{ "uniprot_canonical_ac": "P09681-1", "uniprot_ac": "P09681", "uniprot_id": "GIP_HUMAN", "mass": { "chemical_mass": 17108.0, "monoisotopic_mass": 17108.0 }, "refseq": { "ac": "NP_004114", "name": "gastric inhibitory polypeptide preproprotein", "summary": "This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" }, "gene_names": [ { "name": "GIP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09681", "id": "P09681" }, { "name": "GIP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114", "id": "NP_004114" } ], "protein_names": [ { "name": "Gastric inhibitory polypeptide", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09681" }, { "name": "GIP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09681" }, { "name": "Glucose-dependent insulinotropic polypeptide", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09681" }, { "name": "Incretin hormone", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09681" }, { "name": "gastric inhibitory polypeptide preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114", "id": "NP_004114" }, { "name": "glucose-dependent insulinotropic polypeptide; incretin hormone", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114", "id": "NP_004114" } ], "function": [ { "annotation": "GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes.", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" }, { "database": "PubMed", "id": "36111559", "url": "https://glygen.org/publication/PubMed/36111559" } ] }, { "annotation": "Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" }, { "database": "PubMed", "id": "36539382", "url": "https://glygen.org/publication/PubMed/36539382" } ] }, { "annotation": "Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies.", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" }, { "database": "PubMed", "id": "36799940", "url": "https://glygen.org/publication/PubMed/36799940" } ] }, { "annotation": "Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" }, { "database": "PubMed", "id": "35397169", "url": "https://glygen.org/publication/PubMed/35397169" } ] }, { "annotation": "Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.", "evidence": [ { "database": "UniProtKB", "id": "P09681", "url": "https://www.uniprot.org/uniprot/P09681#function" } ] }, { "annotation": "The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" }, { "database": "PubMed", "id": "35846282", "url": "https://glygen.org/publication/PubMed/35846282" } ] }, { "annotation": "This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P09681", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P09681" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 81, "end_pos": 81, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "17", "chr_pos": "48964324", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "K81", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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functional glucose-dependent insulinotropic peptide receptors.", "journal": "Endocrinology", "date": "2000", "authors": "Bollag RJ, Zhong Q, Phillips P, Min L, Zhong L, Cameron R, Mulloy AL, Rasmussen H, Qin F, Ding KH, Isales CM", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "10698200", "url": "https://glygen.org/publication/PubMed/10698200" } ] }, { "title": "Src tyrosine kinase is a novel direct effector of G proteins.", "journal": "Cell", "date": "2000", "authors": "Ma YC, Huang J, Ali S, Lowry W, Huang XY", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "11007482", "url": "https://glygen.org/publication/PubMed/11007482" } ] }, { "title": "Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.", "journal": "Cytogenetics and cell genetics", "date": "2000", "authors": "Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "11060443", "url": "https://glygen.org/publication/PubMed/11060443" } ] }, { "title": "The amino acid sequence of human glucagon.", "journal": "FEBS letters", "date": "1972", "authors": "Thomsen J, Kristiansen K, Brunfeldt K, Sundby F", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "11946536", "url": "https://glygen.org/publication/PubMed/11946536" } ] }, { "title": "Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman HA, Koch WJ, Luttrell LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12036966", "url": "https://glygen.org/publication/PubMed/12036966" } ] }, { "title": "Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Dessauer CW, Chen-Goodspeed M, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12058044", "url": "https://glygen.org/publication/PubMed/12058044" } ] }, { "title": 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pharmacology", "date": "2003", "authors": "Zhang JY, Nawoschik S, Kowal D, Smith D, Spangler T, Ochalski R, Schechter L, Dunlop J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "12860470", "url": "https://glygen.org/publication/PubMed/12860470" } ] }, { "title": "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "1992", "authors": "Mayo KE", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "1333056", "url": "https://glygen.org/publication/PubMed/1333056" } ] }, { "title": "Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles.", "journal": "The Journal of biological chemistry", "date": "1958", "authors": "SUTHERLAND EW, RALL TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "13549488", "url": "https://glygen.org/publication/PubMed/13549488" } ] }, { "title": "Insights into G protein structure, function, and regulation.", "journal": "Endocrine reviews", "date": "2003", "authors": "Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "14671004", "url": "https://glygen.org/publication/PubMed/14671004" } ] }, { "title": "Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "1517224", "url": "https://glygen.org/publication/PubMed/1517224" } ] }, { "title": "Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists.", "journal": "European journal of pharmacology", "date": "2004", "authors": "Dallas-Yang Q, Shen X, Strowski M, Brady E, Saperstein R, Gibson RE, Szalkowski D, Qureshi SA, Candelore MR, Fenyk-Melody JE, Parmee ER, Zhang BB, Jiang G", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "15464082", "url": "https://glygen.org/publication/PubMed/15464082" } ] }, { "title": "The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2005", "authors": "Koehler JA, Yusta B, Drucker DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "15471943", "url": "https://glygen.org/publication/PubMed/15471943" } ] }, { "title": "NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2004", "authors": "Ala\u00f1a I\u00f1igo, Hewage Chandralal M, Malthouse J Paul G, Parker Jeremy C, Gault Victor A, O'Harte Finbarr P M", "evidence": [ { "database": "UniProtKB", "id": "P09681", "url": "https://www.uniprot.org/uniprot/P09681" } ], "reference": [ { "type": "PubMed", "id": "15522230", "url": "https://glygen.org/publication/PubMed/15522230" } ] }, { "title": "Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders.", "journal": "Clinical science (London, England : 1979)", "date": "2005", "authors": "Gorrell MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-400511", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400511" } ], "reference": [ { "type": "PubMed", "id": "15584901", "url": "https://glygen.org/publication/PubMed/15584901" } ] }, { "title": "Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients.", "journal": "Lung", "date": "2004", "authors": "Beeh KM, Beier J, Lerch C, Schulz AK, Buhl R", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "15765929", "url": "https://glygen.org/publication/PubMed/15765929" } ] }, { "title": "Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system.", "journal": "Frontiers in bioscience : a journal and virtual library", "date": "2005", "authors": "Maurice DH", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "15769620", "url": "https://glygen.org/publication/PubMed/15769620" } ] }, { "title": "The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.", "journal": "International journal of biological sciences", "date": "2005", "authors": "Siderovski DP, Willard FS", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "15951850", "url": "https://glygen.org/publication/PubMed/15951850" } ] }, { "title": "Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2006", "authors": "Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K, Egan JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-400511", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400511" } ], "reference": [ { "type": "PubMed", "id": "16219666", "url": "https://glygen.org/publication/PubMed/16219666" } ] }, { "title": "Preferential inhibition of human phosphodiesterase 4 by ibudilast.", "journal": "Life sciences", "date": "2006", "authors": "Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, Natsumeda Y, Noguchi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16313925", "url": "https://glygen.org/publication/PubMed/16313925" } ] }, { "title": "G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Violin JD, Ren XR, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16687412", "url": "https://glygen.org/publication/PubMed/16687412" } ] }, { "title": "Structural basis of function in heterotrimeric G proteins.", "journal": "Quarterly reviews of biophysics", "date": "2006", "authors": "Oldham WM, Hamm HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "16923326", "url": "https://glygen.org/publication/PubMed/16923326" } ] }, { "title": "Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.", "journal": "Current medicinal chemistry", "date": "2006", "authors": "Huang Z, Mancini JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "17168849", "url": "https://glygen.org/publication/PubMed/17168849" } ] }, { "title": "Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide.", "journal": "DNA and cell biology", "date": "1992", "authors": "Ohkubo S, Kimura C, Ogi K, Okazaki K, Hosoya M, Onda H, Miyata A, Arimura A, Fujino M", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "1739432", "url": "https://glygen.org/publication/PubMed/1739432" } ] }, { "title": "PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast.", "journal": "International journal of chronic obstructive pulmonary disease", "date": "2007", "authors": "Boswell-Smith V, Spina D", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "18044684", "url": "https://glygen.org/publication/PubMed/18044684" } ] }, { "title": "A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.", "journal": "Endocrinology", "date": "2008", "authors": "Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A, Pedraza M, Mondala H, Gao H, Bagnol D, Chen R, Jones RM, Behan DP, Leonard J", "evidence": [ { "database": "Reactome", "id": "R-HSA-400511", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400511" } ], "reference": [ { "type": "PubMed", "id": "18202141", "url": "https://glygen.org/publication/PubMed/18202141" } ] }, { "title": "Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.", "journal": "Diabetes", "date": "2008", "authors": "Edfalk S, Steneberg P, Edlund H", "evidence": [ { "database": "Reactome", "id": "R-HSA-400511", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400511" } ], "reference": [ { "type": "PubMed", "id": "18519800", "url": "https://glygen.org/publication/PubMed/18519800" } ] }, { "title": "Dissociation of heterotrimeric g proteins in cells.", "journal": "Science signaling", "date": "2008", "authors": "Lambert NA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "18577758", "url": "https://glygen.org/publication/PubMed/18577758" } ] }, { "title": "Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2008", "authors": "Fujita Y, Chui JW, King DS, Zhang T, Seufert J, Pownall S, Cheung AT, Kieffer TJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-400511", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400511" } ], "reference": [ { "type": "PubMed", "id": "18593849", "url": "https://glygen.org/publication/PubMed/18593849" } ] }, { "title": "The efficacy and safety of cilomilast in COPD.", "journal": "Drugs", "date": "2008", "authors": "Rennard S, Knobil K, Rabe KF, Morris A, Schachter N, Locantore N, Canonica WG, Zhu Y, Barnhart F", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19105585", "url": "https://glygen.org/publication/PubMed/19105585" } ] }, { "title": "AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis.", "journal": "Current opinion in investigational drugs (London, England : 2000)", "date": "2009", "authors": "Nazarian R, Weinberg JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19876791", "url": "https://glygen.org/publication/PubMed/19876791" } ] }, { "title": "Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease.", "journal": "Expert opinion on pharmacotherapy", "date": "2009", "authors": "Rolan P, Hutchinson M, Johnson K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "19929708", "url": "https://glygen.org/publication/PubMed/19929708" } ] }, { "title": "The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.", "journal": "Pulmonary pharmacology & therapeutics", "date": "2010", "authors": "Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "20381629", "url": "https://glygen.org/publication/PubMed/20381629" } ] }, { "title": "Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery.", "journal": "European journal of pharmacology", "date": "2011", "authors": "Yamazaki T, Anraku T, Matsuzawa S", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "21036126", "url": "https://glygen.org/publication/PubMed/21036126" } ] }, { "title": "beta-Arrestin: a protein that regulates beta-adrenergic receptor function.", "journal": "Science (New York, N.Y.)", "date": "1990", "authors": "Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2163110", "url": "https://glygen.org/publication/PubMed/2163110" } ] }, { "title": "Pharmacology of the bipyridines: amrinone and milrinone.", "journal": "Circulation", "date": "1986", "authors": "Alousi AA, Johnson DC", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2417744", "url": "https://glygen.org/publication/PubMed/2417744" } ] }, { "title": "Advances in targeting cyclic nucleotide phosphodiesterases.", "journal": "Nature reviews. Drug discovery", "date": "2014", "authors": "Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "24687066", "url": "https://glygen.org/publication/PubMed/24687066" } ] }, { "title": "Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Graziano MP, Freissmuth M, Gilman AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2491850", "url": "https://glygen.org/publication/PubMed/2491850" } ] }, { "title": "Pharmacology of positive inotropic phosphodiesterase III inhibitors.", "journal": "European heart journal", "date": "1989", "authors": "Honerjager P", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2553411", "url": "https://glygen.org/publication/PubMed/2553411" } ] }, { "title": "Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Mitsuhashi M, Mitsuhashi T, Payan DG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2553705", "url": "https://glygen.org/publication/PubMed/2553705" } ] }, { "title": "Pentoxifylline for intermittent claudication.", "journal": "The Cochrane database of systematic reviews", "date": "2015", "authors": "Salhiyyah K, Forster R, Senanayake E, Abdel-Hadi M, Booth A, Michaels JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "26417854", "url": "https://glygen.org/publication/PubMed/26417854" } ] }, { "title": "Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene.", "journal": "Mol. Endocrinol.", "date": "1989", "authors": "Inagaki N, Seino Y, Takeda J, Yano H, Yamada Y, Bell GI, Eddy RL, Fukushima Y, Byers MG, Shows TB, et al.", "evidence": [ { "database": "UniProtKB", "id": "P09681", "url": "https://www.uniprot.org/uniprot/P09681" } ], "reference": [ { "type": "PubMed", "id": "2739653", "url": "https://glygen.org/publication/PubMed/2739653" } ] }, { "title": "Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma.", "journal": "FEBS letters", "date": "1987", "authors": "Rall T, Harris BA", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "2826231", "url": "https://glygen.org/publication/PubMed/2826231" } ] }, { "title": "Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1986", "authors": "Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "2871555", "url": "https://glygen.org/publication/PubMed/2871555" } ] }, { "title": "Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Takeda J, Seino Y, Tanaka K, Fukumoto H, Kayano T, Takahashi H, Mitani T, Kurono M, Suzuki T, Tobe T, et al.", "evidence": [ { "database": "UniProtKB", "id": "P09681", "url": "https://www.uniprot.org/uniprot/P09681" }, { "database": "Reactome", "id": "R-HSA-400511", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-400511" } ], "reference": [ { "type": "PubMed", "id": "2890159", "url": "https://glygen.org/publication/PubMed/2890159" } ] }, { "title": "Effect and safety of roflumilast for chronic obstructive pulmonary disease in Chinese patients.", "journal": "Medicine", "date": "2018", "authors": "Liu DY, Wang ZG, Gao Y, Zhang HM, Zhang YX, Wang XJ, Peng D", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "29443750", "url": "https://glygen.org/publication/PubMed/29443750" } ] }, { "title": "Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge.", "journal": "Journal of nanobiotechnology", "date": "2018", "authors": "Liu FC, Yu HP, Lin CY, Elzoghby AO, Hwang TL, Fang JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "29602314", "url": "https://glygen.org/publication/PubMed/29602314" } ] }, { "title": "IL-12/IL-23p40 identified as a downstream target of apremilast in ex vivo models of arthritis.", "journal": "Therapeutic advances in musculoskeletal disease", "date": "2019", "authors": "Kragstrup TW, Adams M, Lomholt S, Nielsen MA, Heftdal LD, Schafer P, Deleuran B", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "30833991", "url": "https://glygen.org/publication/PubMed/30833991" } ] }, { "title": "Isolation and characterization of the human Gs alpha gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1988", "authors": "Kozasa T, Itoh H, Tsukamoto T, Kaziro Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "3127824", "url": "https://glygen.org/publication/PubMed/3127824" } ] }, { "title": "Crisaborole 2% ointment for the treatment of intertriginous, anogenital, and facial psoriasis: A double-blind, randomized, vehicle-controlled trial.", "journal": "Journal of the American Academy of Dermatology", "date": "2020", "authors": "Hashim PW, Chima M, Kim HJ, Bares J, Yao CJ, Singer G, Chen T, Genece J, Baum D, Kimmel GW, Nia JK, Gagliotti M, Lebwohl MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "31279028", "url": "https://glygen.org/publication/PubMed/31279028" } ] }, { "title": "Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD.", "journal": "Respiratory research", "date": "2019", "authors": "Singh D, Beeh KM, Colgan B, Kornmann O, Leaker B, Watz H, Lucci G, Geraci S, Emirova A, Govoni M, Nandeuil MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "31399091", "url": "https://glygen.org/publication/PubMed/31399091" } ] }, { "title": "Simple assessment of quality of life and lower limb functional capacity during cilostazol treatment - results of the SHort-tERm cIlostazol eFFicacy and quality of life (SHERIFF) study.", "journal": "VASA. Zeitschrift fur Gefasskrankheiten", "date": "2020", "authors": "Farkas K, Kolossvary E, Jarai Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "31983287", "url": "https://glygen.org/publication/PubMed/31983287" } ] }, { "title": "Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases.", "journal": "Frontiers in pharmacology", "date": "2020", "authors": "Phillips JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32226383", "url": "https://glygen.org/publication/PubMed/32226383" } ] }, { "title": "Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19.", "journal": "Metabolism: clinical and experimental", "date": "2020", "authors": "Dalamaga M, Karampela I, Mantzoros CS", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32497535", "url": "https://glygen.org/publication/PubMed/32497535" } ] }, { "title": "Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19.", "journal": "Medical hypotheses", "date": "2020", "authors": "Maldonado V, Loza-Mejia MA, Chavez-Alderete J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32540603", "url": "https://glygen.org/publication/PubMed/32540603" } ] }, { "title": "COVID-19 patients with psoriasis and psoriatic arthritis on biologic immunosuppressant therapy vs apremilast in North Spain.", "journal": "Dermatologic therapy", "date": "2020", "authors": "Queiro Silva R, Armesto S, Gonzalez Vela C, Naharro Fernandez C, Gonzalez-Gay MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32618402", "url": "https://glygen.org/publication/PubMed/32618402" } ] }, { "title": "Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients.", "journal": "Pharmacology research & perspectives", "date": "2020", "authors": "Hendry BM, Stafford N, Arnold AD, Sangwaiya A, Manglam V, Rosen SD, Arnold J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "32715661", "url": "https://glygen.org/publication/PubMed/32715661" } ] }, { "title": "Pentoxifylline: A Drug with Antiviral and Anti-Inflammatory Effects to Be Considered in the Treatment of Coronavirus Disease 2019.", "journal": "Medical principles and practice : international journal of the Kuwait University, Health Science Centre", "date": "2021", "authors": "Ghasemnejad-Berenji M, Pashapour S, Sadeghpour S", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "33049737", "url": "https://glygen.org/publication/PubMed/33049737" } ] }, { "title": "Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2022", "authors": "Grespan E, Guolo A, Muscelli E, Ferrannini E, Mari A", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" } ], "reference": [ { "type": "PubMed", "id": "35397169", "url": "https://glygen.org/publication/PubMed/35397169" } ] }, { "title": "The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection.", "journal": "Frontiers in endocrinology", "date": "2022", "authors": "Lindquist P, Gasbjerg LS, Mokrosinski J, Holst JJ, Hauser AS, Rosenkilde MM", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" } ], "reference": [ { "type": "PubMed", "id": "35846282", "url": "https://glygen.org/publication/PubMed/35846282" } ] }, { "title": "GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2022-11-25", "authors": "Heimb\u00fcrger Sebastian M\u00f8ller Nguyen, Hoe Bj\u00f8rn, Nielsen Chris Neumann, Bergman Natasha Chidekel, Skov-Jeppesen Kirsa, Hartmann Bolette, Holst Jens Juul, Dela Flemming, Overgaard Julie, St\u00f8rling Joachim, Vilsb\u00f8ll Tina, Dejgaard Thomas Fremming, Havelund Jesper Foged, Gorshkov Vladimir, Kjeldsen Frank, F\u00e6rgeman Nils Joakim, Madsen Martin R\u00f8nn, Christensen Mikkel B, Knop Filip Krag", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" } ], "reference": [ { "type": "PubMed", "id": "36111559", "url": "https://glygen.org/publication/PubMed/36111559" } ] }, { "title": "Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation.", "journal": "Journal of diabetes investigation", "date": "2022-12-20", "authors": "Alsalim Wathik, Lindgren Ola, Ahr\u00e9n Bo", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" } ], "reference": [ { "type": "PubMed", "id": "36539382", "url": "https://glygen.org/publication/PubMed/36539382" } ] }, { "title": "Human Epicardial Adipose Tissue Expresses Glucose-dependent Insulinotropic Polypeptide, Glucagon and Glucagon-Like Peptide 1 Receptors as Potential Targets of Pleiotropic Therapies.", "journal": "European journal of preventive cardiology", "date": "2023-02-17", "authors": "Malavazos Alexis Elias, Iacobellis Gianluca, Dozio Elena, Basilico Sara, Di Vincenzo Angelica, Dubini Carola, Menicanti Lorenzo, Vianello Elena, Meregalli Chiara, Ruocco Chiara, Ragni Maurizio, Secchi Francesco, Spagnolo Pietro, Castelvecchio Serenella, Morricone Lelio, Buscemi Silvio, Giordano Antonio, Goldberger Jeffrey J, Carruba Michele, Cinti Saverio, Corsi Romanelli Massimiliano Marco, Nisoli Enzo", "evidence": [ { "database": "RefSeq", "id": "NP_004114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004114" } ], "reference": [ { "type": "PubMed", "id": "36799940", "url": "https://glygen.org/publication/PubMed/36799940" } ] }, { "title": "Structure of the human vasoactive intestinal polypeptide gene.", "journal": "DNA (Mary Ann Liebert, Inc.)", "date": "1985", "authors": "Tsukada T, Horovitch SJ, Montminy MR, Mandel G, Goodman RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": 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"evidence": [ { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "6192430", "url": "https://glygen.org/publication/PubMed/6192430" } ] }, { "title": "The isolation and sequencing of human gastric inhibitory peptide (GIP).", "journal": "FEBS Lett.", "date": "1984", "authors": "Moody AJ, Thim L, Valverde I", "evidence": [ { "database": "UniProtKB", "id": "P09681", "url": "https://www.uniprot.org/uniprot/P09681" }, { "database": "Reactome", "id": "R-HSA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-420092" } ], "reference": [ { "type": "PubMed", "id": "6745415", "url": "https://glygen.org/publication/PubMed/6745415" } ] }, { "title": "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.", "journal": "FEBS letters", "date": "1995", "authors": "Volz A, Goke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, 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