{ "uniprot_canonical_ac": "P08069-1", "uniprot_ac": "P08069", "uniprot_id": "IGF1R_HUMAN", "mass": { "chemical_mass": 154793.0, "monoisotopic_mass": 154793.0 }, "refseq": { "ac": "NP_000866", "name": "insulin-like growth factor 1 receptor isoform 1 precursor", "summary": "This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" }, "gene_names": [ { "name": "IGF1R", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08069", "id": "P08069" }, { "name": "CD221; IGFIR; IGFR; JTK13", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866", "id": "NP_000866" }, { "name": "IGF1R", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866", "id": "NP_000866" } ], "protein_names": [ { "name": "Insulin-like growth factor 1 receptor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08069" }, { "name": "2.7.10.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08069" }, { "name": "IGF-I receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866", "id": "NP_000866" }, { "name": "IGF-I receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08069" }, { "name": "Insulin-like growth factor I receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08069" }, { "name": "insulin-like growth factor 1 receptor isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866", "id": "NP_000866" } ], "function": [ { "annotation": "Dysregulation of the IGF-IR internal ribosomal entry site through changes in the activities of RNA-binding translation-regulatory proteins could be responsible for IGF-IR overexpression in a proportion of human breast tumors.", "evidence": [ { "database": "RefSeq", "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" }, { "database": "PubMed", "id": "18452152", "url": "https://glygen.org/publication/PubMed/18452152" } ] }, { "annotation": "IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" }, { "database": "PubMed", "id": "37777542", "url": "https://glygen.org/publication/PubMed/37777542" } ] }, { "annotation": "Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells.", "evidence": [ { "database": "RefSeq", "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" }, { "database": "PubMed", "id": "38036052", "url": "https://glygen.org/publication/PubMed/38036052" } ] }, { "annotation": "MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.", "evidence": [ { "database": "RefSeq", "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" }, { "database": "PubMed", "id": "37752233", "url": "https://glygen.org/publication/PubMed/37752233" } ] }, { "annotation": "Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069#function" } ] }, { "annotation": "The HIFIA/LINC02913/IGF1R axis promotes the cell function of adipose-derived mesenchymal stem cells under hypoxia via activating the PI3K/AKT pathway. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" }, { "database": "PubMed", "id": "37848931", "url": "https://glygen.org/publication/PubMed/37848931" } ] }, { "annotation": "This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866" } ] }, { "annotation": "When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069#function" } ] } ], "disease": [ { "disease_id": "MONDO:0010038", "recommended_name": { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "growth delay due to insulin-like growth factor I resistance", "description": "Growth delay due to IGF-I resistance is characterized by variable intrauterine and postnatal growth retardation and elevated serum IGF-I levels. Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum)." }, "synonyms": [ { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "growth delay due to insulin-like growth factor I resistance", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "resistance to IGF-1", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "IGF-1 resistance", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "IGF-I resistance", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "IGF1RES", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "Somatomedin end-organ insensitivity to", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "Somatomedin, end-organ insensitivity to", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "Somatomedin-C, resistance to", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "Somatomedin-c resistance to", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "insulin-like Growth Factor I, resistance to, due to increased binding Protein", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "insulin-like growth factor 1 resistance to", "description": "" }, { "id": "MONDO:0010038", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010038", "name": "insulin-like growth factor I, resistance to", "description": "" }, { "id": "MIM:270450", "resource": "MIM", "url": "https://www.omim.org/entry/270450", "name": "Insulin-like growth factor 1 resistance", "description": "Insulin-like growth factor 1 resistance" } ], "evidence": [ { "id": "270450", "database": "MIM", "url": "https://www.omim.org/entry/270450" } ] } ], "snv": [ { "evidence": [ { "id": "rs1166303467", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1166303467" }, { "id": "rs1166303467", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1166303467" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 316, "end_pos": 316, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SQS->NQS); n-glyco-sequon-loss (NGS->NGN).", "chr_id": "15", "chr_pos": "98891631", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S316", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1596445440", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1596445440" }, { "id": "rs1596445440", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1596445440" } ], "glycoeffect": [ "n-glyco-sequon-loss", "n-glyco-sequon-gain" ], "start_pos": 640, "end_pos": 640, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->TLS); n-glyco-sequon-gain (NGN->NGT).", "chr_id": "15", "chr_pos": "98916054", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N640", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1446546249", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1446546249" }, { "id": "rs1446546249", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1446546249" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 102, "end_pos": 102, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->KLT).", "chr_id": "15", "chr_pos": "98707773", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N102", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765988181", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765988181" }, { "id": "rs765988181", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765988181" }, { "id": "rs765988181", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765988181#frequency_tab" }, { "id": "rs765988181", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765988181" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1038, "end_pos": 1038, "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NEA->NES).", "chr_id": "15", "chr_pos": "98934982", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A1038", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765988181", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765988181" }, { "id": "rs765988181", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765988181" }, { "id": "rs765988181", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765988181#frequency_tab" }, { "id": "rs765988181", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765988181" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1038, "end_pos": 1038, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NEA->NET).", "chr_id": "15", "chr_pos": "98934982", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A1038", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1335469497", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1335469497" }, { "id": "rs1335469497", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1335469497" }, { "id": "rs1335469497", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1335469497#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 104, "end_pos": 104, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NLM).", "chr_id": "15", "chr_pos": "98707778", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T104", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1157438489", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1157438489" }, { "id": "rs1157438489", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1157438489#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1129, "end_pos": 1129, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAN->NAS).", "chr_id": "15", "chr_pos": "98939289", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N1129", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs35385418", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35385418" }, { "id": "rs35385418", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs35385418" }, { "id": "rs35385418", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35385418" }, { "id": "rs35385418", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs35385418#frequency_tab" }, { "id": "rs35385418", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs35385418" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 134, "end_pos": 134, "sequence_org": "R", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLR->NLS).", "chr_id": "15", "chr_pos": "98707869", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.00619", "site_lbl": "R134", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1567223658", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1567223658" }, { "id": "rs1567223658", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1567223658" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1352, "end_pos": 1352, "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGG->NGS).", "chr_id": "15", "chr_pos": "98957392", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G1352", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1161811268", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1161811268" }, { "id": "rs1161811268", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1161811268" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 137, "end_pos": 137, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 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"minor_allelic_frequency": "", "site_lbl": "N244", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs146427969", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146427969" }, { "id": "rs146427969", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs146427969" }, { "id": "rs146427969", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146427969" }, { "id": "rs146427969", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146427969#frequency_tab" }, { "id": "rs146427969", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146427969" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 244, "end_pos": 244, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NDT->SDT).", "chr_id": "15", "chr_pos": "98891415", "ref_nt": "G", "alt_nt": "null", 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disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P08069", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08069" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P08069", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08069" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P08069", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08069" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P08069", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08069" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P08069", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08069" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P08069" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"https://www.rcsb.org/structure/6VWH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VWI", "url": "https://www.rcsb.org/structure/6VWI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VWJ", "url": "https://www.rcsb.org/structure/6VWJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7PH8", "url": "https://www.rcsb.org/structure/7PH8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7S0Q", "url": "https://www.rcsb.org/structure/7S0Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7S8V", "url": "https://www.rcsb.org/structure/7S8V", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7U23", "url": "https://www.rcsb.org/structure/7U23", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7V3P", "url": "https://www.rcsb.org/structure/7V3P", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7XGD", "url": "https://www.rcsb.org/structure/7XGD", "database": "PDB", 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"http://pfam.xfam.org/family/PF00041", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00757", "url": "http://pfam.xfam.org/family/PF00757", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01030", "url": "http://pfam.xfam.org/family/PF01030", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "http://pfam.xfam.org/family/PF07714", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P08069", "url": "https://pharos.nih.gov/targets/P08069", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:000054420", "url": "https://proconsortium.org/app/entry/PR:000054420", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_P08069", "url": "http://purl.obolibrary.org/obo/PR_P08069", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-2404192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2404192", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-2428928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2428928", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-2428933", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2428933", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009391", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9820960", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820960", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_000866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000866", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P08069", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "C9J5X1", "url": "https://www.uniprot.org/uniprot/C9J5X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J5X1-1", "url": "https://www.uniprot.org/uniprot/C9J5X1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YMJ5", "url": "https://www.uniprot.org/uniprot/H0YMJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YMJ5-1", "url": "https://www.uniprot.org/uniprot/H0YMJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YNR0", "url": "https://www.uniprot.org/uniprot/H0YNR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YNR0-1", "url": "https://www.uniprot.org/uniprot/H0YNR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BSZ8", "url": "https://www.uniprot.org/uniprot/H3BSZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BSZ8-1", "url": "https://www.uniprot.org/uniprot/H3BSZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08069-1", "url": "https://www.uniprot.org/uniprot/P08069-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC", "length": 1367, "header": "sp|P08069-1|IGF1R_HUMAN Isoform 1 of Insulin-like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 CANONICAL=P08069-1" }, "isoforms": [ { "isoform_ac": "C9J5X1-1", "url": "", "sequence": { "sequence": "MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKRYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC", "length": 1366, "header": "tr|C9J5X1-1|C9J5X1_HUMAN Computationally mapped isoform of Tyrosine-protein kinase receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 CANONICAL=P08069-1" }, "locus": { "chromosome": "15", "start_pos": 98957439, "end_pos": 98649582, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000649865.1", "url": "https://www.ensembl.org/id/ENST00000649865.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496919.1", "url": "https://www.ensembl.org/id/ENSP00000496919.1" } ] } }, { "isoform_ac": "H0YMJ5-1", "url": "", "sequence": { "sequence": "MTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGF", "length": 190, "header": "tr|H0YMJ5-1|H0YMJ5_HUMAN Computationally mapped isoform of receptor protein-tyrosine kinase OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 CANONICAL=P08069-1" }, "locus": { "chromosome": "15", "start_pos": 98891617, "end_pos": 98707831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000558355.1", "url": "https://www.ensembl.org/id/ENST00000558355.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000453630.1", "url": "https://www.ensembl.org/id/ENSP00000453630.1" } ] } }, { "isoform_ac": "H0YNR0-1", "url": "", "sequence": { "sequence": "MQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPP", "length": 212, "header": "tr|H0YNR0-1|H0YNR0_HUMAN Computationally mapped isoform of Insulin like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 CANONICAL=P08069-1" }, "locus": { "chromosome": "15", "start_pos": 98911397, "end_pos": 98891594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000558898.1", "url": "https://www.ensembl.org/id/ENST00000558898.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000454115.1", "url": "https://www.ensembl.org/id/ENSP00000454115.1" } ] } }, { "isoform_ac": "H3BSZ8-1", "url": "", "sequence": { "sequence": "XTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVNREVEPSLSAQRQPELLHCALAAAASGRLPLPAQLLLQRQNPHQEVCRRHHRH", "length": 90, "header": "tr|H3BSZ8-1|H3BSZ8_HUMAN Computationally mapped isoform of Insulin like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1 CANONICAL=P08069-1" }, "locus": { "chromosome": "15", "start_pos": 98916716, "end_pos": 98913176, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000560144.1", "url": "https://www.ensembl.org/id/ENST00000560144.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000456950.1", "url": "https://www.ensembl.org/id/ENSP00000456950.1" } ] } }, { "isoform_ac": "P08069-1", "url": "", "sequence": { "sequence": 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034224", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "positive regulation of cytokinesis", "id": "GO:0032467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032467", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "positive regulation of protein-containing complex disassembly", "id": "GO:0043243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043243", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "negative regulation of cholangiocyte apoptotic process", "id": "GO:1904193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904193", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "cellular response to insulin-like growth factor stimulus", "id": "GO:1990314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990314", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "amyloid-beta clearance", "id": "GO:0097242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097242", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "dendritic spine maintenance", "id": "GO:0097062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097062", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "negative regulation of muscle cell apoptotic process", "id": "GO:0010656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010656", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "cardiac atrium development", "id": "GO:0003230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003230", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "alphav-beta3 integrin-IGF-1-IGF1R complex", "id": "GO:0035867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035867", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "caveola", "id": "GO:0005901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005901", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "T-tubule", "id": "GO:0030315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030315", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "protein kinase complex", "id": "GO:1902911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902911", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin receptor complex", "id": "GO:0005899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005899", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 15, "go_terms": [ { "name": "insulin receptor activity", "id": "GO:0005009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005009", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "G-protein alpha-subunit binding", "id": "GO:0001965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001965", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin-like growth factor binding", "id": "GO:0005520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin-like growth factor receptor activity", "id": "GO:0005010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005010", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin receptor substrate binding", "id": "GO:0043560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043560", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase binding", "id": "GO:0043548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043548", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin binding", "id": "GO:0043559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043559", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "insulin-like growth factor I binding", "id": "GO:0031994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031994", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "protein transporter activity", "id": "GO:0140318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140318", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase activity", "id": "GO:0004714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004714", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "insulin-like growth factor 1 receptor O-glycosylated 1 (human)", "definition": "An insulin-like growth factor 1 receptor (human) that has been O-glycosylated at the residue equivalent to Thr-684 of the amino acid sequence represented by UniProtKB:P08069-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08069-1, Thr-684, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000054420", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054420" } ] } ], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 607, "end_pos": 609, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 640, "end_pos": 642, "annotation": "n_glycosylation_sequon" }, { "start_pos": 747, "end_pos": 749, "annotation": "n_glycosylation_sequon" }, { "start_pos": 756, "end_pos": 758, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 900, "end_pos": 902, "annotation": "n_glycosylation_sequon" }, { "start_pos": 913, "end_pos": 915, "annotation": "n_glycosylation_sequon" }, { "start_pos": 963, "end_pos": 965, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Controlled by regulated intramembrane proteolysis (RIP). Undergoes metalloprotease-dependent constitutive ectodomain shedding to produce a membrane-anchored 52 kDa C-Terminal fragment which is further processed by presenilin gamma-secretase to yield an intracellular 50 kDa fragment.", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" }, { "database": "PubMed", "id": "17524361", "url": "https://glygen.org/publication/PubMed/17524361" } ] }, { "annotation": "Polyubiquitinated at Lys-1168 and Lys-1171 through both 'Lys-48' and 'Lys-29' linkages, promoting receptor endocytosis and subsequent degradation by the proteasome. Ubiquitination is facilitated by pre-existing phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" }, { "database": "PubMed", "id": "12821780", "url": "https://glygen.org/publication/PubMed/12821780" }, { "database": "PubMed", "id": "11694888", "url": "https://glygen.org/publication/PubMed/11694888" }, { "database": "PubMed", "id": "18501599", "url": "https://glygen.org/publication/PubMed/18501599" }, { "database": "PubMed", "id": "19041240", "url": "https://glygen.org/publication/PubMed/19041240" }, { "database": "PubMed", "id": "7541045", "url": "https://glygen.org/publication/PubMed/7541045" }, { "database": "PubMed", "id": "21994939", "url": "https://glygen.org/publication/PubMed/21994939" } ] }, { "annotation": "Sumoylated with SUMO1.", "evidence": [ { "database": "UniProtKB", "id": "P08069", "url": "https://www.uniprot.org/uniprot/P08069" }, { "database": "PubMed", "id": "20596523", "url": "https://glygen.org/publication/PubMed/20596523" } ] } ], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WUD9-1", "P57760-1", "P35739-1", "F1LYY7-1", "A0A8I6GCV6-1", "Q63132-1", "Q63117-1", "Q5U2X5-1", "Q63474-1", "Q4V8A3-1", "O08680-1", "O35346-1", "P54757-1", "P54758-1", "P54759-1", "P70600-1", "Q00495-1", "Q03351-1", "Q04589-1", "P06494-1", "P09759-1", "P29321-1", "P32577-1", "Q6XUX2-1", "Q62662-1", "Q62799-1", "Q62844-1", "Q62956-1", "Q63184-1", "Q63470-1", "Q498D6-1", "Q01621-1", "Q6P6U0-1", "Q63604-1", "P09760-1", "Q01986-1", "Q62862-1", "Q63572-1", "Q07014-1", "Q4KSH7-1", "G3V9H8-1", "P15127-1", "O08775-1", "P53767-1", "Q05030-1", "P55146-1", "Q64725-1", "Q63802-1", "Q64716-1", "P09215-1", "Q62689-1", "F1LM93-1", "P36506-1", "P20786-1", "P24062-1", "Q924U5-1", "Q63272-1", "B2RYC7-1", "P41243-1", "M0RDA4-1", "Q62838-1", "Q63116-1", "A0A8I6AM23-1", "P50545-1", "P57097-1", "P97523-1", "Q91ZT1-1", "D4A7W7-1", "F1LVI0-1", "E9PSY0-1", "A0A0G2K6M9-1", "F1LSN4-1", "F1MAJ0-1", "A0A0R4J8U1-1", "A0A8I6A5T6-1", "D3ZDS3-1", "D4ADZ5-1", "F1LSG7-1", "F1LRZ0-1", "D3ZBN3-1", "F1M0N1-1", "G3V6K6-1", "D3ZD03-1", "D3ZZK3-1", "E9PT20-1", "D4A584-1", "D3ZDH4-1", "A0A8I5ZVE3-1", "A0A8I6AWX7-1", "Q4KM97-1", "Q501W1-1", "B5DFD6-1", "Q5FVG7-1", "D3ZCD0-1", "A0A8I5ZP97-1", "A0A0G2JW59-1", "B1WC09-1", "Q01134-1", "P11980-1", "G3V783-1", "D3ZJI4-1", "Q4KSH6-1", "M0R7E7-1", "Q925D6-1", "Q9UM73-1", "O15146-1", "P42679-1", "P08922-1", "P07947-1", "Q12866-1", "P00519-1", "Q07912-1", "P42684-1", "Q9UF33-1", "P10721-1", "P08069-1", "P06239-1", "P04626-1", "P51451-1", "Q06187-1", "P51813-1", "Q9UIG0-1", "P49760-1", "P49761-4", "Q9HAZ1-1", "P49759-1", "P07333-1", "Q5JZY3-1", "Q6XUX3-1", "P00533-1", "Q9Y463-1", "P29317-1", "Q9NR20-1", "Q13627-1", "P54760-1", "P41240-1", "Q16832-1", "Q15375-1", "P29323-1", "P22455-1", "P16591-1", "P29322-1", "P54756-1", "P29320-1", "Q08345-1", "Q92630-1", "P54753-1", "Q15303-1", "P21860-1", "Q14289-1", "O43781-1", "P54764-1", "P19525-1", "P21709-1", "P54762-1", "P22607-1", "P21802-1", "P52333-1", "P11362-1", "P42685-1", "P06213-1", "P14616-1", "Q05655-1", "Q08881-1", "P07332-1", "P08631-1", "P29376-1", "Q05397-1", "O60674-1", "P23458-1", "P36888-1", "P09769-1", "P06241-1", "P43405-1", "P07948-1", "P46734-1", "P45985-1", "Q02750-1", "P52564-1", "O14733-1", "Q13163-1", "Q16288-1", "P36507-1", "Q16620-1", "P08581-1", "P04629-1", "Q14680-1", "Q01974-1", "P09619-1", "P07949-1", "Q504Y2-1", "P34925-1", "P16234-1", "Q13882-1", "Q04912-1", "O43353-1", "Q06418-1", "P30530-1", "Q96KB5-1", "Q15569-1", "Q96S53-1", "Q6J9G0-1", "P42680-1", "P35916-2", "P0C1S8-1", "P17948-1", "P29597-1", "P42681-1", "P35590-1", "Q13470-1", "P33981-1", "P30291-1", "P12931-1", "P35968-1", "P43403-1", "O75716-1", "Q02763-1", "Q9H3Y6-1", "P35790-1", "P14618-1", "P24604-1", "Q9Z188-1", "P35969-1", "P52332-1", "P08923-1", "Q00342-1", "Q62120-1", "Q4JIM5-1", "P97504-1", "P42682-1", "Q60629-1", "O54967-1", "P00520-1", "P97793-1", "P16277-1", "O35491-1", "O35492-1", "O35493-1", "Q9Z277-1", "P35991-1", "P22518-1", "Q8BYG9-1", "P54754-1", "P54761-1", "Q6XUX1-1", "Q62371-1", "Q60750-1", "Q61527-1", "Q62413-1", "Q61214-1", "Q61772-1", "Q61851-1", "Q922Y0-1", "Q922K9-1", "O09127-1", "P16092-1", "Q03142-1", "P29319-1", "Q01279-1", "P70424-1", "P21803-1", "Q8CBF3-1", "P41241-1", "Q03963-1", "Q8BI55-1", "P54763-3", "P16879-1", "P09581-1", "P34152-3", "P14234-1", "P39688-1", "Q03146-1", "Q03145-1", "Q61526-1", "P70451-1", "Q5U4C9-1", "Q9QVP9-1", "Q03137-1", "Q60751-1", "Q62137-1", "P28867-1", "P25911-1", "P48025-1", "Q9WTL4-1", "P41242-1", "P05532-1", "P06240-1", "P08103-1", "P15208-1", "Q03526-1", "Q9WVS7-1", "P70236-1", "P31938-1", "P47809-1", "Q61846-1", "Q60805-1", "Q63932-1", "O09110-1", "P26618-1", "Q8CE90-1", "P16056-1", "P05622-1", "P15209-1", "Q6VNS1-1", "Q61006-1", "Q3UFB7-1", "Q5RJI4-1", "Q9JJ78-1", "P58801-1", "Q8VCT9-1", "O70146-1", "Q62190-1", "Q62270-1", "P35546-1", "P35761-1", "Q9Z138-1", "Q9R117-1", "O88697-1", "P05480-2", "Q01887-1", "Q02858-1", "Q06806-1", "Q00993-1", "Q64434-1", "Q6J9G1-1", "Q99ML2-1", "Q78DX7-1", "P55144-1", "P43404-1", "P35917-1", "P47810-1", "P35918-1", "Q04736-1", "Q66JT0-1", "O54804-1", "P52480-1", "P14680-1", "P21965-1", "P22216-1", "P32490-1", "P06784-1", "P08018-1", "P32350-1", "P32491-1", "P54199-1", "Q54G28-1", "Q54N73-1", "Q54R58-1", "P18160-1", "P18161-1", "Q54BC9-1", "Q54I36-1", "Q54QV3-1", "Q552C6-1", "Q55CL6-1", "Q75JK0-1", "Q76NV1-1", "Q23977-1", "P18475-1", "P13368-1", "Q24145-1", "Q24488-1", "Q27324-1", "P08630-1", "P00522-1", "P00528-1", "P04412-1", "Q9V422-1", "Q9V6K3-1", "Q9V9J3-1", "Q9VBW3-1", "P09208-1", "P49762-1", "P83102-1", "Q24324-1", "Q9VPC0-1", "P49657-1", "P54350-1", "P18106-4", "Q07407-1", "Q09147-1", "Q24592-1", "Q9I7F7-1", "Q9V3D5-1", "Q9VZI2-1", "Q8INJ8-1", "Q7KJ08-1", "Q9VJ04-1", "E1JHB7-1", "Q9VE06-1", "O61444-1", "O62602-1", "Q9VZA8-1", "Q7KT06-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-HSA-2404193", "name": "IGF1R phosphorylates SHC1", "equation": "", "summary": "The phosphorylated IGF1R phosphorylates SHC1 (Giorgetti et al. 1994, Hernandez-Sanchez et al. 1995, Kim et al. 1998). Phosphorylation of SHC1 is sustained whereas phosphorylation of IRS2 by IGF1R is transient (Kim et al. 1998).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2404193", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2404193" } ] }, { "id": "R-HSA-2404195", "name": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1", "equation": "", "summary": "SHC binds the NPEY-juxtamembrane motif of the phosphorylated insulin-like growth factor receptor (IGF1R) (Giorgetti et al. 1994, Tartare-Deckert et al. 1995).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2404195", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2404195" } ] }, { "id": "R-HSA-2404199", "name": "IGF1,2:IGF1R autophosphorylates", "equation": "", "summary": "The beta peptide of the type 1 insulin-like growth factor (IGF1R) spans the plasma membrane and trans-autophosphorylates tyrosine residues in response to binding of either IGF1 or IGF2 by the extracellular alpha peptide (LeBon et al. 1986, Yu et al. 1986, Doronio et al. 1990, Hernandez-Sanchez et al. 1995, Alvino et al. 2001).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2404199", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2404199" } ] }, { "id": "R-HSA-2404200", "name": "IGF1,2 binds IGF1R", "equation": "", "summary": "Either IGF1 (IGF-I) or IGF2 (IGF-II) can bind the type 1 insulin-like growth factor receptor (IGF1R) (Casella et al. 1986, LeBon et al. 1986, Maly and Luthi 1986, Cacieri et al. 1988, Steele-Perkins et al. 1988, Burgisser et al. 1991, Germain-Lee et al. 1992, Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011). IGF1R has similar affinities for IGF1 and IGF2 (Casella et al. 1986, Steele-Perkins et al. 1988). The binding sites for IGF1 and IGF2 are in a similar location on the alpha peptide of IGF1R but there are some differences in which residues of IGF1R interact with IGF1 vs. IGF2 (Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2404200", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2404200" } ] }, { "id": "R-HSA-2428922", "name": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2", "equation": "", "summary": "IRS2 binds the NPEY-juxtamembrane motif of phosphorylated IGF1R (He et al. 1996, Kim et al. 1998). IRS2 is cytosolic while IRS1 and IRS4 are located in the plasma membrane.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2428922", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2428922" } ] }, { "id": "R-HSA-2428926", "name": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4", "equation": "", "summary": "Phosphorylated IGF1R phosphorylates IRS1 (Siemeister et al. 1995, Xu et al. 1995, Takahashi et al. 1997, Rakatzi et al. 2006), IRS2 (Kim et al. 1998, Kim et al. 2004), and IRS4 (Fantin et al.1998, Karas et al. 2001, Cuevas et al. 2007) on numerous tyrosine residues. IRS4 is phosphorylated by IGF1R in HEK cells but not in primary muscle cells (Fantin et al. 1998, Schreyer et al. 2003). The phosphotyrosine resideus create binding sites for downstream effectors such as GRB2:SOS and PI3K.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2428926", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2428926" } ] }, { "id": "R-HSA-2428930", "name": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4", "equation": "", "summary": "IRS1 binds the NPEY-juxtamembrane motif of phosphorylated IGF1R (Craparo et al. 1995, He et al. 1995, Huang et al. 2001). IRS4 is also involved in signaling by IGF1R and is presumed to bind phosphorylated IGF1R in the same way as IRS1 (Qu et al. 1999, Cuevas et al. 2007). IRS1 and IRS4 are located at the plasma membrane (Karlsson et al. 2004, Fantin et al. 1998).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-2428930", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2428930" } ] }, { "id": "R-HSA-5686072", "name": "p-3Y-SHC1 dissociates from IGF1R", "equation": "", "summary": "Release of tyrosine-phosphorylated SHC from IGF1R triggers a cascade of signalling events via SOS, RAF and the MAP kinases.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-5686072", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686072" } ] }, { "id": "R-HSA-9624272", "name": "MMPs cleave HB-EGF", "equation": "", "summary": "Estrogen-stimulation of ESR1 activates downstream signaling pathways that results in the release of HB-EGF in an IGF- MMP- and EGFR-dependent manner (Razandi et al, 2003; Song et al, 2004; Song et al, 2007; Santen et al, 2009). Based on studies in other systems, candidate MMPs for the cleavage of HB-EGF include MMP2, MMP3, MMP7 and MMP9 (Suzuki et al, 1997; Yu et al, 2002; Razandi et al, 2003). Although direct cleavage of HB-EGF by MMPs downstream of estrogen signaling has not been demonstrated, estrogen-stimulated signaling through EGFR is abrogated after treatment of cells with an HB-EGF neutralizing antibody (Razandi et al, 2003; Song et al, 2007).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-HSA-9624270" ], "enzyme_list": [ "P08069-1", "P14780-1", "P08253-1", "P09237-1", "P08254-1" ], "evidence": [ { "id": "R-HSA-9624272", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9624272" } ] }, { "id": "R-HSA-9634584", "name": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen", "equation": "", "summary": "Estrogen stimulates phosphorylation of the insulin-like growth factor 1 receptor (IGF1R) in a manner that depends on ESR1 but is independent of stimulation by the cognate IGF1 ligand (Richards et al, 1996; Richards et al, 1998; Kleinman et al, 1995; Lee et al, 1999; Kahlert et al, 2000; Song et al, 2002; Song et al, 2004). Estrogen-dependent phosphorylation of IGF1R depends on a physical interaction between the estrogen-bound estrogen receptor and IGF1R and may be promoted by SHC1 and SRC, although the molecular details are not established (Song et al, 2004). In one model, interaction of liganded ESR1 with SHC promotes the activation of SRC and active SRC then phosphorylates IGF1R at tyrosine residues required for SHC interaction. In this way, both SHC and liganded-ESR1 would be brought to IGF1R in a SRC-dependent manner. Consistent with this, SHC has been shown to activate SRC; however, this model has not been rigorously validated (Sato et al, 2002; Song et al, 2004). E2-stimulated IGF1R pathway activation also depends on activation of the MAPK pathway, as IGF1R phosphorylation is abrogated upon treatment of cells with MAPKK inhibitors (Kahlert et al, 2000; Song et al, 2004).
In addition to MAPK pathway activation, E2-dependent IGF1R activation promotes signaling through the EGFR pathway in a manner that depends on MMP2 and MMP9, suggesting that the cross-talk is mediated at the level of liberation of HBEGF from the plasma membrane (Song et al, 2004; Song et al, 2007, Santen et al, 2009). The details of this connection also remain to be fleshed out.", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08069-1" ], "evidence": [ { "id": "R-HSA-9634584", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634584" } ] }, { "id": "R-HSA-9837625", "name": "hRSV A enters host cell through macropinocytosis", "equation": "", "summary": "The study of human respiratory syncytial virus (RSV) A entry into HeLa and A549 cells using fluorescence microscopy and quantitative FACS assays has shown that, after attachment, RSV rapidly enters host cells by an actin-dependent process with characteristics of macropinocytosis. Findings are similar when primary bronchial epithelial cells are used (Krzyzaniak et al. 2013). Macropinocytosis requires activation of receptor tyrosine kinases (RTKs). The only RTK activated in experiments with HeLa and A549 cells is EGFR, and EGFR inhibitors block RSV entry (Krzyzaniak et al. 2013). EGFR has been reported to interact with the F protein of some RSV strains (Currier et al. 2016). However, in the airway epithelium, EGFR is mainly expressed in basal cells while the RTK IGF1R has been shown to be the binding partner for the F protein in the hRSV A2 strain and is required for RSV entry into ciliated epithelial cells of the airways (Griffiths et al. 2020). Protein kinase C signaling appears to be important for macropinocytosis-mediated entry of RSV (Krzyzaniak et al. 2013). Protein kinase C zeta (PRKCZ) has been shown to be activated downstream of IGF1R and seems to be important for RSV entry as it increases the concentration of the F protein binding partner, NCL, at the surface of ciliated airway epithelium (Griffiths et al. 2020). NCL has been reported to be involved in promotion of macropinocytosis (Reyes-Reyes et al. 2010; Reyes-Reyes et al. 2015). Other host cell factors implicated in RSV macropinocytosis are PI3K, RAC1 and CDC42 GTPases, PAK1 kinase - downstream effector of RAC1 and CDC42, myosin II - PAK1 target, Na+/H+ exchangers, and RAB5 macropinosome marker (Krzyzaniak et al. 2013).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51148-1", "P00533-1", "P20339-1", "P08069-1", "P61020-1" ], "evidence": [ { "id": "R-HSA-9837625", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9837625" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-9624270", "participant_name": "HB-EGF(161-208) [plasma membrane]", "crossref": [ { "id": "Q99075", "database": "Pharos - Targets", "url": "" }, { "id": "ENSP00000230990", "database": "Ensembl", "url": "" }, { "id": "ENSG00000113070", "database": "OpenTargets", "url": "" }, { "id": "ENSG00000113070", "database": "Ensembl", "url": "" }, { "id": "ENST00000230990", "database": "Ensembl", "url": "" }, { "id": "ENSG00000113070-HBEGF", "database": "HPA", "url": "" }, { "id": "Q99075", "database": "PRO", "url": "" }, { "id": "2M8S", "database": "PDB", "url": "" }, { "id": "1XDT", "database": "PDB", "url": "" }, { "id": "Q99075", "database": "GeneCards", "url": "" }, { "id": "Q99075", "database": "UniProt", "url": "" }, { "id": "HMDBP02701", "database": "HMDB Protein", "url": "" }, { "id": "NP_001936.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JW59", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] } ] }, { "uniprot_ac": "A0A0G2K6M9", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] } ] }, { "uniprot_ac": "A0A0R4J8U1", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] } ] }, { "uniprot_ac": "A0A8I5ZP97", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] } ] }, { "uniprot_ac": "A0A8I5ZVE3", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] } ] }, { "uniprot_ac": "A0A8I6A5T6", "gene_name": "Mst1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] } ] }, { "uniprot_ac": "A0A8I6AM23", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] } ] }, { "uniprot_ac": "A0A8I6AWX7", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] } ] }, { "uniprot_ac": "A0A8I6GCV6", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] } ] }, { "uniprot_ac": "B1WC09", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] } ] }, { "uniprot_ac": "B2RYC7", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] } ] }, { "uniprot_ac": "B5DFD6", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] } ] }, { "uniprot_ac": "D3ZBN3", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] } ] }, { "uniprot_ac": "D3ZCD0", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] } ] }, { "uniprot_ac": "D3ZD03", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] } ] }, { "uniprot_ac": "D3ZDH4", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] } ] }, { "uniprot_ac": "D3ZDS3", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] } ] }, { "uniprot_ac": "D3ZJI4", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] } ] }, { "uniprot_ac": "D3ZZK3", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] } ] }, { "uniprot_ac": "D4A584", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] } ] }, { "uniprot_ac": "D4A7W7", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] } ] }, { "uniprot_ac": "D4ADZ5", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "E9PSY0", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] } ] }, { "uniprot_ac": "E9PT20", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] } ] }, { "uniprot_ac": "F1LM93", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] } ] }, { "uniprot_ac": "F1LRZ0", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] } ] }, { "uniprot_ac": "F1LSG7", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] } ] }, { "uniprot_ac": "F1LSN4", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] } ] }, { "uniprot_ac": "F1LVI0", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] } ] }, { "uniprot_ac": "F1LYY7", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] } ] }, { "uniprot_ac": "F1M0N1", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] } ] }, { "uniprot_ac": "F1MAJ0", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] } ] }, { "uniprot_ac": "G3V6K6", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "G3V9H8", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] } ] }, { "uniprot_ac": "M0R7E7", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] } ] }, { "uniprot_ac": "M0RDA4", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] } ] }, { "uniprot_ac": "O08680", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] } ] }, { "uniprot_ac": "O08775", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] } ] }, { "uniprot_ac": "O09110", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] } ] }, { "uniprot_ac": "O09127", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] } ] }, { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] } ] }, { "uniprot_ac": "O15146", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] } ] }, { "uniprot_ac": "O35346", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] } ] }, { "uniprot_ac": "O35491", "gene_name": "Clk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] } ] }, { "uniprot_ac": "O35492", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] } ] }, { "uniprot_ac": "O35493", "gene_name": "Clk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] } ] }, { "uniprot_ac": "O54804", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] } ] }, { "uniprot_ac": "O54967", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] } ] }, { "uniprot_ac": "O60674", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "O62602", "gene_name": "lic", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] } ] }, { "uniprot_ac": "O70146", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] } ] }, { "uniprot_ac": "O88697", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] } ] }, { "uniprot_ac": "P00519", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] } ] }, { "uniprot_ac": "P00520", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P00533", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P04626", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] } ] }, { "uniprot_ac": "P04629", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] } ] }, { "uniprot_ac": "P05480", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] } ] }, { "uniprot_ac": "P05532", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] } ] }, { "uniprot_ac": "P05622", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] } ] }, { "uniprot_ac": "P06239", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] } ] }, { "uniprot_ac": "P06240", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] } ] }, { "uniprot_ac": "P06241", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] } ] }, { "uniprot_ac": "P06494", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] } ] }, { "uniprot_ac": "P06784", "gene_name": "STE7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] } ] }, { "uniprot_ac": "P07332", "gene_name": "FES", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] } ] }, { "uniprot_ac": "P07333", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] } ] }, { "uniprot_ac": "P07947", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] } ] }, { "uniprot_ac": "P07948", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] } ] }, { "uniprot_ac": "P07949", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] } ] }, { "uniprot_ac": "P08018", "gene_name": "PBS2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] } ] }, { "uniprot_ac": "P08069", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] } ] }, { "uniprot_ac": "P08103", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] } ] }, { "uniprot_ac": "P08253", "gene_name": "MMP2", "activity": [ { "ec_number": "3.4.24.24", "activity": "Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.", "evidence": [ { "id": "P08253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08253" } ] }, { "ec_number": "3.4.24.24", "activity": "", "evidence": [ { "id": "P08253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08253" } ] } ] }, { "uniprot_ac": "P08254", "gene_name": "MMP3", "activity": [ { "ec_number": "3.4.24.17", "activity": "Preferential cleavage where P1', P2' and P3' are hydrophobic residues.", "evidence": [ { "id": "P08254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08254" } ] }, { "ec_number": "3.4.24.17", "activity": "", "evidence": [ { "id": "P08254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08254" } ] } ] }, { "uniprot_ac": "P08581", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] } ] }, { "uniprot_ac": "P08630", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] } ] }, { "uniprot_ac": "P08631", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] } ] }, { "uniprot_ac": "P08922", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] } ] }, { "uniprot_ac": "P08923", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] } ] }, { "uniprot_ac": "P09208", "gene_name": "InR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P09237", "gene_name": "MMP7", "activity": [ { "ec_number": "3.4.24.23", "activity": "Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I).", "evidence": [ { "id": "P09237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09237" } ] }, { "ec_number": "3.4.24.23", "activity": "", "evidence": [ { "id": "P09237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09237" } ] } ] }, { "uniprot_ac": "P09581", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09581" } ] } ] }, { "uniprot_ac": "P09619", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] } ] }, { "uniprot_ac": "P09759", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] } ] }, { "uniprot_ac": "P09760", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] } ] }, { "uniprot_ac": "P0C1S8", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] } ] }, { "uniprot_ac": "P10721", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] } ] }, { "uniprot_ac": "P11362", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12931", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] } ] }, { "uniprot_ac": "P13368", "gene_name": "sev", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] } ] }, { "uniprot_ac": "P14234", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] } ] }, { "uniprot_ac": "P14616", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14680", "gene_name": "YAK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] } ] }, { "uniprot_ac": "P14780", "gene_name": "MMP9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P14780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14780" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P14780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14780" } ] } ] }, { "uniprot_ac": "P15127", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] } ] }, { "uniprot_ac": "P15208", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] } ] }, { "uniprot_ac": "P15209", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] } ] }, { "uniprot_ac": "P16056", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] } ] }, { "uniprot_ac": "P16092", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] } ] }, { "uniprot_ac": "P16234", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] } ] }, { "uniprot_ac": "P16277", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] } ] }, { "uniprot_ac": "P16591", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] } ] }, { "uniprot_ac": "P16879", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] } ] }, { "uniprot_ac": "P17948", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P18160", "gene_name": "splA", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] } ] }, { "uniprot_ac": "P18161", "gene_name": "splB", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] } ] }, { "uniprot_ac": "P18475", "gene_name": "tor", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] } ] }, { "uniprot_ac": "P20339", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20339" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P20339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20339" } ] } ] }, { "uniprot_ac": "P20786", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] } ] }, { "uniprot_ac": "P21709", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] } ] }, { "uniprot_ac": "P21802", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] } ] }, { "uniprot_ac": "P21803", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] } ] }, { "uniprot_ac": "P21860", "gene_name": "ERBB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] } ] }, { "uniprot_ac": "P21965", "gene_name": "MCK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] } ] }, { "uniprot_ac": "P22216", "gene_name": "RAD53", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] } ] }, { "uniprot_ac": "P22455", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] } ] }, { "uniprot_ac": "P22518", "gene_name": "Clk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] } ] }, { "uniprot_ac": "P22607", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] } ] }, { "uniprot_ac": "P23458", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] } ] }, { "uniprot_ac": "P24062", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] } ] }, { "uniprot_ac": "P24604", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] } ] }, { "uniprot_ac": "P25911", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] } ] }, { "uniprot_ac": "P26618", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P29317", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] } ] }, { "uniprot_ac": "P29319", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] } ] }, { "uniprot_ac": "P29320", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] } ] }, { "uniprot_ac": "P29321", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] } ] }, { "uniprot_ac": "P29322", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] } ] }, { "uniprot_ac": "P29323", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] } ] }, { "uniprot_ac": "P29376", "gene_name": "LTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] } ] }, { "uniprot_ac": "P29597", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] } ] }, { "uniprot_ac": "P30530", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] } ] }, { "uniprot_ac": "P31938", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] } ] }, { "uniprot_ac": "P32350", "gene_name": "KNS1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] } ] }, { "uniprot_ac": "P32490", "gene_name": "MKK1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] } ] }, { "uniprot_ac": "P32491", "gene_name": "MKK2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] } ] }, { "uniprot_ac": "P32577", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] } ] }, { "uniprot_ac": "P34152", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] } ] }, { "uniprot_ac": "P34925", "gene_name": "RYK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] } ] }, { "uniprot_ac": "P35546", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] } ] }, { "uniprot_ac": "P35590", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] } ] }, { "uniprot_ac": "P35739", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] } ] }, { "uniprot_ac": "P35761", "gene_name": "Ttk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] } ] }, { "uniprot_ac": "P35790", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] } ] }, { "uniprot_ac": "P35916", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] } ] }, { "uniprot_ac": "P35917", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] } ] }, { "uniprot_ac": "P35918", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] } ] }, { "uniprot_ac": "P35968", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] } ] }, { "uniprot_ac": "P35969", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] } ] }, { "uniprot_ac": "P35991", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] } ] }, { "uniprot_ac": "P36506", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] } ] }, { "uniprot_ac": "P36888", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] } ] }, { "uniprot_ac": "P39688", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] } ] }, { "uniprot_ac": "P41240", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] } ] }, { "uniprot_ac": "P41241", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] } ] }, { "uniprot_ac": "P41242", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] } ] }, { "uniprot_ac": "P41243", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] } ] }, { "uniprot_ac": "P42679", "gene_name": "MATK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] } ] }, { "uniprot_ac": "P42680", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] } ] }, { "uniprot_ac": "P42681", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] } ] }, { "uniprot_ac": "P42682", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] } ] }, { "uniprot_ac": "P42684", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] } ] }, { "uniprot_ac": "P42685", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] } ] }, { "uniprot_ac": "P43403", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] } ] }, { "uniprot_ac": "P43404", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] } ] }, { "uniprot_ac": "P43405", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] } ] }, { "uniprot_ac": "P47809", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] } ] }, { "uniprot_ac": "P47810", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] } ] }, { "uniprot_ac": "P48025", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P50545", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] } ] }, { "uniprot_ac": "P51148", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P51148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51148" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P51148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51148" } ] } ] }, { "uniprot_ac": "P51451", "gene_name": "BLK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] } ] }, { "uniprot_ac": "P51813", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] } ] }, { "uniprot_ac": "P52332", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] } ] }, { "uniprot_ac": "P52333", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] } ] }, { "uniprot_ac": "P53767", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] } ] }, { "uniprot_ac": "P54199", "gene_name": "MPS1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] } ] }, { "uniprot_ac": "P54350", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] } ] }, { "uniprot_ac": "P54753", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] } ] }, { "uniprot_ac": "P54754", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] } ] }, { "uniprot_ac": "P54756", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] } ] }, { "uniprot_ac": "P54757", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] } ] }, { "uniprot_ac": "P54758", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] } ] }, { "uniprot_ac": "P54759", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] } ] }, { "uniprot_ac": "P54760", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] } ] }, { "uniprot_ac": "P54761", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] } ] }, { "uniprot_ac": "P54762", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] } ] }, { "uniprot_ac": "P54763", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] } ] }, { "uniprot_ac": "P54764", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] } ] }, { "uniprot_ac": "P55144", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] } ] }, { "uniprot_ac": "P55146", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] } ] }, { "uniprot_ac": "P57097", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] } ] }, { "uniprot_ac": "P57760", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] } ] }, { "uniprot_ac": "P58801", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] } ] }, { "uniprot_ac": "P61020", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61020" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61020" } ] } ] }, { "uniprot_ac": "P70236", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] } ] }, { "uniprot_ac": "P70424", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] } ] }, { "uniprot_ac": "P70451", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] } ] }, { "uniprot_ac": "P70600", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P97504", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] } ] }, { "uniprot_ac": "P97523", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] } ] }, { "uniprot_ac": "P97793", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] } ] }, { "uniprot_ac": "Q00342", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] } ] }, { "uniprot_ac": "Q00495", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] } ] }, { "uniprot_ac": "Q00993", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] } ] }, { "uniprot_ac": "Q01134", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] } ] }, { "uniprot_ac": "Q01279", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] } ] }, { "uniprot_ac": "Q01621", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] } ] }, { "uniprot_ac": "Q01887", "gene_name": "Ryk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] } ] }, { "uniprot_ac": "Q01974", "gene_name": "ROR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] } ] }, { "uniprot_ac": "Q01986", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] } ] }, { "uniprot_ac": "Q02763", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] } ] }, { "uniprot_ac": "Q02858", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] } ] }, { "uniprot_ac": "Q03137", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] } ] }, { "uniprot_ac": "Q03142", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] } ] }, { "uniprot_ac": "Q03145", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] } ] }, { "uniprot_ac": "Q03146", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] } ] }, { "uniprot_ac": "Q03351", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] } ] }, { "uniprot_ac": "Q03526", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q04589", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] } ] }, { "uniprot_ac": "Q04736", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] } ] }, { "uniprot_ac": "Q04912", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] } ] }, { "uniprot_ac": "Q05030", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] } ] }, { "uniprot_ac": "Q05397", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06187", "gene_name": "BTK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] } ] }, { "uniprot_ac": "Q06418", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] } ] }, { "uniprot_ac": "Q06806", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] } ] }, { "uniprot_ac": "Q07014", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] } ] }, { "uniprot_ac": "Q07407", "gene_name": "htl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] } ] }, { "uniprot_ac": "Q07912", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] } ] }, { "uniprot_ac": "Q08345", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] } ] }, { "uniprot_ac": "Q08881", "gene_name": "ITK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] } ] }, { "uniprot_ac": "Q09147", "gene_name": "btl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] } ] }, { "uniprot_ac": "Q12866", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] } ] }, { "uniprot_ac": "Q13163", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] } ] }, { "uniprot_ac": "Q13470", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] } ] }, { "uniprot_ac": "Q13627", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] } ] }, { "uniprot_ac": "Q13882", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] } ] }, { "uniprot_ac": "Q14289", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] } ] }, { "uniprot_ac": "Q14680", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] } ] }, { "uniprot_ac": "Q15303", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] } ] }, { "uniprot_ac": "Q15375", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] } ] }, { "uniprot_ac": "Q15569", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] } ] }, { "uniprot_ac": "Q16288", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] } ] }, { "uniprot_ac": "Q16620", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] } ] }, { "uniprot_ac": "Q16832", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24145", "gene_name": "Shark", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q24488", "gene_name": "Ror", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] } ] }, { "uniprot_ac": "Q24592", "gene_name": "hop", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] } ] }, { "uniprot_ac": "Q27324", "gene_name": "drl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + 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"id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] } ] }, { "uniprot_ac": "Q4KSH6", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { 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L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] } ] }, { "uniprot_ac": "Q54BC9", "gene_name": "dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] } ] }, { "uniprot_ac": "Q54G28", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] } ] }, { "uniprot_ac": "Q54I36", "gene_name": "pyk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] } ] }, { "uniprot_ac": "Q54N73", "gene_name": "7tmk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] } ] }, { "uniprot_ac": "Q54QV3", "gene_name": "yakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] } ] }, { "uniprot_ac": "Q54R58", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] } ] }, { "uniprot_ac": "Q552C6", "gene_name": "zak2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] } ] }, { "uniprot_ac": "Q55CL6", "gene_name": "mekA", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] } ] }, { "uniprot_ac": "Q5FVG7", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] } ] }, { "uniprot_ac": "Q5JZY3", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] } ] }, { "uniprot_ac": "Q5RJI4", "gene_name": "Pkdcc", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] } ] }, { "uniprot_ac": "Q5U2X5", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": 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"Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] } ] }, { "uniprot_ac": "Q60751", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] } ] }, { "uniprot_ac": "Q60805", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + 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+ H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62371" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62371" } ] } ] }, { "uniprot_ac": "Q62413", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] } ] }, { "uniprot_ac": "Q62662", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": 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"id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] } ] }, { "uniprot_ac": "Q62838", "gene_name": "Musk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] } ] }, { "uniprot_ac": "Q62844", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] } ] }, { 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L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] } ] }, { "uniprot_ac": "Q63117", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] } ] }, { "uniprot_ac": "Q63132", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] } ] }, { "uniprot_ac": "Q63184", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] } ] }, { "uniprot_ac": "Q63272", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] } ] }, { "uniprot_ac": "Q63470", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] } ] }, { "uniprot_ac": "Q63474", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] } ] }, { "uniprot_ac": "Q63572", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] } ] }, { "uniprot_ac": "Q63604", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] } ] }, { "uniprot_ac": "Q63802", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] } ] }, { 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L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] } ] }, { "uniprot_ac": "Q64725", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] } ] }, { "uniprot_ac": "Q66JT0", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q66JT0", 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"activity": "", "evidence": [ { "id": "Q6J9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G1" } ] } ] }, { "uniprot_ac": "Q6P6U0", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] } ] }, { "uniprot_ac": "Q6VNS1", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": 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} ] }, { "uniprot_ac": "Q7KT06", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KT06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KT06" } ] } ] }, { "uniprot_ac": "Q8BI55", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] } ] }, { "uniprot_ac": "Q8BYG9", "gene_name": "Epha10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] } ] }, { "uniprot_ac": "Q8CBF3", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] } ] }, { "uniprot_ac": "Q8CE90", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q8VCT9", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] } ] }, { "uniprot_ac": "Q91ZT1", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q91ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q91ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZT1" } ] } ] }, { "uniprot_ac": "Q922K9", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] } ] }, { "uniprot_ac": "Q922Y0", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] } ] }, { "uniprot_ac": "Q924U5", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] } ] }, { "uniprot_ac": "Q925D6", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] } ] }, { "uniprot_ac": "Q92630", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q92630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92630" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q92630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92630" } ] } ] }, { "uniprot_ac": "Q96KB5", "gene_name": "PBK", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96KB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KB5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q96KB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KB5" } ] } ] }, { "uniprot_ac": "Q96S53", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96S53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96S53" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q96S53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96S53" } ] } ] }, { "uniprot_ac": "Q99ML2", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] } ] }, { "uniprot_ac": "Q9H3Y6", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] } ] }, { "uniprot_ac": "Q9HAZ1", "gene_name": "CLK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] } ] }, { "uniprot_ac": "Q9I7F7", "gene_name": "Ack-like", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] } ] }, { "uniprot_ac": "Q9JJ78", "gene_name": "Pbk", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJ78" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q9JJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJ78" } ] } ] }, { "uniprot_ac": "Q9NR20", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9NR20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR20" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9NR20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR20" } ] } ] }, { "uniprot_ac": "Q9QVP9", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9QVP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QVP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9QVP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QVP9" } ] } ] }, { "uniprot_ac": "Q9R117", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9R117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R117" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9R117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R117" } ] } ] }, { "uniprot_ac": "Q9UF33", "gene_name": "EPHA6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9UF33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UF33" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9UF33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UF33" } ] } ] }, { "uniprot_ac": "Q9UIG0", "gene_name": "BAZ1B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9UIG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UIG0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9UIG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UIG0" } ] } ] }, { "uniprot_ac": "Q9UM73", "gene_name": "ALK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9UM73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UM73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9UM73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UM73" } ] } ] }, { "uniprot_ac": "Q9V3D5", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9V3D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3D5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9V3D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3D5" } ] } ] }, { "uniprot_ac": "Q9V422", "gene_name": "dnt", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V422" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V422" } ] } ] }, { "uniprot_ac": "Q9V6K3", "gene_name": "Nrk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V6K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6K3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V6K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6K3" } ] } ] }, { "uniprot_ac": "Q9V9J3", "gene_name": "Src42A", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V9J3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9V9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V9J3" } ] } ] }, { "uniprot_ac": "Q9VBW3", "gene_name": "Cad96Ca", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VBW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBW3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VBW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBW3" } ] } ] }, { "uniprot_ac": "Q9VE06", "gene_name": "cdi", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] } ] }, { "uniprot_ac": "Q9VJ04", "gene_name": "Dmel\\CG10702", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] } ] }, { "uniprot_ac": "Q9VPC0", "gene_name": "Pitslre", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] } ] }, { "uniprot_ac": "Q9VZA8", "gene_name": "Tie", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VZA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZA8" } ] } ] }, { "uniprot_ac": "Q9VZI2", "gene_name": "Ack", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VZI2", "database": 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} ] }, { "uniprot_ac": "Q9Z138", "gene_name": "Ror2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9Z138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z138" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9Z138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z138" } ] } ] }, { "uniprot_ac": "Q9Z188", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Z188", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z188" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9Z188", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z188" } ] } ] }, { "uniprot_ac": "Q9Z277", "gene_name": "Baz1b", "activity": [ { "ec_number": "2.7.10.2", "activity": 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