{ "uniprot_canonical_ac": "P0C869-1", "uniprot_ac": "P0C869", "uniprot_id": "PA24B_HUMAN", "mass": { "chemical_mass": 87978.0, "monoisotopic_mass": 87978.0 }, "refseq": { "ac": "NP_001108105", "name": "cytosolic phospholipase A2 beta", "summary": "This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105" }, "gene_names": [ { "name": "PLA2G4B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P0C869", "id": "P0C869" }, { "name": "PLA2G4B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105", "id": "NP_001108105" }, { "name": "cPLA2-beta; HsT16992", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105", "id": "NP_001108105" } ], "protein_names": [ { "name": "Cytosolic phospholipase A2 beta", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P0C869" }, { "name": "3.1.1.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0C869" }, { "name": "3.1.1.5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0C869" }, { "name": "Lysophospholipase A1 group IVB", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0C869" }, { "name": "Phospholipase A2 group IVB", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0C869" }, { "name": "cPLA2-beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P0C869" }, { "name": "cytosolic phospholipase A2 beta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105", "id": "NP_001108105" }, { "name": "phospholipase A2, group IVB (cytosolic); lysophospholipase A1 group IVB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105", "id": "NP_001108105" } ], "function": [ { "annotation": "Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869#function" }, { "database": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" }, { "database": "PubMed", "id": "10358058", "url": "https://glygen.org/publication/PubMed/10358058" }, { "database": "PubMed", "id": "16617059", "url": "https://glygen.org/publication/PubMed/16617059" } ] }, { "annotation": "Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869#function" }, { "database": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" }, { "database": "PubMed", "id": "10358058", "url": "https://glygen.org/publication/PubMed/10358058" }, { "database": "PubMed", "id": "16617059", "url": "https://glygen.org/publication/PubMed/16617059" } ] }, { "annotation": "Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869#function" }, { "database": "PubMed", "id": "16617059", "url": "https://glygen.org/publication/PubMed/16617059" } ] }, { "annotation": "JMJD7-PLA2G4B may serve as an important therapeutic target and prognostic marker for head and neck squamous cell carcinoma development and progression.", "evidence": [ { "database": "RefSeq", "id": "NP_001108105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105" }, { "database": "PubMed", "id": "28030848", "url": "https://glygen.org/publication/PubMed/28030848" } ] }, { "annotation": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001108105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105" }, { "database": "PubMed", "id": "20628086", "url": "https://glygen.org/publication/PubMed/20628086" }, { "database": "PubMed", "id": "20056178", "url": "https://glygen.org/publication/PubMed/20056178" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001108105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105" }, { "database": "PubMed", "id": "19913121", "url": "https://glygen.org/publication/PubMed/19913121" } ] }, { "annotation": "TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses", "evidence": [ { "database": "RefSeq", "id": "NP_001108105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105" }, { "database": "PubMed", "id": "20167866", "url": "https://glygen.org/publication/PubMed/20167866" } ] }, { "annotation": "This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001108105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108105" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 335, "end_pos": 335, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869" }, { "database": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" } ] }, { "start_pos": 417, "end_pos": 417, "sequence_org": "H", "sequence_mut": "A", "comment": "No effect.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869" }, { "database": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" } ] }, { "start_pos": 615, "end_pos": 615, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869" }, { "database": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" } ] }, { "start_pos": 632, "end_pos": 632, "sequence_org": "R", "sequence_mut": "A", "comment": "Abolishes enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869" }, { "database": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "82.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "16.41", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "66.39", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "69.7", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "77.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "80.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "64.43", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "79.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "74.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243708", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243708" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P0C869", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P0C869" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P0C869", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P0C869" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P0C869", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P0C869" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P0C869" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P0C869", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P0C869" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P0C869" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"https://www.uniprot.org/uniprot/H3BSX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0C869-1", "url": "https://www.uniprot.org/uniprot/P0C869-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0C869-4", "url": "https://www.uniprot.org/uniprot/P0C869-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0C869-6", "url": "https://www.uniprot.org/uniprot/P0C869-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0C869-7", "url": "https://www.uniprot.org/uniprot/P0C869-7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0C869-8", "url": "https://www.uniprot.org/uniprot/P0C869-8", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH", "length": 781, "header": "sp|P0C869-1|PA24B_HUMAN Isoform 1 of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=2 CANONICAL=P0C869-1" }, "isoforms": [ { "isoform_ac": "H3BSX5-1", "url": "", "sequence": { "sequence": "XSLDYNLHGAFQLLEALRQAVQRRRQRRPH", "length": 30, "header": "tr|H3BSX5-1|PA24B_HUMAN Computationally mapped isoform of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=1 CANONICAL=P0C869-1" }, "locus": { "chromosome": "15", "start_pos": 41847858, "end_pos": 41846801, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569354.1", "url": "https://www.ensembl.org/id/ENST00000569354.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000456919.1", "url": "https://www.ensembl.org/id/ENSP00000456919.1" } ] } }, { "isoform_ac": "P0C869-1", "url": "", "sequence": { "sequence": "MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH", "length": 781, "header": "sp|P0C869-1|PA24B_HUMAN Isoform 1 of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=2 CANONICAL=P0C869-1" }, "locus": { "chromosome": "15", "start_pos": 41847857, "end_pos": 41838914, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452633.5", "url": "https://www.ensembl.org/id/ENST00000452633.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000396045.1", "url": "https://www.ensembl.org/id/ENSP00000396045.1" } ] } }, { "isoform_ac": "P0C869-4", "url": "", "sequence": { "sequence": "MATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH", "length": 482, "header": "sp|P0C869-4|PA24B_HUMAN Isoform 4 of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=2 CANONICAL=P0C869-1" }, "locus": {} }, { "isoform_ac": "P0C869-6", "url": "", "sequence": { "sequence": "MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH", "length": 1012, "header": "sp|P0C869-6|PA24B_HUMAN Isoform 6 of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=2 CANONICAL=P0C869-1" }, "locus": {} }, { "isoform_ac": "P0C869-7", "url": "", "sequence": { "sequence": "MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQGSGGHPRRRQLGR", "length": 893, "header": "sp|P0C869-7|PA24B_HUMAN Isoform 7 of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=2 CANONICAL=P0C869-1" }, "locus": {} }, { "isoform_ac": "P0C869-8", "url": "", "sequence": { "sequence": "MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLEALRQAVQRRRQRRPH", "length": 887, "header": "sp|P0C869-8|PA24B_HUMAN Isoform 8 of Cytosolic phospholipase A2 beta OS=Homo sapiens OX=9606 GN=PLA2G4B PE=1 SV=2 CANONICAL=P0C869-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Pickard RT, Strifler BA, Kramer RM, Sharp JD", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869" }, { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" } ] }, { "title": "Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1483115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1483115" } ], "reference": [ { "type": "PubMed", "id": "10092508", "url": "https://glygen.org/publication/PubMed/10092508" } ] }, { "title": "Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Ma Z, Wang X, Nowatzke W, Ramanadham S, Turk J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "10092647", "url": "https://glygen.org/publication/PubMed/10092647" } ] }, { "title": "An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Nagai Y, Aoki J, Sato T, Amano K, Matsuda Y, Arai H, Inoue K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482801" } ], "reference": [ { "type": "PubMed", "id": "10196188", "url": "https://glygen.org/publication/PubMed/10196188" } ] }, { "title": "The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene.", "journal": "European journal of biochemistry", "date": "1999", "authors": "Larsson Forsell PK, Kennedy BP, Claesson HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "10336645", "url": "https://glygen.org/publication/PubMed/10336645" } ] }, { "title": "Molecular characterization of cytosolic phospholipase A2-beta.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Song C, Chang XJ, Bean KM, Proia MS, Knopf JL, Kriz RW", "evidence": [ { "database": "UniProtKB", "id": "P0C869", "url": "https://www.uniprot.org/uniprot/P0C869" }, { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "10358058", "url": "https://glygen.org/publication/PubMed/10358058" } ] }, { "title": "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482925", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482925" } ], "reference": [ { "type": "PubMed", "id": "10455175", "url": "https://glygen.org/publication/PubMed/10455175" } ] }, { "title": "Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Hiroyama M, Takenawa T", "evidence": [ { "database": "Reactome", "id": "R-HSA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1483166" } ], "reference": [ { "type": "PubMed", "id": "10506173", "url": "https://glygen.org/publication/PubMed/10506173" } ] }, { "title": "Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.", "journal": "Journal of lipid research", "date": "1999", "authors": "de Vet EC, Ijlst L, Oostheim W, Dekker C, Moser HW, van Den Bosch H, Wanders RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1483166" } ], "reference": [ { "type": "PubMed", "id": "10553003", "url": "https://glygen.org/publication/PubMed/10553003" } ] }, { "title": "Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M", "evidence": [ { "database": "Reactome", "id": "R-HSA-381038", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381038" } ], "reference": [ { "type": "PubMed", "id": "10601334", "url": "https://glygen.org/publication/PubMed/10601334" } ] }, { "title": "Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Suzuki N, Ishizaki J, Yokota Y, Higashino K, Ono T, Ikeda M, Fujii N, Kawamoto K, Hanasaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482925", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482925" } ], "reference": [ { "type": "PubMed", "id": "10681567", "url": "https://glygen.org/publication/PubMed/10681567" } ] }, { "title": "HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Yu M, Haslam RH, Haslam DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-381038", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381038" } ], "reference": [ { "type": "PubMed", "id": "10827079", "url": "https://glygen.org/publication/PubMed/10827079" } ] }, { "title": "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482925", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482925" } ], "reference": [ { "type": "PubMed", "id": "11031251", "url": "https://glygen.org/publication/PubMed/11031251" } ] }, { "title": "Cloning and recombinant expression of human group IIF-secreted phospholipase A(2).", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Valentin E, Singer AG, Ghomashchi F, Lazdunski M, Gelb MH, Lambeau G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482925", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482925" } ], "reference": [ { "type": "PubMed", "id": "11112443", "url": "https://glygen.org/publication/PubMed/11112443" } ] }, { "title": "A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Nakajima K, Sonoda H, Mizoguchi T, Aoki J, Arai H, Nagahama M, Tagaya M, Tani K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1483166" } ], "reference": [ { "type": "PubMed", "id": "11788596", "url": "https://glygen.org/publication/PubMed/11788596" } ] }, { "title": "Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Hiraoka M, Abe A, Shayman JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-1483115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1483115" } ], "reference": [ { "type": "PubMed", "id": "11790796", "url": "https://glygen.org/publication/PubMed/11790796" } ] }, { "title": "Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2.", "journal": "The Journal of biological 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{ "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 726, "end_pos": 728, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54728-1", "O88202-1", "P50393-1", "P97570-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "D3ZRC4-1", "P47712-1", "Q86U10-1", "Q6P1J6-1", "Q9NP80-1", "Q8IY17-4", "P0C869-1", "P11150-1", "O60733-1", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "A0JNU3-1", "Q8K1N1-1", "P47713-1", "Q3TRM4-1", "Q3TTY0-1", "P0C871-1", "Q8VEB4-1", "A2AJ88-1", "P97819-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q04958-1", "Q08108-1", "Q9U969-1", "Q9VMM8-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "15801", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "P39878-1", "O54728-1", "P04055-1", "P50393-1", "P53817-1", "P51433-1", "Q9QZT3-1", "P14423-1", "O35244-1", "D3Z9B7-1", "D3ZLB5-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "D3ZRC4-1", "Q675A5-1", "D2KX21-1", "Q4KLN5-1", "F7F420-1", "P0C548-1", "P0C869-1", "Q9BZM1-1", "Q8WU67-1", "P14555-1", "P04054-1", "Q9HDD0-1", "Q9UL19-1", "Q9NWW9-1", "Q96KN8-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "Q3MJ16-3", "Q9BZM2-1", "P53816-1", "O15496-1", "O60733-1", "Q6P1J6-1", "Q9UNK4-1", "P30041-1", "Q86XP0-1", "Q9UP65-1", "P39877-1", "Q9NZK7-1", "Q5R387-1", "Q9HCN3-1", "Q8NCC3-1", "Q9NP80-1", "Q9NST1-1", "Q96AD5-1", "P41247-1", "P0C871-1", "O08709-1", "Q91ZH7-1", "Q9CPX5-1", "Q9QZU4-1", "Q8R3U1-1", "P31482-1", "P47713-1", "Q9WVF6-1", "Q9Z0Y2-1", "P48076-1", "Q9EPR2-1", "P97391-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q50L43-1", "Q3TTY0-1", "Q64GA5-1", "Q9QUL3-1", "Q9QXX3-1", "Q9QZT4-1", "Q9ESN3-1", "Q8K1N1-1", "Q8VEB4-1", "Q8BZT7-1", "Q91WW7-1", "Q8BJ56-1", "Q8BG37-1", "Q08448-1", "Q7KUD4-1", "Q8IML0-1", "Q9VMM8-1" ], "evidence": [ { "id": "15801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15801" } ] }, { "id": "40427", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "D3ZRC4-1", "P04055-1", "P50393-1", "P18424-1", "P51433-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "P53816-1", "Q86XP0-1", "P0C869-1", "P04180-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "P04054-1", "Q3MJ16-3", "Q9UP65-1", "P39877-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q8R3U1-1", "Q50L43-1", "Q8K1N1-1", "Q9Z0Y2-1", "P97391-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q8BZT7-1", "P16301-1", "Q64GA5-1" ], "evidence": [ { "id": "40427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40427" } ] }, { "id": "40431", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "P51433-1", "P14423-1", "D2KX21-1", "D3ZRC4-1", "Q9HDD0-1", "Q9NWW9-1", "P53816-1", "Q86XP0-1", "P0C869-1", "Q9BZM2-1", "O60733-1", "Q68DD2-1", "Q9NZ20-1", "P14555-1", "P39877-1", "Q9NZK7-1", "Q9NP80-1", "Q9QZU4-1", "Q8R3U1-1", "Q50L43-1", "Q9QZT4-1", "Q8K1N1-1", "P31482-1", "P97391-1", "P97819-1", "Q50L41-1", "Q9QUL3-1", "Q8BZT7-1" ], "evidence": [ { "id": "40431", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40431" } ] }, { "id": "40435", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "O88202-1", "P97570-1", "O54728-1", "P50393-1", "P70470-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "Q9QYL8-1", "D3ZRC4-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "D4A328-1", "P19835-1", "Q86U10-1", "P0C869-1", "Q6P1J6-1", "P11150-1", "Q7L5L3-2", "O95372-1", "O75608-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q3MJ16-3", "Q8IY17-4", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q64285-1", "A0JNU3-1", "Q50L43-1", "Q9WTL7-1", "P97823-1", "Q8VEB4-1", "Q8K1N1-1", "A2AJ88-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q3TRM4-1", "Q3TTY0-1", "Q99LY2-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q9VMM8-1" ], "evidence": [ { "id": "40435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40435" } ] }, { "id": "40571", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "D3ZRC4-1", "Q9UL19-1", "Q9NWW9-1", "P53816-1", "P0C869-1", "Q9UP65-1", "Q9NP80-1", "Q8R3U1-1", "Q8K1N1-1", "Q64GA5-1" ], "evidence": [ { "id": "40571", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40571" } ] }, { "id": "40815", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P04055-1", "P51433-1", "Q9QZT3-1", "P14423-1", "Q9UL19-1", "Q9NWW9-1", "P53816-1", "Q86XP0-1", "P0C869-1", "Q9BZM2-1", "Q68DD2-1", "Q9NZ20-1", "Q9UNK4-1", "P14555-1", "P04054-1", "O15496-1", "P39877-1", "Q9NZK7-1", "Q8R3U1-1", "Q50L43-1", "Q9QZT4-1", "P31482-1", "Q9WVF6-1", "Q9Z0Y2-1", "P97391-1", "Q50L41-1", "Q9QUL3-1", "Q9QXX3-1", "Q8BZT7-1" ], "evidence": [ { "id": "40815", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40815" } ] }, { "id": "R-HSA-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "equation": "", "summary": "At the outer mitochondrial (OM) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-1524103" ], "enzyme_list": [ "Q9BZM2-1", "P0C869-1", "Q86XP0-1" ], "evidence": [ { "id": "R-HSA-1482604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482604" } ] }, { "id": "R-HSA-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P4A8-1", "P0C869-1", "Q86XP0-1", "Q3MJ16-3", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482612", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482612" } ] }, { "id": "R-HSA-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-426755" ], "output_participant_list": [ "R-ALL-1500604" ], "enzyme_list": [ "Q9BZM2-1", "P0C869-1", "Q86XP0-1" ], "evidence": [ { "id": "R-HSA-1482656", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482656" } ] }, { "id": "R-HSA-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P4A8-1", "P0C869-1", "Q86XP0-1", "Q3MJ16-3", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482685", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482685" } ] }, { "id": "R-HSA-1482745", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)", "equation": "", "summary": "At the inner mitochondrial membrane (IM), phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) to form 1-acyl lysophosphatidylglycerol (LPG) (Ghomashchi et al. 2010, Singer et al. 2002).", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-1524085" ], "enzyme_list": [ "P0C869-1", "Q86XP0-1", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482745" } ] }, { "id": "R-HSA-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A,B,D/E/F) (Ghomashchi et al. 2010), or by group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008). This produces 1-acyl lysophosphatidylserine (LPS).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53816-1", "P0C869-1", "Q86XP0-1", "Q3MJ16-3", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482771", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482771" } ] }, { "id": "R-HSA-1482847", "name": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)", "equation": "", "summary": "At the inner mitochondrial (IR) membrane, phosphatidylglycerol (PG) is hydrolysed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) (Ghomashchi et al. 2010) to form 2-acyl lysophosphatidylglycerol (LPG). Phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C869-1", "Q86XP0-1", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482847", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482847" } ] }, { "id": "R-HSA-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53816-1", "Q6P4A8-1", "O60733-1", "P0C869-1", "Q86XP0-1", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482856", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482856" } ] }, { "id": "R-HSA-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolysed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylcholine (LPC). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C869-1", "Q86XP0-1", "Q3MJ16-3", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482862", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482862" } ] }, { "id": "R-HSA-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 to form 1-acyl lysophosphatidylethanolamine (LPE). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G(4A/B/D/E/F) (Ghosh et al. 2006, Yamashita et al. 2009, Yamashita et al. 1999, Ghomashchi et al. 2010), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53816-1", "Q6P4A8-1", "O60733-1", "P0C869-1", "Q86XP0-1", "Q3MJ16-3", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482884", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482884" } ] }, { "id": "R-HSA-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010) to form 1-acyl lysophosphatidylglycerol (LPG).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BZM2-1", "P0C869-1", "Q86XP0-1" ], "evidence": [ { "id": "R-HSA-1482900", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482900" } ] }, { "id": "R-HSA-1791071", "name": "Expression of PLA2G4B", "equation": "", "summary": "The PLA2GB4B gene is transcribed to yield mRNA and the mRNA is translated to yield protein.", "cellular_location": "cytosol, nucleoplasm", "input_participant_list": [ "R-HSA-5642267" ], "output_participant_list": [ "R-HSA-535541" ], "enzyme_list": [ "P0C869-1" ], "evidence": [ { "id": "R-HSA-1791071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1791071" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1500604", "participant_name": "1-acyl LPA [cytosol]", "crossref": [ { "id": "C00681", "database": "COMPOUND", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "C00681", "database": "COMPOUND", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "C00681", "database": "COMPOUND", "url": "" }, { "id": "C00681", "database": "COMPOUND", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "C00681", "database": "COMPOUND", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "C00681", "database": "COMPOUND", "url": "" }, { "id": "16975", "database": "ChEBI", "url": "" }, { "id": "C00681", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1524085", "participant_name": "LCFA(-) [mitochondrial inner membrane]", "crossref": [ { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1524103", "participant_name": "LCFA(-) [mitochondrial outer membrane]", "crossref": [ { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" }, { "id": "C00060", "database": "COMPOUND", "url": "" }, { "id": "57560", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-426755", "participant_name": "PA [endoplasmic reticulum membrane]", "crossref": [ { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "57739", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-HSA-535541", "participant_name": "PLA2G4B [cytosol]", "crossref": [ { "id": "P0C869", "database": "ZINC target", "url": "" }, { "id": "3.1.1.4", "database": "IntEnz", "url": "" }, { "id": "P0C869", "database": "UniProt", "url": "" }, { "id": "NP_001185517.1", "database": "RefSeq", "url": "" }, { "id": "ENSP00000396045", "database": "Ensembl", "url": "" }, { "id": "PA24B_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "ENST00000458483", "database": "Ensembl", "url": "" }, { "id": "PA24B_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "ENSP00000416610", "database": "Ensembl", "url": "" }, { "id": "P0C869", "database": "PRO", "url": "" }, { "id": "P0C869", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000243708-PLA2G4B", "database": "HPA", "url": "" }, { "id": "HMDBP09120", "database": "HMDB Protein", "url": "" }, { "id": "ENST00000452633", "database": "Ensembl", "url": "" }, { "id": "P0C869", "database": "GeneCards", "url": "" }, { "id": "ENSG00000243708", "database": "Ensembl", "url": "" }, { "id": "NP_005081.1", "database": "RefSeq", "url": "" }, { "id": "1425", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "NP_001108105.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000243708", "database": "OpenTargets", "url": "" } ] }, { "participant_id": "R-HSA-5642267", "participant_name": "PLA2G4B gene [nucleoplasm]", "crossref": [ { "id": "ENSG00000243708", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0JNU3", "gene_name": "Aspg", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] } ] }, { "uniprot_ac": "A2AJ88", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] } ] }, { "uniprot_ac": "D2KX21", "gene_name": "Plaat1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] } ] }, { "uniprot_ac": "D3Z9B7", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] } ] }, { "uniprot_ac": "D3ZLB5", "gene_name": "Pla2g2f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLB5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLB5" } ] } ] }, { "uniprot_ac": "D3ZQH6", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] } ] }, { "uniprot_ac": "D3ZRC4", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] } ] }, { "uniprot_ac": "D4A1I6", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] } ] }, { "uniprot_ac": "D4A328", "gene_name": "LOC120099997", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] } ] }, { "uniprot_ac": "F1LPY6", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] } ] }, { "uniprot_ac": "F7F420", "gene_name": "Pla2g2d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F7F420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F420" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F7F420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F420" } ] } ] }, { "uniprot_ac": "O08709", "gene_name": "Prdx6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] } ] }, { "uniprot_ac": "O15496", "gene_name": "PLA2G10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O15496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15496" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O15496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15496" } ] } ] }, { "uniprot_ac": "O35244", "gene_name": "Prdx6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O75608", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] } ] }, { "uniprot_ac": "O88202", "gene_name": "Aspg", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] } ] }, { "uniprot_ac": "O95372", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] } ] }, { "uniprot_ac": "P04054", "gene_name": "PLA2G1B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] } ] }, { "uniprot_ac": "P04055", "gene_name": "Pla2g1b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] } ] }, { "uniprot_ac": "P04180", "gene_name": "LCAT", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] } ] }, { "uniprot_ac": "P07867", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] } ] }, { "uniprot_ac": "P07882", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] } ] }, { "uniprot_ac": "P0C548", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] } ] }, { "uniprot_ac": "P0C869", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] } ] }, { "uniprot_ac": "P0C871", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] } ] }, { "uniprot_ac": "P11150", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] } ] }, { "uniprot_ac": "P14423", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] } ] }, { "uniprot_ac": "P14555", "gene_name": "PLA2G2A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] } ] }, { "uniprot_ac": "P16301", "gene_name": "Lcat", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] } ] }, { "uniprot_ac": "P18424", "gene_name": "Lcat", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] } ] }, { "uniprot_ac": "P19835", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] } ] }, { "uniprot_ac": "P27656", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] } ] }, { "uniprot_ac": "P30041", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] } ] }, { "uniprot_ac": "P31482", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] } ] }, { "uniprot_ac": "P39105", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] } ] }, { "uniprot_ac": "P39877", "gene_name": "PLA2G5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] } ] }, { "uniprot_ac": "P39878", "gene_name": "Pla2g2c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P39878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39878" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P39878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39878" } ] } ] }, { "uniprot_ac": "P41247", "gene_name": "PNPLA4", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] } ] }, { "uniprot_ac": "P47712", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] } ] }, { "uniprot_ac": "P47713", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] } ] }, { "uniprot_ac": "P48076", "gene_name": "Pla2g2c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P48076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48076" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P48076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48076" } ] } ] }, { "uniprot_ac": "P50393", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] } ] }, { "uniprot_ac": "P51433", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] } ] }, { "uniprot_ac": "P53816", "gene_name": "PLAAT3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] } ] }, { "uniprot_ac": "P53817", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] } ] }, { "uniprot_ac": "P70470", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] } ] }, { "uniprot_ac": "P97391", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "P97823", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] } ] }, { "uniprot_ac": "Q03674", "gene_name": "PLB2", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] } ] }, { "uniprot_ac": "Q04958", "gene_name": "NTE1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q04958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04958" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q04958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04958" } ] } ] }, { "uniprot_ac": "Q08108", "gene_name": "PLB3", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q08108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08108" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q08108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08108" } ] } ] }, { "uniprot_ac": "Q08448", "gene_name": "LPL1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q08448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08448" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q08448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08448" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q08448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08448" } ] } ] }, { "uniprot_ac": "Q3MJ16", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q4KLN5", "gene_name": "Plaat5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] } ] }, { "uniprot_ac": "Q50L41", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] } ] }, { "uniprot_ac": "Q50L42", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] } ] }, { "uniprot_ac": "Q50L43", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] } ] }, { "uniprot_ac": "Q5BK26", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] } ] }, { "uniprot_ac": "Q5R387", "gene_name": "PLA2G2C", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q5R387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5R387" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q5R387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5R387" } ] } ] }, { "uniprot_ac": "Q64285", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] } ] }, { "uniprot_ac": "Q64GA5", "gene_name": "Pla2g4c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] } ] }, { "uniprot_ac": "Q675A5", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] } ] }, { "uniprot_ac": "Q68DD2", "gene_name": "PLA2G4F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] } ] }, { "uniprot_ac": "Q6P1J6", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q6P4A8", "gene_name": "PLBD1", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6P4A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P4A8" } ] } ] }, { "uniprot_ac": "Q6ZV29", "gene_name": "PNPLA7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] } ] }, { "uniprot_ac": "Q7KUD4", "gene_name": "iPLA2-VIA", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q7KUD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KUD4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q7KUD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KUD4" } ] } ] }, { "uniprot_ac": "Q7L5L3", "gene_name": "GDPD3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q7L5L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7L5L3" } ] } ] }, { "uniprot_ac": "Q86U10", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] } ] }, { "uniprot_ac": "Q86XP0", "gene_name": "PLA2G4D", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q86XP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XP0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q86XP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XP0" } ] } ] }, { "uniprot_ac": "Q8BG37", "gene_name": "Prdx6b", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "Q8BG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG37" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "Q8BG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG37" } ] } ] }, { "uniprot_ac": "Q8BJ56", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] } ] }, { "uniprot_ac": "Q8BZT7", "gene_name": "Pla2g3", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZT7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8BZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZT7" } ] } ] }, { "uniprot_ac": "Q8IML0", "gene_name": "Dmel\\CG14507", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8IML0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IML0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8IML0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IML0" } ] } ] }, { "uniprot_ac": "Q8IY17", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] } ] }, { "uniprot_ac": "Q8K1N1", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] } ] }, { "uniprot_ac": "Q8NCC3", "gene_name": "PLA2G15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] } ] }, { "uniprot_ac": "Q8R3U1", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] } ] }, { "uniprot_ac": "Q8VEB4", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] } ] }, { "uniprot_ac": "Q8WU67", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] } ] }, { "uniprot_ac": "Q91WW7", "gene_name": "Pnpla3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] } ] }, { "uniprot_ac": "Q91ZH7", "gene_name": "Abhd3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] } ] }, { "uniprot_ac": "Q96AD5", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] } ] }, { "uniprot_ac": "Q96KN8", "gene_name": "PLAAT5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] } ] }, { "uniprot_ac": "Q99LY2", "gene_name": "Gdpd3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q99LY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LY2" } ] } ] }, { "uniprot_ac": "Q9BZM1", "gene_name": "PLA2G12A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9BZM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9BZM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM1" } ] } ] }, { "uniprot_ac": "Q9BZM2", "gene_name": "PLA2G2F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9BZM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9BZM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM2" } ] } ] }, { "uniprot_ac": "Q9CPX5", "gene_name": "Plaat5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] } ] }, { "uniprot_ac": "Q9EPR2", "gene_name": "Pla2g12a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9EPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPR2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9EPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPR2" } ] } ] }, { "uniprot_ac": "Q9ESN3", "gene_name": "Pgap6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9ESN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9ESN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN3" } ] } ] }, { "uniprot_ac": "Q9HCN3", "gene_name": "PGAP6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCN3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9HCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCN3" } ] } ] }, { "uniprot_ac": "Q9HDD0", "gene_name": "PLAAT1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] } ] }, { "uniprot_ac": "Q9NP80", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] } ] }, { "uniprot_ac": "Q9NST1", "gene_name": "PNPLA3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] } ] }, { "uniprot_ac": "Q9NWW9", "gene_name": "PLAAT2", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] } ] }, { "uniprot_ac": "Q9NZ20", "gene_name": "PLA2G3", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ20" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ20" } ] } ] }, { "uniprot_ac": "Q9NZK7", "gene_name": "PLA2G2E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZK7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZK7" } ] } ] }, { "uniprot_ac": "Q9QUL3", "gene_name": "Pla2g2e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QUL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUL3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QUL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUL3" } ] } ] }, { "uniprot_ac": "Q9QXX3", "gene_name": "Pla2g10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QXX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXX3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QXX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXX3" } ] } ] }, { "uniprot_ac": "Q9QYL8", "gene_name": "Lypla2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] } ] }, { "uniprot_ac": "Q9QZT3", "gene_name": "Pla2g10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT3" } ] } ] }, { "uniprot_ac": "Q9QZT4", "gene_name": "Pla2g2f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT4" } ] } ] }, { "uniprot_ac": "Q9QZU4", "gene_name": "Plaat1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] } ] }, { "uniprot_ac": "Q9U969", "gene_name": "sws", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9U969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9U969" } ] } ] }, { "uniprot_ac": "Q9UL19", "gene_name": "PLAAT4", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] } ] }, { "uniprot_ac": "Q9UNK4", "gene_name": "PLA2G2D", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UNK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNK4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UNK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNK4" } ] } ] }, { "uniprot_ac": "Q9UP65", "gene_name": "PLA2G4C", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] } ] }, { "uniprot_ac": "Q9VMM8", "gene_name": "Dmel\\CG11029", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] } ] }, { "uniprot_ac": 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