{ "uniprot_canonical_ac": "P0CD65-1", "uniprot_ac": "P0CD65", "uniprot_id": "PAN3_DICDI", "mass": { "chemical_mass": 86441.0, "monoisotopic_mass": 86441.0 }, "refseq": {}, "gene_names": [ { "name": "pan3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P0CD65", "id": "P0CD65" }, { "name": "DDB_G0279129", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P0CD65", "id": "P0CD65" } ], "protein_names": [ { "name": "PAN2-PAN3 deadenylation complex subunit pan3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P0CD65" }, { "name": "PAB1P-dependent poly(A)-specific ribonuclease", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0CD65" }, { "name": "PAN deadenylation complex subunit 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0CD65" }, { "name": "Poly(A)-nuclease deadenylation complex subunit 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0CD65" } ], "function": [ { "annotation": "Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP.", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65#function" }, { "database": "UniProtKB", "id": "MF_03181", "url": "https://www.uniprot.org/uniprot/MF_03181#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "pan3", "url": "https://www.uniprot.org/uniprot/P0CD65", "locus": {} } ], "crossref": [ { "id": "DDB_G0279129", "url": "http://dictybase.org/gene/DDB_G0279129", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TWRNIQH", "url": "https://omabrowser.org/oma/group/TWRNIQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12272", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12272", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12272:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12272:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "http://pfam.xfam.org/family/PF00069", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18101", "url": "http://pfam.xfam.org/family/PF18101", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P0CD65", "url": "http://purl.obolibrary.org/obo/PR_P0CD65", "database": "PRO", "categories": [ "Protein" ] }, { "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0CD65-1", "url": "https://www.uniprot.org/uniprot/P0CD65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMYQQQPKNQKQCKNIALHGYCRNSDKCEFSHELTPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNSNGNGSNNTATSNNPIISPNSNIASPLKKSPIDNLTTSFQNLSTNQQTNHHWADHFQSGIPEYIPKQQLQQLQQQQLLQQQQQQALLLQQQQQQNYDDDQHLYPYGDNSVDDYEQHQYEPQPQPNNGIDPNMNNQFQINNFVAAQMRNASPQSYQQQFQQPNPSPQSSSQQQQQQQQQQQQAVYQQQQQQQPSSQPLAQNPSLQNNNNKLLQLQLQQHLQQIQAAQQQAQINQSYTPYPSYSQSVIRNKPGRRNIGSFFMSESLKQDILNQKSLLYLTLDPNDPRIKNIPPMLNKYHSLYPLDHDASRENQGKMFGYITSVYKAISTLDGLPYAIRRVEGFRLSSEYALQAAETWRNIQHPNIVSLKEIFVSKEFGDNSSLFFTYEFFPGSETLESKYLSQSGNPLSESVLWSFICQITSALKTIHSAGLVCRVIHPSKILLTGKNRIRMNGVGIFDVVNFDTPRILAQYQHEDLLLFGRLILTLACRSAQSTTTTNLSKSIEYVSNQYSKELYNLIVYLLTKPVINLPNIDEVVLMISGRLLQENNYLHTYTDDLETELSKEYENGRLFRLVTKLGFINERPLYDMDPRWSETGDRYLIKLFRDYIFHQVYDDGTPVLDFYHVVETLNKLDCGVDEKILLMSRDEQSLLVVSYKDLKKCIDSAFSELVSQKSHI", "length": 746, "header": "sp|P0CD65-1|PAN3_DICDI Isoform 1 of PAN2-PAN3 deadenylation complex subunit pan3 OS=Dictyostelium discoideum OX=44689 GN=pan3 PE=3 SV=1 CANONICAL=P0CD65-1" }, "isoforms": [ { "isoform_ac": "P0CD65-1", "url": "", "sequence": { "sequence": "MMYQQQPKNQKQCKNIALHGYCRNSDKCEFSHELTPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNSNGNGSNNTATSNNPIISPNSNIASPLKKSPIDNLTTSFQNLSTNQQTNHHWADHFQSGIPEYIPKQQLQQLQQQQLLQQQQQQALLLQQQQQQNYDDDQHLYPYGDNSVDDYEQHQYEPQPQPNNGIDPNMNNQFQINNFVAAQMRNASPQSYQQQFQQPNPSPQSSSQQQQQQQQQQQQAVYQQQQQQQPSSQPLAQNPSLQNNNNKLLQLQLQQHLQQIQAAQQQAQINQSYTPYPSYSQSVIRNKPGRRNIGSFFMSESLKQDILNQKSLLYLTLDPNDPRIKNIPPMLNKYHSLYPLDHDASRENQGKMFGYITSVYKAISTLDGLPYAIRRVEGFRLSSEYALQAAETWRNIQHPNIVSLKEIFVSKEFGDNSSLFFTYEFFPGSETLESKYLSQSGNPLSESVLWSFICQITSALKTIHSAGLVCRVIHPSKILLTGKNRIRMNGVGIFDVVNFDTPRILAQYQHEDLLLFGRLILTLACRSAQSTTTTNLSKSIEYVSNQYSKELYNLIVYLLTKPVINLPNIDEVVLMISGRLLQENNYLHTYTDDLETELSKEYENGRLFRLVTKLGFINERPLYDMDPRWSETGDRYLIKLFRDYIFHQVYDDGTPVLDFYHVVETLNKLDCGVDEKILLMSRDEQSLLVVSYKDLKKCIDSAFSELVSQKSHI", "length": 746, "header": "sp|P0CD65-1|PAN3_DICDI Isoform 1 of PAN2-PAN3 deadenylation complex subunit pan3 OS=Dictyostelium discoideum OX=44689 GN=pan3 PE=3 SV=1 CANONICAL=P0CD65-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA poly(A) tail shortening", "id": "GO:0000289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000289", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" }, { "name": "PAN complex", "id": "GO:0031251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031251", "evidence": [ { "database": "UniProtKB", "id": "P0CD65", "url": "https://www.uniprot.org/uniprot/P0CD65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 568, "end_pos": 570, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 112, "end_pos": 114 }, { "start_pos": 219, "end_pos": 221 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 568, "end_pos": 570 }, { "start_pos": 75, "end_pos": 77 }, { "start_pos": 78, "end_pos": 80 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }