{ "uniprot_canonical_ac": "P10768-1", "uniprot_ac": "P10768", "uniprot_id": "ESTD_HUMAN", "mass": { "chemical_mass": 31463.0, "monoisotopic_mass": 31463.0 }, "refseq": { "ac": "NP_001975", "name": "S-formylglutathione hydrolase", "summary": "This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975" }, "gene_names": [ { "name": "ESD", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10768", "id": "P10768" }, { "name": "ESD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975", "id": "NP_001975" }, { "name": "FGH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975", "id": "NP_001975" }, { "name": "hCG_29992", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10768", "id": "P10768" } ], "protein_names": [ { "name": "S-formylglutathione hydrolase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10768" }, { "name": "3.1.1.56", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10768" }, { "name": "3.1.2.12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10768" }, { "name": "Esterase D", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10768" }, { "name": "FGH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10768" }, { "name": "Methylumbelliferyl-acetate deacetylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10768" }, { "name": "S-formylglutathione hydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975", "id": "NP_001975" }, { "name": "esterase D/formylglutathione hydrolase; esterase 10; methylumbelliferyl-acetate deacetylase; testicular tissue protein Li 66", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975", "id": "NP_001975" } ], "function": [ { "annotation": "Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro.", "evidence": [ { "database": "RefSeq", "id": "NP_001975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975" }, { "database": "PubMed", "id": "36649442", "url": "https://glygen.org/publication/PubMed/36649442" } ] }, { "annotation": "Serine hydrolase involved in the detoxification of formaldehyde.", "evidence": [ { "database": "UniProtKB", "id": "H7BZT7", "url": "https://www.uniprot.org/uniprot/H7BZT7#function" }, { "database": "UniProtKB", "id": "RU363068", "url": "https://www.uniprot.org/uniprot/RU363068#function" }, { "database": "UniProtKB", "id": "ARBA00002608", "url": "https://www.uniprot.org/uniprot/ARBA00002608#function" }, { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768#function" }, { "database": "PubMed", "id": "4768551", "url": "https://glygen.org/publication/PubMed/4768551" }, { "database": "PubMed", "id": "3770744", "url": "https://glygen.org/publication/PubMed/3770744" }, { "database": "UniProtKB", "id": "X6RA14", "url": "https://www.uniprot.org/uniprot/X6RA14#function" }, { "database": "UniProtKB", "id": "U3KQT1", "url": "https://www.uniprot.org/uniprot/U3KQT1#function" } ] }, { "annotation": "This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_001975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 149, "end_pos": 149, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 149, "end_pos": 149, "sequence_org": "S", "sequence_mut": "T", "comment": "1.3% of wild-type activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 150, "end_pos": 150, "sequence_org": "M", "sequence_mut": "A", "comment": "62% increase in activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 226, "end_pos": 226, "sequence_org": "D", "sequence_mut": "A", "comment": "4.3% of wild-type activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 226, "end_pos": 226, "sequence_org": "D", "sequence_mut": "N", "comment": "9% of wild-type activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 260, "end_pos": 260, "sequence_org": "H", "sequence_mut": "A", "comment": "3% of wild-type activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 260, "end_pos": 260, "sequence_org": "H", "sequence_mut": "Q", "comment": "1.3% of wild-type activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "start_pos": 54, "end_pos": 54, "sequence_org": "L", "sequence_mut": "A", "comment": "83% of wild-type activity.", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "96.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "97.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "96.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "97.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "98.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "98.64", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "96.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "98.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "98.1", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "93.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "97.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "96.9", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "97.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139684", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139684" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P10768", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10768" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P10768", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10768" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10768" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA", "length": 282, "header": "sp|P10768-1|ESTD_HUMAN Isoform 1 of S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2 CANONICAL=P10768-1" }, "locus": { "chromosome": "13", "start_pos": 46791413, "end_pos": 46771419, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378720.8", "url": "https://www.ensembl.org/id/ENST00000378720.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000367992.3", "url": "https://www.ensembl.org/id/ENSP00000367992.3" } ] } }, { "isoform_ac": "U3KQT1-1", "url": "", "sequence": { "sequence": "MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEASIRKL", "length": 262, "header": "tr|U3KQT1-1|ESTD_HUMAN Computationally mapped isoform of S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2 CANONICAL=P10768-1" }, "locus": { "chromosome": "13", "start_pos": 46791413, "end_pos": 46777438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000471867.3", "url": "https://www.ensembl.org/id/ENST00000471867.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000476193.2", "url": "https://www.ensembl.org/id/ENSP00000476193.2" } ] } }, { "isoform_ac": "X6RA14-1", "url": "", "sequence": { "sequence": "MKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA", "length": 253, "header": "tr|X6RA14-1|X6RA14_HUMAN Computationally mapped isoform of S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=1 CANONICAL=P10768-1" }, "locus": { "chromosome": "13", "start_pos": 46787090, "end_pos": 46771419, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378697.5", "url": "https://www.ensembl.org/id/ENST00000378697.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000367969.1", "url": "https://www.ensembl.org/id/ENSP00000367969.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P10768", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10768" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.", "journal": "Journal of molecular biology", "date": "1999", "authors": "Bruns CM, Hubatsch I, Ridderstrom M, Mannervik B, Tainer JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "10329152", "url": "https://glygen.org/publication/PubMed/10329152" } ] }, { "title": "An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.", "journal": "Biochemistry", "date": "1999", "authors": "Patskovsky YV, Patskovska LN, Listowsky I", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "10587441", "url": "https://glygen.org/publication/PubMed/10587441" } ] }, { "title": "Identification, characterization, and crystal structure of the Omega class glutathione transferases.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "10783391", "url": "https://glygen.org/publication/PubMed/10783391" } ] }, { "title": "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Hu R M, Han Z G, Song H D, Peng Y D, Huang Q H, Ren S X, Gu Y J, Huang C H, Li Y B, Jiang C L, Fu G, Zhang Q H, Gu B W, Dai M, Mao Y F, Gao G F, Rong R, Ye M, Zhou J, Xu S H, Gu J, Shi J X, Jin W R, Zhang C K, Wu T M, Huang G Y, Chen Z, Chen M D, Chen J L", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "10931946", "url": "https://glygen.org/publication/PubMed/10931946" } ] }, { "title": "Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.", "journal": "Biochemistry", "date": "2001", "authors": "Polekhina G, Board PG, Blackburn AC, Parker MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "11327815", "url": "https://glygen.org/publication/PubMed/11327815" } ] }, { "title": "The 3-D structure of microsomal glutathione transferase 1 at 6 A resolution as determined by electron crystallography of p22(1)2(1) crystals.", "journal": "Biochimica et biophysica acta", "date": "2002", "authors": "Holm PJ, Morgenstern R, Hebert H", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "11904223", "url": "https://glygen.org/publication/PubMed/11904223" } ] }, { "title": "The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.", "journal": "Pharmacogenetics", "date": "2002", "authors": "Morel F, Rauch C, Coles B, Le Ferrec E, Guillouzo A", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "12042665", "url": "https://glygen.org/publication/PubMed/12042665" } ] }, { "title": "1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site.", "journal": "Proteins", "date": "2002", "authors": "Le Trong I, Stenkamp RE, Ibarra C, Atkins WM, Adman ET", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "12211029", "url": "https://glygen.org/publication/PubMed/12211029" } ] }, { "title": "Mechanism of metal activation of human hematopoietic prostaglandin D synthase.", "journal": "Nature structural biology", "date": "2003", "authors": "Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "12627223", "url": "https://glygen.org/publication/PubMed/12627223" } ] }, { "title": "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.", "journal": "Journal of human genetics", "date": "2003", "authors": "Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, Nakamura Y", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "12721789", "url": "https://glygen.org/publication/PubMed/12721789" } ] }, { "title": "Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Morel F, Rauch C, Petit E, Piton A, Theret N, Coles B, Guillouzo A", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "14742434", "url": "https://glygen.org/publication/PubMed/14742434" } ] }, { "title": "Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme.", "journal": "Protein science : a publication of the Protein Society", "date": "2005", "authors": "Li J, Xia Z, Ding J", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "16081649", "url": "https://glygen.org/publication/PubMed/16081649" } ] }, { "title": "Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant.", "journal": "Journal of molecular biology", "date": "2006", "authors": "Tars K, Larsson AK, Shokeer A, Olin B, Mannervik B, Kleywegt GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "16298388", "url": "https://glygen.org/publication/PubMed/16298388" } ] }, { "title": "Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a.", "journal": "Biochemistry", "date": "2006", "authors": "Patskovsky Y, Patskovska L, Almo SC, Listowsky I", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "16548513", "url": "https://glygen.org/publication/PubMed/16548513" } ] }, { "title": "Crystal structure of human esterase D: a potential genetic marker of retinoblastoma.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2009", "authors": "Wu D, Li Y, Song G, Zhang D, Shaw N, Liu ZJ", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "19126594", "url": "https://glygen.org/publication/PubMed/19126594" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.", "journal": "Journal of molecular biology", "date": "2010", "authors": "Tars K, Olin B, Mannervik B", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "20083122", "url": "https://glygen.org/publication/PubMed/20083122" } ] }, { "title": "Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.", "journal": "Biochemistry", "date": "2010", "authors": "Balogh LM, Le Trong I, Kripps KA, Shireman LM, Stenkamp RE, Zhang W, Mannervik B, Atkins WM", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "20085333", "url": "https://glygen.org/publication/PubMed/20085333" } ] }, { "title": "Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Zhou H, Brock J, Casarotto MG, Oakley AJ, Board PG", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "21106529", "url": "https://glygen.org/publication/PubMed/21106529" } ] }, { "title": "Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.", "journal": "Journal of neurochemistry", "date": "2011", "authors": "Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "21668448", "url": "https://glygen.org/publication/PubMed/21668448" } ] }, { "title": "Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.", "journal": "Journal of molecular biology", "date": "2012", "authors": "Zhou H, Brock J, Liu D, Board PG, Oakley AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "22522127", "url": "https://glygen.org/publication/PubMed/22522127" } ] }, { "title": "The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones.", "journal": "Frontiers in pharmacology", "date": "2012", "authors": "Zhang L, Jin Y, Huang M, Penning TM", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "23162467", "url": "https://glygen.org/publication/PubMed/23162467" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10768", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10768" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastoma.", "journal": "Hum. Genet.", "date": "1988", "authors": "Young LJ, Lee EY, To HA, Bookstein R, Shew JY, Donoso LA, Sery T, Giblin M, Shields JA, Lee WH", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "3164702", "url": "https://glygen.org/publication/PubMed/3164702" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10768", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10768" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "Gene expression of rat and human microsomal glutathione S-transferases.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "DeJong JL, Morgenstern R, Jornvall H, DePierre JW, Tu CP", "evidence": [ { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "3372534", "url": "https://glygen.org/publication/PubMed/3372534" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10768", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10768" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10768", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10768" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1986", "authors": "Lee E Y, Lee W H", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "3462698", "url": "https://glygen.org/publication/PubMed/3462698" } ] }, { "title": "Cloning of the esterase D gene: a polymorphic gene probe closely linked to the retinoblastoma locus on chromosome 13.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1986", "authors": "Squire J, Dryja T P, Dunn J, Goddard A, Hofmann T, Musarella M, Willard H F, Becker A J, Gallie B L, Phillips R A", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "3462714", "url": "https://glygen.org/publication/PubMed/3462714" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10768", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10768" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro.", "journal": "Journal of cellular biochemistry", "date": "2023-03", "authors": "Yao Wen, Chen Xinpeng, Cui Xiaoling, Zhou Bangzhao, Zhao Baoxiang, Lin ZhaoMin, Miao Junying", "evidence": [ { "database": "RefSeq", "id": "NP_001975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001975" } ], "reference": [ { "type": "PubMed", "id": "36649442", "url": "https://glygen.org/publication/PubMed/36649442" } ] }, { "title": "Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells.", "journal": "Human genetics", "date": "1986", "authors": "Eiberg H, Mohr J", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "3770744", "url": "https://glygen.org/publication/PubMed/3770744" } ] }, { "title": "Esterase D: a new human polymorphism.", "journal": "Annals of human genetics", "date": "1973", "authors": "Hopkinson DA, Mestriner MA, Cortner J, Harris H", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" }, { "database": "Reactome", "id": "R-HSA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156590" } ], "reference": [ { "type": "PubMed", "id": "4768551", "url": "https://glygen.org/publication/PubMed/4768551" } ] }, { "title": "Molecular analysis of esterase D polymorphism.", "journal": "Human genetics", "date": "1994", "authors": "Tsuchida S, Fukui E, Ikemoto S", "evidence": [ { "database": "UniProtKB", "id": "P10768", "url": "https://www.uniprot.org/uniprot/P10768" } ], "reference": [ { "type": "PubMed", "id": "7907313", "url": "https://glygen.org/publication/PubMed/7907313" } ] }, { "title": "Crystal structure of human class mu glutathione transferase GSTM2-2. 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