{ "uniprot_canonical_ac": "P10733-1", "uniprot_ac": "P10733", "uniprot_id": "SEVE_DICDI", "mass": { "chemical_mass": 39870.0, "monoisotopic_mass": 39870.0 }, "refseq": { "ac": "XP_001134515", "name": "hypothetical protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001134515" }, "gene_names": [ { "name": "sevA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10733", "id": "P10733" }, { "name": "DDB_G0289327", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10733", "id": "P10733" }, { "name": "sevA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001134515", "id": "XP_001134515" } ], "protein_names": [ { "name": "Severin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10733" }, { "name": "hypothetical protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001134515", "id": "XP_001134515" } ], "function": [ { "annotation": "Severin blocks the ends of F-actin and causes the fragmentation and depolymerization of actin filaments in a Ca(2+) dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "sevA", "url": "https://www.uniprot.org/uniprot/P10733", "locus": {} } ], "crossref": [ { "id": "cd11289", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11289", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11290", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11290", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11292", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11292", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0289327", "url": "http://dictybase.org/gene/DDB_G0289327", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8627096", "url": "https://www.ncbi.nlm.nih.gov/gene/8627096", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0289327", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0289327", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ALWLKVA", "url": "https://omabrowser.org/oma/group/ALWLKVA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11977:SF130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11977:SF130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1SVQ", "url": "https://www.rcsb.org/structure/1SVQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1SVR", "url": "https://www.rcsb.org/structure/1SVR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1SVY", "url": "https://www.rcsb.org/structure/1SVY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00626", "url": "http://pfam.xfam.org/family/PF00626", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10733", "url": "http://purl.obolibrary.org/obo/PR_P10733", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_001134515", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001134515", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10733-1", "url": "https://www.uniprot.org/uniprot/P10733-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKNRKLDITSTNVAGIGTDLDKKCRLDAASTEAQWKGVGQAPGLKIWRIENFKVVPVPESSYGKFYDGDSYIILHTFKEGNSLKHDIHFFLGTFTTQDEAGTAAYKTVELDDFLGGAPIQYRQCQSYESPSFLSLFPKYFILSGGVESGFNHVKPTEYKPRLLHISGDKNAKVAEVPLATSSLNSGDCFLLDAGLTIYQFNGSKSSPQEKNKAAEVARAIDAERKGLPKVEVFCETDSDIPAEFWKLLGGKGAIAAKHETAPTKSEKVLYKLSDASGSLKFSEVSRGKINKSSLKSEDVFIIDLGNEIYTWIGSKSSPNEKKTAFSHATQYLVNNKRCEYTPIVRVLENGTNQSFETLLSA", "length": 362, "header": "sp|P10733-1|SEVE_DICDI Isoform 1 of Severin OS=Dictyostelium discoideum OX=44689 GN=sevA PE=1 SV=1 CANONICAL=P10733-1" }, "isoforms": [ { "isoform_ac": "P10733-1", "url": "", "sequence": { "sequence": "MIKNRKLDITSTNVAGIGTDLDKKCRLDAASTEAQWKGVGQAPGLKIWRIENFKVVPVPESSYGKFYDGDSYIILHTFKEGNSLKHDIHFFLGTFTTQDEAGTAAYKTVELDDFLGGAPIQYRQCQSYESPSFLSLFPKYFILSGGVESGFNHVKPTEYKPRLLHISGDKNAKVAEVPLATSSLNSGDCFLLDAGLTIYQFNGSKSSPQEKNKAAEVARAIDAERKGLPKVEVFCETDSDIPAEFWKLLGGKGAIAAKHETAPTKSEKVLYKLSDASGSLKFSEVSRGKINKSSLKSEDVFIIDLGNEIYTWIGSKSSPNEKKTAFSHATQYLVNNKRCEYTPIVRVLENGTNQSFETLLSA", "length": 362, "header": "sp|P10733-1|SEVE_DICDI Isoform 1 of Severin OS=Dictyostelium discoideum OX=44689 GN=sevA PE=1 SV=1 CANONICAL=P10733-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Mapping the functional surface of domain 2 in the gelsolin superfamily.", "journal": "Biochemistry", "date": "2000", "authors": "Puius Y A, Fedorov E V, Eichinger L, Schleicher M, Almo S C", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "reference": [ { "type": "PubMed", "id": "10820002", "url": "https://glygen.org/publication/PubMed/10820002" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake.", "journal": "Mol. Cell. Proteomics", "date": "2006", "authors": "Gotthardt Daniel, Blancheteau Vincent, Bosserhoff Armin, Ruppert Thomas, Delorenzi Mauro, Soldati Thierry", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "reference": [ { "type": "PubMed", "id": "16926386", "url": "https://glygen.org/publication/PubMed/16926386" } ] }, { "title": "Domain structure in actin-binding proteins: expression and functional characterization of truncated severin.", "journal": "J. Cell Biol.", "date": "1991", "authors": "Eichinger L, Noegel A A, Schleicher M", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "reference": [ { "type": "PubMed", "id": "1847147", "url": "https://glygen.org/publication/PubMed/1847147" } ] }, { "title": "Severin, gelsolin, and villin share a homologous sequence in regions presumed to contain F-actin severing domains.", "journal": "J. Biol. Chem.", "date": "1988", "authors": "Andr\u00e9 E, Lottspeich F, Schleicher M, Noegel A", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "reference": [ { "type": "PubMed", "id": "2826459", "url": "https://glygen.org/publication/PubMed/2826459" } ] }, { "title": "Structure of severin domain 2 in solution.", "journal": "J. Mol. Biol.", "date": "1995", "authors": "Schnuchel A, Wiltscheck R, Eichinger L, Schleicher M, Holak T A", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "reference": [ { "type": "PubMed", "id": "7897658", "url": "https://glygen.org/publication/PubMed/7897658" } ] } ], "pathway": [ { "id": "ddi:DDB_G0289327", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0289327", "resource": "KEGG Pathway" }, { "id": "R-DDI-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin filament severing activity", "id": "GO:0003789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003789", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "barbed-end actin filament capping", "id": "GO:0051016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051016", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin filament bundle assembly", "id": "GO:0051017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin polymerization or depolymerization", "id": "GO:0008154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008154", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin filament severing", "id": "GO:0051014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051014", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" }, { "name": "actin filament fragmentation", "id": "GO:0030043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030043", "evidence": [ { "database": "UniProtKB", "id": "P10733", "url": "https://www.uniprot.org/uniprot/P10733" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], 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