{
    "uniprot_canonical_ac": "P0C7X1-1",
    "uniprot_ac": "P0C7X1",
    "uniprot_id": "TBC3H_HUMAN",
    "mass": {
        "chemical_mass": 62219.0,
        "monoisotopic_mass": 62219.0
    },
    "refseq": {
        "ac": "NP_001116864",
        "name": "TBC1 domain family member 3H",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116864"
    },
    "gene_names": [
        {
            "name": "TBC1D3H",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P0C7X1",
            "id": "P0C7X1"
        },
        {
            "name": "TBC1D3H",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116864",
            "id": "NP_001116864"
        }
    ],
    "protein_names": [
        {
            "name": "TBC1 domain family member 3H",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P0C7X1"
        },
        {
            "name": "TBC1 domain family member 3-like",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116864",
            "id": "NP_001116864"
        },
        {
            "name": "TBC1 domain family member 3H",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116864",
            "id": "NP_001116864"
        }
    ],
    "function": [
        {
            "annotation": "Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P0C7X1",
                    "url": "https://www.uniprot.org/uniprot/P0C7X1#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "P0C7X1",
                    "url": "https://www.uniprot.org/uniprot/P0C7X1"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "TBC1D3H",
            "url": "https://www.uniprot.org/uniprot/P0C7X1",
            "locus": {
                "chromosome": "HSCHR17_7_CTG4",
                "start_pos": 612435,
                "end_pos": 623327,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000277974",
                        "url": "https://www.ensembl.org/id/ENSG00000277974"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000274226",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000274226",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "TBC1D3H",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TBC1D3H",
            "database": "GeneCards",
            "categories": [
                "Gene Annotation",
                "Organism-specific"
            ]
        },
        {
            "id": "729877",
            "url": "https://www.ncbi.nlm.nih.gov/gene/729877",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "30708",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30708",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P0C7X1",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P0C7X1*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000195",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035969",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "hsa:729877",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:729877",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "610811",
            "url": "http://www.omim.org/entry/610811",
            "database": "MIM",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "NX_P0C7X1",
            "url": "https://www.nextprot.org/entry/NX_P0C7X1",
            "database": "neXtProt",
            "categories": [
                "Protein",
                "Organism-specific"
            ]
        },
        {
            "id": "4687814at2759",
            "url": "http://www.orthodb.org/?query=4687814at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47219",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47219:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00566",
            "url": "http://pfam.xfam.org/family/PF00566",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "P0C7X1",
            "url": "https://pharos.nih.gov/targets/P0C7X1",
            "database": "PHAROS",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "PR_P0C7X1",
            "url": "http://purl.obolibrary.org/obo/PR_P0C7X1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001116864",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116864",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P0C7X1",
            "url": "https://www.uniprot.org/uniprot/P0C7X1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P0C7X1-1",
            "url": "https://www.uniprot.org/uniprot/P0C7X1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF",
        "length": 549,
        "header": "sp|P0C7X1-1|TBC3H_HUMAN Isoform 1 of TBC1 domain family member 3H  OS=Homo sapiens OX=9606 GN=TBC1D3H PE=2 SV=3 CANONICAL=P0C7X1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P0C7X1-1",
            "url": "",
            "sequence": {
                "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF",
                "length": 549,
                "header": "sp|P0C7X1-1|TBC3H_HUMAN Isoform 1 of TBC1 domain family member 3H  OS=Homo sapiens OX=9606 GN=TBC1D3H PE=2 SV=3 CANONICAL=P0C7X1-1"
            },
            "locus": {
                "chromosome": "HSCHR17_7_CTG4",
                "start_pos": 621799,
                "end_pos": 612753,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000619743.4",
                        "url": "https://www.ensembl.org/id/ENST00000619743.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000481632.1",
                        "url": "https://www.ensembl.org/id/ENSP00000481632.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.",
            "journal": "Genomics",
            "date": "2006",
            "authors": "Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P0C7X1",
                    "url": "https://www.uniprot.org/uniprot/P0C7X1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16863688",
                    "url": "https://glygen.org/publication/PubMed/16863688"
                }
            ]
        },
        {
            "title": "Diversity of human copy number variation and multicopy genes.",
            "journal": "Science",
            "date": "2010",
            "authors": "Sudmant Peter H, Kitzman Jacob O, Antonacci Francesca, Alkan Can, Malig Maika, Tsalenko Anya, Sampas Nick, Bruhn Laurakay, Shendure Jay,  , Eichler Evan E",
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "P0C7X1",
                    "url": "https://www.uniprot.org/uniprot/P0C7X1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21030649",
                    "url": "https://glygen.org/publication/PubMed/21030649"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "hsa:729877",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:729877",
            "resource": "KEGG Pathway"
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    ],
    "orthologs": [],
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            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "GTPase activator activity",
                        "id": "GO:0005096",
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                        "pmid": ""
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            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
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    "pro_annotation": [],
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    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
    "sequence_features": {
        "n_linked_sites": [],
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        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": []
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