{ "uniprot_canonical_ac": "P10819-1", "uniprot_ac": "P10819", "uniprot_id": "SAHH_DICDI", "mass": { "chemical_mass": 47280.0, "monoisotopic_mass": 47280.0 }, "refseq": { "ac": "XP_647635", "name": "AdoHyc hydrolase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_647635" }, "gene_names": [ { "name": "sahA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10819", "id": "P10819" }, { "name": "DDB_G0267418", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10819", "id": "P10819" }, { "name": "sahA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_647635", "id": "XP_647635" } ], "protein_names": [ { "name": "Adenosylhomocysteinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10819" }, { "name": "3.13.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10819" }, { "name": "AdoHcyase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10819" }, { "name": "AdoHyc hydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_647635", "id": "XP_647635" }, { "name": "S-adenosyl-L-homocysteine hydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_647635", "id": "XP_647635" }, { "name": "S-adenosyl-L-homocysteine hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10819" } ], "function": [ { "annotation": "Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "sahA", "url": "https://www.uniprot.org/uniprot/P10819", "locus": {} } ], "crossref": [ { "id": "cd00401", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00401", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0267418", "url": "http://dictybase.org/gene/DDB_G0267418", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8616450", "url": "https://www.ncbi.nlm.nih.gov/gene/8616450", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0267418", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0267418", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIGVTVE", "url": "https://omabrowser.org/oma/group/YIGVTVE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23420", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23420", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23420:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23420:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00670", "url": "http://pfam.xfam.org/family/PF00670", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05221", "url": "http://pfam.xfam.org/family/PF05221", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10819", "url": "http://purl.obolibrary.org/obo/PR_P10819", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-156581", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-156581", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-1614635", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1614635", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_647635", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_647635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21708", "url": "https://www.rhea-db.org/rhea/21708", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10819-1", "url": "https://www.uniprot.org/uniprot/P10819-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTKLHYKVKDISLAAWGRKEIEIAENEMPGLMTLRKKYGPAQILKGARIAGCLHMTIQTAVLIETLTALGAQVQWSSCNIFSTQDQAAAAIAATGVPVYAWKGETEEEYNWCVEQTIVFQDGQPLNMILDDGGDLTNLVHEKYPQFLAGIKGISEETTTGVHNLYKMFKEGKLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANAKKDTVKPQVDRYTLANGVHIILLAEGRLVNLGCGTGHPSFVMSNSFCNQTLAQIALWTKTEEYPLGVHFLPKILDEEVARLHLDQLGAKLTTLTEKQSEYLSVPVAGPYKVDHYRY", "length": 431, "header": "sp|P10819-1|SAHH_DICDI Isoform 1 of Adenosylhomocysteinase OS=Dictyostelium discoideum OX=44689 GN=sahA PE=1 SV=2 CANONICAL=P10819-1" }, "isoforms": [ { "isoform_ac": "P10819-1", "url": "", "sequence": { "sequence": "MTKLHYKVKDISLAAWGRKEIEIAENEMPGLMTLRKKYGPAQILKGARIAGCLHMTIQTAVLIETLTALGAQVQWSSCNIFSTQDQAAAAIAATGVPVYAWKGETEEEYNWCVEQTIVFQDGQPLNMILDDGGDLTNLVHEKYPQFLAGIKGISEETTTGVHNLYKMFKEGKLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANAKKDTVKPQVDRYTLANGVHIILLAEGRLVNLGCGTGHPSFVMSNSFCNQTLAQIALWTKTEEYPLGVHFLPKILDEEVARLHLDQLGAKLTTLTEKQSEYLSVPVAGPYKVDHYRY", "length": 431, "header": "sp|P10819-1|SAHH_DICDI Isoform 1 of Adenosylhomocysteinase OS=Dictyostelium discoideum OX=44689 GN=sahA PE=1 SV=2 CANONICAL=P10819-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Identification and isolation of Dictyostelium microtubule-associated protein interactors by tandem affinity purification.", "journal": "Eur. J. Cell Biol.", "date": "2006", "authors": "Koch Katrin V, Reinders Yvonne, Ho Thi-Hieu, Sickmann Albert, Gr\u00e4f Ralph", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "reference": [ { "type": "PubMed", "id": "16782229", "url": "https://glygen.org/publication/PubMed/16782229" } ] }, { "title": "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake.", "journal": "Mol. Cell. Proteomics", "date": "2006", "authors": "Gotthardt Daniel, Blancheteau Vincent, Bosserhoff Armin, Ruppert Thomas, Delorenzi Mauro, Soldati Thierry", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "reference": [ { "type": "PubMed", "id": "16926386", "url": "https://glygen.org/publication/PubMed/16926386" } ] }, { "title": "Cloning of a cDNA for the S-adenosyl-L-homocysteine hydrolase from Dictyostelium discoideum.", "journal": "Biochimie", "date": "1988", "authors": "Guitton M C, Part D, Veron M", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "reference": [ { "type": "PubMed", "id": "3139100", "url": "https://glygen.org/publication/PubMed/3139100" } ] }, { "title": "Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from Dictyostelium discoideum as deduced from the cDNA sequence.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1988", "authors": "Kasir J, Aksamit R R, Backlund P S, Cantoni G L", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "reference": [ { "type": "PubMed", "id": "3288206", "url": "https://glygen.org/publication/PubMed/3288206" } ] } ], "pathway": [ { "id": "ddi:DDB_G0267418", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0267418", "resource": "KEGG Pathway" }, { "id": "R-DDI-156581", "name": "Methylation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-156581", "resource": "Reactome", "description": "Methylation" }, { "id": "R-DDI-1614635", "name": "Sulfur amino acid metabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1614635", "resource": "Reactome", "description": "Sulfur amino acid metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "actin rod", "id": "GO:0031002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031002", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "one-carbon metabolic process", "id": "GO:0006730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "establishment or maintenance of cell polarity", "id": "GO:0007163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007163", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "S-adenosylmethionine cycle", "id": "GO:0033353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033353", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "adenosylhomocysteinase activity", "id": "GO:0004013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004013", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" }, { "name": "cAMP binding", "id": "GO:0030552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030552", "evidence": [ { "database": "UniProtKB", "id": "P10819", "url": "https://www.uniprot.org/uniprot/P10819" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21708", "name": "", "equation": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10760-1", "P23526-1", "Q96HN2-1", "P50247-1", "Q68FL4-1", "P39954-1", "P10819-1", "Q27580-1" ], "evidence": [ { "id": "21708", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21708" } ] }, { "id": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-83909" ], "enzyme_list": [ "P10819-1" ], "evidence": [ { "id": "R-DDI-174401", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-174401" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-83909", "participant_name": "Ade-Rib [cytosol]", "crossref": [ { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" }, { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" }, { "id": "C00212", "database": "COMPOUND", "url": "" }, { "id": "16335", "database": "ChEBI", "url": "" }, { "id": "8143428", "database": "PubChem Substance", "url": "" }, { "id": "000002169830", "database": "ZINC", "url": "" }, { "id": "2844", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000050", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P10760", "gene_name": "Ahcy", "activity": [ { "ec_number": "3.13.2.1", "activity": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine.", "evidence": [ { "id": "P10760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10760" } ] }, { "ec_number": "3.13.2.1", "activity": "", "evidence": [ { "id": "P10760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10760" } ] } ] }, { "uniprot_ac": "P10819", "gene_name": "sahA", "activity": [ { "ec_number": "3.13.2.1", "activity": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine.", "evidence": [ { "id": "P10819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10819" } ] }, { "ec_number": "3.13.2.1", "activity": "", "evidence": [ { "id": "P10819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10819" } ] } ] }, { "uniprot_ac": "P23526", 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