{ "uniprot_canonical_ac": "P08910-1", "uniprot_ac": "P08910", "uniprot_id": "ABHD2_HUMAN", "mass": { "chemical_mass": 48315.0, "monoisotopic_mass": 48315.0 }, "refseq": { "ac": "NP_008942", "name": "monoacylglycerol lipase ABHD2 isoform 1", "summary": "This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, "gene_names": [ { "name": "ABHD2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08910", "id": "P08910" }, { "name": "ABHD2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942", "id": "NP_008942" }, { "name": "HS1-2; LABH2; PHPS1-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942", "id": "NP_008942" }, { "name": "LABH2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P08910", "id": "P08910" } ], "protein_names": [ { "name": "Monoacylglycerol lipase ABHD2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08910" }, { "name": "2-arachidonoylglycerol hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "3.1.1.23", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "3.1.1.6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "3.1.1.79", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "Abhydrolase domain-containing protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "Acetylesterase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "Lung alpha/beta hydrolase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "Progesterone-sensitive lipase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "Protein PHPS1-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08910" }, { "name": "lung alpha/beta hydrolase 2; alpha/beta hydrolase domain containing protein 2; abhydrolase domain-containing protein 2; protein PHPS1-2; testicular tissue protein Li 6; acetylesterase; 2-arachidonoylglycerol hydrolase; monoacylglycerol lipase ABHD2; progesterone-sensitive lipase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942", "id": "NP_008942" }, { "name": "monoacylglycerol lipase ABHD2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942", "id": "NP_008942" } ], "function": [ { "annotation": "Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, { "database": "PubMed", "id": "38197032", "url": "https://glygen.org/publication/PubMed/38197032" } ] }, { "annotation": "Circular RNA circ_0079593 enhances malignant melanoma progression by the regulation of the miR-573/ABHD2 axis.", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, { "database": "PubMed", "id": "33648800", "url": "https://glygen.org/publication/PubMed/33648800" } ] }, { "annotation": "Membrane Cholesterol Inhibits Progesterone-Mediated Sperm Function through the Possible Involvement of ABHD2. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, { "database": "PubMed", "id": "37298205", "url": "https://glygen.org/publication/PubMed/37298205" } ] }, { "annotation": "Our results showed that the ABHD2 was expressed in atherosclerotic lesions, and that the ABHD2 expression was significantly higher in the patients with UA than with SA.", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, { "database": "PubMed", "id": "17980156", "url": "https://glygen.org/publication/PubMed/17980156" } ] }, { "annotation": "Patients with selective immunoglobulin (Ig)A deficiency have a highly significant increase of homozygousity of HS1.2 allele *1, with an increase of 2.6-fold; the HS1.2 polymorphism influences Ig seric production, but not IgG switch.", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, { "database": "PubMed", "id": "20007591", "url": "https://glygen.org/publication/PubMed/20007591" } ] }, { "annotation": "Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910#function" }, { "database": "UniProtKB", "id": "Q9QXM0", "url": "https://www.uniprot.org/uniprot/Q9QXM0#function" }, { "database": "PubMed", "id": "26989199", "url": "https://glygen.org/publication/PubMed/26989199" }, { "database": "PubMed", "id": "27247428", "url": "https://glygen.org/publication/PubMed/27247428" } ] }, { "annotation": "These results show that joint tests of main effects and gene-gene interaction reveal associations at some novel loci that were missed when considering main effects alone.", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" }, { "database": "PubMed", "id": "28813576", "url": "https://glygen.org/publication/PubMed/28813576" } ] }, { "annotation": "This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1428468695", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1428468695" }, { "id": "rs1428468695", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1428468695" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 136, "end_pos": 136, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NHS->SHS).", "chr_id": "15", "chr_pos": "89155403", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N136", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P08910", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08910" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 138, "end_pos": 138, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NHS->NHN).", "chr_id": "15", "chr_pos": "89155409", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S138", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P08910", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08910" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 193, "end_pos": 193, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KKT->NKT).", "chr_id": "15", "chr_pos": "89175852", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "K193", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs763085663", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763085663" }, { "id": "rs763085663", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763085663" }, { "id": "rs763085663", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763085663" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 290, "end_pos": 290, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "15", "chr_pos": "89188245", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D290", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1277864577", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1277864577" }, { "id": "rs1277864577", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1277864577" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 343, "end_pos": 343, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAA->NAT).", "chr_id": "15", "chr_pos": "89193265", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A343", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "79.32", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "85.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "88.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "86.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "89.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "67.08", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "86.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "81.51", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000140526", "url": 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P08910", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08910" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08910" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "common_name": "Human" } ], "gene": [ { "name": "ABHD2", "url": "https://www.uniprot.org/uniprot/P08910", "locus": { "chromosome": "15", "start_pos": 89202355, "end_pos": 89087459, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000140526", "url": "https://www.ensembl.org/id/ENSG00000140526" } ] } } ], "crossref": [ { "id": "ENSG00000140526", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000140526", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P08910", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08910", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "ABHD2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABHD2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "11057", "url": "https://www.ncbi.nlm.nih.gov/gene/11057", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "18717", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=18717", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "612196", "url": "http://www.omim.org/entry/612196", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P08910", "url": "https://www.nextprot.org/entry/NX_P08910", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "DHCRRFY", "url": "https://omabrowser.org/oma/group/DHCRRFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4242155at2759", "url": "http://www.orthodb.org/?query=4242155at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10794", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10794", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10794:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10794:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "http://pfam.xfam.org/family/PF00561", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P08910", "url": "https://pharos.nih.gov/targets/P08910", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P08910", "url": "http://purl.obolibrary.org/obo/PR_P08910", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12044", "url": "https://www.rhea-db.org/rhea/12044", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "12957", "url": "https://www.rhea-db.org/rhea/12957", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "26132", "url": "https://www.rhea-db.org/rhea/26132", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47348", "url": "https://www.rhea-db.org/rhea/47348", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47392", "url": "https://www.rhea-db.org/rhea/47392", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "H3BMT2", "url": "https://www.uniprot.org/uniprot/H3BMT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BMT2-1", "url": "https://www.uniprot.org/uniprot/H3BMT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BN19", "url": "https://www.uniprot.org/uniprot/H3BN19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BN19-1", "url": "https://www.uniprot.org/uniprot/H3BN19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BUZ6", "url": "https://www.uniprot.org/uniprot/H3BUZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BUZ6-1", "url": "https://www.uniprot.org/uniprot/H3BUZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08910-1", "url": "https://www.uniprot.org/uniprot/P08910-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE", "length": 425, "header": "sp|P08910-1|ABHD2_HUMAN Isoform 1 of Monoacylglycerol lipase ABHD2 OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1 CANONICAL=P08910-1" }, "isoforms": [ { "isoform_ac": "H3BMT2-1", "url": "", "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVG", "length": 123, "header": "tr|H3BMT2-1|ABHD2_HUMAN Computationally mapped isoform of Monoacylglycerol lipase ABHD2 OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1 CANONICAL=P08910-1" }, "locus": { "chromosome": "15", "start_pos": 89151851, "end_pos": 89116328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000565066.5", "url": "https://www.ensembl.org/id/ENST00000565066.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454531.1", "url": "https://www.ensembl.org/id/ENSP00000454531.1" } ] } }, { "isoform_ac": "H3BN19-1", "url": "", "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFL", "length": 55, "header": "tr|H3BN19-1|H3BN19_HUMAN Computationally mapped isoform of Abhydrolase domain containing 2, acylglycerol lipase OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=8 CANONICAL=P08910-1" }, "locus": { "chromosome": "15", "start_pos": 89116492, "end_pos": 89116328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569550.5", "url": "https://www.ensembl.org/id/ENST00000569550.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454645.1", "url": "https://www.ensembl.org/id/ENSP00000454645.1" } ] } }, { "isoform_ac": "H3BUZ6-1", "url": "", "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVIC", "length": 131, "header": "tr|H3BUZ6-1|H3BUZ6_HUMAN Computationally mapped isoform of Abhydrolase domain containing 2, acylglycerol lipase OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1 CANONICAL=P08910-1" }, "locus": { "chromosome": "15", "start_pos": 89155389, "end_pos": 89116328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569411.5", "url": "https://www.ensembl.org/id/ENST00000569411.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000457882.1", "url": "https://www.ensembl.org/id/ENSP00000457882.1" } ] } }, { "isoform_ac": "P08910-1", "url": "", "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE", "length": 425, "header": "sp|P08910-1|ABHD2_HUMAN Isoform 1 of Monoacylglycerol lipase ABHD2 OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1 CANONICAL=P08910-1" }, "locus": { "chromosome": "15", "start_pos": 89195420, "end_pos": 89116328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000565973.5", "url": "https://www.ensembl.org/id/ENST00000565973.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000455639.1", "url": "https://www.ensembl.org/id/ENSP00000455639.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 136, "start_aa": "Asn", "end_pos": 136, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn136", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.", "journal": "Biochemical and biophysical research communications", "date": "2008", "authors": "Miyata K, Nakayama M, Mizuta S, Hokimoto S, Sugamura K, Oshima S, Oike Y, Sugiyama S, Ogawa H, Yamamura K", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ], "reference": [ { "type": "PubMed", "id": "17980156", "url": "https://glygen.org/publication/PubMed/17980156" } ] }, { "title": "Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2009", "authors": "Giambra V, Cianci R, Lolli S, Mattioli C, Tampella G, Cattalini M, Kilic SS, Pandolfi F, Plebani A, Frezza D", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ], "reference": [ { "type": "PubMed", "id": "20007591", "url": "https://glygen.org/publication/PubMed/20007591" } ] }, { "title": "Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone.", "journal": "Science (New York, N.Y.)", "date": "2016", "authors": "Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "reference": [ { "type": "PubMed", "id": "26989199", "url": "https://glygen.org/publication/PubMed/26989199" } ] }, { "title": "Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase.", "journal": "Bioscience reports", "date": "2016", "authors": "M NK, V B S C T, G K V, B CS, Guntupalli S, J S B", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "reference": [ { "type": "PubMed", "id": "27247428", "url": "https://glygen.org/publication/PubMed/27247428" } ] }, { "title": "Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family.", "journal": "Nucleic Acids Res.", "date": "1988", "authors": "Rapiejko PJ, George ST, Malbon CC", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "reference": [ { "type": "PubMed", "id": "2843827", "url": "https://glygen.org/publication/PubMed/2843827" } ] }, { "title": "Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1.", "journal": "Investigative ophthalmology & visual science", "date": "2017", "authors": "Persad PJ, Heid IM, Weeks DE, Baird PN, de Jong EK, Haines JL, Pericak-Vance MA, Scott WK", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ], "reference": [ { "type": "PubMed", "id": "28813576", "url": "https://glygen.org/publication/PubMed/28813576" } ] }, { "title": "Circular RNA circ_0079593 enhances malignant melanoma progression by the regulation of the miR-573/ABHD2 axis.", "journal": "Journal of dermatological science", "date": "2021", "authors": "Zhao F, Jia Z, Feng Y, Li Z, Feng J", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ], "reference": [ { "type": "PubMed", "id": "33648800", "url": "https://glygen.org/publication/PubMed/33648800" } ] }, { "title": "Membrane Cholesterol Inhibits Progesterone-Mediated Sperm Function through the Possible Involvement of ABHD2.", "journal": "International journal of molecular sciences", "date": "2023-05-25", "authors": "De Toni Luca, Cosci Ilaria, Sabovic Iva, Di Nisio Andrea, Guidolin Diego, Pedrucci Federica, Finocchi Federica, Dall'Acqua Stefano, Foresta Carlo, Ferlin Alberto, Garolla Andrea", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ], "reference": [ { "type": "PubMed", "id": "37298205", "url": "https://glygen.org/publication/PubMed/37298205" } ] }, { "title": "Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-\u03b2.", "journal": "International journal of chronic obstructive pulmonary disease", "date": "2024", "authors": "Lv Mei-Yu, Jin Ling-Ling, Sang Xi-Qiao, Shi Wen-Chao, Qiang Li-Xia, Lin Qing-Yan, Jin Shou-De", "evidence": [ { "database": "RefSeq", "id": "NP_008942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008942" } ], "reference": [ { "type": "PubMed", "id": "38197032", "url": "https://glygen.org/publication/PubMed/38197032" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D4A7W1-1", "protein_name": "Abhydrolase domain containing 2, acylglycerol lipase", "gene_name": "Abhd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDVTMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE", "length": 425 }, "evidence": [ { "id": "45925171", "url": "http://www.informatics.jax.org/homology/45925171", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QXM0-1", "protein_name": "Monoacylglycerol lipase ABHD2", "gene_name": "Abhd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKRTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE", "length": 425 }, "evidence": [ { "id": "45925171", "url": "http://www.informatics.jax.org/homology/45925171", "database": "MGI" }, { "id": "P08910", "url": "https://omabrowser.org/oma/group/P08910/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "smooth muscle cell migration", "id": "GO:0014909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014909", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "acylglycerol catabolic process", "id": "GO:0046464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046464", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "acrosome reaction", "id": "GO:0007340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "response to progesterone", "id": "GO:0032570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032570", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "steroid hormone mediated signaling pathway", "id": "GO:0043401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043401", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "medium-chain fatty acid catabolic process", "id": "GO:0051793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051793", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell migration", "id": "GO:0014912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014912", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "medium-chain fatty acid biosynthetic process", "id": "GO:0051792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051792", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "acylglycerol lipase activity", "id": "GO:0047372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047372", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "nuclear steroid receptor activity", "id": "GO:0003707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003707", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "hormone binding", "id": "GO:0042562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042562", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "triglyceride lipase activity", "id": "GO:0004806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004806", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "hormone-sensitive lipase activity", "id": "GO:0033878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033878", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "acetylesterase activity", "id": "GO:0008126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008126", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" }, { "name": "sperm plasma membrane", "id": "GO:0097524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097524", "evidence": [ { "database": "UniProtKB", "id": "P08910", "url": "https://www.uniprot.org/uniprot/P08910" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12044", "name": "", "equation": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "Q9QZH8-1", "Q06000-1", "P04634-1", "P54318-1", "Q8VBX1-1", "P07867-1", "P15304-1", "P27657-1", "P0C548-1", "P54316-1", "P0C1S9-1", "O54728-1", "P08910-1", "P22760-1", "P19835-1", "P54315-1", "Q9Y5X9-1", "P54317-1", "Q17RR3-1", "P07098-1", "P16233-1", "Q05469-1", "P06858-1", "P11150-1", "Q9NST1-1", "Q96AD5-1", "P41247-1", "Q6P1J6-1", "Q8NCG7-1", "Q7Z6Z6-1", "Q99PG0-1", "Q9QXM0-1", "Q64285-1", "P54310-1", "P27656-1", "P17892-1", "Q9WVG5-1", "Q9CPP7-1", "P11152-1", "Q6P8U6-1", "Q91WW7-1", "Q8BJ56-1", "Q91WC9-1", "Q32LZ8-1", "Q3TTY0-1", "P25641-1", "P54857-1", "P40308-1", "P40471-1", "Q12043-1", "P36165-1", "P38139-1", "Q06522-1", "P47145-1", "Q9VMM8-1" ], "evidence": [ { "id": "12044", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12044" } ] }, { "id": "12957", "name": "", "equation": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "P08910-1", "P19835-1", "Q9QXM0-1", "Q64285-1" ], "evidence": [ { "id": "12957", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12957" } ] }, { "id": "26132", "name": "", "equation": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "P97612-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "P15304-1", "P07687-1", "Q8N2K0-1", "P08910-1", "Q9BV23-1", "O95870-1", "O00519-1", "Q99685-1", "O00748-1", "P23141-1", "P07099-1", "Q05469-1", "Q8IY17-4", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "Q9QXM0-1", "O08914-1", "O35678-1", "P54310-1", "Q3TRM4-1", "Q8VCC2-1", "Q9D379-1" ], "evidence": [ { "id": "26132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26132" } ] }, { "id": "47348", "name": "", "equation": "a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "P08910-1", "P19835-1", "Q9QXM0-1", "Q64285-1" ], "evidence": [ { "id": "47348", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47348" } ] }, { "id": "47392", "name": "", "equation": "H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08910-1", "Q9QXM0-1" ], "evidence": [ { "id": "47392", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47392" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00519", "gene_name": "FAAH", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "O00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00519" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "O00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00519" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "O00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00519" } ] } ] }, { "uniprot_ac": "O00748", "gene_name": "CES2", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] } ] }, { "uniprot_ac": "O08914", "gene_name": "Faah", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] } ] }, { "uniprot_ac": "O35678", "gene_name": "Mgll", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "O35678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35678" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "O35678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35678" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O95870", "gene_name": "ABHD16A", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] } ] }, { "uniprot_ac": "P04634", "gene_name": "Lipf", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P04634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04634" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P04634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04634" } ] } ] }, { "uniprot_ac": "P06858", "gene_name": "LPL", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] } ] }, { "uniprot_ac": "P07098", "gene_name": "LIPF", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098" } ] } ] }, { "uniprot_ac": "P07099", "gene_name": "EPHX1", "activity": [ { "ec_number": "3.3.2.9", "activity": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol.", "evidence": [ { "id": "P07099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07099" } ] }, { "ec_number": "3.3.2.9", "activity": "", "evidence": [ { "id": "P07099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07099" } ] } ] }, { "uniprot_ac": "P07687", "gene_name": "Ephx1", "activity": [ { "ec_number": "3.3.2.9", "activity": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol.", "evidence": [ { "id": "P07687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07687" } ] }, { "ec_number": "3.3.2.9", "activity": "", "evidence": [ { "id": "P07687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07687" } ] } ] }, { "uniprot_ac": "P07867", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] } ] }, { "uniprot_ac": "P07882", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] } ] }, { "uniprot_ac": "P08910", "gene_name": "ABHD2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] } ] }, { "uniprot_ac": "P0C1S9", "gene_name": "Daglb", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] }, { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] } ] }, { "uniprot_ac": "P0C548", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] } ] }, { "uniprot_ac": "P11150", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] } ] }, { "uniprot_ac": "P11152", "gene_name": "Lpl", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] } ] }, { "uniprot_ac": "P15304", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] } ] }, { "uniprot_ac": "P16233", "gene_name": "PNLIP", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P16233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16233" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P16233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16233" } ] } ] }, { "uniprot_ac": "P17892", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] } ] }, { "uniprot_ac": "P19835", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] } ] }, { "uniprot_ac": "P22760", "gene_name": "AADAC", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P22760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22760" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P22760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22760" } ] } ] }, { "uniprot_ac": "P23141", "gene_name": "CES1", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] } ] }, { "uniprot_ac": "P25641", "gene_name": "ATG15", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P25641", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25641" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P25641", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25641" } ] } ] }, { "uniprot_ac": "P27656", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] } ] }, { "uniprot_ac": "P27657", "gene_name": "Pnlip", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27657" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27657" } ] } ] }, { "uniprot_ac": "P36165", "gene_name": "TGL4", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] } ] }, { "uniprot_ac": "P38139", "gene_name": "LDH1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P38139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38139" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P38139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38139" } ] } ] }, { "uniprot_ac": "P40308", "gene_name": "TGL3", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P40308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40308" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P40308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40308" } ] } ] }, { "uniprot_ac": "P40471", "gene_name": "AYR1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] }, { "ec_number": "1.1.1.101", "activity": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+).", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] }, { "ec_number": "1.1.1.101", "activity": "", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] } ] }, { "uniprot_ac": "P41247", "gene_name": "PNPLA4", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] } ] }, { "uniprot_ac": "P47145", "gene_name": "LIH1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P47145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47145" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P47145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47145" } ] } ] }, { "uniprot_ac": "P54310", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] } ] }, { "uniprot_ac": "P54315", "gene_name": "PNLIPRP1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54315" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54315" } ] } ] }, { "uniprot_ac": "P54316", "gene_name": "Pnliprp1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54316" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54316" } ] } ] }, { "uniprot_ac": "P54317", "gene_name": "PNLIPRP2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] } ] }, { "uniprot_ac": "P54318", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] } ] }, { "uniprot_ac": "P54857", "gene_name": "TGL2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54857" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54857" } ] } ] }, { "uniprot_ac": "P97612", "gene_name": "Faah", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] } ] }, { "uniprot_ac": "Q05469", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] } ] }, { "uniprot_ac": "Q06000", "gene_name": "Lpl", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] } ] }, { "uniprot_ac": "Q06522", "gene_name": "", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q06522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06522" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q06522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06522" } ] } ] }, { "uniprot_ac": "Q12043", "gene_name": "TGL5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q12043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12043" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q12043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12043" } ] } ] }, { "uniprot_ac": "Q17RR3", "gene_name": "PNLIPRP3", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q17RR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q17RR3" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q17RR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q17RR3" } ] } ] }, { "uniprot_ac": "Q32LZ8", "gene_name": "Pnpla5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q32LZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32LZ8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q32LZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32LZ8" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q5XI64", "gene_name": "Abhd6", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q5XI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI64" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q5XI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI64" } ] } ] }, { "uniprot_ac": "Q64285", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] } ] }, { "uniprot_ac": "Q6AYT7", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] } ] }, { "uniprot_ac": "Q6MG55", "gene_name": "Abhd16a", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6MG55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MG55" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q6MG55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MG55" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q6MG55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MG55" } ] } ] }, { "uniprot_ac": "Q6P1J6", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q6P8U6", "gene_name": "Pnlip", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P8U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P8U6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P8U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P8U6" } ] } ] }, { "uniprot_ac": "Q7Z6Z6", "gene_name": "PNPLA5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q7Z6Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q7Z6Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z6" } ] } ] }, { "uniprot_ac": "Q8BJ56", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] } ] }, { "uniprot_ac": "Q8IY17", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] } ] }, { "uniprot_ac": "Q8N2K0", "gene_name": "ABHD12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] } ] }, { "uniprot_ac": "Q8NCG7", "gene_name": "DAGLB", "activity": [ { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCG7" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "Q8NCG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCG7" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCG7" } ] } ] }, { "uniprot_ac": "Q8R2Y0", "gene_name": "Abhd6", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q8R2Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R2Y0" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q8R2Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R2Y0" } ] } ] }, { "uniprot_ac": "Q8R431", "gene_name": "Mgll", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q8R431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R431" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q8R431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R431" } ] } ] }, { "uniprot_ac": "Q8VBX1", "gene_name": "Lipg", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBX1" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8VBX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBX1" } ] }, { "ec_number": "3.1.1.3", 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