{ "uniprot_canonical_ac": "P10244-1", "uniprot_ac": "P10244", "uniprot_id": "MYBB_HUMAN", "mass": { "chemical_mass": 78764.0, "monoisotopic_mass": 78764.0 }, "refseq": { "ac": "NP_001265539", "name": "myb-related protein B isoform 2", "summary": "The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" }, "gene_names": [ { "name": "MYBL2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10244", "id": "P10244" }, { "name": "B-MYB; BMYB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539", "id": "NP_001265539" }, { "name": "BMYB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10244", "id": "P10244" }, { "name": "MYBL2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539", "id": "NP_001265539" } ], "protein_names": [ { "name": "Myb-related protein B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10244" }, { "name": "B-Myb", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10244" }, { "name": "MYB-related protein B; myb-like protein 2; v-myb myeloblastosis viral oncogene homolog-like 2; v-myb avian myeloblastosis viral oncogene homolog-like 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539", "id": "NP_001265539" }, { "name": "Myb-like protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10244" }, { "name": "myb-related protein B isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539", "id": "NP_001265539" } ], "function": [ { "annotation": "MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" }, { "database": "PubMed", "id": "36494680", "url": "https://glygen.org/publication/PubMed/36494680" } ] }, { "annotation": "Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" }, { "database": "PubMed", "id": "36854682", "url": "https://glygen.org/publication/PubMed/36854682" } ] }, { "annotation": "The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" } ] }, { "annotation": "Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" }, { "database": "PubMed", "id": "36812959", "url": "https://glygen.org/publication/PubMed/36812959" } ] }, { "annotation": "Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244#function" }, { "database": "PubMed", "id": "10770937", "url": "https://glygen.org/publication/PubMed/10770937" } ] }, { "annotation": "Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" }, { "database": "PubMed", "id": "37030434", "url": "https://glygen.org/publication/PubMed/37030434" } ] }, { "annotation": "[High expression of MYBL2 promotes progression and predicts a poor survival outcome of prostate cancer].", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" }, { "database": "PubMed", "id": "36073208", "url": "https://glygen.org/publication/PubMed/36073208" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs79958576", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs79958576" }, { "id": "rs79958576", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs79958576" }, { "id": "rs79958576", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs79958576" }, { "id": "rs79958576", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs79958576#frequency_tab" }, { "id": "rs79958576", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs79958576" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 191, "end_pos": 191, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SES->NES).", "chr_id": "20", "chr_pos": "43692228", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.01038", "site_lbl": "S191", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1316249498", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1316249498" }, { "id": "rs1316249498", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1316249498" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 229, "end_pos": 229, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NWP->NWS).", "chr_id": "20", "chr_pos": "43699778", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P229", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P10244", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10244" } ], "glycoeffect": [], "start_pos": 265, "end_pos": 265, "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "R", "sequence_mut": "*", "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%).", "chr_id": "20", "chr_pos": "43699886", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R265", "keywords": [ "biomuta", "somatic", "cancer" ] }, { "evidence": [ { "id": "rs796150259", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs796150259" }, { "id": "rs796150259", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs796150259#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 377, "end_pos": 377, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TIS->NIS).", "chr_id": "20", "chr_pos": "43702668", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T377", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1383760040", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1383760040" }, { "id": "rs1383760040", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1383760040#frequency_tab" }, { "id": "rs1383760040", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1383760040" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 427, "end_pos": 427, "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 1 filters: n-glyco-sequon-gain (STS->NTS).", "chr_id": "20", "chr_pos": "43702818", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S427", "keywords": [ "ebi", "somatic" ] }, { "evidence": [ { "id": "rs562055772", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs562055772" }, { "id": "rs562055772", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs562055772" }, { "id": "rs562055772", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs562055772" }, { "id": "rs562055772", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs562055772#frequency_tab" }, { "id": "rs562055772", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs562055772" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 438, "end_pos": 438, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SLT->NLT).", "chr_id": "20", "chr_pos": "43702851", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "S438", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs753850459", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753850459" }, { "id": "rs753850459", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753850459" }, { "id": "rs753850459", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs753850459#frequency_tab" }, { "id": "rs753850459", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs753850459" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 516, "end_pos": 516, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTP->NTT).", "chr_id": "20", "chr_pos": "43710003", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P516", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1254614860", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1254614860" }, { "id": "rs1254614860", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1254614860" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 607, "end_pos": 607, "sequence_org": "S", "sequence_mut": "C", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->C).", "chr_id": "20", "chr_pos": "43713102", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S607", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "66.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "75.6", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "71", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "82.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "53.49", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "79.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "81.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "54.17", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "53.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "73.14", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "56.06", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "56.5", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "59.86", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P10244", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10244" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer 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"url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P10244", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10244" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P10244", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10244" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P10244", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10244" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P10244", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10244" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "common_name": "Human" } ], "gene": [ { "name": "MYBL2", "url": "https://www.uniprot.org/uniprot/P10244", "locus": { "chromosome": "20", "start_pos": 43716495, "end_pos": 43667019, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000101057", "url": "https://www.ensembl.org/id/ENSG00000101057" } ] } } ], "crossref": [ { "id": "ENSG00000101057", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000101057", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P10244", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10244", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd00167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "MYBL2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYBL2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "4605", "url": "https://www.ncbi.nlm.nih.gov/gene/4605", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "7548", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7548", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P10244", "url": "https://www.ebi.ac.uk/intact/interactors/id:P10244*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4605", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4605", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "601415", "url": "http://www.omim.org/entry/601415", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P10244", "url": "https://www.nextprot.org/entry/NX_P10244", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P10244", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10244", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "EWETVVC", "url": "https://omabrowser.org/oma/group/EWETVVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "20023at2759", "url": "http://www.orthodb.org/?query=20023at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45614:SF69", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45614:SF69", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6C48", "url": "https://www.rcsb.org/structure/6C48", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00249", "url": "http://pfam.xfam.org/family/PF00249", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09316", "url": "http://pfam.xfam.org/family/PF09316", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13921", "url": "http://pfam.xfam.org/family/PF13921", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P10244", "url": "https://pharos.nih.gov/targets/P10244", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P10244", "url": "http://purl.obolibrary.org/obo/PR_P10244", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1362300", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1362300", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8869496", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8869496", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10244-1", "url": "https://www.uniprot.org/uniprot/P10244-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10244-2", "url": "https://www.uniprot.org/uniprot/P10244-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQPSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMSTLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS", "length": 700, "header": "sp|P10244-1|MYBB_HUMAN Isoform 1 of Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1 CANONICAL=P10244-1" }, "isoforms": [ { "isoform_ac": "P10244-1", "url": "", "sequence": { "sequence": "MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQPSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMSTLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS", "length": 700, "header": "sp|P10244-1|MYBB_HUMAN Isoform 1 of Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1 CANONICAL=P10244-1" }, "locus": { "chromosome": "20", "start_pos": 43716084, "end_pos": 43667284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000217026.5", "url": "https://www.ensembl.org/id/ENST00000217026.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000217026.4", "url": "https://www.ensembl.org/id/ENSP00000217026.4" } ] } }, { "isoform_ac": "P10244-2", "url": "", "sequence": { "sequence": "MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEENRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQPSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMSTLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS", "length": 676, "header": "sp|P10244-2|MYBB_HUMAN Isoform 2 of Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1 CANONICAL=P10244-1" }, "locus": { "chromosome": "20", "start_pos": 43716084, "end_pos": 43667284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000396863.8", "url": "https://www.ensembl.org/id/ENST00000396863.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000380072.4", "url": "https://www.ensembl.org/id/ENSP00000380072.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 607, "start_aa": "Ser", "end_pos": 607, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser607", "evidence": [ { "id": "P10244", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10244" }, { "id": "26960196", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26960196" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" } ] } ], "phosphorylation": [ { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Ser241" }, { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr266" }, { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" }, { "database": "phospho.ELM", "id": "P10244", "url": "http://phospho.elm.eu.org/byAccession/P10244.html" } ], "site_lbl": "Thr266" }, { "start_pos": 282, "end_pos": 282, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "28128338", "url": "https://glygen.org/publication/PubMed/28128338" } ], "site_lbl": "Ser282" }, { "start_pos": 286, "end_pos": 286, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "28128338", "url": "https://glygen.org/publication/PubMed/28128338" } ], "site_lbl": "Thr286" }, { "start_pos": 287, "end_pos": 287, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "28128338", "url": "https://glygen.org/publication/PubMed/28128338" } ], "site_lbl": "Ser287" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "30206359", "url": "https://glygen.org/publication/PubMed/30206359" } ], "site_lbl": "Ser28" }, { "start_pos": 393, "end_pos": 393, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" } ], "site_lbl": "Ser393" }, { "start_pos": 393, "end_pos": 393, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" }, { "database": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" }, { "database": "phospho.ELM", "id": "P10244", "url": "http://phospho.elm.eu.org/byAccession/P10244.html" } ], "site_lbl": "Ser393" }, { "start_pos": 405, "end_pos": 405, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" } ], "site_lbl": "Thr405" }, { "start_pos": 440, "end_pos": 440, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10095772", "url": "https://glygen.org/publication/PubMed/10095772" } ], "site_lbl": "Thr440" }, { "start_pos": 440, "end_pos": 440, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by CDK2", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "10095772", "url": "https://glygen.org/publication/PubMed/10095772" } ], "site_lbl": "Thr440" }, { "start_pos": 444, "end_pos": 444, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" }, { "database": "PubMed", "id": "9840932", "url": "https://glygen.org/publication/PubMed/9840932" }, { "database": "phospho.ELM", "id": "P10244", "url": "http://phospho.elm.eu.org/byAccession/P10244.html" } ], 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chemistry", "date": "1999", "authors": "Johnson TK, Schweppe RE, Septer J, Lewis RE", "evidence": [ { "database": "iPTMnet", "id": "P10244-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244-1" } ], "reference": [ { "type": "PubMed", "id": "10593981", "url": "https://glygen.org/publication/PubMed/10593981" } ] }, { "title": "Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Cervellera M, Raschella G, Santilli G, Tanno B, Ventura A, Mancini C, Sevignani C, Calabretta B, Sala A", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "10770937", "url": "https://glygen.org/publication/PubMed/10770937" } ] }, { "title": "Plk1 promotes nuclear translocation of human Cdc25C during prophase.", "journal": "EMBO reports", "date": "2002", "authors": "Toyoshima-Morimoto F, Taniguchi E, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "11897663", "url": "https://glygen.org/publication/PubMed/11897663" } ] }, { "title": "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex.", "journal": "Genes & development", "date": "2002", "authors": "Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-1362300", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1362300" } ], "reference": [ { "type": "PubMed", "id": "11959842", "url": "https://glygen.org/publication/PubMed/11959842" } ] }, { "title": "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "12738781", "url": "https://glygen.org/publication/PubMed/12738781" } ] }, { "title": "Coupling morphogenesis to mitotic entry.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Sakchaisri K, Asano S, Yu LR, Shulewitz MJ, Park CJ, Park JE, Cho YW, Veenstra TD, Thorner J, Lee KS", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "15037762", "url": "https://glygen.org/publication/PubMed/15037762" } ] }, { "title": "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "15070733", "url": "https://glygen.org/publication/PubMed/15070733" } ] }, { "title": "Large-scale characterization of HeLa cell nuclear phosphoproteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "P10244-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244-1" } ], "reference": [ { "type": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ] }, { "title": "FoxM1 is required for execution of the mitotic programme and chromosome stability.", "journal": "Nature cell biology", "date": "2005", "authors": "Laoukili J, Kooistra MR, Bras A, Kauw J, Kerkhoven RM, Morrison A, Clevers H, Medema RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "15654331", "url": "https://glygen.org/publication/PubMed/15654331" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation.", "journal": "EMBO reports", "date": "2007", "authors": "Liu H, Tan BC, Tseng KH, Chuang CP, Yeh CW, Chen KD, Lee SC, Yung BY", "evidence": [ { "database": "Reactome", "id": "R-HSA-8869496", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8869496" } ], "reference": [ { "type": "PubMed", "id": "17318229", "url": "https://glygen.org/publication/PubMed/17318229" } ] }, { "title": "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.", "journal": "Mol. Cell", "date": "2007", "authors": "Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson SK, Velmurugan S, Chen R, Washburn MP, Liu XS, DeCaprio JA", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "17531812", "url": "https://glygen.org/publication/PubMed/17531812" } ] }, { "title": "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.", "journal": "Cell Cycle", "date": "2007", "authors": "Schmit Fabienne, Korenjak Michael, Mannefeld Mirijam, Schmitt Kathrin, Franke Claudia, von Eyss Bj\u00f6rn, Gagrica Sladjana, H\u00e4nel Frank, Brehm Alexander, Gaubatz Stefan", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "17671431", "url": "https://glygen.org/publication/PubMed/17671431" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "P10244-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.", "journal": "Nature cell biology", "date": "2008", "authors": "Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "19160488", "url": "https://glygen.org/publication/PubMed/19160488" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "P10244-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.", "journal": "Genes & development", "date": "2012", "authors": "Sadasivam S, Duan S, DeCaprio JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "22391450", "url": "https://glygen.org/publication/PubMed/22391450" } ] }, { "title": "The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism.", "journal": "Molecular and cellular biology", "date": "2013", "authors": "Chen X, Muller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "23109430", "url": "https://glygen.org/publication/PubMed/23109430" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Novel interactions between FOXM1 and CDC25A regulate the cell cycle.", "journal": "PloS one", "date": "2012", "authors": "Sullivan C, Liu Y, Shen J, Curtis A, Newman C, Hock JM, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "23240008", "url": "https://glygen.org/publication/PubMed/23240008" } ] }, { "title": "B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.", "journal": "Cell death & disease", "date": "2013", "authors": "Werwein E, Dzuganova M, Usadel C, Klempnauer KH", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "23449447", "url": "https://glygen.org/publication/PubMed/23449447" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nat. Struct. Mol. Biol.", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.", "journal": "Nat. Commun.", "date": "2015", "authors": "Klein DK, Hoffmann S, Ahlskog JK, O'Hanlon K, Quaas M, Larsen BD, Rolland B, Rosner HI, Walter D, Kousholt AN, Menzel T, Lees M, Johansen JV, Rappsilber J, Engeland K, Sorensen CS", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "25557911", "url": "https://glygen.org/publication/PubMed/25557911" } ] }, { "title": "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.", "journal": "Cell Rep.", "date": "2015", "authors": "Hendriks Ivo A, Treffers Louise W, Verlaan-de Vries Matty, Olsen Jesper V, Vertegaal Alfred C O", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "25772364", "url": "https://glygen.org/publication/PubMed/25772364" } ] }, { "title": "Study of the S427G polymorphism and of MYBL2 variants in patients with acute myeloid leukemia.", "journal": "Leukemia & lymphoma", "date": "2016", "authors": "Dolz S, Garcia P, Llop M, Fuster O, Luna I, Ibanez M, Gomez I, Lopez M, Such E, Cervera J, Sanz MA, De Juan I, Palanca S, Murria R, Bolufer P, Barragan E", "evidence": [ { "database": "Entrez", "id": "4605", "url": "https://www.ncbi.nlm.nih.gov/gene/4605" } ], "reference": [ { "type": "PubMed", "id": "26014440", "url": "https://glygen.org/publication/PubMed/26014440" } ] }, { "title": "Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray.", "journal": "PloS one", "date": "2016", "authors": "Shi J, Sharif S, Ruijtenbeek R, Pieters RJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10244", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10244" } ], "reference": [ { "type": "PubMed", "id": "26960196", "url": "https://glygen.org/publication/PubMed/26960196" } ] }, { "title": "Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3beta implicate human B-Myb in DNA-damage signaling.", "journal": "Scientific reports", "date": "2017", "authors": "Henrich SM, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, Hess D, Klempnauer KH", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "28128338", "url": "https://glygen.org/publication/PubMed/28128338" } ] }, { "title": "The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb.", "journal": "Oncogene", "date": "2019", "authors": "Iness AN, Felthousen J, Ananthapadmanabhan V, Sesay F, Saini S, Guiley KZ, Rubin SM, Dozmorov M, Litovchick L", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "30206359", "url": "https://glygen.org/publication/PubMed/30206359" } ] }, { "title": "Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization.", "journal": "Nucleic acids research", "date": "2019", "authors": "Werwein E, Cibis H, Hess D, Klempnauer KH", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "30321399", "url": "https://glygen.org/publication/PubMed/30321399" } ] }, { "title": "Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.", "journal": "Nucleic Acids Res.", "date": "1988", "authors": "Nomura N, Takahashi M, Matsui M, Ishii S, Date T, Sasamoto S, Ishizaki R", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "3060855", "url": "https://glygen.org/publication/PubMed/3060855" } ] }, { "title": "Intramolecular interaction of B-MYB is regulated through Ser-577 phosphorylation.", "journal": "FEBS letters", "date": "2020-12", "authors": "Werwein Eugen, Biyanee Abhiruchi, Klempnauer Karl-Heinz", "evidence": [ { "database": "iPTMnet", "id": "P10244", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244" } ], "reference": [ { "type": "PubMed", "id": "32979888", "url": "https://glygen.org/publication/PubMed/32979888" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10244", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10244" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "[High expression of MYBL2 promotes progression and predicts a poor survival outcome of prostate cancer].", "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University", "date": "2022", "authors": "Yang M, Zhu X, Shen Y, He Q, Qin Y, Shao Y, Yuan L, Ye H", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" } ], "reference": [ { "type": "PubMed", "id": "36073208", "url": "https://glygen.org/publication/PubMed/36073208" } ] }, { "title": "MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells.", "journal": "BMC cancer", "date": "2022-12-09", "authors": "Zhao Jun-Zhang, Wang Wei, Liu Tao, Zhang Lei, Lin De-Zheng, Yao Jia-Yin, Peng Xiang, Jin Gang, Ma Tian-Tian, Gao Jin-Bo, Huang Fang, Nie Jun, Lv Qing", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" } ], "reference": [ { "type": "PubMed", "id": "36494680", "url": "https://glygen.org/publication/PubMed/36494680" } ] }, { "title": "Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer.", "journal": "Chemico-biological interactions", "date": "2023-04-01", "authors": "Liu Feng, Wang Yutingzi, Cao Yang, Wu Zhiwei, Ma De, Cai Jun, Sha Jie, Chen Qing", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" } ], "reference": [ { "type": "PubMed", "id": "36812959", "url": "https://glygen.org/publication/PubMed/36812959" } ] }, { "title": "Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.", "journal": "Cell death & disease", "date": "2023-02-28", "authors": "Brahim Sonia, Negulescu Ana-Maria, Geneste Clara, Schott Thomas, Lin Shuheng, Morel Louis-Oscar, Rama Nicolas, Gadot Nicolas, Treilleux Isabelle, Mehlen Patrick, Meurette Olivier", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" } ], "reference": [ { "type": "PubMed", "id": "36854682", "url": "https://glygen.org/publication/PubMed/36854682" } ] }, { "title": "Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer.", "journal": "Photodiagnosis and photodynamic therapy", "date": "2023-06", "authors": "Hui Yuan-Jian, Chen Hao, Peng Xing-Chun, Li Liu-Gen, Di Mao-Jun, Liu Hui, Hu Xu-Hao, Yang Yan, Zhao Kai-Liang, Li Tong-Fei, Yu Ting-Ting, Wang Wei-Xing", "evidence": [ { "database": "RefSeq", "id": "NP_001265539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265539" } ], "reference": [ { "type": "PubMed", "id": "37030434", "url": "https://glygen.org/publication/PubMed/37030434" } ] }, { "title": "Multiple nuclear localization signals of the B-myb gene product.", "journal": "FEBS Lett.", "date": "1994", "authors": "Takemoto Y, Tashiro S, Handa H, Ishii S", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" } ], "reference": [ { "type": "PubMed", "id": "8062924", "url": "https://glygen.org/publication/PubMed/8062924" } ] }, { "title": "Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.", "journal": "Science (New York, N.Y.)", "date": "1996", "authors": "Kumagai A, Dunphy WG", "evidence": [ { "database": "Reactome", "id": "R-HSA-156711", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711" } ], "reference": [ { "type": "PubMed", "id": "8703070", "url": "https://glygen.org/publication/PubMed/8703070" } ] }, { "title": "The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.", "journal": "Oncogene", "date": "1998", "authors": "Saville MK, Watson RJ", "evidence": [ { "database": "UniProtKB", "id": "P10244", "url": "https://www.uniprot.org/uniprot/P10244" }, { "database": "iPTMnet", "id": "P10244-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10244-1" } ], "reference": [ { "type": "PubMed", "id": "9840932", "url": "https://glygen.org/publication/PubMed/9840932" } ] } ], "pathway": [ { "id": "hsa:4605", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4605", "resource": "KEGG Pathway" }, { "id": "R-HSA-1362300", "name": "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1362300", "resource": "Reactome", "description": "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" }, { "id": "R-HSA-156711", "name": "Polo-like kinase mediated events", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156711", "resource": "Reactome", "description": "Polo-like kinase mediated events" }, { "id": "R-HSA-8869496", "name": "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8869496", "resource": "Reactome", "description": "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZLC6-1", "protein_name": "MYB proto-oncogene like 2", "gene_name": "Mybl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRRTRCEELDELRYQDTDSDLLEQRDNKCKVKWTHEEDELLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPNESRDCKPVYLLLELEDKDYQQNVQPVEGPGSLVSSWPLAPSTVKEEESSEEEAAVATTSKEHKQEPVPTDLGEVRTPEPLEFLKREYQEESSPETSLPYKWVVEAANLLIPAVESSLSEALDLIESDPDAWCDLSKFDLPEEPSAEGSVNSSPVQLQTPQQQQQHQQALSFHQAATPGPSVTEYRLDGHTISDLSRSSRGELIPISPSTEFGGSGIGTPPSVLKRQKKRRVALSPVTENSASLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKYPSFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDMRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDGKMMSSTSPKTLSLPTSVPSSSSGFILPGIKEDNSLLNQGFLQAKPEKVVATQKPRSHIPAPAPMTRAWKTVACGGTKDQLFMQEKARQLLGRLKSSHTSRTLILS", "length": 704 }, "evidence": [ { "id": "45917641", "url": "http://www.informatics.jax.org/homology/45917641", "database": "MGI" }, { "id": "P10244", "url": "https://omabrowser.org/oma/group/P10244/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P48972-1", "protein_name": "Myb-related protein B", "gene_name": "Mybl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRRTRCEDLDELHYQDVDSDLLEQRDNRCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRDCKPVYLLLELEDKEQHQGVQPVDGQGSLVSSWPLVPSIVKEESSEEEIAIAATSAKELGHEPVPADLGEVRTPEPPESLKREYQEFSSPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSTEGSVVSSPVQPQTSQQQQEEALQSSQQAATPGPSVTEYRLDGHTISDLSRSSRGELIPISPSTEFGGSGIGTPPSVLKRQKKRRVALSPVTENSASLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKYPSSEVLPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGMELIIEDDMRPEKQKRKPGLRRSPIKKVRKSLALDIMDEDGKLMSSTMPKPLSLPTSVTPSSCGFTSPGSKEGNSLLNQGFLQAKPEKVVAAQKTRSHIPTPAPMTHAWKTVACGGTKDQLFMQEKARQLLSRLKSSHTSRTLILS", "length": 704 }, "evidence": [ { "id": "45917641", "url": "http://www.informatics.jax.org/homology/45917641", "database": "MGI" }, { "id": "P10244", "url": 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