{ "uniprot_canonical_ac": "P09172-1", "uniprot_ac": "P09172", "uniprot_id": "DOPO_HUMAN", "mass": { "chemical_mass": 69065.0, "monoisotopic_mass": 69065.0 }, "refseq": { "ac": "NP_000778", "name": "dopamine beta-hydroxylase precursor", "summary": "The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" }, "gene_names": [ { "name": "DBH", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09172", "id": "P09172" }, { "name": "DBH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778", "id": "NP_000778" }, { "name": "DBM; ORTHYP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778", "id": "NP_000778" } ], "protein_names": [ { "name": "Dopamine beta-hydroxylase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09172" }, { "name": "1.14.17.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09172" }, { "name": "Dopamine beta-monooxygenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09172" }, { "name": "dopamine beta-hydroxylase (dopamine beta-monooxygenase)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778", "id": "NP_000778" }, { "name": "dopamine beta-hydroxylase precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778", "id": "NP_000778" } ], "function": [ { "annotation": "Association between 19-bp Insertion/Deletion Polymorphism of Dopamine beta-Hydroxylase and Autism Spectrum Disorder in Thai Patients. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" }, { "database": "PubMed", "id": "36143905", "url": "https://glygen.org/publication/PubMed/36143905" } ] }, { "annotation": "Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia.", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" }, { "database": "PubMed", "id": "32896003", "url": "https://glygen.org/publication/PubMed/32896003" } ] }, { "annotation": "Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172#function" }, { "database": "PubMed", "id": "8546710", "url": "https://glygen.org/publication/PubMed/8546710" }, { "database": "PubMed", "id": "27148966", "url": "https://glygen.org/publication/PubMed/27148966" }, { "database": "PubMed", "id": "7961964", "url": "https://glygen.org/publication/PubMed/7961964" }, { "database": "PubMed", "id": "3443096", "url": "https://glygen.org/publication/PubMed/3443096" }, { "database": "UniProtKB", "id": "Q5T382", "url": "https://www.uniprot.org/uniprot/Q5T382#function" }, { "database": "UniProtKB", "id": "ARBA00037327", "url": "https://www.uniprot.org/uniprot/ARBA00037327#function" } ] }, { "annotation": "Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort.", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" }, { "database": "PubMed", "id": "37493923", "url": "https://glygen.org/publication/PubMed/37493923" } ] }, { "annotation": "Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas.", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" }, { "database": "PubMed", "id": "34743284", "url": "https://glygen.org/publication/PubMed/34743284" } ] }, { "annotation": "Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DBetaH) Polymorphisms with Susceptibility to Dementia (SADEM Study).", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" }, { "database": "PubMed", "id": "37148523", "url": "https://glygen.org/publication/PubMed/37148523" } ] }, { "annotation": "The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" } ] } ], "disease": [ { "disease_id": "DOID:0090145", "recommended_name": { "id": "DOID:0090145", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090145", "name": "dopamine beta-hydroxylase deficiency", "description": "An inherited metabolic disorder characterized by decreased beta-hydroxylation of dopamine in nerves resulting in impaired autonomic noradrenergic neurotransmission and clinical features including severely decreased norepinephrine levels, orthostatic hypotension, ptosis, nasal stuffiness, and delayed eye opening that has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the dopamine beta-hydroxylase gene (DBH) on chromosome 9q34." }, "synonyms": [ { "id": "DOID:0090145", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090145", "name": "congenital dopamine beta-hydroxylase deficiency", "description": "" }, { "id": "DOID:0090145", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090145", "name": "noradrenaline deficiency", "description": "" }, { "id": "DOID:0090145", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090145", "name": "norepinephrine deficiency", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "orthostatic hypotension 1", "description": "A very rare primary monoamine neurotransmitter synthesis disorder with norepinephrine and adrenaline deficiency that leads to young-onset severe orthostatic hypotension and eyelid ptosis." }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "congenital dopamine beta-hydroxylase deficiency", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "dopamine beta-hydroxylase deficiency", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "noradrenaline deficiency", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "norepinephrine deficiency", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "orthostatic hypotension 1, due to DBH deficiency", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "dopamine BETA-HYDROXYLASE deficiency, congenital", "description": "" }, { "id": "MONDO:0009123", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009123", "name": "dopamine beta hydroxylase deficiency", "description": "" }, { "id": "MIM:223360", "resource": "MIM", "url": "https://www.omim.org/entry/223360", "name": "Orthostatic hypotension 1", "description": "Orthostatic hypotension 1" } ], "evidence": [ { "id": "223360", "database": "MIM", "url": "https://www.omim.org/entry/223360" } ] } ], "snv": [ { "evidence": [ { "id": "rs755302704", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755302704" }, { "id": "rs755302704", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755302704" }, { "id": "rs755302704", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755302704" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 66, "end_pos": 66, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SYT->NYT); 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"database": "Ensembl Peptide", "id": "ENSP00000376776.2", "url": "https://www.ensembl.org/id/ENSP00000376776.2" } ] } }, { "isoform_ac": "Q5T382-1", "url": "", "sequence": { "sequence": "ALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAK", "length": 256, "header": "tr|Q5T382-1|Q5T382_HUMAN Computationally mapped isoform of Dopamine beta-hydroxylase OS=Homo sapiens OX=9606 GN=DBH PE=1 SV=2 CANONICAL=P09172-1" }, "locus": { "chromosome": "9", "start_pos": 133643589, "end_pos": 133636378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000263611.3", "url": "https://www.ensembl.org/id/ENST00000263611.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000263611.3", "url": "https://www.ensembl.org/id/ENSP00000263611.3" } ] } } ], "glycosylation": [ { 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"glytoucan_ac": "G43089EG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "1933", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1933" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G48414YA", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "1933", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1933" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G58804QW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "1933", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1933" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G74728JK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "1933", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1933" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G86795LJ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "1933", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1933" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine Complex", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P09172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "id": "16335952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16335952" }, { "id": "27152332", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27152332" }, { "id": "19139490", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19139490" }, { "id": "4ZEL", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4ZEL" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 344, "start_aa": "Asn", "end_pos": 344, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn344", "evidence": [ { "id": "P09172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "id": "27152332", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27152332" }, { "id": "4ZEL", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4ZEL" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 566, "start_aa": "Asn", "end_pos": 566, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn566", "evidence": [ { "id": "P09172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "id": "27152332", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27152332" }, { "id": "4ZEL", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4ZEL" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 64, "start_aa": "Asn", "end_pos": 64, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn64", "evidence": [ { "id": "P09172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "id": "27152332", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27152332" }, { "id": "4ZEL", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4ZEL" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Characterization of single-nucleotide polymorphisms in coding regions of human genes.", "journal": "Nature genetics", "date": "1999", "authors": "Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "10391209", "url": "https://glygen.org/publication/PubMed/10391209" } ] }, { "title": "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.", "journal": "Nature genetics", "date": "1999", "authors": "Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "10391210", "url": "https://glygen.org/publication/PubMed/10391210" } ] }, { "title": "No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).", "journal": "American journal of medical genetics", "date": "1999", "authors": "Williams HJ, Bray N, Murphy KC, Cardno AG, Jones LA, Owen MJ", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "10490716", "url": "https://glygen.org/publication/PubMed/10490716" } ] }, { "title": "Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency.", "journal": "American journal of medical genetics", "date": "2002", "authors": "Kim CH, Zabetian CP, Cubells JF, Cho S, Biaggioni I, Cohen BM, Robertson D, Kim KS", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" }, { "database": "dbSNP", "id": "rs267606761", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs267606761" } ], "reference": [ { "type": "PubMed", "id": "11857564", "url": "https://glygen.org/publication/PubMed/11857564" } ] }, { "title": "Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis.", "journal": "Biochemistry", "date": "1992", "authors": "Sumi-Ichinose C, Ichinose H, Takahashi E, Hori T, Nagatsu T", "evidence": [ { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "1540578", "url": "https://glygen.org/publication/PubMed/1540578" } ] }, { "title": "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.", "journal": "Journal of proteome research", "date": "2005", "authors": "Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "16335952", "url": "https://glygen.org/publication/PubMed/16335952" } ] }, { "title": "Expression of two forms of human dopamine-beta-hydroxylase in COS cells.", "journal": "Neuroscience letters", "date": "1991", "authors": "Ishii A, Kobayashi K, Kiuchi K, Nagatsu T", "evidence": [ { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "1857555", "url": "https://glygen.org/publication/PubMed/1857555" } ] }, { "title": "A strategy for precise and large scale identification of core fucosylated glycoproteins.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Jia W, Lu Z, Fu Y, Wang HP, Wang LH, Chi H, Yuan ZF, Zheng ZB, Song LN, Han HH, Liang YM, Wang JL, Cai Y, Zhang YK, Deng YL, Ying WT, He SM, Qian XH", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "19139490", "url": "https://glygen.org/publication/PubMed/19139490" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase.", "journal": "Biochemical and biophysical research communications", "date": "1989", "authors": "Ichinose H, Kurosawa Y, Titani K, Fujita K, Nagatsu T", "evidence": [ { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "2590185", "url": "https://glygen.org/publication/PubMed/2590185" } ] }, { "title": "Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine beta-Hydroxylase Knockout Mice.", "journal": "PloS one", "date": "2016", "authors": "Cubells JF, Schroeder JP, Barrie ES, Manvich DF, Sadee W, Berg T, Mercer K, Stowe TA, Liles LC, Squires KE, Mezher A, Curtin P, Perdomo DL, Szot P, Weinshenker D", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "27148966", "url": "https://glygen.org/publication/PubMed/27148966" } ] }, { "title": "The crystal structure of human dopamine beta-hydroxylase at 2.9 A resolution.", "journal": "Science advances", "date": "2016", "authors": "Vendelboe TV, Harris P, Zhao Y, Walter TS, Harlos K, El Omari K, Christensen HE", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172#ptm_processing" }, { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "27152332", "url": "https://glygen.org/publication/PubMed/27152332" } ] }, { "title": "Human dopamine beta-hydroxylase gene: two mRNA types having different 3'-terminal regions are produced through alternative polyadenylation.", "journal": "Nucleic Acids Res.", "date": "1989", "authors": "Kobayashi K, Kurosawa Y, Fujita K, Nagatsu T", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "2922261", "url": "https://glygen.org/publication/PubMed/2922261" } ] }, { "title": "Large-scale intact glycopeptide identification by Mascot database search.", "journal": "Scientific reports", "date": "2018", "authors": "Bollineni RC, Koehler CJ, Gislefoss RE, Anonsen JH, Thiede B", "evidence": [ { "database": "GlyConnect", "id": "1933", "url": "https://glyconnect.expasy.org/browser/proteins/1933" } ], "reference": [ { "type": "PubMed", "id": "29391424", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "title": "Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia.", "journal": "Human psychopharmacology", "date": "2020", "authors": "Hui L, Hu WM, Zhu ZH, Gao ST, Han M, Fan Y, Tian Q, Yin XY, Yuan Y, Jiang CX, Yin GZ, Jia QF, Zhang XY", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" } ], "reference": [ { "type": "PubMed", "id": "32896003", "url": "https://glygen.org/publication/PubMed/32896003" } ] }, { "title": "Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "Kaneda N, Ichinose H, Kobayashi K, Oka K, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T", "evidence": [ { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "3372503", "url": "https://glygen.org/publication/PubMed/3372503" } ] }, { "title": "The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.", "journal": "The EMBO journal", "date": "1987", "authors": "Lamouroux A, Vigny A, Faucon Biguet N, Darmon MC, Franck R, Henry JP, Mallet J", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" }, { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "3443096", "url": "https://glygen.org/publication/PubMed/3443096" } ] }, { "title": "Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas.", "journal": "Endocrine pathology", "date": "2021", "authors": "Kimura N, Shiga K, Kaneko KI, Oki Y, Sugisawa C, Saito J, Tawara S, Akahori H, Sogabe S, Yamashita T, Takekoshi K, Naruse M, Katabami T", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" } ], "reference": [ { "type": "PubMed", "id": "34743284", "url": "https://glygen.org/publication/PubMed/34743284" } ] }, { "title": "Association between 19-bp Insertion/Deletion Polymorphism of Dopamine beta-Hydroxylase and Autism Spectrum Disorder in Thai Patients.", "journal": "Medicina (Kaunas, Lithuania)", "date": "2022", "authors": "Wongpaiboonwattana W, Hnoonual A, Limprasert P", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" } ], "reference": [ { "type": "PubMed", "id": "36143905", "url": "https://glygen.org/publication/PubMed/36143905" } ] }, { "title": "Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (D\u0392H) Polymorphisms with Susceptibility to Dementia (SADEM Study).", "journal": "Molecular neurobiology", "date": "2023-05-06", "authors": "Ju\u00e1rez-Cedillo Teresa, Mart\u00ednez-Rodr\u00edguez Nancy, Fragoso Jos\u00e9 Manuel, Islas-P\u00e9rez Valentin, L\u00f3pez-Mart\u00ednez Amara, Valle-Medina Antonio", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" } ], "reference": [ { "type": "PubMed", "id": "37148523", "url": "https://glygen.org/publication/PubMed/37148523" } ] }, { "title": "Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort.", "journal": "Molecular neurobiology", "date": "2023-07-26", "authors": "Punchaichira Toyanji Joseph, Kukshal Prachi, Bhatia Triptish, Deshpande Smita Neelkanth, Thelma B K", "evidence": [ { "database": "RefSeq", "id": "NP_000778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000778" } ], "reference": [ { "type": "PubMed", "id": "37493923", "url": "https://glygen.org/publication/PubMed/37493923" } ] }, { "title": "Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Kobayashi K, Morita S, Mizuguchi T, Sawada H, Yamada K, Nagatsu I, Fujita K, Nagatsu T", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" }, { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "7961964", "url": "https://glygen.org/publication/PubMed/7961964" } ] }, { "title": "Four isoforms of tyrosine hydroxylase are expressed in human brain.", "journal": "Neuroscience", "date": "1993", "authors": "Lewis DA, Melchitzky DS, Haycock JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-209905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905" } ], "reference": [ { "type": "PubMed", "id": "8101641", "url": "https://glygen.org/publication/PubMed/8101641" } ] }, { "title": "Expression of human dopamine beta-hydroxylase in Drosophila Schneider 2 cells.", "journal": "The Biochemical journal", "date": "1996", "authors": "Li B, Tsing S, Kosaka AH, Nguyen B, Osen EG, Bach C, Chan H, Barnett J", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "reference": [ { "type": "PubMed", "id": "8546710", "url": "https://glygen.org/publication/PubMed/8546710" } ] } ], "pathway": [ { "id": "hsa:1621", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1621", "resource": "KEGG Pathway" }, { "id": "R-HSA-209905", "name": "Catecholamine biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209905", "resource": "Reactome", "description": "Catecholamine biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q05754-1", "protein_name": "Dopamine beta-hydroxylase", "gene_name": "Dbh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYHIPLDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNESEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSAVEEPDPRCPIRQTRGPAGPFVVITHGGRH", "length": 620 }, "evidence": [ { "id": "45916939", "url": "http://www.informatics.jax.org/homology/45916939", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q64237-1", "protein_name": "Dopamine beta-hydroxylase", "gene_name": "Dbh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQAHLSHQPCWSSLPSPSVREAASMYGTAVAIFLVILVAALRGSEPPESPFPYHIPLDPEGILELSWNVSYVQEIIHFQLQVQGLRAGVLFGMSDRGEMENADLIMLWTDGDRAYFADAWSDRKGQIHLDSQQDYQLLQAQRTRDGLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQRVQLLKSEVPTPSMPEDVQTMDIRAPDILIPDNETTYWCYITELPPRFPRHHIIMYEAIVTEGNEALVHHMEVFQCAAESEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAGVPFGGPGSSPFLRLEVHYHNPRKIQGRQDSSGIRLHYTATLRRYDAGIMELGLVYTPLMAIPPQETAFVLTGYCTDKCTQMALQDSGIHIFASQLHTHLTGRKVVTVLARDGQERKVVNRDNHYSPHFQEIRMLKKVVTVYPGDVLITSCTYNTENKTLATVGGFGILEEMCVNYVHYYPQTELELCKSAVDDGFLQKYFHMVNRFSSEEVCTCPQASVPQQFSSVPWNSFNRDMLKALYDYAPISMHCNKTSAVRFPGEWNLQPLPKITSTLEEPTPRCPIRQTQSPANPTVPITTEADAE", "length": 622 }, "evidence": [ { "id": "45916939", "url": "http://www.informatics.jax.org/homology/45916939", "database": "MGI" }, { "id": "P09172", "url": "https://omabrowser.org/oma/group/P09172/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86B61-1", "protein_name": "Tyramine beta-hydroxylase", "gene_name": "Tbh", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLKIPLQLSSQDGIWPARFARRLHHHHQLAYHHHKQEQQQQQQQQQQQQAKQKQKQNGVQQGRSPTFMPVMLLLLMATLLTRPLSAFSNRLSDTKLHEIYLDDKEIKLSWMVDWYKQEVLFHLQNAFNEQHRWFYLGFSKRGGLADADICFFENQNGFFNAVTDTYTSPDGQWVRRDYQQDCEVFKMDEFTLAFRRKFDTCDPLDLRLHEGTMYVVWARGETELALEDHQFALPNVTAPHEAGVKMLQLLRADKILIPETELDHMEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPGIVHHMEVFHCEAGEHEEIPLYNGDCEQLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGFNPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGYCVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKPRVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFIYMKRTEHQHGVHLNGARSSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSWEGVAATPVQIRIPIHRKLCPNYNPLWLKPLEKGDCDLLGECIY", "length": 670 }, "evidence": [ { "id": "P09172", "url": "https://omabrowser.org/oma/group/P09172/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 13, "go_terms": [ { "name": "transport vesicle membrane", "id": "GO:0030658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030658", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "chromaffin granule membrane", "id": "GO:0042584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042584", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "chromaffin granule lumen", "id": "GO:0034466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034466", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "secretory granule lumen", "id": "GO:0034774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034774", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "secretory granule membrane", "id": "GO:0030667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030667", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "L-ascorbic acid binding", "id": "GO:0031418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031418", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "dopamine beta-monooxygenase activity", "id": "GO:0004500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004500", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 23, "go_terms": [ { "name": "norepinephrine biosynthetic process", "id": "GO:0042421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042421", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "locomotory behavior", "id": "GO:0007626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007626", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "visual learning", "id": "GO:0008542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008542", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "blood vessel remodeling", "id": "GO:0001974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "response to amphetamine", "id": "GO:0001975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001975", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "behavioral response to ethanol", "id": "GO:0048149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048149", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "positive regulation of vasoconstriction", "id": "GO:0045907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045907", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "vasoconstriction", "id": "GO:0042310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042310", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "leukocyte migration", "id": "GO:0050900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050900", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001236", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "dopamine catabolic process", "id": "GO:0042420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042420", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "fear response", "id": "GO:0042596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042596", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "response to pain", "id": "GO:0048265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048265", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "leukocyte mediated immunity", "id": "GO:0002443", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002443", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "octopamine biosynthetic process", "id": "GO:0006589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006589", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "homoiothermy", "id": "GO:0042309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042309", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "maternal behavior", "id": "GO:0042711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042711", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "regulation of vascular endothelial cell proliferation", "id": "GO:1905562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905562", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" }, { "name": "regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904705", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "P09172", "url": "https://www.uniprot.org/uniprot/P09172" }, { "database": "PubMed", "id": "27152332", "url": "https://glygen.org/publication/PubMed/27152332" }, { "database": "PubMed", "id": "8546710", "url": "https://glygen.org/publication/PubMed/8546710" } ] } ], "interactions": [], "reactions": [ { "id": "19117", "name": "", "equation": "dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q05754-1", "P09172-1", "Q64237-1" ], "evidence": [ { "id": "19117", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19117" } ] }, { "id": "R-HSA-209891", "name": "Dopamine is oxidised to noradrenaline", "equation": "", "summary": "Dopamine beta-hydroxylase (DBH; dopamine beta-monooxygenase) is a copper-containing glycoprotein consisting of four identical subunits and catalyzes the oxidation of dopamine to norepinephrine. It requires ascorbic acid as an electron donor. DBH is localized in the norepinephrinergic and epinephrinergic neurons in the central nervous system. The enzyme exists in the secretory vesicles as both soluble and membrane-bound forms. The soluble form is secreted with catecholamines by exocytosis whereas the membrane-bound form is recycled into the vesicles.", "cellular_location": "secretory granule lumen", "input_participant_list": [ "R-ALL-351593", "R-ALL-351595" ], "output_participant_list": [ "R-ALL-351597", "R-ALL-351599" ], "enzyme_list": [ "P09172-1" ], "evidence": [ { "id": "R-HSA-209891", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-209891" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-351593", "participant_name": "O2 [secretory granule lumen]", "crossref": [ { "id": "8145133", "database": "PubChem Substance", "url": "" }, { "id": "C00007", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001377", "database": "HMDB Metabolite", "url": "" }, { "id": "15379", "database": "ChEBI", "url": "" }, { "id": "C00007", "database": "COMPOUND", "url": "" }, { "id": "15379", "database": "ChEBI", "url": "" }, { "id": "8145133", "database": "PubChem Substance", "url": "" 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