (homolog of yeast Ntr1) and GCFC2 (C2ORF3, homolog of yeast Ntr2) bind and stimulate DHX15 activity (Wen et al. 2008, Yoshimoto et al. 2014). The disassembly process is observed as a shift from the ILS to the Intron Small complex., which contains the lariat intron and some undefined proteins (Yoshimoto et al. 2009). The PRP19-CDC5L complex (NTC), the PRP19-CDC5L related complex (NTR), the U5 snRNP, U2 12S snRNP, and U6 snRNA are released and reused in subsequent splicing reactions (Yoshimoto et al. 2009).The intron lariat is debranched (linearized) by the 2'-5' phosphodiesterase DBR1 (Kataoka et al. 2013) and then degraded by specific decay machineries.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [
"R-HSA-8869309"
],
"enzyme_list": [
"O75643-1",
"P11142-1",
"O60306-1",
"Q9UNP9-1",
"Q9Y3C6-1",
"Q7L014-1",
"O43143-1",
"Q9UMS4-1"
],
"evidence": [
{
"id": "R-HSA-9772351",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9772351"
}
]
},
{
"id": "R-HSA-9828639",
"name": "Transcription of respiratory syncytial virus subgenomic positive sense mRNAs",
"equation": "",
"summary": "The RNA-dependent RNA polymerase complex (RdRP) of the human respiratory syncytial virus (RSV) is composed of large polymerase subunit L, which harbors catalytic activity, phosphoprotein polymerase cofactor subunit P, and transcription processivity factor M2-1. RdRP transcribes the RSV's negative sense, single-stranded RNA (-ssRNA) genome into 10 positive sense messenger RNAs that encode 11 viral proteins. The 10 viral mRNAs are: 1C (NS1) mRNA, 1B (NS2) mRNA, N mRNA, P mRNA, M mRNA, SH mRNA, G mRNA, F mRNA, M2 mRNA, and L mRNA. UV-based mapping shows that the 10 RSV genes are transcribed as a single transcriptional unit, with transcription of an individual gene depending on the prior transcription of all preceding genes (Dickens et al. 1984). The genomic RNA contains the 3' leader region of 44 nucleotides and the 5' trailer region, which are important for transcription initiation and termination, respectively. In addition, each RSV gene is preceded by a conserved GS (gene-start) motif and followed by a conserved GE (gene-end) motif, which regulate initiation and termination of transcription, respectively, of individual genes (Kuo et al. 1996; Kuo et al. 1997). GS signals in conjunction with nucleotides 36-45 of the 3' leader region are sufficient to direct accurate initiation of mRNA synthesis, with spacing between transcription signals being important (McGivern et al. 2005). M2-1 acts as a transcription processivity factor and its function depends on the Cys3-His1 motif consisting of 3 conserved cysteine residues C7, C15, and C21 and one conserved histidine residue, H25 (Tang et al. 2001).
NS1 mRNA is transcribed from the NS1 gene at the very 3' end of the RSV genome (Dickens et al. 1984, Collins and Wertz 1985, Evans et al. 1996) while NS2 mRNA is transcribed from the NS2 gene, located 5' terminally to the NS1 gene (Dickens et al. 1984, Venkatesan et al. 1983, Collins and Wertz 1985, Evans et al. 1996). While individual NS1 and NS2 mRNAs are thought to predominate, a dicistronic mRNA, containing both the NS1 and NS2 mRNA sequences separated by an intergenic sequence, has been reported (Collins and Wertz 1985). N mRNA is transcribed from the N gene (Venkatesan et al. 1983, Dickens et al. 1984). P mRNA is transcribed from the P gene (Venkatesan et al. 1983, Dickens et al. 1984). M mRNA is transcribed from the M gene (Venkatesan et al. 1983, Satake and Venkatesan 1984, Dickens et al. 1984). SH mRNA is transcribed from the SH gene (Dickens et al. 1984). G mRNA is transcribed from the G gene (Dickens et al. 1984). F mRNA is transcribed from the F gene (Dickens et al. 1984, Elango et al. 1985). M2 mRNA is transcribed from the M2 gene (Collins et al. 1987, Kuo et al. 1996, Fearns and Collins 1999). Dicistronic mRNAs F-M2 and M2-L as well as polycistronic G-F-M2 mRNA can also be detected (Fearns and Collins 1999). L mRNA is transcribed from the L gene (Collins et al. 1987, Kuo et al. 1996, Fearns and Collins 1999). As the GS motif of the L gene lies upstream of the GE motif of the M2 gene, the latter occupying nucleotides 56-68 of the L gene (Collins et al. 1987, Kuo et al. 1996), only a smaller portion of L gene transcripts are full-length polyadenylated mRNAs. A larger portion are truncated polyadenylated transcripts (Collins et al. 1987). Full-length L mRNA is present at ~1/6 of the level of M2 mRNA throughout the course of infection (Fearns and Collins 1999). Dicistronic M2-L mRNA can also be detected (Fearns and Collins 1999).
Heat shock protein HSPA8 (HSC70) positively regulates transcription of viral mRNAs (Munday et al. 2015), consistent with previous reports that RSV transcription requires, in addition to the RdRP complex, the presence of host cell factors (Barik 1992).
M2-2 promotes the switch from transcription of viral genes to replication of the viral genome for virion assembly (Bermingham et and Collins 1999). M2-2-mediated inhibition of transcription may require phosphorylation of the P protein on particular sites (Asenjo and Villanueva 2016).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1"
],
"evidence": [
{
"id": "R-HSA-9828639",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9828639"
}
]
},
{
"id": "R-HSA-9833723",
"name": "PKR forms a dimer",
"equation": "",
"summary": "PKR (EIF2AK2) exists in a weak monomer/dimer equilibrium and, only when its catalytic domain is activated, acts as protein kinase. Dimerization-defective mutants of PKR cannot be activated by dsRNA. Apparently dsRNA and protein activators facilitate PKR dimerization which is the prerequisite for its autophosphorylation (Wu & Kaufman, 1997; Patel & Sen, 1995; Tian and Mathews 2001; Dey et al, 2005; Husain et al, 2015; reviewed by Cole, 2006).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NX74-1",
"P11142-1",
"Q9NW38-1",
"Q9NYA1-1",
"P55265-1",
"P19525-1",
"Q8IYD8-1"
],
"evidence": [
{
"id": "R-HSA-9833723",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833723"
}
]
},
{
"id": "R-HSA-9835411",
"name": "FA core complex:HSP70s binds PKR",
"equation": "",
"summary": "Fanconi anemia group C protein (FANCC), as part of a complex of the Fanconi anemia core complex with HSP70 proteins, binds to PKR inhibiting its activation (Pang et al, 2001a; Pang et al, 2001b; Pang et al, 2002). PKR is constitutively activated in cells with mutations in the Fanconi anemia genes FANCA, FANCC, and FANCG, leading to hypersensitivity of bone marrow progenitor cells to growth repression and cell death (Zhang et al, 2004).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"Q9NW38-1",
"P19525-1",
"Q8IYD8-1"
],
"evidence": [
{
"id": "R-HSA-9835411",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9835411"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-352003",
"participant_name": "GABA [extracellular region]",
"crossref": [
{
"id": "59888",
"database": "ChEBI",
"url": ""
},
{
"id": "56-12-2",
"database": "CAS",
"url": ""
},
{
"id": "000001532620",
"database": "ZINC",
"url": ""
},
{
"id": "C00334",
"database": "KEGG Gene",
"url": ""
},
{
"id": "6992099",
"database": "PubChem Compound",
"url": ""
},
{
"id": "4-AMINO-BUTYRATE",
"database": "AraCyc",
"url": ""
},
{
"id": "000001532620",
"database": "ZINC",
"url": ""
},
{
"id": "6992099",
"database": "PubChem Compound",
"url": ""
},
{
"id": "59888",
"database": "ChEBI",
"url": ""
},
{
"id": "4-AMINO-BUTYRATE",
"database": "AraCyc",
"url": ""
},
{
"id": "C00334",
"database": "KEGG Gene",
"url": ""
},
{
"id": "56-12-2",
"database": "CAS",
"url": ""
},
{
"id": "000001532620",
"database": "ZINC",
"url": ""
},
{
"id": "6992099",
"database": "PubChem Compound",
"url": ""
},
{
"id": "59888",
"database": "ChEBI",
"url": ""
},
{
"id": "56-12-2",
"database": "CAS",
"url": ""
},
{
"id": "4-AMINO-BUTYRATE",
"database": "AraCyc",
"url": ""
},
{
"id": "C00334",
"database": "KEGG Gene",
"url": ""
},
{
"id": "000001532620",
"database": "ZINC",
"url": ""
},
{
"id": "6992099",
"database": "PubChem Compound",
"url": ""
},
{
"id": "59888",
"database": "ChEBI",
"url": ""
},
{
"id": "C00334",
"database": "KEGG Gene",
"url": ""
},
{
"id": "4-AMINO-BUTYRATE",
"database": "AraCyc",
"url": ""
},
{
"id": "56-12-2",
"database": "CAS",
"url": ""
},
{
"id": "56-12-2",
"database": "CAS",
"url": ""
},
{
"id": "C00334",
"database": "KEGG Gene",
"url": ""
},
{
"id": "4-AMINO-BUTYRATE",
"database": "AraCyc",
"url": ""
},
{
"id": "000001532620",
"database": "ZINC",
"url": ""
},
{
"id": "59888",
"database": "ChEBI",
"url": ""
},
{
"id": "6992099",
"database": "PubChem Compound",
"url": ""
}
]
},
{
"participant_id": "R-HSA-156776",
"participant_name": "UPF3B [nucleoplasm]",
"crossref": [
{
"id": "Q9BZI7",
"database": "UniProt",
"url": ""
},
{
"id": "1UW4",
"database": "PDB",
"url": ""
},
{
"id": "2XB2",
"database": "PDB",
"url": ""
},
{
"id": "NP_542199.1",
"database": "RefSeq",
"url": ""
},
{
"id": "17318",
"database": "Orphanet",
"url": ""
},
{
"id": "Q9BZI7",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000125351-UPF3B",
"database": "HPA",
"url": ""
},
{
"id": "NP_075386.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000125351",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q9BZI7",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000345865",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000125351",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9BZI7",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000276201",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000276201",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000245418",
"database": "Ensembl",
"url": ""
},
{
"id": "7NWU",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-167717",
"participant_name": "AP-1 Complex [cytosol]",
"crossref": [
{
"id": "CPX-5047",
"database": "ComplexPortal",
"url": ""
},
{
"id": "CPX-5048",
"database": "ComplexPortal",
"url": ""
},
{
"id": "CPX-5050",
"database": "ComplexPortal",
"url": ""
},
{
"id": "CPX-5049",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-210407",
"participant_name": "RIMS1 [cytosol]",
"crossref": [
{
"id": "ENST00000522291",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000079841-RIMS1",
"database": "HPA",
"url": ""
},
{
"id": "ENSP00000264839",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000429959",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000411235",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000430502",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001161882.1",
"database": "RefSeq",
"url": ""
},
{
"id": "XP_011533917.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000428367",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000264839",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001161880.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000491071",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000079841",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q86UR5",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000430932",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000414192",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000401910",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001161883.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000523963",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000520567",
"database": "Ensembl",
"url": ""
},
{
"id": "Q86UR5",
"database": "UniProt",
"url": ""
},
{
"id": "Q86UR5",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000518273",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000517960",
"database": "Ensembl",
"url": ""
},
{
"id": "2CSS",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000521978",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000430101",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000385649",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000402273",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000428328",
"database": "Ensembl",
"url": ""
},
{
"id": "Q86UR5",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSP00000428417",
"database": "Ensembl",
"url": ""
},
{
"id": "HMDBP07972",
"database": "HMDB Protein",
"url": ""
},
{
"id": "15212",
"database": "Orphanet",
"url": ""
},
{
"id": "NP_001161879.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000425662",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000430408",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000517827",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_055804.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000079841",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001161881.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-2396419",
"participant_name": "MFAP1 [nucleoplasm]",
"crossref": [
{
"id": "5O9Z",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000140259",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_005917.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000140259",
"database": "OpenTargets",
"url": ""
},
{
"id": "7ABF",
"database": "PDB",
"url": ""
},
{
"id": "6AHD",
"database": "PDB",
"url": ""
},
{
"id": "P55081",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "7ABG",
"database": "PDB",
"url": ""
},
{
"id": "P55081",
"database": "UniProt",
"url": ""
},
{
"id": "7ABI",
"database": "PDB",
"url": ""
},
{
"id": "7AAV",
"database": "PDB",
"url": ""
},
{
"id": "5F5S",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000267812",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000140259-MFAP1",
"database": "HPA",
"url": ""
},
{
"id": "ENST00000267812",
"database": "Ensembl",
"url": ""
},
{
"id": "P55081",
"database": "PRO",
"url": ""
},
{
"id": "P55081",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-264470",
"participant_name": "ARRB1 [cytosol]",
"crossref": [
{
"id": "ENSG00000137486-ARRB1",
"database": "HPA",
"url": ""
},
{
"id": "ENSP00000409581",
"database": "Ensembl",
"url": ""
},
{
"id": "P49407",
"database": "GeneCards",
"url": ""
},
{
"id": "8AS2",
"database": "PDB",
"url": ""
},
{
"id": "7SRS",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000137486",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_064647.1",
"database": "RefSeq",
"url": ""
},
{
"id": "8AS4",
"database": "PDB",
"url": ""
},
{
"id": "7R0J",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000360025",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000137486",
"database": "OpenTargets",
"url": ""
},
{
"id": "P49407",
"database": "UniProt",
"url": ""
},
{
"id": "7R0C",
"database": "PDB",
"url": ""
},
{
"id": "6PWC",
"database": "PDB",
"url": ""
},
{
"id": "6TKO",
"database": "PDB",
"url": ""
},
{
"id": "P49407",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000353124",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_004032.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000420843",
"database": "Ensembl",
"url": ""
},
{
"id": "2IV8",
"database": "PDB",
"url": ""
},
{
"id": "8AS3",
"database": "PDB",
"url": ""
},
{
"id": "P49407",
"database": "PRO",
"url": ""
},
{
"id": "6UP7",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-264476",
"participant_name": "HSPA8 [cytosol]",
"crossref": [
{
"id": "5AQU",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000432083",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000453788",
"database": "Ensembl",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "P11142",
"database": "ZINC target",
"url": ""
},
{
"id": "3FZF",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "GeneCards",
"url": ""
},
{
"id": "5AQK",
"database": "PDB",
"url": ""
},
{
"id": "3FZH",
"database": "PDB",
"url": ""
},
{
"id": "5AQJ",
"database": "PDB",
"url": ""
},
{
"id": "NP_694881.1",
"database": "RefSeq",
"url": ""
},
{
"id": "XP_011541100.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3ESK",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "UniProt",
"url": ""
},
{
"id": "5AQL",
"database": "PDB",
"url": ""
},
{
"id": "3FZK",
"database": "PDB",
"url": ""
},
{
"id": "5AQM",
"database": "PDB",
"url": ""
},
{
"id": "3FZL",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "PRO",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "5AQP",
"database": "PDB",
"url": ""
},
{
"id": "3LDQ",
"database": "PDB",
"url": ""
},
{
"id": "24608",
"database": "Orphanet",
"url": ""
},
{
"id": "5AQO",
"database": "PDB",
"url": ""
},
{
"id": "5AQN",
"database": "PDB",
"url": ""
},
{
"id": "3FZM",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP13799",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5AQS",
"database": "PDB",
"url": ""
},
{
"id": "4H5R",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5AQQ",
"database": "PDB",
"url": ""
},
{
"id": "3M3Z",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "5AQR",
"database": "PDB",
"url": ""
},
{
"id": "4H5N",
"database": "PDB",
"url": ""
},
{
"id": "4H5V",
"database": "PDB",
"url": ""
},
{
"id": "2543",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "ENSG00000109971-HSPA8",
"database": "HPA",
"url": ""
},
{
"id": "5AQH",
"database": "PDB",
"url": ""
},
{
"id": "3AGZ",
"database": "PDB",
"url": ""
},
{
"id": "5AQI",
"database": "PDB",
"url": ""
},
{
"id": "NP_006588.1",
"database": "RefSeq",
"url": ""
},
{
"id": "6B1N",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "5AQG",
"database": "PDB",
"url": ""
},
{
"id": "3AGY",
"database": "PDB",
"url": ""
},
{
"id": "5AQF",
"database": "PDB",
"url": ""
},
{
"id": "6ZYJ",
"database": "PDB",
"url": ""
},
{
"id": "5AQV",
"database": "PDB",
"url": ""
},
{
"id": "4H5W",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000532636",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000534624",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000404372",
"database": "Ensembl",
"url": ""
},
{
"id": "6B1M",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "Ensembl",
"url": ""
},
{
"id": "4KBQ",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000437125",
"database": "Ensembl",
"url": ""
},
{
"id": "6B1I",
"database": "PDB",
"url": ""
},
{
"id": "4HWI",
"database": "PDB",
"url": ""
},
{
"id": "4H5T",
"database": "PDB",
"url": ""
},
{
"id": "5AQT",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-265269",
"participant_name": "PTGES3 [cytosol]",
"crossref": [
{
"id": "Q15185",
"database": "UniProt",
"url": ""
},
{
"id": "1EJF",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000110958-PTGES3",
"database": "HPA",
"url": ""
},
{
"id": "7KRJ",
"database": "PDB",
"url": ""
},
{
"id": "NP_001269530.1",
"database": "RefSeq",
"url": ""
},
{
"id": "HMDBP10674",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000110958",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q15185",
"database": "GeneCards",
"url": ""
},
{
"id": "7L7J",
"database": "PDB",
"url": ""
},
{
"id": "7L7I",
"database": "PDB",
"url": ""
},
{
"id": "1379",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "NP_001269533.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001269534.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q15185",
"database": "PRO",
"url": ""
},
{
"id": "Q15185",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_006592.3",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000414274",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001269531.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000436399",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000405299",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000414892",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001269532.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000448157",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000110958",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000262033",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000402385",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000262033",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-3246027",
"participant_name": "TCERG1 [nucleoplasm]",
"crossref": [
{
"id": "2N4T",
"database": "PDB",
"url": ""
},
{
"id": "2N4W",
"database": "PDB",
"url": ""
},
{
"id": "O14776",
"database": "PRO",
"url": ""
},
{
"id": "3Q1I",
"database": "PDB",
"url": ""
},
{
"id": "7ABF",
"database": "PDB",
"url": ""
},
{
"id": "2MWD",
"database": "PDB",
"url": ""
},
{
"id": "2DOF",
"database": "PDB",
"url": ""
},
{
"id": "2N4V",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000296702",
"database": "Ensembl",
"url": ""
},
{
"id": "2MWB",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000113649",
"database": "Ensembl",
"url": ""
},
{
"id": "2N4S",
"database": "PDB",
"url": ""
},
{
"id": "2DOE",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000394421",
"database": "Ensembl",
"url": ""
},
{
"id": "2N4U",
"database": "PDB",
"url": ""
},
{
"id": "2N4R",
"database": "PDB",
"url": ""
},
{
"id": "7ABG",
"database": "PDB",
"url": ""
},
{
"id": "O14776",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "2MWA",
"database": "PDB",
"url": ""
},
{
"id": "3HFH",
"database": "PDB",
"url": ""
},
{
"id": "NP_001035095.1",
"database": "RefSeq",
"url": ""
},
{
"id": "2KIS",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000296702",
"database": "Ensembl",
"url": ""
},
{
"id": "2DK7",
"database": "PDB",
"url": ""
},
{
"id": "2NNT",
"database": "PDB",
"url": ""
},
{
"id": "NP_006697.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000113649",
"database": "OpenTargets",
"url": ""
},
{
"id": "4FQG",
"database": "PDB",
"url": ""
},
{
"id": "O14776",
"database": "UniProt",
"url": ""
},
{
"id": "2E71",
"database": "PDB",
"url": ""
},
{
"id": "2KIQ",
"database": "PDB",
"url": ""
},
{
"id": "2MWE",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000377943",
"database": "Ensembl",
"url": ""
},
{
"id": "O14776",
"database": "GeneCards",
"url": ""
},
{
"id": "2MWF",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000113649-TCERG1",
"database": "HPA",
"url": ""
},
{
"id": "2MW9",
"database": "PDB",
"url": ""
},
{
"id": "2DOD",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-3900136",
"participant_name": "DDX5 [nucleoplasm]",
"crossref": [
{
"id": "NP_001307524.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P17844",
"database": "GeneCards",
"url": ""
},
{
"id": "P17844",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000403085",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000504794",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_004387.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000225792",
"database": "Ensembl",
"url": ""
},
{
"id": "P17844",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENST00000585111",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000108654-DDX5",
"database": "HPA",
"url": ""
},
{
"id": "4A4D",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000108654",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000676785",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000577922",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000108654",
"database": "OpenTargets",
"url": ""
},
{
"id": "P17844",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000450599",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000464337",
"database": "Ensembl",
"url": ""
},
{
"id": "3.6.4.13",
"database": "IntEnz",
"url": ""
},
{
"id": "ENSP00000463168",
"database": "Ensembl",
"url": ""
},
{
"id": "HMDBP11690",
"database": "HMDB Protein",
"url": ""
},
{
"id": "3FE2",
"database": "PDB",
"url": ""
},
{
"id": "NP_001307525.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000225792",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-443857",
"participant_name": "STIP1 [cytosol]",
"crossref": [
{
"id": "7KW7",
"database": "PDB",
"url": ""
},
{
"id": "3ESK",
"database": "PDB",
"url": ""
},
{
"id": "3FWV",
"database": "PDB",
"url": ""
},
{
"id": "P31948",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000168439-STIP1",
"database": "HPA",
"url": ""
},
{
"id": "2NC9",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000168439",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_006810.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1ELR",
"database": "PDB",
"url": ""
},
{
"id": "1ELW",
"database": "PDB",
"url": ""
},
{
"id": "P31948",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "P31948",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000351646",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000445957",
"database": "Ensembl",
"url": ""
},
{
"id": "2LNI",
"database": "PDB",
"url": ""
},
{
"id": "NP_001269582.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000305218",
"database": "Ensembl",
"url": ""
},
{
"id": "P31948",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000358794",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000168439",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000538945",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001269581.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000305958",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5082380",
"participant_name": "HSPA8 [nucleoplasm]",
"crossref": [
{
"id": "P11142",
"database": "UniProt",
"url": ""
},
{
"id": "5AQL",
"database": "PDB",
"url": ""
},
{
"id": "3FZK",
"database": "PDB",
"url": ""
},
{
"id": "5AQM",
"database": "PDB",
"url": ""
},
{
"id": "3FZL",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "PRO",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "5AQP",
"database": "PDB",
"url": ""
},
{
"id": "3LDQ",
"database": "PDB",
"url": ""
},
{
"id": "24608",
"database": "Orphanet",
"url": ""
},
{
"id": "5AQO",
"database": "PDB",
"url": ""
},
{
"id": "5AQN",
"database": "PDB",
"url": ""
},
{
"id": "3FZM",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP13799",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5AQS",
"database": "PDB",
"url": ""
},
{
"id": "4H5R",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5AQQ",
"database": "PDB",
"url": ""
},
{
"id": "3M3Z",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "5AQR",
"database": "PDB",
"url": ""
},
{
"id": "4H5N",
"database": "PDB",
"url": ""
},
{
"id": "4H5V",
"database": "PDB",
"url": ""
},
{
"id": "2543",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "ENSG00000109971-HSPA8",
"database": "HPA",
"url": ""
},
{
"id": "5AQU",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000432083",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000453788",
"database": "Ensembl",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "P11142",
"database": "ZINC target",
"url": ""
},
{
"id": "3FZF",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "GeneCards",
"url": ""
},
{
"id": "5AQK",
"database": "PDB",
"url": ""
},
{
"id": "3FZH",
"database": "PDB",
"url": ""
},
{
"id": "5AQJ",
"database": "PDB",
"url": ""
},
{
"id": "NP_694881.1",
"database": "RefSeq",
"url": ""
},
{
"id": "XP_011541100.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3ESK",
"database": "PDB",
"url": ""
},
{
"id": "5AQH",
"database": "PDB",
"url": ""
},
{
"id": "3AGZ",
"database": "PDB",
"url": ""
},
{
"id": "5AQI",
"database": "PDB",
"url": ""
},
{
"id": "NP_006588.1",
"database": "RefSeq",
"url": ""
},
{
"id": "6B1N",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "5AQG",
"database": "PDB",
"url": ""
},
{
"id": "3AGY",
"database": "PDB",
"url": ""
},
{
"id": "5AQF",
"database": "PDB",
"url": ""
},
{
"id": "6ZYJ",
"database": "PDB",
"url": ""
},
{
"id": "5AQV",
"database": "PDB",
"url": ""
},
{
"id": "4H5W",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000532636",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000534624",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000404372",
"database": "Ensembl",
"url": ""
},
{
"id": "6B1M",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "Ensembl",
"url": ""
},
{
"id": "4KBQ",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000437125",
"database": "Ensembl",
"url": ""
},
{
"id": "6B1I",
"database": "PDB",
"url": ""
},
{
"id": "4HWI",
"database": "PDB",
"url": ""
},
{
"id": "4H5T",
"database": "PDB",
"url": ""
},
{
"id": "5AQT",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5252048",
"participant_name": "Hikeshi [nucleoplasm]",
"crossref": [
{
"id": "3WVZ",
"database": "PDB",
"url": ""
},
{
"id": "3WW0",
"database": "PDB",
"url": ""
},
{
"id": "NP_057485.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000149196-HIKESHI",
"database": "HPA",
"url": ""
},
{
"id": "24379",
"database": "Orphanet",
"url": ""
},
{
"id": "Q53FT3",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "Q53FT3",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000278483",
"database": "Ensembl",
"url": ""
},
{
"id": "Q53FT3",
"database": "PRO",
"url": ""
},
{
"id": "Q53FT3",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000149196",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000149196",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000278483",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-53517",
"participant_name": "DHX9 [nucleoplasm]",
"crossref": [
{
"id": "3.6.4.13",
"database": "IntEnz",
"url": ""
},
{
"id": "ENST00000367549",
"database": "Ensembl",
"url": ""
},
{
"id": "Q08211",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000135829-DHX9",
"database": "HPA",
"url": ""
},
{
"id": "HMDBP11707",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000135829",
"database": "OpenTargets",
"url": ""
},
{
"id": "3VYX",
"database": "PDB",
"url": ""
},
{
"id": "Q08211",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000356520",
"database": "Ensembl",
"url": ""
},
{
"id": "Q08211",
"database": "PRO",
"url": ""
},
{
"id": "Q08211",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_001348.2",
"database": "RefSeq",
"url": ""
},
{
"id": "3VYY",
"database": "PDB",
"url": ""
},
{
"id": "3LLM",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000135829",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5688092",
"participant_name": "DHX8 [nucleoplasm]",
"crossref": [
{
"id": "6HYS",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000496923",
"database": "Ensembl",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "3I4U",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000067596",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q14562",
"database": "PRO",
"url": ""
},
{
"id": "6HYU",
"database": "PDB",
"url": ""
},
{
"id": "NP_001289552.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000067596",
"database": "Ensembl",
"url": ""
},
{
"id": "Q14562",
"database": "UniProt",
"url": ""
},
{
"id": "ENSG00000067596-DHX8",
"database": "HPA",
"url": ""
},
{
"id": "5MQF",
"database": "PDB",
"url": ""
},
{
"id": "Q14562",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENST00000262415",
"database": "Ensembl",
"url": ""
},
{
"id": "6HYT",
"database": "PDB",
"url": ""
},
{
"id": "Q14562",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_004932.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000262415",
"database": "Ensembl",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP11706",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "2EQS",
"database": "PDB",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000650571",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5688093",
"participant_name": "PRPF18 [nucleoplasm]",
"crossref": [
{
"id": "NP_003666.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000378572",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000165630-PRPF18",
"database": "HPA",
"url": ""
},
{
"id": "Q99633",
"database": "GeneCards",
"url": ""
},
{
"id": "Q99633",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000367835",
"database": "Ensembl",
"url": ""
},
{
"id": "2DK4",
"database": "PDB",
"url": ""
},
{
"id": "Q99633",
"database": "PRO",
"url": ""
},
{
"id": "Q99633",
"database": "UniProt",
"url": ""
},
{
"id": "ENSG00000165630",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000165630",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5688097",
"participant_name": "DHX15 [nucleoplasm]",
"crossref": [
{
"id": "O43143",
"database": "UniProt",
"url": ""
},
{
"id": "6SH7",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP11694",
"database": "HMDB Protein",
"url": ""
},
{
"id": "NP_001349.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000109606-DHX15",
"database": "HPA",
"url": ""
},
{
"id": "8EJM",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000336812",
"database": "Ensembl",
"url": ""
},
{
"id": "5XDR",
"database": "PDB",
"url": ""
},
{
"id": "O43143",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6ID1",
"database": "PDB",
"url": ""
},
{
"id": "O43143",
"database": "GeneCards",
"url": ""
},
{
"id": "O43143",
"database": "PRO",
"url": ""
},
{
"id": "6SH6",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109606",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000109606",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000336741",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-6814858",
"participant_name": "SRRT [nucleoplasm]",
"crossref": [
{
"id": "ENSP00000483556",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000618411",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000618262",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9BXP5",
"database": "PRO",
"url": ""
},
{
"id": "NP_001122326.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000087087-SRRT",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000087087",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000614484",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9BXP5",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENST00000611405",
"database": "Ensembl",
"url": ""
},
{
"id": "6F8D",
"database": "PDB",
"url": ""
},
{
"id": "Q9BXP5",
"database": "UniProt",
"url": ""
},
{
"id": "NP_001122325.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000480421",
"database": "Ensembl",
"url": ""
},
{
"id": "6F7P",
"database": "PDB",
"url": ""
},
{
"id": "5OO6",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000087087",
"database": "OpenTargets",
"url": ""
},
{
"id": "NP_001122324.1",
"database": "RefSeq",
"url": ""
},
{
"id": "6F7S",
"database": "PDB",
"url": ""
},
{
"id": "NP_056992.4",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000478341",
"database": "Ensembl",
"url": ""
},
{
"id": "6F7J",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000481173",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9BXP5",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-71875",
"participant_name": "TXNL4A [nucleoplasm]",
"crossref": [
{
"id": "NP_001292486.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4CDO",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000141759-TXNL4A",
"database": "HPA",
"url": ""
},
{
"id": "6AHD",
"database": "PDB",
"url": ""
},
{
"id": "1SYX",
"database": "PDB",
"url": ""
},
{
"id": "P83876",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "1QGV",
"database": "PDB",
"url": ""
},
{
"id": "5O9Z",
"database": "PDB",
"url": ""
},
{
"id": "NP_001290400.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1PQN",
"database": "PDB",
"url": ""
},
{
"id": "3JCR",
"database": "PDB",
"url": ""
},
{
"id": "23092",
"database": "Orphanet",
"url": ""
},
{
"id": "ENST00000269601",
"database": "Ensembl",
"url": ""
},
{
"id": "P83876",
"database": "UniProt",
"url": ""
},
{
"id": "6AH0",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000141759",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001292493.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4BWQ",
"database": "PDB",
"url": ""
},
{
"id": "NP_006692.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4BWS",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000141759",
"database": "OpenTargets",
"url": ""
},
{
"id": "NP_001292492.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P83876",
"database": "GeneCards",
"url": ""
},
{
"id": "P83876",
"database": "PRO",
"url": ""
},
{
"id": "6QW6",
"database": "PDB",
"url": ""
},
{
"id": "6QX9",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000269601",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-71881",
"participant_name": "PRPF6 [nucleoplasm]",
"crossref": [
{
"id": "NP_036601.2",
"database": "RefSeq",
"url": ""
},
{
"id": "3JCR",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000266079",
"database": "Ensembl",
"url": ""
},
{
"id": "5O9Z",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000266079",
"database": "Ensembl",
"url": ""
},
{
"id": "O94906",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "O94906",
"database": "GeneCards",
"url": ""
},
{
"id": "6AHD",
"database": "PDB",
"url": ""
},
{
"id": "O94906",
"database": "UniProt",
"url": ""
},
{
"id": "6AH0",
"database": "PDB",
"url": ""
},
{
"id": "6QW6",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000101161",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000101161",
"database": "OpenTargets",
"url": ""
},
{
"id": "O94906",
"database": "PRO",
"url": ""
},
{
"id": "20147",
"database": "Orphanet",
"url": ""
},
{
"id": "6QX9",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000101161-PRPF6",
"database": "HPA",
"url": ""
}
]
},
{
"participant_id": "R-HSA-71967",
"participant_name": "SF3A [nucleoplasm]",
"crossref": [
{
"id": "CPX-2565",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-71976",
"participant_name": "SF3B [nucleoplasm]",
"crossref": [
{
"id": "CPX-2227",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-72060",
"participant_name": "DHX38 [nucleoplasm]",
"crossref": [
{
"id": "Q92620",
"database": "UniProt",
"url": ""
},
{
"id": "XP_011521787.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000140829-DHX38",
"database": "HPA",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
},
{
"id": "XP_011521786.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q92620",
"database": "PRO",
"url": ""
},
{
"id": "3.6.4.13",
"database": "IntEnz",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "NP_054722.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000140829",
"database": "OpenTargets",
"url": ""
},
{
"id": "24463",
"database": "Orphanet",
"url": ""
},
{
"id": "ENSP00000268482",
"database": "Ensembl",
"url": ""
},
{
"id": "Q92620",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000140829",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000268482",
"database": "Ensembl",
"url": ""
},
{
"id": "HMDBP11901",
"database": "HMDB Protein",
"url": ""
},
{
"id": "Q92620",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-72073",
"participant_name": "hSLU7 [nucleoplasm]",
"crossref": [
{
"id": "O95391",
"database": "UniProt",
"url": ""
},
{
"id": "O95391",
"database": "PRO",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000164609",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000297151",
"database": "Ensembl",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000297151",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000164609-SLU7",
"database": "HPA",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "O95391",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_006416.3",
"database": "RefSeq",
"url": ""
},
{
"id": "XP_011532720.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000164609",
"database": "OpenTargets",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "O95391",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8849148",
"participant_name": "CASC3 [nucleoplasm]",
"crossref": [
{
"id": "O15234",
"database": "UniProt",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "2J0Q",
"database": "PDB",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000108349-CASC3",
"database": "HPA",
"url": ""
},
{
"id": "2HYI",
"database": "PDB",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "O15234",
"database": "PRO",
"url": ""
},
{
"id": "3EX7",
"database": "PDB",
"url": ""
},
{
"id": "O15234",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "2XB2",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "XP_005257220.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000264645",
"database": "Ensembl",
"url": ""
},
{
"id": "2J0U",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000108349",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_031385.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000264645",
"database": "Ensembl",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "2J0S",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000108349",
"database": "OpenTargets",
"url": ""
},
{
"id": "O15234",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8849149",
"participant_name": "EIF4A3 [nucleoplasm]",
"crossref": [
{
"id": "P38919",
"database": "UniProt",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "5MQF",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000141543",
"database": "OpenTargets",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "2HXY",
"database": "PDB",
"url": ""
},
{
"id": "2HYI",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "P38919",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "3EX7",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000141543-EIF4A3",
"database": "HPA",
"url": ""
},
{
"id": "4C9B",
"database": "PDB",
"url": ""
},
{
"id": "P38919",
"database": "GeneCards",
"url": ""
},
{
"id": "7ZNJ",
"database": "PDB",
"url": ""
},
{
"id": "2J0U",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP11795",
"database": "HMDB Protein",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "22596",
"database": "Orphanet",
"url": ""
},
{
"id": "2XB2",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000649764",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000647795",
"database": "Ensembl",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000141543",
"database": "Ensembl",
"url": ""
},
{
"id": "2J0Q",
"database": "PDB",
"url": ""
},
{
"id": "2J0S",
"database": "PDB",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "NP_055555.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P38919",
"database": "PRO",
"url": ""
},
{
"id": "6YVH",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000497641",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000497661",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8850837",
"participant_name": "DHX16 [nucleoplasm]",
"crossref": [
{
"id": "O60231",
"database": "UniProt",
"url": ""
},
{
"id": "NP_001157711.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "O60231",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000365625",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000396193",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000373071",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000204560-DHX16",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000206486",
"database": "Ensembl",
"url": ""
},
{
"id": "5Z57",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000226171",
"database": "Ensembl",
"url": ""
},
{
"id": "HMDBP10643",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000204560",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000408956",
"database": "Ensembl",
"url": ""
},
{
"id": "3.6.4.13",
"database": "IntEnz",
"url": ""
},
{
"id": "ENST00000458094",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000376442",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000417308",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000383577",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000233049",
"database": "Ensembl",
"url": ""
},
{
"id": "5Z58",
"database": "PDB",
"url": ""
},
{
"id": "O60231",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000231377",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000233418",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000451456",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000424672",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000421095",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000393958",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000390938",
"database": "Ensembl",
"url": ""
},
{
"id": "O60231",
"database": "PRO",
"url": ""
},
{
"id": "ENSP00000389862",
"database": "Ensembl",
"url": ""
},
{
"id": "5Z56",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000204560",
"database": "OpenTargets",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "NP_003578.2",
"database": "RefSeq",
"url": ""
},
{
"id": "6FF7",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000233561",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8850839",
"participant_name": "GPKOW [nucleoplasm]",
"crossref": [
{
"id": "Q92917",
"database": "UniProt",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000068394-GPKOW",
"database": "HPA",
"url": ""
},
{
"id": "Q92917",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000156109",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000156109",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000068394",
"database": "Ensembl",
"url": ""
},
{
"id": "Q92917",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000068394",
"database": "OpenTargets",
"url": ""
},
{
"id": "NP_056513.2",
"database": "RefSeq",
"url": ""
},
{
"id": "27522",
"database": "Orphanet",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "Q92917",
"database": "PRO",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8865888",
"participant_name": "SRRM2 [nucleoplasm]",
"crossref": [
{
"id": "Q9UQ35",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000167978",
"database": "Ensembl",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000167978-SRRM2",
"database": "HPA",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "5MQF",
"database": "PDB",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "5Z57",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000167978",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000301740",
"database": "Ensembl",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "6FF7",
"database": "PDB",
"url": ""
},
{
"id": "Q9UQ35",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_057417.3",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9UQ35",
"database": "UniProt",
"url": ""
},
{
"id": "6FF4",
"database": "PDB",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "5Z56",
"database": "PDB",
"url": ""
},
{
"id": "Q9UQ35",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000301740",
"database": "Ensembl",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8865956",
"participant_name": "CWC22 [nucleoplasm]",
"crossref": [
{
"id": "Q9HCG8",
"database": "UniProt",
"url": ""
},
{
"id": "Q9HCG8",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6YVH",
"database": "PDB",
"url": ""
},
{
"id": "5MQF",
"database": "PDB",
"url": ""
},
{
"id": "4C9B",
"database": "PDB",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
},
{
"id": "6FF7",
"database": "PDB",
"url": ""
},
{
"id": "Q9HCG8",
"database": "GeneCards",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "5Z57",
"database": "PDB",
"url": ""
},
{
"id": "NP_065994.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000163510",
"database": "OpenTargets",
"url": ""
},
{
"id": "5Z56",
"database": "PDB",
"url": ""
},
{
"id": "XP_005246783.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000163510-CWC22",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000163510",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000410053",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000387006",
"database": "Ensembl",
"url": ""
},
{
"id": "5Z58",
"database": "PDB",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "Q9HCG8",
"database": "PRO",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8867884",
"participant_name": "SYF2 [nucleoplasm]",
"crossref": [
{
"id": "O95926",
"database": "UniProt",
"url": ""
},
{
"id": "ENSG00000117614-SYF2",
"database": "HPA",
"url": ""
},
{
"id": "O95926",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "NP_056299.1",
"database": "RefSeq",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000117614",
"database": "OpenTargets",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "O95926",
"database": "PRO",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "5MQF",
"database": "PDB",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "6ID1",
"database": "PDB",
"url": ""
},
{
"id": "O95926",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSP00000236273",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_997053.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000117614",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000236273",
"database": "Ensembl",
"url": ""
},
{
"id": "6ID0",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000354361",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000346330",
"database": "Ensembl",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8867885",
"participant_name": "CWC27 [nucleoplasm]",
"crossref": [
{
"id": "Q6UX04",
"database": "UniProt",
"url": ""
},
{
"id": "NP_001284574.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000381070",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000153015",
"database": "Ensembl",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "NP_001284573.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q6UX04",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000370460",
"database": "Ensembl",
"url": ""
},
{
"id": "Q6UX04",
"database": "PRO",
"url": ""
},
{
"id": "5Z58",
"database": "PDB",
"url": ""
},
{
"id": "6YVH",
"database": "PDB",
"url": ""
},
{
"id": "5Z56",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000153015",
"database": "OpenTargets",
"url": ""
},
{
"id": "4R3E",
"database": "PDB",
"url": ""
},
{
"id": "6FF7",
"database": "PDB",
"url": ""
},
{
"id": "NP_005860.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000153015-CWC27",
"database": "HPA",
"url": ""
},
{
"id": "6FF4",
"database": "PDB",
"url": ""
},
{
"id": "2HQ6",
"database": "PDB",
"url": ""
},
{
"id": "Q6UX04",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8867892",
"participant_name": "PPIL1 [nucleoplasm]",
"crossref": [
{
"id": "Q9Y3C6",
"database": "UniProt",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000373699",
"database": "Ensembl",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP12808",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000137168",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9Y3C6",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5MQF",
"database": "PDB",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000362803",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_057143.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "Q9Y3C6",
"database": "GeneCards",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "7W59",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000137168-PPIL1",
"database": "HPA",
"url": ""
},
{
"id": "6ID1",
"database": "PDB",
"url": ""
},
{
"id": "2K7N",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000137168",
"database": "OpenTargets",
"url": ""
},
{
"id": "2X7K",
"database": "PDB",
"url": ""
},
{
"id": "6ID0",
"database": "PDB",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
},
{
"id": "1XWN",
"database": "PDB",
"url": ""
},
{
"id": "6FF7",
"database": "PDB",
"url": ""
},
{
"id": "Q9Y3C6",
"database": "PRO",
"url": ""
},
{
"id": "5Z56",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "5Z57",
"database": "PDB",
"url": ""
},
{
"id": "6FF4",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8867893",
"participant_name": "PPWD1 [nucleoplasm]",
"crossref": [
{
"id": "Q96BP3",
"database": "UniProt",
"url": ""
},
{
"id": "NP_056157.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q96BP3",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_001265858.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000261308",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000261308",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000113593",
"database": "Ensembl",
"url": ""
},
{
"id": "Q96BP3",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000444496",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000538977",
"database": "Ensembl",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "NP_001265856.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q96BP3",
"database": "PRO",
"url": ""
},
{
"id": "NP_001265855.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000113593-PPWD1",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000113593",
"database": "OpenTargets",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "2A2N",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8867898",
"participant_name": "CWC25 [nucleoplasm]",
"crossref": [
{
"id": "Q9NXE8",
"database": "UniProt",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "Q9NXE8",
"database": "PRO",
"url": ""
},
{
"id": "Q9NXE8",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "Q9NXE8",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000273559",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000276761",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000477799",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000478070",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000614868",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000273559",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000614790",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_060218.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000273559-CWC25",
"database": "HPA",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8869309",
"participant_name": "U2 12S snRNP [nucleoplasm]",
"crossref": [
{
"id": "CPX-2539",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8869310",
"participant_name": "TFIP11 [nucleoplasm]",
"crossref": [
{
"id": "Q9UBB9",
"database": "UniProt",
"url": ""
},
{
"id": "NP_001333787.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_036275.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001008697.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000384421",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9UBB9",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000407148",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000480171",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000383892",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000384297",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001333788.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000100109",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9UBB9",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000100109",
"database": "OpenTargets",
"url": ""
},
{
"id": "XP_011528381.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001333786.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000405938",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000619735",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000407690",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000407431",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000385861",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001333790.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9UBB9",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000100109-TFIP11",
"database": "HPA",
"url": ""
},
{
"id": "XP_016884224.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8869311",
"participant_name": "GCFC2 [nucleoplasm]",
"crossref": [
{
"id": "P16383",
"database": "UniProt",
"url": ""
},
{
"id": "P16383",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000005436",
"database": "OpenTargets",
"url": ""
},
{
"id": "HMDBP07708",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSP00000318690",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000474481",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000005436",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000541687",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000005436-GCFC2",
"database": "HPA",
"url": ""
},
{
"id": "P16383",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSP00000386552",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000437767",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000321027",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000470503",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000409857",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_003194.3",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001188264.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P16383",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_001188263.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8932217",
"participant_name": "Me3K561-HSPA8 [nucleoplasm]",
"crossref": [
{
"id": "ENSP00000432083",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000437125",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQN",
"database": "PDB",
"url": ""
},
{
"id": "6B1N",
"database": "PDB",
"url": ""
},
{
"id": "5AQM",
"database": "PDB",
"url": ""
},
{
"id": "5AQJ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "OpenTargets",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "5AQT",
"database": "PDB",
"url": ""
},
{
"id": "3FZF",
"database": "PDB",
"url": ""
},
{
"id": "4H5R",
"database": "PDB",
"url": ""
},
{
"id": "5AQF",
"database": "PDB",
"url": ""
},
{
"id": "5AQP",
"database": "PDB",
"url": ""
},
{
"id": "5AQH",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000404372",
"database": "Ensembl",
"url": ""
},
{
"id": "2543",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "5AQL",
"database": "PDB",
"url": ""
},
{
"id": "5AQK",
"database": "PDB",
"url": ""
},
{
"id": "5AQV",
"database": "PDB",
"url": ""
},
{
"id": "5AQQ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQU",
"database": "PDB",
"url": ""
},
{
"id": "24608",
"database": "Orphanet",
"url": ""
},
{
"id": "5AQI",
"database": "PDB",
"url": ""
},
{
"id": "4HWI",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "HMDBP13799",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5AQG",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "PRO",
"url": ""
},
{
"id": "XP_011541100.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000534624",
"database": "Ensembl",
"url": ""
},
{
"id": "4H5N",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "UniProt",
"url": ""
},
{
"id": "P11142",
"database": "ZINC target",
"url": ""
},
{
"id": "3AGY",
"database": "PDB",
"url": ""
},
{
"id": "5AQS",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "4H5V",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "3ESK",
"database": "PDB",
"url": ""
},
{
"id": "4KBQ",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQO",
"database": "PDB",
"url": ""
},
{
"id": "NP_006588.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3FZK",
"database": "PDB",
"url": ""
},
{
"id": "3FZH",
"database": "PDB",
"url": ""
},
{
"id": "4H5W",
"database": "PDB",
"url": ""
},
{
"id": "3M3Z",
"database": "PDB",
"url": ""
},
{
"id": "4H5T",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "GeneCards",
"url": ""
},
{
"id": "P11142",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6ZYJ",
"database": "PDB",
"url": ""
},
{
"id": "3LDQ",
"database": "PDB",
"url": ""
},
{
"id": "3AGZ",
"database": "PDB",
"url": ""
},
{
"id": "6B1M",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971-HSPA8",
"database": "HPA",
"url": ""
},
{
"id": "3FZL",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000453788",
"database": "Ensembl",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "3FZM",
"database": "PDB",
"url": ""
},
{
"id": "6B1I",
"database": "PDB",
"url": ""
},
{
"id": "NP_694881.1",
"database": "RefSeq",
"url": ""
},
{
"id": "5AQR",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000532636",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8952110",
"participant_name": "PPIL3 [nucleoplasm]",
"crossref": [
{
"id": "Q9H2H8",
"database": "UniProt",
"url": ""
},
{
"id": "XP_005246708.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9H2H8",
"database": "PRO",
"url": ""
},
{
"id": "XP_005246709.1",
"database": "RefSeq",
"url": ""
},
{
"id": "2OJU",
"database": "PDB",
"url": ""
},
{
"id": "1XYH",
"database": "PDB",
"url": ""
},
{
"id": "XP_011509660.1",
"database": "RefSeq",
"url": ""
},
{
"id": "XP_016859841.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000240344-PPIL3",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000240344",
"database": "OpenTargets",
"url": ""
},
{
"id": "NP_115861.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_570981.1",
"database": "RefSeq",
"url": ""
},
{
"id": "XP_016859844.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000376107",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000286175",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000286175",
"database": "Ensembl",
"url": ""
},
{
"id": "XP_016859845.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000392283",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H2H8",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "XP_016859842.1",
"database": "RefSeq",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000240344",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000409449",
"database": "Ensembl",
"url": ""
},
{
"id": "2OK3",
"database": "PDB",
"url": ""
},
{
"id": "XP_016859843.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000387012",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H2H8",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-8952113",
"participant_name": "PPIL4 [nucleoplasm]",
"crossref": [
{
"id": "Q8WUA2",
"database": "UniProt",
"url": ""
},
{
"id": "Q8WUA2",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "Q8WUA2",
"database": "PRO",
"url": ""
},
{
"id": "Q8WUA2",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_624311.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000253329",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000131013",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000253329",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000131013-PPIL4",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000131013",
"database": "OpenTargets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-917998",
"participant_name": "SLC32A1 [plasma membrane]",
"crossref": [
{
"id": "1133",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "ENSP00000217420",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000217420",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H598",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000101438",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H598",
"database": "PRO",
"url": ""
},
{
"id": "Q9H598",
"database": "UniProt",
"url": ""
},
{
"id": "ENSG00000101438",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000101438-SLC32A1",
"database": "HPA",
"url": ""
},
{
"id": "NP_542119.1",
"database": "RefSeq",
"url": ""
},
{
"id": "HMDBP03630",
"database": "HMDB Protein",
"url": ""
},
{
"id": "Q9H598",
"database": "GeneCards",
"url": ""
}
]
},
{
"participant_id": "R-HSA-936508",
"participant_name": "HSPA8 [plasma membrane]",
"crossref": [
{
"id": "5AQK",
"database": "PDB",
"url": ""
},
{
"id": "5AQV",
"database": "PDB",
"url": ""
},
{
"id": "5AQQ",
"database": "PDB",
"url": ""
},
{
"id": "24608",
"database": "Orphanet",
"url": ""
},
{
"id": "5AQI",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQU",
"database": "PDB",
"url": ""
},
{
"id": "4HWI",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "HMDBP13799",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5AQG",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "PRO",
"url": ""
},
{
"id": "XP_011541100.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000534624",
"database": "Ensembl",
"url": ""
},
{
"id": "4H5N",
"database": "PDB",
"url": ""
},
{
"id": "5AQL",
"database": "PDB",
"url": ""
},
{
"id": "5AQJ",
"database": "PDB",
"url": ""
},
{
"id": "5AQM",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971",
"database": "OpenTargets",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "ENSP00000437125",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000432083",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQN",
"database": "PDB",
"url": ""
},
{
"id": "6B1N",
"database": "PDB",
"url": ""
},
{
"id": "5AQT",
"database": "PDB",
"url": ""
},
{
"id": "3FZF",
"database": "PDB",
"url": ""
},
{
"id": "4H5R",
"database": "PDB",
"url": ""
},
{
"id": "5AQF",
"database": "PDB",
"url": ""
},
{
"id": "5AQP",
"database": "PDB",
"url": ""
},
{
"id": "5AQH",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000404372",
"database": "Ensembl",
"url": ""
},
{
"id": "2543",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "P11142",
"database": "UniProt",
"url": ""
},
{
"id": "P11142",
"database": "GeneCards",
"url": ""
},
{
"id": "6ZYJ",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6B1M",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000109971-HSPA8",
"database": "HPA",
"url": ""
},
{
"id": "3LDQ",
"database": "PDB",
"url": ""
},
{
"id": "3AGZ",
"database": "PDB",
"url": ""
},
{
"id": "6B1I",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000453788",
"database": "Ensembl",
"url": ""
},
{
"id": "3FZM",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "3FZL",
"database": "PDB",
"url": ""
},
{
"id": "NP_694881.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000532636",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQR",
"database": "PDB",
"url": ""
},
{
"id": "4H5T",
"database": "PDB",
"url": ""
},
{
"id": "P11142",
"database": "ZINC target",
"url": ""
},
{
"id": "5AQS",
"database": "PDB",
"url": ""
},
{
"id": "3AGY",
"database": "PDB",
"url": ""
},
{
"id": "HSP7C_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "3ESK",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "4H5V",
"database": "PDB",
"url": ""
},
{
"id": "3FZK",
"database": "PDB",
"url": ""
},
{
"id": "3FZH",
"database": "PDB",
"url": ""
},
{
"id": "4H5W",
"database": "PDB",
"url": ""
},
{
"id": "3M3Z",
"database": "PDB",
"url": ""
},
{
"id": "4KBQ",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000227378",
"database": "Ensembl",
"url": ""
},
{
"id": "5AQO",
"database": "PDB",
"url": ""
},
{
"id": "NP_006588.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-936512",
"participant_name": "DNAJC5 [plasma membrane]",
"crossref": [
{
"id": "Q9H3Z4",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_079495.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000354111",
"database": "Ensembl",
"url": ""
},
{
"id": "2N05",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000101152",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000101152-DNAJC5",
"database": "HPA",
"url": ""
},
{
"id": "Q9H3Z4",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000470551",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H3Z4",
"database": "UniProt",
"url": ""
},
{
"id": "2N04",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000101152",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000434744",
"database": "Ensembl",
"url": ""
},
{
"id": "XP_011527351.1",
"database": "RefSeq",
"url": ""
},
{
"id": "20405",
"database": "Orphanet",
"url": ""
},
{
"id": "HMDBP07651",
"database": "HMDB Protein",
"url": ""
},
{
"id": "XP_011527350.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9H3Z4",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000360864",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9626026",
"participant_name": "LAMP2a multimer complex [lysosomal lumen]",
"crossref": [
{
"id": "36080",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9626247",
"participant_name": "HSPA8:LAMP2a multimers [cytosol]",
"crossref": [
{
"id": "36080",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769561",
"participant_name": "CCDC12 [nucleoplasm]",
"crossref": [
{
"id": "Q8WUD4",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000416263",
"database": "Ensembl",
"url": ""
},
{
"id": "Q8WUD4",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000160799",
"database": "Ensembl",
"url": ""
},
{
"id": "Q8WUD4",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_001264003.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000425441",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000508011",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000160799-CCDC12",
"database": "HPA",
"url": ""
},
{
"id": "ENST00000683445",
"database": "Ensembl",
"url": ""
},
{
"id": "Q8WUD4",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000160799",
"database": "OpenTargets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769562",
"participant_name": "PPIL2 [nucleoplasm]",
"crossref": [
{
"id": "Q13356",
"database": "UniProt",
"url": ""
},
{
"id": "NP_055152.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000381812",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000679540",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000100023",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000681956",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001304925.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q13356",
"database": "PRO",
"url": ""
},
{
"id": "Q13356",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000406385",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000334553",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000398831",
"database": "Ensembl",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000505910",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000506328",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000486725",
"database": "Ensembl",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000335025",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000680061",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000506542",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000504893",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000506144",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000679795",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000384299",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000679534",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000626352",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000680393",
"database": "Ensembl",
"url": ""
},
{
"id": "7ABI",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000100023",
"database": "OpenTargets",
"url": ""
},
{
"id": "XP_011528348.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000506158",
"database": "Ensembl",
"url": ""
},
{
"id": "XP_011528349.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_680480.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q13356",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000100023-PPIL2",
"database": "HPA",
"url": ""
},
{
"id": "NP_680481.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1ZKC",
"database": "PDB",
"url": ""
},
{
"id": "XP_005261505.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769563",
"participant_name": "RNF113A [nucleoplasm]",
"crossref": [
{
"id": "O15541",
"database": "UniProt",
"url": ""
},
{
"id": "O15541",
"database": "PRO",
"url": ""
},
{
"id": "7DVQ",
"database": "PDB",
"url": ""
},
{
"id": "6FF7",
"database": "PDB",
"url": ""
},
{
"id": "2.3.2.27",
"database": "IntEnz",
"url": ""
},
{
"id": "ENSG00000125352",
"database": "OpenTargets",
"url": ""
},
{
"id": "6FF4",
"database": "PDB",
"url": ""
},
{
"id": "5Z58",
"database": "PDB",
"url": ""
},
{
"id": "NP_008909.1",
"database": "RefSeq",
"url": ""
},
{
"id": "O15541",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000125352-RNF113A",
"database": "HPA",
"url": ""
},
{
"id": "8CH6",
"database": "PDB",
"url": ""
},
{
"id": "O15541",
"database": "GeneCards",
"url": ""
},
{
"id": "5Z56",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000371442",
"database": "Ensembl",
"url": ""
},
{
"id": "7QTT",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000360497",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000125352",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769588",
"participant_name": "C9orf78 [nucleoplasm]",
"crossref": [
{
"id": "Q9NZ63",
"database": "UniProt",
"url": ""
},
{
"id": "NP_057604.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000136819",
"database": "Ensembl",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "Q9NZ63",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000361524",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000372447",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9NZ63",
"database": "PRO",
"url": ""
},
{
"id": "7OS2",
"database": "PDB",
"url": ""
},
{
"id": "Q9NZ63",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000136819-C9orf78",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000136819",
"database": "OpenTargets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769590",
"participant_name": "LENG1 [nucleoplasm]",
"crossref": [
{
"id": "Q96BZ8",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000477607",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000277457",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000481948",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000480516",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000278516",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000222224",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000483164",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000481386",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000616816",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000277808",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000610998",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000481079",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000222224",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000278426",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000481252",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000613622",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000619669",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000105617",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000614037",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000105617-LENG1",
"database": "HPA",
"url": ""
},
{
"id": "Q96BZ8",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000276774",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000276959",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000278257",
"database": "Ensembl",
"url": ""
},
{
"id": "Q96BZ8",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "Q96BZ8",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000105617",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000621285",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000479538",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000276628",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000621927",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000617592",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000275935",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000616103",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_077292.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000478485",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769591",
"participant_name": "CACTIN [nucleoplasm]",
"crossref": [
{
"id": "Q8WUQ7",
"database": "UniProt",
"url": ""
},
{
"id": "ENSG00000105298-CACTIN",
"database": "HPA",
"url": ""
},
{
"id": "Q8WUQ7",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "Q8WUQ7",
"database": "PRO",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000221899",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000105298",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000429344",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000465751",
"database": "Ensembl",
"url": ""
},
{
"id": "Q8WUQ7",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000221899",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000248420",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000248420",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_067054.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000585942",
"database": "Ensembl",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000105298",
"database": "OpenTargets",
"url": ""
},
{
"id": "NP_001074012.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000415078",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769592",
"participant_name": "PPIG [nucleoplasm]",
"crossref": [
{
"id": "Q13427",
"database": "UniProt",
"url": ""
},
{
"id": "ENST00000462903",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000435987",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000138398",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000433207",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000407083",
"database": "Ensembl",
"url": ""
},
{
"id": "Q13427",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000679107",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000678499",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000260970",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000503136",
"database": "Ensembl",
"url": ""
},
{
"id": "XP_005247024.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000448752",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000414307",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000260970",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000408683",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000676756",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000503525",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000502997",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000402222",
"database": "Ensembl",
"url": ""
},
{
"id": "Q13427",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_004783.2",
"database": "RefSeq",
"url": ""
},
{
"id": "Q13427",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "XP_005247023.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000138398",
"database": "OpenTargets",
"url": ""
},
{
"id": "2GW2",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000138398-PPIG",
"database": "HPA",
"url": ""
},
{
"id": "2WFI",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP10693",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "2WFJ",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769593",
"participant_name": "SDE2 [nucleoplasm]",
"crossref": [
{
"id": "Q6IQ49",
"database": "UniProt",
"url": ""
},
{
"id": "Q6IQ49",
"database": "PRO",
"url": ""
},
{
"id": "Q6IQ49",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000272091",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000272091",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000143751-SDE2",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000143751",
"database": "Ensembl",
"url": ""
},
{
"id": "Q6IQ49",
"database": "GeneCards",
"url": ""
},
{
"id": "7N99",
"database": "PDB",
"url": ""
},
{
"id": "NP_689821.3",
"database": "RefSeq",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000143751",
"database": "OpenTargets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769594",
"participant_name": "PRKRIP1 [nucleoplasm]",
"crossref": [
{
"id": "Q9H875",
"database": "UniProt",
"url": ""
},
{
"id": "ENST00000496391",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000381010",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_078929.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000419270",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H875",
"database": "GeneCards",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "5XJC",
"database": "PDB",
"url": ""
},
{
"id": "Q9H875",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "Q9H875",
"database": "PRO",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000128563-PRKRIP1",
"database": "HPA",
"url": ""
},
{
"id": "ENST00000397912",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000128563",
"database": "Ensembl",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000128563",
"database": "OpenTargets",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "6ICZ",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769596",
"participant_name": "STEEP1 [nucleoplasm]",
"crossref": [
{
"id": "Q9H5V9",
"database": "UniProt",
"url": ""
},
{
"id": "NP_001164041.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000320339",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000494123",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000441786",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000018610",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000018610",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q9H5V9",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_001164040.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000018610-STEEP1",
"database": "HPA",
"url": ""
},
{
"id": "Q9H5V9",
"database": "GeneCards",
"url": ""
},
{
"id": "27023",
"database": "Orphanet",
"url": ""
},
{
"id": "ENST00000644802",
"database": "Ensembl",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000536133",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9H5V9",
"database": "PRO",
"url": ""
},
{
"id": "ENSP00000320345",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_071384.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769598",
"participant_name": "FAM32A [nucleoplasm]",
"crossref": [
{
"id": "Q9Y421",
"database": "UniProt",
"url": ""
},
{
"id": "Q9Y421",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000105058-FAM32A",
"database": "HPA",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "Q9Y421",
"database": "PRO",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "Q9Y421",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000263384",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000589852",
"database": "Ensembl",
"url": ""
},
{
"id": "7W5A",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000465969",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000263384",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_054796.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000105058",
"database": "Ensembl",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000105058",
"database": "OpenTargets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769599",
"participant_name": "FAM50A [nucleoplasm]",
"crossref": [
{
"id": "Q14320",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000377225",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000071859-FAM50A",
"database": "HPA",
"url": ""
},
{
"id": "ENST00000393600",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_004690.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000071859",
"database": "Ensembl",
"url": ""
},
{
"id": "Q14320",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000071859",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q14320",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "Q14320",
"database": "PRO",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769601",
"participant_name": "DDX41 [nucleoplasm]",
"crossref": [
{
"id": "Q9UJV9",
"database": "UniProt",
"url": ""
},
{
"id": "HMDBP11674",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000183258",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000330503",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9UJV9",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000330349",
"database": "Ensembl",
"url": ""
},
{
"id": "5H1Y",
"database": "PDB",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
},
{
"id": "2P6N",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000183258",
"database": "OpenTargets",
"url": ""
},
{
"id": "5GVR",
"database": "PDB",
"url": ""
},
{
"id": "24461",
"database": "Orphanet",
"url": ""
},
{
"id": "Q9UJV9",
"database": "PRO",
"url": ""
},
{
"id": "NP_001308661.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9UJV9",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_001308759.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_057306.2",
"database": "RefSeq",
"url": ""
},
{
"id": "5GVS",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000183258-DDX41",
"database": "HPA",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9769602",
"participant_name": "NKAP [nucleoplasm]",
"crossref": [
{
"id": "Q8N5F7",
"database": "UniProt",
"url": ""
},
{
"id": "Q8N5F7",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_078804.2",
"database": "RefSeq",
"url": ""
},
{
"id": "Q8N5F7",
"database": "PRO",
"url": ""
},
{
"id": "6QDV",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000101882",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000101882-NKAP",
"database": "HPA",
"url": ""
},
{
"id": "7W5B",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000371410",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000101882",
"database": "Ensembl",
"url": ""
},
{
"id": "Q8N5F7",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSP00000360464",
"database": "Ensembl",
"url": ""
},
{
"id": "8C6J",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9770419",
"participant_name": "GPATCH1 [nucleoplasm]",
"crossref": [
{
"id": "Q9BRR8",
"database": "UniProt",
"url": ""
},
{
"id": "Q9BRR8",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_060495.2",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9BRR8",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "Q9BRR8",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000076650",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000170564",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000170564",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000076650-GPATCH1",
"database": "HPA",
"url": ""
},
{
"id": "ENSG00000076650",
"database": "OpenTargets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9770425",
"participant_name": "WDR70 [nucleoplasm]",
"crossref": [
{
"id": "Q9NW82",
"database": "UniProt",
"url": ""
},
{
"id": "Q9NW82",
"database": "GeneCards",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000082068-WDR70",
"database": "HPA",
"url": ""
},
{
"id": "ENSP00000265107",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000265107",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000082068",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_060504.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9NW82",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000082068",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q9NW82",
"database": "PRO",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9770427",
"participant_name": "DHX35 [nucleoplasm]",
"crossref": [
{
"id": "Q9H5Z1",
"database": "UniProt",
"url": ""
},
{
"id": "NP_068750.2",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001177738.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9H5Z1",
"database": "GeneCards",
"url": ""
},
{
"id": "Q9H5Z1",
"database": "PRO",
"url": ""
},
{
"id": "ENSP00000362420",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000252011",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000252011",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000373323",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000101452",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000101452",
"database": "OpenTargets",
"url": ""
},
{
"id": "HMDBP11700",
"database": "HMDB Protein",
"url": ""
},
{
"id": "Q9H5Z1",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000101452-DHX35",
"database": "HPA",
"url": ""
},
{
"id": "3.6.4.13",
"database": "IntEnz",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9770428",
"participant_name": "NSRP1 [nucleoplasm]",
"crossref": [
{
"id": "Q9H0G5",
"database": "UniProt",
"url": ""
},
{
"id": "Q9H0G5",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_115517.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000126653",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000126653-NSRP1",
"database": "HPA",
"url": ""
},
{
"id": "NP_001248396.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000247026",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000247026",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000126653",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q9H0G5",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "Q9H0G5",
"database": "PRO",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9770430",
"participant_name": "YJU2 [nucleoplasm]",
"crossref": [
{
"id": "Q9BW85",
"database": "UniProt",
"url": ""
},
{
"id": "ENST00000262962",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9BW85",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "NP_060544.2",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000105248-YJU2",
"database": "HPA",
"url": ""
},
{
"id": "6ZYM",
"database": "PDB",
"url": ""
},
{
"id": "Q9BW85",
"database": "GeneCards",
"url": ""
},
{
"id": "5YZG",
"database": "PDB",
"url": ""
},
{
"id": "7A5P",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000105248",
"database": "OpenTargets",
"url": ""
},
{
"id": "Q9BW85",
"database": "PRO",
"url": ""
},
{
"id": "ENSP00000262962",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000105248",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9770846",
"participant_name": "CWF19L2 [nucleoplasm]",
"crossref": [
{
"id": "Q2TBE0",
"database": "UniProt",
"url": ""
},
{
"id": "Q2TBE0",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000152404",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000152404",
"database": "OpenTargets",
"url": ""
},
{
"id": "6ID0",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000282251",
"database": "Ensembl",
"url": ""
},
{
"id": "Q2TBE0",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000152404-CWF19L2",
"database": "HPA",
"url": ""
},
{
"id": "NP_689647.2",
"database": "RefSeq",
"url": ""
},
{
"id": "6ID1",
"database": "PDB",
"url": ""
},
{
"id": "Q2TBE0",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSP00000282251",
"database": "Ensembl",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "A0A096MJV7",
"gene_name": "Chd9",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A096MJV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A096MJV7"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A0A096MJV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A096MJV7"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2JTM6",
"gene_name": "Dhx35",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A0G2JTM6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JTM6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A0G2JTM6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JTM6"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K0E0",
"gene_name": "Ddx56",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A0G2K0E0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K0E0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A0G2K0E0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K0E0"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K0H9",
"gene_name": "Ruvbl1-ps1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A0G2K0H9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K0H9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A0A0G2K0H9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K0H9"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K283",
"gene_name": "Dhx8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A0G2K283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K283"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A0G2K283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K283"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K4S4",
"gene_name": "Ddx51",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A0G2K4S4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K4S4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A0G2K4S4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K4S4"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2KA92",
"gene_name": "Chd2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A0G2KA92",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2KA92"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A0A0G2KA92",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2KA92"
}
]
}
]
},
{
"uniprot_ac": "A0A7N9VSG0",
"gene_name": "Afg2b",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A7N9VSG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A7N9VSG0"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "A0A7N9VSG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A7N9VSG0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZKH1",
"gene_name": "Ythdc2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I5ZKH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZKH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZKV9",
"gene_name": "Ddx5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I5ZKV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZKV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZKX7",
"gene_name": "Ddx47",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I5ZKX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKX7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZKX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKX7"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZZZ0",
"gene_name": "Ddx31",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I5ZZZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZZZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6ABZ7",
"gene_name": "Dhx9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I6ABZ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I6ABZ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AFW4",
"gene_name": "Ddx24",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I6AFW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AFW4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I6AFW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AFW4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AK63",
"gene_name": "ENSRNOG00000069014",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I6AK63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AK63"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A0A8I6AK63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AK63"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GF11",
"gene_name": "Eif4a1-ps8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I6GF11",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GF11"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A0A8I6GF11",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GF11"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GIN4",
"gene_name": "AC129365.1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I6GIN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GIN4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A0A8I6GIN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GIN4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GIY0",
"gene_name": "Chd3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A0A8I6GIY0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GIY0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A0A8I6GIY0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GIY0"
}
]
}
]
},
{
"uniprot_ac": "A1Z9L3",
"gene_name": "pea",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A1Z9L3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z9L3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A1Z9L3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z9L3"
}
]
}
]
},
{
"uniprot_ac": "A2A4P0",
"gene_name": "Dhx8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A2A4P0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2A4P0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A2A4P0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2A4P0"
}
]
}
]
},
{
"uniprot_ac": "A2A8L1",
"gene_name": "Chd5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A2A8L1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2A8L1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A2A8L1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2A8L1"
}
]
}
]
},
{
"uniprot_ac": "A2ACQ1",
"gene_name": "Dhx35",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A2ACQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2ACQ1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A2ACQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2ACQ1"
}
]
}
]
},
{
"uniprot_ac": "A2AJK6",
"gene_name": "Chd7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A2AJK6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AJK6"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A2AJK6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AJK6"
}
]
}
]
},
{
"uniprot_ac": "A2PYH4",
"gene_name": "HFM1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A2PYH4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2PYH4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A2PYH4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2PYH4"
}
]
}
]
},
{
"uniprot_ac": "A3KFM7",
"gene_name": "Chd6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A3KFM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A3KFM7"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A3KFM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A3KFM7"
}
]
}
]
},
{
"uniprot_ac": "A6KSS8",
"gene_name": "Mcm7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A6KSS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6KSS8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "A6KSS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6KSS8"
}
]
}
]
},
{
"uniprot_ac": "A6NHR9",
"gene_name": "SMCHD1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "A6NHR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6NHR9"
}
]
}
]
},
{
"uniprot_ac": "A8DZ26",
"gene_name": "anne",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "A8DZ26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A8DZ26"
}
]
}
]
},
{
"uniprot_ac": "A8MPP1",
"gene_name": "DDX11L8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "A8MPP1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A8MPP1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "A8MPP1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A8MPP1"
}
]
}
]
},
{
"uniprot_ac": "B0G0Y4",
"gene_name": "wrn",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "B0G0Y4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G0Y4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "B0G0Y4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G0Y4"
}
]
}
]
},
{
"uniprot_ac": "B1AR17",
"gene_name": "Chd3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "B1AR17",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B1AR17"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "B1AR17",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B1AR17"
}
]
}
]
},
{
"uniprot_ac": "B2GUX3",
"gene_name": "Mcm5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "B2GUX3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2GUX3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "B2GUX3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2GUX3"
}
]
}
]
},
{
"uniprot_ac": "B2RR83",
"gene_name": "Ythdc2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "B2RR83",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2RR83"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "B2RR83",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2RR83"
}
]
}
]
},
{
"uniprot_ac": "D3Z0M9",
"gene_name": "Ddx23",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3Z0M9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z0M9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3Z0M9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z0M9"
}
]
}
]
},
{
"uniprot_ac": "D3Z4R1",
"gene_name": "Hfm1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3Z4R1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z4R1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3Z4R1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z4R1"
}
]
}
]
},
{
"uniprot_ac": "D3Z9Z9",
"gene_name": "Smarcad1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3Z9Z9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z9Z9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3Z9Z9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z9Z9"
}
]
}
]
},
{
"uniprot_ac": "D3ZA12",
"gene_name": "Chd6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZA12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZA12"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZA12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZA12"
}
]
}
]
},
{
"uniprot_ac": "D3ZAP7",
"gene_name": "Chd7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZAP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZAP7"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZAP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZAP7"
}
]
}
]
},
{
"uniprot_ac": "D3ZBY5",
"gene_name": "Ddx10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZBY5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZBY5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZBY5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZBY5"
}
]
}
]
},
{
"uniprot_ac": "D3ZD32",
"gene_name": "Chd5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZD32",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD32"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZD32",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD32"
}
]
}
]
},
{
"uniprot_ac": "D3ZD46",
"gene_name": "Dhx58",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZD46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD46"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZD46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD46"
}
]
}
]
},
{
"uniprot_ac": "D3ZD97",
"gene_name": "Dhx15",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZD97",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD97"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZD97",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD97"
}
]
}
]
},
{
"uniprot_ac": "D3ZEG9",
"gene_name": "Ercc2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZEG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZEG9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZEG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZEG9"
}
]
}
]
},
{
"uniprot_ac": "D3ZFP4",
"gene_name": "Mcm3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZFP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZFP4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZFP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZFP4"
}
]
}
]
},
{
"uniprot_ac": "D3ZG52",
"gene_name": "Dna2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "D3ZG52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZG52"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZG52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZG52"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZG52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZG52"
}
]
}
]
},
{
"uniprot_ac": "D3ZH42",
"gene_name": "Mov10l1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZH42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZH42"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZH42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZH42"
}
]
}
]
},
{
"uniprot_ac": "D3ZHW0",
"gene_name": "Dhx29",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZHW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZHW0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZHW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZHW0"
}
]
}
]
},
{
"uniprot_ac": "D3ZP96",
"gene_name": "Mcm2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZP96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZP96"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZP96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZP96"
}
]
}
]
},
{
"uniprot_ac": "D3ZQW1",
"gene_name": "Blm",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZQW1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZQW1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZQW1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZQW1"
}
]
}
]
},
{
"uniprot_ac": "D3ZSV6",
"gene_name": "Dhx33",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZSV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSV6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZSV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSV6"
}
]
}
]
},
{
"uniprot_ac": "D3ZUC2",
"gene_name": "Mov10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZUC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZUC2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZUC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZUC2"
}
]
}
]
},
{
"uniprot_ac": "D3ZVK1",
"gene_name": "Mcm8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZVK1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZVK1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D3ZVK1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZVK1"
}
]
}
]
},
{
"uniprot_ac": "D3ZX56",
"gene_name": "Ddx55",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D3ZX56",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZX56"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D3ZX56",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZX56"
}
]
}
]
},
{
"uniprot_ac": "D4A1R0",
"gene_name": "Dhx37",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4A1R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A1R0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D4A1R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A1R0"
}
]
}
]
},
{
"uniprot_ac": "D4A2B7",
"gene_name": "Afg2b",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4A2B7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A2B7"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "D4A2B7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A2B7"
}
]
}
]
},
{
"uniprot_ac": "D4A2Z8",
"gene_name": "Dhx36",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4A2Z8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A2Z8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4A2Z8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A2Z8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D4A2Z8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A2Z8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D4A2Z8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A2Z8"
}
]
}
]
},
{
"uniprot_ac": "D4A321",
"gene_name": "Dhx38",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4A321",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A321"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D4A321",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A321"
}
]
}
]
},
{
"uniprot_ac": "D4A523",
"gene_name": "Nlrp3",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "D4A523",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A523"
}
]
}
]
},
{
"uniprot_ac": "D4A6Q6",
"gene_name": "Ino80",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "D4A6Q6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A6Q6"
}
]
}
]
},
{
"uniprot_ac": "D4A7Q5",
"gene_name": "Ddx28",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4A7Q5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A7Q5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D4A7Q5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A7Q5"
}
]
}
]
},
{
"uniprot_ac": "D4AAG9",
"gene_name": "Chd1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4AAG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AAG9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D4AAG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AAG9"
}
]
}
]
},
{
"uniprot_ac": "D4ACP5",
"gene_name": "Recql5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4ACP5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4ACP5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "D4ACP5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4ACP5"
}
]
}
]
},
{
"uniprot_ac": "D4ADT5",
"gene_name": "Rig1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "D4ADT5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4ADT5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "D4ADT5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4ADT5"
}
]
}
]
},
{
"uniprot_ac": "E9PU01",
"gene_name": "Chd4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "E9PU01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PU01"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "E9PU01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PU01"
}
]
}
]
},
{
"uniprot_ac": "E9PZJ8",
"gene_name": "Ascc3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "E9PZJ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PZJ8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "E9PZJ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PZJ8"
}
]
}
]
},
{
"uniprot_ac": "E9PZM4",
"gene_name": "Chd2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "E9PZM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PZM4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "E9PZM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PZM4"
}
]
}
]
},
{
"uniprot_ac": "E9Q555",
"gene_name": "Rnf213",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "E9Q555",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q555"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "E9Q555",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q555"
}
]
},
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "E9Q555",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q555"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "E9Q555",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q555"
}
]
}
]
},
{
"uniprot_ac": "E9QAM5",
"gene_name": "Helz2",
"activity": [
{
"ec_number": "3.1.13.1",
"activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.",
"evidence": [
{
"id": "E9QAM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9QAM5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "E9QAM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9QAM5"
}
]
},
{
"ec_number": "3.1.13.1",
"activity": "",
"evidence": [
{
"id": "E9QAM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9QAM5"
}
]
}
]
},
{
"uniprot_ac": "F1LNJ2",
"gene_name": "Snrnp200",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "F1LNJ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LNJ2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "F1LNJ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LNJ2"
}
]
}
]
},
{
"uniprot_ac": "F1LPQ2",
"gene_name": "Ascc3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "F1LPQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LPQ2"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "F1LPQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LPQ2"
}
]
}
]
},
{
"uniprot_ac": "F1LTH9",
"gene_name": "Wrn",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "F1LTH9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LTH9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "F1LTH9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LTH9"
}
]
}
]
},
{
"uniprot_ac": "F1LTR3",
"gene_name": "Tdrd12",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "F1LTR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LTR3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "F1LTR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LTR3"
}
]
}
]
},
{
"uniprot_ac": "F1LWY1",
"gene_name": "Hfm1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "F1LWY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LWY1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "F1LWY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LWY1"
}
]
}
]
},
{
"uniprot_ac": "F1M298",
"gene_name": "Fbh1",
"activity": [
{
"ec_number": "5.6.2.4",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.",
"evidence": [
{
"id": "F1M298",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M298"
}
]
},
{
"ec_number": "5.6.2.4",
"activity": "",
"evidence": [
{
"id": "F1M298",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M298"
}
]
}
]
},
{
"uniprot_ac": "F1M5F3",
"gene_name": "Mcm9",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "F1M5F3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M5F3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "F1M5F3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M5F3"
}
]
}
]
},
{
"uniprot_ac": "F1M9L4",
"gene_name": "Atp13a4",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "F1M9L4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M9L4"
}
]
}
]
},
{
"uniprot_ac": "F1MA70",
"gene_name": "Atp13a5",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "F1MA70",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1MA70"
}
]
}
]
},
{
"uniprot_ac": "F8VPZ5",
"gene_name": "Ercc6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "F8VPZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F8VPZ5"
}
]
}
]
},
{
"uniprot_ac": "G3V681",
"gene_name": "Mcm4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "G3V681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V681"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "G3V681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V681"
}
]
}
]
},
{
"uniprot_ac": "G3V6W5",
"gene_name": "Ifih1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "G3V6W5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V6W5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "G3V6W5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V6W5"
}
]
}
]
},
{
"uniprot_ac": "G3V8T5",
"gene_name": "Ruvbl2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "G3V8T5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V8T5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "G3V8T5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V8T5"
}
]
}
]
},
{
"uniprot_ac": "G3V9M1",
"gene_name": "Ddx23",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "G3V9M1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V9M1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "G3V9M1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V9M1"
}
]
}
]
},
{
"uniprot_ac": "G3X8X0",
"gene_name": "Dhx16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "G3X8X0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3X8X0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "G3X8X0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3X8X0"
}
]
}
]
},
{
"uniprot_ac": "O00115",
"gene_name": "DNASE2",
"activity": [
{
"ec_number": "3.1.22.1",
"activity": "Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.",
"evidence": [
{
"id": "O00115",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00115"
}
]
},
{
"ec_number": "3.1.22.1",
"activity": "",
"evidence": [
{
"id": "O00115",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00115"
}
]
}
]
},
{
"uniprot_ac": "O00148",
"gene_name": "DDX39A",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O00148",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00148"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O00148",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00148"
}
]
}
]
},
{
"uniprot_ac": "O00443",
"gene_name": "PIK3C2A",
"activity": [
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
}
]
},
{
"uniprot_ac": "O00487",
"gene_name": "PSMD14",
"activity": [
{
"ec_number": "3.4.19.-",
"activity": "",
"evidence": [
{
"id": "O00487",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00487"
}
]
}
]
},
{
"uniprot_ac": "O00571",
"gene_name": "DDX3X",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O00571",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00571"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O00571",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00571"
}
]
}
]
},
{
"uniprot_ac": "O00764",
"gene_name": "PDXK",
"activity": [
{
"ec_number": "2.7.1.35",
"activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.",
"evidence": [
{
"id": "O00764",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00764"
}
]
},
{
"ec_number": "2.7.1.35",
"activity": "",
"evidence": [
{
"id": "O00764",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00764"
}
]
}
]
},
{
"uniprot_ac": "O00835",
"gene_name": "repB",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O00835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00835"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O00835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00835"
}
]
}
]
},
{
"uniprot_ac": "O08811",
"gene_name": "Ercc2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O08811",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08811"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O08811",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08811"
}
]
}
]
},
{
"uniprot_ac": "O09053",
"gene_name": "Wrn",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O09053",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09053"
}
]
},
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "O09053",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09053"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O09053",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09053"
}
]
}
]
},
{
"uniprot_ac": "O13559",
"gene_name": "YRF1-4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O13559",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13559"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O13559",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13559"
}
]
}
]
},
{
"uniprot_ac": "O14646",
"gene_name": "CHD1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O14646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14646"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O14646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14646"
}
]
}
]
},
{
"uniprot_ac": "O14647",
"gene_name": "CHD2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O14647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14647"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O14647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14647"
}
]
}
]
},
{
"uniprot_ac": "O14656",
"gene_name": "TOR1A",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "O14656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14656"
}
]
}
]
},
{
"uniprot_ac": "O14657",
"gene_name": "TOR1B",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "O14657",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14657"
}
]
}
]
},
{
"uniprot_ac": "O14976",
"gene_name": "GAK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14976"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14976"
}
]
}
]
},
{
"uniprot_ac": "O15056",
"gene_name": "SYNJ2",
"activity": [
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "O15056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15056"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "O15056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15056"
}
]
},
{
"ec_number": "3.1.3.64",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.",
"evidence": [
{
"id": "O15056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15056"
}
]
},
{
"ec_number": "3.1.3.64",
"activity": "",
"evidence": [
{
"id": "O15056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15056"
}
]
}
]
},
{
"uniprot_ac": "O15523",
"gene_name": "DDX3Y",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O15523",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15523"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O15523",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15523"
}
]
}
]
},
{
"uniprot_ac": "O15541",
"gene_name": "RNF113A",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O15541",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15541"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O15541",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15541"
}
]
}
]
},
{
"uniprot_ac": "O16102",
"gene_name": "Chd3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O16102",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O16102"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O16102",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O16102"
}
]
}
]
},
{
"uniprot_ac": "O35286",
"gene_name": "Dhx15",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O35286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35286"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O35286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35286"
}
]
}
]
},
{
"uniprot_ac": "O43143",
"gene_name": "DHX15",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O43143",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43143"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O43143",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43143"
}
]
}
]
},
{
"uniprot_ac": "O43426",
"gene_name": "SYNJ1",
"activity": [
{
"ec_number": "3.1.3.64",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
},
{
"ec_number": "3.1.3.64",
"activity": "",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
}
]
},
{
"uniprot_ac": "O43447",
"gene_name": "PPIH",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "O43447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43447"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "O43447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43447"
}
]
}
]
},
{
"uniprot_ac": "O43933",
"gene_name": "PEX1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "O43933",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43933"
}
]
}
]
},
{
"uniprot_ac": "O46072",
"gene_name": "kz",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O46072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O46072"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O46072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O46072"
}
]
}
]
},
{
"uniprot_ac": "O60231",
"gene_name": "DHX16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O60231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60231"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O60231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60231"
}
]
}
]
},
{
"uniprot_ac": "O60282",
"gene_name": "KIF5C",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "O60282",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60282"
}
]
}
]
},
{
"uniprot_ac": "O60306",
"gene_name": "AQR",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O60306",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60306"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O60306",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60306"
}
]
}
]
},
{
"uniprot_ac": "O61305",
"gene_name": "Dbp80",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O61305",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61305"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O61305",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61305"
}
]
}
]
},
{
"uniprot_ac": "O70133",
"gene_name": "Dhx9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O70133",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70133"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O70133",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70133"
}
]
}
]
},
{
"uniprot_ac": "O75061",
"gene_name": "DNAJC6",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O75061",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75061"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O75061",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75061"
}
]
}
]
},
{
"uniprot_ac": "O75351",
"gene_name": "VPS4B",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O75351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75351"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "O75351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75351"
}
]
}
]
},
{
"uniprot_ac": "O75417",
"gene_name": "POLQ",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O75417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75417"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O75417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75417"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O75417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75417"
}
]
}
]
},
{
"uniprot_ac": "O75643",
"gene_name": "SNRNP200",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O75643",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75643"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O75643",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75643"
}
]
}
]
},
{
"uniprot_ac": "O75874",
"gene_name": "IDH1",
"activity": [
{
"ec_number": "1.1.1.42",
"activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.",
"evidence": [
{
"id": "O75874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75874"
}
]
},
{
"ec_number": "1.1.1.42",
"activity": "",
"evidence": [
{
"id": "O75874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75874"
}
]
}
]
},
{
"uniprot_ac": "O75976",
"gene_name": "CPD",
"activity": [
{
"ec_number": "3.4.17.22",
"activity": "Releases C-terminal Arg and Lys from polypeptides.",
"evidence": [
{
"id": "O75976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75976"
}
]
},
{
"ec_number": "3.4.17.22",
"activity": "",
"evidence": [
{
"id": "O75976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75976"
}
]
}
]
},
{
"uniprot_ac": "O88700",
"gene_name": "Blm",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O88700",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88700"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O88700",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88700"
}
]
}
]
},
{
"uniprot_ac": "O94761",
"gene_name": "RECQL4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O94761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94761"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O94761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94761"
}
]
}
]
},
{
"uniprot_ac": "O94762",
"gene_name": "RECQL5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O94762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94762"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O94762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94762"
}
]
}
]
},
{
"uniprot_ac": "O95786",
"gene_name": "RIGI",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O95786",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95786"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "O95786",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95786"
}
]
}
]
},
{
"uniprot_ac": "O97159",
"gene_name": "Mi-2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O97159",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O97159"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "O97159",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O97159"
}
]
}
]
},
{
"uniprot_ac": "P00491",
"gene_name": "PNP",
"activity": [
{
"ec_number": "2.4.2.1",
"activity": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase.",
"evidence": [
{
"id": "P00491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00491"
}
]
},
{
"ec_number": "2.4.2.1",
"activity": "",
"evidence": [
{
"id": "P00491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00491"
}
]
}
]
},
{
"uniprot_ac": "P00533",
"gene_name": "EGFR",
"activity": [
{
"ec_number": "2.7.10.1",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P00533",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00533"
}
]
},
{
"ec_number": "2.7.10.1",
"activity": "",
"evidence": [
{
"id": "P00533",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00533"
}
]
}
]
},
{
"uniprot_ac": "P00746",
"gene_name": "CFD",
"activity": [
{
"ec_number": "3.4.21.46",
"activity": "Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.",
"evidence": [
{
"id": "P00746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00746"
}
]
},
{
"ec_number": "3.4.21.46",
"activity": "",
"evidence": [
{
"id": "P00746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00746"
}
]
}
]
},
{
"uniprot_ac": "P02572",
"gene_name": "Act42A",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P02572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02572"
}
]
}
]
},
{
"uniprot_ac": "P02574",
"gene_name": "Act79B",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P02574",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02574"
}
]
}
]
},
{
"uniprot_ac": "P02794",
"gene_name": "FTH1",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P02794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02794"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P02794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02794"
}
]
}
]
},
{
"uniprot_ac": "P04040",
"gene_name": "CAT",
"activity": [
{
"ec_number": "1.11.1.6",
"activity": "2 H2O2 = 2 H2O + O2.",
"evidence": [
{
"id": "P04040",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04040"
}
]
},
{
"ec_number": "1.11.1.6",
"activity": "",
"evidence": [
{
"id": "P04040",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04040"
}
]
}
]
},
{
"uniprot_ac": "P04075",
"gene_name": "ALDOA",
"activity": [
{
"ec_number": "4.1.2.13",
"activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.",
"evidence": [
{
"id": "P04075",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04075"
}
]
},
{
"ec_number": "4.1.2.13",
"activity": "",
"evidence": [
{
"id": "P04075",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04075"
}
]
}
]
},
{
"uniprot_ac": "P05186",
"gene_name": "ALPL",
"activity": [
{
"ec_number": "3.1.3.1",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "P05186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05186"
}
]
},
{
"ec_number": "3.9.1.1",
"activity": "H2O + N-phosphocreatine = creatine + phosphate.",
"evidence": [
{
"id": "P05186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05186"
}
]
},
{
"ec_number": "3.1.3.1",
"activity": "",
"evidence": [
{
"id": "P05186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05186"
}
]
},
{
"ec_number": "3.9.1.1",
"activity": "",
"evidence": [
{
"id": "P05186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05186"
}
]
}
]
},
{
"uniprot_ac": "P06634",
"gene_name": "DED1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P06634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06634"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P06634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06634"
}
]
}
]
},
{
"uniprot_ac": "P06737",
"gene_name": "PYGL",
"activity": [
{
"ec_number": "2.4.1.1",
"activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.",
"evidence": [
{
"id": "P06737",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06737"
}
]
},
{
"ec_number": "2.4.1.1",
"activity": "",
"evidence": [
{
"id": "P06737",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06737"
}
]
}
]
},
{
"uniprot_ac": "P06744",
"gene_name": "GPI",
"activity": [
{
"ec_number": "5.3.1.9",
"activity": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate.",
"evidence": [
{
"id": "P06744",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06744"
}
]
},
{
"ec_number": "5.3.1.9",
"activity": "",
"evidence": [
{
"id": "P06744",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06744"
}
]
}
]
},
{
"uniprot_ac": "P06761",
"gene_name": "Hspa5",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P06761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06761"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P06761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06761"
}
]
}
]
},
{
"uniprot_ac": "P06839",
"gene_name": "RAD3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P06839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06839"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P06839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06839"
}
]
}
]
},
{
"uniprot_ac": "P07271",
"gene_name": "PIF1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P07271",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07271"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P07271",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07271"
}
]
}
]
},
{
"uniprot_ac": "P07339",
"gene_name": "CTSD",
"activity": [
{
"ec_number": "3.4.23.5",
"activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.",
"evidence": [
{
"id": "P07339",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07339"
}
]
},
{
"ec_number": "3.4.23.5",
"activity": "",
"evidence": [
{
"id": "P07339",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07339"
}
]
}
]
},
{
"uniprot_ac": "P07384",
"gene_name": "CAPN1",
"activity": [
{
"ec_number": "3.4.22.52",
"activity": "Broad endopeptidase specificity.",
"evidence": [
{
"id": "P07384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07384"
}
]
},
{
"ec_number": "3.4.22.52",
"activity": "",
"evidence": [
{
"id": "P07384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07384"
}
]
}
]
},
{
"uniprot_ac": "P07741",
"gene_name": "APRT",
"activity": [
{
"ec_number": "2.4.2.7",
"activity": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine.",
"evidence": [
{
"id": "P07741",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07741"
}
]
},
{
"ec_number": "2.4.2.7",
"activity": "",
"evidence": [
{
"id": "P07741",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07741"
}
]
}
]
},
{
"uniprot_ac": "P07828",
"gene_name": "act18",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P07828",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07828"
}
]
}
]
},
{
"uniprot_ac": "P07829",
"gene_name": "act3",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P07829",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07829"
}
]
}
]
},
{
"uniprot_ac": "P07830",
"gene_name": "act19",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P07830",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07830"
}
]
}
]
},
{
"uniprot_ac": "P07858",
"gene_name": "CTSB",
"activity": [
{
"ec_number": "3.4.22.1",
"activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.",
"evidence": [
{
"id": "P07858",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07858"
}
]
},
{
"ec_number": "3.4.22.1",
"activity": "",
"evidence": [
{
"id": "P07858",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07858"
}
]
}
]
},
{
"uniprot_ac": "P07900",
"gene_name": "HSP90AA1",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P07900",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07900"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P07900",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07900"
}
]
}
]
},
{
"uniprot_ac": "P07901",
"gene_name": "Hsp90aa1",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P07901",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07901"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P07901",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07901"
}
]
}
]
},
{
"uniprot_ac": "P07998",
"gene_name": "RNASE1",
"activity": [
{
"ec_number": "4.6.1.18",
"activity": "an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].",
"evidence": [
{
"id": "P07998",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07998"
}
]
},
{
"ec_number": "4.6.1.18",
"activity": "",
"evidence": [
{
"id": "P07998",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07998"
}
]
}
]
},
{
"uniprot_ac": "P08236",
"gene_name": "GUSB",
"activity": [
{
"ec_number": "3.2.1.31",
"activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.",
"evidence": [
{
"id": "P08236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08236"
}
]
},
{
"ec_number": "3.2.1.31",
"activity": "",
"evidence": [
{
"id": "P08236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08236"
}
]
}
]
},
{
"uniprot_ac": "P08289",
"gene_name": "Alpl",
"activity": [
{
"ec_number": "3.1.3.1",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "P08289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08289"
}
]
},
{
"ec_number": "3.9.1.1",
"activity": "H2O + N-phosphocreatine = creatine + phosphate.",
"evidence": [
{
"id": "P08289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08289"
}
]
},
{
"ec_number": "3.1.3.1",
"activity": "",
"evidence": [
{
"id": "P08289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08289"
}
]
}
]
},
{
"uniprot_ac": "P09052",
"gene_name": "vas",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P09052",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09052"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P09052",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09052"
}
]
}
]
},
{
"uniprot_ac": "P09211",
"gene_name": "GSTP1",
"activity": [
{
"ec_number": "2.5.1.18",
"activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).",
"evidence": [
{
"id": "P09211",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09211"
}
]
},
{
"ec_number": "2.5.1.18",
"activity": "",
"evidence": [
{
"id": "P09211",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09211"
}
]
}
]
},
{
"uniprot_ac": "P09242",
"gene_name": "Alpl",
"activity": [
{
"ec_number": "3.1.3.1",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "P09242",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09242"
}
]
},
{
"ec_number": "3.9.1.1",
"activity": "H2O + N-phosphocreatine = creatine + phosphate.",
"evidence": [
{
"id": "P09242",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09242"
}
]
},
{
"ec_number": "3.1.3.1",
"activity": "",
"evidence": [
{
"id": "P09242",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09242"
}
]
},
{
"ec_number": "3.9.1.1",
"activity": "",
"evidence": [
{
"id": "P09242",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09242"
}
]
}
]
},
{
"uniprot_ac": "P09769",
"gene_name": "FGR",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P09769",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09769"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P09769",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09769"
}
]
}
]
},
{
"uniprot_ac": "P09917",
"gene_name": "ALOX5",
"activity": [
{
"ec_number": "1.13.11.-",
"activity": "",
"evidence": [
{
"id": "P09917",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09917"
}
]
},
{
"ec_number": "1.13.11.34",
"activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4.",
"evidence": [
{
"id": "P09917",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09917"
}
]
}
]
},
{
"uniprot_ac": "P09960",
"gene_name": "LTA4H",
"activity": [
{
"ec_number": "3.3.2.6",
"activity": "H2O + leukotriene A4 = leukotriene B4.",
"evidence": [
{
"id": "P09960",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09960"
}
]
},
{
"ec_number": "3.4.11.4",
"activity": "Release of the N-terminal residue from a tripeptide.",
"evidence": [
{
"id": "P09960",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09960"
}
]
},
{
"ec_number": "3.3.2.6",
"activity": "",
"evidence": [
{
"id": "P09960",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09960"
}
]
}
]
},
{
"uniprot_ac": "P09972",
"gene_name": "ALDOC",
"activity": [
{
"ec_number": "4.1.2.13",
"activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.",
"evidence": [
{
"id": "P09972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09972"
}
]
},
{
"ec_number": "4.1.2.13",
"activity": "",
"evidence": [
{
"id": "P09972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09972"
}
]
}
]
},
{
"uniprot_ac": "P0CS90",
"gene_name": "SSC1",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P0CS90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CS90"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P0CS90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CS90"
}
]
}
]
},
{
"uniprot_ac": "P0CX14",
"gene_name": "YRF1-3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P0CX14",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX14"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P0CX14",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX14"
}
]
}
]
},
{
"uniprot_ac": "P0CX15",
"gene_name": "YRF1-7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P0CX15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX15"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P0CX15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX15"
}
]
}
]
},
{
"uniprot_ac": "P0CX20",
"gene_name": "YRF1-1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P0CX20",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX20"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P0CX20",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX20"
}
]
}
]
},
{
"uniprot_ac": "P0CX21",
"gene_name": "YRF1-5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P0CX21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX21"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P0CX21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX21"
}
]
}
]
},
{
"uniprot_ac": "P0CX22",
"gene_name": "YRF1-8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P0CX22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX22"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P0CX22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX22"
}
]
}
]
},
{
"uniprot_ac": "P10081",
"gene_name": "TIF1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P10081",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10081"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P10081",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10081"
}
]
}
]
},
{
"uniprot_ac": "P10630",
"gene_name": "Eif4a2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P10630",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10630"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P10630",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10630"
}
]
}
]
},
{
"uniprot_ac": "P10981",
"gene_name": "Act87E",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P10981",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10981"
}
]
}
]
},
{
"uniprot_ac": "P10987",
"gene_name": "Act5C",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P10987",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10987"
}
]
}
]
},
{
"uniprot_ac": "P11021",
"gene_name": "HSPA5",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P11021",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11021"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P11021",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11021"
}
]
}
]
},
{
"uniprot_ac": "P11142",
"gene_name": "HSPA8",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P11142",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11142"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P11142",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11142"
}
]
}
]
},
{
"uniprot_ac": "P11484",
"gene_name": "SSB1",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P11484",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11484"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P11484",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11484"
}
]
}
]
},
{
"uniprot_ac": "P11678",
"gene_name": "EPX",
"activity": [
{
"ec_number": "1.11.1.7",
"activity": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O.",
"evidence": [
{
"id": "P11678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11678"
}
]
},
{
"ec_number": "1.11.1.7",
"activity": "",
"evidence": [
{
"id": "P11678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11678"
}
]
}
]
},
{
"uniprot_ac": "P12268",
"gene_name": "IMPDH2",
"activity": [
{
"ec_number": "1.1.1.205",
"activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.",
"evidence": [
{
"id": "P12268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12268"
}
]
},
{
"ec_number": "1.1.1.205",
"activity": "",
"evidence": [
{
"id": "P12268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12268"
}
]
}
]
},
{
"uniprot_ac": "P12954",
"gene_name": "SRS2",
"activity": [
{
"ec_number": "5.6.2.4",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.",
"evidence": [
{
"id": "P12954",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12954"
}
]
},
{
"ec_number": "5.6.2.4",
"activity": "",
"evidence": [
{
"id": "P12954",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12954"
}
]
}
]
},
{
"uniprot_ac": "P12956",
"gene_name": "XRCC6",
"activity": [
{
"ec_number": "4.2.99.-",
"activity": "",
"evidence": [
{
"id": "P12956",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12956"
}
]
},
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P12956",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12956"
}
]
}
]
},
{
"uniprot_ac": "P13010",
"gene_name": "XRCC5",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P13010",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13010"
}
]
}
]
},
{
"uniprot_ac": "P13569",
"gene_name": "CFTR",
"activity": [
{
"ec_number": "5.6.1.6",
"activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.",
"evidence": [
{
"id": "P13569",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13569"
}
]
},
{
"ec_number": "5.6.1.6",
"activity": "",
"evidence": [
{
"id": "P13569",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13569"
}
]
}
]
},
{
"uniprot_ac": "P13639",
"gene_name": "EEF2",
"activity": [
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "P13639",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13639"
}
]
}
]
},
{
"uniprot_ac": "P13716",
"gene_name": "ALAD",
"activity": [
{
"ec_number": "4.2.1.24",
"activity": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen.",
"evidence": [
{
"id": "P13716",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13716"
}
]
},
{
"ec_number": "4.2.1.24",
"activity": "",
"evidence": [
{
"id": "P13716",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13716"
}
]
}
]
},
{
"uniprot_ac": "P13798",
"gene_name": "APEH",
"activity": [
{
"ec_number": "3.4.19.1",
"activity": "Internal cleavage of oxidized and glycated proteins.",
"evidence": [
{
"id": "P13798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13798"
}
]
},
{
"ec_number": "3.4.19.1",
"activity": "",
"evidence": [
{
"id": "P13798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13798"
}
]
}
]
},
{
"uniprot_ac": "P14174",
"gene_name": "MIF",
"activity": [
{
"ec_number": "5.3.2.1",
"activity": "3-phenylpyruvate = enol-phenylpyruvate.",
"evidence": [
{
"id": "P14174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14174"
}
]
},
{
"ec_number": "5.3.3.12",
"activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.",
"evidence": [
{
"id": "P14174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14174"
}
]
},
{
"ec_number": "5.3.2.1",
"activity": "",
"evidence": [
{
"id": "P14174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14174"
}
]
}
]
},
{
"uniprot_ac": "P14618",
"gene_name": "PKM",
"activity": [
{
"ec_number": "2.7.1.40",
"activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
},
{
"ec_number": "2.7.1.40",
"activity": "",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
}
]
},
{
"uniprot_ac": "P14780",
"gene_name": "MMP9",
"activity": [
{
"ec_number": "3.4.24.35",
"activity": "Cleavage of gelatin types I and V and collagen types IV and V.",
"evidence": [
{
"id": "P14780",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14780"
}
]
},
{
"ec_number": "3.4.24.35",
"activity": "",
"evidence": [
{
"id": "P14780",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14780"
}
]
}
]
},
{
"uniprot_ac": "P15424",
"gene_name": "MSS116",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P15424",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15424"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P15424",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15424"
}
]
}
]
},
{
"uniprot_ac": "P15586",
"gene_name": "GNS",
"activity": [
{
"ec_number": "3.1.6.14",
"activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.",
"evidence": [
{
"id": "P15586",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15586"
}
]
},
{
"ec_number": "3.1.6.14",
"activity": "",
"evidence": [
{
"id": "P15586",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15586"
}
]
}
]
},
{
"uniprot_ac": "P15848",
"gene_name": "ARSB",
"activity": [
{
"ec_number": "3.1.6.12",
"activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.",
"evidence": [
{
"id": "P15848",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15848"
}
]
},
{
"ec_number": "3.1.6.12",
"activity": "",
"evidence": [
{
"id": "P15848",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15848"
}
]
}
]
},
{
"uniprot_ac": "P15938",
"gene_name": "PRP16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P15938",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15938"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P15938",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15938"
}
]
}
]
},
{
"uniprot_ac": "P16050",
"gene_name": "ALOX15",
"activity": [
{
"ec_number": "1.13.11.-",
"activity": "",
"evidence": [
{
"id": "P16050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16050"
}
]
},
{
"ec_number": "1.13.11.31",
"activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.",
"evidence": [
{
"id": "P16050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16050"
}
]
},
{
"ec_number": "1.13.11.33",
"activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.",
"evidence": [
{
"id": "P16050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16050"
}
]
},
{
"ec_number": "1.13.11.12",
"activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.",
"evidence": [
{
"id": "P16050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16050"
}
]
}
]
},
{
"uniprot_ac": "P16278",
"gene_name": "GLB1",
"activity": [
{
"ec_number": "3.2.1.23",
"activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.",
"evidence": [
{
"id": "P16278",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16278"
}
]
},
{
"ec_number": "3.2.1.23",
"activity": "",
"evidence": [
{
"id": "P16278",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16278"
}
]
}
]
},
{
"uniprot_ac": "P16381",
"gene_name": "D1Pas1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P16381",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16381"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P16381",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16381"
}
]
}
]
},
{
"uniprot_ac": "P16474",
"gene_name": "KAR2",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P16474",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16474"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P16474",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16474"
}
]
}
]
},
{
"uniprot_ac": "P16521",
"gene_name": "YEF3",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P16521",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16521"
}
]
}
]
},
{
"uniprot_ac": "P17119",
"gene_name": "KAR3",
"activity": [
{
"ec_number": "5.6.1.4",
"activity": "ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate + a kinesin associated with a microtubule at position (n-1, toward the minus end).",
"evidence": [
{
"id": "P17119",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17119"
}
]
},
{
"ec_number": "5.6.1.4",
"activity": "",
"evidence": [
{
"id": "P17119",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17119"
}
]
}
]
},
{
"uniprot_ac": "P17844",
"gene_name": "DDX5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P17844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17844"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P17844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17844"
}
]
}
]
},
{
"uniprot_ac": "P17858",
"gene_name": "PFKL",
"activity": [
{
"ec_number": "2.7.1.11",
"activity": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+).",
"evidence": [
{
"id": "P17858",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17858"
}
]
},
{
"ec_number": "2.7.1.11",
"activity": "",
"evidence": [
{
"id": "P17858",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17858"
}
]
}
]
},
{
"uniprot_ac": "P18074",
"gene_name": "ERCC2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P18074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18074"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P18074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18074"
}
]
}
]
},
{
"uniprot_ac": "P18669",
"gene_name": "PGAM1",
"activity": [
{
"ec_number": "5.4.2.11",
"activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.",
"evidence": [
{
"id": "P18669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18669"
}
]
},
{
"ec_number": "5.4.2.4",
"activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).",
"evidence": [
{
"id": "P18669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18669"
}
]
},
{
"ec_number": "5.4.2.4",
"activity": "",
"evidence": [
{
"id": "P18669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18669"
}
]
},
{
"ec_number": "5.4.2.11",
"activity": "",
"evidence": [
{
"id": "P18669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18669"
}
]
}
]
},
{
"uniprot_ac": "P19109",
"gene_name": "Rm62",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P19109",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19109"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P19109",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19109"
}
]
}
]
},
{
"uniprot_ac": "P19447",
"gene_name": "ERCC3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P19447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19447"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P19447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19447"
}
]
}
]
},
{
"uniprot_ac": "P19525",
"gene_name": "EIF2AK2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P19525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19525"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P19525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19525"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P19525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19525"
}
]
}
]
},
{
"uniprot_ac": "P20029",
"gene_name": "Hspa5",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P20029",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20029"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P20029",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20029"
}
]
}
]
},
{
"uniprot_ac": "P20095",
"gene_name": "PRP2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P20095",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20095"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P20095",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20095"
}
]
}
]
},
{
"uniprot_ac": "P20447",
"gene_name": "DBP3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P20447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20447"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P20447",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20447"
}
]
}
]
},
{
"uniprot_ac": "P20448",
"gene_name": "HCA4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P20448",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20448"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P20448",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20448"
}
]
}
]
},
{
"uniprot_ac": "P20449",
"gene_name": "DBP5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P20449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20449"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P20449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20449"
}
]
}
]
},
{
"uniprot_ac": "P20480",
"gene_name": "ncd",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P20480",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20480"
}
]
}
]
},
{
"uniprot_ac": "P20839",
"gene_name": "IMPDH1",
"activity": [
{
"ec_number": "1.1.1.205",
"activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.",
"evidence": [
{
"id": "P20839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20839"
}
]
},
{
"ec_number": "1.1.1.205",
"activity": "",
"evidence": [
{
"id": "P20839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20839"
}
]
}
]
},
{
"uniprot_ac": "P21372",
"gene_name": "PRP5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P21372",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21372"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P21372",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21372"
}
]
}
]
},
{
"uniprot_ac": "P22392",
"gene_name": "NME2",
"activity": [
{
"ec_number": "2.7.4.6",
"activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.",
"evidence": [
{
"id": "P22392",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22392"
}
]
},
{
"ec_number": "2.7.13.3",
"activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.",
"evidence": [
{
"id": "P22392",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22392"
}
]
},
{
"ec_number": "2.7.4.6",
"activity": "",
"evidence": [
{
"id": "P22392",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22392"
}
]
},
{
"ec_number": "2.7.13.3",
"activity": "",
"evidence": [
{
"id": "P22392",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22392"
}
]
}
]
},
{
"uniprot_ac": "P22516",
"gene_name": "CHL1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P22516",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22516"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P22516",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22516"
}
]
}
]
},
{
"uniprot_ac": "P22681",
"gene_name": "CBL",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P22681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22681"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P22681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22681"
}
]
}
]
},
{
"uniprot_ac": "P23128",
"gene_name": "me31B",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P23128",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23128"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P23128",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23128"
}
]
}
]
},
{
"uniprot_ac": "P23249",
"gene_name": "Mov10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P23249",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23249"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P23249",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23249"
}
]
}
]
},
{
"uniprot_ac": "P23394",
"gene_name": "PRP28",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P23394",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23394"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P23394",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23394"
}
]
}
]
},
{
"uniprot_ac": "P24004",
"gene_name": "PEX1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P24004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24004"
}
]
}
]
},
{
"uniprot_ac": "P24279",
"gene_name": "MCM3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P24279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24279"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P24279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24279"
}
]
}
]
},
{
"uniprot_ac": "P24384",
"gene_name": "PRP22",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P24384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24384"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P24384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24384"
}
]
}
]
},
{
"uniprot_ac": "P24783",
"gene_name": "DBP2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P24783",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24783"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P24783",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24783"
}
]
}
]
},
{
"uniprot_ac": "P24784",
"gene_name": "DBP1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P24784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24784"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P24784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24784"
}
]
}
]
},
{
"uniprot_ac": "P24785",
"gene_name": "mle",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P24785",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24785"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P24785",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24785"
}
]
}
]
},
{
"uniprot_ac": "P24928",
"gene_name": "POLR2A",
"activity": [
{
"ec_number": "2.7.7.6",
"activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).",
"evidence": [
{
"id": "P24928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24928"
}
]
},
{
"ec_number": "2.7.7.6",
"activity": "",
"evidence": [
{
"id": "P24928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24928"
}
]
},
{
"ec_number": "2.7.7.48",
"activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).",
"evidence": [
{
"id": "P24928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24928"
}
]
}
]
},
{
"uniprot_ac": "P25205",
"gene_name": "MCM3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P25205",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25205"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P25205",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25205"
}
]
}
]
},
{
"uniprot_ac": "P25206",
"gene_name": "Mcm3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P25206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25206"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P25206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25206"
}
]
}
]
},
{
"uniprot_ac": "P25439",
"gene_name": "brm",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P25439",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25439"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P25439",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25439"
}
]
}
]
},
{
"uniprot_ac": "P25694",
"gene_name": "CDC48",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P25694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25694"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P25694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25694"
}
]
}
]
},
{
"uniprot_ac": "P25774",
"gene_name": "CTSS",
"activity": [
{
"ec_number": "3.4.22.27",
"activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.",
"evidence": [
{
"id": "P25774",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25774"
}
]
},
{
"ec_number": "3.4.22.27",
"activity": "",
"evidence": [
{
"id": "P25774",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25774"
}
]
}
]
},
{
"uniprot_ac": "P25808",
"gene_name": "SPB4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P25808",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25808"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P25808",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25808"
}
]
}
]
},
{
"uniprot_ac": "P26196",
"gene_name": "DDX6",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P26196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26196"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P26196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26196"
}
]
}
]
},
{
"uniprot_ac": "P26802",
"gene_name": "Dbp73D",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P26802",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26802"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P26802",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26802"
}
]
}
]
},
{
"uniprot_ac": "P28482",
"gene_name": "MAPK1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28482",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28482"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P28482",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28482"
}
]
}
]
},
{
"uniprot_ac": "P28738",
"gene_name": "Kif5c",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P28738",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28738"
}
]
}
]
},
{
"uniprot_ac": "P29469",
"gene_name": "MCM2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P29469",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29469"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P29469",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29469"
}
]
}
]
},
{
"uniprot_ac": "P29496",
"gene_name": "MCM5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P29496",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29496"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P29496",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29496"
}
]
}
]
},
{
"uniprot_ac": "P29844",
"gene_name": "Hsc70-3",
"activity": [
{
"ec_number": "3.6.1.3",
"activity": "",
"evidence": [
{
"id": "P29844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29844"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P29844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29844"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P29844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29844"
}
]
}
]
},
{
"uniprot_ac": "P30665",
"gene_name": "MCM4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P30665",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30665"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P30665",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30665"
}
]
}
]
},
{
"uniprot_ac": "P30771",
"gene_name": "NAM7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P30771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30771"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P30771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30771"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P30771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30771"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P30771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30771"
}
]
}
]
},
{
"uniprot_ac": "P30876",
"gene_name": "POLR2B",
"activity": [
{
"ec_number": "2.7.7.6",
"activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).",
"evidence": [
{
"id": "P30876",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30876"
}
]
},
{
"ec_number": "2.7.7.6",
"activity": "",
"evidence": [
{
"id": "P30876",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30876"
}
]
}
]
},
{
"uniprot_ac": "P31380",
"gene_name": "FUN30",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P31380",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31380"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P31380",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31380"
}
]
}
]
},
{
"uniprot_ac": "P32320",
"gene_name": "CDA",
"activity": [
{
"ec_number": "3.5.4.5",
"activity": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+).",
"evidence": [
{
"id": "P32320",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32320"
}
]
},
{
"ec_number": "3.5.4.5",
"activity": "",
"evidence": [
{
"id": "P32320",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32320"
}
]
}
]
},
{
"uniprot_ac": "P32580",
"gene_name": "SUV3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32580",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32580"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P32580",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32580"
}
]
}
]
},
{
"uniprot_ac": "P32597",
"gene_name": "STH1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32597",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32597"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P32597",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32597"
}
]
}
]
},
{
"uniprot_ac": "P32639",
"gene_name": "BRR2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32639",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32639"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P32639",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32639"
}
]
}
]
},
{
"uniprot_ac": "P32644",
"gene_name": "ECM32",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32644"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P32644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32644"
}
]
}
]
},
{
"uniprot_ac": "P32794",
"gene_name": "AFG2",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32794"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P32794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32794"
}
]
}
]
},
{
"uniprot_ac": "P32807",
"gene_name": "YKU70",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32807",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32807"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P32807",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32807"
}
]
}
]
},
{
"uniprot_ac": "P32863",
"gene_name": "RAD54",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32863",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32863"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P32863",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32863"
}
]
}
]
},
{
"uniprot_ac": "P32892",
"gene_name": "DRS1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P32892",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32892"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P32892",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32892"
}
]
}
]
},
{
"uniprot_ac": "P33760",
"gene_name": "PEX6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P33760",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33760"
}
]
}
]
},
{
"uniprot_ac": "P33991",
"gene_name": "MCM4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P33991",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33991"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P33991",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33991"
}
]
}
]
},
{
"uniprot_ac": "P33992",
"gene_name": "MCM5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P33992",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33992"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P33992",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33992"
}
]
}
]
},
{
"uniprot_ac": "P33993",
"gene_name": "MCM7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P33993",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33993"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P33993",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33993"
}
]
}
]
},
{
"uniprot_ac": "P34243",
"gene_name": "HCS1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P34243",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34243"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P34243",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34243"
}
]
}
]
},
{
"uniprot_ac": "P35187",
"gene_name": "SGS1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P35187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35187"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P35187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35187"
}
]
}
]
},
{
"uniprot_ac": "P35207",
"gene_name": "SKI2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P35207",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35207"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P35207",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35207"
}
]
}
]
},
{
"uniprot_ac": "P36009",
"gene_name": "DHR2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P36009",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36009"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P36009",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36009"
}
]
}
]
},
{
"uniprot_ac": "P36016",
"gene_name": "LHS1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "P36016",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36016"
}
]
}
]
},
{
"uniprot_ac": "P36120",
"gene_name": "DBP7",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P36120",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36120"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P36120",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36120"
}
]
}
]
},
{
"uniprot_ac": "P36871",
"gene_name": "PGM1",
"activity": [
{
"ec_number": "5.4.2.2",
"activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.",
"evidence": [
{
"id": "P36871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36871"
}
]
},
{
"ec_number": "5.4.2.2",
"activity": "",
"evidence": [
{
"id": "P36871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36871"
}
]
}
]
},
{
"uniprot_ac": "P38086",
"gene_name": "RDH54",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38086"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P38086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38086"
}
]
}
]
},
{
"uniprot_ac": "P38112",
"gene_name": "MAK5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38112"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P38112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38112"
}
]
}
]
},
{
"uniprot_ac": "P38132",
"gene_name": "MCM7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38132"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P38132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38132"
}
]
}
]
},
{
"uniprot_ac": "P38712",
"gene_name": "RRP3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38712"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P38712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38712"
}
]
}
]
},
{
"uniprot_ac": "P38719",
"gene_name": "DBP8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38719",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38719"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P38719",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38719"
}
]
}
]
},
{
"uniprot_ac": "P38766",
"gene_name": "RRM3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38766",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38766"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P38766",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38766"
}
]
}
]
},
{
"uniprot_ac": "P38859",
"gene_name": "DNA2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "P38859",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38859"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38859",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38859"
}
]
}
]
},
{
"uniprot_ac": "P38919",
"gene_name": "EIF4A3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38919",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38919"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P38919",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38919"
}
]
}
]
},
{
"uniprot_ac": "P38935",
"gene_name": "IGHMBP2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38935",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38935"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P38935",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38935"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P38935",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38935"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P38935",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38935"
}
]
}
]
},
{
"uniprot_ac": "P39517",
"gene_name": "DHH1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P39517",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39517"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P39517",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39517"
}
]
}
]
},
{
"uniprot_ac": "P40024",
"gene_name": "ARB1",
"activity": [
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "P40024",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40024"
}
]
}
]
},
{
"uniprot_ac": "P40105",
"gene_name": "YRF1-2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40105",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40105"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40105",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40105"
}
]
}
]
},
{
"uniprot_ac": "P40150",
"gene_name": "SSB2",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40150",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40150"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P40150",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40150"
}
]
}
]
},
{
"uniprot_ac": "P40201",
"gene_name": "Chd1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40201",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40201"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40201",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40201"
}
]
}
]
},
{
"uniprot_ac": "P40352",
"gene_name": "RAD26",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40352",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40352"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40352",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40352"
}
]
}
]
},
{
"uniprot_ac": "P40434",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40434",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40434"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40434",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40434"
}
]
}
]
},
{
"uniprot_ac": "P40562",
"gene_name": "MPH1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40562"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40562"
}
]
}
]
},
{
"uniprot_ac": "P40694",
"gene_name": "Ighmbp2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40694"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40694"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P40694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40694"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40694"
}
]
}
]
},
{
"uniprot_ac": "P40889",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P40889",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40889"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P40889",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40889"
}
]
}
]
},
{
"uniprot_ac": "P42285",
"gene_name": "MTREX",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P42285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42285"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P42285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42285"
}
]
}
]
},
{
"uniprot_ac": "P43538",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P43538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43538"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P43538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43538"
}
]
}
]
},
{
"uniprot_ac": "P45818",
"gene_name": "ROK1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P45818",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45818"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P45818",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45818"
}
]
}
]
},
{
"uniprot_ac": "P46063",
"gene_name": "RECQL",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46063",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46063"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P46063",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46063"
}
]
}
]
},
{
"uniprot_ac": "P46100",
"gene_name": "ATRX",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46100"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P46100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46100"
}
]
}
]
},
{
"uniprot_ac": "P46459",
"gene_name": "NSF",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46459"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P46459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46459"
}
]
}
]
},
{
"uniprot_ac": "P46460",
"gene_name": "Nsf",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46460",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46460"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P46460",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46460"
}
]
}
]
},
{
"uniprot_ac": "P46461",
"gene_name": "comt",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46461",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46461"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P46461",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46461"
}
]
}
]
},
{
"uniprot_ac": "P46462",
"gene_name": "Vcp",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46462"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P46462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46462"
}
]
}
]
},
{
"uniprot_ac": "P46467",
"gene_name": "Vps4b",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P46467",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46467"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P46467",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46467"
}
]
}
]
},
{
"uniprot_ac": "P46976",
"gene_name": "GYG1",
"activity": [
{
"ec_number": "2.4.1.186",
"activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.",
"evidence": [
{
"id": "P46976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46976"
}
]
},
{
"ec_number": "2.4.1.186",
"activity": "",
"evidence": [
{
"id": "P46976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46976"
}
]
}
]
},
{
"uniprot_ac": "P47047",
"gene_name": "MTR4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P47047",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47047"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P47047",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47047"
}
]
}
]
},
{
"uniprot_ac": "P49135",
"gene_name": "Ercc3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P49135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49135"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P49135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49135"
}
]
}
]
},
{
"uniprot_ac": "P49717",
"gene_name": "Mcm4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P49717",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49717"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P49717",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49717"
}
]
}
]
},
{
"uniprot_ac": "P49718",
"gene_name": "Mcm5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P49718",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49718"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P49718",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49718"
}
]
}
]
},
{
"uniprot_ac": "P49735",
"gene_name": "Mcm2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P49735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49735"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P49735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49735"
}
]
}
]
},
{
"uniprot_ac": "P49736",
"gene_name": "MCM2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P49736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49736"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P49736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49736"
}
]
}
]
},
{
"uniprot_ac": "P49792",
"gene_name": "RANBP2",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "P49792",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49792"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "P49792",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49792"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "P49792",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49792"
}
]
}
]
},
{
"uniprot_ac": "P49961",
"gene_name": "ENTPD1",
"activity": [
{
"ec_number": "3.6.1.5",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.",
"evidence": [
{
"id": "P49961",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49961"
}
]
},
{
"ec_number": "3.6.1.5",
"activity": "",
"evidence": [
{
"id": "P49961",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49961"
}
]
}
]
},
{
"uniprot_ac": "P50570",
"gene_name": "DNM2",
"activity": [
{
"ec_number": "3.6.5.5",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P50570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50570"
}
]
},
{
"ec_number": "3.6.5.5",
"activity": "",
"evidence": [
{
"id": "P50570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50570"
}
]
}
]
},
{
"uniprot_ac": "P51148",
"gene_name": "RAB5C",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P51148",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51148"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P51148",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51148"
}
]
}
]
},
{
"uniprot_ac": "P51530",
"gene_name": "DNA2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "P51530",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51530"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P51530",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51530"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P51530",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51530"
}
]
}
]
},
{
"uniprot_ac": "P51979",
"gene_name": "HFM1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P51979",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51979"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P51979",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51979"
}
]
}
]
},
{
"uniprot_ac": "P52790",
"gene_name": "HK3",
"activity": [
{
"ec_number": "2.7.1.1",
"activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).",
"evidence": [
{
"id": "P52790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52790"
}
]
},
{
"ec_number": "2.7.1.1",
"activity": "",
"evidence": [
{
"id": "P52790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52790"
}
]
},
{
"ec_number": "2.7.1.-",
"activity": "",
"evidence": [
{
"id": "P52790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52790"
}
]
}
]
},
{
"uniprot_ac": "P53091",
"gene_name": "MCM6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P53091",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53091"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P53091",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53091"
}
]
}
]
},
{
"uniprot_ac": "P53115",
"gene_name": "INO80",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P53115",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53115"
}
]
}
]
},
{
"uniprot_ac": "P53131",
"gene_name": "PRP43",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P53131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53131"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P53131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53131"
}
]
}
]
},
{
"uniprot_ac": "P53166",
"gene_name": "MRH4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P53166",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53166"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P53166",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53166"
}
]
}
]
},
{
"uniprot_ac": "P53327",
"gene_name": "SLH1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P53327",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53327"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P53327",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53327"
}
]
}
]
},
{
"uniprot_ac": "P53396",
"gene_name": "ACLY",
"activity": [
{
"ec_number": "2.3.3.8",
"activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.",
"evidence": [
{
"id": "P53396",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53396"
}
]
},
{
"ec_number": "2.3.3.8",
"activity": "",
"evidence": [
{
"id": "P53396",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53396"
}
]
}
]
},
{
"uniprot_ac": "P53501",
"gene_name": "Act57B",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P53501",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53501"
}
]
}
]
},
{
"uniprot_ac": "P53734",
"gene_name": "DBP6",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P53734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53734"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P53734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53734"
}
]
}
]
},
{
"uniprot_ac": "P53819",
"gene_name": "YRF1-6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P53819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53819"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P53819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53819"
}
]
}
]
},
{
"uniprot_ac": "P53978",
"gene_name": "HEF3",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P53978",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53978"
}
]
}
]
},
{
"uniprot_ac": "P54132",
"gene_name": "BLM",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P54132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54132"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P54132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54132"
}
]
}
]
},
{
"uniprot_ac": "P54278",
"gene_name": "PMS2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "P54278",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54278"
}
]
}
]
},
{
"uniprot_ac": "P54279",
"gene_name": "Pms2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "P54279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54279"
}
]
}
]
},
{
"uniprot_ac": "P54351",
"gene_name": "Nsf2",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P54351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54351"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P54351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54351"
}
]
}
]
},
{
"uniprot_ac": "P54646",
"gene_name": "PRKAA2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54646"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "P54646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54646"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54646"
}
]
}
]
},
{
"uniprot_ac": "P54777",
"gene_name": "Pex6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P54777",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54777"
}
]
}
]
},
{
"uniprot_ac": "P54823",
"gene_name": "Ddx6",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P54823",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54823"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P54823",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54823"
}
]
}
]
},
{
"uniprot_ac": "P55072",
"gene_name": "VCP",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P55072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55072"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "P55072",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55072"
}
]
}
]
},
{
"uniprot_ac": "P55265",
"gene_name": "ADAR",
"activity": [
{
"ec_number": "3.5.4.37",
"activity": "adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+).",
"evidence": [
{
"id": "P55265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55265"
}
]
},
{
"ec_number": "3.5.4.37",
"activity": "",
"evidence": [
{
"id": "P55265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55265"
}
]
}
]
},
{
"uniprot_ac": "P55772",
"gene_name": "Entpd1",
"activity": [
{
"ec_number": "3.6.1.5",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.",
"evidence": [
{
"id": "P55772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55772"
}
]
},
{
"ec_number": "3.6.1.5",
"activity": "",
"evidence": [
{
"id": "P55772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P55772"
}
]
}
]
},
{
"uniprot_ac": "P56536",
"gene_name": "Kif5c",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P56536",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56536"
}
]
}
]
},
{
"uniprot_ac": "P60010",
"gene_name": "ACT1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P60010",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60010"
}
]
}
]
},
{
"uniprot_ac": "P60122",
"gene_name": "Ruvbl1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P60122",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60122"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P60122",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60122"
}
]
}
]
},
{
"uniprot_ac": "P60123",
"gene_name": "Ruvbl1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P60123",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60123"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P60123",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60123"
}
]
}
]
},
{
"uniprot_ac": "P60709",
"gene_name": "ACTB",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P60709",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60709"
}
]
}
]
},
{
"uniprot_ac": "P60710",
"gene_name": "Actb",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P60710",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60710"
}
]
}
]
},
{
"uniprot_ac": "P60711",
"gene_name": "Actb",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P60711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60711"
}
]
}
]
},
{
"uniprot_ac": "P60842",
"gene_name": "EIF4A1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P60842",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60842"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P60842",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60842"
}
]
}
]
},
{
"uniprot_ac": "P60843",
"gene_name": "Eif4a1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P60843",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60843"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P60843",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60843"
}
]
}
]
},
{
"uniprot_ac": "P61221",
"gene_name": "ABCE1",
"activity": [
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "P61221",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61221"
}
]
}
]
},
{
"uniprot_ac": "P61222",
"gene_name": "Abce1",
"activity": [
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "P61222",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61222"
}
]
}
]
},
{
"uniprot_ac": "P62736",
"gene_name": "ACTA2",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P62736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62736"
}
]
}
]
},
{
"uniprot_ac": "P62737",
"gene_name": "Acta2",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P62737",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62737"
}
]
}
]
},
{
"uniprot_ac": "P62738",
"gene_name": "Acta2",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P62738",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62738"
}
]
}
]
},
{
"uniprot_ac": "P62937",
"gene_name": "PPIA",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "P62937",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62937"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "P62937",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62937"
}
]
}
]
},
{
"uniprot_ac": "P63017",
"gene_name": "Hspa8",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P63017",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63017"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P63017",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63017"
}
]
}
]
},
{
"uniprot_ac": "P63018",
"gene_name": "Hspa8",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P63018",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63018"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P63018",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63018"
}
]
}
]
},
{
"uniprot_ac": "P63259",
"gene_name": "Actg1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63259",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63259"
}
]
}
]
},
{
"uniprot_ac": "P63260",
"gene_name": "Actg1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63260"
}
]
}
]
},
{
"uniprot_ac": "P63261",
"gene_name": "ACTG1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63261"
}
]
}
]
},
{
"uniprot_ac": "P63267",
"gene_name": "ACTG2",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63267",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63267"
}
]
}
]
},
{
"uniprot_ac": "P63268",
"gene_name": "Actg2",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63268"
}
]
}
]
},
{
"uniprot_ac": "P63269",
"gene_name": "Actg2",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63269",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63269"
}
]
}
]
},
{
"uniprot_ac": "P68032",
"gene_name": "ACTC1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P68032",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68032"
}
]
}
]
},
{
"uniprot_ac": "P68033",
"gene_name": "Actc1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P68033",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68033"
}
]
}
]
},
{
"uniprot_ac": "P68035",
"gene_name": "Actc1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P68035",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68035"
}
]
}
]
},
{
"uniprot_ac": "P68104",
"gene_name": "EEF1A1",
"activity": [
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "P68104",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68104"
}
]
}
]
},
{
"uniprot_ac": "P68133",
"gene_name": "ACTA1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P68133",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68133"
}
]
}
]
},
{
"uniprot_ac": "P68134",
"gene_name": "Acta1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P68134",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68134"
}
]
}
]
},
{
"uniprot_ac": "P68136",
"gene_name": "Acta1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P68136",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68136"
}
]
}
]
},
{
"uniprot_ac": "P68402",
"gene_name": "PAFAH1B2",
"activity": [
{
"ec_number": "3.1.1.47",
"activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).",
"evidence": [
{
"id": "P68402",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68402"
}
]
},
{
"ec_number": "3.1.1.47",
"activity": "",
"evidence": [
{
"id": "P68402",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68402"
}
]
}
]
},
{
"uniprot_ac": "P70270",
"gene_name": "Rad54l",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P70270",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70270"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P70270",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70270"
}
]
}
]
},
{
"uniprot_ac": "P70486",
"gene_name": "Atrx",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P70486",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70486"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P70486",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70486"
}
]
}
]
},
{
"uniprot_ac": "P82995",
"gene_name": "Hsp90aa1",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P82995",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P82995"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P82995",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P82995"
}
]
}
]
},
{
"uniprot_ac": "P83967",
"gene_name": "Act88F",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P83967",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83967"
}
]
}
]
},
{
"uniprot_ac": "P90529",
"gene_name": "ifdA",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P90529",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P90529"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P90529",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P90529"
}
]
}
]
},
{
"uniprot_ac": "P97310",
"gene_name": "Mcm2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P97310",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97310"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P97310",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97310"
}
]
}
]
},
{
"uniprot_ac": "P97311",
"gene_name": "Mcm6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P97311",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97311"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P97311",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97311"
}
]
}
]
},
{
"uniprot_ac": "P97687",
"gene_name": "Entpd1",
"activity": [
{
"ec_number": "3.6.1.5",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.",
"evidence": [
{
"id": "P97687",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97687"
}
]
},
{
"ec_number": "3.6.1.5",
"activity": "",
"evidence": [
{
"id": "P97687",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97687"
}
]
}
]
},
{
"uniprot_ac": "P97855",
"gene_name": "G3bp1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P97855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97855"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P97855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97855"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "P97855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97855"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "P97855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97855"
}
]
}
]
},
{
"uniprot_ac": "P98066",
"gene_name": "TNFAIP6",
"activity": [
{
"ec_number": "3.1.1.-",
"activity": "",
"evidence": [
{
"id": "P98066",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98066"
}
]
}
]
},
{
"uniprot_ac": "Q00578",
"gene_name": "SSL2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q00578",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00578"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q00578",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00578"
}
]
}
]
},
{
"uniprot_ac": "Q01432",
"gene_name": "AMPD3",
"activity": [
{
"ec_number": "3.5.4.6",
"activity": "AMP + H(+) + H2O = IMP + NH4(+).",
"evidence": [
{
"id": "Q01432",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01432"
}
]
},
{
"ec_number": "3.5.4.6",
"activity": "",
"evidence": [
{
"id": "Q01432",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01432"
}
]
}
]
},
{
"uniprot_ac": "Q01853",
"gene_name": "Vcp",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q01853",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01853"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q01853",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01853"
}
]
}
]
},
{
"uniprot_ac": "Q01968",
"gene_name": "OCRL",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
}
]
},
{
"uniprot_ac": "Q02748",
"gene_name": "eIF4A",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q02748",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02748"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q02748",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02748"
}
]
}
]
},
{
"uniprot_ac": "Q02790",
"gene_name": "FKBP4",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q02790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02790"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q02790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02790"
}
]
}
]
},
{
"uniprot_ac": "Q02870",
"gene_name": "hay",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q02870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02870"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q02870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02870"
}
]
}
]
},
{
"uniprot_ac": "Q03099",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q03099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03099"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q03099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03099"
}
]
}
]
},
{
"uniprot_ac": "Q03468",
"gene_name": "ERCC6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q03468",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03468"
}
]
}
]
},
{
"uniprot_ac": "Q03532",
"gene_name": "HAS1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q03532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03532"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q03532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03532"
}
]
}
]
},
{
"uniprot_ac": "Q03940",
"gene_name": "RVB1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q03940",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03940"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q03940",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03940"
}
]
}
]
},
{
"uniprot_ac": "Q04217",
"gene_name": "ECM16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q04217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04217"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q04217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04217"
}
]
}
]
},
{
"uniprot_ac": "Q04437",
"gene_name": "YKU80",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q04437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04437"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q04437",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04437"
}
]
}
]
},
{
"uniprot_ac": "Q04692",
"gene_name": "Smarcad1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q04692",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04692"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q04692",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04692"
}
]
}
]
},
{
"uniprot_ac": "Q05193",
"gene_name": "DNM1",
"activity": [
{
"ec_number": "3.6.5.5",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "Q05193",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05193"
}
]
},
{
"ec_number": "3.6.5.5",
"activity": "",
"evidence": [
{
"id": "Q05193",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05193"
}
]
}
]
},
{
"uniprot_ac": "Q05329",
"gene_name": "GAD2",
"activity": [
{
"ec_number": "4.1.1.15",
"activity": "H(+) + L-glutamate = 4-aminobutanoate + CO2.",
"evidence": [
{
"id": "Q05329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05329"
}
]
},
{
"ec_number": "4.1.1.15",
"activity": "",
"evidence": [
{
"id": "Q05329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05329"
}
]
}
]
},
{
"uniprot_ac": "Q05471",
"gene_name": "SWR1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q05471",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05471"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q05471",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05471"
}
]
}
]
},
{
"uniprot_ac": "Q05549",
"gene_name": "HRQ1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q05549",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05549"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q05549",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05549"
}
]
}
]
},
{
"uniprot_ac": "Q05931",
"gene_name": "SSQ1",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q05931",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05931"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "Q05931",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05931"
}
]
}
]
},
{
"uniprot_ac": "Q06218",
"gene_name": "DBP9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q06218",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06218"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q06218",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06218"
}
]
}
]
},
{
"uniprot_ac": "Q06698",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q06698",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06698"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q06698",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06698"
}
]
}
]
},
{
"uniprot_ac": "Q07478",
"gene_name": "SUB2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q07478",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07478"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q07478",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07478"
}
]
}
]
},
{
"uniprot_ac": "Q07886",
"gene_name": "Dbp45A",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q07886",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07886"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q07886",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07886"
}
]
}
]
},
{
"uniprot_ac": "Q07888",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q07888",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07888"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q07888",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07888"
}
]
}
]
},
{
"uniprot_ac": "Q08211",
"gene_name": "DHX9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q08211",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08211"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q08211",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08211"
}
]
}
]
},
{
"uniprot_ac": "Q08995",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q08995",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08995"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q08995",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08995"
}
]
}
]
},
{
"uniprot_ac": "Q09472",
"gene_name": "EP300",
"activity": [
{
"ec_number": "2.3.1.48",
"activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].",
"evidence": [
{
"id": "Q09472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09472"
}
]
},
{
"ec_number": "2.3.1.-",
"activity": "",
"evidence": [
{
"id": "Q09472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09472"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "",
"evidence": [
{
"id": "Q09472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09472"
}
]
}
]
},
{
"uniprot_ac": "Q09XV5",
"gene_name": "Chd8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q09XV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09XV5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q09XV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09XV5"
}
]
}
]
},
{
"uniprot_ac": "Q0VGM9",
"gene_name": "Rtel1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q0VGM9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0VGM9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q0VGM9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0VGM9"
}
]
}
]
},
{
"uniprot_ac": "Q0VGT4",
"gene_name": "Zgrf1",
"activity": [
{
"ec_number": "5.6.2.3",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.",
"evidence": [
{
"id": "Q0VGT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0VGT4"
}
]
},
{
"ec_number": "5.6.2.3",
"activity": "",
"evidence": [
{
"id": "Q0VGT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0VGT4"
}
]
}
]
},
{
"uniprot_ac": "Q12039",
"gene_name": "HMI1",
"activity": [
{
"ec_number": "5.6.2.4",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.",
"evidence": [
{
"id": "Q12039",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12039"
}
]
},
{
"ec_number": "5.6.2.4",
"activity": "",
"evidence": [
{
"id": "Q12039",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12039"
}
]
}
]
},
{
"uniprot_ac": "Q12099",
"gene_name": "FAL1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q12099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12099"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q12099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12099"
}
]
}
]
},
{
"uniprot_ac": "Q12389",
"gene_name": "DBP10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q12389",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12389"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q12389",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12389"
}
]
}
]
},
{
"uniprot_ac": "Q12464",
"gene_name": "RVB2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q12464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12464"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q12464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12464"
}
]
}
]
},
{
"uniprot_ac": "Q12697",
"gene_name": "YPK9",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q12697",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12697"
}
]
}
]
},
{
"uniprot_ac": "Q12873",
"gene_name": "CHD3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q12873",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12873"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q12873",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12873"
}
]
}
]
},
{
"uniprot_ac": "Q13162",
"gene_name": "PRDX4",
"activity": [
{
"ec_number": "1.11.1.24",
"activity": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O.",
"evidence": [
{
"id": "Q13162",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13162"
}
]
},
{
"ec_number": "1.11.1.24",
"activity": "",
"evidence": [
{
"id": "Q13162",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13162"
}
]
}
]
},
{
"uniprot_ac": "Q13206",
"gene_name": "DDX10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q13206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13206"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q13206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13206"
}
]
}
]
},
{
"uniprot_ac": "Q13283",
"gene_name": "G3BP1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q13283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13283"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q13283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13283"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q13283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13283"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q13283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13283"
}
]
}
]
},
{
"uniprot_ac": "Q13356",
"gene_name": "PPIL2",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q13356",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13356"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q13356",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13356"
}
]
}
]
},
{
"uniprot_ac": "Q13427",
"gene_name": "PPIG",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q13427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13427"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q13427",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13427"
}
]
}
]
},
{
"uniprot_ac": "Q13451",
"gene_name": "FKBP5",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q13451",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13451"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q13451",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13451"
}
]
}
]
},
{
"uniprot_ac": "Q13464",
"gene_name": "ROCK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13464"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13464"
}
]
}
]
},
{
"uniprot_ac": "Q13510",
"gene_name": "ASAH1",
"activity": [
{
"ec_number": "3.5.1.23",
"activity": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine.",
"evidence": [
{
"id": "Q13510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13510"
}
]
},
{
"ec_number": "3.5.1.23",
"activity": "",
"evidence": [
{
"id": "Q13510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13510"
}
]
},
{
"ec_number": "3.5.1.-",
"activity": "",
"evidence": [
{
"id": "Q13510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13510"
}
]
}
]
},
{
"uniprot_ac": "Q13608",
"gene_name": "PEX6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q13608",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13608"
}
]
}
]
},
{
"uniprot_ac": "Q13838",
"gene_name": "DDX39B",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q13838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13838"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q13838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13838"
}
]
}
]
},
{
"uniprot_ac": "Q14004",
"gene_name": "CDK13",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
}
]
},
{
"uniprot_ac": "Q14147",
"gene_name": "DHX34",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14147"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q14147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14147"
}
]
}
]
},
{
"uniprot_ac": "Q14191",
"gene_name": "WRN",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14191",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14191"
}
]
},
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "Q14191",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14191"
}
]
}
]
},
{
"uniprot_ac": "Q14240",
"gene_name": "EIF4A2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14240",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14240"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q14240",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14240"
}
]
}
]
},
{
"uniprot_ac": "Q14562",
"gene_name": "DHX8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14562"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q14562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14562"
}
]
}
]
},
{
"uniprot_ac": "Q14566",
"gene_name": "MCM6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14566"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q14566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14566"
}
]
}
]
},
{
"uniprot_ac": "Q14839",
"gene_name": "CHD4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14839"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q14839",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14839"
}
]
}
]
},
{
"uniprot_ac": "Q14BI7",
"gene_name": "Tdrd9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q14BI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14BI7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q14BI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14BI7"
}
]
}
]
},
{
"uniprot_ac": "Q15185",
"gene_name": "PTGES3",
"activity": [
{
"ec_number": "5.3.99.3",
"activity": "prostaglandin H2 = prostaglandin E2.",
"evidence": [
{
"id": "Q15185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15185"
}
]
},
{
"ec_number": "5.3.99.3",
"activity": "",
"evidence": [
{
"id": "Q15185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15185"
}
]
}
]
},
{
"uniprot_ac": "Q15477",
"gene_name": "SKIC2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q15477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15477"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q15477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15477"
}
]
}
]
},
{
"uniprot_ac": "Q16539",
"gene_name": "MAPK14",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16539",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16539"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q16539",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16539"
}
]
}
]
},
{
"uniprot_ac": "Q16769",
"gene_name": "QPCT",
"activity": [
{
"ec_number": "2.3.2.5",
"activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).",
"evidence": [
{
"id": "Q16769",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16769"
}
]
},
{
"ec_number": "2.3.2.5",
"activity": "",
"evidence": [
{
"id": "Q16769",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16769"
}
]
}
]
},
{
"uniprot_ac": "Q1HG60",
"gene_name": "Pif1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q1HG60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1HG60"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q1HG60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1HG60"
}
]
}
]
},
{
"uniprot_ac": "Q23976",
"gene_name": "Irbp",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q23976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q23976"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q23976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q23976"
}
]
}
]
},
{
"uniprot_ac": "Q26454",
"gene_name": "dpa",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q26454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q26454"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q26454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q26454"
}
]
}
]
},
{
"uniprot_ac": "Q27268",
"gene_name": "Hel25E",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q27268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q27268"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q27268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q27268"
}
]
}
]
},
{
"uniprot_ac": "Q2KHI9",
"gene_name": "Mcm9",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q2KHI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2KHI9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q2KHI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2KHI9"
}
]
}
]
},
{
"uniprot_ac": "Q2M2I8",
"gene_name": "AAK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q2M2I8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2M2I8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q2M2I8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2M2I8"
}
]
}
]
},
{
"uniprot_ac": "Q2NKX8",
"gene_name": "ERCC6L",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q2NKX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2NKX8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q2NKX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2NKX8"
}
]
}
]
},
{
"uniprot_ac": "Q2VPA6",
"gene_name": "Helq",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q2VPA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2VPA6"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q2VPA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2VPA6"
}
]
}
]
},
{
"uniprot_ac": "Q3B8Q1",
"gene_name": "Ddx21",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3B8Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3B8Q1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q3B8Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3B8Q1"
}
]
}
]
},
{
"uniprot_ac": "Q3B8Q2",
"gene_name": "Eif4a3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3B8Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3B8Q2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q3B8Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3B8Q2"
}
]
}
]
},
{
"uniprot_ac": "Q3E7X8",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3E7X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3E7X8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q3E7X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3E7X8"
}
]
}
]
},
{
"uniprot_ac": "Q3L8U1",
"gene_name": "CHD9",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3L8U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3L8U1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q3L8U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3L8U1"
}
]
}
]
},
{
"uniprot_ac": "Q3MHU3",
"gene_name": "Tdrd9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3MHU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3MHU3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q3MHU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3MHU3"
}
]
}
]
},
{
"uniprot_ac": "Q3TCT4",
"gene_name": "Entpd7",
"activity": [
{
"ec_number": "3.6.1.15",
"activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q3TCT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TCT4"
}
]
},
{
"ec_number": "3.6.1.15",
"activity": "",
"evidence": [
{
"id": "Q3TCT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TCT4"
}
]
}
]
},
{
"uniprot_ac": "Q3TYU2",
"gene_name": "Atp13a5",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q3TYU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TYU2"
}
]
}
]
},
{
"uniprot_ac": "Q3UMC0",
"gene_name": "Afg2a",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3UMC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMC0"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "Q3UMC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMC0"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q3UMC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMC0"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q3UMC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMC0"
}
]
}
]
},
{
"uniprot_ac": "Q4FZF3",
"gene_name": "Ddx49",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q4FZF3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4FZF3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q4FZF3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4FZF3"
}
]
}
]
},
{
"uniprot_ac": "Q4G005",
"gene_name": "Ercc3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q4G005",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4G005"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q4G005",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4G005"
}
]
}
]
},
{
"uniprot_ac": "Q4VNC0",
"gene_name": "ATP13A5",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q4VNC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4VNC0"
}
]
}
]
},
{
"uniprot_ac": "Q4VNC1",
"gene_name": "ATP13A4",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q4VNC1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4VNC1"
}
]
}
]
},
{
"uniprot_ac": "Q501J6",
"gene_name": "Ddx17",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q501J6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q501J6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q501J6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q501J6"
}
]
}
]
},
{
"uniprot_ac": "Q54BD6",
"gene_name": "ddx51",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54BD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54BD6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54BD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54BD6"
}
]
}
]
},
{
"uniprot_ac": "Q54C21",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54C21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C21"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54C21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C21"
}
]
}
]
},
{
"uniprot_ac": "Q54C28",
"gene_name": "rvb1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54C28",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C28"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54C28",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C28"
}
]
}
]
},
{
"uniprot_ac": "Q54CD6",
"gene_name": "ddx5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54CD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CD6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54CD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CD6"
}
]
}
]
},
{
"uniprot_ac": "Q54CD8",
"gene_name": "helA",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54CD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CD8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54CD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CD8"
}
]
}
]
},
{
"uniprot_ac": "Q54CE0",
"gene_name": "ddx17",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54CE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CE0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54CE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CE0"
}
]
}
]
},
{
"uniprot_ac": "Q54CP4",
"gene_name": "mcm5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54CP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CP4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54CP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CP4"
}
]
}
]
},
{
"uniprot_ac": "Q54CS8",
"gene_name": "pex6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54CS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54CS8"
}
]
}
]
},
{
"uniprot_ac": "Q54DG0",
"gene_name": "ino80",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54DG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DG0"
}
]
}
]
},
{
"uniprot_ac": "Q54DM3",
"gene_name": "blm",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54DM3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DM3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54DM3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DM3"
}
]
}
]
},
{
"uniprot_ac": "Q54DN9",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54DN9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DN9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54DN9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DN9"
}
]
}
]
},
{
"uniprot_ac": "Q54E49",
"gene_name": "ddx6",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54E49",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54E49"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54E49",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54E49"
}
]
}
]
},
{
"uniprot_ac": "Q54EC2",
"gene_name": "ddx55",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54EC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EC2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54EC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EC2"
}
]
}
]
},
{
"uniprot_ac": "Q54F05",
"gene_name": "dhx8",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54F05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54F05"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54F05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54F05"
}
]
}
]
},
{
"uniprot_ac": "Q54G57",
"gene_name": "ascc3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54G57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54G57"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54G57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54G57"
}
]
}
]
},
{
"uniprot_ac": "Q54GX5",
"gene_name": "pex1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54GX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54GX5"
}
]
}
]
},
{
"uniprot_ac": "Q54GX7",
"gene_name": "act10",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54GX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54GX7"
}
]
}
]
},
{
"uniprot_ac": "Q54HE7",
"gene_name": "act28",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54HE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HE7"
}
]
}
]
},
{
"uniprot_ac": "Q54HE9",
"gene_name": "act27",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54HE9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HE9"
}
]
}
]
},
{
"uniprot_ac": "Q54HF0",
"gene_name": "act25",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54HF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HF0"
}
]
}
]
},
{
"uniprot_ac": "Q54HF1",
"gene_name": "act24",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54HF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HF1"
}
]
}
]
},
{
"uniprot_ac": "Q54I89",
"gene_name": "upf1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54I89",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54I89"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54I89",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54I89"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54I89",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54I89"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54I89",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54I89"
}
]
}
]
},
{
"uniprot_ac": "Q54IV3",
"gene_name": "ddx42",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54IV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IV3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54IV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IV3"
}
]
}
]
},
{
"uniprot_ac": "Q54KG1",
"gene_name": "ddx41",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54KG1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54KG1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54KG1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54KG1"
}
]
}
]
},
{
"uniprot_ac": "Q54KG8",
"gene_name": "dhx37",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54KG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54KG8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54KG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54KG8"
}
]
}
]
},
{
"uniprot_ac": "Q54L54",
"gene_name": "act29",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q54L54",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54L54"
}
]
}
]
},
{
"uniprot_ac": "Q54LI7",
"gene_name": "BRIP1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54LI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LI7"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54LI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LI7"
}
]
}
]
},
{
"uniprot_ac": "Q54MA9",
"gene_name": "ku70",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54MA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MA9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54MA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MA9"
}
]
}
]
},
{
"uniprot_ac": "Q54MH3",
"gene_name": "dhx16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54MH3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MH3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54MH3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MH3"
}
]
}
]
},
{
"uniprot_ac": "Q54NJ4",
"gene_name": "dhx15",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54NJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54NJ4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54NJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54NJ4"
}
]
}
]
},
{
"uniprot_ac": "Q54NW5",
"gene_name": "",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q54NW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54NW5"
}
]
}
]
},
{
"uniprot_ac": "Q54P22",
"gene_name": "",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q54P22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54P22"
}
]
}
]
},
{
"uniprot_ac": "Q54PT2",
"gene_name": "vps4",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54PT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PT2"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q54PT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PT2"
}
]
}
]
},
{
"uniprot_ac": "Q54Q94",
"gene_name": "ddx10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54Q94",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Q94"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54Q94",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Q94"
}
]
}
]
},
{
"uniprot_ac": "Q54QS3",
"gene_name": "ddx3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54QS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QS3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54QS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QS3"
}
]
}
]
},
{
"uniprot_ac": "Q54RU0",
"gene_name": "MCM7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54RU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RU0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54RU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RU0"
}
]
}
]
},
{
"uniprot_ac": "Q54S03",
"gene_name": "ddx18",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54S03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54S03"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54S03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54S03"
}
]
}
]
},
{
"uniprot_ac": "Q54TD7",
"gene_name": "ddx24",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54TD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TD7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54TD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TD7"
}
]
}
]
},
{
"uniprot_ac": "Q54TF8",
"gene_name": "helC",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54TF8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TF8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54TF8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TF8"
}
]
}
]
},
{
"uniprot_ac": "Q54TJ4",
"gene_name": "ddx27",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54TJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TJ4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54TJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TJ4"
}
]
}
]
},
{
"uniprot_ac": "Q54UW5",
"gene_name": "rvb2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54UW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UW5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54UW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UW5"
}
]
}
]
},
{
"uniprot_ac": "Q54VF1",
"gene_name": "ddx56",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54VF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VF1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54VF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VF1"
}
]
}
]
},
{
"uniprot_ac": "Q54VI9",
"gene_name": "mcm3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54VI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VI9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54VI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VI9"
}
]
}
]
},
{
"uniprot_ac": "Q54VT4",
"gene_name": "ddx47",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54VT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VT4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54VT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VT4"
}
]
}
]
},
{
"uniprot_ac": "Q54X63",
"gene_name": "",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q54X63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54X63"
}
]
}
]
},
{
"uniprot_ac": "Q54XQ3",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54XQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XQ3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54XQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XQ3"
}
]
}
]
},
{
"uniprot_ac": "Q54Y81",
"gene_name": "helB2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54Y81",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y81"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54Y81",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y81"
}
]
}
]
},
{
"uniprot_ac": "Q54Z42",
"gene_name": "PIF1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54Z42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Z42"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q54Z42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Z42"
}
]
}
]
},
{
"uniprot_ac": "Q54ZI9",
"gene_name": "ddx20",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q54ZI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ZI9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q54ZI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ZI9"
}
]
}
]
},
{
"uniprot_ac": "Q553B1",
"gene_name": "helB1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q553B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q553B1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q553B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q553B1"
}
]
}
]
},
{
"uniprot_ac": "Q553U6",
"gene_name": "act22",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q553U6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q553U6"
}
]
}
]
},
{
"uniprot_ac": "Q554S6",
"gene_name": "act17",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q554S6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q554S6"
}
]
}
]
},
{
"uniprot_ac": "Q55A06",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55A06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55A06"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q55A06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55A06"
}
]
}
]
},
{
"uniprot_ac": "Q55BR9",
"gene_name": "ddx49",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55BR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55BR9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q55BR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55BR9"
}
]
}
]
},
{
"uniprot_ac": "Q55CP6",
"gene_name": "ddx1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55CP6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CP6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q55CP6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CP6"
}
]
}
]
},
{
"uniprot_ac": "Q55CU2",
"gene_name": "act26",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q55CU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CU2"
}
]
}
]
},
{
"uniprot_ac": "Q55D61",
"gene_name": "tifA",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55D61",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55D61"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q55D61",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55D61"
}
]
}
]
},
{
"uniprot_ac": "Q55EU6",
"gene_name": "act23",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q55EU6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55EU6"
}
]
}
]
},
{
"uniprot_ac": "Q55F23",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.7.52",
"activity": "RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide.",
"evidence": [
{
"id": "Q55F23",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55F23"
}
]
},
{
"ec_number": "2.7.7.52",
"activity": "",
"evidence": [
{
"id": "Q55F23",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55F23"
}
]
}
]
},
{
"uniprot_ac": "Q55F84",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55F84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55F84"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q55F84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55F84"
}
]
}
]
},
{
"uniprot_ac": "Q55FJ4",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55FJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FJ4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q55FJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FJ4"
}
]
}
]
},
{
"uniprot_ac": "Q55G81",
"gene_name": "repD",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q55G81",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55G81"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q55G81",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55G81"
}
]
}
]
},
{
"uniprot_ac": "Q55GK2",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q55GK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GK2"
}
]
}
]
},
{
"uniprot_ac": "Q569Z5",
"gene_name": "Ddx46",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q569Z5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q569Z5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q569Z5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q569Z5"
}
]
}
]
},
{
"uniprot_ac": "Q587J7",
"gene_name": "TDRD12",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q587J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q587J7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q587J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q587J7"
}
]
}
]
},
{
"uniprot_ac": "Q5BJS0",
"gene_name": "Dhx30",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5BJS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5BJS0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5BJS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5BJS0"
}
]
}
]
},
{
"uniprot_ac": "Q5BL07",
"gene_name": "Pex1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q5BL07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5BL07"
}
]
}
]
},
{
"uniprot_ac": "Q5EBA1",
"gene_name": "Supv3l1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5EBA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EBA1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5EBA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EBA1"
}
]
}
]
},
{
"uniprot_ac": "Q5H9U9",
"gene_name": "DDX60L",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5H9U9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5H9U9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5H9U9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5H9U9"
}
]
}
]
},
{
"uniprot_ac": "Q5RJZ1",
"gene_name": "Rtel1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5RJZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RJZ1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q5RJZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RJZ1"
}
]
}
]
},
{
"uniprot_ac": "Q5RKI1",
"gene_name": "Eif4a2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5RKI1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKI1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5RKI1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKI1"
}
]
}
]
},
{
"uniprot_ac": "Q5SXJ3",
"gene_name": "Brip1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5SXJ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5SXJ3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5SXJ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5SXJ3"
}
]
}
]
},
{
"uniprot_ac": "Q5T1V6",
"gene_name": "DDX59",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5T1V6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T1V6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5T1V6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5T1V6"
}
]
}
]
},
{
"uniprot_ac": "Q5U216",
"gene_name": "Ddx39a",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5U216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U216"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5U216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U216"
}
]
}
]
},
{
"uniprot_ac": "Q5XF90",
"gene_name": "Atp13a4",
"activity": [
{
"ec_number": "7.2.2.-",
"activity": "",
"evidence": [
{
"id": "Q5XF90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XF90"
}
]
}
]
},
{
"uniprot_ac": "Q5XI46",
"gene_name": "Paat",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q5XI46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XI46"
}
]
}
]
},
{
"uniprot_ac": "Q5XI69",
"gene_name": "Dhx40",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5XI69",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XI69"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5XI69",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XI69"
}
]
}
]
},
{
"uniprot_ac": "Q5XIR6",
"gene_name": "Iqcd",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q5XIR6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XIR6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q5XIR6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XIR6"
}
]
}
]
},
{
"uniprot_ac": "Q60649",
"gene_name": "Clpb",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q60649",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60649"
}
]
}
]
},
{
"uniprot_ac": "Q61496",
"gene_name": "Ddx4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q61496",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61496"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q61496",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61496"
}
]
}
]
},
{
"uniprot_ac": "Q61655",
"gene_name": "Ddx19a",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q61655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61655"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q61655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61655"
}
]
}
]
},
{
"uniprot_ac": "Q61656",
"gene_name": "Ddx5",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q61656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61656"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q61656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61656"
}
]
}
]
},
{
"uniprot_ac": "Q61687",
"gene_name": "Atrx",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q61687",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61687"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q61687",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61687"
}
]
}
]
},
{
"uniprot_ac": "Q61881",
"gene_name": "Mcm7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q61881",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61881"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q61881",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61881"
}
]
}
]
},
{
"uniprot_ac": "Q62095",
"gene_name": "Ddx3y",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q62095",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62095"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q62095",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62095"
}
]
}
]
},
{
"uniprot_ac": "Q62167",
"gene_name": "Ddx3x",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q62167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62167"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q62167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62167"
}
]
}
]
},
{
"uniprot_ac": "Q62724",
"gene_name": "Mcm6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q62724",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62724"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q62724",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62724"
}
]
}
]
},
{
"uniprot_ac": "Q62780",
"gene_name": "Ddx46",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q62780",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62780"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q62780",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62780"
}
]
}
]
},
{
"uniprot_ac": "Q63413",
"gene_name": "Ddx39b",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q63413",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63413"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q63413",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63413"
}
]
}
]
},
{
"uniprot_ac": "Q63HN8",
"gene_name": "RNF213",
"activity": [
{
"ec_number": "2.3.2.-",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q63HN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63HN8"
}
]
}
]
},
{
"uniprot_ac": "Q64060",
"gene_name": "Ddx4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q64060",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64060"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q64060",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64060"
}
]
}
]
},
{
"uniprot_ac": "Q641Y8",
"gene_name": "Ddx1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q641Y8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641Y8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q641Y8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641Y8"
}
]
}
]
},
{
"uniprot_ac": "Q66HG7",
"gene_name": "Ddx59",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q66HG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HG7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q66HG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HG7"
}
]
}
]
},
{
"uniprot_ac": "Q68G38",
"gene_name": "Tor1a",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q68G38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q68G38"
}
]
}
]
},
{
"uniprot_ac": "Q69ZX6",
"gene_name": "Morc2a",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q69ZX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZX6"
}
]
}
]
},
{
"uniprot_ac": "Q6AXC6",
"gene_name": "Ddx11",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6AXC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6AXC6"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q6AXC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6AXC6"
}
]
}
]
},
{
"uniprot_ac": "Q6AYJ1",
"gene_name": "Recql",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6AYJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6AYJ1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q6AYJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6AYJ1"
}
]
}
]
},
{
"uniprot_ac": "Q6GX84",
"gene_name": "Fignl1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q6GX84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6GX84"
}
]
}
]
},
{
"uniprot_ac": "Q6J5K9",
"gene_name": "armi",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6J5K9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6J5K9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6J5K9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6J5K9"
}
]
}
]
},
{
"uniprot_ac": "Q6MG13",
"gene_name": "Dhx16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6MG13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6MG13"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6MG13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6MG13"
}
]
}
]
},
{
"uniprot_ac": "Q6NQY9",
"gene_name": "cg9143",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6NQY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NQY9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6NQY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NQY9"
}
]
}
]
},
{
"uniprot_ac": "Q6NVF4",
"gene_name": "Helb",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6NVF4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q6NVF4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF4"
}
]
}
]
},
{
"uniprot_ac": "Q6NZL1",
"gene_name": "Dhx37",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6NZL1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NZL1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6NZL1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NZL1"
}
]
}
]
},
{
"uniprot_ac": "Q6NZQ2",
"gene_name": "Ddx31",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6NZQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NZQ2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6NZQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NZQ2"
}
]
}
]
},
{
"uniprot_ac": "Q6NZR5",
"gene_name": "Skic2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6NZR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NZR5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6NZR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NZR5"
}
]
}
]
},
{
"uniprot_ac": "Q6P158",
"gene_name": "DHX57",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6P158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P158"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6P158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P158"
}
]
}
]
},
{
"uniprot_ac": "Q6P3V8",
"gene_name": "Eif4a1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6P3V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3V8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6P3V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3V8"
}
]
}
]
},
{
"uniprot_ac": "Q6P4T2",
"gene_name": "Snrnp200",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6P4T2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P4T2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6P4T2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P4T2"
}
]
}
]
},
{
"uniprot_ac": "Q6P5D3",
"gene_name": "Dhx57",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6P5D3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5D3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6P5D3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5D3"
}
]
}
]
},
{
"uniprot_ac": "Q6P5D8",
"gene_name": "Smchd1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q6P5D8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5D8"
}
]
}
]
},
{
"uniprot_ac": "Q6P9R1",
"gene_name": "Ddx51",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6P9R1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P9R1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6P9R1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P9R1"
}
]
}
]
},
{
"uniprot_ac": "Q6PDQ2",
"gene_name": "Chd4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6PDQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PDQ2"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q6PDQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PDQ2"
}
]
}
]
},
{
"uniprot_ac": "Q6PE54",
"gene_name": "Dhx40",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6PE54",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PE54"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6PE54",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PE54"
}
]
}
]
},
{
"uniprot_ac": "Q6PGC1",
"gene_name": "Dhx29",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6PGC1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PGC1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6PGC1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PGC1"
}
]
}
]
},
{
"uniprot_ac": "Q6PIW4",
"gene_name": "FIGNL1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q6PIW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PIW4"
}
]
}
]
},
{
"uniprot_ac": "Q6PL18",
"gene_name": "ATAD2",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q6PL18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PL18"
}
]
}
]
},
{
"uniprot_ac": "Q6Q899",
"gene_name": "Rigi",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6Q899",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6Q899"
}
]
}
]
},
{
"uniprot_ac": "Q6ZPL9",
"gene_name": "Ddx55",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6ZPL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZPL9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q6ZPL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZPL9"
}
]
}
]
},
{
"uniprot_ac": "Q6ZPV2",
"gene_name": "Ino80",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q6ZPV2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZPV2"
}
]
}
]
},
{
"uniprot_ac": "Q6ZQJ5",
"gene_name": "Dna2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "Q6ZQJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZQJ5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q6ZQJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZQJ5"
}
]
}
]
},
{
"uniprot_ac": "Q75JA0",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q75JA0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JA0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q75JA0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JA0"
}
]
}
]
},
{
"uniprot_ac": "Q75JI3",
"gene_name": "nsfA",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q75JI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JI3"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q75JI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JI3"
}
]
}
]
},
{
"uniprot_ac": "Q75JU2",
"gene_name": "wrnip1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q75JU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JU2"
}
]
}
]
},
{
"uniprot_ac": "Q75NR7",
"gene_name": "Recql4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q75NR7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75NR7"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q75NR7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75NR7"
}
]
}
]
},
{
"uniprot_ac": "Q793F9",
"gene_name": "Vps4a",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q793F9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q793F9"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q793F9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q793F9"
}
]
}
]
},
{
"uniprot_ac": "Q7K3M5",
"gene_name": "Dhx15",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7K3M5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7K3M5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q7K3M5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7K3M5"
}
]
}
]
},
{
"uniprot_ac": "Q7KN62",
"gene_name": "TER94",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7KN62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KN62"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q7KN62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KN62"
}
]
}
]
},
{
"uniprot_ac": "Q7KU24",
"gene_name": "Chd1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7KU24",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KU24"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q7KU24",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KU24"
}
]
}
]
},
{
"uniprot_ac": "Q7KVP9",
"gene_name": "Xpd",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7KVP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KVP9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q7KVP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KVP9"
}
]
}
]
},
{
"uniprot_ac": "Q7L014",
"gene_name": "DDX46",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7L014",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L014"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q7L014",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L014"
}
]
}
]
},
{
"uniprot_ac": "Q7L2E3",
"gene_name": "DHX30",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7L2E3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L2E3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q7L2E3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L2E3"
}
]
}
]
},
{
"uniprot_ac": "Q7L7V1",
"gene_name": "DHX32",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7L7V1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L7V1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q7L7V1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L7V1"
}
]
}
]
},
{
"uniprot_ac": "Q7Z478",
"gene_name": "DHX29",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q7Z478",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z478"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q7Z478",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z478"
}
]
}
]
},
{
"uniprot_ac": "Q7Z6Z7",
"gene_name": "HUWE1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q7Z6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6Z7"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q7Z6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z6Z7"
}
]
}
]
},
{
"uniprot_ac": "Q80SX8",
"gene_name": "Pif1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q80SX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80SX8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q80SX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80SX8"
}
]
}
]
},
{
"uniprot_ac": "Q80VY9",
"gene_name": "Dhx33",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q80VY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80VY9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q80VY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80VY9"
}
]
}
]
},
{
"uniprot_ac": "Q80X98",
"gene_name": "Dhx38",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q80X98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80X98"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q80X98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80X98"
}
]
}
]
},
{
"uniprot_ac": "Q80Y44",
"gene_name": "Ddx10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q80Y44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80Y44"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q80Y44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80Y44"
}
]
}
]
},
{
"uniprot_ac": "Q80YD1",
"gene_name": "Supv3l1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q80YD1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YD1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q80YD1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YD1"
}
]
}
]
},
{
"uniprot_ac": "Q810A7",
"gene_name": "Ddx42",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q810A7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q810A7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q810A7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q810A7"
}
]
}
]
},
{
"uniprot_ac": "Q869P0",
"gene_name": "ddx31",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q869P0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869P0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q869P0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869P0"
}
]
}
]
},
{
"uniprot_ac": "Q869Z1",
"gene_name": "dhx9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q869Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869Z1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q869Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869Z1"
}
]
}
]
},
{
"uniprot_ac": "Q86B14",
"gene_name": "mcm6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q86B14",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86B14"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q86B14",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86B14"
}
]
}
]
},
{
"uniprot_ac": "Q86B47",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q86B47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86B47"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q86B47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86B47"
}
]
}
]
},
{
"uniprot_ac": "Q86IF1",
"gene_name": "mcm4",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q86IF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86IF1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q86IF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86IF1"
}
]
}
]
},
{
"uniprot_ac": "Q86IZ9",
"gene_name": "ddx52",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q86IZ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86IZ9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q86IZ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86IZ9"
}
]
}
]
},
{
"uniprot_ac": "Q86TM3",
"gene_name": "DDX53",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q86TM3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86TM3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q86TM3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86TM3"
}
]
}
]
},
{
"uniprot_ac": "Q86WJ1",
"gene_name": "CHD1L",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q86WJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86WJ1"
}
]
}
]
},
{
"uniprot_ac": "Q86XP3",
"gene_name": "DDX42",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q86XP3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XP3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q86XP3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86XP3"
}
]
}
]
},
{
"uniprot_ac": "Q86YA3",
"gene_name": "ZGRF1",
"activity": [
{
"ec_number": "5.6.2.3",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.",
"evidence": [
{
"id": "Q86YA3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86YA3"
}
]
},
{
"ec_number": "5.6.2.3",
"activity": "",
"evidence": [
{
"id": "Q86YA3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86YA3"
}
]
}
]
},
{
"uniprot_ac": "Q8BGE5",
"gene_name": "Fancm",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8BGE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BGE5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8BGE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BGE5"
}
]
}
]
},
{
"uniprot_ac": "Q8BHK9",
"gene_name": "Ercc6l",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8BHK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BHK9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8BHK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BHK9"
}
]
}
]
},
{
"uniprot_ac": "Q8BPY9",
"gene_name": "Fignl1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q8BPY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BPY9"
}
]
}
]
},
{
"uniprot_ac": "Q8BYH8",
"gene_name": "Chd9",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8BYH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BYH8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8BYH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BYH8"
}
]
}
]
},
{
"uniprot_ac": "Q8BZS9",
"gene_name": "Dhx32",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8BZS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZS9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8BZS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZS9"
}
]
}
]
},
{
"uniprot_ac": "Q8C5W4",
"gene_name": "Morc2b",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q8C5W4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C5W4"
}
]
}
]
},
{
"uniprot_ac": "Q8CDM1",
"gene_name": "Atad2",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q8CDM1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CDM1"
}
]
}
]
},
{
"uniprot_ac": "Q8CFQ3",
"gene_name": "Aqr",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8CFQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CFQ3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8CFQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CFQ3"
}
]
}
]
},
{
"uniprot_ac": "Q8CG07",
"gene_name": "Wrnip1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q8CG07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CG07"
}
]
}
]
},
{
"uniprot_ac": "Q8CGS6",
"gene_name": "Polq",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8CGS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGS6"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q8CGS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGS6"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q8CGS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGS6"
}
]
}
]
},
{
"uniprot_ac": "Q8CIW5",
"gene_name": "Twnk",
"activity": [
{
"ec_number": "5.6.2.3",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.",
"evidence": [
{
"id": "Q8CIW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIW5"
}
]
},
{
"ec_number": "5.6.2.3",
"activity": "",
"evidence": [
{
"id": "Q8CIW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIW5"
}
]
}
]
},
{
"uniprot_ac": "Q8ING5",
"gene_name": "Dmel\\CG31495",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8ING5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8ING5"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q8ING5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8ING5"
}
]
}
]
},
{
"uniprot_ac": "Q8IRL9",
"gene_name": "Dna2",
"activity": [
{
"ec_number": "3.1.-.-",
"activity": "",
"evidence": [
{
"id": "Q8IRL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IRL9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IRL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IRL9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8IRL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IRL9"
}
]
}
]
},
{
"uniprot_ac": "Q8IVL1",
"gene_name": "NAV2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IVL1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVL1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8IVL1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVL1"
}
]
}
]
},
{
"uniprot_ac": "Q8IX18",
"gene_name": "DHX40",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IX18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IX18"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8IX18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IX18"
}
]
}
]
},
{
"uniprot_ac": "Q8IY21",
"gene_name": "DDX60",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IY21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IY21"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8IY21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IY21"
}
]
}
]
},
{
"uniprot_ac": "Q8IY37",
"gene_name": "DHX37",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IY37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IY37"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8IY37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IY37"
}
]
}
]
},
{
"uniprot_ac": "Q8IYB8",
"gene_name": "SUPV3L1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IYB8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYB8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8IYB8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYB8"
}
]
}
]
},
{
"uniprot_ac": "Q8IYD8",
"gene_name": "FANCM",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8IYD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYD8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8IYD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYD8"
}
]
}
]
},
{
"uniprot_ac": "Q8K2I9",
"gene_name": "Fbh1",
"activity": [
{
"ec_number": "5.6.2.4",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.",
"evidence": [
{
"id": "Q8K2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K2I9"
}
]
},
{
"ec_number": "5.6.2.4",
"activity": "",
"evidence": [
{
"id": "Q8K2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K2I9"
}
]
}
]
},
{
"uniprot_ac": "Q8K301",
"gene_name": "Ddx52",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8K301",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K301"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8K301",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K301"
}
]
}
]
},
{
"uniprot_ac": "Q8K363",
"gene_name": "Ddx18",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8K363",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K363"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8K363",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K363"
}
]
}
]
},
{
"uniprot_ac": "Q8K4L0",
"gene_name": "Ddx54",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8K4L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4L0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8K4L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4L0"
}
]
}
]
},
{
"uniprot_ac": "Q8N3C0",
"gene_name": "ASCC3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8N3C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N3C0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8N3C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N3C0"
}
]
}
]
},
{
"uniprot_ac": "Q8N8A6",
"gene_name": "DDX51",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8N8A6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N8A6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8N8A6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N8A6"
}
]
}
]
},
{
"uniprot_ac": "Q8NB90",
"gene_name": "AFG2A",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8NB90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NB90"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "Q8NB90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NB90"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8NB90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NB90"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q8NB90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NB90"
}
]
}
]
},
{
"uniprot_ac": "Q8NBS9",
"gene_name": "TXNDC5",
"activity": [
{
"ec_number": "1.8.4.-",
"activity": "",
"evidence": [
{
"id": "Q8NBS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBS9"
}
]
},
{
"ec_number": "5.3.4.1",
"activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.",
"evidence": [
{
"id": "Q8NBS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBS9"
}
]
},
{
"ec_number": "5.3.4.1",
"activity": "",
"evidence": [
{
"id": "Q8NBS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBS9"
}
]
}
]
},
{
"uniprot_ac": "Q8NDG6",
"gene_name": "TDRD9",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8NDG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NDG6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8NDG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NDG6"
}
]
}
]
},
{
"uniprot_ac": "Q8NFZ0",
"gene_name": "FBH1",
"activity": [
{
"ec_number": "5.6.2.4",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.",
"evidence": [
{
"id": "Q8NFZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFZ0"
}
]
},
{
"ec_number": "5.6.2.4",
"activity": "",
"evidence": [
{
"id": "Q8NFZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFZ0"
}
]
}
]
},
{
"uniprot_ac": "Q8NG08",
"gene_name": "HELB",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8NG08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG08"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8NG08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG08"
}
]
}
]
},
{
"uniprot_ac": "Q8NHQ9",
"gene_name": "DDX55",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8NHQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NHQ9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8NHQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NHQ9"
}
]
}
]
},
{
"uniprot_ac": "Q8R4B8",
"gene_name": "Nlrp3",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q8R4B8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4B8"
}
]
}
]
},
{
"uniprot_ac": "Q8R5F7",
"gene_name": "Ifih1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8R5F7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R5F7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8R5F7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R5F7"
}
]
}
]
},
{
"uniprot_ac": "Q8SWT2",
"gene_name": "Rhau",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8SWT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SWT2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8SWT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SWT2"
}
]
}
]
},
{
"uniprot_ac": "Q8SY39",
"gene_name": "CG6994",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8SY39",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SY39"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8SY39",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SY39"
}
]
}
]
},
{
"uniprot_ac": "Q8TD26",
"gene_name": "CHD6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8TD26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TD26"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8TD26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TD26"
}
]
}
]
},
{
"uniprot_ac": "Q8TDD1",
"gene_name": "DDX54",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8TDD1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDD1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8TDD1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDD1"
}
]
}
]
},
{
"uniprot_ac": "Q8TDG4",
"gene_name": "HELQ",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8TDG4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDG4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8TDG4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDG4"
}
]
}
]
},
{
"uniprot_ac": "Q8TDI0",
"gene_name": "CHD5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8TDI0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDI0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8TDI0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDI0"
}
]
}
]
},
{
"uniprot_ac": "Q8TE96",
"gene_name": "DQX1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8TE96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TE96"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8TE96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TE96"
}
]
}
]
},
{
"uniprot_ac": "Q8VDW0",
"gene_name": "Ddx39a",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8VDW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDW0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8VDW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDW0"
}
]
}
]
},
{
"uniprot_ac": "Q8VEJ9",
"gene_name": "Vps4a",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8VEJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VEJ9"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q8VEJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VEJ9"
}
]
}
]
},
{
"uniprot_ac": "Q8VHK9",
"gene_name": "Dhx36",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8VHK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q8VHK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHK9"
}
]
}
]
},
{
"uniprot_ac": "Q8VID5",
"gene_name": "Recql5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8VID5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VID5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q8VID5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VID5"
}
]
}
]
},
{
"uniprot_ac": "Q8WUA2",
"gene_name": "PPIL4",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q8WUA2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WUA2"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q8WUA2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WUA2"
}
]
}
]
},
{
"uniprot_ac": "Q8WVQ1",
"gene_name": "CANT1",
"activity": [
{
"ec_number": "3.6.1.6",
"activity": "ADP + H2O = AMP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8WVQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVQ1"
}
]
},
{
"ec_number": "3.6.1.6",
"activity": "",
"evidence": [
{
"id": "Q8WVQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WVQ1"
}
]
}
]
},
{
"uniprot_ac": "Q8WXB1",
"gene_name": "METTL21A",
"activity": [
{
"ec_number": "2.1.1.-",
"activity": "",
"evidence": [
{
"id": "Q8WXB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WXB1"
}
]
}
]
},
{
"uniprot_ac": "Q91VC3",
"gene_name": "Eif4a3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q91VC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VC3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q91VC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VC3"
}
]
}
]
},
{
"uniprot_ac": "Q91VN6",
"gene_name": "Ddx41",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q91VN6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VN6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q91VN6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VN6"
}
]
}
]
},
{
"uniprot_ac": "Q91VR5",
"gene_name": "Ddx1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q91VR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VR5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q91VR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VR5"
}
]
}
]
},
{
"uniprot_ac": "Q91XU0",
"gene_name": "Wrnip1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q91XU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XU0"
}
]
}
]
},
{
"uniprot_ac": "Q921N6",
"gene_name": "Ddx27",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q921N6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q921N6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q921N6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q921N6"
}
]
}
]
},
{
"uniprot_ac": "Q92499",
"gene_name": "DDX1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92499",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92499"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q92499",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92499"
}
]
}
]
},
{
"uniprot_ac": "Q924H9",
"gene_name": "Dqx1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q924H9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924H9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q924H9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924H9"
}
]
}
]
},
{
"uniprot_ac": "Q92620",
"gene_name": "DHX38",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92620",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92620"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q92620",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92620"
}
]
}
]
},
{
"uniprot_ac": "Q92698",
"gene_name": "RAD54L",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92698",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92698"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q92698",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92698"
}
]
}
]
},
{
"uniprot_ac": "Q92771",
"gene_name": "DDX12P",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92771"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q92771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92771"
}
]
}
]
},
{
"uniprot_ac": "Q92793",
"gene_name": "CREBBP",
"activity": [
{
"ec_number": "2.3.1.48",
"activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].",
"evidence": [
{
"id": "Q92793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92793"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "",
"evidence": [
{
"id": "Q92793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92793"
}
]
},
{
"ec_number": "2.3.1.-",
"activity": "",
"evidence": [
{
"id": "Q92793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92793"
}
]
}
]
},
{
"uniprot_ac": "Q92841",
"gene_name": "DDX17",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92841",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92841"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q92841",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92841"
}
]
}
]
},
{
"uniprot_ac": "Q92900",
"gene_name": "UPF1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92900",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92900"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q92900",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92900"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q92900",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92900"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q92900",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92900"
}
]
}
]
},
{
"uniprot_ac": "Q96BP3",
"gene_name": "PPWD1",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q96BP3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BP3"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q96BP3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BP3"
}
]
}
]
},
{
"uniprot_ac": "Q96C10",
"gene_name": "DHX58",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q96C10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96C10"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q96C10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96C10"
}
]
}
]
},
{
"uniprot_ac": "Q96EB6",
"gene_name": "SIRT1",
"activity": [
{
"ec_number": "2.3.1.-",
"activity": "",
"evidence": [
{
"id": "Q96EB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96EB6"
}
]
},
{
"ec_number": "2.3.1.286",
"activity": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.",
"evidence": [
{
"id": "Q96EB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96EB6"
}
]
},
{
"ec_number": "2.3.1.286",
"activity": "",
"evidence": [
{
"id": "Q96EB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96EB6"
}
]
}
]
},
{
"uniprot_ac": "Q96FC9",
"gene_name": "DDX11",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q96FC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96FC9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q96FC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96FC9"
}
]
}
]
},
{
"uniprot_ac": "Q96G03",
"gene_name": "PGM2",
"activity": [
{
"ec_number": "5.4.2.2",
"activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.",
"evidence": [
{
"id": "Q96G03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96G03"
}
]
},
{
"ec_number": "5.4.2.7",
"activity": "2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate.",
"evidence": [
{
"id": "Q96G03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96G03"
}
]
},
{
"ec_number": "5.4.2.7",
"activity": "",
"evidence": [
{
"id": "Q96G03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96G03"
}
]
}
]
},
{
"uniprot_ac": "Q96GQ7",
"gene_name": "DDX27",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q96GQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GQ7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q96GQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GQ7"
}
]
}
]
},
{
"uniprot_ac": "Q96P20",
"gene_name": "NLRP3",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q96P20",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96P20"
}
]
}
]
},
{
"uniprot_ac": "Q96RR1",
"gene_name": "TWNK",
"activity": [
{
"ec_number": "5.6.2.3",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.",
"evidence": [
{
"id": "Q96RR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96RR1"
}
]
},
{
"ec_number": "5.6.2.3",
"activity": "",
"evidence": [
{
"id": "Q96RR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96RR1"
}
]
}
]
},
{
"uniprot_ac": "Q96S55",
"gene_name": "WRNIP1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q96S55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S55"
}
]
}
]
},
{
"uniprot_ac": "Q99208",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99208",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99208"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q99208",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99208"
}
]
}
]
},
{
"uniprot_ac": "Q99259",
"gene_name": "GAD1",
"activity": [
{
"ec_number": "4.1.1.15",
"activity": "H(+) + L-glutamate = 4-aminobutanoate + CO2.",
"evidence": [
{
"id": "Q99259",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99259"
}
]
},
{
"ec_number": "4.1.1.15",
"activity": "",
"evidence": [
{
"id": "Q99259",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99259"
}
]
}
]
},
{
"uniprot_ac": "Q99436",
"gene_name": "PSMB7",
"activity": [
{
"ec_number": "3.4.25.1",
"activity": "Cleavage of peptide bonds with very broad specificity.",
"evidence": [
{
"id": "Q99436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99436"
}
]
},
{
"ec_number": "3.4.25.1",
"activity": "",
"evidence": [
{
"id": "Q99436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99436"
}
]
}
]
},
{
"uniprot_ac": "Q99497",
"gene_name": "PARK7",
"activity": [
{
"ec_number": "3.5.1.124",
"activity": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate.",
"evidence": [
{
"id": "Q99497",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99497"
}
]
},
{
"ec_number": "3.5.1.124",
"activity": "",
"evidence": [
{
"id": "Q99497",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99497"
}
]
},
{
"ec_number": "3.1.2.-",
"activity": "",
"evidence": [
{
"id": "Q99497",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99497"
}
]
},
{
"ec_number": "3.5.1.-",
"activity": "",
"evidence": [
{
"id": "Q99497",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99497"
}
]
}
]
},
{
"uniprot_ac": "Q99J87",
"gene_name": "Dhx58",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99J87",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J87"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q99J87",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J87"
}
]
}
]
},
{
"uniprot_ac": "Q99LC9",
"gene_name": "Pex6",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q99LC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99LC9"
}
]
}
]
},
{
"uniprot_ac": "Q99MJ9",
"gene_name": "Ddx50",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99MJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MJ9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q99MJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MJ9"
}
]
}
]
},
{
"uniprot_ac": "Q99MV5",
"gene_name": "Mov10l1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99MV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MV5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q99MV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MV5"
}
]
}
]
},
{
"uniprot_ac": "Q99NG0",
"gene_name": "Rad54l2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99NG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99NG0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q99NG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99NG0"
}
]
}
]
},
{
"uniprot_ac": "Q99PT0",
"gene_name": "Ddx52",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99PT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PT0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q99PT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PT0"
}
]
}
]
},
{
"uniprot_ac": "Q99PU8",
"gene_name": "Dhx30",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q99PU8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PU8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q99PU8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PU8"
}
]
}
]
},
{
"uniprot_ac": "Q9BQ39",
"gene_name": "DDX50",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BQ39",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BQ39"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9BQ39",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BQ39"
}
]
}
]
},
{
"uniprot_ac": "Q9BSD7",
"gene_name": "NTPCR",
"activity": [
{
"ec_number": "3.6.1.15",
"activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BSD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BSD7"
}
]
},
{
"ec_number": "3.6.1.15",
"activity": "",
"evidence": [
{
"id": "Q9BSD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BSD7"
}
]
}
]
},
{
"uniprot_ac": "Q9BUQ8",
"gene_name": "DDX23",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BUQ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BUQ8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9BUQ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BUQ8"
}
]
}
]
},
{
"uniprot_ac": "Q9BVQ7",
"gene_name": "AFG2B",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BVQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BVQ7"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "Q9BVQ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BVQ7"
}
]
}
]
},
{
"uniprot_ac": "Q9BX63",
"gene_name": "BRIP1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BX63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BX63"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9BX63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BX63"
}
]
}
]
},
{
"uniprot_ac": "Q9BXT6",
"gene_name": "MOV10L1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BXT6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXT6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9BXT6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXT6"
}
]
}
]
},
{
"uniprot_ac": "Q9BYK8",
"gene_name": "HELZ2",
"activity": [
{
"ec_number": "3.1.13.1",
"activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.",
"evidence": [
{
"id": "Q9BYK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYK8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BYK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYK8"
}
]
},
{
"ec_number": "3.1.13.1",
"activity": "",
"evidence": [
{
"id": "Q9BYK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYK8"
}
]
}
]
},
{
"uniprot_ac": "Q9BYX4",
"gene_name": "IFIH1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9BYX4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYX4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9BYX4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYX4"
}
]
}
]
},
{
"uniprot_ac": "Q9C000",
"gene_name": "NLRP1",
"activity": [
{
"ec_number": "3.4.-.-",
"activity": "",
"evidence": [
{
"id": "Q9C000",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C000"
}
]
},
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9C000",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C000"
}
]
}
]
},
{
"uniprot_ac": "Q9CQA9",
"gene_name": "Ntpcr",
"activity": [
{
"ec_number": "3.6.1.15",
"activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q9CQA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CQA9"
}
]
},
{
"ec_number": "3.6.1.15",
"activity": "",
"evidence": [
{
"id": "Q9CQA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CQA9"
}
]
}
]
},
{
"uniprot_ac": "Q9CWT6",
"gene_name": "Ddx28",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9CWT6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWT6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9CWT6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWT6"
}
]
}
]
},
{
"uniprot_ac": "Q9CWU0",
"gene_name": "Tdrd12",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9CWU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWU0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9CWU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWU0"
}
]
}
]
},
{
"uniprot_ac": "Q9CWV1",
"gene_name": "Mcm8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9CWV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWV1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9CWV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWV1"
}
]
}
]
},
{
"uniprot_ac": "Q9CWX9",
"gene_name": "Ddx47",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9CWX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWX9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9CWX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CWX9"
}
]
}
]
},
{
"uniprot_ac": "Q9CXF7",
"gene_name": "Chd1l",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9CXF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CXF7"
}
]
}
]
},
{
"uniprot_ac": "Q9CZU3",
"gene_name": "Mtrex",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9CZU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CZU3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9CZU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CZU3"
}
]
}
]
},
{
"uniprot_ac": "Q9D0R4",
"gene_name": "Ddx56",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9D0R4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D0R4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9D0R4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D0R4"
}
]
}
]
},
{
"uniprot_ac": "Q9D2Q3",
"gene_name": "Paat",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q9D2Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D2Q3"
}
]
}
]
},
{
"uniprot_ac": "Q9DBN9",
"gene_name": "Ddx59",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9DBN9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBN9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9DBN9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBN9"
}
]
}
]
},
{
"uniprot_ac": "Q9DBV3",
"gene_name": "Dhx34",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9DBV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBV3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9DBV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBV3"
}
]
}
]
},
{
"uniprot_ac": "Q9EPU0",
"gene_name": "Upf1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9EPU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EPU0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9EPU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EPU0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9EPU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EPU0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9EPU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EPU0"
}
]
}
]
},
{
"uniprot_ac": "Q9EQN5",
"gene_name": "Ighmbp2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9EQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQN5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9EQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQN5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9EQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQN5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9EQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQN5"
}
]
}
]
},
{
"uniprot_ac": "Q9ER39",
"gene_name": "Tor1a",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9ER39",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ER39"
}
]
}
]
},
{
"uniprot_ac": "Q9ER41",
"gene_name": "Tor1b",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9ER41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ER41"
}
]
}
]
},
{
"uniprot_ac": "Q9ESV0",
"gene_name": "Ddx24",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9ESV0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ESV0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9ESV0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ESV0"
}
]
}
]
},
{
"uniprot_ac": "Q9GQN5",
"gene_name": "XNP",
"activity": [
{
"ec_number": "3.6.1.3",
"activity": "",
"evidence": [
{
"id": "Q9GQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9GQN5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9GQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9GQN5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9GQN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9GQN5"
}
]
}
]
},
{
"uniprot_ac": "Q9GZR7",
"gene_name": "DDX24",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9GZR7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9GZR7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9GZR7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9GZR7"
}
]
}
]
},
{
"uniprot_ac": "Q9H078",
"gene_name": "CLPB",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q9H078",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H078"
}
]
}
]
},
{
"uniprot_ac": "Q9H0S4",
"gene_name": "DDX47",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H0S4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0S4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9H0S4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0S4"
}
]
}
]
},
{
"uniprot_ac": "Q9H2H8",
"gene_name": "PPIL3",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q9H2H8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2H8"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q9H2H8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2H8"
}
]
}
]
},
{
"uniprot_ac": "Q9H2U1",
"gene_name": "DHX36",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H2U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2U1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H2U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2U1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9H2U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2U1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9H2U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2U1"
}
]
}
]
},
{
"uniprot_ac": "Q9H4L7",
"gene_name": "SMARCAD1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H4L7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4L7"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9H4L7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4L7"
}
]
}
]
},
{
"uniprot_ac": "Q9H5Z1",
"gene_name": "DHX35",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H5Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H5Z1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9H5Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H5Z1"
}
]
}
]
},
{
"uniprot_ac": "Q9H611",
"gene_name": "PIF1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H611",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H611"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9H611",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H611"
}
]
}
]
},
{
"uniprot_ac": "Q9H6R0",
"gene_name": "DHX33",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H6R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H6R0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9H6R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H6R0"
}
]
}
]
},
{
"uniprot_ac": "Q9H6S0",
"gene_name": "YTHDC2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H6S0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H6S0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9H6S0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H6S0"
}
]
}
]
},
{
"uniprot_ac": "Q9H8H2",
"gene_name": "DDX31",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9H8H2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H8H2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9H8H2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H8H2"
}
]
}
]
},
{
"uniprot_ac": "Q9H8K7",
"gene_name": "PAAT",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q9H8K7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H8K7"
}
]
}
]
},
{
"uniprot_ac": "Q9HCE1",
"gene_name": "MOV10",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9HCE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCE1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9HCE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCE1"
}
]
}
]
},
{
"uniprot_ac": "Q9HCK8",
"gene_name": "CHD8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9HCK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCK8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9HCK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCK8"
}
]
}
]
},
{
"uniprot_ac": "Q9I7M8",
"gene_name": "Ku80",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9I7M8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9I7M8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9I7M8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9I7M8"
}
]
}
]
},
{
"uniprot_ac": "Q9JIK5",
"gene_name": "Ddx21",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9JIK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIK5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9JIK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIK5"
}
]
}
]
},
{
"uniprot_ac": "Q9JIX5",
"gene_name": "Chd8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9JIX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIX5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9JIX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIX5"
}
]
}
]
},
{
"uniprot_ac": "Q9JJY4",
"gene_name": "Ddx20",
"activity": [
{
"ec_number": "3.6.1.15",
"activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q9JJY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJY4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9JJY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJY4"
}
]
},
{
"ec_number": "3.6.1.15",
"activity": "",
"evidence": [
{
"id": "Q9JJY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJY4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9JJY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJY4"
}
]
}
]
},
{
"uniprot_ac": "Q9NQI0",
"gene_name": "DDX4",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NQI0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQI0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NQI0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQI0"
}
]
}
]
},
{
"uniprot_ac": "Q9NR30",
"gene_name": "DDX21",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NR30",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NR30"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NR30",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NR30"
}
]
}
]
},
{
"uniprot_ac": "Q9NUL7",
"gene_name": "DDX28",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NUL7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NUL7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NUL7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NUL7"
}
]
}
]
},
{
"uniprot_ac": "Q9NUU7",
"gene_name": "DDX19A",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NUU7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NUU7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NUU7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NUU7"
}
]
}
]
},
{
"uniprot_ac": "Q9NVP1",
"gene_name": "DDX18",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NVP1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NVP1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NVP1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NVP1"
}
]
}
]
},
{
"uniprot_ac": "Q9NW38",
"gene_name": "FANCL",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9NW38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NW38"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9NW38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NW38"
}
]
}
]
},
{
"uniprot_ac": "Q9NX74",
"gene_name": "DUS2",
"activity": [
{
"ec_number": "1.3.1.91",
"activity": "5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA.",
"evidence": [
{
"id": "Q9NX74",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NX74"
}
]
},
{
"ec_number": "1.3.1.91",
"activity": "",
"evidence": [
{
"id": "Q9NX74",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NX74"
}
]
}
]
},
{
"uniprot_ac": "Q9NXL9",
"gene_name": "MCM9",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NXL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NXL9"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9NXL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NXL9"
}
]
}
]
},
{
"uniprot_ac": "Q9NXZ2",
"gene_name": "DDX43",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NXZ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NXZ2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NXZ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NXZ2"
}
]
}
]
},
{
"uniprot_ac": "Q9NY93",
"gene_name": "DDX56",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NY93",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NY93"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9NY93",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NY93"
}
]
}
]
},
{
"uniprot_ac": "Q9NYA1",
"gene_name": "SPHK1",
"activity": [
{
"ec_number": "2.7.1.91",
"activity": "a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+).",
"evidence": [
{
"id": "Q9NYA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYA1"
}
]
},
{
"ec_number": "2.3.1.-",
"activity": "",
"evidence": [
{
"id": "Q9NYA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYA1"
}
]
},
{
"ec_number": "2.7.1.91",
"activity": "",
"evidence": [
{
"id": "Q9NYA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYA1"
}
]
}
]
},
{
"uniprot_ac": "Q9NZ71",
"gene_name": "RTEL1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9NZ71",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NZ71"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9NZ71",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NZ71"
}
]
}
]
},
{
"uniprot_ac": "Q9P0J7",
"gene_name": "KCMF1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9P0J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P0J7"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9P0J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P0J7"
}
]
}
]
},
{
"uniprot_ac": "Q9P2D1",
"gene_name": "CHD7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9P2D1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P2D1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9P2D1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P2D1"
}
]
}
]
},
{
"uniprot_ac": "Q9QUL6",
"gene_name": "Nsf",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9QUL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QUL6"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q9QUL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QUL6"
}
]
}
]
},
{
"uniprot_ac": "Q9QY15",
"gene_name": "Ddx25",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9QY15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY15"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9QY15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY15"
}
]
}
]
},
{
"uniprot_ac": "Q9QY16",
"gene_name": "Ddx25",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9QY16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY16"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9QY16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY16"
}
]
}
]
},
{
"uniprot_ac": "Q9UBN7",
"gene_name": "HDAC6",
"activity": [
{
"ec_number": "3.5.1.98",
"activity": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].",
"evidence": [
{
"id": "Q9UBN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBN7"
}
]
},
{
"ec_number": "3.5.1.98",
"activity": "",
"evidence": [
{
"id": "Q9UBN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBN7"
}
]
},
{
"ec_number": "3.5.1.-",
"activity": "",
"evidence": [
{
"id": "Q9UBN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBN7"
}
]
}
]
},
{
"uniprot_ac": "Q9UBR2",
"gene_name": "CTSZ",
"activity": [
{
"ec_number": "3.4.18.1",
"activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.",
"evidence": [
{
"id": "Q9UBR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBR2"
}
]
},
{
"ec_number": "3.4.18.1",
"activity": "",
"evidence": [
{
"id": "Q9UBR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBR2"
}
]
}
]
},
{
"uniprot_ac": "Q9UHI6",
"gene_name": "DDX20",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UHI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHI6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9UHI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHI6"
}
]
},
{
"ec_number": "3.6.1.15",
"activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UHI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHI6"
}
]
},
{
"ec_number": "3.6.1.15",
"activity": "",
"evidence": [
{
"id": "Q9UHI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHI6"
}
]
}
]
},
{
"uniprot_ac": "Q9UHL0",
"gene_name": "DDX25",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UHL0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHL0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9UHL0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHL0"
}
]
}
]
},
{
"uniprot_ac": "Q9UJA3",
"gene_name": "MCM8",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UJA3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UJA3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9UJA3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UJA3"
}
]
}
]
},
{
"uniprot_ac": "Q9UJV9",
"gene_name": "DDX41",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UJV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UJV9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9UJV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UJV9"
}
]
}
]
},
{
"uniprot_ac": "Q9ULG1",
"gene_name": "INO80",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9ULG1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ULG1"
}
]
}
]
},
{
"uniprot_ac": "Q9UMR2",
"gene_name": "DDX19B",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UMR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UMR2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9UMR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UMR2"
}
]
}
]
},
{
"uniprot_ac": "Q9UMS4",
"gene_name": "PRPF19",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9UMS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UMS4"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q9UMS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UMS4"
}
]
}
]
},
{
"uniprot_ac": "Q9UN37",
"gene_name": "VPS4A",
"activity": [
{
"ec_number": "3.6.4.6",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UN37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UN37"
}
]
},
{
"ec_number": "3.6.4.6",
"activity": "",
"evidence": [
{
"id": "Q9UN37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UN37"
}
]
}
]
},
{
"uniprot_ac": "Q9UNP9",
"gene_name": "PPIE",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q9UNP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UNP9"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q9UNP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UNP9"
}
]
}
]
},
{
"uniprot_ac": "Q9UQ16",
"gene_name": "DNM3",
"activity": [
{
"ec_number": "3.6.5.5",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9UQ16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQ16"
}
]
},
{
"ec_number": "3.6.5.5",
"activity": "",
"evidence": [
{
"id": "Q9UQ16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQ16"
}
]
}
]
},
{
"uniprot_ac": "Q9V3C0",
"gene_name": "abs",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9V3C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3C0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9V3C0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3C0"
}
]
}
]
},
{
"uniprot_ac": "Q9V3C4",
"gene_name": "Gem3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9V3C4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3C4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9V3C4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3C4"
}
]
}
]
},
{
"uniprot_ac": "Q9V3K3",
"gene_name": "rept",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9V3K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3K3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9V3K3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3K3"
}
]
}
]
},
{
"uniprot_ac": "Q9V433",
"gene_name": "RecQ5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9V433",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V433"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9V433",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V433"
}
]
}
]
},
{
"uniprot_ac": "Q9V461",
"gene_name": "Mcm6",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9V461",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V461"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9V461",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V461"
}
]
}
]
},
{
"uniprot_ac": "Q9VD51",
"gene_name": "pit",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VD51",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VD51"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VD51",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VD51"
}
]
}
]
},
{
"uniprot_ac": "Q9VDA0",
"gene_name": "Fancm",
"activity": [
{
"ec_number": "5.6.2.4",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.",
"evidence": [
{
"id": "Q9VDA0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VDA0"
}
]
},
{
"ec_number": "5.6.2.4",
"activity": "",
"evidence": [
{
"id": "Q9VDA0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VDA0"
}
]
}
]
},
{
"uniprot_ac": "Q9VDY1",
"gene_name": "Ino80",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9VDY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VDY1"
}
]
}
]
},
{
"uniprot_ac": "Q9VF26",
"gene_name": "spn-E",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VF26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VF26"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VF26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VF26"
}
]
}
]
},
{
"uniprot_ac": "Q9VGI8",
"gene_name": "Blm",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VGI8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VGI8"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VGI8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VGI8"
}
]
}
]
},
{
"uniprot_ac": "Q9VGW6",
"gene_name": "Mcm5",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VGW6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VGW6"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VGW6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VGW6"
}
]
}
]
},
{
"uniprot_ac": "Q9VH07",
"gene_name": "pont",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VH07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VH07"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VH07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VH07"
}
]
}
]
},
{
"uniprot_ac": "Q9VHP0",
"gene_name": "bel",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VHP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VHP0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VHP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VHP0"
}
]
}
]
},
{
"uniprot_ac": "Q9VHS8",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VHS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VHS8"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VHS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VHS8"
}
]
}
]
},
{
"uniprot_ac": "Q9VHU1",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VHU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VHU1"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VHU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VHU1"
}
]
}
]
},
{
"uniprot_ac": "Q9VIF6",
"gene_name": "pths",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VIF6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VIF6"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VIF6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VIF6"
}
]
}
]
},
{
"uniprot_ac": "Q9VIZ3",
"gene_name": "l(2)37Cb",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VIZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VIZ3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VIZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VIZ3"
}
]
}
]
},
{
"uniprot_ac": "Q9VJ74",
"gene_name": "Dmel\\CG10333",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VJ74",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VJ74"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VJ74",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VJ74"
}
]
}
]
},
{
"uniprot_ac": "Q9VL25",
"gene_name": "ath",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VL25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL25"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VL25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL25"
}
]
}
]
},
{
"uniprot_ac": "Q9VL52",
"gene_name": "SoYb",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VL52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL52"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VL52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL52"
}
]
}
]
},
{
"uniprot_ac": "Q9VL72",
"gene_name": "Etl1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VL72",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL72"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VL72",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL72"
}
]
}
]
},
{
"uniprot_ac": "Q9VL76",
"gene_name": "mtDNA-helicase",
"activity": [
{
"ec_number": "5.6.2.3",
"activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.",
"evidence": [
{
"id": "Q9VL76",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL76"
}
]
},
{
"ec_number": "5.6.2.3",
"activity": "",
"evidence": [
{
"id": "Q9VL76",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL76"
}
]
}
]
},
{
"uniprot_ac": "Q9VN03",
"gene_name": "Suv3",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VN03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VN03"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VN03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VN03"
}
]
}
]
},
{
"uniprot_ac": "Q9VNP5",
"gene_name": "BoYb",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VNP5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VNP5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VNP5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VNP5"
}
]
}
]
},
{
"uniprot_ac": "Q9VNV3",
"gene_name": "Ddx1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VNV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VNV3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VNV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VNV3"
}
]
}
]
},
{
"uniprot_ac": "Q9VPT3",
"gene_name": "Dbp21E2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VPT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VPT3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VPT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VPT3"
}
]
}
]
},
{
"uniprot_ac": "Q9VQN8",
"gene_name": "Fign",
"activity": [
{
"ec_number": "3.-.-.-",
"activity": "",
"evidence": [
{
"id": "Q9VQN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VQN8"
}
]
},
{
"ec_number": "5.6.1.1",
"activity": "n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.",
"evidence": [
{
"id": "Q9VQN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VQN8"
}
]
},
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "Q9VQN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VQN8"
}
]
}
]
},
{
"uniprot_ac": "Q9VQR3",
"gene_name": "Pif1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VQR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VQR3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VQR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VQR3"
}
]
}
]
},
{
"uniprot_ac": "Q9VRI0",
"gene_name": "Ddx56",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VRI0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VRI0"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VRI0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VRI0"
}
]
}
]
},
{
"uniprot_ac": "Q9VSE2",
"gene_name": "mus301",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VSE2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VSE2"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VSE2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VSE2"
}
]
}
]
},
{
"uniprot_ac": "Q9VUV9",
"gene_name": "Brr2",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VUV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VUV9"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VUV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VUV9"
}
]
}
]
},
{
"uniprot_ac": "Q9VVK8",
"gene_name": "ais",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VVK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VVK8"
}
]
}
]
},
{
"uniprot_ac": "Q9VX34",
"gene_name": "cg5800",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VX34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VX34"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VX34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VX34"
}
]
}
]
},
{
"uniprot_ac": "Q9VY54",
"gene_name": "Prp16",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VY54",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VY54"
}
]
}
]
},
{
"uniprot_ac": "Q9VYS3",
"gene_name": "Upf1",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VYS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VYS3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9VYS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VYS3"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9VYS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VYS3"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9VYS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VYS3"
}
]
}
]
},
{
"uniprot_ac": "Q9W3Y5",
"gene_name": "",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9W3Y5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W3Y5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9W3Y5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W3Y5"
}
]
}
]
},
{
"uniprot_ac": "Q9W484",
"gene_name": "Rtel1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9W484",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W484"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9W484",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W484"
}
]
}
]
},
{
"uniprot_ac": "Q9W4W2",
"gene_name": "fs(1)Yb",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9W4W2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W4W2"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9W4W2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W4W2"
}
]
}
]
},
{
"uniprot_ac": "Q9WTM5",
"gene_name": "Ruvbl2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9WTM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTM5"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9WTM5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTM5"
}
]
}
]
},
{
"uniprot_ac": "Q9WTT2",
"gene_name": "Clpb",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q9WTT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTT2"
}
]
}
]
},
{
"uniprot_ac": "Q9XYU0",
"gene_name": "Mcm7",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9XYU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9XYU0"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9XYU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9XYU0"
}
]
}
]
},
{
"uniprot_ac": "Q9XYU1",
"gene_name": "Mcm3",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9XYU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9XYU1"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9XYU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9XYU1"
}
]
}
]
},
{
"uniprot_ac": "Q9Y230",
"gene_name": "RUVBL2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Y230",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y230"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9Y230",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y230"
}
]
}
]
},
{
"uniprot_ac": "Q9Y265",
"gene_name": "RUVBL1",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Y265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y265"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9Y265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y265"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2R4",
"gene_name": "DDX52",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Y2R4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2R4"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9Y2R4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2R4"
}
]
}
]
},
{
"uniprot_ac": "Q9Y315",
"gene_name": "DERA",
"activity": [
{
"ec_number": "4.1.2.4",
"activity": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate.",
"evidence": [
{
"id": "Q9Y315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y315"
}
]
},
{
"ec_number": "4.1.2.4",
"activity": "",
"evidence": [
{
"id": "Q9Y315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y315"
}
]
}
]
},
{
"uniprot_ac": "Q9Y3C6",
"gene_name": "PPIL1",
"activity": [
{
"ec_number": "5.2.1.8",
"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).",
"evidence": [
{
"id": "Q9Y3C6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y3C6"
}
]
},
{
"ec_number": "5.2.1.8",
"activity": "",
"evidence": [
{
"id": "Q9Y3C6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y3C6"
}
]
}
]
},
{
"uniprot_ac": "Q9Y4B4",
"gene_name": "RAD54L2",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Y4B4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y4B4"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9Y4B4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y4B4"
}
]
}
]
},
{
"uniprot_ac": "Q9Y6V7",
"gene_name": "DDX49",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Y6V7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6V7"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9Y6V7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6V7"
}
]
}
]
},
{
"uniprot_ac": "Q9Y6X9",
"gene_name": "MORC2",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q9Y6X9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6X9"
}
]
}
]
},
{
"uniprot_ac": "Q9Z129",
"gene_name": "Recql",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Z129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z129"
}
]
},
{
"ec_number": "3.6.4.12",
"activity": "",
"evidence": [
{
"id": "Q9Z129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z129"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1N5",
"gene_name": "Ddx39b",
"activity": [
{
"ec_number": "3.6.4.13",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q9Z1N5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1N5"
}
]
},
{
"ec_number": "3.6.4.13",
"activity": "",
"evidence": [
{
"id": "Q9Z1N5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1N5"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [],
"cluster_types": [
{
"name": "isoformset.uniprotkb",
"label": "Isoforms"
},
{
"name": "homologset.oma",
"label": "OMA Homologs"
},
{
"name": "homologset.mgi",
"label": "MGI Homologs"
}
],
"sequence_features": {
"n_linked_sites": [
35
],
"o_linked_sites": [
64,
313,
430,
502
],
"snv_sites": [
98,
275,
550
],
"glycation_sites": [],
"phosphorylation_sites": [
41,
107,
153,
254,
329,
362,
385,
397,
462,
477,
541,
611,
633,
637,
638,
641
],
"sequon_annotation_sites": [
{
"start_pos": 151,
"end_pos": 153
},
{
"start_pos": 35,
"end_pos": 37
},
{
"start_pos": 360,
"end_pos": 362
},
{
"start_pos": 417,
"end_pos": 419
},
{
"start_pos": 487,
"end_pos": 489
},
{
"start_pos": 584,
"end_pos": 586
}
]
},
"section_stats": [
{
"table_id": "glycosylation",
"table_stats": [
{
"field": "total",
"count": 5
},
{
"field": "total_sites",
"count": 5
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 1
},
{
"field": "o_linked_glycans",
"count": 1
},
{
"field": "o_linked_glycan_sites",
"count": 4
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported",
"table_stats": [
{
"field": "total",
"count": 1
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 1
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported_with_glycan",
"table_stats": [
{
"field": "total",
"count": 4
},
{
"field": "total_sites",
"count": 4
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 1
},
{
"field": "o_linked_glycan_sites",
"count": 4
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_predicted",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_automatic_literature_mining",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "phosphorylation",
"table_stats": [
{
"field": "total",
"count": 16
},
{
"field": "total_sites",
"count": 16
}
],
"sort_fields": [
"start_pos",
"end_pos",
"kinase_uniprot_canonical_ac",
"kinase_gene_name",
"residue",
"comment",
"site_lbl"
]
},
{
"table_id": "snv",
"table_stats": [
{
"field": "total",
"count": 3
},
{
"field": "total_sites",
"count": 3
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl"
]
},
{
"table_id": "snv_disease",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "snv_non_disease",
"table_stats": [
{
"field": "total",
"count": 3
},
{
"field": "total_sites",
"count": 3
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl"
]
},
{
"table_id": "publication",
"table_stats": [
{
"field": "total",
"count": 674
}
],
"sort_fields": [
"title",
"journal",
"date",
"authors"
]
}
]
}