{ "uniprot_canonical_ac": "P10901-1", "uniprot_ac": "P10901", "uniprot_id": "FUCO_DICDI", "mass": { "chemical_mass": 52647.0, "monoisotopic_mass": 52647.0 }, "refseq": { "ac": "XP_644263", "name": "hypothetical protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_644263" }, "gene_names": [ { "name": "alfA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10901", "id": "P10901" }, { "name": "DDB_G0274391", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10901", "id": "P10901" }, { "name": "alfA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_644263", "id": "XP_644263" } ], "protein_names": [ { "name": "Alpha-L-fucosidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10901" }, { "name": "3.2.1.51", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10901" }, { "name": "Alpha-L-fucoside fucohydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10901" }, { "name": "hypothetical protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_644263", "id": "XP_644263" } ], "function": [ { "annotation": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "alfA", "url": "https://www.uniprot.org/uniprot/P10901", "locus": {} } ], "crossref": [ { "id": "3.2.1.51", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.51&UniProtAcc=P10901", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GH29", "url": "http://www.cazy.org/GH29.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0274391", "url": "http://dictybase.org/gene/DDB_G0274391", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8619691", "url": "https://www.ncbi.nlm.nih.gov/gene/8619691", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016286", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016286", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0274391", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0274391", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LPEHKWE", "url": "https://omabrowser.org/oma/group/LPEHKWE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10030", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10030", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10030:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10030:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01120", "url": "http://pfam.xfam.org/family/PF01120", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16757", "url": "http://pfam.xfam.org/family/PF16757", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10901", "url": "http://purl.obolibrary.org/obo/PR_P10901", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-975578", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-975578", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_644263", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_644263", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12288", "url": "https://www.rhea-db.org/rhea/12288", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10901-1", "url": "https://www.uniprot.org/uniprot/P10901-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMIIIFFILLILNLIKSQQYGPTWDQINSRPLPGWYDDVKFGIFIHFGIYSVPAFANGGYAEWYWWTLKNPSSDGGATQRYHEKEFGANFTYQDFVSRFDCRLFDANEWASIIEKSGAKYVVLTSKHHEGYTLWNSEQSWNWNSVETGPGIDIVGELTKSVKNMGLHMGLYHSLFEWFNPLYLADAETGKNPTTQVYVDEILMKQLKDIVTTYEPELIWADGDWMQLSNYWKSTEFLSWLYTNSSVKDTVIVNDRWGSECRDKNGGFYTGADHFNPYKLQSHKWENCATIGYSYGYDEYEQATDYQNATELIIDLVTTVACGGNFLLDVGPDAQGTIPNNMVDRLLEIGNWLSINSESIYGSSPWRVQNMTFNIWYTTNTTNGNVYAFVFELPDDGVLILSDPIGNNKTEATLLGLKGEKGVEVSLPIESTKPGITLNIPMVAPQDYPPYVYVFRLTDVE", "length": 461, "header": "sp|P10901-1|FUCO_DICDI Isoform 1 of Alpha-L-fucosidase OS=Dictyostelium discoideum OX=44689 GN=alfA PE=3 SV=1 CANONICAL=P10901-1" }, "isoforms": [ { "isoform_ac": "P10901-1", "url": "", "sequence": { "sequence": "MKMIIIFFILLILNLIKSQQYGPTWDQINSRPLPGWYDDVKFGIFIHFGIYSVPAFANGGYAEWYWWTLKNPSSDGGATQRYHEKEFGANFTYQDFVSRFDCRLFDANEWASIIEKSGAKYVVLTSKHHEGYTLWNSEQSWNWNSVETGPGIDIVGELTKSVKNMGLHMGLYHSLFEWFNPLYLADAETGKNPTTQVYVDEILMKQLKDIVTTYEPELIWADGDWMQLSNYWKSTEFLSWLYTNSSVKDTVIVNDRWGSECRDKNGGFYTGADHFNPYKLQSHKWENCATIGYSYGYDEYEQATDYQNATELIIDLVTTVACGGNFLLDVGPDAQGTIPNNMVDRLLEIGNWLSINSESIYGSSPWRVQNMTFNIWYTTNTTNGNVYAFVFELPDDGVLILSDPIGNNKTEATLLGLKGEKGVEVSLPIESTKPGITLNIPMVAPQDYPPYVYVFRLTDVE", "length": 461, "header": "sp|P10901-1|FUCO_DICDI Isoform 1 of Alpha-L-fucosidase OS=Dictyostelium discoideum OX=44689 GN=alfA PE=3 SV=1 CANONICAL=P10901-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycohydrolase-activity" ], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gl\u00f6ckner Gernot, Eichinger Ludwig, Szafranski Karol, Pachebat Justin A, Bankier Alan T, Dear Paul H, Lehmann R\u00fcdiger, Baumgart Cornelia, Parra Gen\u00eds, Abril Josep F, Guig\u00f3 Roderic, Kumpf Kai, Tunggal Budi, Cox Edward, Quail Michael A, Platzer Matthias, Rosenthal Andr\u00e9, Noegel Angelika A,", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "A developmentally regulated gene product from Dictyostelium discoideum shows high homology to human alpha-L-fucosidase.", "journal": "FEBS Lett.", "date": "1989", "authors": "M\u00fcller-Taubenberger A, Westphal M, Noegel A, Gerisch G", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "reference": [ { "type": "PubMed", "id": "2540036", "url": "https://glygen.org/publication/PubMed/2540036" } ] } ], "pathway": [ { "id": "ddi:DDB_G0274391", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0274391", "resource": "KEGG Pathway" }, { "id": "R-DDI-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-DDI-975578", "name": "Reactions specific to the complex N-glycan synthesis pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-975578", "resource": "Reactome", "description": "Reactions specific to the complex N-glycan synthesis pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to cAMP", "id": "GO:0051591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051591", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" }, { "name": "glycoside catabolic process", "id": "GO:0016139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016139", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" }, { "name": "fucose metabolic process", "id": "GO:0006004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006004", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "alpha-L-fucosidase activity", "id": "GO:0004560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004560", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" }, { "name": "1,6-alpha-L-fucosidase activity", "id": "GO:0033938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033938", "evidence": [ { "database": "UniProtKB", "id": "P10901", "url": "https://www.uniprot.org/uniprot/P10901" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12288", "name": "", "equation": "an alpha-L-fucoside + H2O = an alcohol + L-fucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYS4-1", "P17164-1", "Q9BTY2-1", "P04066-1", "Q99KR8-1", "Q99LJ1-1", "P10901-1", "Q9VTJ4-1" ], "evidence": [ { "id": "12288", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12288" } ] }, { "id": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-6784247" ], "output_participant_list": [ "R-ALL-6784248", "R-ALL-6784249" ], "enzyme_list": [ "Q551C1-1", "P10901-1" ], "evidence": [ { "id": "R-DDI-5693807", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5693807" } ] }, { "id": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54EG4-1", "Q54LD6-1", "Q551C1-1", "Q55B10-1", "Q54GE1-1", "Q54HL4-1", "Q54IF2-1", "Q54K56-1", "Q54NC1-1", "Q54SE2-1", "Q54YA0-1", "Q553U5-1", "Q55G10-1", "Q55FU1-1", "P10901-1", "P34098-1", "P34114-1", "P42525-1", "P54644-1", "Q00766-1", "Q54ME1-1", "Q54QQ0-1", "Q6TMK4-1", "Q7M438-1" ], "evidence": [ { "id": "R-DDI-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798751" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6784247", "participant_name": "NGP:1,6-GlcNAc [lysosomal lumen]", "crossref": [ { "id": "33837", "database": "ChEBI", "url": "" }, { "id": "33837", "database": "ChEBI", "url": "" }, { "id": "33837", "database": "ChEBI", "url": "" }, { "id": "33837", "database": "ChEBI", "url": "" }, { "id": "33837", "database": "ChEBI", "url": "" }, { "id": "33837", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-6784248", "participant_name": "NGP [lysosomal lumen]", "crossref": [ { "id": "59520", "database": "ChEBI", "url": "" }, { "id": "59520", "database": "ChEBI", "url": "" }, { "id": "59520", "database": "ChEBI", "url": "" }, { "id": "59520", "database": "ChEBI", "url": "" }, { "id": "59520", "database": "ChEBI", "url": "" }, { "id": "59520", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-6784249", "participant_name": "L-fucose [lysosomal lumen]", "crossref": [ { "id": "2181", "database": "ChEBI", "url": "" }, { "id": "G82576YO", "database": "GlyTouCan", "url": "" }, { "id": "C01019", "database": "COMPOUND", "url": "" }, { "id": "000001532814", "database": "ZINC", "url": "" }, { "id": "000001532813", "database": "ZINC", "url": "" }, { "id": "C01019", "database": "COMPOUND", "url": "" }, { "id": "000001532813", "database": "ZINC", "url": "" }, { "id": "2181", "database": "ChEBI", "url": "" }, { "id": "G82576YO", "database": "GlyTouCan", "url": "" }, { "id": "000001532814", "database": "ZINC", "url": "" }, { "id": "2181", "database": "ChEBI", "url": "" }, { "id": "G82576YO", "database": "GlyTouCan", "url": "" }, { "id": "C01019", "database": "COMPOUND", "url": "" }, { "id": "000001532814", "database": "ZINC", "url": "" }, { "id": "000001532813", "database": "ZINC", "url": "" }, { "id": "000001532813", "database": "ZINC", "url": "" }, { "id": "C01019", "database": "COMPOUND", "url": "" }, { "id": "2181", "database": "ChEBI", "url": "" }, { "id": "G82576YO", "database": "GlyTouCan", "url": "" }, { "id": "000001532814", "database": "ZINC", "url": "" }, { "id": "2181", "database": "ChEBI", "url": "" }, { "id": "G82576YO", "database": "GlyTouCan", "url": "" }, { "id": "C01019", "database": "COMPOUND", "url": "" }, { "id": "000001532814", "database": "ZINC", "url": "" }, { "id": "000001532813", "database": "ZINC", "url": "" }, { "id": "2181", "database": "ChEBI", "url": "" }, { "id": "G82576YO", "database": "GlyTouCan", "url": "" }, { "id": "C01019", "database": "COMPOUND", "url": "" }, { "id": "000001532814", "database": "ZINC", "url": "" }, { "id": "000001532813", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P04066", "gene_name": "FUCA1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "P04066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04066" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "P04066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04066" } ] } ] }, { "uniprot_ac": "P10901", "gene_name": "alfA", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "P10901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10901" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "P10901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10901" } ] } ] }, { "uniprot_ac": "P17164", "gene_name": "Fuca1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "P17164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17164" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "P17164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17164" } ] } ] }, { "uniprot_ac": "P34098", "gene_name": "manA", "activity": [ { "ec_number": "3.2.1.24", "activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", "evidence": [ { "id": "P34098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34098" } ] }, { "ec_number": "3.2.1.24", "activity": "", "evidence": [ { "id": "P34098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34098" } ] } ] }, { "uniprot_ac": "P34114", "gene_name": "glpD", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P34114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34114" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P34114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34114" } ] } ] }, { "uniprot_ac": "P42525", "gene_name": "erkA", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42525" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P42525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42525" } ] } ] }, { "uniprot_ac": "P54644", "gene_name": "pkbA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54644" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54644" } ] } ] }, { "uniprot_ac": "Q00766", "gene_name": "glpV", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q00766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00766" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q00766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00766" } ] } ] }, { "uniprot_ac": "Q54EG4", "gene_name": "", "activity": [ { "ec_number": "3.2.1.22", "activity": "a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose.", "evidence": [ { "id": "Q54EG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EG4" } ] }, { "ec_number": "3.2.1.22", "activity": "", "evidence": [ { "id": "Q54EG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EG4" } ] } ] }, { "uniprot_ac": "Q54GE1", "gene_name": "glb1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "Q54GE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GE1" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "Q54GE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GE1" } ] } ] }, { "uniprot_ac": "Q54HL4", "gene_name": "gghB", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "Q54HL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HL4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "Q54HL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HL4" } ] } ] }, { "uniprot_ac": "Q54IF2", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54IF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IF2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54IF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IF2" } ] } ] }, { "uniprot_ac": "Q54K56", "gene_name": "hexb2", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "Q54K56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K56" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "Q54K56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K56" } ] } ] }, { "uniprot_ac": "Q54LD6", "gene_name": "", "activity": [ { "ec_number": "3.5.2.17", "activity": "5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+).", "evidence": [ { "id": "Q54LD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LD6" } ] }, { "ec_number": "3.5.2.17", "activity": "", "evidence": [ { "id": "Q54LD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LD6" } ] } ] }, { "uniprot_ac": "Q54ME1", "gene_name": "gmsA", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q54ME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54ME1" } ] } ] }, { "uniprot_ac": "Q54NC1", "gene_name": "cyb5r1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q54NC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NC1" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q54NC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NC1" } ] } ] }, { "uniprot_ac": "Q54QQ0", "gene_name": "impdh", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "Q54QQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QQ0" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q54QQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QQ0" } ] } ] }, { "uniprot_ac": "Q54SE2", "gene_name": "", "activity": [ { "ec_number": "1.11.1.24", "activity": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O.", "evidence": [ { "id": "Q54SE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54SE2" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "Q54SE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54SE2" } ] } ] }, { "uniprot_ac": "Q54YA0", "gene_name": "acly", "activity": [ { "ec_number": "2.3.3.8", "activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.", "evidence": [ { "id": "Q54YA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54YA0" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q54YA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54YA0" } ] } ] }, { "uniprot_ac": "Q551C1", "gene_name": "", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q551C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q551C1" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q551C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q551C1" } ] } ] }, { "uniprot_ac": "Q553U5", "gene_name": "ADA2", "activity": [ { "ec_number": "3.5.4.4", "activity": "2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+).", "evidence": [ { "id": "Q553U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553U5" } ] }, { "ec_number": "3.5.4.4", "activity": "", "evidence": [ { "id": "Q553U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553U5" } ] } ] }, { "uniprot_ac": "Q55B10", "gene_name": "melA", "activity": [ { "ec_number": "3.2.1.22", "activity": "a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose.", "evidence": [ { "id": "Q55B10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55B10" } ] }, { "ec_number": "3.2.1.22", "activity": "", "evidence": [ { "id": "Q55B10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55B10" } ] } ] }, { "uniprot_ac": "Q55FU1", "gene_name": "", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "Q55FU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FU1" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "Q55FU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FU1" } ] } ] }, { "uniprot_ac": "Q55G10", "gene_name": "naprt", "activity": [ { "ec_number": "6.3.4.21", "activity": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate.", "evidence": [ { "id": "Q55G10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55G10" } ] }, { "ec_number": "6.3.4.21", "activity": "", "evidence": [ { "id": "Q55G10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55G10" } ] } ] }, { "uniprot_ac": "Q6AYS4", "gene_name": "Fuca2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q6AYS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS4" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q6AYS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS4" } ] } ] }, { "uniprot_ac": "Q6TMK4", "gene_name": "poxA", "activity": [ { "ec_number": "1.11.1.7", "activity": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O.", "evidence": [ { "id": "Q6TMK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6TMK4" } ] }, { "ec_number": "1.11.1.7", "activity": "", "evidence": [ { "id": "Q6TMK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6TMK4" } ] } ] }, { "uniprot_ac": "Q7M438", "gene_name": "ddiA", "activity": [ { "ec_number": "4.6.1.19", "activity": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+).", "evidence": [ { "id": "Q7M438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7M438" } ] }, { "ec_number": "4.6.1.19", "activity": "", "evidence": [ { "id": "Q7M438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7M438" } ] } ] }, { "uniprot_ac": "Q99KR8", "gene_name": "Fuca2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q99KR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR8" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q99KR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR8" } ] } ] }, { "uniprot_ac": "Q99LJ1", "gene_name": "Fuca1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q99LJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LJ1" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q99LJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LJ1" } ] } ] }, { "uniprot_ac": "Q9BTY2", "gene_name": "FUCA2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q9BTY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTY2" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q9BTY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BTY2" } ] } ] }, { "uniprot_ac": "Q9VTJ4", "gene_name": "Fuca", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q9VTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VTJ4" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q9VTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VTJ4" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 244, "end_pos": 246 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 90, "end_pos": 92 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }