{
"uniprot_canonical_ac": "P08575-3",
"uniprot_ac": "P08575",
"uniprot_id": "PTPRC_HUMAN",
"mass": {
"chemical_mass": 147486.0,
"monoisotopic_mass": 147486.0
},
"refseq": {
"ac": "NP_002829",
"name": "receptor-type tyrosine-protein phosphatase C isoform 1 precursor",
"summary": "The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
},
"gene_names": [
{
"name": "PTPRC",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P08575",
"id": "P08575"
},
{
"name": "B220; CD45; CD45R; GP180; IMD105; L-CA; LCA; LY5; T200",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829",
"id": "NP_002829"
},
{
"name": "CD45",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P08575",
"id": "P08575"
},
{
"name": "PTPRC",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829",
"id": "NP_002829"
}
],
"protein_names": [
{
"name": "Receptor-type tyrosine-protein phosphatase C",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P08575"
},
{
"name": "3.1.3.48",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P08575"
},
{
"name": "L-CA",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P08575"
},
{
"name": "Leukocyte common antigen",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P08575"
},
{
"name": "T200",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P08575"
},
{
"name": "protein tyrosine phosphatase, receptor type, c polypeptide; T200 glycoprotein; CD45 antigen; T200 leukocyte common antigen; glycoprotein 180",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829",
"id": "NP_002829"
},
{
"name": "receptor-type tyrosine-protein phosphatase C isoform 1 precursor",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829",
"id": "NP_002829"
}
],
"function": [
{
"annotation": "(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575#function"
},
{
"database": "PubMed",
"id": "22174689",
"url": "https://glygen.org/publication/PubMed/22174689"
}
]
},
{
"annotation": "CD45RA and CD45RO Are Regulated in a Cell-Type Specific Manner in Inflammation and Sepsis. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
},
{
"database": "PubMed",
"id": "37508538",
"url": "https://glygen.org/publication/PubMed/37508538"
}
]
},
{
"annotation": "CD45[-] erythroid progenitor cells promote lymph node metastasis in gastric cancer by inducing a hybrid epithelial/mesenchymal state in lymphatic endothelial cells.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
},
{
"database": "PubMed",
"id": "37676622",
"url": "https://glygen.org/publication/PubMed/37676622"
}
]
},
{
"annotation": "Eosinophilic allergic rhinitis is strongly associated with the CD45RB[lo] subset of CD161[+] Th2 cells that secretes IL-2, IL-3, IL-4, IL-5, IL-9, and IL-13.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
},
{
"database": "PubMed",
"id": "37551093",
"url": "https://glygen.org/publication/PubMed/37551093"
}
]
},
{
"annotation": "PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
},
{
"database": "PubMed",
"id": "37996489",
"url": "https://glygen.org/publication/PubMed/37996489"
}
]
},
{
"annotation": "Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
},
{
"database": "PubMed",
"id": "37973964",
"url": "https://glygen.org/publication/PubMed/37973964"
}
]
},
{
"annotation": "Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575#function"
},
{
"database": "PubMed",
"id": "2845400",
"url": "https://glygen.org/publication/PubMed/2845400"
},
{
"database": "PubMed",
"id": "11909961",
"url": "https://glygen.org/publication/PubMed/11909961"
}
]
},
{
"annotation": "The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829"
}
]
}
],
"disease": [
{
"disease_id": "MONDO:0021571",
"recommended_name": {
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "multiple sclerosis, susceptibility to 1",
"description": ""
},
"synonyms": [
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "MS1",
"description": ""
},
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "multiple sclerosis, disease progression, modifier of",
"description": ""
},
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "multiple sclerosis, susceptibility to, 1",
"description": ""
},
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "MS",
"description": ""
},
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "disseminated sclerosis",
"description": ""
},
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "multiple sclerosis, susceptibility to",
"description": ""
},
{
"id": "MONDO:0021571",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0021571",
"name": "susceptibility to multiple sclerosis",
"description": ""
},
{
"id": "MIM:126200",
"resource": "MIM",
"url": "https://www.omim.org/entry/126200",
"name": "Multiple sclerosis",
"description": "Multiple sclerosis"
}
],
"evidence": [
{
"id": "126200",
"database": "MIM",
"url": "https://www.omim.org/entry/126200"
}
]
},
{
"disease_id": "MONDO:0800104",
"recommended_name": {
"id": "MONDO:0800104",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0800104",
"name": "immunodeficiency 105",
"description": "Any immunodeficiency disease which the cause of the disease is a mutation in the PTPRC gene."
},
"synonyms": [
{
"id": "MONDO:0800104",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0800104",
"name": "IMD105",
"description": ""
},
{
"id": "MONDO:0800104",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0800104",
"name": "SCID, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive",
"description": ""
},
{
"id": "MONDO:0800104",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0800104",
"name": "severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive",
"description": ""
},
{
"id": "MIM:619924",
"resource": "MIM",
"url": "https://www.omim.org/entry/619924",
"name": "Immunodeficiency 105",
"description": "Immunodeficiency 105"
}
],
"evidence": [
{
"id": "619924",
"database": "MIM",
"url": "https://www.omim.org/entry/619924"
}
]
}
],
"snv": [
{
"evidence": [
{
"id": "P08575",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08575"
},
{
"id": "rs4915154",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs4915154"
},
{
"id": "rs4915154",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs4915154"
},
{
"id": "rs4915154",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs4915154"
},
{
"id": "rs4915154",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs4915154#frequency_tab"
},
{
"id": "rs4915154",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs4915154"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 193,
"end_pos": 193,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "A",
"comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (3); o-glyco-site-loss (T->A).",
"chr_id": "1",
"chr_pos": "198702524",
"ref_nt": "A",
"alt_nt": "G",
"minor_allelic_frequency": "",
"site_lbl": "T193",
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
},
{
"disease_id": "DOID:2531",
"recommended_name": {
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematologic cancer",
"description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes."
},
"synonyms": [
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "Hematologic malignancy",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "Hematologic neoplasm",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "Hematological tumors",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "blood cancer",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic and lymphoid system tumor",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic cancer",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic neoplasm",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic tumors",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "malignant hematopoietic neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
},
{
"disease_id": "DOID:0090014",
"recommended_name": {
"id": "DOID:0090014",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0090014",
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"description": "A severe combined immunodeficiency characterized by being T cell-negative, B cell-positive and natural killer cell-positive and that has_material_basis_in homozygous or compound heterozygous mutation in the IL7R gene on chromosome 5p13 or the CD45 gene on chromosome 1q31."
},
"synonyms": [
{
"id": "DOID:0090014",
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"url": "http://disease-ontology.org/term/DOID:0090014",
"name": "autosomal recessive T cell-negative, B-cell positive, NK cell-positive SCID",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "immunodeficiency 104",
"description": "A severe combined immunodeficiency characterized by being T cell-negative, B cell-positive and natural killer cell-positive and that has material basis in homozygous or compound heterozygous mutation in the IL7R gene on chromosome 5p13 or the CD45 gene on chromosome 1q31."
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "IMD104",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "autosomal recessive T cell-negative, B-cell negative, NK cell-positive SCID",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "autosomal recessive T cell-negative, B-cell positive, NK cell-positive SCID",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "severe combined immunodeficiency, T-cell negative, B-cell/natural killer cell-positive type",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive",
"description": ""
},
{
"id": "MONDO:0012163",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012163",
"name": "SCID, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive",
"description": ""
},
{
"id": "MIM:608971",
"resource": "MIM",
"url": "https://www.omim.org/entry/608971",
"name": "Immunodeficiency 104",
"description": "Immunodeficiency 104"
}
]
}
],
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"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1268528022",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1268528022"
},
{
"id": "rs1268528022",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1268528022"
},
{
"id": "rs1268528022",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1268528022"
}
],
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],
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"end_pos": 1002,
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"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DES->NES).",
"chr_id": "1",
"chr_pos": "198749481",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D1002",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1412205853",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1412205853"
},
{
"id": "rs1412205853",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1412205853#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 1021,
"end_pos": 1021,
"sequence_org": "S",
"sequence_mut": "F",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAS->NAF).",
"chr_id": "1",
"chr_pos": "198749539",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S1021",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs757944444",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757944444"
},
{
"id": "rs757944444",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757944444"
},
{
"id": "rs757944444",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs757944444"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 1040,
"end_pos": 1040,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KET->NET).",
"chr_id": "1",
"chr_pos": "198750539",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K1040",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P08575",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08575"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 1091,
"end_pos": 1091,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KDT->NDT).",
"chr_id": "1",
"chr_pos": "198752314",
"ref_nt": "A",
"alt_nt": "C",
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"site_lbl": "K1091",
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
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},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
],
"keywords": [
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"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "P08575",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08575"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 1112,
"end_pos": 1112,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KDS->NDS).",
"chr_id": "1",
"chr_pos": "198752599",
"ref_nt": "A",
"alt_nt": "C",
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"site_lbl": "K1112",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "P08575",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08575"
}
],
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"end_pos": 1115,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "R",
"sequence_mut": "Q",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).",
"chr_id": "1",
"chr_pos": "198752607",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "R1115",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
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}
]
},
{
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"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
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},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
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},
{
"id": "MIM:109800",
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"name": "Bladder cancer",
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}
]
},
{
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"url": "http://disease-ontology.org/term/DOID:9256",
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"synonyms": [
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"resource": "MONDO",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
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},
{
"id": "MIM:114500",
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}
]
},
{
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},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
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},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
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}
]
}
],
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},
{
"evidence": [
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},
{
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],
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},
{
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},
{
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],
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"end_pos": 1126,
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"chr_id": "1",
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"alt_nt": "null",
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"site_lbl": "S1126",
"keywords": [
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},
{
"evidence": [
{
"id": "P08575",
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"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P08575"
}
],
"glycoeffect": [
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],
"start_pos": 1305,
"end_pos": 1305,
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"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NQG->NQS).",
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"chr_pos": "198756173",
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"alt_nt": "A",
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"site_lbl": "G1305",
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{
"disease_id": "DOID:4159",
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"resource": "Disease Ontology",
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},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
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{
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}
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},
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{
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{
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],
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},
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{
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{
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},
{
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},
{
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{
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{
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{
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},
{
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{
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{
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{
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{
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{
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},
{
"id": "MONDO:0012163",
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"url": "https://monarchinitiative.org/disease/MONDO:0012163",
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{
"id": "MONDO:0012163",
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},
{
"id": "MONDO:0012163",
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{
"id": "MONDO:0012163",
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{
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},
{
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{
"id": "MONDO:0012163",
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{
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{
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{
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},
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},
{
"evidence": [
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{
"id": "DOID:4159",
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{
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}
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},
{
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{
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},
{
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{
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},
{
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],
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{
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{
"id": "MONDO:0012159",
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},
{
"id": "MONDO:0012159",
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{
"id": "MONDO:0012159",
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{
"id": "MONDO:0012942",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
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},
{
"id": "MONDO:0013631",
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"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
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{
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{
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{
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{
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{
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{
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{
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"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T99",
"keywords": [
"ebi",
"germline"
]
}
],
"mutagenesis": [
{
"start_pos": 853,
"end_pos": 853,
"sequence_org": "C",
"sequence_mut": "S",
"comment": "Loss of activity. Abolishes interaction with SKAP1.",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
},
{
"database": "PubMed",
"id": "11909961",
"url": "https://glygen.org/publication/PubMed/11909961"
}
]
}
],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "72.05",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "88.94",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "89.78",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "49.96",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "84.09",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "94.19",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "65.18",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "82.23",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "77.16",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "89.94",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "89.73",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "74.72",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "83.73",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000081237",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000081237"
}
]
}
],
"expression_disease": [
{
"significant": "No",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
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{
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{
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{
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"resource": "MONDO",
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"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "gastric neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
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{
"database": "BioXpress",
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],
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{
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},
"synonyms": [
{
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"resource": "Disease Ontology",
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},
{
"id": "DOID:11054",
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"name": "tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
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},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
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{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
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{
"disease_id": "DOID:11934",
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
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"url": "http://disease-ontology.org/term/DOID:1324",
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{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
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],
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{
"disease_id": "DOID:1324",
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},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
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},
{
"id": "MONDO:0012159",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
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"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P08575",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08575"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
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"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "P08575",
"url": "https://www.ebi.ac.uk/intact/interactors/id:P08575*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR000242",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000242",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR000387",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000387",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR003595",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR003595",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR003961",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR003961",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR013783",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR013783",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR016130",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR016130",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR016335",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR016335",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR024739",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR024739",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR029021",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR029021",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR036116",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR036116",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:5788",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5788",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "126200",
"url": "http://www.omim.org/entry/126200",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "151460",
"url": "http://www.omim.org/entry/151460",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "619924",
"url": "http://www.omim.org/entry/619924",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_P08575",
"url": "https://www.nextprot.org/entry/NX_P08575",
"database": "neXtProt",
"categories": [
"Protein",
"Organism-specific"
]
},
{
"id": "P08575",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08575",
"database": "O-GlcNAc Database",
"categories": [
"Glycoproteomics"
]
},
{
"id": "ISANKPC",
"url": "https://omabrowser.org/oma/group/ISANKPC/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "2875525at2759",
"url": "http://www.orthodb.org/?query=2875525at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR19134",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19134",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR19134:SF539",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19134:SF539",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "1YGR",
"url": "https://www.rcsb.org/structure/1YGR",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1YGU",
"url": "https://www.rcsb.org/structure/1YGU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5FMV",
"url": "https://www.rcsb.org/structure/5FMV",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5FN6",
"url": "https://www.rcsb.org/structure/5FN6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5FN7",
"url": "https://www.rcsb.org/structure/5FN7",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00041",
"url": "http://pfam.xfam.org/family/PF00041",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00102",
"url": "http://pfam.xfam.org/family/PF00102",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF12453",
"url": "http://pfam.xfam.org/family/PF12453",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF12567",
"url": "http://pfam.xfam.org/family/PF12567",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "P08575",
"url": "https://pharos.nih.gov/targets/P08575",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR:000054484",
"url": "https://proconsortium.org/app/entry/PR:000054484",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000054485",
"url": "https://proconsortium.org/app/entry/PR:000054485",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000054486",
"url": "https://proconsortium.org/app/entry/PR:000054486",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR_P08575",
"url": "http://purl.obolibrary.org/obo/PR_P08575",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-202427",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202427",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-416700",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-6798695",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_002829",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002829",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "10684",
"url": "https://www.rhea-db.org/rhea/10684",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "P08575",
"url": "DISABLED",
"database": "UniCarbKB",
"categories": [
"Glycoproteomics"
]
},
{
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-10",
"url": "https://www.uniprot.org/uniprot/P08575-10",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-3",
"url": "https://www.uniprot.org/uniprot/P08575-3",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-4",
"url": "https://www.uniprot.org/uniprot/P08575-4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-5",
"url": "https://www.uniprot.org/uniprot/P08575-5",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-6",
"url": "https://www.uniprot.org/uniprot/P08575-6",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-7",
"url": "https://www.uniprot.org/uniprot/P08575-7",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-8",
"url": "https://www.uniprot.org/uniprot/P08575-8",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P08575-9",
"url": "https://www.uniprot.org/uniprot/P08575-9",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1306,
"header": "sp|P08575-3|PTPRC_HUMAN Isoform 3 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"isoforms": [
{
"isoform_ac": "P08575-10",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1193,
"header": "sp|P08575-10|PTPRC_HUMAN Isoform 10 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {}
},
{
"isoform_ac": "P08575-3",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1306,
"header": "sp|P08575-3|PTPRC_HUMAN Isoform 3 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {
"chromosome": "1",
"start_pos": 198756178,
"end_pos": 198639269,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000442510.8",
"url": "https://www.ensembl.org/id/ENST00000442510.8"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000411355.3",
"url": "https://www.ensembl.org/id/ENSP00000411355.3"
}
]
}
},
{
"isoform_ac": "P08575-4",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1145,
"header": "sp|P08575-4|PTPRC_HUMAN Isoform 4 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {
"chromosome": "1",
"start_pos": 198756178,
"end_pos": 198639269,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000348564.11",
"url": "https://www.ensembl.org/id/ENST00000348564.11"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000306782.7",
"url": "https://www.ensembl.org/id/ENSP00000306782.7"
}
]
}
},
{
"isoform_ac": "P08575-5",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1258,
"header": "sp|P08575-5|PTPRC_HUMAN Isoform 5 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {}
},
{
"isoform_ac": "P08575-6",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1259,
"header": "sp|P08575-6|PTPRC_HUMAN Isoform 6 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {}
},
{
"isoform_ac": "P08575-7",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1240,
"header": "sp|P08575-7|PTPRC_HUMAN Isoform 7 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {}
},
{
"isoform_ac": "P08575-8",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1211,
"header": "sp|P08575-8|PTPRC_HUMAN Isoform 8 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {
"chromosome": "1",
"start_pos": 198756178,
"end_pos": 198639269,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000697631.1",
"url": "https://www.ensembl.org/id/ENST00000697631.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000513363.1",
"url": "https://www.ensembl.org/id/ENSP00000513363.1"
}
]
}
},
{
"isoform_ac": "P08575-9",
"url": "",
"sequence": {
"sequence": "MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS",
"length": 1192,
"header": "sp|P08575-9|PTPRC_HUMAN Isoform 9 of Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3 CANONICAL=P08575-3"
},
"locus": {}
}
],
"glycosylation": [
{
"glytoucan_ac": "G22310AV",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 1019,
"start_aa": "Asn",
"end_pos": 1019,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn1019",
"evidence": [
{
"id": "339",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/339"
},
{
"id": "29391424",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29391424"
}
]
},
{
"glytoucan_ac": "G52527GH",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 1019,
"start_aa": "Asn",
"end_pos": 1019,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn1019",
"evidence": [
{
"id": "339",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/339"
},
{
"id": "29391424",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29391424"
}
]
},
{
"glytoucan_ac": "G22310AV",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 1124,
"start_aa": "Asn",
"end_pos": 1124,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn1124",
"evidence": [
{
"id": "339",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/339"
},
{
"id": "29391424",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29391424"
}
]
},
{
"glytoucan_ac": "G57321FI",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "AKLNPTPGSNAISDVPG",
"relation": "attached",
"comment": "Data provided by GlycoDomainViewer",
"start_pos": 134,
"start_aa": "Ala",
"end_pos": 150,
"end_aa": "Gly",
"evidence": [
{
"id": "P08575",
"database": "UniCarbKB",
"url": ""
},
{
"id": "23584533",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/23584533"
},
{
"id": "10.1038/emboj.2013.79",
"database": "DOI",
"url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79"
}
]
},
{
"glytoucan_ac": "G53434XO",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "",
"start_pos": 167,
"start_aa": "Thr",
"end_pos": 167,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr167",
"evidence": [
{
"id": "P08575",
"database": "UniCarbKB",
"url": ""
},
{
"id": "30459171",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/30459171"
}
]
},
{
"glytoucan_ac": "G58001LT",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "",
"start_pos": 167,
"start_aa": "Thr",
"end_pos": 167,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr167",
"evidence": [
{
"id": "P08575",
"database": "UniCarbKB",
"url": ""
},
{
"id": "30459171",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/30459171"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 176,
"start_aa": "Ser",
"end_pos": 176,
"end_aa": "Ser",
"residue": "Ser",
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"evidence": [
{
"id": "P08575",
"database": "UniCarbKB",
"url": ""
},
{
"id": "30459171",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/30459171"
}
]
},
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 185,
"start_aa": "Ser",
"end_pos": 185,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser185",
"evidence": [
{
"id": "P08575",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08575"
},
{
"id": "34931806",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/34931806"
},
{
"id": "27655845",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/27655845"
},
{
"id": "21300897",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/21300897"
},
{
"id": "35132862",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/35132862"
},
{
"id": "29351928",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29351928"
}
]
},
{
"glytoucan_ac": "",
"type": "N-linked",
"subtype": "",
"site_category": "predicted",
"site_seq": "N",
"relation": "attached",
"comment": "N-linked (GlcNAc...) asparagine",
"start_pos": 186,
"start_aa": "Asn",
"end_pos": 186,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn186",
"evidence": [
{
"id": "P08575",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08575#ptm_processing"
}
]
},
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "O-GlcNAcylation",
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"start_aa": "Thr",
"end_pos": 187,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr187",
"evidence": [
{
"id": "P08575",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08575"
},
{
"id": "34931806",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/34931806"
},
{
"id": "27655845",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/27655845"
},
{
"id": "21300897",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/21300897"
},
{
"id": "35132862",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/35132862"
},
{
"id": "29351928",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29351928"
}
]
},
{
"glytoucan_ac": "",
"type": "N-linked",
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"site_category": "predicted",
"site_seq": "N",
"relation": "attached",
"comment": "N-linked (GlcNAc...) asparagine",
"start_pos": 192,
"start_aa": "Asn",
"end_pos": 192,
"end_aa": "Asn",
"residue": "Asn",
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"evidence": [
{
"id": "P08575",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08575#ptm_processing"
}
]
},
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
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"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 193,
"start_aa": "Thr",
"end_pos": 193,
"end_aa": "Thr",
"residue": "Thr",
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"evidence": [
{
"id": "P08575",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08575"
},
{
"id": "34931806",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/34931806"
},
{
"id": "27655845",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/27655845"
},
{
"id": "21300897",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/21300897"
},
{
"id": "35132862",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/35132862"
},
{
"id": "29351928",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29351928"
}
]
},
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
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"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 194,
"start_aa": "Ser",
"end_pos": 194,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser194",
"evidence": [
{
"id": "P08575",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08575"
},
{
"id": "34931806",
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"url": "https://glygen.org/publication/PubMed/34931806"
},
{
"id": "27655845",
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"url": "https://glygen.org/publication/PubMed/27655845"
},
{
"id": "21300897",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/21300897"
},
{
"id": "35132862",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/35132862"
},
{
"id": "29351928",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29351928"
}
]
},
{
"glytoucan_ac": "",
"type": "N-linked",
"subtype": "",
"site_category": "reported",
"site_seq": "N",
"relation": "attached",
"comment": "N-linked (GlcNAc...) asparagine",
"start_pos": 199,
"start_aa": "Asn",
"end_pos": 199,
"end_aa": "Asn",
"residue": "Asn",
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"evidence": [
{
"id": "P08575",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08575#ptm_processing"
},
{
"id": "24190977",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/24190977"
},
{
"id": "GLY_000143",
"database": "GlyGen",
"url": "https://data.glygen.org/GLY_000143"
}
]
},
{
"glytoucan_ac": "G06356OH",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 234,
"start_aa": "Asn",
"end_pos": 234,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn234",
"evidence": [
{
"id": "339",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/339"
},
{
"id": "29391424",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29391424"
}
]
},
{
"glytoucan_ac": "G13694XX",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 234,
"start_aa": "Asn",
"end_pos": 234,
"end_aa": "Asn",
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{
"name": "positive regulation of stem cell proliferation",
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],
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{
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],
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{
"name": "negative regulation of microglial cell activation",
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{
"name": "regulation of receptor signaling pathway via JAK-STAT",
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],
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{
"name": "positive regulation of humoral immune response mediated by circulating immunoglobulin",
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{
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],
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{
"name": "cell surface receptor signaling pathway",
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{
"name": "response to gamma radiation",
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{
"name": "positive regulation of MAPK cascade",
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],
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{
"name": "defense response to virus",
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],
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{
"name": "positive regulation of ERK1 and ERK2 cascade",
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{
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{
"name": "negative regulation of protein kinase activity",
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],
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},
{
"name": "cellular response to extracellular stimulus",
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],
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{
"name": "T cell activation",
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],
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{
"name": "positive regulation of protein kinase activity",
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],
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},
{
"name": "T cell receptor signaling pathway",
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],
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{
"name": "positive regulation of B cell proliferation",
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],
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},
{
"name": "leukocyte cell-cell adhesion",
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],
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{
"name": "positive regulation of peptidyl-tyrosine phosphorylation",
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{
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{
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{
"name": "release of sequestered calcium ion into cytosol",
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{
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{
"name": "positive regulation of extrinsic apoptotic signaling pathway",
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{
"name": "positive regulation of T cell mediated cytotoxicity",
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{
"name": "B cell differentiation",
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{
"name": "positive regulation of tumor necrosis factor production",
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{
"name": "protein dephosphorylation",
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{
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{
"name": "regulation of gene expression",
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{
"name": "negative regulation of protein autophosphorylation",
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],
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{
"name": "positive regulation of T cell proliferation",
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],
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{
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{
"name": "calcium-mediated signaling using intracellular calcium source",
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],
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{
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],
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{
"name": "positive regulation of interleukin-2 production",
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],
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{
"name": "positive regulation of isotype switching to IgG isotypes",
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],
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},
{
"name": "DN2 thymocyte differentiation",
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],
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{
"name": "negative regulation of T cell mediated cytotoxicity",
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],
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},
{
"name": "response to aldosterone",
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],
"pmid": ""
},
{
"name": "positive regulation of gamma-delta T cell differentiation",
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],
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{
"name": "positive regulation of protein tyrosine phosphatase activity",
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],
"pmid": ""
},
{
"name": "bone marrow development",
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],
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},
{
"name": "T cell differentiation",
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],
"pmid": ""
},
{
"name": "cell cycle phase transition",
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],
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{
"name": "positive thymic T cell selection",
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],
"pmid": ""
},
{
"name": "regulation of interleukin-8 production",
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],
"pmid": ""
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{
"name": "plasma membrane raft distribution",
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],
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{
"name": "negative regulation of cell adhesion involved in substrate-bound cell migration",
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],
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{
"name": "B cell proliferation",
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],
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},
{
"name": "regulation of cell cycle",
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],
"pmid": ""
},
{
"name": "positive regulation of alpha-beta T cell proliferation",
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],
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},
{
"name": "heterotypic cell-cell adhesion",
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],
"pmid": ""
},
{
"name": "gamma-delta T cell differentiation",
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],
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},
{
"name": "stem cell development",
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],
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{
"name": "positive regulation of Fc receptor mediated stimulatory signaling pathway",
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],
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},
{
"name": "positive regulation of hematopoietic stem cell migration",
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],
"pmid": ""
},
{
"name": "positive regulation of immunoglobulin production",
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],
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{
"name": "regulation of phagocytosis",
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],
"pmid": ""
},
{
"name": "regulation of protein tyrosine kinase activity",
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],
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}
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},
{
"name": "Molecular Function",
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],
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},
{
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],
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{
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"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "heparan sulfate proteoglycan binding",
"id": "GO:0043395",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043395",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "spectrin binding",
"id": "GO:0030507",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030507",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "ankyrin binding",
"id": "GO:0030506",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "transmembrane receptor protein tyrosine phosphatase activity",
"id": "GO:0005001",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005001",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "protein tyrosine phosphatase activity",
"id": "GO:0004725",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 11,
"go_terms": [
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "focal adhesion",
"id": "GO:0005925",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "cell surface",
"id": "GO:0009986",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "membrane",
"id": "GO:0016020",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "membrane raft",
"id": "GO:0045121",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "extracellular exosome",
"id": "GO:0070062",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "external side of plasma membrane",
"id": "GO:0009897",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "secretory granule membrane",
"id": "GO:0030667",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030667",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "cytoplasmic side of plasma membrane",
"id": "GO:0009898",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "bleb",
"id": "GO:0032059",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032059",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
},
{
"name": "membrane microdomain",
"id": "GO:0098857",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098857",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [
{
"name": "receptor-type tyrosine-protein phosphatase C O-glycosylated 1 (human)",
"definition": "A receptor-type tyrosine-protein phosphatase C (human) that has been O-glycosylated at the residue equivalent to Ser-176 of the amino acid sequence represented by UniProtKB:P08575-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08575-3, Ser-176, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000054484",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000054484"
}
]
},
{
"name": "receptor-type tyrosine-protein phosphatase C O-glycosylated 2 (human)",
"definition": "A receptor-type tyrosine-protein phosphatase C (human) that has been O-glycosylated at the residue equivalent to Thr-167 of the amino acid sequence represented by UniProtKB:P08575-3, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P08575-3, Thr-167, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000054485",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000054485"
}
]
},
{
"name": "receptor-type tyrosine-protein phosphatase C O-glycosylated 3 (human)",
"definition": "A receptor-type tyrosine-protein phosphatase C (human) that has been O-glycosylated at the residue equivalent to Thr-167 of the amino acid sequence represented by UniProtKB:P08575-3, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P08575-3, Thr-167, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000054486",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000054486"
}
]
}
],
"site_annotation": [
{
"start_pos": 1019,
"end_pos": 1021,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 1124,
"end_pos": 1126,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 1152,
"end_pos": 1154,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 186,
"end_pos": 188,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 192,
"end_pos": 194,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 199,
"end_pos": 201,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 234,
"end_pos": 236,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 262,
"end_pos": 264,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 272,
"end_pos": 274,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 278,
"end_pos": 280,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 337,
"end_pos": 339,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 380,
"end_pos": 382,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 421,
"end_pos": 423,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 470,
"end_pos": 472,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 490,
"end_pos": 492,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 531,
"end_pos": 533,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 709,
"end_pos": 711,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 80,
"end_pos": 82,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 921,
"end_pos": 923,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 92,
"end_pos": 94,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 968,
"end_pos": 970,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 97,
"end_pos": 99,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Heavily N- and O-glycosylated.",
"evidence": [
{
"database": "UniProtKB",
"id": "P08575",
"url": "https://www.uniprot.org/uniprot/P08575"
},
{
"database": "PubMed",
"id": "19349973",
"url": "https://glygen.org/publication/PubMed/19349973"
},
{
"database": "PubMed",
"id": "19159218",
"url": "https://glygen.org/publication/PubMed/19159218"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "10684",
"name": "",
"equation": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q6P9X4-1",
"O08617-1",
"Q5FVI9-1",
"B4F7B7-1",
"Q03348-1",
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"O54838-1",
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"P41498-1",
"P41499-2",
"P49445-1",
"A1L1L3-1",
"Q64612-1",
"A0A8I5ZV35-1",
"A0A0G2K3H0-1",
"A0A0G2K2N0-1",
"F1LP13-1",
"A0A0G2K1T5-1",
"A0A8I5ZN56-1",
"A0A8I6A1V1-1",
"Q5PQT2-1",
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"A0A0G2JZ01-1",
"A0A8I6B402-1",
"A0A0G2K9N1-1",
"D3ZVI5-1",
"A0A8I6GK94-1",
"F1LQQ5-1",
"G3V6B9-1",
"Q2YDV1-1",
"G3V7Q4-1",
"A0A8I5ZW41-1",
"G3V9S3-1",
"D3ZNK9-1",
"D4ADT2-1",
"D4A3W6-1",
"D3ZBG7-1",
"P20646-1",
"A0A8I6G7Q4-1",
"A6HQ12-1",
"A0A8I6AJQ7-1",
"A0A8I6B5G4-1",
"A0A8I5Y1B8-1",
"Q9UMZ3-1",
"P18031-1",
"Q99502-1",
"O75061-1",
"Q9UNH5-1",
"A4D256-1",
"O60729-1",
"Q16667-1",
"P51452-1",
"Q9BV47-1",
"Q99504-1",
"O95677-1",
"Q9H596-1",
"O00167-1",
"Q6B8I1-1",
"Q9NRW4-1",
"Q16828-1",
"Q4G0W2-1",
"Q99956-1",
"Q8NEJ0-1",
"O95147-1",
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"Q9BVJ7-1",
"Q9H1R2-1",
"Q9UII6-1",
"Q16690-1",
"Q13115-1",
"Q9UNI6-1",
"Q9BY84-1",
"Q9Y6W6-1",
"Q05923-1",
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"Q68J44-1",
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"Q8WTR2-1",
"Q13202-1",
"P30307-1",
"P30304-1",
"Q86V88-1",
"P30305-1",
"Q9NYA4-1",
"Q13615-1",
"Q15678-1",
"Q9Y2R2-1",
"Q15256-1",
"Q16827-1",
"Q06124-2",
"Q15262-1",
"Q4JDL3-1",
"P54829-1",
"O14522-3",
"P28827-1",
"P35236-1",
"Q99952-1",
"P29350-1",
"Q12913-1",
"P23467-1",
"P08575-3",
"P18433-5",
"Q9HD43-1",
"P23470-1",
"Q92932-1",
"A6NDG6-1",
"Q8WUK0-1",
"P43378-1",
"P23468-1",
"Q16825-1",
"Q9H3S7-1",
"P29074-1",
"P17706-1",
"P26045-1",
"P10586-1",
"Q92729-1",
"P24666-1",
"P23469-1",
"Q12923-1",
"P23471-1",
"Q13332-1",
"Q05209-1",
"P60484-1",
"P56180-1",
"O75365-1",
"Q76I76-1",
"Q12974-1",
"Q8TE77-1",
"Q93096-1",
"Q8TF42-1",
"Q8WYL5-1",
"P15309-1",
"Q63HR2-1",
"Q9Z191-1",
"P97767-1",
"Q80TZ3-1",
"Q810P3-1",
"Q6GQT0-1",
"Q6PFY9-1",
"Q99N11-1",
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"Q9QYJ7-1",
"Q8R4V2-1",
"Q8VE01-1",
"Q91Z46-1",
"O09112-1",
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"Q8K4T5-1",
"Q6NT99-1",
"O08575-1",
"Q8BK84-1",
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"Q9WUA5-1",
"Q9JLY7-1",
"Q05922-1",
"Q9D0T2-1",
"Q9D700-1",
"Q9D7X3-1",
"Q9D9D8-1",
"Q9ESS0-1",
"P97480-1",
"Q9D967-1",
"P48967-1",
"P30306-1",
"P48964-1",
"Q91XS1-1",
"Q8K296-1",
"Q8CHP8-1",
"Q9D358-1",
"P54830-1",
"Q62132-1",
"Q64487-4",
"O70274-1",
"Q9D658-1",
"P29352-1",
"Q62130-1",
"Q63739-1",
"P28828-1",
"P29351-1",
"Q9WU22-1",
"Q8K330-1",
"Q62136-1",
"A2A8L5-1",
"B0V2N1-1",
"B2RU80-1",
"B9EKR1-1",
"E9Q0N2-1",
"E9Q612-1",
"B1AUH1-1",
"O35239-1",
"P35831-1",
"P49446-1",
"P35821-1",
"P35822-1",
"Q8BUM3-1",
"Q8BGG7-1",
"A2ALK8-1",
"O55082-1",
"P18052-1",
"Q6PB44-1",
"Q64512-1",
"P06800-4",
"P0C5E4-1",
"P35235-2",
"P80560-1",
"Q05909-1",
"Q06180-1",
"Q61152-1",
"Q5SW75-1",
"Q64455-1",
"Q66GT5-1",
"Q76I79-1",
"Q99M80-1",
"P70289-1",
"O08586-1",
"Q7TNL7-1",
"Q1HL35-1",
"Q8CE08-1",
"Q8CGB6-1",
"P25044-1",
"Q00684-1",
"P29461-1",
"P23748-1",
"P38148-1",
"P50946-1",
"P38590-1",
"P40048-1",
"P40347-1",
"P40479-1",
"Q02256-1",
"P40081-1",
"Q12454-1",
"Q54T76-1",
"Q1ZXG8-1",
"Q54DU9-1",
"Q54R42-1",
"Q55BI8-1",
"Q55CS8-1",
"Q55E39-1",
"Q55GW2-1",
"Q86IL4-1",
"P34137-1",
"P34138-1",
"P54637-1",
"Q54QM6-1",
"Q54Y32-1",
"Q556Y8-1",
"Q55CS7-1",
"Q8T9S7-1",
"P82890-1",
"P35832-1",
"P29349-1",
"P35992-5",
"Q6NN85-1",
"Q86BN8-1",
"Q7KMQ6-1",
"P82891-1",
"A1ZAB3-1",
"P16621-1",
"O61722-1",
"Q9W0G1-1",
"Q03019-1",
"P20483-1",
"X2JEB8-1",
"Q9VVW5-1",
"Q05201-1",
"P16620-1",
"Q9VWF4-1",
"Q9W4F5-1",
"Q9W0R3-1"
],
"evidence": [
{
"id": "10684",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/10684"
}
]
},
{
"id": "R-HSA-202214",
"name": "Dephosphorylation of Lck-pY505 by CD45",
"equation": "",
"summary": "TCR stimulation induce the transient dephosphorylation of PAG thereby release the Csk from its plasma membrane anchor. The release of Csk from its proximity with Lck may serve to facilitate the activation of Lck.Protein tyrosine phosphtase CD45 (PTPRC) and CD148 (PTPRJ) have dual function in TCR signalling. They act both in activation as well as inactivation of Src family kinases (SFKs) which are involved in the initiation of TCR signal transduction (Stepanek et al. 2011). The activatory role is to dephosphorylate an inhibitory site tyrosine 505 (Y505) at the C-terminal end of Lck, which is needed to enable Lck to an open conformation and expose the activation loop (A-loop) containing the activating tyrosine 394 (Y394) (Xu et al. 1993. McNeill et al. 2007, Zikherman et al. 2010, Stepanek et al. 2011, Salmond et al. 2009).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08575-3",
"P06239-1",
"Q12913-1"
],
"evidence": [
{
"id": "R-HSA-202214",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202214"
}
]
},
{
"id": "R-HSA-202233",
"name": "Inactivation of Lck by Csk",
"equation": "",
"summary": "Lck is a member of the Src family tyrosine kinases and these members have the following domains in common: N-terminal Myristoylation site for saturated fatty acid addition, a unique region, a Src-homology 3 (SH3) domain, an SH2 domain, a tyrosine kinase domain (SH1), and a C-terminal negative regulatory domain. Myristoylation engenders Lck with the ability to attach to cellular membranes. This interaction is mediated by both myristic acid and palmitic acid that are bound to the amino terminal glycine and Cys-3 and/or Cys-5.
The unique region of Lck is thought to be involved in the interaction with the cytoplasmic tails of coreceptors CD4 and CD8. The Lck/CD4 interaction require conserved cysteine motifs: a CxCP motif in CD4 and a CxxC motif in the Lck unique domain. The SH3 and SH2 domains of Lck are involved in intramolecular and intermolecular regulation by mediating protein-protein interactions via poly-proline and phosphotyrosine-specific interactions, respectively.
Lck adopts specific conformation that largely dictate its level of activity. The C-ter tail has an autoinhibitory phosphorylation site (tyr 505). When the Y505 is phosphorylated, Lck adopts a closed conformation, where the pY505 residue creates an intramolecular binding motif for the SH2 domain, effectively inactivating the kinase domain. The inactivating phosphorylation on Y505 is carried out by the Src-specific kinase Csk.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08575-3",
"P41240-1",
"P06239-1",
"Q12913-1"
],
"evidence": [
{
"id": "R-HSA-202233",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202233"
}
]
},
{
"id": "R-HSA-373746",
"name": "SEMA4D interacts with CD45",
"equation": "",
"summary": "SEMA4D also associates with CD45, a cell surface protein tyrosine phosphatase (PTP) considered a key molecule in the T-cell receptor (TCR) activation process.",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08575-3"
],
"evidence": [
{
"id": "R-HSA-373746",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373746"
}
]
},
{
"id": "R-HSA-6798743",
"name": "Exocytosis of secretory granule membrane proteins",
"equation": "",
"summary": "Secretory vesicles provide a reservoir of membrane-associated receptors that are required at the earliest stages of the neutrophil-mediated inflammatory response. They are mobilized in response to a wide variety of inflammatory stimuli (Sengelov et al. 1993a,b). Resultant cell surface changes allow the neutrophil to establish firm contact with activated vascular epithelium (Faurschou & Borregaard 2003).",
"cellular_location": "plasma membrane, secretory granule membrane",
"input_participant_list": [],
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"enzyme_list": [
"P08575-3",
"Q86UQ4-1",
"P63000-1",
"P43353-1",
"P15144-1",
"P61586-1",
"P61018-1",
"P61020-1",
"P15291-1",
"P08473-1",
"P61026-1",
"P51149-1"
],
"evidence": [
{
"id": "R-HSA-6798743",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798743"
}
]
}
],
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{
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{
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}
]
}
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},
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}
]
},
{
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]
}
]
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}
]
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{
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]
}
]
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}
]
},
{
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"id": "A0A0G2K3H0",
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]
}
]
},
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]
},
{
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}
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}
]
},
{
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},
{
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},
{
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},
{
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"id": "A0A8I5Y1B8",
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]
}
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]
},
{
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]
}
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}
]
},
{
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{
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}
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]
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{
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]
}
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{
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{
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]
},
{
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]
}
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{
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"id": "A0A8I6AJQ7",
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]
},
{
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"id": "A0A8I6AJQ7",
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]
}
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]
},
{
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}
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},
{
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{
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{
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]
},
{
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{
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]
}
]
},
{
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{
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"id": "A0A8I6G7Q4",
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}
]
},
{
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{
"id": "A0A8I6G7Q4",
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}
]
},
{
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"evidence": [
{
"id": "A0A8I6G7Q4",
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}
]
},
{
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{
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]
}
]
},
{
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{
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]
},
{
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]
}
]
},
{
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{
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}
]
},
{
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"id": "A1L1L3",
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}
]
}
]
},
{
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{
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"id": "A1ZAB3",
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]
},
{
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]
}
]
},
{
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{
"ec_number": "3.1.3.48",
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{
"id": "A2A8L5",
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}
]
},
{
"ec_number": "3.1.3.48",
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]
}
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},
{
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]
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{
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]
}
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]
},
{
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]
},
{
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]
},
{
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}
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},
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]
},
{
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{
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}
]
},
{
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{
"id": "A6HQ12",
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]
},
{
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"id": "A6HQ12",
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]
}
]
},
{
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{
"ec_number": "3.1.3.21",
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"id": "A6NDG6",
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]
},
{
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{
"id": "A6NDG6",
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]
},
{
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"id": "A6NDG6",
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]
}
]
},
{
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"url": "https://www.uniprot.org/uniprot/O09112"
}
]
}
]
},
{
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"gene_name": "PTPRT",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O14522",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14522"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O14522",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14522"
}
]
}
]
},
{
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{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O35239",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35239"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O35239",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35239"
}
]
}
]
},
{
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{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
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{
"id": "O54838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54838"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O54838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54838"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O54838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54838"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "O54838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54838"
}
]
}
]
},
{
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{
"ec_number": "3.1.3.67",
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{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
},
{
"ec_number": "3.1.3.48",
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"evidence": [
{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
},
{
"ec_number": "3.1.3.67",
"activity": "",
"evidence": [
{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
},
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "O54857",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54857"
}
]
}
]
},
{
"uniprot_ac": "O55082",
"gene_name": "Ptpn20",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O55082",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55082"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O55082",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55082"
}
]
}
]
},
{
"uniprot_ac": "O60729",
"gene_name": "CDC14B",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "O60729",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60729"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O60729",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60729"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O60729",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60729"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "O60729",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60729"
}
]
}
]
},
{
"uniprot_ac": "O61722",
"gene_name": "PRL-1",
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{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O61722",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61722"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O61722",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61722"
}
]
}
]
},
{
"uniprot_ac": "O70274",
"gene_name": "Ptp4a2",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O70274",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70274"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O70274",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70274"
}
]
}
]
},
{
"uniprot_ac": "O75061",
"gene_name": "DNAJC6",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O75061",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75061"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O75061",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75061"
}
]
}
]
},
{
"uniprot_ac": "O75365",
"gene_name": "PTP4A3",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O75365",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75365"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O75365",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75365"
}
]
}
]
},
{
"uniprot_ac": "O88488",
"gene_name": "Ptprq",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O88488",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88488"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O88488",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88488"
}
]
},
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "O88488",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88488"
}
]
}
]
},
{
"uniprot_ac": "O88902",
"gene_name": "Ptpn23",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O88902",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88902"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O88902",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88902"
}
]
}
]
},
{
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"gene_name": "DUSP14",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "O95147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95147"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O95147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95147"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "O95147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95147"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O95147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95147"
}
]
}
]
},
{
"uniprot_ac": "O95677",
"gene_name": "EYA4",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O95677",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95677"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O95677",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95677"
}
]
}
]
},
{
"uniprot_ac": "P04157",
"gene_name": "Ptprc",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P04157",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04157"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P04157",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04157"
}
]
}
]
},
{
"uniprot_ac": "P06239",
"gene_name": "LCK",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P06239",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06239"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P06239",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06239"
}
]
}
]
},
{
"uniprot_ac": "P06800",
"gene_name": "Ptprc",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P06800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06800"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P06800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06800"
}
]
}
]
},
{
"uniprot_ac": "P08473",
"gene_name": "MME",
"activity": [
{
"ec_number": "3.4.24.11",
"activity": "Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.",
"evidence": [
{
"id": "P08473",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08473"
}
]
},
{
"ec_number": "3.4.24.11",
"activity": "",
"evidence": [
{
"id": "P08473",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08473"
}
]
}
]
},
{
"uniprot_ac": "P08575",
"gene_name": "PTPRC",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P08575",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08575"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P08575",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08575"
}
]
}
]
},
{
"uniprot_ac": "P0C089",
"gene_name": "Ptpmt1",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P0C089",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C089"
}
]
},
{
"ec_number": "3.1.3.27",
"activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.",
"evidence": [
{
"id": "P0C089",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C089"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P0C089",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C089"
}
]
},
{
"ec_number": "3.1.3.27",
"activity": "",
"evidence": [
{
"id": "P0C089",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C089"
}
]
}
]
},
{
"uniprot_ac": "P0C595",
"gene_name": "Dusp29",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P0C595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C595"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P0C595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C595"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P0C595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C595"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P0C595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C595"
}
]
}
]
},
{
"uniprot_ac": "P0C5E4",
"gene_name": "Ptprq",
"activity": [
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "P0C5E4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C5E4"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P0C5E4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C5E4"
}
]
}
]
},
{
"uniprot_ac": "P10586",
"gene_name": "PTPRF",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P10586",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10586"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P10586",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10586"
}
]
}
]
},
{
"uniprot_ac": "P15144",
"gene_name": "ANPEP",
"activity": [
{
"ec_number": "3.4.11.2",
"activity": "Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.",
"evidence": [
{
"id": "P15144",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15144"
}
]
},
{
"ec_number": "3.4.11.2",
"activity": "",
"evidence": [
{
"id": "P15144",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15144"
}
]
}
]
},
{
"uniprot_ac": "P15291",
"gene_name": "B4GALT1",
"activity": [
{
"ec_number": "2.4.1.-",
"activity": "",
"evidence": [
{
"id": "P15291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15291"
}
]
},
{
"ec_number": "2.4.1.275",
"activity": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP.",
"evidence": [
{
"id": "P15291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15291"
}
]
},
{
"ec_number": "2.4.1.22",
"activity": "D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP.",
"evidence": [
{
"id": "P15291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15291"
}
]
},
{
"ec_number": "2.4.1.38",
"activity": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
"evidence": [
{
"id": "P15291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15291"
}
]
},
{
"ec_number": "2.4.1.90",
"activity": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP.",
"evidence": [
{
"id": "P15291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15291"
}
]
}
]
},
{
"uniprot_ac": "P15309",
"gene_name": "ACP3",
"activity": [
{
"ec_number": "3.1.3.5",
"activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.",
"evidence": [
{
"id": "P15309",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15309"
}
]
},
{
"ec_number": "3.1.3.2",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "P15309",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15309"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P15309",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15309"
}
]
},
{
"ec_number": "3.1.3.2",
"activity": "",
"evidence": [
{
"id": "P15309",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15309"
}
]
}
]
},
{
"uniprot_ac": "P16620",
"gene_name": "Ptp69D",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P16620",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16620"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P16620",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16620"
}
]
}
]
},
{
"uniprot_ac": "P16621",
"gene_name": "Lar",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P16621",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16621"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P16621",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16621"
}
]
}
]
},
{
"uniprot_ac": "P17706",
"gene_name": "PTPN2",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P17706",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17706"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P17706",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17706"
}
]
}
]
},
{
"uniprot_ac": "P18031",
"gene_name": "PTPN1",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P18031",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18031"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P18031",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18031"
}
]
}
]
},
{
"uniprot_ac": "P18052",
"gene_name": "Ptpra",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P18052",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18052"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P18052",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18052"
}
]
}
]
},
{
"uniprot_ac": "P18433",
"gene_name": "PTPRA",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P18433",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18433"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P18433",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18433"
}
]
}
]
},
{
"uniprot_ac": "P20417",
"gene_name": "Ptpn1",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P20417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20417"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P20417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20417"
}
]
}
]
},
{
"uniprot_ac": "P20483",
"gene_name": "stg",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P20483",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20483"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P20483",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20483"
}
]
}
]
},
{
"uniprot_ac": "P20646",
"gene_name": "Acp3",
"activity": [
{
"ec_number": "3.1.3.2",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "P20646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20646"
}
]
},
{
"ec_number": "3.1.3.2",
"activity": "",
"evidence": [
{
"id": "P20646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20646"
}
]
},
{
"ec_number": "3.1.3.5",
"activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.",
"evidence": [
{
"id": "P20646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20646"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P20646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20646"
}
]
}
]
},
{
"uniprot_ac": "P23467",
"gene_name": "PTPRB",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P23467",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23467"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P23467",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23467"
}
]
}
]
},
{
"uniprot_ac": "P23468",
"gene_name": "PTPRD",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P23468",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23468"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P23468",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23468"
}
]
}
]
},
{
"uniprot_ac": "P23469",
"gene_name": "PTPRE",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P23469",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23469"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P23469",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23469"
}
]
}
]
},
{
"uniprot_ac": "P23470",
"gene_name": "PTPRG",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P23470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23470"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P23470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23470"
}
]
}
]
},
{
"uniprot_ac": "P23471",
"gene_name": "PTPRZ1",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P23471",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23471"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P23471",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23471"
}
]
}
]
},
{
"uniprot_ac": "P23748",
"gene_name": "MIH1",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P23748",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23748"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P23748",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23748"
}
]
}
]
},
{
"uniprot_ac": "P24666",
"gene_name": "ACP1",
"activity": [
{
"ec_number": "3.1.3.2",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "P24666",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24666"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P24666",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24666"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P24666",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24666"
}
]
}
]
},
{
"uniprot_ac": "P25044",
"gene_name": "PTP1",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P25044",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25044"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P25044",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25044"
}
]
}
]
},
{
"uniprot_ac": "P26045",
"gene_name": "PTPN3",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P26045",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26045"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P26045",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26045"
}
]
}
]
},
{
"uniprot_ac": "P28562",
"gene_name": "DUSP1",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P28562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28562"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P28562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28562"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P28562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28562"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P28562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28562"
}
]
}
]
},
{
"uniprot_ac": "P28563",
"gene_name": "Dusp1",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P28563",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28563"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P28563",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28563"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P28563",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28563"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P28563",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28563"
}
]
}
]
},
{
"uniprot_ac": "P28827",
"gene_name": "PTPRM",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P28827",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28827"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P28827",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28827"
}
]
}
]
},
{
"uniprot_ac": "P28828",
"gene_name": "Ptprm",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P28828",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28828"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P28828",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28828"
}
]
}
]
},
{
"uniprot_ac": "P29074",
"gene_name": "PTPN4",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P29074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29074"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P29074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29074"
}
]
}
]
},
{
"uniprot_ac": "P29349",
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"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P29349",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29349"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P29349",
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}
]
}
]
},
{
"uniprot_ac": "P29350",
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"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
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{
"id": "P29350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29350"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P29350",
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"url": "https://www.uniprot.org/uniprot/P29350"
}
]
}
]
},
{
"uniprot_ac": "P29351",
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"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P29351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29351"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "P29351",
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"url": "https://www.uniprot.org/uniprot/P29351"
}
]
}
]
},
{
"uniprot_ac": "P29352",
"gene_name": "Ptpn22",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "P29352",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29352"
}
]
},
{
"ec_number": "3.1.3.48",
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{
"id": "P29352",
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"url": "https://www.uniprot.org/uniprot/P29352"
}
]
}
]
},
{
"uniprot_ac": "P29461",
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"activity": [
{
"ec_number": "3.1.3.48",
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{
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}
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},
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}
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}
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}
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}
]
}
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}
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}
]
}
]
},
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}
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},
{
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}
]
}
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},
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}
]
},
{
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]
}
]
},
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]
},
{
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]
}
]
},
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]
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{
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]
},
{
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}
]
},
{
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}
]
}
]
},
{
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}
]
},
{
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}
]
},
{
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]
},
{
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]
}
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},
{
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}
]
},
{
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}
]
},
{
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}
]
},
{
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}
]
}
]
},
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]
},
{
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]
},
{
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}
]
},
{
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{
"id": "Q556Y8",
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}
]
}
]
},
{
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"ec_number": "3.1.3.16",
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}
]
},
{
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{
"id": "Q55BI8",
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}
]
},
{
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}
]
},
{
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{
"id": "Q55BI8",
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}
]
}
]
},
{
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{
"ec_number": "3.1.3.16",
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}
]
},
{
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{
"id": "Q55CS7",
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}
]
},
{
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}
]
},
{
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{
"id": "Q55CS7",
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}
]
}
]
},
{
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{
"ec_number": "3.1.3.16",
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{
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}
]
},
{
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{
"id": "Q55CS8",
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}
]
},
{
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{
"id": "Q55CS8",
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}
]
},
{
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{
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]
}
]
},
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{
"ec_number": "3.1.3.16",
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{
"id": "Q55E39",
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]
},
{
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{
"id": "Q55E39",
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]
},
{
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{
"id": "Q55E39",
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}
]
},
{
"ec_number": "3.1.3.16",
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{
"id": "Q55E39",
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]
}
]
},
{
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{
"ec_number": "3.1.3.2",
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{
"id": "Q55GW2",
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}
]
},
{
"ec_number": "3.1.3.48",
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{
"id": "Q55GW2",
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]
},
{
"ec_number": "3.1.3.48",
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{
"id": "Q55GW2",
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]
}
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},
{
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"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
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{
"id": "Q5FVI9",
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}
]
},
{
"ec_number": "3.1.3.48",
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{
"id": "Q5FVI9",
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}
]
},
{
"ec_number": "3.1.3.16",
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{
"id": "Q5FVI9",
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}
]
},
{
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{
"id": "Q5FVI9",
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]
}
]
},
{
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"id": "Q5PQT2",
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}
]
},
{
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{
"id": "Q5PQT2",
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]
},
{
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"id": "Q5PQT2",
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}
]
},
{
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{
"id": "Q5PQT2",
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}
]
},
{
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{
"id": "Q5PQT2",
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}
]
}
]
},
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"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
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{
"id": "Q5SW75",
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}
]
},
{
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{
"id": "Q5SW75",
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}
]
},
{
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{
"id": "Q5SW75",
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}
]
},
{
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{
"id": "Q5SW75",
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]
}
]
},
{
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"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
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{
"id": "Q5XIS1",
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}
]
},
{
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}
]
},
{
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{
"id": "Q5XIS1",
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"url": "https://www.uniprot.org/uniprot/Q5XIS1"
}
]
},
{
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{
"id": "Q5XIS1",
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}
]
}
]
},
{
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{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
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{
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}
]
},
{
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}
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}
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{
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}
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}
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}
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]
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{
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{
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]
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]
},
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}
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{
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},
{
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]
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{
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]
}
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{
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{
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},
{
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}
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]
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{
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]
},
{
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{
"id": "Q86BN8",
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]
},
{
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{
"id": "Q86BN8",
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]
}
]
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]
},
{
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{
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{
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]
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{
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{
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]
},
{
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{
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]
},
{
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{
"id": "Q86V88",
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]
}
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},
{
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]
},
{
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{
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]
},
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]
}
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},
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]
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},
{
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]
},
{
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]
},
{
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]
}
]
},
{
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{
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]
},
{
"ec_number": "3.1.3.48",
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{
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]
},
{
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{
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]
},
{
"ec_number": "3.1.3.48",
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{
"id": "Q8BTR5",
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]
}
]
},
{
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{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
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{
"id": "Q8BUM3",
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]
},
{
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]
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]
},
{
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{
"ec_number": "3.1.3.5",
"activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.",
"evidence": [
{
"id": "Q8CE08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CE08"
}
]
},
{
"ec_number": "3.1.3.2",
"activity": "a phosphate monoester + H2O = an alcohol + phosphate.",
"evidence": [
{
"id": "Q8CE08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CE08"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8CE08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CE08"
}
]
},
{
"ec_number": "3.1.3.2",
"activity": "",
"evidence": [
{
"id": "Q8CE08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CE08"
}
]
}
]
},
{
"uniprot_ac": "Q8CGB6",
"gene_name": "Tns2",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8CGB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGB6"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8CGB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGB6"
}
]
}
]
},
{
"uniprot_ac": "Q8CHP8",
"gene_name": "Pgp",
"activity": [
{
"ec_number": "3.1.3.21",
"activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.",
"evidence": [
{
"id": "Q8CHP8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CHP8"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8CHP8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CHP8"
}
]
},
{
"ec_number": "3.1.3.21",
"activity": "",
"evidence": [
{
"id": "Q8CHP8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CHP8"
}
]
}
]
},
{
"uniprot_ac": "Q8K296",
"gene_name": "Mtmr3",
"activity": [
{
"ec_number": "3.1.3.64",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.",
"evidence": [
{
"id": "Q8K296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K296"
}
]
},
{
"ec_number": "3.1.3.64",
"activity": "",
"evidence": [
{
"id": "Q8K296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K296"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8K296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K296"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8K296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K296"
}
]
},
{
"ec_number": "3.1.3.95",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.",
"evidence": [
{
"id": "Q8K296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K296"
}
]
}
]
},
{
"uniprot_ac": "Q8K330",
"gene_name": "Ssh3",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8K330",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K330"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8K330",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K330"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8K330",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K330"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8K330",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K330"
}
]
}
]
},
{
"uniprot_ac": "Q8K4T5",
"gene_name": "Dusp19",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8K4T5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4T5"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8K4T5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4T5"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8K4T5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4T5"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8K4T5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4T5"
}
]
}
]
},
{
"uniprot_ac": "Q8NEJ0",
"gene_name": "DUSP18",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8NEJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEJ0"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8NEJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEJ0"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8NEJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEJ0"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8NEJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEJ0"
}
]
}
]
},
{
"uniprot_ac": "Q8R4V2",
"gene_name": "Dusp15",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8R4V2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4V2"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8R4V2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4V2"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8R4V2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4V2"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8R4V2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4V2"
}
]
}
]
},
{
"uniprot_ac": "Q8T9S7",
"gene_name": "pteN",
"activity": [
{
"ec_number": "3.1.3.67",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
},
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
},
{
"ec_number": "3.1.3.67",
"activity": "",
"evidence": [
{
"id": "Q8T9S7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9S7"
}
]
}
]
},
{
"uniprot_ac": "Q8TE77",
"gene_name": "SSH3",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8TE77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TE77"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8TE77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TE77"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8TE77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TE77"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8TE77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TE77"
}
]
}
]
},
{
"uniprot_ac": "Q8TF42",
"gene_name": "UBASH3B",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8TF42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TF42"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8TF42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TF42"
}
]
}
]
},
{
"uniprot_ac": "Q8VE01",
"gene_name": "Dusp18",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8VE01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VE01"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8VE01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VE01"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8VE01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VE01"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8VE01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VE01"
}
]
}
]
},
{
"uniprot_ac": "Q8WTR2",
"gene_name": "DUSP19",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8WTR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WTR2"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8WTR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WTR2"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8WTR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WTR2"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8WTR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WTR2"
}
]
}
]
},
{
"uniprot_ac": "Q8WUK0",
"gene_name": "PTPMT1",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8WUK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WUK0"
}
]
},
{
"ec_number": "3.1.3.27",
"activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.",
"evidence": [
{
"id": "Q8WUK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WUK0"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8WUK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WUK0"
}
]
},
{
"ec_number": "3.1.3.27",
"activity": "",
"evidence": [
{
"id": "Q8WUK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WUK0"
}
]
}
]
},
{
"uniprot_ac": "Q8WYL5",
"gene_name": "SSH1",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8WYL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WYL5"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q8WYL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WYL5"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q8WYL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WYL5"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q8WYL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WYL5"
}
]
}
]
},
{
"uniprot_ac": "Q91XQ2",
"gene_name": "Epm2a",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q91XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XQ2"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q91XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XQ2"
}
]
},
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "Q91XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XQ2"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q91XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XQ2"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "Q91XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XQ2"
}
]
}
]
},
{
"uniprot_ac": "Q91XS1",
"gene_name": "Mtmr4",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q91XS1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XS1"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q91XS1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XS1"
}
]
}
]
},
{
"uniprot_ac": "Q91Z46",
"gene_name": "Dusp7",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q91Z46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91Z46"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q91Z46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91Z46"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
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