{ "uniprot_canonical_ac": "P09402-1", "uniprot_ac": "P09402", "uniprot_id": "MLE_DICDI", "mass": { "chemical_mass": 16246.0, "monoisotopic_mass": 16246.0 }, "refseq": { "ac": "XP_642037", "name": "essential myosin light chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642037" }, "gene_names": [ { "name": "mlcE", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09402", "id": "P09402" }, { "name": "DDB_G0277859", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09402", "id": "P09402" }, { "name": "mlcB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09402", "id": "P09402" }, { "name": "mlcE", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642037", "id": "XP_642037" } ], "protein_names": [ { "name": "Myosin, essential light chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09402" }, { "name": "EMLC", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09402" }, { "name": "Myosin light chain alkali", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09402" }, { "name": "essential myosin light chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642037", "id": "XP_642037" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "mlcE", "url": "https://www.uniprot.org/uniprot/P09402", "locus": {} } ], "crossref": [ { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0277859", "url": "http://dictybase.org/gene/DDB_G0277859", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8621248", "url": "https://www.ncbi.nlm.nih.gov/gene/8621248", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0277859", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0277859", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QECFSIF", "url": "https://omabrowser.org/oma/group/QECFSIF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13405", "url": "http://pfam.xfam.org/family/PF13405", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "http://pfam.xfam.org/family/PF13499", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P09402", "url": "http://purl.obolibrary.org/obo/PR_P09402", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-5627123", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5627123", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_642037", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642037", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09402-1", "url": "https://www.uniprot.org/uniprot/P09402-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASADQIQECFSIFDKDNDGKVSVEDIGACLRSLGKSPTMADIEALKTEIGAKEFDINTLKSIYKKPNIKTPQEQQKEMLDAFKALDKEGHGTIQGAELRQLLTTLGDYLSTAEVDELFKEISVDSTTGAVSYASLVNTIVSGYPLGGF", "length": 150, "header": "sp|P09402-1|MLE_DICDI Isoform 1 of Myosin, essential light chain OS=Dictyostelium discoideum OX=44689 GN=mlcE PE=2 SV=2 CANONICAL=P09402-1" }, "isoforms": [ { "isoform_ac": "P09402-1", "url": "", "sequence": { "sequence": "MSASADQIQECFSIFDKDNDGKVSVEDIGACLRSLGKSPTMADIEALKTEIGAKEFDINTLKSIYKKPNIKTPQEQQKEMLDAFKALDKEGHGTIQGAELRQLLTTLGDYLSTAEVDELFKEISVDSTTGAVSYASLVNTIVSGYPLGGF", "length": 150, "header": "sp|P09402-1|MLE_DICDI Isoform 1 of Myosin, essential light chain OS=Dictyostelium discoideum OX=44689 GN=mlcE PE=2 SV=2 CANONICAL=P09402-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Dictyostelium discoideum essential myosin light chain: gene structure and characterization.", "journal": "Cell Motil. Cytoskeleton", "date": "1991", "authors": "Pollenz R S, Chisholm R L", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "reference": [ { "type": "PubMed", "id": "1751970", "url": "https://glygen.org/publication/PubMed/1751970" } ] }, { "title": "Dictyostelium discoideum myosin: isolation and characterization of cDNAs encoding the essential light chain.", "journal": "Mol. Cell. Biol.", "date": "1988", "authors": "Chisholm R L, Rushforth A M, Pollenz R S, Kuczmarski E R, Tafuri S R", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "reference": [ { "type": "PubMed", "id": "2451126", "url": "https://glygen.org/publication/PubMed/2451126" } ] } ], "pathway": [ { "id": "ddi:DDB_G0277859", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0277859", "resource": "KEGG Pathway" }, { "id": "R-DDI-5627123", "name": "RHO GTPases activate PAKs", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5627123", "resource": "Reactome", "description": "RHO GTPases activate PAKs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "myosin filament assembly", "id": "GO:0031034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031034", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "sorocarp development", "id": "GO:0030587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030587", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "actomyosin", "id": "GO:0042641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042641", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "myosin II complex", "id": "GO:0016460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016460", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "myosin heavy chain binding", "id": "GO:0032036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032036", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" }, { "name": "cytoskeletal motor activator activity", "id": "GO:0140660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140660", "evidence": [ { "database": "UniProtKB", "id": "P09402", "url": "https://www.uniprot.org/uniprot/P09402" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }