{ "uniprot_canonical_ac": "P0CG88-1", "uniprot_ac": "P0CG88", "uniprot_id": "UBIQJ_DICDI", "mass": { "chemical_mass": 34211.0, "monoisotopic_mass": 34211.0 }, "refseq": { "ac": "XP_629924", "name": "hypothetical protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629924" }, "gene_names": [ { "name": "ubqJ", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P0CG88", "id": "P0CG88" }, { "name": "DDB_G0269458", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P0CG88", "id": "P0CG88" }, { "name": "ubqI", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629924", "id": "XP_629924" } ], "protein_names": [ { "name": "Polyubiquitin-J", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P0CG88" }, { "name": "hypothetical protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629924", "id": "XP_629924" } ], "function": [ { "annotation": "Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P0CG88", "url": "https://www.uniprot.org/uniprot/P0CG88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P0CG88", "url": "https://www.uniprot.org/uniprot/P0CG88" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "ubqJ", "url": "https://www.uniprot.org/uniprot/P0CG88", "locus": {} } ], "crossref": [ { "id": "cd01803", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01803", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0269458", "url": "http://dictybase.org/gene/DDB_G0269458", "database": "dictyBase", "categories": [ 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"https://www.reactome.org/PathwayBrowser/#R-DDI-9020702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9033241", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-917729", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-917937", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-917937", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-936440", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-936440", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9646399", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9646399", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9664873", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9664873", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9755511", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9758274", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9758274", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_629924", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629924", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P0CG88", "url": "https://www.uniprot.org/uniprot/P0CG88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0CG88-1", "url": "https://www.uniprot.org/uniprot/P0CG88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN", "length": 305, "header": "sp|P0CG88-1|UBIQJ_DICDI Isoform 1 of Polyubiquitin-J OS=Dictyostelium discoideum OX=44689 GN=ubqJ PE=1 SV=1 CANONICAL=P0CG88-1" }, "isoforms": [ { "isoform_ac": "P0CG88-1", "url": "", "sequence": { "sequence": "MQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN", "length": 305, "header": "sp|P0CG88-1|UBIQJ_DICDI Isoform 1 of Polyubiquitin-J OS=Dictyostelium discoideum OX=44689 GN=ubqJ PE=1 SV=1 CANONICAL=P0CG88-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P0CG88", "url": "https://www.uniprot.org/uniprot/P0CG88" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Identification of novel centrosomal proteins in Dictyostelium discoideum by comparative proteomic approaches.", "journal": "J. 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