{
    "uniprot_canonical_ac": "P0C7P1-1",
    "uniprot_ac": "P0C7P1",
    "uniprot_id": "RBY1D_HUMAN",
    "mass": {
        "chemical_mass": 55775.0,
        "monoisotopic_mass": 55775.0
    },
    "refseq": {
        "ac": "NP_001006120",
        "name": "RNA-binding motif protein, Y chromosome, family 1 member D isoform 1",
        "summary": "This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120"
    },
    "gene_names": [
        {
            "name": "RBMY1D",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P0C7P1",
            "id": "P0C7P1"
        },
        {
            "name": "RBMY1D",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120",
            "id": "NP_001006120"
        },
        {
            "name": "hRBMY; RBM1; RBM2; RBMY1A1; YRRM1; YRRM2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120",
            "id": "NP_001006120"
        }
    ],
    "protein_names": [
        {
            "name": "RNA-binding motif protein, Y chromosome, family 1 member D",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P0C7P1"
        },
        {
            "name": "RNA-binding motif protein, Y chromosome, family 1 member D isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120",
            "id": "NP_001006120"
        },
        {
            "name": "RNA-binding motif protein, Y chromosome, family 1 member D; RNA-binding motif protein, Y chromosome, family 1 member A1; RNA-binding motif protein 1; RNA-binding motif protein 2; Y chromosome RNA recognition motif 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120",
            "id": "NP_001006120"
        }
    ],
    "function": [
        {
            "annotation": "RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P0C7P1",
                    "url": "https://www.uniprot.org/uniprot/P0C7P1#function"
                }
            ]
        },
        {
            "annotation": "This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001006120",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [
        {
            "tissue": {
                "name": "Adult mammalian kidney",
                "namespace": "UBERON",
                "id": "0000082",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000082"
            },
            "score": "27.56",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Stomach",
                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "score": "16.41",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Esophagus",
                "namespace": "UBERON",
                "id": "0001043",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043"
            },
            "score": "17.43",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Rectum",
                "namespace": "UBERON",
                "id": "0001052",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001052"
            },
            "score": "16.94",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Urinary bladder",
                "namespace": "UBERON",
                "id": "0001255",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255"
            },
            "score": "28.79",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "score": "16.49",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Liver",
                "namespace": "UBERON",
                "id": "0002107",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107"
            },
            "score": "16.88",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Prostate gland",
                "namespace": "UBERON",
                "id": "0002367",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367"
            },
            "score": "17.93",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        },
        {
            "tissue": {
                "name": "Thoracic mammary gland",
                "namespace": "UBERON",
                "id": "0005200",
                "url": "http://purl.obolibrary.org/obo/UBERON_0005200"
            },
            "score": "14.63",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000244395",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395"
                }
            ]
        }
    ],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P0C7P1",
                    "url": "https://www.uniprot.org/uniprot/P0C7P1"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "RBMY1D",
            "url": "https://www.uniprot.org/uniprot/P0C7P1",
            "locus": {
                "chromosome": "Y",
                "start_pos": 21880076,
                "end_pos": 21894526,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000244395",
                        "url": "https://www.ensembl.org/id/ENSG00000244395"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000244395",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244395",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd12382",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12382",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "RBMY1D",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RBMY1D",
            "database": "GeneCards",
            "categories": [
                "Gene Annotation",
                "Organism-specific"
            ]
        },
        {
            "id": "378949",
            "url": "https://www.ncbi.nlm.nih.gov/gene/378949",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "23915",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=23915",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "IPR000504",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR012604",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012604",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR012677",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035979",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "hsa:378949",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:378949",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "NX_P0C7P1",
            "url": "https://www.nextprot.org/entry/NX_P0C7P1",
            "database": "neXtProt",
            "categories": [
                "Protein",
                "Organism-specific"
            ]
        },
        {
            "id": "4701164at2759",
            "url": "http://www.orthodb.org/?query=4701164at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48034",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48034",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48034:SF17",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48034:SF17",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00076",
            "url": "http://pfam.xfam.org/family/PF00076",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08081",
            "url": "http://pfam.xfam.org/family/PF08081",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "P0C7P1",
            "url": "https://pharos.nih.gov/targets/P0C7P1",
            "database": "PHAROS",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "PR_P0C7P1",
            "url": "http://purl.obolibrary.org/obo/PR_P0C7P1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001006120",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P0C7P1",
            "url": "https://www.uniprot.org/uniprot/P0C7P1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P0C7P1-1",
            "url": "https://www.uniprot.org/uniprot/P0C7P1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P0C7P1-2",
            "url": "https://www.uniprot.org/uniprot/P0C7P1-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY",
        "length": 496,
        "header": "sp|P0C7P1-1|RBY1D_HUMAN Isoform 1 of RNA-binding motif protein, Y chromosome, family 1 member D  OS=Homo sapiens OX=9606 GN=RBMY1D PE=2 SV=1 CANONICAL=P0C7P1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P0C7P1-1",
            "url": "",
            "sequence": {
                "sequence": "MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY",
                "length": 496,
                "header": "sp|P0C7P1-1|RBY1D_HUMAN Isoform 1 of RNA-binding motif protein, Y chromosome, family 1 member D  OS=Homo sapiens OX=9606 GN=RBMY1D PE=2 SV=1 CANONICAL=P0C7P1-1"
            },
            "locus": {
                "chromosome": "Y",
                "start_pos": 21892513,
                "end_pos": 21880357,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000382680.5",
                        "url": "https://www.ensembl.org/id/ENST00000382680.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000372127.1",
                        "url": "https://www.ensembl.org/id/ENSP00000372127.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P0C7P1-2",
            "url": "",
            "sequence": {
                "sequence": "MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY",
                "length": 459,
                "header": "sp|P0C7P1-2|RBY1D_HUMAN Isoform 2 of RNA-binding motif protein, Y chromosome, family 1 member D  OS=Homo sapiens OX=9606 GN=RBMY1D PE=2 SV=1 CANONICAL=P0C7P1-1"
            },
            "locus": {
                "chromosome": "Y",
                "start_pos": 21892513,
                "end_pos": 21880357,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000418956.2",
                        "url": "https://www.ensembl.org/id/ENST00000418956.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000399181.2",
                        "url": "https://www.ensembl.org/id/ENSP00000399181.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "hsa:378949",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:378949",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "positive regulation of mRNA splicing, via spliceosome",
                        "id": "GO:0048026",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048026",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA processing",
                        "id": "GO:0006397",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA splicing",
                        "id": "GO:0008380",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "RNA binding",
                        "id": "GO:0003723",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleolus",
                        "id": "GO:0005730",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spliceosomal complex",
                        "id": "GO:0005681",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P0C7P1",
                                "url": "https://www.uniprot.org/uniprot/P0C7P1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 102,
            "end_pos": 104,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 102,
                "end_pos": 104
            }
        ]
    },
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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