{ "uniprot_canonical_ac": "P11137-1", "uniprot_ac": "P11137", "uniprot_id": "MTAP2_HUMAN", "mass": { "chemical_mass": 199526.0, "monoisotopic_mass": 199526.0 }, "refseq": { "ac": "NP_001034627", "name": "microtubule-associated protein 2 isoform 5", "summary": "This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" }, "gene_names": [ { "name": "MAP2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11137", "id": "P11137" }, { "name": "MAP-2; MAP2A; MAP2B; MAP2C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627", "id": "NP_001034627" }, { "name": "MAP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627", "id": "NP_001034627" }, { "name": "hCG_1776452", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P11137", "id": "P11137" } ], "protein_names": [ { "name": "Microtubule-associated protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11137" }, { "name": "MAP-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11137" }, { "name": "microtubule-associated protein 2 isoform 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627", "id": "NP_001034627" } ], "function": [ { "annotation": "Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" }, { "database": "PubMed", "id": "37702880", "url": "https://glygen.org/publication/PubMed/37702880" } ] }, { "annotation": "Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" }, { "database": "PubMed", "id": "37258650", "url": "https://glygen.org/publication/PubMed/37258650" } ] }, { "annotation": "MAP2 caps tau fibrils and inhibits aggregation.", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" }, { "database": "PubMed", "id": "37286038", "url": "https://glygen.org/publication/PubMed/37286038" } ] }, { "annotation": "Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" }, { "database": "PubMed", "id": "35229233", "url": "https://glygen.org/publication/PubMed/35229233" } ] }, { "annotation": "Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" }, { "database": "PubMed", "id": "35987383", "url": "https://glygen.org/publication/PubMed/35987383" } ] }, { "annotation": "The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137#function" } ] }, { "annotation": "This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1353729149", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1353729149" }, { "id": "rs1353729149", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1353729149#frequency_tab" }, { "id": "rs1353729149", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1353729149" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1049, "end_pos": 1049, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIS->NIS).", "chr_id": "2", "chr_pos": "209695317", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K1049", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1170252000", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1170252000" }, { "id": "rs1170252000", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1170252000#frequency_tab" }, { "id": "rs1170252000", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1170252000" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1082, "end_pos": 1082, "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->F).", "chr_id": "2", "chr_pos": "209695415", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1082", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1222327902", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1222327902" }, { "id": "rs1222327902", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1222327902" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 118, "end_pos": 118, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DQT->NQT).", "chr_id": "2", "chr_pos": "209678661", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D118", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P11137", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11137" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1224, "end_pos": 1224, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "2", "chr_pos": "209695841", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T1224", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P11137", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11137" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "common_name": "Human" } ], "gene": [ { "name": "MAP2", "url": "https://www.uniprot.org/uniprot/P11137", "locus": { "chromosome": "2", "start_pos": 209734147, "end_pos": 209424047, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000078018", "url": "https://www.ensembl.org/id/ENSG00000078018" } ] } } ], "crossref": [ { "id": "ENSG00000078018", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078018", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P11137", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11137", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "CHEMBL2390810", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2390810", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "MAP2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MAP2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "4133", "url": "https://www.ncbi.nlm.nih.gov/gene/4133", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6839", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6839", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P11137", "url": "https://www.ebi.ac.uk/intact/interactors/id:P11137*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027324", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4133", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4133", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "157130", "url": "http://www.omim.org/entry/157130", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P11137", "url": "https://www.nextprot.org/entry/NX_P11137", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P11137", "url": "https://oglcnac.org/atlas/detail/P11137", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P11137", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11137", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "FDQERKV", "url": "https://omabrowser.org/oma/group/FDQERKV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5406159at2759", "url": "http://www.orthodb.org/?query=5406159at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11501", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11501", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11501:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11501:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00418", "url": "http://pfam.xfam.org/family/PF00418", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08377", "url": "http://pfam.xfam.org/family/PF08377", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10522", "url": "http://pfam.xfam.org/family/PF10522", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P11137", "url": "https://pharos.nih.gov/targets/P11137", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P11137", "url": "http://purl.obolibrary.org/obo/PR_P11137", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A024R3Z1", "url": "https://www.uniprot.org/uniprot/A0A024R3Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A024R3Z1-1", "url": "https://www.uniprot.org/uniprot/A0A024R3Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A669KB77", "url": "https://www.uniprot.org/uniprot/A0A669KB77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A669KB77-1", "url": "https://www.uniprot.org/uniprot/A0A669KB77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8MZ31", "url": "https://www.uniprot.org/uniprot/A8MZ31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8MZ31-1", "url": "https://www.uniprot.org/uniprot/A8MZ31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EV03", "url": "https://www.uniprot.org/uniprot/E7EV03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EV03-1", "url": "https://www.uniprot.org/uniprot/E7EV03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BZB9", "url": "https://www.uniprot.org/uniprot/H7BZB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BZB9-1", "url": "https://www.uniprot.org/uniprot/H7BZB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11137-1", "url": "https://www.uniprot.org/uniprot/P11137-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11137-2", "url": "https://www.uniprot.org/uniprot/P11137-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11137-3", "url": "https://www.uniprot.org/uniprot/P11137-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11137-4", "url": "https://www.uniprot.org/uniprot/P11137-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1827, "header": "sp|P11137-1|MTAP2_HUMAN Isoform 1 of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4 CANONICAL=P11137-1" }, "isoforms": [ { "isoform_ac": "A0A024R3Z1-1", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVRILNKKIDFSKVQSRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1858, "header": "tr|A0A024R3Z1-1|MTAP2_HUMAN Computationally mapped isoform of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=1 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209730394, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704357.1", "url": "https://www.ensembl.org/id/ENST00000704357.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515868.1", "url": "https://www.ensembl.org/id/ENSP00000515868.1" } ] } }, { "isoform_ac": "A0A669KB77-1", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDEGAEDQVGPLHRFPSHEPATSGERRGLLAPSISVSVPDDDPYNSDEEYYEHPLFSSERTTSSVLPSVTAQSAEAHLGQEKEEETLESRMAEEEKPAALPEKECGAAKSSDQPKGLSKGQMESSAEAQIVPEESAPAGAPHEKSVKEVKEVSPEVKTPSSAGEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1990, "header": "tr|A0A669KB77-1|MTAP2_HUMAN Computationally mapped isoform of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=1 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209730394, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000673860.1", "url": "https://www.ensembl.org/id/ENST00000673860.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000501117.1", "url": "https://www.ensembl.org/id/ENSP00000501117.1" } ] } }, { "isoform_ac": "A8MZ31-1", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVL", "length": 106, "header": "tr|A8MZ31-1|MTAP2_HUMAN Computationally mapped isoform of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=1 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209678627, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000392193.5", "url": "https://www.ensembl.org/id/ENST00000392193.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000376031.1", "url": "https://www.ensembl.org/id/ENSP00000376031.1" } ] } }, { "isoform_ac": "E7EV03-1", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEEEETLESRMAEEEKPAALPEKECGAAKSSDQPKGLSKGQMESSAEAQIVPEESAPAGAPHEKSVKEVKEVSPEVKTPSSAGEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQK", "length": 567, "header": "tr|E7EV03-1|MTAP2_HUMAN Computationally mapped isoform of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=1 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209693625, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445941.5", "url": "https://www.ensembl.org/id/ENST00000445941.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000409969.1", "url": "https://www.ensembl.org/id/ENSP00000409969.1" } ] } }, { "isoform_ac": "H7BZB9-1", "url": "", "sequence": { "sequence": "INGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEAAGGESALAPSVFKQAKDKVSGVHVQACYKGILRDAENSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSL", "length": 208, "header": "tr|H7BZB9-1|H7BZB9_HUMAN Computationally mapped isoform of Microtubule associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=1 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209705690, "end_pos": 209653393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452717.1", "url": "https://www.ensembl.org/id/ENST00000452717.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000388824.1", "url": "https://www.ensembl.org/id/ENSP00000388824.1" } ] } }, { "isoform_ac": "P11137-1", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1827, "header": "sp|P11137-1|MTAP2_HUMAN Isoform 1 of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209730394, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000360351.8", "url": "https://www.ensembl.org/id/ENST00000360351.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000353508.4", "url": "https://www.ensembl.org/id/ENSP00000353508.4" } ] } }, { "isoform_ac": "P11137-2", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 471, "header": "sp|P11137-2|MTAP2_HUMAN Isoform 2 of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209730394, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000361559.8", "url": "https://www.ensembl.org/id/ENST00000361559.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000355290.4", "url": "https://www.ensembl.org/id/ENSP00000355290.4" } ] } }, { "isoform_ac": "P11137-3", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1823, "header": "sp|P11137-3|MTAP2_HUMAN Isoform 3 of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209730394, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000447185.5", "url": "https://www.ensembl.org/id/ENST00000447185.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000392164.1", "url": "https://www.ensembl.org/id/ENSP00000392164.1" } ] } }, { "isoform_ac": "P11137-4", "url": "", "sequence": { "sequence": "MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEAAGGESALAPSVFKQAKDKVSNSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVRILNKKIDFSKVQSRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 559, "header": "sp|P11137-4|MTAP2_HUMAN Isoform 4 of Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4 CANONICAL=P11137-1" }, "locus": { "chromosome": "2", "start_pos": 209730394, "end_pos": 209653171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000199940.10", "url": "https://www.ensembl.org/id/ENST00000199940.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000199940.6", "url": "https://www.ensembl.org/id/ENSP00000199940.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1082, "start_aa": "Ser", "end_pos": 1082, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1082", "evidence": [ { "id": "P11137", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11137" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "P11137", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P11137" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": 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efficient phosphoproteomic analysis.", "journal": "J. Proteome Res.", "date": "2008", "authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" }, { "database": "iPTMnet", "id": "P11137", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137" } ], "reference": [ { "type": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ] }, { "title": "Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry.", "journal": "Journal of proteome research", "date": "2008", "authors": "Xia Q, Cheng D, Duong DM, Gearing M, Lah JJ, Levey AI, Peng J", "evidence": [ { "database": "iPTMnet", "id": "P11137-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137-1" } ], "reference": [ { "type": "PubMed", "id": "18510355", "url": "https://glygen.org/publication/PubMed/18510355" } ] }, { "title": "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.", "journal": "Journal of proteome research", "date": "2008", "authors": "Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ", "evidence": [ { "database": "iPTMnet", "id": "P11137-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137-1" } ], "reference": [ { "type": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "P11137-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer.", "journal": "Analytical chemistry", "date": "2010", "authors": "Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "P11137-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137-1" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "P11137-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" }, { "database": "iPTMnet", "id": "P11137", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.", "journal": "Nature genetics", "date": "2013", "authors": "Dulak AM, Stojanov P, Peng S, Lawrence MS, Fox C, Stewart C, Bandla S, Imamura Y, Schumacher SE, Shefler E, McKenna A, Carter SL, Cibulskis K, Sivachenko A, Saksena G, Voet D, Ramos AH, Auclair D, Thompson K, Sougnez C, Onofrio RC, Guiducci C, Beroukhim R, Zhou Z, Lin L, Lin J, Reddy R, Chang A, Landrenau R, Pennathur A, Ogino S, Luketich JD, Golub TR, Gabriel SB, Lander ES, Beer DG, Godfrey TE, Getz G, Bass AJ", "evidence": [ { "database": "dbSNP", "id": "rs1583656583", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1583656583" }, { "database": "dbSNP", "id": "rs770938168", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs770938168" } ], "reference": [ { "type": "PubMed", "id": "23525077", "url": "https://glygen.org/publication/PubMed/23525077" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" }, { "database": "iPTMnet", "id": "P11137", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles.", "journal": "J. Neurochem.", "date": "1988", "authors": "Kosik K S, Orecchio L D, Bakalis S, Duffy L, Neve R L", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "reference": [ { "type": "PubMed", "id": "2455776", "url": "https://glygen.org/publication/PubMed/2455776" } ] }, { "title": "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles.", "journal": "J. Neurosci. Res.", "date": "1989", "authors": "Dammerman M, Yen S H, Shafit-Zagardo B", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "reference": [ { "type": "PubMed", "id": "2481044", "url": "https://glygen.org/publication/PubMed/2481044" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11137", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11137" }, { "database": "O-GlcNAc Atlas", "id": "P11137", "url": "https://oglcnac.org/atlas/detail/P11137" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11137", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11137" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.", "journal": "Am. J. Hum. Genet.", "date": "2021", "authors": "Jeanne M, Demory H, Moutal A, Vuillaume ML, Blesson S, Thepault RA, Marouillat S, Halewa J, Maas SM, Motazacker MM, Mancini GMS, van Slegtenhorst MA, Andreou A, Cox H, Vogt J, Laufman J, Kostandyan N, Babikyan D, Hancarova M, Bendova S, Sedlacek Z, Aldinger KA, Sherr EH, Argilli E, England EM, Audebert-Bellanger S, Bonneau D, Colin E, Denomme-Pichon AS, Gilbert-Dussardier B, Isidor B, Kury S, Odent S, Redon R, Khanna R, Dobyns WB, Bezieau S, Honnorat J, Lohkamp B, Toutain A, Laumonnier F", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "reference": [ { "type": "PubMed", "id": "33894126", "url": "https://glygen.org/publication/PubMed/33894126" } ] }, { "title": "Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.", "journal": "Neurocritical care", "date": "2022", "authors": "Svingos AM, Robicsek SA, Hayes RL, Wang KK, Robertson CS, Brophy GM, Papa L, Gabrielli A, Hannay HJ, Bauer RM, Heaton SC", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" } ], "reference": [ { "type": "PubMed", "id": "35229233", "url": "https://glygen.org/publication/PubMed/35229233" } ] }, { "title": "Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.", "journal": "The Journal of biological chemistry", "date": "2022-10", "authors": "Plucarov\u00e1 Jitka, Jansen S\u00e9verine, Narasimhan Subhash, Lan\u00edkov\u00e1 Alice, Lewitzky Marc, Feller Stephan M, \u017d\u00eddek Luk\u00e1\u0161", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" } ], "reference": [ { "type": "PubMed", "id": "35987383", "url": "https://glygen.org/publication/PubMed/35987383" } ] }, { "title": "Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.", "journal": "Scientific reports", "date": "2023-05-31", "authors": "Nishida Kohei, Matsumura Kosuke, Tamura Miki, Nakamichi Takuto, Shimamori Keiya, Kuragano Masahiro, Kabir Arif Md Rashedul, Kakugo Akira, Kotani Susumu, Nishishita Naoki, Tokuraku Kiyotaka", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" } ], "reference": [ { "type": "PubMed", "id": "37258650", "url": "https://glygen.org/publication/PubMed/37258650" } ] }, { "title": "MAP2 caps tau fibrils and inhibits aggregation.", "journal": "The Journal of biological chemistry", "date": "2023-07", "authors": "Holden Michael R, Krzesinski Brad J, Weismiller Hilary A, Shady Justin R, Margittai Martin", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" } ], "reference": [ { "type": "PubMed", "id": "37286038", "url": "https://glygen.org/publication/PubMed/37286038" } ] }, { "title": "Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2023-10", "authors": "DeGiosio R A, Needham P G, Andrews O A, Tristan H, Grubisha M J, Brodsky J L, Camacho C, Sweet R A", "evidence": [ { "database": "RefSeq", "id": "NP_001034627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034627" } ], "reference": [ { "type": "PubMed", "id": "37702880", "url": "https://glygen.org/publication/PubMed/37702880" } ] }, { "title": "Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro.", "journal": "European journal of cell biology", "date": "1994", "authors": "Berling B, Wille H, Roll B, Mandelkow EM, Garner C, Mandelkow E", "evidence": [ { "database": "iPTMnet", "id": "P11137", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137" } ], "reference": [ { "type": "PubMed", "id": "7525290", "url": "https://glygen.org/publication/PubMed/7525290" } ] }, { "title": "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2).", "journal": "Gene", "date": "1993", "authors": "Albala J S, Kalcheva N, Shafit-Zagardo B", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "reference": [ { "type": "PubMed", "id": "8294038", "url": "https://glygen.org/publication/PubMed/8294038" } ] }, { "title": "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Illenberger S, Drewes G, Trinczek B, Biernat J, Meyer HE, Olmsted JB, Mandelkow EM, Mandelkow E", "evidence": [ { "database": "iPTMnet", "id": "P11137-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11137-1" } ], "reference": [ { "type": "PubMed", "id": "8631898", "url": "https://glygen.org/publication/PubMed/8631898" } ] } ], "pathway": [ { "id": "hsa:4133", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4133", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P15146-1", "protein_name": "Microtubule-associated protein 2", "gene_name": "Map2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADERKDEGKAPHWTSASLTEAAAHPHSPEMKDQGGSGEGLSRSANGFPYREEEEGAFGEHGSQGTYSDTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQPAALPLAAEETVNLPPSPPPSPASEQTAALEEDLLTASKMEFPEQQKLPSSFAEPLDKEETEFKMQSKPGEDFEHAALVPQPDTSKTPQDKKDPQDMEGEKSPASPFAQTFGTNLEDIKQITEPSITVPSIGLSAEPLAPKDQKDWFIEMPVESKKDEWGLAAPISPGPLTPMREKDVLEDIPRWEGKQFDSPMPSPFHGGSFTLPLDTVKDERVTEGSQPFAPVFFQSDDKMSLQDTSGSATSKESSKDEEPQKDKADKVADVPVSEATTVLGDVHSPAVEGFVGENISGEEKGTTDQEKKETSTPSVQEPTLTETEPQTKLEETSKVSIEETVAKEEESLKLKDDKAGVIQTSTEQSFSKEDQKGQEQTIEALKQDSFPISLEQAVTDAAMATKTLEKVTSEPEAVSEKREIQGLFEEDIADKSKLEGAGSATVAEVEMPFYEDKSGMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSPKNQQDEKELLAKASQPSPPAHEAGYSTLAQSYTSDHPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKIPCFPIESKEEEDKTEQAKVTGGQTTQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEAVVAESSTGLPPVADDSQPVKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDSKEHAKESEEVGDKVELFGLGVTYEQTSAKELITTKETAPERAEKGLSSVPEVAEVETTTKADQGLDVAAKKDDQSPLDIKVSDFGQMASGMSVDAGKTIELKFEVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADSSIDEKAEVQMEFIQLPKEESTETPDIPAIPSDVTQPQPEAVVSEPAEVRGEEEEIEAEGEYDKLLFRSDTLQITDLLVPGSREEFVETCPGEHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQPEEERRPYPHDEELEVLMAAEAQAEPKDGSPDAPATPEKEEVPFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTEQLETIPKEERAEKEARRPSLEKHRKEKPFKTGRGRISTPERREVAKKEPSTVSRDEVRRKKAVYKKAELAKESEVQAHSPSRKLILKPAIKYTRPTHLSCVKRKTTATSGESAQAPSAFKQAKDKVTDGITKSPEKRSSLPRPSSILPPRRGVSGDREENSFSLNSSISSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPGTPKSGILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVRILNKKMDFSKVQSRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPSRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1861 }, "evidence": [ { "id": "45925721", "url": "http://www.informatics.jax.org/homology/45925721", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P20357-1", "protein_name": "Microtubule-associated protein 2", "gene_name": "Map2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADERKDEGKAPHWTSASLTEAAAHPHSPEMKDQGGAGEGLSRNANGFPYREEEEGAFGEHRSQGTYSDTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQPAALPLAAEETANLPPSPPPSPASEQTATVEEDLLTASKMEFPEQEKFPSSFAEPLDKGEMEFKMPSKPGEDFEHAALVPDTSKTPQDKKDLQGMEGEKLPPVPFAQTFGTNLEDRKQSTEPSIVMPSIGLSAEPPAPKEPKDWFIEMPTESKKDEWGLAAPISPGPLTPMREKDVLEDIPRWEGKQFDSPMPSPFHGGSFTLPLDTMKNERVSEGPRPFAPVFFQSDDKVSLQDPSALATSKESSKDEEPLKDKADKVADVSISEVTTLLGNVHSPVVEGYVGENISGEVKVTTDQEKKETSAPSVQEPTLTETEPQTKLDEKSTVSIEEAVAKKEESFKLRDDKTGVIQTSTEQSFSKEDQKGQEHTIDELKQDSFPISLEQAVTDAAMTSKTLGKVTSEPEAVSERREIQGLFEEKTADKNKLEGAGSATIAEVEMPFYEDKSGMSKYFETSALKEDMTRSTELGSDYYELSDSRGSAQESLDTISPKNQHDEKELQAKASQPSPPAQEAGYSTLAQSYTPDHPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKMPCFPIESKEEEDKAEQAKVTGGQTIQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEAMLAESSTSLPPVADESPVTVKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPTSADKSRLSREFDHDRKANDKLDTVLEKSEEHIDSKEHAKESEEMGGKVELFGLGITYDQASTKELITTKDTSPEKTEKGLSSVPEVAEVEPTTKADQGLDFAATKAEPSQLDIKVSDFGQMASGMNVDAGKAIELKFEVAQELTLSSEAPQEADSFMGVESGHIKEGGKVNETEVKEKVTKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADLSTDEKGEVQMEFIQLPKEESTETPDIPAIPSDVTQPQPEAIVSEPAEVPSEEEEIEAGGEYDKLLFRSDTLQISDLLVSESREEFVETCPGELKGVVESVVTIEDDFITVVQTTTDEGESGSHSVRFAAPAQPEEERRPRPHDEELEIEMAAEAQAEPKDGSPDAPATPEKEEVAFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTEQLETIPKEERAEKDARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLILKPAIKYTRPTHLSCVKRKTTAASGDLAQAPGAFKQAKDKVTDGISKSPEKRSSLPRPSSILPPRRGVSGDREENSFSLNSSISSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPGTPKSGILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPSRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL", "length": 1828 }, "evidence": [ { "id": "45925721", "url": "http://www.informatics.jax.org/homology/45925721", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" }, { "name": "tau protein binding", "id": "GO:0048156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048156", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" }, { "name": "dystroglycan binding", "id": "GO:0002162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002162", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 21, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P11137", "url": "https://www.uniprot.org/uniprot/P11137" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": 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