{ "uniprot_canonical_ac": "P08118-1", "uniprot_ac": "P08118", "uniprot_id": "MSMB_HUMAN", "mass": { "chemical_mass": 12865.0, "monoisotopic_mass": 12865.0 }, "refseq": { "ac": "NP_002434", "name": "beta-microseminoprotein isoform a precursor", "summary": "The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" }, "gene_names": [ { "name": "MSMB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08118", "id": "P08118" }, { "name": "HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP; PSP-94; PSP57; PSP94", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434", "id": "NP_002434" }, { "name": "MSMB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434", "id": "NP_002434" }, { "name": "PRSP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P08118", "id": "P08118" } ], "protein_names": [ { "name": "Beta-microseminoprotein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08118" }, { "name": "IGBF", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "Immunoglobulin-binding factor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "PN44", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "PSP-94", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "PSP94", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "Prostate secreted seminal plasma protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "Prostate secretory protein of 94 amino acids", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "Seminal plasma beta-inhibin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08118" }, { "name": "beta-microseminoprotein isoform a precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434", "id": "NP_002434" }, { "name": "seminal plasma beta-inhibin; prostate secreted seminal plasma protein; immunoglobulin binding factor; beta-microseminoprotein; prostate secretory protein of 94 amino acids", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434", "id": "NP_002434" } ], "function": [ { "annotation": "A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" }, { "database": "PubMed", "id": "31773691", "url": "https://glygen.org/publication/PubMed/31773691" } ] }, { "annotation": "Aggressive prostate tumors suppress MSMB synthesis in the benign prostate and this could explain why serum levels of MSMB are decreased in prostate cancer patients.", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" }, { "database": "PubMed", "id": "29250809", "url": "https://glygen.org/publication/PubMed/29250809" } ] }, { "annotation": "Low plasma microseminoprotein-beta levels are associated with prostate cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" }, { "database": "PubMed", "id": "31089709", "url": "https://glygen.org/publication/PubMed/31089709" } ] }, { "annotation": "Studies indicate prostate secretory protein of 94 amino acids (PSP94) as a prostate tumor marker [Review]. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" }, { "database": "PubMed", "id": "28930560", "url": "https://glygen.org/publication/PubMed/28930560" } ] }, { "annotation": "The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" } ] }, { "annotation": "Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" }, { "database": "PubMed", "id": "33122083", "url": "https://glygen.org/publication/PubMed/33122083" } ] } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ], "evidence": [ { "id": "611928", "database": "MIM", "url": "https://www.omim.org/entry/611928" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "44.03", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000263639", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000263639" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "62.5", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000263639", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000263639" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "91.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000263639", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000263639" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000263639", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000263639" } ] }, { "tissue": { "name": "Esophagus", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P08118", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08118" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08118" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P08118", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08118" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"ETEIICC", "url": "https://omabrowser.org/oma/group/ETEIICC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5388943at2759", "url": "http://www.orthodb.org/?query=5388943at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10500", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10500", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10500:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10500:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2IZ3", "url": "https://www.rcsb.org/structure/2IZ3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IX0", "url": "https://www.rcsb.org/structure/3IX0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF05825", "url": "http://pfam.xfam.org/family/PF05825", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P08118", 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"Protein" ] } ], "sequence": { "sequence": "MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII", "length": 114, "header": "sp|P08118-1|MSMB_HUMAN Isoform 1 of Beta-microseminoprotein OS=Homo sapiens OX=9606 GN=MSMB PE=1 SV=1 CANONICAL=P08118-1" }, "isoforms": [ { "isoform_ac": "A0A590UJG9-1", "url": "", "sequence": { "sequence": "MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLFVSMTVFLHLWVMTKTTAKESSRRRTASISWWRRRTQKRPVLSVNG", "length": 118, "header": "tr|A0A590UJG9-1|A0A590UJG9_HUMAN Computationally mapped isoform of Beta-microseminoprotein OS=Homo sapiens OX=9606 GN=MSMB PE=3 SV=1 CANONICAL=P08118-1" }, "locus": { "chromosome": "10", "start_pos": 46046237, "end_pos": 46033430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000663171.1", "url": "https://www.ensembl.org/id/ENST00000663171.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499419.1", "url": "https://www.ensembl.org/id/ENSP00000499419.1" } ] } }, { "isoform_ac": "P08118-1", "url": "", "sequence": { "sequence": "MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII", "length": 114, "header": "sp|P08118-1|MSMB_HUMAN Isoform 1 of Beta-microseminoprotein OS=Homo sapiens OX=9606 GN=MSMB PE=1 SV=1 CANONICAL=P08118-1" }, "locus": { "chromosome": "10", "start_pos": 46046237, "end_pos": 46033425, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000582163.3", "url": "https://www.ensembl.org/id/ENST00000582163.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000463092.1", "url": "https://www.ensembl.org/id/ENSP00000463092.1" } ] } }, { "isoform_ac": "P08118-2", "url": "", "sequence": { "sequence": "MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRMFLHLWVMTKTTAKESSRRRTASISWWRRRTQKRPVLSVNG", "length": 77, "header": "sp|P08118-2|MSMB_HUMAN Isoform 2 of Beta-microseminoprotein OS=Homo sapiens OX=9606 GN=MSMB PE=1 SV=1 CANONICAL=P08118-1" }, "locus": { "chromosome": "10", "start_pos": 46046237, "end_pos": 46033430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000581478.5", "url": "https://www.ensembl.org/id/ENST00000581478.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000462641.1", "url": "https://www.ensembl.org/id/ENSP00000462641.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "New world, but not old world, monkeys carry several genes encoding beta-microseminoprotein.", "journal": "Eur. J. Biochem.", "date": "1999", "authors": "M\u00e4kinen M, Valtonen-Andr\u00e9 C, Lundwall A", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "10491085", "url": "https://glygen.org/publication/PubMed/10491085" } ] }, { "title": "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.", "journal": "Proteomics", "date": "2002", "authors": "Ghafouri B, Stahlbom B, Tagesson C, Lindahl M", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "11788998", "url": "https://glygen.org/publication/PubMed/11788998" } ] }, { "title": "Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids.", "journal": "Biochem. J.", "date": "2005", "authors": "Reeves JR, Xuan JW, Arfanis K, Morin C, Garde SV, Ruiz MT, Wisniewski J, Panchal C, Tanner JE", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "15344909", "url": "https://glygen.org/publication/PubMed/15344909" } ] }, { "title": "Solution structures of human and porcine beta-microseminoprotein.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Ghasriani Houman, Teilum Kaare, Johnsson Ylva, Fernlund Per, Drakenberg Torbj\u00f6rn", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "16930619", "url": "https://glygen.org/publication/PubMed/16930619" } ] }, { "title": "Multiple loci identified in a genome-wide association study of prostate cancer.", "journal": "Nat. Genet.", "date": "2008", "authors": "Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hayes RB, Hunter DJ, Chanock SJ", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "18264096", "url": "https://glygen.org/publication/PubMed/18264096" } ] }, { "title": "Structural identity of immunoglobulin binding factor and prostatic secretory protein of human seminal plasma.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1991", "authors": "Liang ZG, Kamada M, Koide SS", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "1930232", "url": "https://glygen.org/publication/PubMed/1930232" } ] }, { "title": "Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer.", "journal": "J. Mol. Biol.", "date": "2010", "authors": "Kumar Ashwani, Jagtap Dhanashree D, Mahale Smita D, Kumar Mukesh", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "20184897", "url": "https://glygen.org/publication/PubMed/20184897" } ] }, { "title": "Prostatic secretory protein PSP94: gene organization and promoter sequence in rhesus monkey and human.", "journal": "Biochim. Biophys. Acta", "date": "1991", "authors": "Nolet S, Mbikay M, Chretien M", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "2054385", "url": "https://glygen.org/publication/PubMed/2054385" } ] }, { "title": "Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.", "journal": "Hum. Mutat.", "date": "2013", "authors": "FitzGerald Liesel M, Zhang Xiaotun, Kolb Suzanne, Kwon Erika M, Liew Ying Ching, Hurtado-Coll Antonio, Knudsen Beatrice S, Ostrander Elaine A, Stanford Janet L", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "22887727", "url": "https://glygen.org/publication/PubMed/22887727" } ] }, { "title": "Cloning and nucleotide sequence analysis of the human beta-microseminoprotein gene.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1990", "authors": "Green C B, Liu W Y, Kwok S C", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "2322265", "url": "https://glygen.org/publication/PubMed/2322265" } ] }, { "title": "Molecular cloning of a small prostate protein, known as beta-microseminoprotein, PSP94 or beta-inhibin, and demonstration of transcripts in non-genital tissues.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1989", "authors": "Ulvsb\u00e4ck M, Lindstr\u00f6m C, Weiber H, Abrahamsson P A, Lilja H, Lundwall A", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "2590204", "url": "https://glygen.org/publication/PubMed/2590204" } ] }, { "title": "Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.", "journal": "Frontiers in bioscience (Landmark edition)", "date": "2018", "authors": "Anklesaria JH, Mhatre DR, Mahale SD", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" } ], "reference": [ { "type": "PubMed", "id": "28930560", "url": "https://glygen.org/publication/PubMed/28930560" } ] }, { "title": "Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.", "journal": "The Prostate", "date": "2018", "authors": "Bergstrom SH, Jaremo H, Nilsson M, Adamo HH, Bergh A", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" } ], "reference": [ { "type": "PubMed", "id": "29250809", "url": "https://glygen.org/publication/PubMed/29250809" } ] }, { "title": "The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition.", "journal": "Annals of oncology : official journal of the European Society for Medical Oncology", "date": "2019", "authors": "Smith Byrne K, Appleby PN, Key TJ, Holmes MV, Fensom GK, Agudo A, Ardanaz E, Boeing H, Bueno-de-Mesquita HB, Chirlaque MD, Kaaks R, Larranaga N, Palli D, Perez-Cornago A, Quiros JR, Ricceri F, Sanchez MJ, Tagliabue G, Tsilidis KK, Tumino R, Fortner RT, Ferrari P, Riboli E, Lilja H, Travis RC", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" } ], "reference": [ { "type": "PubMed", "id": "31089709", "url": "https://glygen.org/publication/PubMed/31089709" } ] }, { "title": "A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.", "journal": "European review for medical and pharmacological sciences", "date": "2019", "authors": "Fu S, Huang YL, Luan T, Li N, Wang HF, Wang JS", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" } ], "reference": [ { "type": "PubMed", "id": "31773691", "url": "https://glygen.org/publication/PubMed/31773691" } ] }, { "title": "Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.", "journal": "Gene", "date": "2021", "authors": "Wang X, Hayes JE, Xu X, Gao X, Mehta D, Lilja HG, Klein RJ", "evidence": [ { "database": "RefSeq", "id": "NP_002434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002434" } ], "reference": [ { "type": "PubMed", "id": "33122083", "url": "https://glygen.org/publication/PubMed/33122083" } ] }, { "title": "Molecular cloning and sequence of the cDNA for a 94-amino-acid seminal plasma protein secreted by the human prostate.", "journal": "DNA", "date": "1987", "authors": "Mbikay M, Nolet S, Fournier S, Benjannet S, Chapdelaine P, Paradis G, Dub\u00e9 J Y, Tremblay R, Lazure C, Seidah N G", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "3829888", "url": "https://glygen.org/publication/PubMed/3829888" } ] }, { "title": "The amino acid sequence of human beta-microseminoprotein.", "journal": "Biochim. Biophys. Acta", "date": "1985", "authors": "Akiyama K, Yoshioka Y, Schmid K, Offner G D, Troxler R F, Tsuda R, Hara M", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "3995056", "url": "https://glygen.org/publication/PubMed/3995056" } ] }, { "title": "Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site.", "journal": "FEBS Lett.", "date": "1984", "authors": "Seidah N G, Arbatti N J, Rochemont J, Sheth A R, Chr\u00e9tien M", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "6434350", "url": "https://glygen.org/publication/PubMed/6434350" } ] }, { "title": "Decreased expression of prostatic secretory protein PSP94 in prostate cancer.", "journal": "Cancer Lett.", "date": "1993", "authors": "Liu A Y, Bradner R C, Vessella R L", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "7506990", "url": "https://glygen.org/publication/PubMed/7506990" } ] }, { "title": "Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue.", "journal": "Oncogene", "date": "1995", "authors": "Xuan J W, Chin J L, Guo Y, Chambers A F, Finkelman M A, Clarke M W", "evidence": [ { "database": "UniProtKB", "id": "P08118", "url": "https://www.uniprot.org/uniprot/P08118" } ], "reference": [ { "type": "PubMed", "id": "7566962", "url": "https://glygen.org/publication/PubMed/7566962" } ] }, { "title": "Human seminal plasma beta-microseminoprotein: its purification, characterization, and immunohistochemical localization.", "journal": "Int. 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