{ "uniprot_canonical_ac": "P08172-1", "uniprot_ac": "P08172", "uniprot_id": "ACM2_HUMAN", "mass": { "chemical_mass": 51715.0, "monoisotopic_mass": 51715.0 }, "refseq": { "ac": "NP_000730", "name": "muscarinic acetylcholine receptor M2", "summary": "The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730" }, "gene_names": [ { "name": "CHRM2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08172", "id": "P08172" }, { "name": "CHRM2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730", "id": "NP_000730" }, { "name": "HM2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730", "id": "NP_000730" } ], "protein_names": [ { "name": "Muscarinic acetylcholine receptor M2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08172" }, { "name": "muscarinic M2 receptor; 7TM receptor; acetylcholine receptor, muscarinic 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730", "id": "NP_000730" }, { "name": "muscarinic acetylcholine receptor M2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730", "id": "NP_000730" } ], "function": [ { "annotation": "Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics.", "evidence": [ { "database": "RefSeq", "id": "NP_000730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730" }, { "database": "PubMed", "id": "34390568", "url": "https://glygen.org/publication/PubMed/34390568" } ] }, { "annotation": "Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_000730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730" }, { "database": "PubMed", "id": "32234387", "url": "https://glygen.org/publication/PubMed/32234387" } ] }, { "annotation": "M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730" }, { "database": "PubMed", "id": "34359896", "url": "https://glygen.org/publication/PubMed/34359896" } ] }, { "annotation": "The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.", "evidence": [ { "database": "UniProtKB", "id": "P08172", "url": "https://www.uniprot.org/uniprot/P08172#function" }, { "database": "PubMed", "id": "24256733", "url": "https://glygen.org/publication/PubMed/24256733" }, { "database": "PubMed", "id": "3443095", "url": "https://glygen.org/publication/PubMed/3443095" } ] }, { "annotation": "The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_000730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000730" } ] }, { "annotation": "Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R). 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"MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P08172", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08172" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08172" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR", "length": 466, "header": "sp|P08172-1|ACM2_HUMAN Isoform 1 of Muscarinic acetylcholine receptor M2 OS=Homo sapiens OX=9606 GN=CHRM2 PE=1 SV=1 CANONICAL=P08172-1" }, "locus": { "chromosome": "7", "start_pos": 137016263, "end_pos": 137014866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000401861.1", "url": "https://www.ensembl.org/id/ENST00000401861.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000384401.1", "url": "https://www.ensembl.org/id/ENSP00000384401.1" } ] } } ], 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asparagine", "start_pos": 6, "start_aa": "Asn", "end_pos": 6, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn6", "evidence": [ { "id": "P08172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08172#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 9, "start_aa": "Asn", "end_pos": 9, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn9", "evidence": [ { "id": "P08172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08172#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P08172", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P08172" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [ { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P08172", "url": "https://www.uniprot.org/uniprot/P08172" }, { "database": "phospho.ELM", "id": "P08172", "url": "http://phospho.elm.eu.org/byAccession/P08172.html" }, { "database": "iPTMnet", "id": "P08172", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08172" }, { "database": "PubMed", "id": "8132675", "url": "https://glygen.org/publication/PubMed/8132675" } ], "site_lbl": "Ser232" }, { "start_pos": 234, "end_pos": 234, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P08172", "url": "http://phospho.elm.eu.org/byAccession/P08172.html" }, { "database": "iPTMnet", "id": "P08172", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08172" }, { "database": "PubMed", "id": "8132675", "url": "https://glygen.org/publication/PubMed/8132675" } ], "site_lbl": "Ser234" }, { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P08172", "url": "http://phospho.elm.eu.org/byAccession/P08172.html" }, { "database": "iPTMnet", "id": "P08172", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08172" }, { "database": "PubMed", "id": "8132675", "url": "https://glygen.org/publication/PubMed/8132675" } ], "site_lbl": "Ser250" }, { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P08172", "url": "http://phospho.elm.eu.org/byAccession/P08172.html" }, { "database": "iPTMnet", "id": "P08172", "url": 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