{ "uniprot_canonical_ac": "P0DTE5-1", "uniprot_ac": "P0DTE5", "uniprot_id": "UD2A2_HUMAN", "mass": { "chemical_mass": 60772.0, "monoisotopic_mass": 60772.0 }, "refseq": { "ac": "NP_001099147", "name": "UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i1 precursor", "summary": "The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A1 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147" }, "gene_names": [ { "name": "UGT2A2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P0DTE5", "id": "P0DTE5" }, { "name": "UDPGT 2A2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147", "id": "NP_001099147" }, { "name": "UGT2A2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147", "id": "NP_001099147" } ], "protein_names": [ { "name": "UDP-glucuronosyltransferase 2A2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P0DTE5" }, { "name": "2.4.1.17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0DTE5" }, { "name": "UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147", "id": "NP_001099147" }, { "name": "UDP-glucuronosyltransferase 2A2; UDP glucuronosyltransferase 2 family, polypeptide A2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147", "id": "NP_001099147" }, { "name": "UDPGT 2A2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0DTE5" } ], "function": [ { "annotation": "Results show that UGT2A2 not only shares exons 2-6 with UGT2A1, it also shares with it a similar tissue expression pattern; both UGTs are primarily expressed in nasal epithelium. The 3rd member of UGT2A subfamily, UGT2A3 exhibited a different tissue expression pattern, found mainly in liver and small intestine.", "evidence": [ { "database": "RefSeq", "id": "NP_001099147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147" }, { "database": "PubMed", "id": "19858781", "url": "https://glygen.org/publication/PubMed/19858781" } ] }, { "annotation": "The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.", "evidence": [ { "database": "RefSeq", "id": "NP_001099147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147" }, { "database": "PubMed", "id": "35039640", "url": "https://glygen.org/publication/PubMed/35039640" } ] }, { "annotation": "The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A1 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022].", "evidence": [ { "database": "RefSeq", "id": "NP_001099147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099147" } ] }, { "annotation": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:19858781, PubMed:18719240, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781).", "evidence": [ { "database": "UniProtKB", "id": "P0DTE5", "url": "https://www.uniprot.org/uniprot/P0DTE5#function" }, { "database": "PubMed", "id": "19858781", "url": "https://glygen.org/publication/PubMed/19858781" }, { "database": "PubMed", "id": "23288867", "url": "https://glygen.org/publication/PubMed/23288867" }, { "database": "PubMed", "id": "18719240", "url": "https://glygen.org/publication/PubMed/18719240" }, { "database": "PubMed", "id": "23756265", "url": "https://glygen.org/publication/PubMed/23756265" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1281070914", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1281070914" }, { "id": "rs1281070914", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1281070914" } ], "glycoeffect": [ "n-glyco-sequon-loss", "n-glyco-sequon-gain" ], "start_pos": 58, "end_pos": 58, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->SVT); n-glyco-sequon-gain (NHN->NHS).", "chr_id": "4", "chr_pos": "69639468", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N58", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P0DTE5", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P0DTE5" } ], "glycoeffect": [], "start_pos": 121, "end_pos": 121, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "G", "sequence_mut": "E", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "4", "chr_pos": "69639279", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "G121", "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1007029903", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1007029903" }, { "id": "rs1007029903", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1007029903#frequency_tab" }, { "id": "rs1007029903", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1007029903" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 223, "end_pos": 223, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTI->NTT).", "chr_id": "4", "chr_pos": "69638973", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I223", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778389564", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778389564" }, { "id": "rs778389564", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778389564" }, { "id": "rs778389564", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778389564" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 322, "end_pos": 322, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->DLT).", "chr_id": "4", "chr_pos": "69596309", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N322", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1302380884", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1302380884" }, { "id": "rs1302380884", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1302380884" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 322, "end_pos": 322, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->TLT).", "chr_id": "4", "chr_pos": "69596308", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N322", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1577946333", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1577946333" }, { "id": "rs1577946333", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1577946333" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 324, "end_pos": 324, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NLK).", "chr_id": "4", "chr_pos": "69596302", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T324", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs779696171", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779696171" }, { "id": "rs779696171", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779696171" }, { "id": "rs779696171", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs779696171#frequency_tab" }, { "id": "rs779696171", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs779696171" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 331, "end_pos": 331, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLI->NLT).", "chr_id": "4", "chr_pos": "69596281", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I331", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1470518850", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1470518850" }, { "id": "rs1470518850", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1470518850#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 33, "end_pos": 33, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVL->NVS).", "chr_id": "4", "chr_pos": "69639543", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L33", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs541627076", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs541627076" }, { "id": "rs541627076", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs541627076" }, { "id": "rs541627076", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs541627076" }, { "id": "rs541627076", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs541627076#frequency_tab" }, { "id": "rs541627076", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs541627076" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 356, "end_pos": 356, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNT->KNT).", "chr_id": "4", "chr_pos": "69595205", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "N356", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765655029", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765655029" }, { "id": "rs765655029", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765655029" }, { "id": "rs765655029", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765655029#frequency_tab" }, { "id": "rs765655029", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765655029" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 358, "end_pos": 358, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNT->NNI).", "chr_id": "4", "chr_pos": "69595200", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T358", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1470469921", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1470469921" }, { "id": "rs1470469921", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1470469921#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 387, "end_pos": 387, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGI->NGT).", "chr_id": "4", "chr_pos": "69594648", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I387", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P0DTE5", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P0DTE5" }, { "id": "rs1467701138", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1467701138" }, { "id": "rs1467701138", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1467701138#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 38, "end_pos": 38, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "4", "chr_pos": "69639529", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D38", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - 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"pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21032", "name": "", "equation": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08541-1", "P19488-1", "Q64638-1", "Q64550-1", "P08430-1", "P20720-1", "Q62789-1", "Q64633-1", "Q64634-1", "Q64637-1", "P08542-1", "P09875-1", "P36510-1", "P36511-1", "A0A0G2K727-1", "A0A0G2JW02-1", "F1LTB8-1", "F1M3E3-1", "P54855-1", "P16662-1", "Q3SY77-1", "O75310-1", "P19224-1", "Q6NUS8-1", "Q6UWM9-1", "P36537-1", "P06133-1", "Q9BY64-1", "Q9HAW7-1", "Q9HAW9-1", "Q9HAW8-1", "P35503-1", "P35504-1", "O60656-1", "O75795-1", "P22310-1", "P22309-1", "P0DTE5-1", "P0DTE4-5", "Q8JZZ0-1", "P70691-1", "Q3UP75-1", "Q8BWQ1-1", "P17717-1", "Q62452-1", "Q63886-1", "Q8R084-1", "Q8VCN3-1", "Q8BJL9-1", "Q8K154-1", "Q6PDD0-1", "Q80X89-1", "Q3UEP4-1", "Q64435-1", "Q6ZQM8-1", "D3Z748-1", "K9J7B2-1", "B2RT14-1", "Q9VDA5-1", "Q9VGT4-1", "Q9VGT5-1", "Q9VGS7-1", "Q9VJ46-1", "Q8SYL7-1", "Q9VJ45-1", "Q9W2J3-1", "Q9VJ81-1", "Q9VGT2-1", "Q9VGT8-1", "Q9W2J4-1", "Q9V9X9-1", "Q9VJ47-1", "Q9VGT0-1" ], "evidence": [ { "id": "21032", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21032" } ] }, { "id": "52460", "name": "", "equation": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64550-1", "Q64634-1", "Q64637-1", "P36510-1", "Q9HAW9-1", "Q9HAW8-1", "P35503-1", "P22309-1", "P0DTE5-1", "P0DTE4-5", "Q63886-1", "Q6PDD0-1", "Q80X89-1" ], "evidence": [ { "id": "52460", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52460" } ] }, { "id": "52868", "name": "", "equation": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64550-1", "P08542-1", "P36510-1", "Q64633-1", "Q64634-1", "Q64637-1", "P36511-1", "Q9HAW7-1", "Q9HAW9-1", "Q9HAW8-1", "P35503-1", "O75795-1", "P22309-1", "P54855-1", "P0DTE5-1", "P0DTE4-5", "Q63886-1", "Q6PDD0-1", "Q80X89-1", "P17717-1", "Q6ZQM8-1" ], "evidence": [ { "id": "52868", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52868" } ] }, { "id": "52940", "name": "", "equation": "chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64637-1", "P35503-1", "P0DTE5-1", "Q6PDD0-1" ], "evidence": [ { "id": "52940", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52940" } ] }, { "id": "52948", "name": "", "equation": "deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64637-1", "P36510-1", "P35503-1", "P0DTE5-1", "P0DTE4-5", "Q6PDD0-1", "Q80X89-1" ], "evidence": [ { "id": "52948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52948" } ] }, { "id": "52952", "name": "", "equation": "lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64637-1", "P36510-1", "P35503-1", "P0DTE5-1", "P0DTE4-5", "Q6PDD0-1", "Q80X89-1" ], "evidence": [ { "id": "52952", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52952" } ] }, { "id": "52960", "name": "", "equation": "hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64637-1", "P36510-1", "P35503-1", "P0DTE5-1", "P0DTE4-5", "Q6PDD0-1", "Q80X89-1" ], "evidence": [ { "id": "52960", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52960" } ] }, { "id": "52964", "name": "", "equation": "hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62789-1", "P36510-1", "P16662-1", "P0DTE5-1", "Q6PDD0-1", "Q80X89-1" ], "evidence": [ { "id": "52964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52964" } ] }, { "id": "R-HSA-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "equation": "", "summary": "Typical O-centred substrates were chosen as examples for these isozymes. Many UDP-glucuronosyltransferases (UGTs) can transfer the glucuronyl moiety (GlcA) from UDP-GlcA to the O-centre functional group of many substrates, including salicylate (ST), to form 4-O-glucuronides (Casarett & Doull 1995, Babu et al. 1996; Kuehl et al, 2006).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16662-1", "Q3SY77-1", "Q6UWM9-1", "Q9BY64-1", "P0DTE5-1", "P06133-1", "P22310-1", "P35503-1", "Q9HAW7-1", "Q9HAW9-1", "O60656-1", "O75310-1", "O75795-1", "P19224-1", "P22309-1", "P35504-1", "P36537-1", "P54855-1", "Q6NUS8-1", "P0DTE4-5" ], "evidence": [ { "id": "R-HSA-174931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174931" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JW02", "gene_name": "Ugt2a3", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "A0A0G2JW02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW02" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "A0A0G2JW02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW02" } ] } ] }, { "uniprot_ac": "A0A0G2K727", "gene_name": "ENSRNOG00000065137", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "A0A0G2K727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K727" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "A0A0G2K727", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K727" } ] } ] }, { "uniprot_ac": "B2RT14", "gene_name": "Ugt1a5", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "B2RT14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RT14" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "B2RT14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RT14" } ] } ] }, { "uniprot_ac": "D3Z748", "gene_name": "Ugt1a8", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "D3Z748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z748" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "D3Z748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z748" } ] } ] }, { "uniprot_ac": "F1LTB8", "gene_name": "RGD1559459", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "F1LTB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTB8" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "F1LTB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTB8" } ] } ] }, { "uniprot_ac": "F1M3E3", "gene_name": "AC114845.1", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "F1M3E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3E3" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "F1M3E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3E3" } ] } ] }, { "uniprot_ac": "K9J7B2", "gene_name": "Ugt1a6b", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "K9J7B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/K9J7B2" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "K9J7B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/K9J7B2" } ] } ] }, { "uniprot_ac": "O60656", "gene_name": "UGT1A9", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "O60656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60656" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "O60656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60656" } ] } ] }, { "uniprot_ac": "O75310", "gene_name": "UGT2B11", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "O75310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75310" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "O75310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75310" } ] } ] }, { "uniprot_ac": "O75795", "gene_name": "UGT2B17", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "O75795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75795" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "O75795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75795" } ] } ] }, { "uniprot_ac": "P06133", "gene_name": "UGT2B4", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P06133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06133" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P06133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06133" } ] } ] }, { "uniprot_ac": "P08430", "gene_name": "Ugt1a6", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P08430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08430" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P08430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08430" } ] } ] }, { "uniprot_ac": "P08541", "gene_name": "Ugt2b", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P08541", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08541" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P08541", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08541" } ] } ] }, { "uniprot_ac": "P08542", "gene_name": "Ugt2b17", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P08542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08542" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P08542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08542" } ] } ] }, { "uniprot_ac": "P09875", "gene_name": "Ugt2b1", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P09875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09875" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P09875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09875" } ] } ] }, { "uniprot_ac": "P0DTE4", "gene_name": "UGT2A1", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P0DTE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DTE4" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P0DTE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DTE4" } ] } ] }, { "uniprot_ac": "P0DTE5", "gene_name": "UGT2A2", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P0DTE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DTE5" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P0DTE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DTE5" } ] } ] }, { "uniprot_ac": "P16662", "gene_name": "UGT2B7", "activity": [ { 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UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P19224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19224" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P19224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19224" } ] } ] }, { "uniprot_ac": "P19488", "gene_name": "Ugt2b37", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP.", "evidence": [ { "id": "P19488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19488" } ] }, { "ec_number": "2.4.1.17", "activity": "", "evidence": [ { "id": "P19488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19488" } ] } ] }, { "uniprot_ac": "P20720", "gene_name": "Ugt1a2", "activity": [ { "ec_number": "2.4.1.17", "activity": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + 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