{ "uniprot_canonical_ac": "P07949-1", "uniprot_ac": "P07949", "uniprot_id": "RET_HUMAN", "mass": { "chemical_mass": 124319.0, "monoisotopic_mass": 124319.0 }, "refseq": { "ac": "NP_065681", "name": "proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor", "summary": "This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681" }, "gene_names": [ { "name": "RET", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07949", "id": "P07949" }, { "name": "CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681", "id": "NP_065681" }, { "name": "CDHF12", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07949", "id": "P07949" }, { "name": "CDHR16", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07949", "id": "P07949" }, { "name": "PTC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07949", "id": "P07949" }, { "name": "RET51", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07949", "id": "P07949" }, { "name": "RET", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681", "id": "NP_065681" } ], "protein_names": [ { "name": "Proto-oncogene tyrosine-protein kinase receptor Ret", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07949" }, { "name": "2.7.10.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07949" }, { "name": "Cadherin family member 12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07949" }, { "name": "Proto-oncogene c-Ret", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07949" }, { "name": "cadherin-related family member 16; RET receptor tyrosine kinase; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); cadherin family member 12; proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene c-Ret; rearranged during transfection", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681", "id": "NP_065681" }, { "name": "proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681", "id": "NP_065681" } ], "function": [ { "annotation": "Clinical characteristics of a large familial cohort with Medullary thyroid cancer and germline Cys618Arg RET mutation in an Israeli multicenter study. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_065681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681" }, { "database": "PubMed", "id": "38027168", "url": "https://glygen.org/publication/PubMed/38027168" } ] }, { "annotation": "Comprehensive molecular analysis identifies RET alterations association with response of ICIs in multi-immunotherapy cohorts.", "evidence": [ { "database": "RefSeq", "id": "NP_065681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681" }, { "database": "PubMed", "id": "38061115", "url": "https://glygen.org/publication/PubMed/38061115" } ] }, { "annotation": "Impact of the overexpression of the tyrosine kinase receptor RET in the hematopoietic potential of induced pluripotent stem cells (iPSCs).", "evidence": [ { "database": "RefSeq", "id": "NP_065681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681" }, { "database": "PubMed", "id": "37921725", "url": "https://glygen.org/publication/PubMed/37921725" } ] }, { "annotation": "Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099).", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949#function" }, { "database": "PubMed", "id": "20702524", "url": "https://glygen.org/publication/PubMed/20702524" }, { "database": "PubMed", "id": "20064382", "url": "https://glygen.org/publication/PubMed/20064382" }, { "database": "PubMed", "id": "20616503", "url": "https://glygen.org/publication/PubMed/20616503" }, { "database": "PubMed", "id": "21357690", "url": "https://glygen.org/publication/PubMed/21357690" }, { "database": "PubMed", "id": "28846097", "url": "https://glygen.org/publication/PubMed/28846097" }, { "database": "PubMed", "id": "21454698", "url": "https://glygen.org/publication/PubMed/21454698" }, { "database": "PubMed", "id": "28846099", "url": "https://glygen.org/publication/PubMed/28846099" }, { "database": "PubMed", "id": "28953886", "url": "https://glygen.org/publication/PubMed/28953886" } ] }, { "annotation": "Thirty Years of Progress Thanks to the RET Oncogene.", "evidence": [ { "database": "RefSeq", "id": "NP_065681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681" }, { "database": "PubMed", "id": "37870964", "url": "https://glygen.org/publication/PubMed/37870964" } ] }, { "annotation": "This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_065681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065681" } ] } ], "disease": [ { "disease_id": "DOID:0050430", "recommended_name": { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia type 2A", "description": "A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis." }, "synonyms": [ { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "MEN2A", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "Sipple syndrome", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "Multiple endocrine neoplasia 2A (MEN2A) syndrome is a form of MEN2 characterized by medullary thyroid carcinoma (MTC) in combination with pheochromocytoma and primary mild hyperparathyroidism resulting from hyperplasia or adenoma of the parathyroid cells." }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEA type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEA type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEN2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "Sipple syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "ptc syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men-2A syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid-producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MIM:171400", "resource": "MIM", "url": "https://www.omim.org/entry/171400", "name": "Multiple neoplasia 2A", "description": "Multiple neoplasia 2A" } ], "evidence": [ { "id": "171400", "database": "MIM", "url": "https://www.omim.org/entry/171400" } ] }, { "disease_id": "DOID:0050547", "recommended_name": { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "familial medullary thyroid carcinoma", "description": "A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance." }, "synonyms": [ { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "THYROID CARCINOMA, FAMILIAL MEDULLARY", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome." }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "hereditary medullary thyroid gland carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "hereditary thyroid medullary carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "Fmtc", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "Mtc1", "description": "" }, { "id": "MIM:155240", "resource": "MIM", "url": "https://www.omim.org/entry/155240", "name": "Medullary thyroid carcinoma", "description": "Medullary thyroid carcinoma" } ], "evidence": [ { "id": "155240", "database": "MIM", "url": "https://www.omim.org/entry/155240" } ] }, { "disease_id": "DOID:0050771", "recommended_name": { "id": "DOID:0050771", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050771", "name": "pheochromocytoma", "description": "An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure." }, "synonyms": [ { "id": "DOID:0050771", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050771", "name": "phaeochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "phaeochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma, susceptibility to", "description": "" }, { "id": "MIM:171300", "resource": "MIM", "url": "https://www.omim.org/entry/171300", "name": "Pheochromocytoma", "description": "Pheochromocytoma" } ], "evidence": [ { "id": "171300", "database": "MIM", "url": "https://www.omim.org/entry/171300" } ] }, { "disease_id": "DOID:10016", "recommended_name": { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "multiple endocrine neoplasia type 2B", "description": "A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities." }, "synonyms": [ { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN type IIB", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN2B", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Multiple endocrine neoplasia, type 3", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "Multiple endocrine neoplasia 2B (MEN2B) syndrome is a rare aggressive form of MEN2 characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal ganglioneuroma, and marfanoid habitus." }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "MEN2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine adenomatosis type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumors", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumours", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal Neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3 (formerly)", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III, formerly", "description": "" }, { "id": "MIM:162300", "resource": "MIM", "url": "https://www.omim.org/entry/162300", "name": "Multiple neoplasia 2B", "description": "Multiple neoplasia 2B" } ], "evidence": [ { "id": "162300", "database": "MIM", "url": "https://www.omim.org/entry/162300" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "evidence": [ { "id": "114500", "database": "MIM", "url": "https://www.omim.org/entry/114500" } ] }, { "disease_id": "MONDO:0007723", "recommended_name": { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "Hirschsprung disease, susceptibility to, 1", "description": "An inherited susceptibility or predisposition to developing Hirschsprung disease in which the cause of the disease is a mutation in the RET gene." }, "synonyms": [ { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "Hirschsprung disease", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "aganglionic megacolon", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "megacolon, aganglionic", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "HSCR1", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "Hirschsprung disease caused by mutation in RET", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "Hirschsprung disease, susceptibility to, 1", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "Hirschsprung disease, susceptibility to, type 1", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007723", "name": "RET Hirschsprung disease", "description": "" }, { "id": "MONDO:0007723", "resource": "MONDO", "url": 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"chr_id": "10", "chr_pos": "43124941", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D1000", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", 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"https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201244749" }, { "id": "rs201244749", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201244749#frequency_tab" }, { "id": "rs201244749", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201244749" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 102, "end_pos": 102, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DHS->NHS).", "chr_id": "10", "chr_pos": "43100689", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "D102", "disease": [ { "disease_id": "DOID:0050547", "recommended_name": { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "familial medullary thyroid carcinoma", "description": "A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance." }, "synonyms": [ { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "THYROID CARCINOMA, FAMILIAL MEDULLARY", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome." }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", 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"https://www.omim.org/entry/155240", "name": "Medullary thyroid carcinoma", "description": "Medullary thyroid carcinoma" } ] }, { "disease_id": "DOID:0050430", "recommended_name": { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia type 2A", "description": "A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis." }, "synonyms": [ { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "MEN2A", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "Sipple syndrome", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine 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"https://monarchinitiative.org/disease/MONDO:0008234", "name": "Sipple syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "ptc syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men-2A syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid-producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MIM:171400", "resource": "MIM", "url": "https://www.omim.org/entry/171400", "name": "Multiple neoplasia 2A", "description": "Multiple neoplasia 2A" } ] }, { "disease_id": "DOID:10016", "recommended_name": { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "multiple endocrine neoplasia type 2B", "description": "A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities." }, "synonyms": [ { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN type IIB", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN2B", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Multiple endocrine neoplasia, type 3", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "Multiple endocrine neoplasia 2B (MEN2B) syndrome is a rare aggressive form of MEN2 characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal ganglioneuroma, and marfanoid habitus." }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "MEN2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine adenomatosis type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumors", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumours", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal Neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3 (formerly)", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III, formerly", "description": "" }, { "id": "MIM:162300", "resource": "MIM", "url": "https://www.omim.org/entry/162300", "name": "Multiple neoplasia 2B", "description": "Multiple neoplasia 2B" } ] }, { "disease_id": "DOID:0050771", "recommended_name": { "id": "DOID:0050771", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050771", "name": "pheochromocytoma", "description": "An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure." }, "synonyms": [ { "id": "DOID:0050771", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050771", "name": "phaeochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "phaeochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma, susceptibility to", "description": "" }, { "id": "MIM:171300", "resource": "MIM", "url": "https://www.omim.org/entry/171300", "name": "Pheochromocytoma", "description": "Pheochromocytoma" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "P07949", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07949" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1046, "end_pos": 1046, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NNA->NNS).", "chr_id": "10", "chr_pos": "43126671", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A1046", "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0008234", "name": "ptc syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men-2A syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid-producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MIM:171400", "resource": "MIM", "url": "https://www.omim.org/entry/171400", "name": "Multiple neoplasia 2A", "description": "Multiple neoplasia 2A" } ] }, { "disease_id": "DOID:10016", "recommended_name": { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "multiple endocrine neoplasia type 2B", "description": "A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities." }, "synonyms": [ { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN type IIB", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN2B", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Multiple endocrine neoplasia, type 3", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "Multiple endocrine neoplasia 2B (MEN2B) syndrome is a rare aggressive form of MEN2 characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal ganglioneuroma, and 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"https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine adenomatosis type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumors", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumours", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal Neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3 (formerly)", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III, formerly", "description": "" }, { "id": "MIM:162300", "resource": "MIM", "url": "https://www.omim.org/entry/162300", "name": "Multiple neoplasia 2B", "description": "Multiple neoplasia 2B" } ] }, { "disease_id": "DOID:0050771", "recommended_name": { "id": "DOID:0050771", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050771", "name": "pheochromocytoma", "description": "An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure." }, "synonyms": [ { "id": "DOID:0050771", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050771", "name": "phaeochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "phaeochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma", "description": "" }, { "id": "MONDO:0008233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008233", "name": "pheochromocytoma, susceptibility to", "description": "" }, { "id": "MIM:171300", "resource": "MIM", "url": "https://www.omim.org/entry/171300", "name": "Pheochromocytoma", "description": "Pheochromocytoma" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs150261092", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150261092" }, { "id": "rs150261092", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150261092" }, { "id": "rs150261092", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs150261092#frequency_tab" }, { "id": "rs150261092", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs150261092" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 151, "end_pos": 151, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTS->STS).", "chr_id": "10", "chr_pos": "43102456", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N151", "disease": [ { "disease_id": "DOID:0050547", "recommended_name": { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "familial medullary thyroid carcinoma", "description": "A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance." }, "synonyms": [ { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "THYROID CARCINOMA, FAMILIAL MEDULLARY", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome." }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "hereditary medullary thyroid gland carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "hereditary thyroid medullary carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "Fmtc", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "Mtc1", "description": "" }, { "id": "MIM:155240", "resource": "MIM", "url": "https://www.omim.org/entry/155240", "name": "Medullary thyroid carcinoma", "description": "Medullary thyroid carcinoma" } ] }, { "disease_id": "DOID:0050430", "recommended_name": { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia type 2A", "description": "A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis." }, "synonyms": [ { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "MEN2A", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "Sipple syndrome", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "Multiple endocrine neoplasia 2A (MEN2A) syndrome is a form of MEN2 characterized by medullary thyroid carcinoma (MTC) in combination with pheochromocytoma and primary mild hyperparathyroidism resulting from hyperplasia or adenoma of the parathyroid cells." }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEA type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEA type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEN2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "Sipple syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "ptc syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men-2A syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid-producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MIM:171400", "resource": "MIM", "url": "https://www.omim.org/entry/171400", "name": "Multiple neoplasia 2A", "description": "Multiple neoplasia 2A" } ] }, { "disease_id": "DOID:10016", "recommended_name": { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "multiple endocrine neoplasia type 2B", "description": "A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities." }, "synonyms": [ { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN type IIB", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN2B", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Multiple endocrine neoplasia, type 3", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "Multiple endocrine neoplasia 2B (MEN2B) syndrome is a rare aggressive form of MEN2 characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal ganglioneuroma, and marfanoid habitus." }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "MEN2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", 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large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "ptc syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men-2A syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid-producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MIM:171400", "resource": "MIM", "url": "https://www.omim.org/entry/171400", "name": "Multiple neoplasia 2A", "description": "Multiple neoplasia 2A" } ] }, { "disease_id": "DOID:10016", "recommended_name": { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "multiple endocrine neoplasia type 2B", "description": "A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities." }, "synonyms": [ { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN type IIB", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN2B", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Multiple endocrine neoplasia, type 3", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "Multiple endocrine neoplasia 2B (MEN2B) syndrome is a rare aggressive form of MEN2 characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal ganglioneuroma, and marfanoid habitus." }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "MEN2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine adenomatosis type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumors", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumours", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal Neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3 (formerly)", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III, formerly", "description": "" }, { "id": "MIM:162300", "resource": "MIM", "url": "https://www.omim.org/entry/162300", "name": "Multiple neoplasia 2B", "description": "Multiple neoplasia 2B" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs549907428", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs549907428" }, { "id": "rs549907428", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs549907428" }, { "id": "rs549907428", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs549907428" }, { "id": "rs549907428", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs549907428#frequency_tab" }, { "id": "rs549907428", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs549907428" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 448, "end_pos": 448, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCS->KCS).", "chr_id": "10", "chr_pos": "43111287", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000599", "site_lbl": "N448", "disease": [ { "disease_id": "DOID:0050547", "recommended_name": { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "familial medullary thyroid carcinoma", "description": "A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance." }, "synonyms": [ { "id": "DOID:0050547", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050547", "name": "THYROID CARCINOMA, FAMILIAL MEDULLARY", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome." }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "familial medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "hereditary medullary thyroid gland carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "hereditary thyroid medullary carcinoma", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "Fmtc", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "MTC", "description": "" }, { "id": "MONDO:0007958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007958", "name": "Mtc1", "description": "" }, { "id": "MIM:155240", "resource": "MIM", "url": "https://www.omim.org/entry/155240", "name": "Medullary thyroid carcinoma", "description": "Medullary thyroid carcinoma" } ] }, { "disease_id": "DOID:0050430", "recommended_name": { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia type 2A", "description": "A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis." }, "synonyms": [ { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "MEN2A", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "Sipple syndrome", "description": "" }, { "id": "DOID:0050430", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050430", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "Multiple endocrine neoplasia 2A (MEN2A) syndrome is a form of MEN2 characterized by medullary thyroid carcinoma (MTC) in combination with pheochromocytoma and primary mild hyperparathyroidism resulting from hyperplasia or adenoma of the parathyroid cells." }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEA type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEA type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "MEN2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "Sipple syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type 2a", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine adenomatosis, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type II", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "ptc syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "men-2A syndrome", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type 2A", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "multiple endocrine neoplasia, type IIA", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "pheochromocytoma and amyloid-producing medullary thyroid carcinoma", "description": "" }, { "id": "MONDO:0008234", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008234", "name": "thyroid carcinoma, familial medullary", "description": "" }, { "id": "MIM:171400", "resource": "MIM", "url": "https://www.omim.org/entry/171400", "name": "Multiple neoplasia 2A", "description": "Multiple neoplasia 2A" } ] }, { "disease_id": "DOID:10016", "recommended_name": { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "multiple endocrine neoplasia type 2B", "description": "A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities." }, "synonyms": [ { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN type IIB", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "MEN2B", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Multiple endocrine neoplasia, type 3", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "DOID:10016", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10016", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "Multiple endocrine neoplasia 2B (MEN2B) syndrome is a rare aggressive form of MEN2 characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal ganglioneuroma, and marfanoid habitus." }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "MEN2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Wagenmann-Froboese syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "men type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine adenomatosis type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 2B", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type IIB", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type 3", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "multiple endocrine neoplasia, type III", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumors", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "Neuromata, mucosal, with endocrine tumours", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008082", "name": "mucosal Neuroma syndrome", "description": "" }, { "id": "MONDO:0008082", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P07949", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07949" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P07949", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07949" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07949" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P07949", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07949" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P07949", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07949" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS", "length": 1114, "header": "sp|P07949-1|RET_HUMAN Isoform 1 of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=3 CANONICAL=P07949-1" }, "isoforms": [ { "isoform_ac": "A0A087WWB1-1", "url": "", "sequence": { "sequence": "MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF", "length": 940, "header": "tr|A0A087WWB1-1|RET_HUMAN Computationally mapped isoform of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43126751, "end_pos": 43077259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000615310.5", "url": "https://www.ensembl.org/id/ENST00000615310.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000480088.2", "url": "https://www.ensembl.org/id/ENSP00000480088.2" } ] } }, { "isoform_ac": "A0A1W2PPN7-1", "url": "", "sequence": { "sequence": "XDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNVADAPTDLTSLCRPRLSPAHRLPQGLPVTHIPS", "length": 114, "header": "tr|A0A1W2PPN7-1|A0A1W2PPN7_HUMAN Computationally mapped isoform of Ret proto-oncogene OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43102404, "end_pos": 43100484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638465.1", "url": "https://www.ensembl.org/id/ENST00000638465.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000491505.1", "url": "https://www.ensembl.org/id/ENSP00000491505.1" } ] } }, { "isoform_ac": "A0A1W2PSA1-1", "url": "", "sequence": { "sequence": "XDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRTCSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGECRPCGAAPQCLLLLVLLCEPLTQAIWFILHLHAISSFNIPEVPLACLPGARYCSRS", "length": 191, "header": "tr|A0A1W2PSA1-1|A0A1W2PSA1_HUMAN Computationally mapped isoform of Ret proto-oncogene OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43102804, "end_pos": 43100484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000640619.1", "url": "https://www.ensembl.org/id/ENST00000640619.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492728.1", "url": "https://www.ensembl.org/id/ENSP00000492728.1" } ] } }, { "isoform_ac": "A0A5F9ZHB7-1", "url": "", "sequence": { "sequence": "MAKATSGAAGLRLLLLLLLPLLGKDRESLCGKLPGIQWHQRPVQAAFLWCQLQHARGGHLSRGHLGDPVCE", "length": 71, "header": "tr|A0A5F9ZHB7-1|RET_HUMAN Computationally mapped isoform of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43111346, "end_pos": 43077259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000672389.1", "url": "https://www.ensembl.org/id/ENST00000672389.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000500252.1", "url": "https://www.ensembl.org/id/ENSP00000500252.1" } ] } }, { "isoform_ac": "A0A5F9ZHR6-1", "url": "", "sequence": { "sequence": "MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEDRESLCGKLPGIQWHQRPVQAAFLWCQLQHARGGHLSRGHLGDPVCE", "length": 255, "header": "tr|A0A5F9ZHR6-1|RET_HUMAN Computationally mapped isoform of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43111346, "end_pos": 43077259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000671844.1", "url": "https://www.ensembl.org/id/ENST00000671844.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000500541.1", "url": "https://www.ensembl.org/id/ENSP00000500541.1" } ] } }, { "isoform_ac": "A0A804HIK7-1", "url": "", "sequence": { "sequence": "XDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNLTSLCRPRLSPAHRLPQGLPVTHIPS", "length": 107, "header": "tr|A0A804HIK7-1|A0A804HIK7_HUMAN Computationally mapped isoform of Ret proto-oncogene OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43102404, "end_pos": 43100484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000683278.1", "url": "https://www.ensembl.org/id/ENST00000683278.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000507117.1", "url": "https://www.ensembl.org/id/ENSP00000507117.1" } ] } }, { "isoform_ac": "A0A804HL71-1", "url": "", "sequence": { "sequence": "XDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGECRPCGAAPQCLLLLVLLCEPLTQAIWFILHLHAISSFNIPEVPLACLPGARYCSRS", "length": 234, "header": "tr|A0A804HL71-1|A0A804HL71_HUMAN Computationally mapped isoform of Ret proto-oncogene OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43102804, "end_pos": 43100484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684216.1", "url": "https://www.ensembl.org/id/ENST00000684216.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508223.1", "url": "https://www.ensembl.org/id/ENSP00000508223.1" } ] } }, { "isoform_ac": "C9JYL6-1", "url": "", "sequence": { "sequence": "MAKATSGAAGLRLLLLLLLPLLGKDVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFA", "length": 181, "header": "tr|C9JYL6-1|RET_HUMAN Computationally mapped isoform of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=1 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43114592, "end_pos": 43077259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000498820.5", "url": "https://www.ensembl.org/id/ENST00000498820.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000419080.1", "url": "https://www.ensembl.org/id/ENSP00000419080.1" } ] } }, { "isoform_ac": "P07949-1", "url": "", "sequence": { "sequence": "MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS", "length": 1114, "header": "sp|P07949-1|RET_HUMAN Isoform 1 of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=3 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43128266, "end_pos": 43077259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000355710.8", "url": "https://www.ensembl.org/id/ENST00000355710.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000347942.3", "url": "https://www.ensembl.org/id/ENSP00000347942.3" } ] } }, { "isoform_ac": "P07949-2", "url": "", "sequence": { "sequence": "MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF", "length": 1072, "header": "sp|P07949-2|RET_HUMAN Isoform 2 of Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens OX=9606 GN=RET PE=1 SV=3 CANONICAL=P07949-1" }, "locus": { "chromosome": "10", "start_pos": 43126751, "end_pos": 43077259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000340058.6", "url": "https://www.ensembl.org/id/ENST00000340058.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000344798.4", "url": "https://www.ensembl.org/id/ENSP00000344798.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 151, "start_aa": "Asn", "end_pos": 151, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn151", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" }, { "id": "20473317", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20473317" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 179, "start_aa": "Asn", "end_pos": 179, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn179", "evidence": [ { "id": "2X2U", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/2X2U" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 199, "start_aa": "Asn", "end_pos": 199, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn199", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 336, "start_aa": "Asn", "end_pos": 336, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn336", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 343, "start_aa": "Asn", "end_pos": 343, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn343", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 361, "start_aa": "Asn", "end_pos": 361, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn361", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 367, "start_aa": "Asn", "end_pos": 367, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn367", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 377, "start_aa": "Asn", "end_pos": 377, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn377", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": 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a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation.", "journal": "Oncogene", "date": "1999", "authors": "Gimm O, Neuberg DS, Marsh DJ, Dahia PL, Hoang-Vu C, Raue F, Hinze R, Dralle H, Eng C", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "10022819", "url": "https://glygen.org/publication/PubMed/10022819" } ] }, { "title": "Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation.", "journal": "Japanese journal of cancer research : Gann", "date": "1999", "authors": "Miyauchi A, Futami H, Hai N, Yokozawa T, Kuma K, Aoki N, Kosugi S, Sugano K, Yamaguchi K", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": 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"database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10323403", "url": "https://glygen.org/publication/PubMed/10323403" } ] }, { "title": "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.", "journal": "Oncogene", "date": "1999", "authors": "Klugbauer S, Rabes HM", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10439047", "url": "https://glygen.org/publication/PubMed/10439047" } ] }, { "title": "Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.", "journal": "Oncogene", "date": "1999", "authors": "Iwashita T, Kato M, Murakami H, Asai N, Ishiguro Y, Ito S, Iwata Y, Kawai K, Asai M, Kurokawa K, Kajita H, Takahashi M", "evidence": [ { "database": "iPTMnet", "id": "P07949-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949-1" } ], "reference": [ { "type": "PubMed", "id": "10445857", "url": "https://glygen.org/publication/PubMed/10445857" } ] }, { "title": "Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Murakami H, Iwashita T, Asai N, Shimono Y, Iwata Y, Kawai K, Takahashi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "10448070", "url": "https://glygen.org/publication/PubMed/10448070" } ] }, { "title": "Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site.", "journal": "Human molecular genetics", "date": "1999", "authors": "Geneste O, Bidaud C, De Vita G, Hofstra RM, Tartare-Deckert S, Buys CH, Lenoir GM, Santoro M, Billaud M", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10484767", "url": "https://glygen.org/publication/PubMed/10484767" } ] }, { "title": "Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.", "journal": "The EMBO journal", "date": "1999", "authors": "Adachi M, Fukuda M, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "10508167", "url": "https://glygen.org/publication/PubMed/10508167" } ] }, { "title": "A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1999", "authors": "Tessitore A, Sinisi AA, Pasquali D, Cardone M, Vitale D, Bellastella A, Colantuoni V", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10522989", "url": "https://glygen.org/publication/PubMed/10522989" } ] }, { "title": "A new germline mutation, R600Q, within the coding region of RET proto-oncogene: a rare polymorphism or a MEN 2 causing mutation?", "journal": "Hum. Mutat.", "date": "2000", "authors": "S\u00e1ez M E, Ruiz A, Cebri\u00e1n A, Morales F, Robledo M, Anti\u00f1olo G, Borrego S", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10612852", "url": "https://glygen.org/publication/PubMed/10612852" } ] }, { "title": "A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Bolk S, Pelet A, Hofstra RM, Angrist M, Salomon R, Croaker D, Buys CH, Lyonnet S, Chakravarti A", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10618407", "url": "https://glygen.org/publication/PubMed/10618407" } ] }, { "title": "A RET double mutation in the germline of a kindred with FMTC.", "journal": "Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association", "date": "2000", "authors": "Bartsch DK, Hasse C, Schug C, Barth P, Rothmund M, Hoppner W", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10826520", "url": "https://glygen.org/publication/PubMed/10826520" } ] }, { "title": "A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Shao H, Andres DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "10869344", "url": "https://glygen.org/publication/PubMed/10869344" } ] }, { "title": "Variable expressivity of familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-->ATG) mutation.", "journal": "Surgery", "date": "2000", "authors": "Feldman GL, Edmonds MW, Ainsworth PJ, Schuffenecker I, Lenoir GM, Saxe AW, Talpos GB, Roberson J, Petrucelli N, Jackson CE", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "10876191", "url": "https://glygen.org/publication/PubMed/10876191" } ] }, { "title": "RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.", "journal": "Oncogene", "date": "2000", "authors": "Corvi R, Berger N, Balczon R, Romeo G", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "10980597", "url": "https://glygen.org/publication/PubMed/10980597" } ] }, { "title": "Familial form of hirschsprung disease: nucleotide sequence studies reveal point mutations in the RET proto-oncogene in two of six families but not in other candidate genes.", "journal": "American journal of medical genetics", "date": "2000", "authors": "Munnes M, Fanaei S, Schmitz B, Muiznieks I, Holschneider AM, Doerfler W", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "10982477", "url": "https://glygen.org/publication/PubMed/10982477" } ] }, { "title": "Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Besset V, Scott RP, Ibanez CF", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "10995764", "url": "https://glygen.org/publication/PubMed/10995764" } ] }, { "title": "Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells.", "journal": "Molecular and cellular endocrinology", "date": "2000", "authors": "Hennige AM, Lammers R, Arlt D, Hoppner W, Strack V, Niederfellner G, Seif FJ, Haring HU, Kellerer M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "11000521", "url": "https://glygen.org/publication/PubMed/11000521" } ] }, { "title": "Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor.", "journal": "Oncogene", "date": "2000", "authors": "Hayashi H, Ichihara M, Iwashita T, Murakami H, Shimono Y, Kawai K, Kurokawa K, Murakumo Y, Imai T, Funahashi H, Nakao A, Takahashi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "11002419", "url": "https://glygen.org/publication/PubMed/11002419" } ] }, { "title": "Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Zhang S, Broxmeyer HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "11027663", "url": "https://glygen.org/publication/PubMed/11027663" } ] }, { "title": "Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2000", "authors": "Salvatore D, Barone MV, Salvatore G, Melillo RM, Chiappetta G, Mineo A, Fenzi G, Vecchio G, Fusco A, Santoro M", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" }, { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11061555", "url": "https://glygen.org/publication/PubMed/11061555" } ] }, { "title": "Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.", "journal": "Blood", "date": "2000", "authors": "Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Muller C, Gruning W, Kratz-Albers K, Serve S, Steur C, Buchner T, Kienast J, Kanakura Y, Berdel WE, Serve H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "11090077", "url": "https://glygen.org/publication/PubMed/11090077" } ] }, { "title": "Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.", "journal": "Cell", "date": "2000", "authors": "Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "11136978", "url": "https://glygen.org/publication/PubMed/11136978" } ] }, { "title": "Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Hayashi Y, Iwashita T, Murakamai H, Kato Y, Kawai K, Kurokawa K, Tohnai I, Ueda M, Takahashi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "11237712", "url": "https://glygen.org/publication/PubMed/11237712" } ] }, { "title": "Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.", "journal": "Cancer research", "date": "2001", "authors": "Salvatore D, Melillo RM, Monaco C, Visconti R, Fenzi G, Vecchio G, Fusco A, Santoro M", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11245446", "url": "https://glygen.org/publication/PubMed/11245446" } ] }, { "title": "A rare variant, I852M, of the RET proto-oncogene in a patient with medullary thyroid carcinoma at age 20 years.", "journal": "Human mutation", "date": "2001", "authors": "Demeester R, Parma J, Cochaux P, Vassart G, Abramowicz MJ", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "11295841", "url": "https://glygen.org/publication/PubMed/11295841" } ] }, { "title": "A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.", "journal": "Oncogene", "date": "2001", "authors": "Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "11313946", "url": "https://glygen.org/publication/PubMed/11313946" } ] }, { "title": "The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.", "journal": "Oncogene", "date": "2001", "authors": "Melillo RM, Carlomagno F, De Vita G, Formisano P, Vecchio G, Fusco A, Billaud M, Santoro M", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11313948", "url": "https://glygen.org/publication/PubMed/11313948" } ] }, { "title": "Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of the RET proto-oncogene demonstrating low grade malignancy.", "journal": "European journal of endocrinology", "date": "2001", "authors": "Siggelkow H, Melzer A, Nolte W, Karsten K, Hoppner W, Hufner M", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "11331212", "url": "https://glygen.org/publication/PubMed/11331212" } ] }, { "title": "CGH alterations in medullary thyroid carcinomas in relation to the RET M918T mutation and clinical outcome.", "journal": "International journal of oncology", "date": "2001", "authors": "Frisk T, Zedenius J, Lundberg J, Wallin G, Kytola S, Larsson C", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "11351254", "url": "https://glygen.org/publication/PubMed/11351254" } ] }, { "title": "Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.", "journal": "Oncogene", "date": "2001", "authors": "Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "11360177", "url": "https://glygen.org/publication/PubMed/11360177" } ] }, { "title": "Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Melillo RM, Santoro M, Ong SH, Billaud M, Fusco A, Hadari YR, Schlessinger J, Lax I", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "11390647", "url": "https://glygen.org/publication/PubMed/11390647" } ] }, { "title": "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.", "journal": "The Journal of cell biology", "date": "2001", "authors": "Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" }, { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11470823", "url": "https://glygen.org/publication/PubMed/11470823" } ] }, { "title": "Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation.", "journal": "Antioxidants & redox signaling", "date": "2001", "authors": "Takeda K, Kato M, Wu J, Iwashita T, Suzuki H, Takahashi M, Nakashima I", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "11491658", "url": "https://glygen.org/publication/PubMed/11491658" } ] }, { "title": "Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062.", "journal": "Brain research", "date": "2001", "authors": "Yamamoto M, Li M, Mitsuma N, Ito S, Kato M, Takahashi M, Sobue G", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11520496", "url": "https://glygen.org/publication/PubMed/11520496" } ] }, { "title": "MEN2A-RET-induced cellular transformation by activation of STAT3.", "journal": "Oncogene", "date": "2001-08-30", "authors": "Schuringa J J, Wojtachnio K, Hagens W, Vellenga E, Buys C H, Hofstra R, Kruijer W", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11536047", "url": "https://glygen.org/publication/PubMed/11536047" } ] }, { "title": "Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Matsubayashi Y, Fukuda M, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "11546808", "url": "https://glygen.org/publication/PubMed/11546808" } ] }, { "title": "Germline sequence variant S836S in the RET proto-oncogene is associated with low level predisposition to sporadic medullary thyroid carcinoma in the Spanish population.", "journal": "Clinical endocrinology", "date": "2001", "authors": "Ruiz A, Antinolo G, Fernandez RM, Eng C, Marcos I, Borrego S", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "11589684", "url": "https://glygen.org/publication/PubMed/11589684" } ] }, { "title": "Three novel mutations in the RET proto-oncogene.", "journal": "Journal of molecular medicine (Berlin, Germany)", "date": "2001", "authors": "Kalinin VN, Amosenko FA, Shabanov MA, Lubchenko LN, Hosch SB, Garkavtseva RF, Izbicki JR", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "11692159", "url": "https://glygen.org/publication/PubMed/11692159" } ] }, { "title": "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.", "journal": "Developmental cell", "date": "2001", "authors": "Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "11702783", "url": "https://glygen.org/publication/PubMed/11702783" } ] }, { "title": "Familial medullary thyroid carcinoma and prominent corneal nerves associated with the germline V804M and V778I mutations on the same allele of RET.", "journal": "Journal of medical genetics", "date": "2001", "authors": "Kasprzak L, Nolet S, Gaboury L, Pavia C, Villabona C, Rivera-Fillat F, Oriola J, Foulkes WD", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "11732489", "url": "https://glygen.org/publication/PubMed/11732489" } ] }, { "title": "Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Fukuda T, Kiuchi K, Takahashi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" }, { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "11886862", "url": "https://glygen.org/publication/PubMed/11886862" } ] }, { "title": "Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2002", "authors": "Lombardo F, Baudin E, Chiefari E, Arturi F, Bardet S, Caillou B, Conte C, Dallapiccola B, Giuffrida D, Bidart JM, Schlumberger M, Filetti S", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "11932300", "url": "https://glygen.org/publication/PubMed/11932300" } ] }, { "title": "Germ-line mutations in nonsyndromic pheochromocytoma.", "journal": "The New England journal of medicine", "date": "2002", "authors": "Neumann HP, Bausch B, McWhinney SR, Bender BU, Gimm O, Franke G, Schipper J, Klisch J, Altehoefer C, Zerres K, Januszewicz A, Eng C, Smith WM, Munk R, Manz T, Glaesker S, Apel TW, Treier M, Reineke M, Walz MK, Hoang-Vu C, Brauckhoff M, Klein-Franke A, Klose P, Schmidt H, Maier-Woelfle M, Peczkowska M, Szmigielski C, Eng C", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "12000816", "url": "https://glygen.org/publication/PubMed/12000816" } ] }, { "title": "V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers.", "journal": "Surgery", "date": "2002", "authors": "Lecube A, Hernandez C, Oriola J, Galard R, Gemar E, Mesa J, Simo R", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "12019403", "url": "https://glygen.org/publication/PubMed/12019403" } ] }, { "title": "ERK2 enters the nucleus by a carrier-independent mechanism.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Whitehurst AW, Wilsbacher JL, You Y, Luby-Phelps K, Moore MS, Cobb MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "12032311", "url": "https://glygen.org/publication/PubMed/12032311" } ] }, { "title": "Congenital central hypoventilation syndrome: a novel mutation of the RET gene in an isolated case.", "journal": "Tohoku J. Exp. Med.", "date": "2002", "authors": "Kanai M, Numakura C, Sasaki A, Shirahata E, Akaba K, Hashimoto M, Hasegawa H, Shirasawa S, Hayasaka K", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "12086152", "url": "https://glygen.org/publication/PubMed/12086152" } ] }, { "title": "The long and short isoforms of Ret function as independent signaling complexes.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Tsui-Pierchala BA, Ahrens RC, Crowder RJ, Milbrandt J, Johnson EM Jr", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "12091387", "url": "https://glygen.org/publication/PubMed/12091387" } ] }, { "title": "The phosphatidylinositol 3-Kinase AKT pathway in human cancer.", "journal": "Nature reviews. Cancer", "date": "2002", "authors": "Vivanco I, Sawyers CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "12094235", "url": "https://glygen.org/publication/PubMed/12094235" } ] }, { "title": "Activation of phosphoinositide 3-kinase gamma by Ras.", "journal": "Current biology : CB", "date": "2002", "authors": "Suire S, Hawkins P, Stephens L", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "12121613", "url": "https://glygen.org/publication/PubMed/12121613" } ] }, { "title": "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "12242309", "url": "https://glygen.org/publication/PubMed/12242309" } ] }, { "title": "Primary hyperparathyroidism, C-cell hyperplasia and papillary thyroid carcinoma in a patient with RET germline polymorphism S836S.", "journal": "Langenbeck's archives of surgery", "date": "2002", "authors": "Brauckhoff M, Gimm O, Bilkenroth U, Hinze R, Dralle H", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "12410354", "url": "https://glygen.org/publication/PubMed/12410354" } ] }, { "title": "A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinoma.", "journal": "American journal of human genetics", "date": "2003", "authors": "Borrego S, Wright FA, Fernandez RM, Williams N, Lopez-Alonso M, Davuluri R, Antinolo G, Eng C", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "12474140", "url": "https://glygen.org/publication/PubMed/12474140" } ] }, { "title": "Segregation of the V804L mutation and S836S polymorphism of exon 14 of the RET gene in an extended kindred with familial medullary thyroid cancer.", "journal": "Clinical genetics", "date": "2003", "authors": "Patocs A, Valkusz Z, Igaz P, Balogh K, Toth M, Varga I, Racz K", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "12694233", "url": "https://glygen.org/publication/PubMed/12694233" } ] }, { "title": "Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease.", "journal": "European journal of human genetics : EJHG", "date": "2003", "authors": "Nishikawa M, Murakumo Y, Imai T, Kawai K, Nagaya M, Funahashi H, Nakao A, Takahashi M", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "12734540", "url": "https://glygen.org/publication/PubMed/12734540" } ] }, { "title": "Penetrance of inherited medullary thyroid carcinoma and genotype-phenotype correlation in a large multiple endocrine neoplasia type 2A family with C634Y RET mutation.", "journal": "Endocrine pathology", "date": "2003", "authors": "Gonzalez-Yebra B, Medrano ME, Mantilla A, Palma V, Colin C, Hernandez DM, Tapia J, Dawson B, Salcedo M", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "12746565", "url": "https://glygen.org/publication/PubMed/12746565" } ] }, { "title": "Cell signalling and gene expression mediated by RET tyrosine kinase.", "journal": "Journal of internal medicine", "date": "2003", "authors": "Kurokawa K, Kawai K, Hashimoto M, Ito Y, Takahashi M", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "12755958", "url": "https://glygen.org/publication/PubMed/12755958" } ] }, { "title": "Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.", "journal": "Oncogene", "date": "2003", "authors": "Andreozzi F, Melillo RM, Carlomagno F, Oriente F, Miele C, Fiory F, Santopietro S, Castellone MD, Beguinot F, Santoro M, Formisano P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "12771945", "url": "https://glygen.org/publication/PubMed/12771945" } ] }, { "title": "Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.", "journal": "Mutat. 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"url": "https://www.uniprot.org/uniprot/P07949" }, { "database": "iPTMnet", "id": "P07949-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949-1" } ], "reference": [ { "type": "PubMed", "id": "14711813", "url": "https://glygen.org/publication/PubMed/14711813" } ] }, { "title": "Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Encinas M, Crowder RJ, Milbrandt J, Johnson EM Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" }, { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "14766744", "url": "https://glygen.org/publication/PubMed/14766744" } ] }, { "title": "Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.", "journal": "Oncogene", "date": "2004", "authors": "Castellone MD, Celetti A, Guarino V, Cirafici AM, Basolo F, Giannini R, Medico E, Kruhoffer M, Orntoft TF, Curcio F, Fusco A, Melillo RM, Santoro M", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "14981541", "url": "https://glygen.org/publication/PubMed/14981541" } ] }, { "title": "The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation.", "journal": "The EMBO journal", "date": "2004", "authors": "Leppanen VM, Bespalov MM, Runeberg-Roos P, Puurand U, Merits A, Saarma M, Goldman A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "15044950", "url": "https://glygen.org/publication/PubMed/15044950" } ] }, { "title": "RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2004", "authors": "Elisei R, Cosci B, Romei C, Bottici V, Sculli M, Lari R, Barale R, Pacini F, Pinchera A", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15240649", "url": "https://glygen.org/publication/PubMed/15240649" } ] }, { "title": "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "15286081", "url": 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"type": "PubMed", "id": "15345114", "url": "https://glygen.org/publication/PubMed/15345114" } ] }, { "title": "Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2004", "authors": "Arnaud M, Crouin C, Deon C, Loyaux D, Bertoglio J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "15356145", "url": "https://glygen.org/publication/PubMed/15356145" } ] }, { "title": "Nuclear localization and regulation of erk- and rsk-encoded protein kinases.", "journal": "Molecular and cellular biology", "date": "1992", "authors": "Chen RH, Sarnecki C, Blenis J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "1545823", "url": "https://glygen.org/publication/PubMed/1545823" } ] }, { "title": "Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease.", "journal": "World journal of surgery", "date": "2004", "authors": "Brauckhoff M, Gimm O, Weiss CL, Ukkat J, Sekulla C, Brauckhoff K, Thanh PN, Dralle H", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15517484", "url": "https://glygen.org/publication/PubMed/15517484" } ] }, { "title": "Emergence of medullary thyroid carcinoma in a family with the Cys630Arg RET germline mutation.", "journal": "Surgery", "date": "2004", "authors": "Machens A, Schneyer U, Holzhausen HJ, Raue F, Dralle H", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15523405", "url": "https://glygen.org/publication/PubMed/15523405" } ] }, { "title": "Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2004", "authors": "Elisei R, Cosci B, Romei C, Agate L, Piampiani P, Miccoli P, Berti P, Basolo F, Ugolini C, Ciampi R, Nikiforov Y, Pinchera A", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15531548", "url": "https://glygen.org/publication/PubMed/15531548" } ] }, { "title": "Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Burack WR, Shaw AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": 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CF", "evidence": [ { "database": "iPTMnet", "id": "P07949-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949-1" } ], "reference": [ { "type": "PubMed", "id": "15677445", "url": "https://glygen.org/publication/PubMed/15677445" } ] }, { "title": "Medullary thyroid cancer in a patient with Hirschsprung disease with a C609Y germline RET-mutation.", "journal": "Journal of pediatric gastroenterology and nutrition", "date": "2005", "authors": "de Groot JW, Sijmons RH, Links TP, Plukker JT, Hofstra RM", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15699703", "url": "https://glygen.org/publication/PubMed/15699703" } ] }, { "title": "RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.", "journal": "Cancer research", "date": "2005", "authors": "Plaza Menacho I, Koster R, van der Sloot AM, Quax WJ, Osinga J, van der Sluis T, Hollema H, Burzynski GM, Gimm O, Buys CH, Eggen BJ, Hofstra RM", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "15753368", "url": "https://glygen.org/publication/PubMed/15753368" } ] }, { "title": "Medullary thyroid carcinoma in a child with a new RET mutation and a RET polymorphism.", "journal": "Genetic counseling (Geneva, Switzerland)", "date": "2005", "authors": "Vandenbosch K, Renard M, Uyttebroeck A, Sciot R, Matthijs G, Legius E", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15844786", "url": "https://glygen.org/publication/PubMed/15844786" } ] }, { "title": "The familial medullary thyroid carcinoma-associated RET E768D mutation in a multiple endocrine neoplasia type 2A case.", "journal": "Surgery", "date": "2005", "authors": "Aiello A, Cioni K, Gobbo M, Collini P, Gullo M, Della Torre G, Passerini E, Ferrando B, Pilotti S, Pierotti MA, Pasini B", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15855933", "url": "https://glygen.org/publication/PubMed/15855933" } ] }, { "title": "[G691S, L769L and S836S ret proto-oncogene polymorphisms are not associated with higher risk to sporadic medullary thyroid carcinoma in Chilean patients].", "journal": "Revista medica de Chile", "date": "2005", "authors": "Wohllk G N, Soto C E, Bravo A M, Becker C P", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "15953945", "url": "https://glygen.org/publication/PubMed/15953945" } ] }, { "title": "Penetrance and clinical manifestations of non-hotspot germline RET mutation, C630R, in a family with medullary thyroid carcinoma.", "journal": "Thyroid : official journal of the American Thyroid Association", "date": "2005", "authors": "Dourisboure RJ, Belli S, Domenichini E, Podesta EJ, Eng C, Solano AR", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16053382", "url": "https://glygen.org/publication/PubMed/16053382" } ] }, { "title": "Polymorphisms in exon 13 and intron 14 of the RET protooncogene: genetic modifiers of medullary thyroid carcinoma?", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2005", "authors": "Baumgartner-Parzer SM, Lang R, Wagner L, Heinze G, Niederle B, Kaserer K, Waldhausl W, Vierhapper H", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16118333", "url": "https://glygen.org/publication/PubMed/16118333" } ] }, { "title": "Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma.", "journal": "Clinical endocrinology", "date": "2005", "authors": "Kinlaw WB, Scott SM, Maue RA, Memoli VA, Harris RD, Daniels GH, Porter DM, Belloni DR, Spooner ET, Ernesti MM, Noll WW", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16343103", "url": "https://glygen.org/publication/PubMed/16343103" } ] }, { "title": "The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling.", "journal": "Cancer research", "date": "2005", "authors": "Sawai H, Okada Y, Kazanjian K, Kim J, Hasan S, Hines OJ, Reber HA, Hoon DS, Eibl G", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16357163", "url": "https://glygen.org/publication/PubMed/16357163" } ] }, { "title": "Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg.", "journal": "Journal of endocrinological investigation", "date": "2005", "authors": "Dvorakova S, Vaclavikova E, Duskova J, Vlcek P, Ryska A, Bendlova B", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16419493", "url": "https://glygen.org/publication/PubMed/16419493" } ] }, { "title": "Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.", "journal": "Journal of cell science", "date": "2006-04-15", "authors": "Zhang Yong, Zhu Wei, Wang Yong-Gang, Liu Xiu-Jie, Jiao Li, Liu Xuan, Zhang Zhao-Huan, Lu Chang-Lin, He Cheng", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "16569669", "url": "https://glygen.org/publication/PubMed/16569669" } ] }, { "title": "Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.", "journal": "Blood", "date": "2006", "authors": "Rocnik JL, Okabe R, Yu JC, Lee BH, Giese N, Schenkein DP, Gilliland DG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "16627759", "url": "https://glygen.org/publication/PubMed/16627759" } ] }, { "title": "Analysis of RET polymorphisms and haplotypes in the context of sporadic medullary thyroid carcinoma.", "journal": "Thyroid : official journal of the American Thyroid Association", "date": "2006", "authors": "Fernandez RM, Pecina A, Antinolo G, Navarro E, Borrego S", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16646689", "url": "https://glygen.org/publication/PubMed/16646689" } ] }, { "title": "Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.", "journal": "Blood", "date": "2006", "authors": "Heiss E, Masson K, Sundberg C, Pedersen M, Sun J, Bengtsson S, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "16684964", "url": "https://glygen.org/publication/PubMed/16684964" } ] }, { "title": "Occurrence of the Cys611Tyr mutation and a novel Arg886Trp substitution in the RET proto-oncogene in multiple endocrine neoplasia type 2 families and sporadic medullary thyroid carcinoma cases originating from the central region of Portugal.", "journal": "Clinical endocrinology", "date": "2006", "authors": "Prazeres HJ, Rodrigues F, Figueiredo P, Naidenov P, Soares P, Bugalho MJ, Lacerda M, Campos B, Martins TC", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16712668", "url": "https://glygen.org/publication/PubMed/16712668" } ] }, { "title": "The RET mutation E768D confers a late-onset familial medullary thyroid carcinoma -- only phenotype with incomplete penetrance: implications for screening and management of carrier status.", "journal": "Familial cancer", "date": "2006", "authors": "Dabir T, Hunter SJ, Russell CF, McCall D, Morrison PJ", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "16736292", "url": "https://glygen.org/publication/PubMed/16736292" } ] }, { "title": "The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.", "journal": "Cancer Res.", "date": "2006", "authors": "Iervolino A, Iuliano R, Trapasso F, Viglietto G, Melillo RM, Carlomagno F, Santoro M, Fusco A", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "16778204", "url": "https://glygen.org/publication/PubMed/16778204" } ] }, { "title": "Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations.", "journal": "Surgery", "date": "2006", "authors": "de Groot JW, Plaza Menacho I, Schepers H, Drenth-Diephuis LJ, Osinga J, Plukker JT, Links TP, Eggen BJ, Hofstra RM", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "16782438", "url": 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"id": "16839264", "url": "https://glygen.org/publication/PubMed/16839264" } ] }, { "title": "Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Lundgren TK, Scott RP, Smith M, Pawson T, Ernfors P", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "16847065", "url": "https://glygen.org/publication/PubMed/16847065" } ] }, { "title": "Genotype-phenotype correlations in Hungarian patients with hereditary medullary thyroid cancer.", "journal": "Wiener klinische Wochenschrift", "date": "2006", "authors": "Patocs A, Klein I, Szilvasi A, Gergics P, Toth M, Valkusz Z, Forizs E, Igaz P, Al-Farhat Y, Tordai A, Varadi A, Racz K, Esik O", "evidence": [ { "database": "Entrez", "id": "5979", "url": 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Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "Association of p21ras with phosphatidylinositol 3-kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1991", "authors": "Sjolander A, Yamamoto K, Huber BE, Lapetina EG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "1716764", "url": "https://glygen.org/publication/PubMed/1716764" } ] }, { "title": "RET proto-oncogene in Sardinia: V804M is the most frequent mutation and may be associated with FMTC/MEN-2A phenotype.", "journal": "Thyroid : official journal of the American Thyroid Association", "date": "2007", "authors": "Pinna G, Orgiana G, Riola A, Ghiani M, Lai ML, Carcassi C, Mariotti S", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "17316110", "url": "https://glygen.org/publication/PubMed/17316110" } ] }, { "title": "Patterns of somatic mutation in human cancer genomes.", "journal": "Nature", "date": "2007", "authors": "Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian 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"title": "SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.", "journal": "Oncogene", "date": "2007", "authors": "Donatello S, Fiorino A, Degl'Innocenti D, Alberti L, Miranda C, Gorla L, Bongarzone I, Rizzetti MG, Pierotti MA, Borrello MG", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "17471236", "url": "https://glygen.org/publication/PubMed/17471236" } ] }, { "title": "RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface.", "journal": "Oncogene", "date": "2007", "authors": "Runeberg-Roos P, Virtanen H, Saarma M", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "17599050", "url": "https://glygen.org/publication/PubMed/17599050" } ] }, { "title": "Y791F RET mutation and early onset of 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Keuser R, Gross U, Rondot S, Raue F, Senninger N, Putzer BM, Frank-Raue K", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "18322301", "url": "https://glygen.org/publication/PubMed/18322301" } ] }, { "title": "Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?", "journal": "Clinical endocrinology", "date": "2008", "authors": "Cardot-Bauters C, Leteurtre E, Leclerc L, Vantyghem MC, Do Cao C, Wemeau JL, d'Herbomez M, Carnaille B, Barbu V, Pinson S, Pigny P", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "18331611", "url": "https://glygen.org/publication/PubMed/18331611" } ] }, { "title": "A new germline point mutation in Ret exon 8 (cys515ser) in a family with medullary thyroid carcinoma.", "journal": "Thyroid : official journal of the American Thyroid 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"title": "CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2008", "authors": "Tsui CC, Pierchala BA", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "18753381", "url": "https://glygen.org/publication/PubMed/18753381" } ] }, { "title": "Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes.", "journal": "Molecular cell", "date": "2008", "authors": "Casar B, Pinto A, Crespo P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "18775330", "url": "https://glygen.org/publication/PubMed/18775330" } ] }, { "title": "Multiple endocrine neoplasia type 2A 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Surg.", "date": "2009", "authors": "Leon Thomas Y Y, Ngan Elly S W, Poon Hiu-Ching, So Man-Ting, Lui Vincent C H, Tam Paul K H, Garcia-Barcelo Maria Mercedes", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "19853745", "url": "https://glygen.org/publication/PubMed/19853745" } ] }, { "title": "Inhibiton of RET and JAK2 signals and upregulation of VEGFR3 phosphorylation in vitro by galectin-1 in trophoblast tumor cells BeWo.", "journal": "Placenta", "date": "2009", "authors": "Fischer I, Schulze S, Kuhn C, Friese K, Walzel H, Markert UR, Jeschke U", "evidence": [ { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "19900702", "url": "https://glygen.org/publication/PubMed/19900702" } ] }, { "title": "ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Lidke DS, Huang F, Post JN, Rieger B, Wilsbacher J, Thomas JL, Pouyssegur J, Jovin TM, Lenormand P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "19920141", "url": "https://glygen.org/publication/PubMed/19920141" } ] }, { "title": "One hundred and seven family members with the rearranged during transfection V804M proto-oncogene mutation presenting with simultaneous medullary and papillary thyroid carcinomas, rare primary hyperparathyroidism, and no pheochromocytomas: is this a new syndrome--MEN 2C?", "journal": "Surgery", "date": "2009", "authors": "Shifrin AL, Xenachis C, Fay A, Matulewicz TJ, Kuo YH, Vernick JJ", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "19958926", "url": "https://glygen.org/publication/PubMed/19958926" } ] }, { "title": "New mutations in the RET protooncogene-L881V - associated with medullary thyroid carcinoma and -R770Q - in a patient with mixed medullar/follicular thyroid tumour.", "journal": "Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association", "date": "2010", "authors": "Frank-Raue K, Dohring J, Scheumann G, Rondot S, Lorenz A, Schulze E, Dralle H, Raue F, Leidig-Bruckner G", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "20013610", "url": "https://glygen.org/publication/PubMed/20013610" } ] }, { "title": "A novel de novo germ-line V292M mutation in the extracellular region of RET in a patient with phaeochromocytoma and medullary thyroid carcinoma: functional characterization.", "journal": "Clinical endocrinology", "date": "2010", "authors": "Castellone MD, Verrienti A, Magendra Rao D, Sponziello M, Fabbro D, Muthu M, Durante C, Maranghi M, Damante G, Pizzolitto S, Costante G, Russo D, Santoro M, Filetti S", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "20039896", "url": "https://glygen.org/publication/PubMed/20039896" } ] }, { "title": "RETouching upon mechanoreceptors.", "journal": "Neuron", "date": "2009-12-24", "authors": "Ma Qiufu", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "20064382", "url": "https://glygen.org/publication/PubMed/20064382" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "P07949-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.", "journal": "Bioorganic & medicinal chemistry", "date": "2010", "authors": "Mologni L, Rostagno R, Brussolo S, Knowles PP, Kjaer S, Murray-Rust J, Rosso E, Zambon A, Scapozza L, McDonald NQ, Lucchini V, Gambacorti-Passerini C", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" }, { "database": "iPTMnet", "id": "P07949", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07949" } ], "reference": [ { "type": "PubMed", "id": "20117004", "url": "https://glygen.org/publication/PubMed/20117004" } ] }, { "title": "A Korean family of familial medullary thyroid cancer with Cys618Ser RET germline mutation.", "journal": "Journal of Korean medical science", "date": "2010", "authors": "Jung J, Uchino S, Lee Y, Park H", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "20119574", "url": "https://glygen.org/publication/PubMed/20119574" } ] }, { "title": "Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold.", "journal": "Eur. 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Cancer", "date": "2010", "authors": "Vigil D, Cherfils J, Rossman KL, Der CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "21102635", "url": "https://glygen.org/publication/PubMed/21102635" } ] }, { "title": "A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo.", "journal": "Surgery", "date": "2010", "authors": "Samadi Abbas K, Mukerji Ridhwi, Shah Anuj, Timmermann Barbara N, Cohen Mark S", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "21134556", "url": "https://glygen.org/publication/PubMed/21134556" } ] }, { "title": "Single nucleotide polymorphisms act as modifiers and correlate with the development of medullary and simultaneous medullary/papillary thyroid carcinomas in 2 large, non-related families with the RET V804M proto-oncogene mutation.", "journal": "Surgery", "date": "2010", "authors": "Shifrin AL, Ogilvie JB, Stang MT, Fay AM, Kuo YH, Matulewicz T, Xenachis CZ, Vernick JJ", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "21134561", "url": "https://glygen.org/publication/PubMed/21134561" } ] }, { "title": "Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation.", "journal": "Thyroid : official journal of the American Thyroid Association", "date": "2011", "authors": "Jasim S, Ying AK, Waguespack SG, Rich TA, Grubbs EG, Jimenez C, Hu MI, Cote G, Habra MA", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "21186952", "url": "https://glygen.org/publication/PubMed/21186952" } ] }, { "title": "Indolent medullary thyroid cancer with a RET proto-oncogene Cys618Phe mutation presenting as sporadic unilateral pheochromocytoma in a 55-year-old Korean woman.", "journal": "Thyroid : official journal of the American Thyroid Association", "date": "2011", "authors": "Kim DD, Croxson MS, Cranshaw IM, Evans JL, Marquis-Nicholson R, Love DR", "evidence": [ { "database": "Entrez", "id": "5979", "url": "https://www.ncbi.nlm.nih.gov/gene/5979" } ], "reference": [ { "type": "PubMed", "id": "21254918", "url": "https://glygen.org/publication/PubMed/21254918" } ] }, { "title": "RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "21357690", "url": 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"journal": "Human mutation", "date": "1998", "authors": "Fattoruso O, Quadro L, Libroia A, Verga U, Lupoli G, Cascone E, Colantuoni V", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "reference": [ { "type": "PubMed", "id": "9452077", "url": "https://glygen.org/publication/PubMed/9452077" } ] }, { "title": "Persephin, a novel neurotrophic factor related to GDNF and neurturin.", "journal": "Neuron", "date": "1998", "authors": "Milbrandt J, de Sauvage FJ, Fahrner TJ, Baloh RH, Leitner ML, Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS, Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, Sherman D, Nishimura M, Wang LC, Vandlen R, Moffat B, Klein RD, Poulsen K, Gray C, Garces A, Johnson EM Jr, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853659" } ], "reference": [ { "type": "PubMed", "id": "9491986", "url": 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"https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "positive regulation of cell size", "id": "GO:0045793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045793", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "Peyer's patch morphogenesis", "id": "GO:0061146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061146", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "lymphocyte migration into lymphoid organs", "id": "GO:0097021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097021", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "ureteric bud development", "id": "GO:0001657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001657", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "membrane protein proteolysis", "id": "GO:0033619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033619", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "response to pain", "id": "GO:0048265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048265", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "neuron cell-cell adhesion", "id": "GO:0007158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007158", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "positive regulation of neuron maturation", "id": "GO:0014042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014042", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "neuron maturation", "id": "GO:0042551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042551", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-serine phosphorylation of STAT protein", "id": "GO:0033141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033141", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase activity", "id": "GO:0004714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004714", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "plasma membrane protein complex", "id": "GO:0098797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098797", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1092, "end_pos": 1094, "annotation": "n_glycosylation_sequon" }, { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 834, "end_pos": 836, "annotation": "n_glycosylation_sequon" }, { "start_pos": 975, "end_pos": 977, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation.", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" }, { "database": "PubMed", "id": "11061555", "url": "https://glygen.org/publication/PubMed/11061555" }, { "database": "PubMed", "id": "20117004", "url": "https://glygen.org/publication/PubMed/20117004" }, { "database": "PubMed", "id": "14711813", "url": "https://glygen.org/publication/PubMed/14711813" }, { "database": "PubMed", "id": "28846099", "url": "https://glygen.org/publication/PubMed/28846099" }, { "database": "PubMed", "id": "16928683", "url": "https://glygen.org/publication/PubMed/16928683" } ] }, { "annotation": "Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons.", "evidence": [ { "database": "UniProtKB", "id": "P07949", "url": "https://www.uniprot.org/uniprot/P07949" }, { "database": "PubMed", "id": "21357690", "url": "https://glygen.org/publication/PubMed/21357690" } ] } ], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WUD9-1", "P57760-1", "P35739-1", "F1LYY7-1", "A0A8I6GCV6-1", "Q63132-1", "Q63117-1", "Q5U2X5-1", "Q63474-1", "Q4V8A3-1", "O08680-1", "O35346-1", "P54757-1", "P54758-1", "P54759-1", "P70600-1", "Q00495-1", "Q03351-1", "Q04589-1", "P06494-1", "P09759-1", "P29321-1", "P32577-1", "Q6XUX2-1", "Q62662-1", "Q62799-1", "Q62844-1", "Q62956-1", "Q63184-1", "Q63470-1", "Q498D6-1", "Q01621-1", "Q6P6U0-1", "Q63604-1", "P09760-1", "Q01986-1", "Q62862-1", "Q63572-1", "Q07014-1", "Q4KSH7-1", "G3V9H8-1", "P15127-1", "O08775-1", "P53767-1", "Q05030-1", "P55146-1", "Q64725-1", "Q63802-1", "Q64716-1", "P09215-1", "Q62689-1", "F1LM93-1", "P36506-1", "P20786-1", "P24062-1", "Q924U5-1", "Q63272-1", "B2RYC7-1", "P41243-1", "M0RDA4-1", "Q62838-1", "Q63116-1", "A0A8I6AM23-1", "P50545-1", "P57097-1", "P97523-1", "Q91ZT1-1", "D4A7W7-1", "F1LVI0-1", "E9PSY0-1", "A0A0G2K6M9-1", "F1LSN4-1", "F1MAJ0-1", "A0A0R4J8U1-1", "A0A8I6A5T6-1", "D3ZDS3-1", "D4ADZ5-1", "F1LSG7-1", "F1LRZ0-1", "D3ZBN3-1", "F1M0N1-1", "G3V6K6-1", "D3ZD03-1", "D3ZZK3-1", "E9PT20-1", "D4A584-1", "D3ZDH4-1", "A0A8I5ZVE3-1", "A0A8I6AWX7-1", "Q4KM97-1", "Q501W1-1", "B5DFD6-1", "Q5FVG7-1", "D3ZCD0-1", "A0A8I5ZP97-1", "A0A0G2JW59-1", "B1WC09-1", "Q01134-1", "P11980-1", "G3V783-1", "D3ZJI4-1", "Q4KSH6-1", "M0R7E7-1", "Q925D6-1", "Q9UM73-1", "O15146-1", "P42679-1", "P08922-1", "P07947-1", "Q12866-1", "P00519-1", "Q07912-1", "P42684-1", "Q9UF33-1", "P10721-1", "P08069-1", "P06239-1", "P04626-1", "P51451-1", "Q06187-1", "P51813-1", "Q9UIG0-1", "P49760-1", "P49761-4", "Q9HAZ1-1", "P49759-1", "P07333-1", "Q5JZY3-1", "Q6XUX3-1", "P00533-1", "Q9Y463-1", "P29317-1", "Q9NR20-1", "Q13627-1", "P54760-1", "P41240-1", "Q16832-1", "Q15375-1", "P29323-1", "P22455-1", "P16591-1", "P29322-1", "P54756-1", "P29320-1", "Q08345-1", "Q92630-1", "P54753-1", "Q15303-1", "P21860-1", "Q14289-1", "O43781-1", "P54764-1", "P19525-1", "P21709-1", "P54762-1", "P22607-1", "P21802-1", "P52333-1", "P11362-1", "P42685-1", "P06213-1", "P14616-1", "Q05655-1", "Q08881-1", "P07332-1", "P08631-1", "P29376-1", "Q05397-1", "O60674-1", "P23458-1", "P36888-1", "P09769-1", "P06241-1", "P43405-1", "P07948-1", "P46734-1", "P45985-1", "Q02750-1", "P52564-1", "O14733-1", "Q13163-1", "Q16288-1", "P36507-1", "Q16620-1", "P08581-1", "P04629-1", "Q14680-1", "Q01974-1", "P09619-1", "P07949-1", "Q504Y2-1", "P34925-1", "P16234-1", "Q13882-1", "Q04912-1", "O43353-1", "Q06418-1", "P30530-1", "Q96KB5-1", "Q15569-1", "Q96S53-1", "Q6J9G0-1", "P42680-1", "P35916-2", "P0C1S8-1", "P17948-1", "P29597-1", "P42681-1", "P35590-1", "Q13470-1", "P33981-1", "P30291-1", "P12931-1", "P35968-1", "P43403-1", "O75716-1", "Q02763-1", "Q9H3Y6-1", "P35790-1", "P14618-1", "P24604-1", "Q9Z188-1", "P35969-1", "P52332-1", "P08923-1", "Q00342-1", "Q62120-1", "Q4JIM5-1", "P97504-1", "P42682-1", "Q60629-1", "O54967-1", "P00520-1", "P97793-1", "P16277-1", "O35491-1", "O35492-1", "O35493-1", "Q9Z277-1", "P35991-1", "P22518-1", "Q8BYG9-1", "P54754-1", "P54761-1", "Q6XUX1-1", "Q62371-1", "Q60750-1", "Q61527-1", "Q62413-1", "Q61214-1", "Q61772-1", "Q61851-1", "Q922Y0-1", "Q922K9-1", "O09127-1", "P16092-1", "Q03142-1", "P29319-1", "Q01279-1", "P70424-1", "P21803-1", "Q8CBF3-1", "P41241-1", "Q03963-1", "Q8BI55-1", "P54763-3", "P16879-1", "P09581-1", "P34152-3", "P14234-1", "P39688-1", "Q03146-1", "Q03145-1", "Q61526-1", "P70451-1", "Q5U4C9-1", "Q9QVP9-1", "Q03137-1", "Q60751-1", "Q62137-1", "P28867-1", "P25911-1", "P48025-1", "Q9WTL4-1", "P41242-1", "P05532-1", "P06240-1", "P08103-1", "P15208-1", "Q03526-1", "Q9WVS7-1", "P70236-1", "P31938-1", "P47809-1", "Q61846-1", "Q60805-1", "Q63932-1", "O09110-1", "P26618-1", "Q8CE90-1", "P16056-1", "P05622-1", "P15209-1", "Q6VNS1-1", "Q61006-1", "Q3UFB7-1", "Q5RJI4-1", "Q9JJ78-1", "P58801-1", "Q8VCT9-1", "O70146-1", "Q62190-1", "Q62270-1", "P35546-1", "P35761-1", "Q9Z138-1", "Q9R117-1", "O88697-1", "P05480-2", "Q01887-1", "Q02858-1", "Q06806-1", "Q00993-1", "Q64434-1", "Q6J9G1-1", "Q99ML2-1", "Q78DX7-1", "P55144-1", "P43404-1", "P35917-1", "P47810-1", "P35918-1", "Q04736-1", "Q66JT0-1", "O54804-1", "P52480-1", "P14680-1", "P21965-1", "P22216-1", "P32490-1", "P06784-1", "P08018-1", "P32350-1", "P32491-1", "P54199-1", "Q54G28-1", "Q54N73-1", "Q54R58-1", "P18160-1", "P18161-1", "Q54BC9-1", "Q54I36-1", "Q54QV3-1", "Q552C6-1", "Q55CL6-1", "Q75JK0-1", "Q76NV1-1", "Q23977-1", "P18475-1", "P13368-1", "Q24145-1", "Q24488-1", "Q27324-1", "P08630-1", "P00522-1", "P00528-1", "P04412-1", "Q9V422-1", "Q9V6K3-1", "Q9V9J3-1", "Q9VBW3-1", "P09208-1", "P49762-1", "P83102-1", "Q24324-1", "Q9VPC0-1", "P49657-1", "P54350-1", "P18106-4", "Q07407-1", "Q09147-1", "Q24592-1", "Q9I7F7-1", "Q9V3D5-1", "Q9VZI2-1", "Q8INJ8-1", "Q7KJ08-1", "Q9VJ04-1", "E1JHB7-1", "Q9VE06-1", "O61444-1", "O62602-1", "Q9VZA8-1", "Q7KT06-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-HSA-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "equation": "", "summary": "The human genome is predicted to encode 27 RAS guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP on membrane-associated RAS in response to RAS-MAPK pathway activation by growth factors, hormones, cytokines and other stimuli (reviewed in Cherfils and Zeghouf, 2013; Cargnello and Roux, 2011). Nucleotide exchange stimulates a conformational change in RAS to facilitate its interaction with RAF, ultimately promoting the phosphorylation of downstream effectors MAPK3 and MAPK1 (also known as ERK1 and ERK2) (reviewed in Cseh et al, 2014; Vigil et al, 2010).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P01111-1", "P07949-1", "P22455-1", "P52333-1", "P16234-1", "O60674-1", "Q9UQM7-1", "P00533-1", "P04626-1", "P06241-1", "P10721-1", "Q13554-1", "Q02763-1", "P01112-1", "P36888-1", "P09619-1", "P18433-5", "Q05397-1", "Q13557-1", "P08581-1", "P23458-1", "Q13555-1" ], "evidence": [ { "id": "R-HSA-5672965", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672965" } ] }, { "id": "R-HSA-8853734", "name": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1", "equation": "", "summary": "RET has been shown to bind GRB2 indirectly via SHC (Ohiwa et al. 1997). GRB2 is found in a complex with SOS1 in unstimulated cells (Hayashi et al. 2000).

GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). This suggests that at least two distinct RET-SHC protein complexes can assemble via phosphorylated Tyrosine (Y) 1062, one involving GRB2:SOS1 leads to activation of the Ras/Erk pathway, another involving GRB1/2, GAB2 and PI3K leads to the PI3K/Akt pathway. This latter complex can also assemble directly onto phosphorylated Y1096 (Besset et al. 2000).

RET can activate the RAS-RAF-ERK signaling pathway (van Weering et al. 1995, Ohiwa et al. 1997, van Weering & Bos 1997, Trupp et al. 1999, Hayashi et al. 2000). RAS signaling is markedly impaired by mutations of RET Y1062 (Hayashi et al. 2000). RET RAS signaling and the effect of the Y1062 mutation are believed to be mediated by RET complexes involving GRB2:SOS, well known as mediators of signaling to RAS in other receptor systems (Ravichandran 2001).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853734", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853734" } ] }, { "id": "R-HSA-8853737", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1", "equation": "", "summary": "GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). RET binds SHC1 via phosphorylated tyrosine-1062 (Asai et al. 1996, Arighi et al. 1997).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853737", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853737" } ] }, { "id": "R-HSA-8853745", "name": "RET binds GFRA1,GFRA3", "equation": "", "summary": "RET is a receptor tyrosine kinase with a cadherin-related motif and a cysteine-rich domain in the extracellular domain (Takahashi et al. 1988). It is the receptor for members of the glial cell-derived neurotrophic factor (GDNF) family of ligands (Lin et al. 1993, Kotzbauer et al. 1996, Baloh et al. 1998, Milbrandt et al. 1998). RET can only bind these ligands in the presence of a co-receptor from the family of glycosylphosphatidylinositol (GPI)-anchored co-receptors collectively termed GDNF family receptor-alpha (GFRA) (Treanor et al. 1996, Jing et al. 1996, Plaza-Menacho et al. 2006). Early models proposed that GDNF formed a complex with GFRA1 and subsequently recruited RET (Massagu\u00e9 et al. 1996). Current models suggest that GFRA and RET pre-associate before ligand binding, based on binding and site-directed mutagenesis studies (Eketj\u00e4ll et al. 1999, Cik et al. 2000). An alternative model suggests that GPI-anchored GFRA recruits RET to lipid rafts after GDNF stimulation (Tansey et al. 2000). The stoichiometry as well as the kinetics of ligand-receptor complex formation are not well understood. It is believed that all GDNF family members interact with their cognate co-receptor and activate RET in a similar manner to GDNF (Airaksinen & Saarma 2002).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853745" } ] }, { "id": "R-HSA-8853753", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10", "equation": "", "summary": "Tyrosine-phosphorylated RET can bind GRB7 or GRB10 via tyrosine-905 (Pandey et al. 1995, 1996).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853753", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853753" } ] }, { "id": "R-HSA-8853755", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1", "equation": "", "summary": "Phosphorylated RET binds Phospholipase C gamma 1 (PLCG1) via tyrosine 905 (Borello et al. 1996) and/or tyrosine-1015 (Lundgren et al. 2012).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1", "P19174-1" ], "evidence": [ { "id": "R-HSA-8853755", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853755" } ] }, { "id": "R-HSA-8853762", "name": "RET dimerizes", "equation": "", "summary": "It is widely accepted that RET undergoes dimerization and transphosphorylation following Glial cell line-derived neurotrophic factor (GDNF) binding to the GDNF-family receptor:RET complex. Transphosphorylation of specific tyrosine residues is a prerequisite for activation of RET tyrosine kinase activity and downstream signaling (Santoro et al. 1995, Airaksinen et al. 1999, Takeda et al. 2001, Lepp\u00e4nen et al. 2004). However, self-association of RET in the absence of GDNF has been reported and may contribute to the mechanism of RET activation (Kjaer et al. 2006). The stoichiometry and kinetics of ligand-receptor complex formation are not well understood. It is assumed that all GDNF family of ligands (GFL) members interact with their cognate co-receptor and activate RET in a similar manner to GDNF (Airaksinen & Saarma 2002).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853762", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853762" } ] }, { "id": "R-HSA-8853774", "name": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated", "equation": "", "summary": "Grb2-associated-binder (GAB) family signaling is mediated by tyrosine phosphorylation. GAB1-3 all have an N-terminal pleckstrin homology (PH) domain, proline-rich motifs, and multiple potential tyrosyl and seryl/threonyl phosphorylation sites (Gu & Neel 2003, Liu & Rohrschneider 2002). GAB2 has several docking sites for SH2 domain-containing molecules, including tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) and the p85 subunit of phosphatidylinositol 3-kinase (p85-PI3K) (Ding et al. 2015). Similarly, GAB1 associates with PTPN11 and p85-PI3K; these interactions are considered essential for GAB1 activation of extracellular signal-regulated kinase (ERK)1/2 and PI3K-AKT, respectively (Wang et al. 2015).

GAB2 has three tyrosine (Y) residues, Y452, Y476 and Y584, that are binding sites for p85-PI3K (Crouin et al. 2001, Maus et al. 2009) and two more (Y614 and Y643) that interact with the SH2 domains of PTPN11 (Gu et al. 1998, Crouin et al. 2001, Arnaud et al. 2004). GAB1 also becomes tyrosine phosphorylated when transducing signals from receptor tyrosine kinases to p85 (Holgado-Madruga et al. 1997, Mattoon et al. 2004). There are three potential binding sites for p85 on GAB1 (Y447, Y472, and Y589) (Holgado-Madruga et al. 1997). GAB1 Y627 and Y659 appear to link it to PTPN11; GAB1 mutants that are unable to bind PTPN11 do not activate ERK (Schaeper et al. 2000, Cunnick et al. 2000, S\u00e1rmay et al. 2006).

PI3K activation produces membrane-associated PI(3,4,5)P3, which facilitates membrane association of the PH domain of GAB, enhancing its recruitment (Zhang et al. 2009) in a positive feed-back loop. The kinases responsible for GAB phosphorylation are cell-type and receptor specific (Maus et al. 2009).

GDNF stimulation of neuronal cells induces the assembly of a complex containing RET, GRB2 and tyrosine-phosphorylated SHC, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and PTPN11 (SHP2) (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). The likely order of recruitment to RET is SHC, GRB2, GAB1/2, p85 and/or PTPN11, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and others (Adams et al. 2012, Ding et al. 2015). It is likely, though not demonstrated, that GAB1/2 become tyrosine phosphorylated after binding GRB2 in the RET receptor complex. The kinase responsible is unclear. As the order of GAB binding and phosphorylation, and the identity of the kinase responsible for GAB phosphorylation have not been demonstrated, GAB phosphorylation in the RET complex is shown as an uncertain event.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853774", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853774" } ] }, { "id": "R-HSA-8853789", "name": "GDNF,NRTN bind RET:GFRA1,GFRA2", "equation": "", "summary": "Glial cell-derived neurotrophic factor (GDNF) (Lin et al. 1993) and neurturin (NRTN) (Kotzbauer et al. 1996) are ligands for GDNF family receptor-alpha (GFRA) 1 and 2 (Jing et al. 1996, 1997, Creedon et al. 1997, Baloh et al. 1997). Despite the cross activation in vitro, GDNF preferentially acts through RET:GFRA1 (Schuchardt et al. 1994, Moore et al. 1996, Pichel et al. 1996, Sanchez et al. 1996, Calcano et al. 1998, Endomoto et al. 1998, whereas NRTN preferentially acts through RET: GFRA2 (Heuckeroth et al. 1999, Rossi et al. 1999, Luo et al. 2004, 2009, Lindfors et al. 2006) in vivo.", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853789", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853789" } ] }, { "id": "R-HSA-8853792", "name": "RET tyrosine phosphorylation", "equation": "", "summary": "RET undergoes trans-autophosphorylation on specific tyrosine (Y) residues. The short and medium-length isoforms of RET contain 16 tyrosine residues; 10 in the kinase domain, 2 in the juxtamembrane domain, 1 in the kinase insert and 3 in the carboxy-terminal tail. The long RET isoform has 2 additional tyrosines in the carboxy-terminal tail. Phosphorylation of Y905 stabilizes the active conformation of the kinase and facilitates the autophosphorylation of Y residues mainly located in the C-terminal tail (Iwashita et al. 1996, Kawamoto et 2004). Y905, 1015, 1062 and 1096 are binding sites for GRB7/GRB10, phospholipase Cgamma (PLCG1), SHC1 and GRB2, respectively (Ichihara et al. 2004, Murakumo et al. 2006). Y1096 is present only in the long isoform. Phosphorylated Y981 is reported to bind SRC (Encinas et al. 2004).

RET can activate various signaling pathways including RAS-RAF-ERK (van Weering et al. 1995, Ohiwa et al. 1997, van Weering & Bos 1997, Trupp et al. 1999, Hayashi et al. 2000), phosphatidylinositol 3-kinase (PI3K)/AKT (Murakami et al. 1999a, Murakami et al. 1999b, Trupp et al. 1999, Soler et al. 1999, Segouffin-Cariou & Billaud 2000, Hayashi et al. 2000), p38 mitogen-activated protein kinase (MAPK) (Worby et al. 1996, Feng et al. 1999) and c-Jun N-terminal kinase (JNK) pathways (Xing et al. 1998, Chiariello et al. 1998). All these pathways are activated mainly through Y1062 (Hayashi et al. 2000). Point mutations at Y1062 result in a severe loss-of-function phenotype (Ib\u00e1\u00f1ez 2013). SHC1 further associates with GRB2 and GAB1/GAB2, all of which become tyrosine phosphorylated. Tyrosine-phosphorylated GAB1/2 associates with the p85 subunit of PI3K, resulting in PI3K and AKT activation (Murakami et al. 1999b, Hayashi et al. 2000, Besset et al. 2000). GRB2-GAB1/2 can also assemble directly onto phosphorylated Y1096, an alternative route to PI3K activation (Besset et al. 2000). SHC1 can also form a complex with GRB2:SOS leading to activation of the RAS-RAF-ERK pathway (Hayashi et al. 2000). However, mutation of Y1062 did not completely abolish activation of the RAS-RAF-ERK and PI3K-AKT pathways suggesting alternative signaling pathways (Ichihara et al. 2004). The adaptor protein FRS2 can bind phosphorylated Y1062 (Kurokawa et al. 2001, Melillo et al. 2001), competing with SHC1 (Lundgren et al. 2006). Differential signaling may be mediated by different compartments in the plasma membrane, as RET has been shown to interact with FRS2 in lipid rafts, but with SHC1 outside lipid rafts (Paratcha et al. 2001).

Many other proteins have been shown to bind and/or become activated via Y1062. Docking protein 1 (DOK1), 2, 4, 5, and 6 adaptor proteins all interact with phosphorylated Y1062 (Grimm et al. 2001; Crowder et al. 2004; Kurotsuchi et al. 2010). Other suggested RET interactors include Mitogen-activated protein kinase 7 (MAPK7, BMK1) (Hayashi et al. 2001), SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) (Schuetz et al. 2004), Insulin receptor substrate-2 (IRS2) (Hennige et al. 2000), SHC-transforming protein 3 (SHC3) (Pelicci et al. 2002), Protein kinase C alpha (PKCA) (Andreozzi et al. 2003) and PDZ and LIM domain protein 7 (Enigma, PDLIM7) (Durick et al. 1996). PDLIM7 and SHANK3 bind Y1062 regardless of its phosphorylation state.


Rap1GAP can bind phosphorylated Y981 to suppress GDNF-induced activation of ERK and neurite outgrowth (Jiao et al. 2011).

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP2) binds to phosphorylated Y687 and components of the Y1062 associated signaling complex, contributing to activation of PI3K/AKT and promoting survival and neurite outgrowth in primary neurons (Besset et al. 2000, Perrinjaquet et al. 2010).

It is unclear how RET activates the p38MAPK, JNK, and ERK5 signaling pathways (Ichihara et al. 2004). To simplify the representation of RET signaling, all RET tyrosines known to be involved in signalling are phosphorylated in this event.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853792" } ] }, { "id": "R-HSA-8853793", "name": "p-5Y-RET complexes bind GRB2", "equation": "", "summary": "GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000), and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). This contrasts with reports in other systems where GAB2-GRB2 were reported to constitutively associate (Gu et al. 1998). The likely order of recruitment to RET is SHC1, GRB2, GAB1/2, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and many others (Adams et al. 2012).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853793", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853793" } ] }, { "id": "R-HSA-8853800", "name": "ARTN binds RET:GFRA1,GFRA3", "equation": "", "summary": "Artemin (ARTN) is a ligand for GDNF family receptor-alpha (GFRA) 1 and 3, preferentially binding GFRA3 (Baloh et al. 1998).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853800", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853800" } ] }, { "id": "R-HSA-8853801", "name": "PSPN binds RET:GFRA4", "equation": "", "summary": "Persephin (PSPN) is a ligand for GDNF family receptor-alpha (GFRA) 4 (Milbrandt et al. 1998, Masure et al. 2000).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8853801", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853801" } ] }, { "id": "R-HSA-8854897", "name": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2", "equation": "", "summary": "Grb-associated binder (GAB) proteins are a family of docking proteins that transduce cellular signals between receptors and intracellular downstream effectors (Ding et al. 2015). When phosphorylated by protein-tyrosine kinases, GABs can recruit several Src homology-2 (SH2) domain-containing proteins, including Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP2), the p85 subunit of phosphoinositide-3 kinase (p85-PI3K), phospholipase C-gamma 1 (PLCG1), CRK and GAB-associated Cdc42/Rac GTPase-activating protein (ARHGAP32, GC-GAP). These interactions lead to various downstream signals involved in cell growth, differentiation, migration and apoptosis.

GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85-PI3K, GAB2 (GAB1 in Hayashi et al. 2000) and PTPN11 (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). This contrasts with reports that GAB2 constitutively associates with GRB2 (Gu et al. 1998).

The likely order of recruitment to RET is SHC1, GRB2, GAB1/2, p85-PI3K, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and many others (Adams et al. 2012, Ding et al. 2015). As the order of RET complex formation is not firmly established, GAB binding is shown as an uncertain event.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8854897", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8854897" } ] }, { "id": "R-HSA-8854899", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1", "equation": "", "summary": "RET has been shown to bind GRB2 directly, via Tyrosine-1096 (Y1096) (Alberti et al. 1998, Besset et al. 2000). GRB2 is found in a complex with SOS1 in unstimulated cells (Hayashi et al. 2000).

GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). This suggests that at least two distinct RET-SHC1 protein complexes can assemble via phosphorylated Y1062, one involving GRB2 and SOS1 leads to activation of the RAS-RAF-ERK pathway, another involving GRB2, GAB2 and p85 leads to the PI3K-AKT pathway. This latter complex can also assemble directly onto phosphorylated Y1096 (Besset et al. 2000).

RET can activate the RAS-RAF-ERK signaling pathway (van Weering et al. 1995, Ohiwa et al. 1997, van Weering & Bos 1997, Trupp et al. 1999, Hayashi et al. 2000). RAS signaling is markedly impaired by mutations of RET Y1062 (Hayashi et al. 2000). RET RAS signaling and the effect of the Y1062 mutation are believed to be mediated by RET complexes involving GRB2:SOS1, well known as mediators of signaling to RAS in other receptor systems (Ravichandran 2001).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8854899", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8854899" } ] }, { "id": "R-HSA-8854905", "name": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K", "equation": "", "summary": "Following recruitment and phosphorylation of GAB1 or GAB2 to the RET complex, it binds the p85 subunit of p85-containing PI3 kinase (p85-PI3K), resulting in its activation (Murakami et al. 1999, Hayashi et al. 2000, Besset et al. 2000). p85-PI3K consists of a p85 adaptor subunit, which contains one Src homology 3 (SH3) and two Src homology 2 (SH2) domains, and a p110 subunit that has catalytic activity (Kapeller & Cantley 1994). These subunits are tightly associated (Carpenter et al. 1990). Though p85-PI3K can be phosphorylated, it is binding of the p85 SH2 domains that activates the enzyme (Rordorf-Nikolic et al. 1995).

GAB2 has three tyrosine residues, Y452, Y476 and Y584, which are involved in p85-PI3K binding (Crouin et al. 2001, Maus et al. 2009). GAB1 also becomes tyrosine phosphorylated and directly associates with p85 when transducing signals from receptor tyrosine kinases to p85 (Holgado-Madruga et al. 1997, Mattoon et al. 2004). There are three potential binding sites for p85 on GAB1 (Y447, Y472, and Y589) (Holgado-Madruga et al. 1997). Phosphorylation at these sites in GAB1 is represented in this reaction as a likely prerequisite for p85 binding, but this is not experimentally confirmed, hence this reaction is displayed as an uncertain event.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1", "P42336-1", "P42338-1", "O00329-1" ], "evidence": [ { "id": "R-HSA-8854905", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8854905" } ] }, { "id": "R-HSA-8854908", "name": "PKA phosphorylates RET:GDNF:GFRA dimer", "equation": "", "summary": "Serine (S) 696 in RET is phosphorylated by protein kinase A. Mutation of this serine almost completely inhibits the ability of RET to activate the small GTPase Rac1 and stimulate formation of cell lamellipodia (Fukuda et al. 2002). Homozygous knock-in mice carrying this mutation lacked enteric neurons in the distal colon, resulting from a migration defect of enteric neural crest cells (Asai et al. 2006). The effects of the S696 RET mutant could be alleviated by simultaneous mutation of Tyrosine-687 (Fukuda et al. 2002). Activation of PKA by forskolin was found to impair the recruitment of SHP2 to RET and negatively affect ligand-mediated neurite outgrowth (Perrinjaquet et al. 2010). Mutation of S696 enhanced SHP2 binding and eliminated the effect of forskolin on ligand-induced neurite outgrowth.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1", "P22612-1", "P17612-1", "P22694-1" ], "evidence": [ { "id": "R-HSA-8854908", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8854908" } ] }, { "id": "R-HSA-8854981", "name": "SHC1 in the RET complex is phosphorylated", "equation": "", "summary": "GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000), and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). Based on the mechanism of SHC1 activation in other receptor systems (Gu et al. 2000) it is likely that SHC1 tyrosine (Y) phosphorylation occurs as a consequence of RET binding and is required for subsequent events. GRB2 binding to SHC1 requires phosphorylation of Y349, Y350 and/or Y427 (Gu et al. 2000). Mutation of RET Y1062, which binds SHC1 to initiate recruitment of GRB2-GAB-p85, did not completely abolish the activation of RAS-RAF-ERK and PI3K-AKT (Besset et al. 2000), suggesting there are alternative pathways that do not utilize SHC1. RET has been shown to bind GRB2 directly, via Y1096 (Alberti et al. 1998, Besset et al. 2000).

It has not been established whether SHC1 associates with RET in phosphorylated form or is phosphorylated after binding, and the identity of the kinase is unknown, hence this is represented as an uncertain event.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8854981", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8854981" } ] }, { "id": "R-HSA-8855508", "name": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11", "equation": "", "summary": "GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of PI3K, GAB2 (GAB1 in Hayashi et al. 2000), and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000).

PTPN11 is recruited to RET via a combination of direct interactions and indirect interactions with other components of the receptor complex such as FRS2A and GAB1/2 (Perrinjaquet et al. 2010, Willecke et al. 2011). Binding of PTPN11 SH2-domains induces a conversion of the closed inactive into an open active structure (Willecke et al. 2011).

GAB2 interacts with the SH2 domains of PTPN11 (Gu et al. 1998, Crouin et al. 2001, Arnaud et al. 2004), which binds GAB2 Tyrosine (Y) 614 and Y643 through its N- and C-terminal SH2 domains respectively. Mutation of Y614 is sufficient to prevent GAB2 from recruiting PTPN11. In the Interleukin-2 receptor system, this prevents ERK (extracellular-signal-regulated kinase) activation (Arnaud et al. 2004). Similarly, phosphorylated GAB1 binds PTPN11, PI3K, PLCgamma1 and SHC1 in activated B cells (Ingham et al. 1998). GAB1 Y627 and Y659 appear to link it to PTPN11; GAB1 mutants that are unable to bind PTPN11 do not activate ERK (Schaeper et al. 2000, Cunnick et al. 2000, S\u00e1rmay et al. 2006).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-8855508", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8855508" } ] }, { "id": "R-HSA-8855564", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2", "equation": "", "summary": "RET can bind FRS2, via phosphotyrosine-1062 (p-Y1062) (Kurokawa et al. 2001, Meillo et al. 2001). FRS2 competes with SHC1 for p-Y1062 binding (Lundgren et al. 2006). RET has been reported to associate with FRS2, instead of SHC1, when associated with lipid rafts (Paratcha et al. 2001).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8855564", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8855564" } ] }, { "id": "R-HSA-8855617", "name": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6", "equation": "", "summary": "Docking protein 1 (DOK 1), 2, 4, 5, and 6 adaptor proteins all interact with RET at phosphorylated tyrosine-1062 (Y1062) (Grimm et al. 2001, Crowder et al. 2004, Kurotsuchi et al. 2010).

DOKs are adaptor proteins that can inhibit mitogen-activated protein kinase (MAPK) signaling, cell proliferation, and cellular transformation. DOK1 and 2 may exert their inhibitory effects by recruiting Ras GTPase-activating protein 1 (RASA1, RasGAP), which is a negative regulator of Ras signaling, but DOK2 can attenuate EGF receptor-induced MAP kinase activation without RASA1. DOK3 negatively regulates signaling by recruiting INPP5D and CSK (Grimm et al. 2001).

RET promotes neurite outgrowth of the rat pheochromocytoma cell line PC12 via Y1062. RET-DOK4/5 fusion proteins induced ligand-dependent axonal outgrowth of PC12 cells, while RET-DOK2 fusions did not. DOK4/5 do not associate with RASA1 or NCK, and enhance RET-dependent activation of MAPK (Grimm et al. 2001).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8855617", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8855617" } ] }, { "id": "R-HSA-8855747", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP", "equation": "", "summary": "RET phospho-Tyr981 binds the cytoplasmic tyrosine kinase SRC (Encinas et al. 2004). Recently, a yeast-two-hybrid screen led to the identification of the GTPase-activating protein (GAP) for Rap1, RAP1GAP, as a novel RET-binding protein (Jiao et al. 2011). Like SRC, Rap1GAP was also found to require phosphorylation of Tyrosine-981 for RET binding and suppressed GDNF-induced activation of ERK and neurite outgrowth.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8855747", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8855747" } ] }, { "id": "R-HSA-8855915", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors", "equation": "", "summary": "Other RET interactors that may have a role in RET signaling include Mitogen-activated protein kinase 7 (MAPK7, BMK1) (Hayashi et al. 2001), SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) (Schuetz et al. 2004), Insulin receptor substrate-2 (IRS2) (Hennige et al. 2000), SHC-transforming protein 3 (SHC3) (Pelicci et al. 2002), Protein kinase C alpha (PKCA) (Andreozzi et al. 2003) and PDZ and LIM domain protein 7 (Enigma, PDLIM7) (Durick et al. 1996). PDLIM7 and SHANK3 bind Tyrosine-1062 regardless of its phosphorylation state.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1", "Q13164-1", "P17252-1" ], "evidence": [ { "id": "R-HSA-8855915", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8855915" } ] }, { "id": "R-HSA-8871226", "name": "RET binds GFRA1,GFRA2", "equation": "", "summary": "RET is a receptor tyrosine kinase with a cadherin-related motif and a cysteine-rich domain in the extracellular domain (Takahashi et al. 1988). It is the receptor for members of the glial cell-derived neurotrophic factor (GDNF) family of ligands (Lin et al. 1993, Kotzbauer et al. 1996, Baloh et al. 1998, Milbrandt et al. 1998). RET can only bind these ligands in the presence of a co-receptor from the family of glycosylphosphatidylinositol (GPI)-anchored co-receptors collectively termed GDNF family receptor-alpha (GFRA) (Treanor et al. 1996, Jing et al. 1996, Plaza-Menacho et al. 2006). Earlier models proposed that GDNF formed a complex with GFRA1 and subsequently recruited RET (Massagu\u00e9 et al. 1996). Current models suggest that GFRA and RET preassociate before ligand binding, based on binding and site-directed mutagenesis studies (Eketj\u00e4ll et al. 1999, Cik et al. 2000). An alternative model suggests that GPI-anchored GFRA recruits RET to lipid rafts after GDNF stimulation (Tansey et al. 2000). The stoichiometry as well as the kinetics of ligand-receptor complex formation are not well understood. It is believed that all GDNF family members interact with their cognate co-receptor and activate RET in a similar manner to GDNF (Airaksinen & Saarma 2002).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8871226", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8871226" } ] }, { "id": "R-HSA-8871227", "name": "RET binds GFRA4", "equation": "", "summary": "RET is a receptor tyrosine kinase with a cadherin-related motif and a cysteine-rich domain in the extracellular domain (Takahashi et al. 1988). It is the receptor for members of the glial cell-derived neurotrophic factor (GDNF) family of ligands (Lin et al. 1993, Kotzbauer et al. 1996, Baloh et al. 1998, Milbrandt et al. 1998). RET can only bind these ligands in the presence of a co-receptor from the family of glycosylphosphatidylinositol (GPI)-anchored co-receptors collectively termed GDNF family receptor-alpha (GFRA) (Treanor et al. 1996, Jing et al. 1996, Plaza-Menacho et al. 2006). Early models proposed that GDNF formed a complex with GFRA1 and subsequently recruited RET (Massagu\u00e9 et al. 1996). Current models suggest that GFRA and RET preassociate before ligand binding, based on binding and site-directed mutagenesis studies (Eketj\u00e4ll et al. 1999, Cik et al. 2000). An alternative model suggests that GPI-anchored GFRA recruits RET to lipid rafts after GDNF stimulation (Tansey et al. 2000). The stoichiometry as well as the kinetics of ligand-receptor complex formation are not well understood. It is believed that all GDNF family members interact with their cognate co-receptor and activate RET in a similar manner to GDNF (Airaksinen & Saarma 2002).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-8871227", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8871227" } ] }, { "id": "R-HSA-9769418", "name": "NPAS4 stimulates RET gene expression", "equation": "", "summary": "NPAS4 directly stimulates RET gene expression (Sribudiani et al. 2011). In rat primary neurons, Ret gene was also found to be significantly upregulated by Npas4 (Brigidi et al. 2019).", "cellular_location": "nucleoplasm, plasma membrane", "input_participant_list": [ "R-HSA-9770505" ], "output_participant_list": [ "R-HSA-8853797" ], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-9769418", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9769418" } ] }, { "id": "R-HSA-9830480", "name": "Expression of RET in the nephric duct", "equation": "", "summary": "The RET gene encodes a receptor tyrosine kinase that is expressed in nephric duct cells and displayed on the plasma membrane (inferred from mouse embryos). RET on the nephric duct interacts with GDNF secreted by the metanephric mesenchyme to regulate formation of the ureteric bud. Expression of RET is activated in the nephric duct by the transcription factors GATA3 (inferred from mouse homologs in Grote et al. 2006, Grote et al. 2008, Chia et al. 2011) and EMX2 (inferred from mouse homologs in Miyamoto et al. 1997) and the morphogen retinoic acid produced by the retinal dehydrogenase ALDH1A2 (also called RALDH2) (inferred from mouse homologs in Chia et al. 2011). In mouse organoids produced from cultured ureteric bud cells, enforced expression of Ret causes cells to cluster and form new ureteric buds (Packard et al. 2021).", "cellular_location": "nucleoplasm, plasma membrane", "input_participant_list": [ "R-HSA-9830379" ], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-9830480", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9830480" } ] }, { "id": "R-HSA-9830754", "name": "GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct", "equation": "", "summary": "Glial cell line-derived factor (GDNF) binds the RET recpeptor tyrosine kinase and the GFRA1 coreceptor, causing phosphorylation and activation of RET (inferred from mouse homologs, reviewed in Kawai and Takahashi et al. 2020). GDNF is secreted by the metanephric mesenchyme and interacts with RET on the nephric duct (inferred from mouse homologs). The interaction between GDNF and RET is required for formation of the ureteric bud by the nephric duct in response to contact with the metanephric mesenchyme (inferred from mouse embryos).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-9830754", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9830754" } ] }, { "id": "R-HSA-9830762", "name": "Expression of WNT11 in the nephric duct", "equation": "", "summary": "WNT11 is expressed by the nephric duct and GDNF is produced by the metanephric mesenchyme (inferred from mouse homologs). They reciprocally regulate each other to produce balanced signaling that matches production of ureteric epithelium with metanephric mesenchyme during formation of the ureteric bud (inferred from mouse homologs).", "cellular_location": "extracellular region, nucleoplasm", "input_participant_list": [ "R-HSA-9830748" ], "output_participant_list": [ "R-HSA-3247797" ], "enzyme_list": [ "P07949-1" ], "evidence": [ { "id": "R-HSA-9830762", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9830762" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-3247797", "participant_name": "N4GlycoAsn-PalmS WNT11 [extracellular region]", "crossref": [ { "id": "ENSG00000085741", "database": "OpenTargets", "url": "" }, { "id": "NP_004617.2", "database": "RefSeq", "url": "" }, { "id": "XP_005274288.1", "database": "RefSeq", "url": "" }, { "id": "O96014", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000085741", "database": "Ensembl", "url": "" }, { "id": "O96014", "database": "UniProt", "url": "" }, { "id": "O96014", "database": "GeneCards", "url": "" }, { "id": "ENST00000322563", "database": "Ensembl", "url": "" }, { "id": "O96014", "database": "PRO", "url": "" }, { "id": "ENSG00000085741-WNT11", "database": "HPA", "url": "" }, { "id": "ENSP00000325526", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-HSA-8853797", "participant_name": "RET [plasma membrane]", "crossref": [ { "id": "15200", "database": "Orphanet", "url": "" }, { "id": "ENSP00000344798", "database": "Ensembl", "url": "" }, { "id": "6Q2S", "database": "PDB", "url": "" }, { "id": "2185", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "NP_065681.1", "database": "RefSeq", "url": "" }, { "id": "6VHG", "database": "PDB", "url": "" }, { "id": "7JU6", "database": "PDB", "url": "" }, { "id": "HMDBP01526", "database": "HMDB Protein", "url": "" }, { "id": "RET_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "2X2L", "database": "PDB", "url": "" }, { "id": "P07949", "database": "GeneCards", "url": "" }, { "id": "4CKI", "database": "PDB", "url": "" }, { "id": "7RUN", "database": "PDB", "url": "" }, { "id": "6NJA", "database": "PDB", "url": "" }, { "id": "4UX8", "database": "PDB", "url": "" }, { "id": "ENST00000340058", "database": "Ensembl", "url": "" }, { "id": "6Q2N", "database": "PDB", "url": "" }, { "id": "2IVS", "database": "PDB", "url": "" }, { "id": "P07949", "database": "PRO", "url": "" }, { "id": "6NEC", "database": "PDB", "url": "" }, { "id": "NP_066124.1", "database": "RefSeq", "url": "" }, { "id": "P07949", "database": "Pharos - Targets", "url": "" }, { "id": "RET_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "7DU8", "database": "PDB", "url": "" }, { "id": "2X2M", "database": "PDB", "url": "" }, { "id": "RET_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "ENSG00000165731-RET", "database": "HPA", "url": "" }, { "id": "6FEK", "database": "PDB", "url": "" }, { "id": "P07949", "database": "UniProt", "url": "" }, { "id": "6I82", "database": "PDB", "url": "" }, { "id": "ENSP00000347942", "database": "Ensembl", "url": "" }, { "id": "6Q2O", "database": "PDB", "url": "" }, { "id": "2IVT", "database": "PDB", "url": "" }, { "id": "2IVV", "database": "PDB", "url": "" }, { "id": "ENSG00000165731", "database": "OpenTargets", "url": "" }, { "id": "5FM2", "database": "PDB", "url": "" }, { "id": "7JU5", "database": "PDB", "url": "" }, { "id": "5AMN", "database": "PDB", "url": "" }, { "id": "7DU9", "database": "PDB", "url": "" }, { "id": "2X2K", "database": "PDB", "url": "" }, { "id": "6I83", "database": "PDB", "url": "" }, { "id": "RET_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "5FM3", "database": "PDB", "url": "" }, { "id": "2IVU", "database": "PDB", "url": "" }, { "id": "2X2U", "database": "PDB", "url": "" }, { "id": "7NZN", "database": "PDB", "url": "" }, { "id": "7DUA", "database": "PDB", "url": "" }, { "id": "6Q2J", "database": "PDB", "url": "" }, { "id": "ENSG00000165731", "database": "Ensembl", "url": "" }, { "id": "RET_HUMAN", "database": "ZINC - FDA approved", "url": "" }, { "id": "6NE7", "database": "PDB", "url": "" }, { "id": "6GL7", "database": "PDB", "url": "" }, { "id": "4CKJ", "database": "PDB", "url": "" }, { "id": "6Q2R", "database": "PDB", "url": "" }, { "id": "ENST00000355710", "database": "Ensembl", "url": "" }, { "id": "P07949", "database": "ZINC target", "url": "" }, { "id": "RET_HUMAN", "database": "ZINC - Investigational", "url": "" } ] }, { "participant_id": "R-HSA-9770505", "participant_name": "RET gene [nucleoplasm]", "crossref": [ { "id": "ENSG00000165731", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-HSA-9830379", "participant_name": "RET gene [nucleoplasm]", "crossref": [ { "id": "ENSG00000165731", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-HSA-9830748", "participant_name": "WNT11 gene [nucleoplasm]", "crossref": [ { "id": "ENSG00000085741", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JW59", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] } ] }, { "uniprot_ac": "A0A0G2K6M9", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] } ] }, { "uniprot_ac": "A0A0R4J8U1", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] } ] }, { "uniprot_ac": "A0A8I5ZP97", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] } ] }, { "uniprot_ac": "A0A8I5ZVE3", "gene_name": "Ephb3", "activity": [ { 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ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] } ] }, { "uniprot_ac": "A0A8I6AWX7", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] } ] }, { "uniprot_ac": "A0A8I6GCV6", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] } ] }, { "uniprot_ac": "B1WC09", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] } ] }, { "uniprot_ac": "B2RYC7", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] } ] }, { "uniprot_ac": "B5DFD6", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] } ] }, { "uniprot_ac": "D3ZBN3", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] } ] }, { "uniprot_ac": "D3ZCD0", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] } ] }, { "uniprot_ac": "D3ZD03", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] } ] }, { "uniprot_ac": "D3ZDH4", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] } ] }, { "uniprot_ac": "D3ZDS3", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] } ] }, { "uniprot_ac": "D3ZJI4", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] } ] }, { "uniprot_ac": "D3ZZK3", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] } ] }, { "uniprot_ac": "D4A584", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] } ] }, { "uniprot_ac": "D4A7W7", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] } ] }, { "uniprot_ac": "D4ADZ5", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "E9PSY0", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] } ] }, { "uniprot_ac": "E9PT20", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] } ] }, { "uniprot_ac": "F1LM93", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] } ] }, { "uniprot_ac": "F1LRZ0", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] } ] }, { "uniprot_ac": "F1LSG7", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] } ] }, { "uniprot_ac": "F1LSN4", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] } ] }, { "uniprot_ac": "F1LVI0", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] } ] }, { "uniprot_ac": "F1LYY7", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] } ] }, { "uniprot_ac": "F1M0N1", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] } ] }, { "uniprot_ac": "F1MAJ0", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] } ] }, { "uniprot_ac": "G3V6K6", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "G3V9H8", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] } ] }, { "uniprot_ac": "M0R7E7", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] } ] }, { "uniprot_ac": "M0RDA4", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] } ] }, { "uniprot_ac": "O00329", "gene_name": "PIK3CD", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] } ] }, { "uniprot_ac": "O08680", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] } ] }, { "uniprot_ac": "O08775", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] } ] }, { "uniprot_ac": "O09110", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] } ] }, { "uniprot_ac": "O09127", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] } ] }, { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] } ] }, { "uniprot_ac": "O15146", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] } ] }, { "uniprot_ac": "O35346", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] } ] }, { "uniprot_ac": "O35491", "gene_name": "Clk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] } ] }, { "uniprot_ac": "O35492", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] } ] }, { "uniprot_ac": "O35493", "gene_name": "Clk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] } ] }, { "uniprot_ac": "O54804", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] } ] }, { "uniprot_ac": "O54967", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] } ] }, { "uniprot_ac": "O60674", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "O62602", "gene_name": "lic", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] } ] }, { "uniprot_ac": "O70146", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] } ] }, { "uniprot_ac": "O88697", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] } ] }, { "uniprot_ac": "P00519", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] } ] }, { "uniprot_ac": "P00520", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P00533", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] } ] }, { "uniprot_ac": "P01111", "gene_name": "NRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01111" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01111" } ] } ] }, { "uniprot_ac": "P01112", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01112" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01112" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P04626", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] } ] }, { "uniprot_ac": "P04629", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] } ] }, { "uniprot_ac": "P05480", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] } ] }, { "uniprot_ac": "P05532", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] } ] }, { "uniprot_ac": "P05622", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] } ] }, { "uniprot_ac": "P06239", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] } ] }, { "uniprot_ac": "P06240", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] } ] }, { "uniprot_ac": "P06241", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] } ] }, { "uniprot_ac": "P06494", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] } ] }, { "uniprot_ac": "P06784", "gene_name": "STE7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] } ] }, { "uniprot_ac": "P07332", "gene_name": "FES", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] } ] }, { "uniprot_ac": "P07333", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] } ] }, { "uniprot_ac": "P07947", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] } ] }, { "uniprot_ac": "P07948", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] } ] }, { "uniprot_ac": "P07949", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] } ] }, { "uniprot_ac": "P08018", "gene_name": "PBS2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] } ] }, { "uniprot_ac": "P08069", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] } ] }, { "uniprot_ac": "P08103", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] } ] }, { "uniprot_ac": "P08581", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] } ] }, { "uniprot_ac": "P08630", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] } ] }, { "uniprot_ac": "P08631", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] } ] }, { "uniprot_ac": "P08922", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] } ] }, { "uniprot_ac": "P08923", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] } ] }, { "uniprot_ac": "P09208", "gene_name": "InR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P09581", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09581" } ] } ] }, { "uniprot_ac": "P09619", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] } ] }, { "uniprot_ac": "P09759", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] } ] }, { "uniprot_ac": "P09760", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] } ] }, { "uniprot_ac": "P0C1S8", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] } ] }, { "uniprot_ac": "P10721", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] } ] }, { "uniprot_ac": "P11362", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12931", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] } ] }, { "uniprot_ac": "P13368", "gene_name": "sev", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] } ] }, { "uniprot_ac": "P14234", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] } ] }, { "uniprot_ac": "P14616", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14680", "gene_name": "YAK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] } ] }, { "uniprot_ac": "P15127", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] } ] }, { "uniprot_ac": "P15208", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] } ] }, { "uniprot_ac": "P15209", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] } ] }, { "uniprot_ac": "P16056", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] } ] }, { "uniprot_ac": "P16092", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] } ] }, { "uniprot_ac": "P16234", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] } ] }, { "uniprot_ac": "P16277", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] } ] }, { "uniprot_ac": "P16591", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] } ] }, { "uniprot_ac": "P16879", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] } ] }, { "uniprot_ac": "P17252", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P17252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17252" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P17252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17252" } ] } ] }, { "uniprot_ac": "P17612", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P17612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17612" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P17612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17612" } ] } ] }, { "uniprot_ac": "P17948", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P18160", "gene_name": "splA", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] } ] }, { "uniprot_ac": "P18161", "gene_name": "splB", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] } ] }, { "uniprot_ac": "P18433", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18433" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18433" } ] } ] }, { "uniprot_ac": "P18475", "gene_name": "tor", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] } ] }, { "uniprot_ac": "P19174", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] } ] }, { "uniprot_ac": "P20786", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] } ] }, { "uniprot_ac": "P21709", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] } ] }, { "uniprot_ac": "P21802", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] } ] }, { "uniprot_ac": "P21803", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] } ] }, { "uniprot_ac": "P21860", "gene_name": "ERBB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] } ] }, { "uniprot_ac": "P21965", "gene_name": "MCK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] } ] }, { "uniprot_ac": "P22216", "gene_name": "RAD53", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] } ] }, { "uniprot_ac": "P22455", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] } ] }, { "uniprot_ac": "P22518", "gene_name": "Clk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] } ] }, { "uniprot_ac": "P22607", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] } ] }, { "uniprot_ac": "P22612", "gene_name": "PRKACG", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22612" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P22612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22612" } ] } ] }, { "uniprot_ac": "P22694", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22694" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P22694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22694" } ] } ] }, { "uniprot_ac": "P23458", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] } ] }, { "uniprot_ac": "P24062", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] } ] }, { "uniprot_ac": "P24604", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] } ] }, { "uniprot_ac": "P25911", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] } ] }, { "uniprot_ac": "P26618", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P29317", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] } ] }, { "uniprot_ac": "P29319", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] } ] }, { "uniprot_ac": "P29320", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] } ] }, { "uniprot_ac": "P29321", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] } ] }, { "uniprot_ac": "P29322", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] } ] }, { "uniprot_ac": "P29323", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] } ] }, { "uniprot_ac": "P29376", "gene_name": "LTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] } ] }, { "uniprot_ac": "P29597", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] } ] }, { "uniprot_ac": "P30530", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] } ] }, { "uniprot_ac": "P31938", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] } ] }, { "uniprot_ac": "P32350", "gene_name": "KNS1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] } ] }, { "uniprot_ac": "P32490", "gene_name": "MKK1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] } ] }, { "uniprot_ac": "P32491", "gene_name": "MKK2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] } ] }, { "uniprot_ac": "P32577", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] } ] }, { "uniprot_ac": "P34152", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] } ] }, { "uniprot_ac": "P34925", "gene_name": "RYK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] } ] }, { "uniprot_ac": "P35546", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] } ] }, { "uniprot_ac": "P35590", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] } ] }, { "uniprot_ac": "P35739", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] } ] }, { "uniprot_ac": "P35761", "gene_name": "Ttk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] } ] }, { "uniprot_ac": "P35790", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] } ] }, { "uniprot_ac": "P35916", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] } ] }, { "uniprot_ac": "P35917", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] } ] }, { "uniprot_ac": "P35918", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] } ] }, { "uniprot_ac": "P35968", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] } ] }, { "uniprot_ac": "P35969", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] } ] }, { "uniprot_ac": "P35991", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] } ] }, { "uniprot_ac": "P36506", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] } ] }, { "uniprot_ac": "P36888", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] } ] }, { "uniprot_ac": "P39688", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] } ] }, { "uniprot_ac": "P41240", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] } ] }, { "uniprot_ac": "P41241", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] } ] }, { "uniprot_ac": "P41242", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] } ] }, { "uniprot_ac": "P41243", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] } ] }, { "uniprot_ac": "P42336", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] } ] }, { "uniprot_ac": "P42338", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] } ] }, { "uniprot_ac": "P42679", "gene_name": "MATK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] } ] }, { "uniprot_ac": "P42680", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] } ] }, { "uniprot_ac": "P42681", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] } ] }, { "uniprot_ac": "P42682", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] } ] }, { "uniprot_ac": "P42684", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] } ] }, { "uniprot_ac": "P42685", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] } ] }, { "uniprot_ac": "P43403", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] } ] }, { "uniprot_ac": "P43404", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] } ] }, { "uniprot_ac": "P43405", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] } ] }, { "uniprot_ac": "P47809", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] } ] }, { "uniprot_ac": "P47810", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] } ] }, { "uniprot_ac": "P48025", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P50545", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] } ] }, { "uniprot_ac": "P51451", "gene_name": "BLK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] } ] }, { "uniprot_ac": "P51813", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] } ] }, { "uniprot_ac": "P52332", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] } ] }, { "uniprot_ac": "P52333", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] } ] }, { "uniprot_ac": "P53767", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] } ] }, { "uniprot_ac": "P54199", "gene_name": "MPS1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] } ] }, { "uniprot_ac": "P54350", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] } ] }, { "uniprot_ac": "P54753", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] } ] }, { "uniprot_ac": "P54754", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] } ] }, { "uniprot_ac": "P54756", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] } ] }, { "uniprot_ac": "P54757", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] } ] }, { "uniprot_ac": "P54758", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] } ] }, { "uniprot_ac": "P54759", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] } ] }, { "uniprot_ac": "P54760", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] } ] }, { "uniprot_ac": "P54761", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] } ] }, { "uniprot_ac": "P54762", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] } ] }, { "uniprot_ac": "P54763", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] } ] }, { "uniprot_ac": "P54764", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] } ] }, { "uniprot_ac": "P55144", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] } ] }, { "uniprot_ac": "P55146", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] } ] }, { "uniprot_ac": "P57097", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] } ] }, { "uniprot_ac": "P57760", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] } ] }, { "uniprot_ac": "P58801", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] } ] }, { "uniprot_ac": "P70236", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] } ] }, { "uniprot_ac": "P70424", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] } ] }, { "uniprot_ac": "P70451", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] } ] }, { "uniprot_ac": "P70600", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P97504", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] } ] }, { "uniprot_ac": "P97523", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] } ] }, { "uniprot_ac": "P97793", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] } ] }, { "uniprot_ac": "Q00342", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] } ] }, { "uniprot_ac": "Q00495", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] } ] }, { "uniprot_ac": "Q00993", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] } ] }, { "uniprot_ac": "Q01134", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] } ] }, { "uniprot_ac": "Q01279", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] } ] }, { "uniprot_ac": "Q01621", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] } ] }, { "uniprot_ac": "Q01887", "gene_name": "Ryk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] } ] }, { "uniprot_ac": "Q01974", "gene_name": "ROR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] } ] }, { "uniprot_ac": "Q01986", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] } ] }, { "uniprot_ac": "Q02763", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] } ] }, { "uniprot_ac": "Q02858", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] } ] }, { "uniprot_ac": "Q03137", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] } ] }, { "uniprot_ac": "Q03142", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] } ] }, { "uniprot_ac": "Q03145", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] } ] }, { "uniprot_ac": "Q03146", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] } ] }, { "uniprot_ac": "Q03351", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] } ] }, { "uniprot_ac": "Q03526", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q04589", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] } ] }, { "uniprot_ac": "Q04736", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] } ] }, { "uniprot_ac": "Q04912", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] } ] }, { "uniprot_ac": "Q05030", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] } ] }, { "uniprot_ac": "Q05397", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06124", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] } ] }, { "uniprot_ac": "Q06187", "gene_name": "BTK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] } ] }, { "uniprot_ac": "Q06418", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] } ] }, { "uniprot_ac": "Q06806", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] } ] }, { "uniprot_ac": "Q07014", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] } ] }, { "uniprot_ac": "Q07407", "gene_name": "htl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] } ] }, { "uniprot_ac": "Q07912", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] } ] }, { "uniprot_ac": "Q08345", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] } ] }, { "uniprot_ac": "Q08881", "gene_name": "ITK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] } ] }, { "uniprot_ac": "Q09147", "gene_name": "btl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] } ] }, { "uniprot_ac": "Q12866", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] } ] }, { "uniprot_ac": "Q13163", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] } ] }, { "uniprot_ac": "Q13164", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13164" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q13164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13164" } ] } ] }, { "uniprot_ac": "Q13470", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] } ] }, { "uniprot_ac": "Q13554", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13554" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q13554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13554" } ] } ] }, { "uniprot_ac": "Q13555", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13555" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q13555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13555" } ] } ] }, { "uniprot_ac": "Q13557", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13557" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q13557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13557" } ] } ] }, { "uniprot_ac": "Q13627", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] } ] }, { "uniprot_ac": "Q13882", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] } ] }, { "uniprot_ac": "Q14289", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] } ] }, { "uniprot_ac": "Q14680", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] } ] }, { "uniprot_ac": "Q15303", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] } ] }, { "uniprot_ac": "Q15375", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] } ] }, { "uniprot_ac": "Q15569", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] } ] }, { "uniprot_ac": "Q16288", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] } ] }, { "uniprot_ac": "Q16620", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] } ] }, { "uniprot_ac": "Q16832", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24145", "gene_name": "Shark", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q24488", "gene_name": "Ror", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] } ] }, { "uniprot_ac": "Q24592", "gene_name": "hop", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] } ] }, { "uniprot_ac": "Q27324", "gene_name": "drl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] } ] }, { "uniprot_ac": "Q3UFB7", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] } ] }, { "uniprot_ac": "Q498D6", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] } ] }, { "uniprot_ac": "Q4JIM5", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] } ] }, { "uniprot_ac": "Q4KM97", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] } ] }, { "uniprot_ac": "Q4KSH6", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { "uniprot_ac": "Q4V8A3", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] } ] }, { "uniprot_ac": "Q501W1", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q501W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q501W1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q501W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q501W1" } ] } ] }, { "uniprot_ac": "Q504Y2", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] } ] }, { "uniprot_ac": "Q54BC9", "gene_name": "dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] } ] }, { "uniprot_ac": "Q54G28", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] } ] }, { "uniprot_ac": "Q54I36", "gene_name": "pyk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] } ] }, { "uniprot_ac": "Q54N73", "gene_name": "7tmk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] } ] }, { "uniprot_ac": "Q54QV3", "gene_name": "yakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] } ] }, { "uniprot_ac": "Q54R58", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] } ] }, { "uniprot_ac": "Q552C6", "gene_name": "zak2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] } ] }, { "uniprot_ac": "Q55CL6", "gene_name": "mekA", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] } ] }, { "uniprot_ac": "Q5FVG7", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] } ] }, { "uniprot_ac": "Q5JZY3", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] } ] }, { "uniprot_ac": "Q5RJI4", "gene_name": "Pkdcc", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] } ] }, { "uniprot_ac": "Q5U2X5", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] } ] }, { "uniprot_ac": "Q5U4C9", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] } ] }, { "uniprot_ac": "Q60629", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60629" } ] } ] }, { "uniprot_ac": "Q60750", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] } ] }, { "uniprot_ac": "Q60751", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] } ] }, { "uniprot_ac": "Q60805", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60805" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60805" } ] } ] }, { "uniprot_ac": "Q61006", "gene_name": "Musk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61006" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61006" } ] } ] }, { "uniprot_ac": "Q61214", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] } ] }, { "uniprot_ac": "Q61526", "gene_name": "Erbb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61526" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61526" } ] } ] }, { "uniprot_ac": "Q61527", "gene_name": "Erbb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61527" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61527" } ] } ] }, { "uniprot_ac": "Q61772", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61772" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61772" } ] } ] }, { "uniprot_ac": "Q61846", "gene_name": "Melk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61846" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q61846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61846" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61846" } ] } ] }, { "uniprot_ac": "Q61851", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61851" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61851" } ] } ] }, { "uniprot_ac": "Q62120", "gene_name": "Jak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62120" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62120" } ] } ] }, { "uniprot_ac": "Q62137", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62137" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62137" } ] } ] }, { "uniprot_ac": "Q62190", "gene_name": "Mst1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62190", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62190" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62190", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62190" } ] } ] }, { "uniprot_ac": "Q62270", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62270" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62270" } ] } ] }, { "uniprot_ac": "Q62371", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62371" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62371" } ] } ] }, { "uniprot_ac": "Q62413", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] } ] }, { "uniprot_ac": "Q62662", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] } ] }, { "uniprot_ac": "Q62689", "gene_name": "Jak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62689" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62689" } ] } ] }, { "uniprot_ac": "Q62799", "gene_name": "Erbb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] } ] }, { "uniprot_ac": "Q62838", "gene_name": "Musk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] } ] }, { "uniprot_ac": "Q62844", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] } ] }, { "uniprot_ac": "Q62862", "gene_name": "Map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] } ] }, { "uniprot_ac": "Q62956", "gene_name": "Erbb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] } ] }, { "uniprot_ac": "Q63116", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] } ] }, { "uniprot_ac": "Q63117", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] } ] }, { "uniprot_ac": "Q63132", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] } ] }, { "uniprot_ac": "Q63184", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] } ] }, { "uniprot_ac": "Q63272", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] } ] }, { "uniprot_ac": "Q63470", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] } ] }, { "uniprot_ac": "Q63474", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] } ] }, { "uniprot_ac": "Q63572", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] } ] }, { "uniprot_ac": "Q63604", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] } ] }, { "uniprot_ac": "Q63802", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] } ] }, { "uniprot_ac": "Q63932", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] } ] }, { "uniprot_ac": "Q64434", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64434" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64434" } ] } ] }, { "uniprot_ac": "Q64716", "gene_name": "Insrr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] } ] }, { "uniprot_ac": "Q64725", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] } ] }, { "uniprot_ac": "Q66JT0", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q66JT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q66JT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT0" } ] } ] }, { "uniprot_ac": "Q6J9G0", "gene_name": "STYK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6J9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6J9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G0" } ] } ] }, { "uniprot_ac": "Q6J9G1", "gene_name": "Styk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6J9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6J9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G1" } ] } ] }, { "uniprot_ac": "Q6P6U0", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] } ] }, { "uniprot_ac": "Q6VNS1", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] } ] }, { "uniprot_ac": "Q6XUX1", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] } ] }, { "uniprot_ac": "Q6XUX2", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX2" } ] } ] }, { "uniprot_ac": "Q6XUX3", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX3" } ] } ] }, { "uniprot_ac": "Q75JK0", "gene_name": "zakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] } ] }, { "uniprot_ac": "Q76NV1", "gene_name": "dyrk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] } ] }, { "uniprot_ac": "Q78DX7", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q78DX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78DX7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q78DX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78DX7" } ] } ] }, { "uniprot_ac": "Q7KJ08", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KJ08" } ] } ] }, { "uniprot_ac": "Q7KT06", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KT06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KT06" } ] } ] }, { "uniprot_ac": "Q8BI55", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] } ] }, { "uniprot_ac": "Q8BYG9", "gene_name": "Epha10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] } ] }, { "uniprot_ac": "Q8CBF3", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] } ] }, { "uniprot_ac": "Q8CE90", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q8VCT9", "gene_name": "Tesk2", "activity": 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"Q99ML2", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] } ] }, { "uniprot_ac": "Q9H3Y6", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] } ] }, { "uniprot_ac": "Q9HAZ1", "gene_name": "CLK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] 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] } ] }, { "uniprot_ac": "Q9VJ04", "gene_name": "Dmel\\CG10702", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] } ] }, { "uniprot_ac": "Q9VPC0", "gene_name": "Pitslre", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] } ] }, { "uniprot_ac": "Q9VZA8", "gene_name": "Tie", "activity": [ { "ec_number": "2.7.10.1", 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