{ "uniprot_canonical_ac": "P09467-1", "uniprot_ac": "P09467", "uniprot_id": "F16P1_HUMAN", "mass": { "chemical_mass": 36842.0, "monoisotopic_mass": 36842.0 }, "refseq": { "ac": "NP_000498", "name": "fructose-1,6-bisphosphatase 1", "summary": "Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" }, "gene_names": [ { "name": "FBP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09467", "id": "P09467" }, { "name": "FBP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498", "id": "NP_000498" }, { "name": "FBP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498", "id": "NP_000498" }, { "name": "FBP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09467", "id": "P09467" } ], "protein_names": [ { "name": "Fructose-1,6-bisphosphatase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09467" }, { "name": "3.1.3.11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09467" }, { "name": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09467" }, { "name": "FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; liver FBPase; growth-inhibiting protein 17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498", "id": "NP_000498" }, { "name": "FBPase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09467" }, { "name": "Liver FBPase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09467" }, { "name": "fructose-1,6-bisphosphatase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498", "id": "NP_000498" } ], "function": [ { "annotation": "1alpha,25(OH)2D3 ameliorates insulin resistance by alleviating gammadelta T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" }, { "database": "PubMed", "id": "37908738", "url": "https://glygen.org/publication/PubMed/37908738" } ] }, { "annotation": "AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.", "evidence": [ { "database": "RefSeq", "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" }, { "database": "PubMed", "id": "37565737", "url": "https://glygen.org/publication/PubMed/37565737" } ] }, { "annotation": "Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.", "evidence": [ { "database": "UniProtKB", "id": "A0A3B3IUC7", "url": "https://www.uniprot.org/uniprot/A0A3B3IUC7#function" }, { "database": "UniProtKB", "id": "ARBA00037308", "url": "https://www.uniprot.org/uniprot/ARBA00037308#function" }, { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467#function" }, { "database": "PubMed", "id": "16497803", "url": "https://glygen.org/publication/PubMed/16497803" }, { "database": "PubMed", "id": "22517657", "url": "https://glygen.org/publication/PubMed/22517657" }, { "database": "PubMed", "id": "18375435", "url": "https://glygen.org/publication/PubMed/18375435" } ] }, { "annotation": "FBP1 is a potential prognostic biomarker and correlated with tumor immunosuppressive microenvironment in glioblastoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" }, { "database": "PubMed", "id": "37507483", "url": "https://glygen.org/publication/PubMed/37507483" } ] }, { "annotation": "Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" } ] }, { "annotation": "Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3). Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" }, { "database": "PubMed", "id": "38049890", "url": "https://glygen.org/publication/PubMed/38049890" } ] }, { "annotation": "Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A). Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498" }, { "database": "PubMed", "id": "37388727", "url": "https://glygen.org/publication/PubMed/37388727" } ] } ], "disease": [ { "disease_id": "DOID:5204", "recommended_name": { "id": "DOID:5204", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5204", "name": "fructose-1,6-bisphosphatase deficiency", "description": "A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis." }, "synonyms": [ { "id": "DOID:5204", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5204", "name": "fructose 1 phosphate aldolase deficiency", "description": "" }, { "id": "DOID:5204", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5204", "name": "fructose-1,6-diphosphatase deficiency", "description": "" }, { "id": "MONDO:0009251", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009251", "name": "fructose-1,6-bisphosphatase deficiency", "description": "Fructose-1,6-biphosphatase (FBP) deficiency is a disorder of fructose metabolism characterized by recurrent episodes of fasting hypoglycemia with lactic acidosis, that may be life-threatening in neonates and infants." }, { "id": "MONDO:0009251", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009251", "name": "fructose 1 phosphate aldolase deficiency", "description": "" }, { "id": "MONDO:0009251", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009251", "name": "fructose-1,6-bisphosphatase deficiency", "description": "" }, { "id": "MONDO:0009251", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009251", "name": 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{ "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" }, { "database": "PubMed", "id": "8387495", "url": "https://glygen.org/publication/PubMed/8387495" } ] }, { "start_pos": 122, "end_pos": 122, "sequence_org": "D", "sequence_mut": "A", "comment": "Reduced activity.", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" }, { "database": "PubMed", "id": "8387495", "url": "https://glygen.org/publication/PubMed/8387495" } ] }, { "start_pos": 70, "end_pos": 70, "sequence_org": "Q", "sequence_mut": "E", "comment": "Increased affinity towards Ca(2+) and Mg(2+).", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" }, { "database": "PubMed", "id": "17350621", "url": "https://glygen.org/publication/PubMed/17350621" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "96.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "57.59", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "81.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "91.62", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "83.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "91.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "84.11", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "89.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165140", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165140" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P09467", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09467" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P09467", "url": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P09467", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09467" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://pharos.nih.gov/targets/P09467", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P09467", "url": "http://purl.obolibrary.org/obo/PR_P09467", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_000498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000498", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11064", "url": "https://www.rhea-db.org/rhea/11064", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3B3IUC7", "url": "https://www.uniprot.org/uniprot/A0A3B3IUC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B3IUC7-1", "url": "https://www.uniprot.org/uniprot/A0A3B3IUC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A804HJK9", "url": "https://www.uniprot.org/uniprot/A0A804HJK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A804HJK9-1", "url": "https://www.uniprot.org/uniprot/A0A804HJK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09467-1", "url": "https://www.uniprot.org/uniprot/P09467-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5VZC3", "url": "https://www.uniprot.org/uniprot/Q5VZC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5VZC3-1", "url": "https://www.uniprot.org/uniprot/Q5VZC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ", "length": 338, "header": "sp|P09467-1|F16P1_HUMAN Isoform 1 of Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=5 CANONICAL=P09467-1" }, "isoforms": [ { "isoform_ac": "A0A3B3IUC7-1", "url": "", "sequence": { "sequence": "MVLNALWSASRTSLGTGIIWGSCYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ", "length": 273, "header": "tr|A0A3B3IUC7-1|F16P1_HUMAN Computationally mapped isoform of Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=1 CANONICAL=P09467-1" }, "locus": { "chromosome": "9", "start_pos": 94638410, "end_pos": 94603384, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000648117.1", "url": "https://www.ensembl.org/id/ENST00000648117.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000498145.1", "url": "https://www.ensembl.org/id/ENSP00000498145.1" } ] } }, { "isoform_ac": "A0A804HJK9-1", "url": "", "sequence": { "sequence": "MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPFPESLAGVSGPQDEWCPCAATPAQRSPAHRSPHPGLGDPVRSSSLHLSFLV", "length": 240, "header": "tr|A0A804HJK9-1|F16P1_HUMAN Computationally mapped isoform of Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=1 CANONICAL=P09467-1" }, "locus": { "chromosome": "9", "start_pos": 94639310, "end_pos": 94606960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000682520.1", "url": "https://www.ensembl.org/id/ENST00000682520.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000507547.1", "url": "https://www.ensembl.org/id/ENSP00000507547.1" } ] } }, { "isoform_ac": "P09467-1", "url": "", "sequence": { "sequence": "MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ", "length": 338, "header": "sp|P09467-1|F16P1_HUMAN Isoform 1 of Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=5 CANONICAL=P09467-1" }, "locus": { "chromosome": "9", "start_pos": 94639310, "end_pos": 94603384, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375326.9", "url": "https://www.ensembl.org/id/ENST00000375326.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000364475.5", "url": "https://www.ensembl.org/id/ENSP00000364475.5" } ] } }, { "isoform_ac": "Q5VZC3-1", "url": "", "sequence": { "sequence": "MLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPP", "length": 151, "header": "tr|Q5VZC3-1|F16P1_HUMAN Computationally mapped isoform of Fructose-1,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=FBP1 PE=1 SV=1 CANONICAL=P09467-1" }, "locus": { "chromosome": "9", "start_pos": 94620409, "end_pos": 94606815, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414122.1", "url": "https://www.ensembl.org/id/ENST00000414122.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000411619.1", "url": "https://www.ensembl.org/id/ENSP00000411619.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P09467", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P09467" }, { "id": "26374642", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26374642" } ] } ], "phosphorylation": [ { "start_pos": 144, "end_pos": 144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P09467", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09467" }, { "database": "PubMed", "id": "32754266", "url": "https://glygen.org/publication/PubMed/32754266" } ], "site_lbl": "Ser144" }, { "start_pos": 170, "end_pos": 170, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P09467", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09467" }, { "database": "PubMed", "id": "36266488", "url": "https://glygen.org/publication/PubMed/36266488" } ], "site_lbl": "Ser170" }, { "start_pos": 216, "end_pos": 216, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "site_lbl": "Tyr216" }, { "start_pos": 245, "end_pos": 245, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "site_lbl": "Tyr245" }, { "start_pos": 265, "end_pos": 265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P09467", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09467" } ], "site_lbl": "Tyr265" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "cDNA sequence and kinetic properties of human lung fructose(1, 6)bisphosphatase.", "journal": "Arch. Biochem. Biophys.", "date": "1999", "authors": "Skalecki K, Rakus D, Wi\u015bniewski J R, Kolodziej J, Dzugaj A", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "reference": [ { "type": "PubMed", "id": "10222032", "url": "https://glygen.org/publication/PubMed/10222032" } ] }, { "title": "Structure, function and regulation of pyruvate carboxylase.", "journal": "The Biochemical journal", "date": "1999", "authors": "Jitrapakdee S, Wallace JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "10229653", "url": "https://glygen.org/publication/PubMed/10229653" } ] }, { "title": "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.", "journal": "Nature genetics", "date": "1999", "authors": "Kobayashi K, Sinasac DS, Iijima M, Boright AP, Begum L, Lee JR, Yasuda T, Ikeda S, Hirano R, Terazono H, Crackower MA, Kondo I, Tsui LC, Scherer SW, Saheki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "10369257", "url": "https://glygen.org/publication/PubMed/10369257" } ] }, { "title": "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.", "journal": "The Biochemical journal", "date": "1999", "authors": "Fiermonte G, Dolce V, Arrigoni R, Runswick MJ, Walker JE, Palmieri F", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "10585886", "url": "https://glygen.org/publication/PubMed/10585886" } ] }, { "title": "Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues.", "journal": "The Biochemical journal", "date": "2000", "authors": "Del Arco A, Agudo M, Satrustegui J", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "10642534", "url": "https://glygen.org/publication/PubMed/10642534" } ] }, { "title": "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells.", "journal": "Journal of andrology", "date": "2000", "authors": "Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "10714828", "url": "https://glygen.org/publication/PubMed/10714828" } ] }, { "title": "Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis.", "journal": "Annals of neurology", "date": "2001", "authors": "Comi GP, Fortunato F, Lucchiari S, Bordoni A, Prelle A, Jann S, Keller A, Ciscato P, Galbiati S, Chiveri L, Torrente Y, Scarlato G, Bresolin N", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "11506403", "url": "https://glygen.org/publication/PubMed/11506403" } ] }, { "title": "Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.", "journal": "The EMBO journal", "date": "2001", "authors": "Palmieri L, Pardo B, Lasorsa FM, del Arco A, Kobayashi K, Iijima M, Runswick MJ, Walker JE, Saheki T, Satrustegui J, Palmieri F", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "11566871", "url": "https://glygen.org/publication/PubMed/11566871" } ] }, { "title": "Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase 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Role of ASP-118 and ASP-121 in catalysis.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "el-Maghrabi MR, Gidh-Jain M, Austin LR, Pilkis SJ", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "reference": [ { "type": "PubMed", "id": "8387495", "url": "https://glygen.org/publication/PubMed/8387495" } ] }, { "title": "The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency.", "journal": "American journal of human genetics", "date": "1993", "authors": "Tsujino S, Shanske S, Sakoda S, Fenichel G, DiMauro S", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "8447317", "url": "https://glygen.org/publication/PubMed/8447317" } ] }, { "title": "Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.", "journal": "American journal of human genetics", "date": "1996", "authors": "Watanabe M, Zingg BC, Mohrenweiser HW", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "8571957", "url": "https://glygen.org/publication/PubMed/8571957" } ] }, { "title": "The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier.", "journal": "Biochimica et biophysica acta", "date": "1996", "authors": "Bisaccia F, Zara V, Capobianco L, Iacobazzi V, Mazzeo M, Palmieri F", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "8597574", "url": "https://glygen.org/publication/PubMed/8597574" } ] }, { "title": "Molecular cloning, sequencing and expression of the cDNA of the mitochondrial form of phosphoenolpyruvate carboxykinase from human liver.", "journal": "The Biochemical journal", "date": "1996", "authors": "Modaressi S, Christ B, Bratke J, Zahn S, Heise T, Jungermann K", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "8645161", "url": "https://glygen.org/publication/PubMed/8645161" } ] }, { "title": "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency.", "journal": "American journal of human genetics", "date": "1997", "authors": "Kikawa Y, Inuzuka M, Jin BY, Kaji S, Koga J, Yamamoto Y, Fujisawa K, Hata I, Nakai A, Shigematsu Y, Mizunuma H, Taketo A, Mayumi M, Sudo M", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" }, { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "9382095", "url": "https://glygen.org/publication/PubMed/9382095" } ] }, { "title": "Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib.", "journal": "FEBS letters", "date": "1997", "authors": "Gerin I, Veiga-da-Cunha M, Achouri Y, Collet JF, Van Schaftingen E", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "9428641", "url": "https://glygen.org/publication/PubMed/9428641" } ] }, { "title": "Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression.", "journal": "The Biochemical journal", "date": "1998", "authors": "Modaressi S, Brechtel K, Christ B, Jungermann K", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "9657976", "url": "https://glygen.org/publication/PubMed/9657976" } ] }, { "title": "Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase.", "journal": "Gene", "date": "1998", "authors": "Tillmann H, Eschrich K", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "9678974", "url": "https://glygen.org/publication/PubMed/9678974" } ] }, { "title": "A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic.", "journal": "American journal of human genetics", "date": "1998", "authors": "Veiga-da-Cunha M, Gerin I, Chen YT, de Barsy T, de Lonlay P, Dionisi-Vici C, Fenske CD, Lee PJ, Leonard JV, Maire I, McConkie-Rosell A, Schweitzer S, Vikkula M, Van Schaftingen E", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "9758626", "url": "https://glygen.org/publication/PubMed/9758626" } ] }, { "title": "Aggregation states of mitochondrial malate dehydrogenase.", "journal": "Protein science : a publication of the Protein Society", "date": "1998", "authors": "Sanchez SA, Hazlett TL, Brunet JE, Jameson DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263" } ], "reference": [ { "type": "PubMed", "id": "9792106", "url": "https://glygen.org/publication/PubMed/9792106" } ] } ], "pathway": [ { "id": "hsa:2203", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2203", "resource": "KEGG Pathway" }, { "id": "R-HSA-70263", "name": "Gluconeogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70263", "resource": "Reactome", "description": "Gluconeogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0U1RVK6-1", "protein_name": "fructose-bisphosphatase", "gene_name": "fbp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAASSGDSKMTQQRPAFDSNAMTLTRFVLQEQRKFKSATGDLSQLLNSIQTAIKATSSAVRKAGIAKLHGFAGDVNVQGEEVKKLDVLSNELFINMLKSSYTTCLMVSEENENVIEVEVEKQGKYIVCFDPLDGSSNIDCLVSIGSIFAIYRKKSDGPPTVEDALQPGNQLVAAGYALYGSATAIVLGLGSGVNGFTYDPAIGEFVLTDPNMRVPEKGKIYSINEGYAADWEDGVFNYIAAKKDPAKGKPYGARYVGSMVADVHRTIKYGGIFIYPATKSAPSGKLRLLYECVPMAYLMIQAGGLASDGKISILDIVPKKIHERSPIFLGSKSDVEEALSYLK", "length": 343 }, "evidence": [ { "id": "P09467", "url": "https://omabrowser.org/oma/group/P09467/", "database": "OMA" } ], "common_name": "Fruit fly" }, { 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"MPTLVNGPRRDSTEGFDTDIITLPRFIIEHQKQFKNATGDFTLVLNALQFAFKFVSHTIRRAELVNLVGLAGASNFTGDQQKKLDVLGDEIFINAMRASGIIKVLVSEEQEDLIVFPTNTGSYAVCCDPIDGSSNLDAGVSVGTIASIFRLLPDSSGTINDVLRCGKEMVAACYAMYGSSTHLVLTLGDGVDGFTLDTNLGEFILTHPNLRIPPQKAIYSINEGNTLYWNETIRTFIEKVKQPQADNNNKPFSARYVGSMVADVHRTFLYGGLFAYPCDKKSPNGKLRLLYEAFPMAFLMEQAGGKAVNDRGERILDLVPSHIHDKSSIWLGSSGEIDKFLDHIGKSQ", "length": 348 }, "evidence": [ { "id": "P09467", "url": "https://omabrowser.org/oma/group/P09467/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "P19112-1", "protein_name": "Fructose-1,6-bisphosphatase 1", "gene_name": "Fbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICDELF", "length": 363 }, "evidence": [ { "id": "45918623", "url": "http://www.informatics.jax.org/homology/45918623", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QXD6-1", "protein_name": "Fructose-1,6-bisphosphatase 1", "gene_name": "Fbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK", "length": 338 }, "evidence": [ { "id": "45918623", "url": "http://www.informatics.jax.org/homology/45918623", "database": "MGI" }, { "id": "P09467", "url": "https://omabrowser.org/oma/group/P09467/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "fructose 1,6-bisphosphate 1-phosphatase activity", "id": "GO:0042132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042132", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0048029", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "negative regulation of Ras protein signal transduction", "id": "GO:0046580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046580", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "dephosphorylation", "id": "GO:0016311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016311", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular response to raffinose", "id": "GO:0097403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097403", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "negative regulation of glycolytic process", "id": "GO:0045820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045820", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "fructose metabolic process", "id": "GO:0006000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006000", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "fructose 1,6-bisphosphate metabolic process", "id": "GO:0030388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030388", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular response to magnesium ion", "id": "GO:0071286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071286", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular response to phorbol 13-acetate 12-myristate", "id": "GO:1904628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904628", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "regulation of gluconeogenesis", "id": "GO:0006111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006111", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular hyperosmotic salinity response", "id": "GO:0071475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071475", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "fructose 6-phosphate metabolic process", "id": "GO:0006002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006002", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cellular hypotonic salinity response", "id": "GO:0071477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071477", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "sucrose biosynthetic process", "id": "GO:0005986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005986", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P09467", "url": "https://www.uniprot.org/uniprot/P09467" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11064", "name": "", "equation": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19112-1", "Q9Z1N1-1", "O00757-1", "P09467-1", "Q9QXD6-1", "P70695-1", "P09201-1", "Q6RYT0-1", "A0A0U1RVK6-1" ], "evidence": [ { "id": "11064", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11064" } ] }, { "id": "R-HSA-70479", "name": "FBP tetramers hydrolyze F1,6PP to Fru(6)P", "equation": "", "summary": "Cytosolic FBP (fructose-1,6-bisphosphatase) tetramers catalyze the physiologically irreversible hydrolysis of F1,6PP (fructose-1,6-bisphosphate) to form Fru(6)P (fructose-6-phosphate) and Pi (orthophosphate). In the body, two isoforms of the enzyme are expressed, one ubiquitous and one muscle-specific (Kikawa et al. 1997; Tillmann and Eschrich 1998).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P09467-1", "O00757-1" ], "evidence": [ { "id": "R-HSA-70479", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70479" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0U1RVK6", "gene_name": "fbp", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "A0A0U1RVK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0U1RVK6" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "A0A0U1RVK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0U1RVK6" } ] } ] }, { "uniprot_ac": "O00757", "gene_name": "FBP2", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "O00757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00757" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "O00757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00757" } ] } ] }, { "uniprot_ac": "P09201", "gene_name": "FBP1", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "P09201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09201" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "P09201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09201" } ] } ] }, { "uniprot_ac": "P09467", "gene_name": "FBP1", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "P09467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09467" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "P09467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09467" } ] } ] }, { "uniprot_ac": "P19112", "gene_name": "Fbp1", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "P19112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19112" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "P19112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19112" } ] } ] }, { "uniprot_ac": "P70695", "gene_name": "Fbp2", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "P70695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70695" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "P70695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70695" } ] } ] }, { "uniprot_ac": "Q6RYT0", "gene_name": "fbp", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "Q6RYT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6RYT0" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "Q6RYT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6RYT0" } ] } ] }, { "uniprot_ac": "Q9QXD6", "gene_name": "Fbp1", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "Q9QXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXD6" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "Q9QXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXD6" } ] } ] }, { "uniprot_ac": "Q9Z1N1", "gene_name": "Fbp2", "activity": [ { "ec_number": "3.1.3.11", "activity": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate.", "evidence": [ { "id": "Q9Z1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1N1" } ] }, { "ec_number": "3.1.3.11", "activity": "", "evidence": [ { "id": "Q9Z1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z1N1" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 144, 170, 216, 245, 265 ], "sequon_annotation_sites": [ { "start_pos": 65, "end_pos": 67 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { 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[] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 92 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }