{ "uniprot_canonical_ac": "P09630-1", "uniprot_ac": "P09630", "uniprot_id": "HXC6_HUMAN", "mass": { "chemical_mass": 26915.0, "monoisotopic_mass": 26915.0 }, "refseq": { "ac": "NP_004494", "name": "homeobox protein Hox-C6 isoform 1", "summary": "This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" }, "gene_names": [ { "name": "HOXC6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09630", "id": "P09630" }, { "name": "CP25; HHO.C8; HOX3; HOX3C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494", "id": "NP_004494" }, { "name": "HOX3C", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09630", "id": "P09630" }, { "name": "HOXC6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494", "id": "NP_004494" } ], "protein_names": [ { "name": "Homeobox protein Hox-C6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09630" }, { "name": "Homeobox protein CP25", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09630" }, { "name": "Homeobox protein HHO.C8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09630" }, { "name": "Homeobox protein Hox-3C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09630" }, { "name": "homeo box C8 protein; homeo box 3C; homeobox protein CP25; homeobox protein HHO.C8; homeobox protein Hox-3C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494", "id": "NP_004494" }, { "name": "homeobox protein Hox-C6 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494", "id": "NP_004494" } ], "function": [ { "annotation": "HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" }, { "database": "PubMed", "id": "35008435", "url": "https://glygen.org/publication/PubMed/35008435" } ] }, { "annotation": "HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma.", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" }, { "database": "PubMed", "id": "34763232", "url": "https://glygen.org/publication/PubMed/34763232" } ] }, { "annotation": "High expression of HOXC6 predicts a poor prognosis and induces proliferation and inflammation in multiple myeloma cells.", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" }, { "database": "PubMed", "id": "37202556", "url": "https://glygen.org/publication/PubMed/37202556" } ] }, { "annotation": "LINC01857 promotes the proliferation, migration, and invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6.", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" }, { "database": "PubMed", "id": "35468304", "url": "https://glygen.org/publication/PubMed/35468304" } ] }, { "annotation": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.", "evidence": [ { "database": "UniProtKB", "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630#function" } ] }, { "annotation": "The Effects of Differentially-Expressed Homeobox Family Genes on the Prognosis and HOXC6 on Immune Microenvironment Orchestration in Colorectal Cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" }, { "database": "PubMed", "id": "34950145", "url": "https://glygen.org/publication/PubMed/34950145" } ] }, { "annotation": "This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs755466327", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755466327" }, { "id": "rs755466327", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755466327" }, { "id": "rs755466327", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755466327" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 147, "end_pos": 147, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IYS->NYS).", "chr_id": "12", "chr_pos": "54029694", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I147", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1158009105", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1158009105" }, { "id": "rs1158009105", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1158009105" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 198, "end_pos": 198, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KES->NES).", "chr_id": "12", "chr_pos": "54029848", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K198", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs775380956", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs775380956" }, { "id": "rs775380956", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs775380956" }, { "id": "rs775380956", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs775380956" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 77, "end_pos": 77, "sequence_org": "F", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSF->NSS).", "chr_id": "12", "chr_pos": "54028751", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "F77", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1368012211", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1368012211" }, { "id": "rs1368012211", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1368012211#frequency_tab" }, { "id": "rs1368012211", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1368012211" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 8, "end_pos": 8, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NSS).", "chr_id": "12", "chr_pos": "54028543", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P8", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1368012211", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1368012211" }, { "id": "rs1368012211", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1368012211#frequency_tab" }, { "id": "rs1368012211", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1368012211" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 8, "end_pos": 8, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NTS).", "chr_id": "12", "chr_pos": "54028543", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P8", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P09630", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P09630" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 92, "end_pos": 92, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "L", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NTL->NTS).", "chr_id": "12", "chr_pos": "54028796", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "L92", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1440055649", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1440055649" }, { "id": "rs1440055649", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1440055649" }, { "id": "rs1440055649", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1440055649" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 99, "end_pos": 99, "sequence_org": "S", "sequence_mut": "*", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->*).", "chr_id": "12", "chr_pos": "54028817", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S99", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "89.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "41.27", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "51.84", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "87.17", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "77.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "37.33", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "57.28", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "59.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "61.05", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "55.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "36.19", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "60.91", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "85.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P09630", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09630" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630" } ], "common_name": "Human" } ], "gene": [ { "name": "HOXC6", "url": "https://www.uniprot.org/uniprot/P09630", "locus": { "chromosome": "12", "start_pos": 54030823, "end_pos": 53990624, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000197757", "url": "https://www.ensembl.org/id/ENSG00000197757" } ] } } ], "crossref": [ { "id": "ENSG00000197757", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000197757", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P09630", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P09630", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "HOXC6", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=HOXC6", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "3223", "url": "https://www.ncbi.nlm.nih.gov/gene/3223", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "5128", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5128", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P09630", "url": "https://www.ebi.ac.uk/intact/interactors/id:P09630*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:3223", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3223", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "142972", "url": "http://www.omim.org/entry/142972", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P09630", "url": "https://www.nextprot.org/entry/NX_P09630", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P09630", "url": "https://oglcnac.org/atlas/detail/P09630", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "CHLTGGQ", "url": "https://omabrowser.org/oma/group/CHLTGGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "728401at2759", "url": "http://www.orthodb.org/?query=728401at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45659", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45659", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45659:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45659:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "http://pfam.xfam.org/family/PF00046", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P09630", "url": "https://pharos.nih.gov/targets/P09630", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P09630", "url": "http://purl.obolibrary.org/obo/PR_P09630", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D6RBH4", "url": "https://www.uniprot.org/uniprot/D6RBH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RBH4-1", "url": "https://www.uniprot.org/uniprot/D6RBH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RC34", "url": "https://www.uniprot.org/uniprot/D6RC34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RC34-1", "url": "https://www.uniprot.org/uniprot/D6RC34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09630-1", "url": "https://www.uniprot.org/uniprot/P09630-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09630-2", "url": "https://www.uniprot.org/uniprot/P09630-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE", "length": 235, "header": "sp|P09630-1|HXC6_HUMAN Isoform 1 of Homeobox protein Hox-C6 OS=Homo sapiens OX=9606 GN=HOXC6 PE=2 SV=3 CANONICAL=P09630-1" }, "isoforms": [ { "isoform_ac": "D6RBH4-1", "url": "", "sequence": { "sequence": "MLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHS", "length": 51, "header": "tr|D6RBH4-1|HXC6_HUMAN Computationally mapped isoform of Homeobox protein Hox-C6 OS=Homo sapiens OX=9606 GN=HOXC6 PE=2 SV=8 CANONICAL=P09630-1" }, "locus": { "chromosome": "12", "start_pos": 54028920, "end_pos": 54028768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000504315.1", "url": "https://www.ensembl.org/id/ENST00000504315.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000424124.1", "url": "https://www.ensembl.org/id/ENSP00000424124.1" } ] } }, { "isoform_ac": "D6RC34-1", "url": "", "sequence": { "sequence": "MLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSVCFVPGSLGVGYGADRRRGR", "length": 71, "header": "tr|D6RC34-1|HXC6_HUMAN Computationally mapped isoform of Homeobox protein Hox-C6 OS=Homo sapiens OX=9606 GN=HOXC6 PE=2 SV=1 CANONICAL=P09630-1" }, "locus": { "chromosome": "12", "start_pos": 54029689, "end_pos": 54028768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000509328.1", "url": "https://www.ensembl.org/id/ENST00000509328.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000423898.1", "url": "https://www.ensembl.org/id/ENSP00000423898.1" } ] } }, { "isoform_ac": "P09630-1", "url": "", "sequence": { "sequence": "MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE", "length": 235, "header": "sp|P09630-1|HXC6_HUMAN Isoform 1 of Homeobox protein Hox-C6 OS=Homo sapiens OX=9606 GN=HOXC6 PE=2 SV=3 CANONICAL=P09630-1" }, "locus": { "chromosome": "12", "start_pos": 54029959, "end_pos": 54028522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000243108.5", "url": "https://www.ensembl.org/id/ENST00000243108.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000243108.4", "url": "https://www.ensembl.org/id/ENSP00000243108.4" } ] } }, { "isoform_ac": "P09630-2", "url": "", "sequence": { "sequence": "MLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE", "length": 153, "header": "sp|P09630-2|HXC6_HUMAN Isoform 2 of Homeobox protein Hox-C6 OS=Homo sapiens OX=9606 GN=HOXC6 PE=2 SV=3 CANONICAL=P09630-1" }, "locus": { "chromosome": "12", "start_pos": 54029959, "end_pos": 54028768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394331.3", "url": "https://www.ensembl.org/id/ENST00000394331.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000377864.3", "url": "https://www.ensembl.org/id/ENSP00000377864.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 99, "start_aa": "Ser", "end_pos": 99, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser99", "evidence": [ { "id": "P09630", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P09630" }, { "id": "30620550", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30620550" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Organization of human class I homeobox genes.", "journal": "Genome", "date": "1989", "authors": "Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A", "evidence": [ { "database": "UniProtKB", "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630" } ], "reference": [ { "type": "PubMed", "id": "2576652", "url": "https://glygen.org/publication/PubMed/2576652" } ] }, { "title": "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E, et al.", "evidence": [ { "database": "UniProtKB", "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630" } ], "reference": [ { "type": "PubMed", "id": "2885844", "url": "https://glygen.org/publication/PubMed/2885844" } ] }, { "title": "At least three human homeoboxes on chromosome 12 belong to the same transcription unit.", "journal": "Nucleic Acids Res.", "date": "1988", "authors": "Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E", "evidence": [ { "database": "UniProtKB", "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630" } ], "reference": [ { "type": "PubMed", "id": "2898768", "url": "https://glygen.org/publication/PubMed/2898768" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "P09630", "url": "https://oglcnac.org/atlas/detail/P09630" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "HOXC6 in the prognosis of prostate cancer.", "journal": "Artificial cells, nanomedicine, and biotechnology", "date": "2019", "authors": "Zhou J, Yang X, Song P, Wang H, Wang X", "evidence": [ { "database": "GlyGen", "id": "A0307", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "31271305", "url": "https://glygen.org/publication/PubMed/31271305" } ] }, { "title": "HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma.", "journal": "International immunopharmacology", "date": "2021", "authors": "Yu M, Yu S, Zhou W, Yi B, Liu Y", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" } ], "reference": [ { "type": "PubMed", "id": "34763232", "url": "https://glygen.org/publication/PubMed/34763232" } ] }, { "title": "The Effects of Differentially-Expressed Homeobox Family Genes on the Prognosis and HOXC6 on Immune Microenvironment Orchestration in Colorectal Cancer.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Qi L, Ye C, Zhang D, Bai R, Zheng S, Hu W, Yuan Y", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" } ], "reference": [ { "type": "PubMed", "id": "34950145", "url": "https://glygen.org/publication/PubMed/34950145" } ] }, { "title": "HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Jeong S, Kim SA, Ahn SG", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" } ], "reference": [ { "type": "PubMed", "id": "35008435", "url": "https://glygen.org/publication/PubMed/35008435" } ] }, { "title": "LINC01857 promotes the proliferation, migration, and invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6.", "journal": "Canadian journal of physiology and pharmacology", "date": "2022", "authors": "Chen S, Dai J, Wang W, Ren C", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" } ], "reference": [ { "type": "PubMed", "id": "35468304", "url": "https://glygen.org/publication/PubMed/35468304" } ] }, { "title": "High expression of HOXC6 predicts a poor prognosis and induces proliferation and inflammation in multiple myeloma cells.", "journal": "Genes & genomics", "date": "2023-05-18", "authors": "Li Zhihua, Wang Yaru, Hou Xiaoxu, Guo Luyao, Li Yanling, Ma Yanping, Ma Yanping", "evidence": [ { "database": "RefSeq", "id": "NP_004494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004494" } ], "reference": [ { "type": "PubMed", "id": "37202556", "url": "https://glygen.org/publication/PubMed/37202556" } ] }, { "title": "Cloning and expression of a new HOXC6 transcript encoding a repressing protein.", "journal": "Biochem. J.", "date": "1996", "authors": "Chariot A, Castronovo V, Le P, Gillet C, Sobel M E, Gielen J", "evidence": [ { "database": "UniProtKB", "id": "P09630", "url": "https://www.uniprot.org/uniprot/P09630" } ], "reference": [ { "type": "PubMed", "id": "8870653", "url": "https://glygen.org/publication/PubMed/8870653" } ] } ], "pathway": [ { "id": "hsa:3223", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3223", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GM16-1", "protein_name": "Homeo box C6", "gene_name": "Hoxc6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE", "length": 235 }, "evidence": [ { "id": "P09630", "url": "https://omabrowser.org/oma/group/P09630/", 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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"MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": 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"description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": 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hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, "tissue": { "name": "prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "31271305", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31271305" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { 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