{ "uniprot_canonical_ac": "P08319-1", "uniprot_ac": "P08319", "uniprot_id": "ADH4_HUMAN", "mass": { "chemical_mass": 40222.0, "monoisotopic_mass": 40222.0 }, "refseq": { "ac": "NP_000661", "name": "all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 2", "summary": "This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661" }, "gene_names": [ { "name": "ADH4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08319", "id": "P08319" }, { "name": "ADH-2; HEL-S-4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661", "id": "NP_000661" }, { "name": "ADH2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P08319", "id": "P08319" }, { "name": "ADH4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661", "id": "NP_000661" } ], "protein_names": [ { "name": "All-trans-retinol dehydrogenase [NAD(+)] ADH4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08319" }, { "name": "1.1.1.105", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08319" }, { "name": "Alcohol dehydrogenase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08319" }, { "name": "Alcohol dehydrogenase 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08319" }, { "name": "Alcohol dehydrogenase class II pi chain", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08319" }, { "name": "aldehyde reductase; alcohol dehydrogenase class II pi chain; epididymis secretory protein Li 4; all-trans-retinol dehydrogenase [NAD(+)] ADH4; alcohol dehydrogenase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661", "id": "NP_000661" }, { "name": "all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661", "id": "NP_000661" } ], "function": [ { "annotation": "A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells.", "evidence": [ { "database": "RefSeq", "id": "NP_000661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661" }, { "database": "PubMed", "id": "33556337", "url": "https://glygen.org/publication/PubMed/33556337" } ] }, { "annotation": "Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.", "evidence": [ { "database": "RefSeq", "id": "NP_000661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661" }, { "database": "PubMed", "id": "31768945", "url": "https://glygen.org/publication/PubMed/31768945" } ] }, { "annotation": "Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444).", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319#function" }, { "database": "PubMed", "id": "10514444", "url": "https://glygen.org/publication/PubMed/10514444" }, { "database": "PubMed", "id": "17279314", "url": "https://glygen.org/publication/PubMed/17279314" }, { "database": "PubMed", "id": "16081420", "url": "https://glygen.org/publication/PubMed/16081420" } ] }, { "annotation": "No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta-analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_000661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661" }, { "database": "PubMed", "id": "35437765", "url": "https://glygen.org/publication/PubMed/35437765" } ] }, { "annotation": "Novel Insights into MEG3/miR664a-3p/ADH4 Axis and Its Possible Role in Hepatocellular Carcinoma from an in Silico Perspective. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661" }, { "database": "PubMed", "id": "36553522", "url": "https://glygen.org/publication/PubMed/36553522" } ] }, { "annotation": "This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_000661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000661" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "67.25", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "82.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "45.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "87.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "64.71", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "62.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "58.29", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "97.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "56.79", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "73.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198099", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198099" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P08319", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08319" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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isoform of Alcohol dehydrogenase 4 (class II), pi polypeptide OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=1 CANONICAL=P08319-1" }, "locus": { "chromosome": "4", "start_pos": 99143240, "end_pos": 99131633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000512499.5", "url": "https://www.ensembl.org/id/ENST00000512499.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000423571.1", "url": "https://www.ensembl.org/id/ENSP00000423571.1" } ] } }, { "isoform_ac": "D6RF43-1", "url": "", "sequence": { "sequence": "MLVRGPHFELQRCKTHLFSSNYLTQREKLETLYQGY", "length": 36, "header": "tr|D6RF43-1|ADH4_HUMAN Computationally mapped isoform of All-trans-retinol dehydrogenase [NAD(+)] ADH4 OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=1 CANONICAL=P08319-1" }, "locus": { "chromosome": "4", "start_pos": 99143240, "end_pos": 99142776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000504894.1", "url": "https://www.ensembl.org/id/ENST00000504894.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000427261.1", "url": "https://www.ensembl.org/id/ENSP00000427261.1" } ] } }, { "isoform_ac": "D6RIB1-1", "url": "", "sequence": { "sequence": "MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKIRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASR", "length": 206, "header": "tr|D6RIB1-1|D6RIB1_HUMAN Computationally mapped isoform of Alcohol dehydrogenase 4 (class II), pi polypeptide OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=1 CANONICAL=P08319-1" }, "locus": { "chromosome": "4", "start_pos": 99144222, "end_pos": 99131675, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000504125.1", "url": "https://www.ensembl.org/id/ENST00000504125.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000427525.1", "url": "https://www.ensembl.org/id/ENSP00000427525.1" } ] } }, { "isoform_ac": "H0Y9N0-1", "url": "", "sequence": { "sequence": "NLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMVGKV", "length": 115, "header": "tr|H0Y9N0-1|ADH4_HUMAN Computationally mapped isoform of All-trans-retinol dehydrogenase [NAD(+)] ADH4 OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=1 CANONICAL=P08319-1" }, "locus": { "chromosome": "4", "start_pos": 99136537, "end_pos": 99126721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000509471.5", "url": "https://www.ensembl.org/id/ENST00000509471.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000424583.1", "url": "https://www.ensembl.org/id/ENSP00000424583.1" } ] } }, { "isoform_ac": "P08319-1", "url": "", "sequence": { "sequence": "MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF", "length": 380, "header": "sp|P08319-1|ADH4_HUMAN Isoform 1 of All-trans-retinol dehydrogenase [NAD(+)] ADH4 OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=5 CANONICAL=P08319-1" }, "locus": { "chromosome": "4", "start_pos": 99144222, "end_pos": 99124445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000265512.12", "url": "https://www.ensembl.org/id/ENST00000265512.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000265512.7", "url": "https://www.ensembl.org/id/ENSP00000265512.7" } ] } }, { "isoform_ac": "P08319-2", "url": "", "sequence": { "sequence": "MLVRGPHFELQRCKTHLFSSNYLTQVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF", "length": 399, "header": "sp|P08319-2|ADH4_HUMAN Isoform 2 of All-trans-retinol dehydrogenase [NAD(+)] ADH4 OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=5 CANONICAL=P08319-1" }, "locus": { "chromosome": "4", "start_pos": 99143240, "end_pos": 99124445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000508393.5", "url": "https://www.ensembl.org/id/ENST00000508393.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000424630.1", "url": "https://www.ensembl.org/id/ENSP00000424630.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P08319", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08319" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "phosphorylation": [ { "start_pos": 121, "end_pos": 121, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P08319", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08319" } ], "site_lbl": "Ser121" }, { "start_pos": 278, "end_pos": 278, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P08319", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08319" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser278" }, { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P08319", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08319" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Thr280" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes.", "journal": "Molecular genetics and metabolism", "date": "1999", "authors": "Jurukovski V, Markova NG, Karaman-Jurukovska N, Randolph RK, Su J, Napoli JL, Simon M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "10329026", "url": "https://glygen.org/publication/PubMed/10329026" } ] }, { "title": "Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus.", "journal": "Nature genetics", "date": "1999", "authors": "Yamamoto H, Simon A, Eriksson U, Harris E, Berson EL, Dryja TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "10369264", "url": "https://glygen.org/publication/PubMed/10369264" } ] }, { "title": "Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.", "journal": "American journal of human genetics", "date": "1999", "authors": "Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10441588", "url": "https://glygen.org/publication/PubMed/10441588" } ] }, { "title": "A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Svensson S, Stromberg P, Hoog JO", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "reference": [ { "type": "PubMed", "id": "10514444", "url": "https://glygen.org/publication/PubMed/10514444" } ] }, { "title": "Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.", "journal": "Protein science : a publication of the Protein Society", "date": "1999", "authors": "Ni L, Zhou J, Hurley TD, Weiner H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10631996", "url": "https://glygen.org/publication/PubMed/10631996" } ] }, { "title": "Regulation of the mammalian alcohol dehydrogenase genes.", "journal": "Progress in nucleic acid research and molecular biology", "date": "2000", "authors": "Edenberg HJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10697413", "url": "https://glygen.org/publication/PubMed/10697413" } ] }, { "title": "Retinoid-binding proteins: mediators of retinoid action.", "journal": "The Biochemical journal", "date": "2000", "authors": "Noy N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "10839978", "url": "https://glygen.org/publication/PubMed/10839978" } ] }, { "title": "Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Luong A, Hannah VC, Brown MS, Goldstein JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10843999", "url": "https://glygen.org/publication/PubMed/10843999" } ] }, { "title": "cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Lin M, Napoli JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "11007799", "url": "https://glygen.org/publication/PubMed/11007799" } ] }, { "title": "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium.", "journal": "Cancer research", "date": "2001", "authors": "Lin B, White JT, Ferguson C, Wang S, Vessella R, Bumgarner R, True LD, Hood L, Nelson PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "11245473", "url": "https://glygen.org/publication/PubMed/11245473" } ] }, { "title": "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "12036956", "url": "https://glygen.org/publication/PubMed/12036956" } ] }, { "title": "Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "12226107", "url": "https://glygen.org/publication/PubMed/12226107" } ] }, { "title": "Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate.", "journal": "Biochemistry", "date": "2003", "authors": "Lei Z, Chen W, Zhang M, Napoli JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "12680773", "url": "https://glygen.org/publication/PubMed/12680773" } ] }, { "title": "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, Amad M, Korczak B, Petkovich M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "14532297", "url": "https://glygen.org/publication/PubMed/14532297" } ] }, { "title": "Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene.", "journal": "FEBS letters", "date": "2003", "authors": "Picozzi P, Marozzi A, Fornasari D, Benfante R, Barisani D, Meneveri R, Ginelli E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "14596915", "url": "https://glygen.org/publication/PubMed/14596915" } ] }, { "title": "Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Collins XH, Harmon SD, Kaduce TL, Berst KB, Fang X, Moore SA, Raju TV, Falck JR, Weintraub NL, Duester G, Plapp BV, Spector AA", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "reference": [ { "type": "PubMed", "id": "16081420", "url": "https://glygen.org/publication/PubMed/16081420" } ] }, { "title": "Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "16788062", "url": "https://glygen.org/publication/PubMed/16788062" } ] }, { "title": "Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2007", "authors": "Hellgren M, Stromberg P, Gallego O, Martras S, Farres J, Persson B, Pares X, Hoog JO", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "reference": [ { "type": "PubMed", "id": "17279314", "url": "https://glygen.org/publication/PubMed/17279314" } ] }, { "title": "Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene.", "journal": "Biochemical and biophysical research communications", "date": "1991", "authors": "Chen CS, Yoshida A", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "1755855", "url": "https://glygen.org/publication/PubMed/1755855" } ] }, { "title": "Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.", "journal": "The FEBS journal", "date": "2008", "authors": "Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "18039331", "url": "https://glygen.org/publication/PubMed/18039331" } ] }, { "title": "Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.", "journal": "Biochimica et biophysica acta", "date": "1977", "authors": "Greenfield NJ, Pietruszko R", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "18196", "url": "https://glygen.org/publication/PubMed/18196" } ] }, { "title": "Retinoic acid synthesis and signaling during early organogenesis.", "journal": "Cell", "date": "2008", "authors": "Duester G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "18805086", "url": "https://glygen.org/publication/PubMed/18805086" } ] }, { "title": "Cloning and characterization of the human ADH4 gene.", "journal": "Gene", "date": "1991", "authors": "von Bahr-Lindstrom H, Jornvall H, Hoog JO", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" }, { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "1889753", "url": "https://glygen.org/publication/PubMed/1889753" } ] }, { "title": "Purification and characterization of a new alcohol dehydrogenase from human stomach.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Moreno A, Pares X", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "1985938", "url": "https://glygen.org/publication/PubMed/1985938" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, 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"https://www.ebi.ac.uk/QuickGO/term/GO:0044281", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 13, "go_terms": [ { "name": "alcohol dehydrogenase (NAD+) activity", "id": "GO:0004022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004022", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "S-(hydroxymethyl)glutathione dehydrogenase activity", "id": "GO:0051903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051903", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "NADPH:quinone reductase activity", "id": "GO:0003960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003960", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "alcohol dehydrogenase activity, zinc-dependent", "id": "GO:0004024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004024", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "alditol:NADP+ 1-oxidoreductase activity", "id": "GO:0004032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "NAD-retinol dehydrogenase activity", "id": "GO:0004745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004745", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "all-trans retinal binding", "id": "GO:0005503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005503", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "id": "GO:0016620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016620", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "benzaldehyde dehydrogenase [NAD(P)+] activity", "id": "GO:0019115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019115", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "retinol binding", "id": "GO:0019841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019841", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P08319", "url": "https://www.uniprot.org/uniprot/P08319" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21284", "name": "", "equation": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "Q64563-1", "Q8VD48-1", "P41682-1", "P50170-1", "O54753-1", "D3ZGP9-1", "P08319-1", "P40394-1", "P00325-1", "Q9BPW9-1", "O75452-1", "Q7Z5P4-1", "O14756-1", "A6NNS2-1", "Q64437-1", "Q9QYY9-1", "Q58NB6-1", "Q9R092-1", "Q8VCR2-1", "Q8CHS7-1" ], "evidence": [ { "id": "21284", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21284" } ] }, { "id": "39799", "name": "", "equation": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P12711-1", "Q64563-1", "P08319-1", "P11766-1", "P28474-1", "Q9QYY9-1" ], "evidence": [ { "id": "39799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39799" } ] }, { "id": "39803", "name": "", "equation": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64563-1", "P12711-1", "P08319-1", "P11766-1", "P28474-1", "Q9QYY9-1" ], "evidence": [ { "id": "39803", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39803" } ] }, { "id": "42052", "name": "", "equation": "9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64563-1", "P41682-1", "P50170-1", "P08319-1", "P40394-1", "Q92781-1", "O75452-1", "Q64437-1", "Q9QYY9-1", "O55240-1", "O54909-1" ], "evidence": [ { "id": "42052", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42052" } ] }, { "id": "60660", "name": "", "equation": "1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64563-1", "P08319-1", "Q9QYY9-1" ], "evidence": [ { "id": "60660", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60660" } ] }, { "id": "R-HSA-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "equation": "", "summary": "Some alcohol dehydrogenases (ADHs) utilise NAD+ as cofactor to reversibly oxidise all-trans-retinol (atROL) to all-trans-retinal (atRAL), a retinoid aldehyde, in vitro (von Bahr-Lindstrom et al. 1986, Ikuta et al. 1986, von Bahr-Lindstrom et al. 1991, Xie et al. 1997). ADH1A (ADH1) and ADH4 have high activity and ADH1C (ADH3) has low activity with non-physiological amounts of retinol in vitro. ADH1A and ADH1C metabolize toxic amounts of retinol in vivo, but ADH4 does not. Physiological contributions of ADHs to retinol metabolism have not been demonstrated, in contrast to RDHs.;", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08319-1", "P00326-1", "P07327-1" ], "evidence": [ { "id": "R-HSA-5362564", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5362564" } ] }, { "id": "R-HSA-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "equation": "", "summary": "Cytosolic alcohol dehydrogenase catalyzes the reaction of ethanol and NAD+ to form acetaldehyde and NADH + H+. The active form of the enzyme is a dimer with one zinc ion bound to each protein subunit. In the body, alcohol dehydrogenase is present in the liver, kidney, lung and gastric mucosa.

Six genes encode proteins active in ethanol oxidation: ADH1A, ADH1B, ADH1C, ADH4, ADH6, and ADH7 (Lange et al. 1976; Yin et al. 1985; Li et al. 1978; Bosron et al. 1979; Moreno and Pares 1991; Yokoyama et al. 1994; Chen and Yoshida 1991). ADH1A, B and C proteins can associate to form homodimers or heterodimers; ADH4, 6, and 7 proteins each form homodimers. Expression of ADH1A, B and C is developmentally regulated: ADH1A protein is abundant in the fetus, but expressed only at low levels in adulthood, when ADH1B and C proteins are abundant (Edenberg 2000). The various dimers differ substantially in the efficiency with which they oxidize ethanol. The ADH1B homodimer and heterodimers containing at least one 1B monomer are the most active towards ethanol (Yin et al. 1985). In addition, common polymorphic variants of ADH1B and C proteins differ substantially in this respect (Murray and Price 1972).", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-30203" ], "output_participant_list": [], "enzyme_list": [ "P08319-1", "P40394-1", "P00325-1", "P00326-1", "P07327-1", "P28332-1" ], "evidence": [ { "id": "R-HSA-71707", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71707" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-30203", "participant_name": "EtOH [cytosol]", "crossref": [ { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A6NNS2", "gene_name": "DHRS7C", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "A6NNS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNS2" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "A6NNS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNS2" } ] } ] }, { "uniprot_ac": "D3ZGP9", "gene_name": "Dhrs7c", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "D3ZGP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGP9" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "D3ZGP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGP9" } ] } ] }, { "uniprot_ac": "O14756", "gene_name": "HSD17B6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] } ] }, { "uniprot_ac": "O54753", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] } ] }, { "uniprot_ac": "O54909", "gene_name": "Rdh16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54909" } ] } ] }, { "uniprot_ac": "O55240", "gene_name": "Rdh5", "activity": [ { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O55240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55240" } ] } ] }, { "uniprot_ac": "O75452", "gene_name": "RDH16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] } ] }, { "uniprot_ac": "P00325", "gene_name": "ADH1B", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P00325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00325" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P00325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00325" } ] } ] }, { "uniprot_ac": "P00326", "gene_name": "ADH1C", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P00326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00326" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P00326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00326" } ] } ] }, { "uniprot_ac": "P07327", "gene_name": "ADH1A", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P07327", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07327" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P07327", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07327" } ] } ] }, { "uniprot_ac": "P08319", "gene_name": "ADH4", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P08319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08319" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P08319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08319" } ] } ] }, { "uniprot_ac": "P11766", "gene_name": "ADH5", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P11766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11766" } ] }, { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P11766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11766" } ] }, { "ec_number": "1.1.1.284", "activity": "NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione.", "evidence": [ { "id": "P11766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11766" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P11766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11766" } ] } ] }, { "uniprot_ac": "P12711", "gene_name": "Adh5", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P12711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12711" } ] }, { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P12711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12711" } ] }, { "ec_number": "1.1.1.284", "activity": "NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione.", "evidence": [ { "id": "P12711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12711" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P12711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12711" } ] }, { "ec_number": "1.1.1.284", "activity": "", "evidence": [ { "id": "P12711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12711" } ] } ] }, { "uniprot_ac": "P28332", "gene_name": "ADH6", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P28332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28332" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P28332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28332" } ] } ] }, { "uniprot_ac": "P28474", "gene_name": "Adh5", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P28474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28474" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P28474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28474" } ] }, { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P28474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28474" } ] }, { "ec_number": "1.1.1.284", "activity": "NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione.", "evidence": [ { "id": "P28474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28474" } ] } ] }, { "uniprot_ac": "P40394", "gene_name": "ADH7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] } ] }, { "uniprot_ac": "P41682", "gene_name": "Adh7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] } ] }, { "uniprot_ac": "P50170", "gene_name": "Rdh16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] } ] }, { "uniprot_ac": "Q58NB6", "gene_name": "Dhrs9", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] } ] }, { "uniprot_ac": "Q5M875", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] } ] }, { "uniprot_ac": "Q64437", "gene_name": "Adh7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] } ] }, { "uniprot_ac": "Q64563", "gene_name": "Adh4", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q64563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64563" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q64563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64563" } ] } ] }, { "uniprot_ac": "Q7Z5P4", "gene_name": "HSD17B13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] } ] }, { "uniprot_ac": "Q8CHS7", "gene_name": "Dhrs7c", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8CHS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHS7" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q8CHS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHS7" } ] } ] }, { "uniprot_ac": "Q8VCR2", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] } ] }, { "uniprot_ac": "Q8VD48", "gene_name": "Dhrs9", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD48" } ] }, { "ec_number": 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