{ "uniprot_canonical_ac": "P08519-1", "uniprot_ac": "P08519", "uniprot_id": "APOA_HUMAN", "mass": { "chemical_mass": 226546.0, "monoisotopic_mass": 226546.0 }, "refseq": { "ac": "NP_005568", "name": "apolipoprotein(a) precursor", "summary": "The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" }, "gene_names": [ { "name": "LPA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08519", "id": "P08519" }, { "name": "AK38; APOA; LP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568", "id": "NP_005568" }, { "name": "LPA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568", "id": "NP_005568" } ], "protein_names": [ { "name": "Apolipoprotein(a)", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08519" }, { "name": "3.4.21.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08519" }, { "name": "Apo(a)", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08519" }, { "name": "Lp(a)", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08519" }, { "name": "antiangiogenic AK38 protein; apolipoprotein(a); lp(a); apo(a); lipoprotein, Lp(a)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568", "id": "NP_005568" }, { "name": "apolipoprotein(a) precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568", "id": "NP_005568" } ], "function": [ { "annotation": "Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519#function" }, { "database": "PubMed", "id": "2531657", "url": "https://glygen.org/publication/PubMed/2531657" } ] }, { "annotation": "Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis.", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" }, { "database": "PubMed", "id": "38057070", "url": "https://glygen.org/publication/PubMed/38057070" } ] }, { "annotation": "Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" }, { "database": "PubMed", "id": "38098866", "url": "https://glygen.org/publication/PubMed/38098866" } ] }, { "annotation": "Association of the LPA gene polymorphisms with coronary artery disease risk in the Xinjiang population of China: A case-control study.", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" }, { "database": "PubMed", "id": "38050271", "url": "https://glygen.org/publication/PubMed/38050271" } ] }, { "annotation": "Lipoprotein(a) and Risks of Peripheral Artery Disease, Abdominal Aortic Aneurysm, and Major Adverse Limb Events.", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" }, { "database": "PubMed", "id": "38057068", "url": "https://glygen.org/publication/PubMed/38057068" } ] }, { "annotation": "The association of lipoprotein (a) with coronary artery calcification: A systematic review and meta-analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" }, { "database": "PubMed", "id": "38101270", "url": "https://glygen.org/publication/PubMed/38101270" } ] }, { "annotation": "The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs777394889", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777394889" }, { "id": "rs777394889", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777394889" }, { "id": "rs777394889", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs777394889" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 1013, "end_pos": 1013, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->KLT).", "chr_id": "6", "chr_pos": "160601005", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N1013", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1027477900", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1027477900" }, { "id": "rs1027477900", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1027477900#frequency_tab" }, { "id": "rs1027477900", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1027477900" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 1015, "end_pos": 1015, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NLI).", "chr_id": "6", "chr_pos": "160601000", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1015", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1027477900", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1027477900" }, { "id": "rs1027477900", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1027477900#frequency_tab" }, { "id": "rs1027477900", "database": 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"alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1031", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs749220823", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749220823" }, { "id": "rs749220823", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749220823" }, { "id": "rs749220823", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs749220823#frequency_tab" }, { "id": "rs749220823", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs749220823" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 1127, "end_pos": 1127, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->KLT).", "chr_id": "6", "chr_pos": "160595442", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N1127", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": 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"name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", 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"length": 2040, "header": "sp|P08519-1|APOA_HUMAN Isoform 1 of Apolipoprotein(a) OS=Homo sapiens OX=9606 GN=LPA PE=1 SV=2 CANONICAL=P08519-1" }, "isoforms": [ { "isoform_ac": "P08519-1", "url": "", "sequence": { "sequence": "MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN", "length": 2040, "header": "sp|P08519-1|APOA_HUMAN Isoform 1 of Apolipoprotein(a) OS=Homo sapiens OX=9606 GN=LPA PE=1 SV=2 CANONICAL=P08519-1" }, "locus": { "chromosome": "6", "start_pos": 160664214, "end_pos": 160531732, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000316300.10", "url": "https://www.ensembl.org/id/ENST00000316300.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000321334.6", "url": "https://www.ensembl.org/id/ENSP00000321334.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1013, "start_aa": "Asn", "end_pos": 1013, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1013", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 101, "start_aa": "Asn", "end_pos": 101, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn101", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1127, "start_aa": "Asn", "end_pos": 1127, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1127", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1241, "start_aa": "Asn", "end_pos": 1241, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1241", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1347, "start_aa": "Asn", "end_pos": 1347, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1347", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1381, "start_aa": "Asn", "end_pos": 1381, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1381", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1461, "start_aa": "Asn", "end_pos": 1461, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1461", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1575, "start_aa": "Asn", "end_pos": 1575, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1575", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1689, "start_aa": "Asn", "end_pos": 1689, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1689", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "G27391WQ", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 16, "start_aa": "Ser", "end_pos": 16, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser16", "evidence": [ { "id": "P08519", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 16, "start_aa": "Ser", "end_pos": 16, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser16", "evidence": [ { "id": "P08519", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 16, "start_aa": "Ser", "end_pos": 16, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser16", "evidence": [ { "id": "P08519", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G11629QQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 183, "start_aa": "Asn", "end_pos": 183, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn183", "evidence": [ { "id": "56", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/56" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G13694XX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 183, "start_aa": "Asn", "end_pos": 183, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn183", "evidence": [ { "id": "56", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/56" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G37881RL", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 183, "start_aa": "Asn", "end_pos": 183, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn183", "evidence": [ { "id": "56", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/56" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 215, "start_aa": "Asn", "end_pos": 215, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn215", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 329, "start_aa": "Asn", "end_pos": 329, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn329", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 443, "start_aa": "Asn", "end_pos": 443, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn443", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-PRORULE", "url": "https://prosite.expasy.org/rule/PRU00498" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 557, "start_aa": "Asn", "end_pos": 557, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn557", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": 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it.", "journal": "The EMBO journal", "date": "1989-12-20", "authors": "Salonen E M, Jauhiainen M, Zardi L, Vaheri A, Ehnholm C", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "reference": [ { "type": "PubMed", "id": "2531657", "url": "https://glygen.org/publication/PubMed/2531657" } ] }, { "title": "Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "Swenson TL, Brocia RW, Tall AR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041" } ], "reference": [ { "type": "PubMed", "id": "2833496", "url": "https://glygen.org/publication/PubMed/2833496" } ] }, { "title": "Large-scale intact glycopeptide identification by Mascot database search.", "journal": "Scientific reports", "date": "2018", "authors": "Bollineni RC, Koehler CJ, Gislefoss RE, Anonsen JH, Thiede B", "evidence": [ { "database": "GlyConnect", "id": "56", "url": "https://glyconnect.expasy.org/browser/proteins/56" } ], "reference": [ { "type": "PubMed", "id": "29391424", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "date": "2018", "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "P08519", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "title": "cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.", "journal": "Nature", "date": "1987", "authors": "McLean J W, Tomlinson J E, Kuang W J, Eaton D L, Chen E Y, Fless G M, Scanu A M, Lawn R M", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "reference": [ { "type": "PubMed", "id": "3670400", "url": "https://glygen.org/publication/PubMed/3670400" } ] }, { "title": "Association of the LPA gene polymorphisms with coronary artery disease risk in the Xinjiang population of China: A case-control study.", "journal": "Medicine", "date": "2023-12-01", "authors": "Liu Yi-Wen, Dong Chun-Lan, Jiang Xue, Liu Deng-Yao", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" } ], "reference": [ { "type": "PubMed", "id": "38050271", "url": "https://glygen.org/publication/PubMed/38050271" } ] }, { "title": "Lipoprotein(a) and Risks of Peripheral Artery Disease, Abdominal Aortic Aneurysm, and Major Adverse Limb\u00a0Events.", "journal": "Journal of the American College of Cardiology", "date": "2023-12-12", "authors": "Thomas Peter E, Vedel-Krogh Signe, Nielsen Sune F, Nordestgaard B\u00f8rge G, Kamstrup Pia R", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" } ], "reference": [ { "type": "PubMed", "id": "38057068", "url": "https://glygen.org/publication/PubMed/38057068" } ] }, { "title": "Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis.", "journal": "Journal of the American College of Cardiology", "date": "2023-12-12", "authors": "Chehab Omar, Abdollahi Ashkan, Whelton Seamus P, Wu Colin O, Ambale-Venkatesh Bharath, Post Wendy S, Bluemke David A, Tsai Michael Y, Lima Jo\u00e3o A C", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" } ], "reference": [ { "type": "PubMed", "id": "38057070", "url": "https://glygen.org/publication/PubMed/38057070" } ] }, { "title": "Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study.", "journal": "Frontiers in endocrinology", "date": "2023", "authors": "Yan Xuejiao, Gong Jing, Wang Zhenwei, Wang Fangfang, Qi Chunjian", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" } ], "reference": [ { "type": "PubMed", "id": "38098866", "url": "https://glygen.org/publication/PubMed/38098866" } ] }, { "title": "The association of lipoprotein (a) with coronary artery calcification: A systematic review and meta-analysis.", "journal": "Atherosclerosis", "date": "2024-01", "authors": "Qiu Yuyao, Hao Wen, Guo Yingying, Guo Qian, Zhang Yushi, Liu Xiaochen, Wang Xiao, Nie Shaoping", "evidence": [ { "database": "RefSeq", "id": "NP_005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005568" } ], "reference": [ { "type": "PubMed", "id": "38101270", "url": "https://glygen.org/publication/PubMed/38101270" } ] }, { "title": "Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma.", "journal": "The Journal of biological chemistry", "date": "1983", "authors": "Morton RE, Zilversmit DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041" } ], "reference": [ { "type": "PubMed", "id": "6619141", "url": "https://glygen.org/publication/PubMed/6619141" } ] }, { "title": "Amplification of human APO(a) kringle 4-37 from blood lymphocyte DNA.", "journal": "Biochim. Biophys. Acta", "date": "1993", "authors": "Pfaffinger D, Mc Lean J, Scanu A M", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "reference": [ { "type": "PubMed", "id": "7848387", "url": "https://glygen.org/publication/PubMed/7848387" } ] }, { "title": "A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a).", "journal": "Biochimica et biophysica acta", "date": "1994", "authors": "Scanu AM, Pfaffinger D, Lee JC, Hinman J", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "reference": [ { "type": "PubMed", "id": "7918682", "url": "https://glygen.org/publication/PubMed/7918682" } ] }, { "title": "Crystal structures of apolipoprotein(a) kringle IV37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: existence of novel and expected binding modes.", "journal": "J. Mol. Biol.", "date": "1996", "authors": "Mikol V, LoGrasso P V, Boettcher B R", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "reference": [ { "type": "PubMed", "id": "8642595", "url": "https://glygen.org/publication/PubMed/8642595" } ] }, { "title": "Intracellular metabolism of human apolipoprotein(a) in stably transfected Hep G2 cells.", "journal": "Biochemistry", "date": "1998", "authors": "Lobentanz EM, Krasznai K, Gruber A, Brunner C, Muller HJ, Sattler J, Kraft HG, Utermann G, Dieplinger H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041" } ], "reference": [ { "type": "PubMed", "id": "9548923", "url": "https://glygen.org/publication/PubMed/9548923" } ] }, { "title": "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Wang X, Driscoll DM, Morton RE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041" } ], "reference": [ { "type": "PubMed", "id": "9880564", "url": "https://glygen.org/publication/PubMed/9880564" } ] } ], "pathway": [ { "id": "hsa:4018", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4018", "resource": "KEGG Pathway" }, { "id": "R-HSA-8964041", "name": "LDL remodeling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964041", "resource": "Reactome", "description": "LDL remodeling" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "endopeptidase activity", "id": "GO:0004175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "apolipoprotein binding", "id": "GO:0034185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034185", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "endopeptidase inhibitor activity", "id": "GO:0004866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004866", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "fibronectin binding", "id": "GO:0001968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001968", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "plasma lipoprotein particle", "id": "GO:0034358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034358", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" }, { "name": "blood circulation", "id": "GO:0008015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008015", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "apolipoprotein(a) O-glycosylated 1 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-16 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G27391WQ. Example: UniProtKB:P08519-1, Ser-16, MOD:00002~GNO:G27391WQ. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054451", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054451" } ] }, { "name": "apolipoprotein(a) O-glycosylated 2 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-16 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Ser-16, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054452", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054452" } ] }, { "name": "apolipoprotein(a) O-glycosylated 3 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-16 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Ser-16, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054453", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054453" } ] }, { "name": "apolipoprotein(a) O-glycosylated 4 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-3320 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Ser-3320, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054454", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054454" } ] }, { "name": "apolipoprotein(a) O-glycosylated 5 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-3670 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Ser-3670, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054455", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054455" } ] }, { "name": "apolipoprotein(a) O-glycosylated 6 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-3768 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G27391WQ. Example: UniProtKB:P08519-1, Ser-3768, MOD:00002~GNO:G27391WQ. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054456", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054456" } ] }, { "name": "apolipoprotein(a) O-glycosylated 7 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-3768 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Ser-3768, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054457", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054457" } ] }, { "name": "apolipoprotein(a) O-glycosylated 8 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-3776 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Ser-3776, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054458", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054458" } ] }, { "name": "apolipoprotein(a) O-glycosylated 9 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Ser-4219 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Ser-4219, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054459", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054459" } ] }, { "name": "apolipoprotein(a) O-glycosylated 10 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3325 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Thr-3325, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054460", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054460" } ] }, { "name": "apolipoprotein(a) O-glycosylated 11 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3325 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3325, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054461", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054461" } ] }, { "name": "apolipoprotein(a) O-glycosylated 12 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3439 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3439, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054462", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054462" } ] }, { "name": "apolipoprotein(a) O-glycosylated 13 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3553 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Thr-3553, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054463", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054463" } ] }, { "name": "apolipoprotein(a) O-glycosylated 14 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3553 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3553, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054464", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054464" } ] }, { "name": "apolipoprotein(a) O-glycosylated 15 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3556 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3556, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054465", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054465" } ] }, { "name": "apolipoprotein(a) O-glycosylated 16 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3667 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Thr-3667, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054466", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054466" } ] }, { "name": "apolipoprotein(a) O-glycosylated 17 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3667 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3667, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054467", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054467" } ] }, { "name": "apolipoprotein(a) O-glycosylated 18 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3765 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Thr-3765, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054468", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054468" } ] }, { "name": "apolipoprotein(a) O-glycosylated 19 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3773 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G27391WQ. Example: UniProtKB:P08519-1, Thr-3773, MOD:00005~GNO:G27391WQ. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054469", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054469" } ] }, { "name": "apolipoprotein(a) O-glycosylated 20 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3773 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Thr-3773, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054470", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054470" } ] }, { "name": "apolipoprotein(a) O-glycosylated 21 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3773 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3773, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054471", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054471" } ] }, { "name": "apolipoprotein(a) O-glycosylated 22 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3887 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3887, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054472", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054472" } ] }, { "name": "apolipoprotein(a) O-glycosylated 23 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-3891 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-3891, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054473", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054473" } ] }, { "name": "apolipoprotein(a) O-glycosylated 24 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-4115 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P08519-1, Thr-4115, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054474", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054474" } ] }, { "name": "apolipoprotein(a) O-glycosylated 25 (human)", "definition": "An apolipoprotein(a) (human) that has been O-glycosylated at the residue equivalent to Thr-4115 of the amino acid sequence represented by UniProtKB:P08519-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08519-1, Thr-4115, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054475", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054475" } ] } ], "site_annotation": [ { "start_pos": 1013, "end_pos": 1015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1127, "end_pos": 1129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1241, "end_pos": 1243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1347, "end_pos": 1349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1381, "end_pos": 1383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1461, "end_pos": 1463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1575, "end_pos": 1577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1689, "end_pos": 1691, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 671, "end_pos": 673, "annotation": "n_glycosylation_sequon" }, { "start_pos": 785, "end_pos": 787, "annotation": "n_glycosylation_sequon" }, { "start_pos": 899, "end_pos": 901, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.", "evidence": [ { "database": "UniProtKB", "id": "P08519", "url": "https://www.uniprot.org/uniprot/P08519" }, { "database": "PubMed", "id": "11294842", "url": "https://glygen.org/publication/PubMed/11294842" } ] } ], "interactions": [], "reactions": [ { "id": "R-HSA-176879", "name": "apolipoprotein(a) + LDL => Lp(a)", "equation": "", "summary": "As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle. Although LPA is synthesized in liver cells, LPA - LDL binding appears to occur primarily extracellularly in vivo, on the hepatocyte surface or in the blood (Lobentanz et al. 1998). Lp(a) particles are relatively long-lived, with a half-life in human plasma of three to four days (Krempler et al. 1980), and the molecular mechanism of their clearance from the blood in vivo remains obscure. Lp(a) particles are of clinical interest because elevated levels of them are correlated with elevated risk of coronary heart disease (reviewed by Marcovina et al. 2003).", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08519-1" ], "evidence": [ { "id": "R-HSA-176879", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-176879" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P08519", "gene_name": "LPA", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "P08519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08519" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 61, 75, 101, 183, 215, 329, 443, 557, 671, 785, 899, 1013, 1127, 1241, 1347, 1381, 1461, 1575, 1689 ], "o_linked_sites": [ 16 ], "snv_sites": [ 40, 61, 63, 299, 305, 329, 331, 345, 403, 787, 859, 869, 899, 900, 1013, 1015, 1031, 1127, 1211, 1243, 1349, 1383, 1461, 1542, 1577, 1689, 1691, 1726, 1737, 1909 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1013, "end_pos": 1015 }, { "start_pos": 101, "end_pos": 103 }, { "start_pos": 1127, "end_pos": 1129 }, { "start_pos": 1241, "end_pos": 1243 }, { "start_pos": 1347, "end_pos": 1349 }, { "start_pos": 1381, "end_pos": 1383 }, { "start_pos": 1461, "end_pos": 1463 }, { "start_pos": 1575, "end_pos": 1577 }, { "start_pos": 1689, "end_pos": 1691 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 557, "end_pos": 559 }, { "start_pos": 61, "end_pos": 63 }, { "start_pos": 671, "end_pos": 673 }, { "start_pos": 785, "end_pos": 787 }, { "start_pos": 899, "end_pos": 901 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 41 }, { "field": "total_sites", "count": 21 }, { "field": "n_linked_glycans", "count": 12 }, { "field": "n_linked_glycan_sites", "count": 19 }, { "field": "o_linked_glycans", "count": 10 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 17 }, { "field": "total_sites", "count": 17 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 17 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 24 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 12 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 10 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 40 }, { "field": "total_sites", "count": 30 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 40 }, { "field": "total_sites", "count": 30 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }