{ "uniprot_canonical_ac": "P0CT32-1", "uniprot_ac": "P0CT32", "uniprot_id": "EF1A2_DICDI", "mass": { "chemical_mass": 49662.0, "monoisotopic_mass": 49662.0 }, "refseq": { "ac": "XP_645839", "name": "elongation factor 1 alpha", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645839" }, "gene_names": [ { "name": "eef1a2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P0CT32", "id": "P0CT32" }, { "name": "DDB_G0269136", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P0CT32", "id": "P0CT32" }, { "name": "efaAII", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P0CT32", "id": "P0CT32" }, { "name": "efaa2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P0CT32", "id": "P0CT32" } ], "protein_names": [ { "name": "Elongation factor 1-alpha", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P0CT32" }, { "name": "50 kDa actin-binding protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0CT32" }, { "name": "ABP-50", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0CT32" }, { "name": "EF-1-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0CT32" }, { "name": "elongation factor 1 alpha", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645839", "id": "XP_645839" }, { "name": "elongation factor 1a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645839", "id": "XP_645839" } ], "function": [ { "annotation": "This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. It is also an abundant actin filament bundling protein.", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "eef1a2", "url": "https://www.uniprot.org/uniprot/P0CT32", "locus": {} } ], "crossref": [ { "id": "cd01883", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01883", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03693", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03693", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0269136", "url": "http://dictybase.org/gene/DDB_G0269136", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8616783", "url": "https://www.ncbi.nlm.nih.gov/gene/8616783", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8616922", "url": "https://www.ncbi.nlm.nih.gov/gene/8616922", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0269134", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0269134", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ddi:DDB_G0269136", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0269136", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AIRDMGM", "url": "https://omabrowser.org/oma/group/AIRDMGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23115:SF170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115:SF170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "http://pfam.xfam.org/family/PF00009", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03143", "url": "http://pfam.xfam.org/family/PF03143", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03144", "url": "http://pfam.xfam.org/family/PF03144", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P0CT32", "url": "http://purl.obolibrary.org/obo/PR_P0CT32", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-156842", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-156842", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-3371511", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-3371511", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-8876725", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8876725", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_645839", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645839", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0CT32-1", "url": "https://www.uniprot.org/uniprot/P0CT32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKEKTHINIVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKYEKEASEMGKQSFKYAWVMDKLKAERERGITIDIALWKFETSKYYFTIIDAPGHRDFIKNMITGTSQADCAVLVIASPTGEFEAGIAKNGQTREHALLAYTLGVKQMIVAINKMDEKSTNYSQARYDEIVKEVSSFIKKIGYNPEKVAFVPISGWNGDNMLERSDKMEWYKGPTLLEALDAIVEPKRPHDKPLRIPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPAGLSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSVKEIKRGMVAGDSKNDPPQETEKFVAQVIVLNHPGQIHAGYSPVLDCHTAHIACKFTEIVDKVDRRTGAVVAKEGTAAVVLKNGDAAMVELTPSRPMCVESFTEYPPLGRFAVRDMRQTVAVGVIKSTVKKAPGKAGDKKGAAAPSKKK", "length": 453, "header": "sp|P0CT32-1|EF1A2_DICDI Isoform 1 of Elongation factor 1-alpha OS=Dictyostelium discoideum OX=44689 GN=eef1a2 PE=1 SV=1 CANONICAL=P0CT32-1" }, "isoforms": [ { "isoform_ac": "P0CT32-1", "url": "", "sequence": { "sequence": "MGKEKTHINIVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKYEKEASEMGKQSFKYAWVMDKLKAERERGITIDIALWKFETSKYYFTIIDAPGHRDFIKNMITGTSQADCAVLVIASPTGEFEAGIAKNGQTREHALLAYTLGVKQMIVAINKMDEKSTNYSQARYDEIVKEVSSFIKKIGYNPEKVAFVPISGWNGDNMLERSDKMEWYKGPTLLEALDAIVEPKRPHDKPLRIPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPAGLSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSVKEIKRGMVAGDSKNDPPQETEKFVAQVIVLNHPGQIHAGYSPVLDCHTAHIACKFTEIVDKVDRRTGAVVAKEGTAAVVLKNGDAAMVELTPSRPMCVESFTEYPPLGRFAVRDMRQTVAVGVIKSTVKKAPGKAGDKKGAAAPSKKK", "length": 453, "header": "sp|P0CT32-1|EF1A2_DICDI Isoform 1 of Elongation factor 1-alpha OS=Dictyostelium discoideum OX=44689 GN=eef1a2 PE=1 SV=1 CANONICAL=P0CT32-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake.", "journal": "Mol. Cell. Proteomics", "date": "2006", "authors": "Gotthardt Daniel, Blancheteau Vincent, Bosserhoff Armin, Ruppert Thomas, Delorenzi Mauro, Soldati Thierry", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "reference": [ { "type": "PubMed", "id": "16926386", "url": "https://glygen.org/publication/PubMed/16926386" } ] }, { "title": "Identification of an actin-binding protein from Dictyostelium as elongation factor 1a.", "journal": "Nature", "date": "1990", "authors": "Yang F, Demma M, Warren V, Dharmawardhane S, Condeelis J", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "reference": [ { "type": "PubMed", "id": "2215665", "url": "https://glygen.org/publication/PubMed/2215665" } ] } ], "pathway": [ { "id": "ddi:DDB_G0269134", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0269134", "resource": "KEGG Pathway" }, { "id": "ddi:DDB_G0269136", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0269136", "resource": "KEGG Pathway" }, { "id": "R-DDI-156842", "name": "Eukaryotic Translation Elongation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-156842", "resource": "Reactome", "description": "Eukaryotic Translation Elongation" }, { "id": "R-DDI-3371511", "name": "HSF1 activation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-3371511", "resource": "Reactome", "description": "HSF1 activation" }, { "id": "R-DDI-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-DDI-8876725", "name": "Protein methylation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8876725", "resource": "Reactome", "description": "Protein methylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "pseudopodium", "id": "GO:0031143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031143", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "response to alkaline pH", "id": "GO:0010446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010446", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "actin filament bundle assembly", "id": "GO:0051017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" }, { "name": "translational elongation", "id": "GO:0006414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006414", "evidence": [ { "database": "UniProtKB", "id": "P0CT32", "url": "https://www.uniprot.org/uniprot/P0CT32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 302, "end_pos": 304 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }