{ "uniprot_canonical_ac": "P07947-1", "uniprot_ac": "P07947", "uniprot_id": "YES_HUMAN", "mass": { "chemical_mass": 60801.0, "monoisotopic_mass": 60801.0 }, "refseq": { "ac": "NP_005424", "name": "tyrosine-protein kinase Yes", "summary": "This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" }, "gene_names": [ { "name": "YES1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07947", "id": "P07947" }, { "name": "YES1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424", "id": "NP_005424" }, { "name": "YES", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07947", "id": "P07947" }, { "name": "c-yes; HsT441; P61-YES; Yes", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424", "id": "NP_005424" } ], "protein_names": [ { "name": "Tyrosine-protein kinase Yes", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07947" }, { "name": "2.7.10.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07947" }, { "name": "Proto-oncogene c-Yes", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07947" }, { "name": "Yamaguchi sarcoma oncogene; cellular yes-1 protein; proto-oncogene tyrosine-protein kinase YES; proto-oncogene c-Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; YES1 proto-oncogene, Src family tyrosine kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424", "id": "NP_005424" }, { "name": "p61-Yes", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07947" }, { "name": "tyrosine-protein kinase Yes", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424", "id": "NP_005424" } ], "function": [ { "annotation": "Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis. Erratum:[Respir Res. 2023 Jul 10;24(1):181. PMID: 37424028] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" }, { "database": "PubMed", "id": "37009887", "url": "https://glygen.org/publication/PubMed/37009887" } ] }, { "annotation": "Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" }, { "database": "PubMed", "id": "35015027", "url": "https://glygen.org/publication/PubMed/35015027" } ] }, { "annotation": "Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622).", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947#function" }, { "database": "PubMed", "id": "11901164", "url": "https://glygen.org/publication/PubMed/11901164" }, { "database": "PubMed", "id": "21566460", "url": "https://glygen.org/publication/PubMed/21566460" }, { "database": "PubMed", "id": "21713032", "url": "https://glygen.org/publication/PubMed/21713032" }, { "database": "PubMed", "id": "18479465", "url": "https://glygen.org/publication/PubMed/18479465" }, { "database": "PubMed", "id": "19276087", "url": "https://glygen.org/publication/PubMed/19276087" }, { "database": "PubMed", "id": "26979622", "url": "https://glygen.org/publication/PubMed/26979622" } ] }, { "annotation": "This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" } ] }, { "annotation": "YES1 Is a Druggable Oncogenic Target in SCLC.", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" }, { "database": "PubMed", "id": "35988891", "url": "https://glygen.org/publication/PubMed/35988891" } ] }, { "annotation": "YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" }, { "database": "PubMed", "id": "37371529", "url": "https://glygen.org/publication/PubMed/37371529" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 426, "end_pos": 426, "sequence_org": "Y", "sequence_mut": "F", "comment": "About 50% loss of CSK-mediated inhibition.", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "PubMed", "id": "9794236", "url": "https://glygen.org/publication/PubMed/9794236" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "86.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "94.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "86.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "81.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "85.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "91.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "81.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "87.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "88.84", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "92.94", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "82.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "88.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "P07947", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07947" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "common_name": "Human" } ], "gene": [ { "name": "YES1", "url": "https://www.uniprot.org/uniprot/P07947", "locus": { "chromosome": "18", "start_pos": 721588, "end_pos": 812546, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000176105", "url": "https://www.ensembl.org/id/ENSG00000176105" } ] } } ], "crossref": [ { "id": "ENSG00000176105", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176105", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.7.10.2", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.10.2&UniProtAcc=P07947", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd05069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09933", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09933", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12007", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12007", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL2073", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2073", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "YES1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=YES1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "7525", "url": "https://www.ncbi.nlm.nih.gov/gene/7525", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "12841", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12841", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "J3QRU1", "url": "https://www.ebi.ac.uk/intact/interactors/id:J3QRU1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "P07947", "url": "https://www.ebi.ac.uk/intact/interactors/id:P07947*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:7525", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7525", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "164880", "url": "http://www.omim.org/entry/164880", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P07947", "url": "https://www.nextprot.org/entry/NX_P07947", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P07947", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P07947", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "1614410at2759", "url": "http://www.orthodb.org/?query=1614410at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24418", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24418", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24418:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24418:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2HDA", "url": "https://www.rcsb.org/structure/2HDA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00017", "url": "http://pfam.xfam.org/family/PF00017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "http://pfam.xfam.org/family/PF07714", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P07947", "url": "https://pharos.nih.gov/targets/P07947", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P07947", "url": "http://purl.obolibrary.org/obo/PR_P07947", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928663", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "J3QRU1", "url": "https://www.uniprot.org/uniprot/J3QRU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QRU1-1", "url": "https://www.uniprot.org/uniprot/J3QRU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07947-1", "url": "https://www.uniprot.org/uniprot/P07947-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL", "length": 543, "header": "sp|P07947-1|YES_HUMAN Isoform 1 of Tyrosine-protein kinase Yes OS=Homo sapiens OX=9606 GN=YES1 PE=1 SV=3 CANONICAL=P07947-1" }, "isoforms": [ { "isoform_ac": "J3QRU1-1", "url": "", "sequence": { "sequence": "MLDLIMGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL", "length": 548, "header": "tr|J3QRU1-1|J3QRU1_HUMAN Computationally mapped isoform of Tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=YES1 PE=1 SV=1 CANONICAL=P07947-1" }, "locus": { "chromosome": "18", "start_pos": 775195, "end_pos": 724427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000577961.5", "url": "https://www.ensembl.org/id/ENST00000577961.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464380.1", "url": "https://www.ensembl.org/id/ENSP00000464380.1" } ] } }, { "isoform_ac": "P07947-1", "url": "", "sequence": { "sequence": "MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL", "length": 543, "header": "sp|P07947-1|YES_HUMAN Isoform 1 of Tyrosine-protein kinase Yes OS=Homo sapiens OX=9606 GN=YES1 PE=1 SV=3 CANONICAL=P07947-1" }, "locus": { "chromosome": "18", "start_pos": 756827, "end_pos": 724427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000584307.5", "url": "https://www.ensembl.org/id/ENST00000584307.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000462468.1", "url": "https://www.ensembl.org/id/ENSP00000462468.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P07947", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P07947" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 111, "end_pos": 111, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser111" }, { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser11" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Tyr194" }, { "start_pos": 195, "end_pos": 195, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser195" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Thr21" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" } ], "site_lbl": "Tyr222" }, { "start_pos": 223, "end_pos": 223, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" } ], "site_lbl": "Tyr223" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser26" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Thr27" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser28" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser30" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "P07947-1", "kinase_gene_name": "YES1", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "9058199", "url": "https://glygen.org/publication/PubMed/9058199" } ], "site_lbl": "Tyr32" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" }, { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" } ], "site_lbl": "Tyr32" }, { "start_pos": 336, "end_pos": 336, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "site_lbl": "Tyr336" }, { "start_pos": 345, "end_pos": 345, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "site_lbl": "Tyr345" }, { "start_pos": 40, "end_pos": 40, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser40" }, { "start_pos": 426, "end_pos": 426, "kinase_uniprot_canonical_ac": "P07947-1", "kinase_gene_name": "YES1", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "9794236", "url": "https://glygen.org/publication/PubMed/9794236" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "9058199", "url": "https://glygen.org/publication/PubMed/9058199" }, { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "site_lbl": "Tyr426" }, { "start_pos": 426, "end_pos": 426, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by autocatalysis", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "16094384", "url": "https://glygen.org/publication/PubMed/16094384" }, { "database": "PubMed", "id": "17192257", "url": "https://glygen.org/publication/PubMed/17192257" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" }, { "database": "PubMed", "id": "9794236", "url": "https://glygen.org/publication/PubMed/9794236" } ], "site_lbl": "Tyr426" }, { "start_pos": 446, "end_pos": 446, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" }, { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" } ], "site_lbl": "Tyr446" }, { "start_pos": 44, "end_pos": 44, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" } ], "site_lbl": "Ser44" }, { "start_pos": 45, "end_pos": 45, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser45" }, { "start_pos": 537, "end_pos": 537, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by CSK", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "phospho.ELM", "id": "P07947", "url": "http://phospho.elm.eu.org/byAccession/P07947.html" }, { "database": "PubMed", "id": "7690925", "url": "https://glygen.org/publication/PubMed/7690925" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" } ], "site_lbl": "Tyr537" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.", "journal": "Cell", "date": "1999", "authors": "Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "10219243", "url": "https://glygen.org/publication/PubMed/10219243" } ] }, { "title": "Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.", "journal": "FEBS letters", "date": "1999", "authors": "Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, Lord JM, Wakelam MJ, Bird IN, Salmon M, Buckley CD", "evidence": [ { "database": "Reactome", "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990" } ], "reference": [ { "type": "PubMed", "id": "10350061", "url": "https://glygen.org/publication/PubMed/10350061" } ] }, { "title": "STAT protein recruitment and activation in c-Kit deletion mutants.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Brizzi MF, Dentelli P, Rosso A, Yarden Y, Pegoraro L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10358045", "url": "https://glygen.org/publication/PubMed/10358045" } ] }, { "title": "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.", "journal": "Leukemia", "date": "1999", "authors": "Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "10374881", "url": "https://glygen.org/publication/PubMed/10374881" } ] }, { "title": "Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.", "journal": "The Biochemical journal", "date": "1999", "authors": "Thommes K, Lennartsson J, Carlberg M, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10377264", "url": "https://glygen.org/publication/PubMed/10377264" } ] }, { "title": "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor.", "journal": "Blood", "date": "1999", "authors": "Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10397721", "url": "https://glygen.org/publication/PubMed/10397721" } ] }, { "title": "CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Newton JP, Hunter AP, Simmons DL, Buckley CD, Harvey DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990" } ], "reference": [ { "type": "PubMed", "id": "10425179", "url": "https://glygen.org/publication/PubMed/10425179" } ] }, { "title": "Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction.", "journal": "Oncogene", "date": "1999", "authors": "Lennartsson J, Blume-Jensen P, Hermanson M, Ponten E, Carlberg M, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10523831", "url": "https://glygen.org/publication/PubMed/10523831" } ] }, { "title": "Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts.", "journal": "Oncogene", "date": "1999", "authors": "Caruana G, Cambareri AC, Ashman LK", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10523834", "url": "https://glygen.org/publication/PubMed/10523834" } ] }, { "title": "Phospholipase C-gamma as a signal-transducing element.", "journal": "Experimental cell research", "date": "1999", "authors": "Carpenter G, Ji Qs", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "10579907", "url": "https://glygen.org/publication/PubMed/10579907" } ] }, { "title": "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10679268", "url": "https://glygen.org/publication/PubMed/10679268" } ] }, { "title": "Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Schneider H, Rudd CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "10694513", "url": "https://glygen.org/publication/PubMed/10694513" } ] }, { "title": "Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.", "journal": "Nature", "date": "2000", "authors": "Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "10724160", "url": "https://glygen.org/publication/PubMed/10724160" } ] }, { "title": "Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Wahl S, Barth H, Ciossek T, Aktories K, Mueller BK", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928663" } ], "reference": [ { "type": "PubMed", "id": "10769020", "url": "https://glygen.org/publication/PubMed/10769020" } ] }, { "title": "Structural analysis of CTLA-4 function in vivo.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2000", "authors": "Masteller EL, Chuang E, Mullen AC, Reiner SL, Thompson CB", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "10799894", "url": "https://glygen.org/publication/PubMed/10799894" } ] }, { "title": "Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Binns KL, Taylor PP, Sicheri F, Pawson T, Holland SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "10848605", "url": "https://glygen.org/publication/PubMed/10848605" } ] }, { "title": "Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Cicmil M, Thomas JM, Sage T, Barry FA, Leduc M, Bon C, Gibbins JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990" } ], "reference": [ { "type": "PubMed", "id": "10858437", "url": "https://glygen.org/publication/PubMed/10858437" } ] }, { "title": "Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2000", "authors": "Suzuki T, Kono H, Hirose N, Okada M, Yamamoto T, Yamamoto K, Honda Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "10861086", "url": "https://glygen.org/publication/PubMed/10861086" } ] }, { "title": "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor.", "journal": "Nature cell biology", "date": "2000", "authors": "Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adelaide J, Margolis B, Birnbaum D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "10878805", "url": "https://glygen.org/publication/PubMed/10878805" } ] }, { "title": "Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10884405", "url": "https://glygen.org/publication/PubMed/10884405" } ] }, { "title": "Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Rohatgi R, Ho HY, Kirschner MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "10995436", "url": "https://glygen.org/publication/PubMed/10995436" } ] }, { "title": "Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Higgs HN, Pollard TD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "10995437", "url": "https://glygen.org/publication/PubMed/10995437" } ] }, { "title": "Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "van Horck FP, Ahmadian MR, Haeusler LC, Moolenaar WH, Kranenburg O", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "11058585", "url": "https://glygen.org/publication/PubMed/11058585" } ] }, { "title": "Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Xu W, Mimnaugh E, Rosser MF, Nicchitta C, Marcu M, Yarden Y, Neckers L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "11071886", "url": "https://glygen.org/publication/PubMed/11071886" } ] }, { "title": "Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Kern B, Shen J, Starbuck M, Karsenty G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "11106645", "url": "https://glygen.org/publication/PubMed/11106645" } ] }, { "title": "Temporal and spatial distribution of activated Pak1 in fibroblasts.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Sells MA, Pfaff A, Chernoff J", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "11134074", "url": "https://glygen.org/publication/PubMed/11134074" } ] }, { "title": "Rho GTPases in growth cone guidance.", "journal": "Current opinion in neurobiology", "date": "2001", "authors": "Dickson BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928663" } ], "reference": [ { "type": "PubMed", "id": "11179879", "url": "https://glygen.org/publication/PubMed/11179879" } ] }, { "title": "Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells.", "journal": "Blood", "date": "2001", "authors": "Ning ZQ, Li J, Arceci RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "11369651", "url": "https://glygen.org/publication/PubMed/11369651" } ] }, { "title": "Synthesis and function of 3-phosphorylated inositol lipids.", "journal": "Annual review of biochemistry", "date": "2001", "authors": "Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "11395417", "url": "https://glygen.org/publication/PubMed/11395417" } ] }, { "title": "Vav2 is required for cell spreading.", "journal": "The Journal of cell biology", "date": "2001", "authors": "Marignani PA, Carpenter CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "11448999", "url": "https://glygen.org/publication/PubMed/11448999" } ] }, { "title": "STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity.", "journal": "Oncogene", "date": "2001", "authors": "Ning ZQ, Li J, McGuinness M, Arceci RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "11494148", "url": "https://glygen.org/publication/PubMed/11494148" } ] }, { "title": "Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant.", "journal": "Blood", "date": "2001", "authors": "Chian R, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, Ashman L, Linnekin D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "11520784", "url": "https://glygen.org/publication/PubMed/11520784" } ] }, { "title": "The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation.", "journal": "Molecular cell", "date": "2001", "authors": "Thomas DM, Carty SA, Piscopo DM, Lee JS, Wang WF, Forrester WC, Hinds PW", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "11545733", "url": "https://glygen.org/publication/PubMed/11545733" } ] }, { "title": "EphB/syndecan-2 signaling in dendritic spine morphogenesis.", "journal": "Neuron", "date": "2001", "authors": "Ethell IM, Irie F, Kalo MS, Couchman JR, Pasquale EB, Yamaguchi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "11580899", "url": "https://glygen.org/publication/PubMed/11580899" } ] }, { "title": "ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen.", "journal": "The EMBO journal", "date": "2001", "authors": "Nicholson PR, Empereur S, Glover HR, Dilworth SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "11707405", "url": "https://glygen.org/publication/PubMed/11707405" } ] }, { "title": "Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities.", "journal": "Current biology : CB", "date": "2001", "authors": "Zalevsky J, Lempert L, Kranitz H, Mullins RD", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "11747816", "url": "https://glygen.org/publication/PubMed/11747816" } ] }, { "title": "Crystal structure of an Eph receptor-ephrin complex.", "journal": "Nature", "date": "2001", "authors": "Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "11780069", "url": "https://glygen.org/publication/PubMed/11780069" } ] }, { "title": "Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.", "journal": "Molecular cell", "date": "2002", "authors": "Parrini MC, Lei M, Harrison SC, Mayer BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "11804587", "url": "https://glygen.org/publication/PubMed/11804587" } ] }, { "title": "Role for the adaptor protein Grb10 in the activation of Akt.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Jahn T, Seipel P, Urschel S, Peschel C, Duyster J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "11809791", "url": "https://glygen.org/publication/PubMed/11809791" } ] }, { "title": "Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages.", "journal": "Molecular biology of the cell", "date": "2002", "authors": "Diakonova M, Bokoch G, Swanson JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "11854399", "url": "https://glygen.org/publication/PubMed/11854399" } ] }, { "title": "CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Lee SW, Bonnah RA, Higashi DL, Atkinson JP, Milgram SL, So M", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "11901164", "url": "https://glygen.org/publication/PubMed/11901164" } ] }, { "title": "Structural mechanisms of costimulation.", "journal": "Nature immunology", "date": "2002", "authors": "Schwartz JC, Zhang X, Nathenson SG, Almo SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "11976720", "url": "https://glygen.org/publication/PubMed/11976720" } ] }, { "title": "Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2002", "authors": "Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "11994459", "url": "https://glygen.org/publication/PubMed/11994459" } ] }, { "title": "The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system.", "journal": "Journal of leukocyte biology", "date": "2002", "authors": "Rao N, Dodge I, Band H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "11994499", "url": "https://glygen.org/publication/PubMed/11994499" } ] }, { "title": "Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.", "journal": "Cell", "date": "2002", "authors": "Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "12062105", "url": "https://glygen.org/publication/PubMed/12062105" } ] }, { "title": "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Prevost N, Woulfe D, Tanaka T, Brass LF", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "12084815", "url": "https://glygen.org/publication/PubMed/12084815" } ] }, { "title": "Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis.", "journal": "Infection and immunity", "date": "2002", "authors": "Morehead J, Coppens I, Andrews NW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "12117970", "url": "https://glygen.org/publication/PubMed/12117970" } ] }, { "title": "Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Craig AW, Greer PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "12192036", "url": "https://glygen.org/publication/PubMed/12192036" } ] }, { "title": "Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms.", "journal": "EMBO reports", "date": "2002", "authors": "Wee HJ, Huang G, Shigesada K, Ito Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "12231506", "url": "https://glygen.org/publication/PubMed/12231506" } ] }, { "title": "Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "12391164", "url": "https://glygen.org/publication/PubMed/12391164" } ] }, { "title": "Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Zhang J, Berenstein E, Siraganian RP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "12417718", "url": "https://glygen.org/publication/PubMed/12417718" } ] }, { "title": "The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.", "journal": "The Biochemical journal", "date": "2003", "authors": "Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "12444928", "url": "https://glygen.org/publication/PubMed/12444928" } ] }, { "title": "The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Tatton L, Morley GM, Chopra R, Khwaja A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "12475982", "url": "https://glygen.org/publication/PubMed/12475982" } ] }, { "title": "Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.", "journal": "Molecular cancer therapeutics", "date": "2002", "authors": "Frost MJ, Ferrao PT, Hughes TP, Ashman LK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "12481435", "url": "https://glygen.org/publication/PubMed/12481435" } ] }, { "title": "Eph signaling: a structural view.", "journal": "Trends in neurosciences", "date": "2003", "authors": "Himanen JP, Nikolov DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "12495863", "url": "https://glygen.org/publication/PubMed/12495863" } ] }, { "title": "Src family kinases are involved in the differential signaling from two splice forms of c-Kit.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Voytyuk O, Lennartsson J, Mogi A, Caruana G, Courtneidge S, Ashman LK, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "12511554", "url": "https://glygen.org/publication/PubMed/12511554" } ] }, { "title": "Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Cui CB, Cooper LF, Yang X, Karsenty G, Aukhil I", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "12529404", "url": "https://glygen.org/publication/PubMed/12529404" } ] }, { "title": "Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.", "journal": "Neuron", "date": "2003", "authors": "Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, Huganir RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "12546821", "url": "https://glygen.org/publication/PubMed/12546821" } ] }, { "title": "Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling.", "journal": "Experimental cell research", "date": "2003", "authors": "Vijapurkar U, Kim MS, Koland JG", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "12651161", "url": "https://glygen.org/publication/PubMed/12651161" } ] }, { "title": "The role of PI3K in immune cells.", "journal": "Nature immunology", "date": "2003", "authors": "Koyasu S", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "12660731", "url": "https://glygen.org/publication/PubMed/12660731" } ] }, { "title": "Direct interaction of focal adhesion kinase with p190RhoGEF.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Zhai J, Lin H, Nie Z, Wu J, Canete-Soler R, Schlaepfer WW, Schlaepfer DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "12702722", "url": "https://glygen.org/publication/PubMed/12702722" } ] }, { "title": "Interleukin-10 therapy--review of a new approach.", "journal": "Pharmacological reviews", "date": "2003", "authors": "Asadullah K, Sterry W, Volk HD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "12773629", "url": "https://glygen.org/publication/PubMed/12773629" } ] }, { "title": "Structure of a c-kit product complex reveals the basis for kinase transactivation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Mol CD, Lim KB, Sridhar V, Zou H, Chien EY, Sang BC, Nowakowski J, Kassel DB, Cronin CN, McRee DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "12824176", "url": "https://glygen.org/publication/PubMed/12824176" } ] }, { "title": "Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.", "journal": "Nature reviews. Immunology", "date": "2003", "authors": "Rudd CE, Schneider H", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "12876557", "url": "https://glygen.org/publication/PubMed/12876557" } ] }, { "title": "Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.", "journal": "Experimental cell research", "date": "2003", "authors": "Lennartsson J, Wernstedt C, Engstrom U, Hellman U, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "12878163", "url": "https://glygen.org/publication/PubMed/12878163" } ] }, { "title": "Cbl-mediated ubiquitinylation and negative regulation of Vav.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "12881521", "url": "https://glygen.org/publication/PubMed/12881521" } ] }, { "title": "The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "12882960", "url": "https://glygen.org/publication/PubMed/12882960" } ] }, { "title": "Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion.", "journal": "Nature cell biology", "date": "2003", "authors": "Marston DJ, Dickinson S, Nobes CD", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "12973357", "url": "https://glygen.org/publication/PubMed/12973357" } ] }, { "title": "Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.", "journal": "The Journal of experimental medicine", "date": "1992", "authors": "Wirthmueller U, Kurosaki T, Murakami MS, Ravetch JV", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "1314888", "url": "https://glygen.org/publication/PubMed/1314888" } ] }, { "title": "Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.", "journal": "The EMBO journal", "date": "1992", "authors": "Nakamura T, Lin LL, Kharbanda S, Knopf J, Kufe D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "1334462", "url": "https://glygen.org/publication/PubMed/1334462" } ] }, { "title": "p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Duronio V, Welham MJ, Abraham S, Dryden P, Schrader JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "1371879", "url": "https://glygen.org/publication/PubMed/1371879" } ] }, { "title": "Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Huang MM, Indik Z, Brass LF, Hoxie JA, Schreiber AD, Brugge JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "1372004", "url": "https://glygen.org/publication/PubMed/1372004" } ] }, { "title": "A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Lev S, Yarden Y, Givol D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "1375232", "url": "https://glygen.org/publication/PubMed/1375232" } ] }, { "title": "Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Alai M, Mui AL, Cutler RL, Bustelo XR, Barbacid M, Krystal G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "1381360", "url": "https://glygen.org/publication/PubMed/1381360" } ] }, { "title": "KIT mutations are common in testicular seminomas.", "journal": "The American journal of pathology", "date": "2004", "authors": "Kemmer K, Corless CL, Fletcher JA, McGreevey L, Haley A, Griffith D, Cummings OW, Wait C, Town A, Heinrich MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "14695343", "url": "https://glygen.org/publication/PubMed/14695343" } ] }, { "title": "Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription.", "journal": "The EMBO journal", "date": "2004", "authors": "Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "14765127", "url": "https://glygen.org/publication/PubMed/14765127" } ] }, { "title": "Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.", "journal": "The EMBO journal", "date": "2004", "authors": "Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "14988728", "url": "https://glygen.org/publication/PubMed/14988728" } ] }, { "title": "Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).", "journal": "Oncogene", "date": "2004", "authors": "Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Fletcher CD, Demetri GD, Fletcher JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "15007386", "url": "https://glygen.org/publication/PubMed/15007386" } ] }, { "title": "Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer.", "journal": "The American journal of pathology", "date": "2004", "authors": "Paronetto MP, Farini D, Sammarco I, Maturo G, Vespasiani G, Geremia R, Rossi P, Sette C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "15039213", "url": "https://glygen.org/publication/PubMed/15039213" } ] }, { "title": "An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.", "journal": "Immunity", "date": "2004", "authors": "Vijayakrishnan L, Slavik JM, Illes Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "15142525", "url": "https://glygen.org/publication/PubMed/15142525" } ] }, { "title": "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Argetsinger LS, Kouadio JL, Steen H, Stensballe A, Jensen ON, Carter-Su C", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "15143187", "url": "https://glygen.org/publication/PubMed/15143187" } ] }, { "title": "Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Sekiya F, Poulin B, Kim YJ, Rhee SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "15161916", "url": "https://glygen.org/publication/PubMed/15161916" } ] }, { "title": "Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Parker M, Roberts R, Enriquez M, Zhao X, Takahashi T, Pat Cerretti D, Daniel T, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "15351694", "url": "https://glygen.org/publication/PubMed/15351694" } ] }, { "title": "Control of axonal branching and synapse formation by focal adhesion kinase.", "journal": "Nature neuroscience", "date": "2004", "authors": "Rico B, Beggs HE, Schahin-Reed D, Kimes N, Schmidt A, Reichardt LF", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "15378065", "url": "https://glygen.org/publication/PubMed/15378065" } ] }, { "title": "Regulation of WASP/WAVE proteins: making a long story short.", "journal": "The Journal of cell biology", "date": "2004", "authors": "Bompard G, Caron E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "15452139", "url": "https://glygen.org/publication/PubMed/15452139" } ] }, { "title": "Signal transduction via the stem cell factor receptor/c-Kit.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2004", "authors": "Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "15526160", "url": "https://glygen.org/publication/PubMed/15526160" } ] }, { "title": "PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.", "journal": "The Biochemical journal", "date": "2005", "authors": "Zhao ZS, Manser E", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "15548136", "url": "https://glygen.org/publication/PubMed/15548136" } ] }, { "title": "Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.", "journal": "EMBO reports", "date": "2004", "authors": "Citri A, Gan J, Mosesson Y, Vereb G, Szollosi J, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "15568014", "url": "https://glygen.org/publication/PubMed/15568014" } ] }, { "title": "Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.", "journal": "Nature structural & molecular biology", "date": "2005", "authors": "Xu W, Yuan X, Xiang Z, Mimnaugh E, Marcu M, Neckers L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "15643424", "url": "https://glygen.org/publication/PubMed/15643424" } ] }, { "title": "The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines.", "journal": "Neuron", "date": "2005", "authors": "Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "15721239", "url": "https://glygen.org/publication/PubMed/15721239" } ] }, { "title": "Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.", "journal": "Blood", "date": "2005", "authors": "Growney JD, Clark JJ, Adelsperger J, Stone R, Fabbro D, Griffin JD, Gilliland DG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "15790786", "url": "https://glygen.org/publication/PubMed/15790786" } ] }, { "title": "Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse.", "journal": "Neuron", "date": "2005", "authors": "Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928663" } ], "reference": [ { "type": "PubMed", "id": "15848799", "url": "https://glygen.org/publication/PubMed/15848799" } ] }, { "title": "Vav family GEFs link activated Ephs to endocytosis and axon guidance.", "journal": "Neuron", "date": "2005", "authors": "Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "15848800", "url": "https://glygen.org/publication/PubMed/15848800" } ] }, { "title": "Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2005", "authors": "Padigel UM, Farrell JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "15879134", "url": "https://glygen.org/publication/PubMed/15879134" } ] }, { "title": "Mutations in NOTCH1 cause aortic valve disease.", "journal": "Nature", "date": "2005", "authors": "Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "16025100", "url": "https://glygen.org/publication/PubMed/16025100" } ] }, { "title": "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.", "journal": "Nature methods", "date": "2005", "authors": "Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "16094384", "url": "https://glygen.org/publication/PubMed/16094384" } ] }, { "title": "TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.", "journal": "Science (New York, N.Y.)", "date": "2005", "authors": "Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "16099986", "url": "https://glygen.org/publication/PubMed/16099986" } ] }, { "title": "Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Roskoski R Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "16129412", "url": "https://glygen.org/publication/PubMed/16129412" } ] }, { "title": "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Nakai Y, Nonomura N, Oka D, Shiba M, Arai Y, Nakayama M, Inoue H, Nishimura K, Aozasa K, Mizutani Y, Miki T, Okuyama A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "16188233", "url": "https://glygen.org/publication/PubMed/16188233" } ] }, { "title": "EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Moeller ML, Shi Y, Reichardt LF, Ethell IM", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "16298995", "url": "https://glygen.org/publication/PubMed/16298995" } ] }, { "title": "c-Yes response to growth factor activation.", "journal": "Growth Factors", "date": "2005", "authors": "Clump David A, Qazi Ihtishaam H, Sudol Marius, Flynn Daniel C", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "16338789", "url": "https://glygen.org/publication/PubMed/16338789" } ] }, { "title": "Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies.", "journal": "Cancer research", "date": "2006", "authors": "Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "16397263", "url": "https://glygen.org/publication/PubMed/16397263" } ] }, { "title": "Stem cell factor and its receptor c-Kit as targets for inflammatory diseases.", "journal": "European journal of pharmacology", "date": "2006", "authors": "Reber L, Da Silva CA, Frossard N", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "16483568", "url": "https://glygen.org/publication/PubMed/16483568" } ] }, { "title": "Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling.", "journal": "The EMBO journal", "date": "2006", "authors": "Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "16511561", "url": "https://glygen.org/publication/PubMed/16511561" } ] }, { "title": "Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.", "journal": "Immunity", "date": "2006", "authors": "Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "16546099", "url": "https://glygen.org/publication/PubMed/16546099" } ] }, { "title": "A molecular perspective of CTLA-4 function.", "journal": "Annual review of immunology", "date": "2006", "authors": "Teft WA, Kirchhof MG, Madrenas J", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "16551244", "url": "https://glygen.org/publication/PubMed/16551244" } ] }, { "title": "Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms.", "journal": "Cancer research", "date": "2006", "authors": "Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M, Godwin AK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "16707477", "url": "https://glygen.org/publication/PubMed/16707477" } ] }, { "title": "Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.", "journal": "Cytokine & growth factor reviews", "date": "2006", "authors": "Hafizi S, Dahlback B", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "16737840", "url": "https://glygen.org/publication/PubMed/16737840" } ] }, { "title": "SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.", "journal": "Cell", "date": "2006", "authors": "Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "16751105", "url": "https://glygen.org/publication/PubMed/16751105" } ] }, { "title": "Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.", "journal": "The Biochemical journal", "date": "2006", "authors": "Masson K, Heiss E, Band H, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "16780420", "url": "https://glygen.org/publication/PubMed/16780420" } ] }, { "title": "Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2006", "authors": "Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R", "evidence": [ { "database": "Reactome", "id": "R-HSA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356" } ], "reference": [ { "type": "PubMed", "id": "16818765", "url": "https://glygen.org/publication/PubMed/16818765" } ] }, { "title": "The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "16873377", "url": "https://glygen.org/publication/PubMed/16873377" } ] }, { "title": "Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.", "journal": "The Journal of biological chemistry", "date": "1990", "authors": "Walton GM, Chen WS, Rosenfeld MG, Gill GN", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "1688559", "url": "https://glygen.org/publication/PubMed/1688559" } ] }, { "title": "Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Rossi F, Ehlers I, Agosti V, Socci ND, Viale A, Sommer G, Yozgat Y, Manova K, Antonescu CR, Besmer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "16908864", "url": "https://glygen.org/publication/PubMed/16908864" } ] }, { "title": "Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.", "journal": "Journal of leukocyte biology", "date": "2006", "authors": "Huang ZY, Barreda DR, Worth RG, Indik ZK, Kim MK, Chien P, Schreiber AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "16921024", "url": "https://glygen.org/publication/PubMed/16921024" } ] }, { "title": "Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.", "journal": "Cellular signalling", "date": "2007", "authors": "Li Z, Mei Y, Liu X, Zhou M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "16978839", "url": "https://glygen.org/publication/PubMed/16978839" } ] }, { "title": "Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Xu W, Yuan X, Beebe K, Xiang Z, Neckers L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "17030621", "url": "https://glygen.org/publication/PubMed/17030621" } ] }, { "title": "Identification of autophosphorylation sites of HER2/neu.", "journal": "Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research", "date": "1990", "authors": "Hazan R, Margolis B, Dombalagian M, Ullrich A, Zilberstein A, Schlessinger J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "1706616", "url": "https://glygen.org/publication/PubMed/1706616" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Wissing J, Jansch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "17192257", "url": "https://glygen.org/publication/PubMed/17192257" } ] }, { "title": "Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2007", "authors": "Song H, Zhang J, Chiang YJ, Siraganian RP, Hodes RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "17202354", "url": "https://glygen.org/publication/PubMed/17202354" } ] }, { "title": "Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase.", "journal": "Experimental hematology", "date": "1991", "authors": "Miyazawa K, Hendrie PC, Mantel C, Wood K, Ashman LK, Broxmeyer HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "1721591", "url": "https://glygen.org/publication/PubMed/1721591" } ] }, { "title": "Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.", "journal": "The EMBO journal", "date": "2007", "authors": "Liu H, Chen X, Focia PJ, He X", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "17255936", "url": "https://glygen.org/publication/PubMed/17255936" } ] }, { "title": "Role of CrkII in Fcgamma receptor-mediated phagocytosis.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Lee WL, Cosio G, Ireton K, Grinstein S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "17308335", "url": "https://glygen.org/publication/PubMed/17308335" } ] }, { "title": "Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay.", "journal": "Protein science : a publication of the Protein Society", "date": "2007", "authors": "Pabbisetty KB, Yue X, Li C, Himanen JP, Zhou R, Nikolov DB, Hu L", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "17322526", "url": "https://glygen.org/publication/PubMed/17322526" } ] }, { "title": "Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19.", "journal": "Journal of cell science", "date": "2007", "authors": "Kawaguchi N, Horiuchi K, Becherer JD, Toyama Y, Besmer P, Blobel CP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "17344430", "url": "https://glygen.org/publication/PubMed/17344430" } ] }, { "title": "Patterns of somatic mutation in human cancer genomes.", "journal": "Nature", "date": "2007", "authors": "Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "17344846", "url": "https://glygen.org/publication/PubMed/17344846" } ] }, { "title": "Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation.", "journal": "FEBS Lett.", "date": "2007", "authors": "Mart\u00edn-Garc\u00eda Jos\u00e9 M, Luque Irene, Mateo Pedro L, Ruiz-Sanz Javier, C\u00e1mara-Artigas Ana", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "17418139", "url": "https://glygen.org/publication/PubMed/17418139" } ] }, { "title": "Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "17428795", "url": "https://glygen.org/publication/PubMed/17428795" } ] }, { "title": "The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "17440041", "url": "https://glygen.org/publication/PubMed/17440041" } ] }, { "title": "KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance.", "journal": "Oncogene", "date": "2007", "authors": "Zhu MJ, Ou WB, Fletcher CD, Cohen PS, Demetri GD, Fletcher JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "17452978", "url": "https://glygen.org/publication/PubMed/17452978" } ] }, { "title": "KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway.", "journal": "Oncogene", "date": "2007", "authors": "Bauer S, Duensing A, Demetri GD, Fletcher JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "17546049", "url": "https://glygen.org/publication/PubMed/17546049" } ] }, { "title": "Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway.", "journal": "The Journal of cell biology", "date": "2007", "authors": "Lin YL, Lei YT, Hong CJ, Hsueh YP", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "17548511", "url": "https://glygen.org/publication/PubMed/17548511" } ] }, { "title": "Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.", "journal": "Cell", "date": "2007", "authors": "Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "17662946", "url": "https://glygen.org/publication/PubMed/17662946" } ] }, { "title": "Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.", "journal": "Experimental cell research", "date": "2007", "authors": "Sun J, Pedersen M, Bengtsson S, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "17904548", "url": "https://glygen.org/publication/PubMed/17904548" } ] }, { "title": "Cell-cell signaling via Eph receptors and ephrins.", "journal": "Current opinion in cell biology", "date": "2007", "authors": "Himanen JP, Saha N, Nikolov DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "17928214", "url": "https://glygen.org/publication/PubMed/17928214" } ] }, { "title": "FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions.", "journal": "Infection and immunity", "date": "2008", "authors": "Thomas BN, Buxbaum LU", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "18070890", "url": "https://glygen.org/publication/PubMed/18070890" } ] }, { "title": "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.", "journal": "Cell", "date": "2007", "authors": "Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" } ] }, { "title": "FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.", "journal": "Bone", "date": "2008", "authors": "Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "18374639", "url": "https://glygen.org/publication/PubMed/18374639" } ] }, { "title": "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.", "journal": "Science (New York, N.Y.)", "date": "2008", "authors": "Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D, Hollenbaugh D, Linnemann T, Qin M, Wong J, Chu K, Doberstein SK, Williams LT", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "18467591", "url": "https://glygen.org/publication/PubMed/18467591" } ] }, { "title": "Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity.", "journal": "Developmental cell", "date": "2008", "authors": "Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "18477452", "url": "https://glygen.org/publication/PubMed/18477452" } ] }, { "title": "Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases.", "journal": "The FEBS journal", "date": "2008", "authors": "Martin NG, McAndrew PC, Eve PD, Garrett MD", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "18479465", "url": "https://glygen.org/publication/PubMed/18479465" } ] }, { "title": "Adaptor protein Lnk associates with Tyr(568) in c-Kit.", "journal": "The Biochemical journal", "date": "2008", "authors": "Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "18588518", "url": "https://glygen.org/publication/PubMed/18588518" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Molecular cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Sun J, Pedersen M, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "18697750", "url": "https://glygen.org/publication/PubMed/18697750" } ] }, { "title": "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.", "journal": "Journal of proteome research", "date": "2008", "authors": "Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" } ] }, { "title": "Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Lin KT, Sloniowski S, Ethell DW, Ethell IM", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "18713744", "url": "https://glygen.org/publication/PubMed/18713744" } ] }, { "title": "System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.", "journal": "Chemistry & biology", "date": "2008", "authors": "Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "18721752", "url": "https://glygen.org/publication/PubMed/18721752" } ] }, { "title": "Molecular mechanism of the Syk activation switch.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "18818202", "url": "https://glygen.org/publication/PubMed/18818202" } ] }, { "title": "Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.", "journal": "J. Cell Sci.", "date": "2009", "authors": "Sato Izumi, Obata Yuuki, Kasahara Kousuke, Nakayama Yuji, Fukumoto Yasunori, Yamasaki Takahito, Yokoyama Kazunari K, Saito Takashi, Yamaguchi Naoto", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "19258394", "url": "https://glygen.org/publication/PubMed/19258394" } ] }, { "title": "The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Sun J, Pedersen M, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "19265199", "url": "https://glygen.org/publication/PubMed/19265199" } ] }, { "title": "Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.", "journal": "The Journal of biological chemistry", "date": "2009-05-08", "authors": "Varrin-Doyer Michel, Vincent Peggy, Cavagna Sylvie, Auvergnon Nathalie, Noraz Nelly, Rogemond V\u00e9ronique, Honnorat J\u00e9r\u00f4me, Moradi-Am\u00e9li Mahnaz, Giraudon Pascale", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "19276087", "url": "https://glygen.org/publication/PubMed/19276087" } ] }, { "title": "Large-scale proteomics analysis of the human kinome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" } ] }, { "title": "Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2009", "authors": "Baniwal SK, Khalid O, Sir D, Buchanan G, Coetzee GA, Frenkel B", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "19389811", "url": "https://glygen.org/publication/PubMed/19389811" } ] }, { "title": "Structure-Function analysis of the CTLA-4 interaction with PP2A.", "journal": "BMC immunology", "date": "2009", "authors": "Teft WA, Chau TA, Madrenas J", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "19405949", "url": "https://glygen.org/publication/PubMed/19405949" } ] }, { "title": "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.", "journal": "EMBO reports", "date": "2009", "authors": "Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "19525919", "url": "https://glygen.org/publication/PubMed/19525919" } ] }, { "title": "Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2009", "authors": "Shi Y, Pontrello CG, DeFea KA, Reichardt LF, Ethell IM", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "19553453", "url": "https://glygen.org/publication/PubMed/19553453" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function.", "journal": "Cell", "date": "1990", "authors": "Wada T, Qian XL, Greene MI", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "1973074", "url": "https://glygen.org/publication/PubMed/1973074" } ] }, { "title": "Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.", "journal": "Molecular biology of the cell", "date": "2009", "authors": "Park H, Cox D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "19741094", "url": "https://glygen.org/publication/PubMed/19741094" } ] }, { "title": "Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Ge C, Xiao G, Jiang D, Yang Q, Hatch NE, Roca H, Franceschi RT", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "19801668", "url": "https://glygen.org/publication/PubMed/19801668" } ] }, { "title": "c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes.", "journal": "Oncogene", "date": "2010", "authors": "Monsel G, Ortonne N, Bagot M, Bensussan A, Dumaz N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "19802003", "url": "https://glygen.org/publication/PubMed/19802003" } ] }, { "title": "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.", "journal": "BMC Immunol.", "date": "2009", "authors": "Voss M, Lettau M, Janssen O", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "19807924", "url": "https://glygen.org/publication/PubMed/19807924" } ] }, { "title": "A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis.", "journal": "Molecular biology of the cell", "date": "2010", "authors": "Beemiller P, Zhang Y, Mohan S, Levinsohn E, Gaeta I, Hoppe AD, Swanson JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "19955216", "url": "https://glygen.org/publication/PubMed/19955216" } ] }, { "title": "Distribution of c-yes-1 gene product in various cells and tissues.", "journal": "Br. J. Cancer", "date": "1991", "authors": "Sugawara K, Sugawara I, Sukegawa J, Akatsuka T, Yamamoto T, Morita M, Mori S, Toyoshima K", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "2021534", "url": "https://glygen.org/publication/PubMed/2021534" } ] }, { "title": "Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Helin K, Beguinot L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "2022652", "url": "https://glygen.org/publication/PubMed/2022652" } ] }, { "title": "Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2010", "authors": "Argetsinger LS, Stuckey JA, Robertson SA, Koleva RI, Cline JM, Marto JA, Myers MG Jr, Carter-Su C", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "20304997", "url": "https://glygen.org/publication/PubMed/20304997" } ] }, { "title": "Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2010", "authors": "Kelly EK, Wang L, Ivashkiv LB", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "20400701", "url": "https://glygen.org/publication/PubMed/20400701" } ] }, { "title": "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.", "journal": "Cell death and differentiation", "date": "2010", "authors": "Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M, Motoyoshi K, Kimura F, Okada S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "20489731", "url": "https://glygen.org/publication/PubMed/20489731" } ] }, { "title": "EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.", "journal": "Molecules and cells", "date": "2010", "authors": "Yoo S, Shin J, Park S", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665" } ], "reference": [ { "type": "PubMed", "id": "20496116", "url": "https://glygen.org/publication/PubMed/20496116" } ] }, { "title": "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis.", "journal": "Oncogene", "date": "1991", "authors": "Krueger J, Zhao Y H, Murphy D, Sudol M", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "2067846", "url": "https://glygen.org/publication/PubMed/2067846" } ] }, { "title": "Rb regulates fate choice and lineage commitment in vivo.", "journal": "Nature", "date": "2010", "authors": "Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "20686481", "url": "https://glygen.org/publication/PubMed/20686481" } ] }, { "title": "Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.", "journal": "The Journal of clinical investigation", "date": "2010", "authors": "Nishikawa K, Nakashima T, Takeda S, Isogai M, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen MJ, Takahashi S, Takayanagi H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "20877012", "url": "https://glygen.org/publication/PubMed/20877012" } ] }, { "title": "ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.", "journal": "Nature", "date": "2010", "authors": "Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, Fletcher JA, Dewell S, Maki RG, Zheng D, Antonescu CR, Allis CD, Sawyers CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "20927104", "url": "https://glygen.org/publication/PubMed/20927104" } ] }, { "title": "IgG1 is pathogenic in Leishmania mexicana infection.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2010", "authors": "Chu N, Thomas BN, Patel SR, Buxbaum LU", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "21037092", "url": "https://glygen.org/publication/PubMed/21037092" } ] }, { "title": "Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.", "journal": "PloS one", "date": "2010", "authors": "Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "21049007", "url": "https://glygen.org/publication/PubMed/21049007" } ] }, { "title": "Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity.", "journal": "The Journal of cell biology", "date": "2010", "authors": "Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, Toben D, Duda G, Atfi A, Geoffroy V, Horne WC, Baron R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "21173110", "url": "https://glygen.org/publication/PubMed/21173110" } ] }, { "title": "Clues for c-Yes involvement in the cell cycle and cytokinesis.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2011-05-01", "authors": "Jung Jessica, Lee Marie-Katrina, Jin Yan, Fu Song-Bin, Rosales Jesusa L, Lee Ki-Young", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "21566460", "url": "https://glygen.org/publication/PubMed/21566460" } ] }, { "title": "The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.", "journal": "PLoS biology", "date": "2011-06", "authors": "Tauzin S\u00e9bastien, Chaigne-Delalande Benjamin, Selva Eric, Khadra Nadine, Daburon Sophie, Contin-Bordes C\u00e9cile, Blanco Patrick, Le Seyec Jacques, Ducret Thomas, Counillon Laurent, Moreau Jean-Fran\u00e7ois, Hofman Paul, Vacher Pierre, Legembre Patrick", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "21713032", "url": "https://glygen.org/publication/PubMed/21713032" } ] }, { "title": "Colony-stimulating factor 1 activates protein kinase C in human monocytes.", "journal": "The EMBO journal", "date": "1990", "authors": "Imamura K, Dianoux A, Nakamura T, Kufe D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "2196173", "url": "https://glygen.org/publication/PubMed/2196173" } ] }, { "title": "Suppression of c-ras transformation by GTPase-activating protein.", "journal": "Nature", "date": "1990", "authors": "Zhang K, DeClue JE, Vass WC, Papageorge AG, McCormick F, Lowy DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "2201922", "url": "https://glygen.org/publication/PubMed/2201922" } ] }, { "title": "Gastrointestinal stromal tumours: origin and molecular oncology.", "journal": "Nature reviews. Cancer", "date": "2011", "authors": "Corless CL, Barnett CM, Heinrich MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "22089421", "url": "https://glygen.org/publication/PubMed/22089421" } ] }, { "title": "Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.", "journal": "Structure (London, England : 1993)", "date": "2011", "authors": "Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "22153499", "url": "https://glygen.org/publication/PubMed/22153499" } ] }, { "title": "Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.", "journal": "Structure (London, England : 1993)", "date": "2012", "authors": "Ma X, Lin WY, Chen Y, Stawicki S, Mukhyala K, Wu Y, Martin F, Bazan JF, Starovasnik MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "22483114", "url": "https://glygen.org/publication/PubMed/22483114" } ] }, { "title": "Stem cell factor receptor/c-Kit: from basic science to clinical implications.", "journal": "Physiological reviews", "date": "2012", "authors": "Lennartsson J, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "23073628", "url": "https://glygen.org/publication/PubMed/23073628" } ] }, { "title": "Leishmania mexicana infection induces IgG to parasite surface glycoinositol phospholipids that can induce IL-10 in mice and humans.", "journal": "PLoS neglected tropical diseases", "date": "2013", "authors": "Buxbaum LU", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "23675550", "url": "https://glygen.org/publication/PubMed/23675550" } ] }, { "title": "Characterization of cDNA clones for the human c-yes gene.", "journal": "Mol. Cell. Biol.", "date": "1987", "authors": "Sukegawa J, Semba K, Yamanashi Y, Nishizawa M, Miyajima N, Yamamoto T, Toyoshima K", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "2436037", "url": "https://glygen.org/publication/PubMed/2436037" } ] }, { "title": "KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation.", "journal": "Journal of clinical oncology : official journal of the American Society of Clinical Oncology", "date": "2015", "authors": "Serrano C, Wang Y, Marino-Enriquez A, Lee JC, Ravegnini G, Morgan JA, Bertagnolli MM, Beadling C, Demetri GD, Corless CL, Heinrich MC, Fletcher JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "24687822", "url": "https://glygen.org/publication/PubMed/24687822" } ] }, { "title": "Human Fc gamma RIII (CD16). Isoforms with distinct allelic expression, extracellular domains, and membrane linkages on polymorphonuclear and natural killer cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1989", "authors": "Edberg JC, Redecha PB, Salmon JE, Kimberly RP", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "2474607", "url": "https://glygen.org/publication/PubMed/2474607" } ] }, { "title": "CSF-1 receptor signaling in myeloid cells.", "journal": "Cold Spring Harbor perspectives in biology", "date": "2014", "authors": "Stanley ER, Chitu V", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "24890514", "url": "https://glygen.org/publication/PubMed/24890514" } ] }, { "title": "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2014", "authors": "Garner AP, Gozgit JM, Anjum R, Vodala S, Schrock A, Zhou T, Serrano C, Eilers G, Zhu M, Ketzer J, Wardwell S, Ning Y, Song Y, Kohlmann A, Wang F, Clackson T, Heinrich MC, Fletcher JA, Bauer S, Rivera VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "25239608", "url": "https://glygen.org/publication/PubMed/25239608" } ] }, { "title": "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.", "journal": "The Journal of experimental medicine", "date": "1989", "authors": "Brooks DG, Qiu WQ, Luster AD, Ravetch JV", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "2529342", "url": "https://glygen.org/publication/PubMed/2529342" } ] }, { "title": "All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Margolis BL, Lax I, Kris R, Dombalagian M, Honegger AM, Howk R, Givol D, Ullrich A, Schlessinger J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "2543678", "url": "https://glygen.org/publication/PubMed/2543678" } ] }, { "title": "Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth.", "journal": "Cancer discovery", "date": "2015", "authors": "Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "25572173", "url": "https://glygen.org/publication/PubMed/25572173" } ] }, { "title": "A gp130-Src-YAP module links inflammation to epithelial regeneration.", "journal": "Nature", "date": "2015", "authors": "Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "25731159", "url": "https://glygen.org/publication/PubMed/25731159" } ] }, { "title": "Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation.", "journal": "Osteoarthritis and cartilage", "date": "2015", "authors": "Lee YJ, Park SY, Lee SJ, Boo YC, Choi JY, Kim JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "25865393", "url": "https://glygen.org/publication/PubMed/25865393" } ] }, { "title": "The PRKAA1/AMPKalpha1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.", "journal": "Autophagy", "date": "2015", "authors": "Obba S, Hizir Z, Boyer L, Selimoglu-Buet D, Pfeifer A, Michel G, Hamouda MA, Goncalves D, Cerezo M, Marchetti S, Rocchi S, Droin N, Cluzeau T, Robert G, Luciano F, Robaye B, Foretz M, Viollet B, Legros L, Solary E, Auberger P, Jacquel A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "26029847", "url": "https://glygen.org/publication/PubMed/26029847" } ] }, { "title": "IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2015", "authors": "Sanin DE, Prendergast CT, Mountford AP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "26116503", "url": "https://glygen.org/publication/PubMed/26116503" } ] }, { "title": "Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.", "journal": "Structure (London, England : 1993)", "date": "2015", "authors": "Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "26235028", "url": "https://glygen.org/publication/PubMed/26235028" } ] }, { "title": "Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.", "journal": "Cell", "date": "2016", "authors": "Karsenty G, Olson EN", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "26967290", "url": "https://glygen.org/publication/PubMed/26967290" } ] }, { "title": "A phosphotyrosine switch regulates organic cation transporters.", "journal": "Nature communications", "date": "2016-03-16", "authors": "Sprowl Jason A, Ong Su Sien, Gibson Alice A, Hu Shuiying, Du Guoqing, Lin Wenwei, Li Lie, Bharill Shashank, Ness Rachel A, Stecula Adrian, Offer Steven M, Diasio Robert B, Nies Anne T, Schwab Matthias, Cavaletti Guido, Schlatter Eberhard, Ciarimboli Giuliano, Schellens Jan H M, Isacoff Ehud Y, Sali Andrej, Chen Taosheng, Baker Sharyn D, Sparreboom Alex, Pabla Navjotsingh", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "26979622", "url": "https://glygen.org/publication/PubMed/26979622" } ] }, { "title": "Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells.", "journal": "Drug design, development and therapy", "date": "2016", "authors": "Abbaspour Babaei M, Kamalidehghan B, Saleem M, Huri HZ, Ahmadipour F", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "27536065", "url": "https://glygen.org/publication/PubMed/27536065" } ] }, { "title": "Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.", "journal": "The Journal of clinical investigation", "date": "2016", "authors": "Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "27797343", "url": "https://glygen.org/publication/PubMed/27797343" } ] }, { "title": "Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors.", "journal": "Oncogene", "date": "2017", "authors": "Obata Y, Horikawa K, Takahashi T, Akieda Y, Tsujimoto M, Fletcher JA, Esumi H, Nishida T, Abe R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "28192400", "url": "https://glygen.org/publication/PubMed/28192400" } ] }, { "title": "M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells.", "journal": "PloS one", "date": "2017", "authors": "Hara Y, Obata Y, Horikawa K, Tasaki Y, Suzuki K, Murata T, Shiina I, Abe R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "28403213", "url": "https://glygen.org/publication/PubMed/28403213" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P07947", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P07947" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2017", "authors": "Bosbach B, Rossi F, Yozgat Y, Loo J, Zhang JQ, Berrozpe G, Warpinski K, Ehlers I, Veach D, Kwok A, Manova K, Antonescu CR, DeMatteo RP, Besmer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "28923937", "url": "https://glygen.org/publication/PubMed/28923937" } ] }, { "title": "The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders.", "journal": "Pharmacological research", "date": "2018", "authors": "Roskoski R Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "29704617", "url": "https://glygen.org/publication/PubMed/29704617" } ] }, { "title": "Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases.", "journal": "Pharmacology & therapeutics", "date": "2018", "authors": "Klug LR, Kent JD, Heinrich MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "29964125", "url": "https://glygen.org/publication/PubMed/29964125" } ] }, { "title": "Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours.", "journal": "British journal of cancer", "date": "2019", "authors": "Serrano C, Marino-Enriquez A, Tao DL, Ketzer J, Eilers G, Zhu M, Yu C, Mannan AM, Rubin BP, Demetri GD, Raut CP, Presnell A, McKinley A, Heinrich MC, Czaplinski JT, Sicinska E, Bauer S, George S, Fletcher JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "30792533", "url": "https://glygen.org/publication/PubMed/30792533" } ] }, { "title": "Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.", "journal": "Cancer cell", "date": "2019", "authors": "Smith BD, Kaufman MD, Lu WP, Gupta A, Leary CB, Wise SC, Rutkoski TJ, Ahn YM, Al-Ani G, Bulfer SL, Caldwell TM, Chun L, Ensinger CL, Hood MM, McKinley A, Patt WC, Ruiz-Soto R, Su Y, Telikepalli H, Town A, Turner BA, Vogeti L, Vogeti S, Yates K, Janku F, Abdul Razak AR, Rosen O, Heinrich MC, Flynn DL", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "31085175", "url": "https://glygen.org/publication/PubMed/31085175" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P07947", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P07947" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.", "journal": "Investigative ophthalmology & visual science", "date": "2022", "authors": "Murphy R, Irnaten M, Hopkins A, O'Callaghan J, Stamer WD, Clark AF, Wallace D, O'Brien CJ", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" } ], "reference": [ { "type": "PubMed", "id": "35015027", "url": "https://glygen.org/publication/PubMed/35015027" } ] }, { "title": "YES1 Is a Druggable Oncogenic Target in SCLC.", "journal": "Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer", "date": "2022-12", "authors": "Redin Esther, Garrido-Martin Eva M, Valencia Karmele, Redrado Miriam, Solorzano Jose Luis, Carias Rafael, Echepare Mirari, Exposito Francisco, Serrano Diego, Ferrer Irene, Nunez-Buiza Angel, Garmendia Irati, Garc\u00eda-Pedrero Juana M, Gurpide Alfonso, Paz-Ares Luis, Politi Katerina, Montuenga Luis M, Calvo Alfonso", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" } ], "reference": [ { "type": "PubMed", "id": "35988891", "url": "https://glygen.org/publication/PubMed/35988891" } ] }, { "title": "Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.", "journal": "Respiratory research", "date": "2023-04-03", "authors": "Jin Mingming, Wang Yan, Zhou Dawei, Liu Wanchao, Han Ruodong, Chi Yongbin", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" } ], "reference": [ { "type": "PubMed", "id": "37009887", "url": "https://glygen.org/publication/PubMed/37009887" } ] }, { "title": "YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.", "journal": "Biomolecules", "date": "2023-06-06", "authors": "Barros Patr\u00edcia, Matos Ana M, Matos Paulo, Jordan Peter", "evidence": [ { "database": "RefSeq", "id": "NP_005424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005424" } ], "reference": [ { "type": "PubMed", "id": "37371529", "url": "https://glygen.org/publication/PubMed/37371529" } ] }, { "title": "Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.", "journal": "Oncogene", "date": "1995", "authors": "Ricci A, Lanfrancone L, Chiari R, Belardo G, Pertica C, Natali PG, Pelicci PG, Segatto O", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "7478576", "url": "https://glygen.org/publication/PubMed/7478576" } ] }, { "title": "Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells.", "journal": "Oncogene", "date": "1995", "authors": "Yao R, Cooper GM", "evidence": [ { "database": "Reactome", "id": "R-HSA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662" } ], "reference": [ { "type": "PubMed", "id": "7478585", "url": "https://glygen.org/publication/PubMed/7478585" } ] }, { "title": "Expression of the Kit and KitA receptor isoforms in human acute myelogenous leukemia.", "journal": "Blood", "date": "1994", "authors": "Piao X, Curtis JE, Minkin S, Minden MD, Bernstein A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "7506952", "url": "https://glygen.org/publication/PubMed/7506952" } ] }, { "title": "Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Serve H, Hsu YC, Besmer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "7509796", "url": "https://glygen.org/publication/PubMed/7509796" } ] }, { "title": "Clustering of the high affinity Fc receptor for immunoglobulin G (Fc gamma RI) results in phosphorylation of its associated gamma-chain.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Duchemin AM, Ernst LK, Anderson CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "7512959", "url": "https://glygen.org/publication/PubMed/7512959" } ] }, { "title": "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.", "journal": "Experimental hematology", "date": "1994", "authors": "Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "7516890", "url": "https://glygen.org/publication/PubMed/7516890" } ] }, { "title": "Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils.", "journal": "Biochemical and biophysical research communications", "date": "1994", "authors": "Dusi S, Donini M, Della Bianca V, Rossi F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "7517665", "url": "https://glygen.org/publication/PubMed/7517665" } ] }, { "title": "Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Blume-Jensen P, Ronnstrand L, Gout I, Waterfield MD, Heldin CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "7520444", "url": "https://glygen.org/publication/PubMed/7520444" } ] }, { "title": "Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis.", "journal": "Blood", "date": "1994", "authors": "Mitchell MA, Huang MM, Chien P, Indik ZK, Pan XQ, Schreiber AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "7521687", "url": "https://glygen.org/publication/PubMed/7521687" } ] }, { "title": "Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling.", "journal": "Blood", "date": "1994", "authors": "Durden DL, Liu YB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "7522622", "url": "https://glygen.org/publication/PubMed/7522622" } ] }, { "title": "The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "7523381", "url": "https://glygen.org/publication/PubMed/7523381" } ] }, { "title": "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Tang B, Mano H, Yi T, Ihle JN", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "7526158", "url": "https://glygen.org/publication/PubMed/7526158" } ] }, { "title": "Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.", "journal": "The Biochemical journal", "date": "1995", "authors": "Ghazizadeh S, Bolen JB, Fleit HB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "7530449", "url": "https://glygen.org/publication/PubMed/7530449" } ] }, { "title": "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Jhun BH, Rivnay B, Price D, Avraham H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "7536744", "url": "https://glygen.org/publication/PubMed/7536744" } ] }, { "title": "The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Odai H, Sasaki K, Iwamatsu A, Hanazono Y, Tanaka T, Mitani K, Yazaki Y, Hirai H", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "7537740", "url": "https://glygen.org/publication/PubMed/7537740" } ] }, { "title": "Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Blume-Jensen P, Wernstedt C, Heldin CH, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "7539802", "url": "https://glygen.org/publication/PubMed/7539802" } ] }, { "title": "Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs.", "journal": "International immunology", "date": "1995", "authors": "Platzer C, Meisel C, Vogt K, Platzer M, Volk HD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "7547677", "url": "https://glygen.org/publication/PubMed/7547677" } ] }, { "title": "Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.", "journal": "The EMBO journal", "date": "1995", "authors": "Wallasch C, Weiss FU, Niederfellner G, Jallal B, Issing W, Ullrich A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "7556068", "url": "https://glygen.org/publication/PubMed/7556068" } ] }, { "title": "Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995", "authors": "Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad KV, Kufe D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "7597091", "url": "https://glygen.org/publication/PubMed/7597091" } ] }, { "title": "Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "7680037", "url": "https://glygen.org/publication/PubMed/7680037" } ] }, { "title": "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.", "journal": "The EMBO journal", "date": "1993", "authors": "Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "7681396", "url": "https://glygen.org/publication/PubMed/7681396" } ] }, { "title": "Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.", "journal": "Molecular and cellular biology", "date": "1993", "authors": "Yi T, Ihle JN", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "7684496", "url": "https://glygen.org/publication/PubMed/7684496" } ] }, { "title": "c-Yes tyrosine kinase activity in human colon carcinoma.", "journal": "Oncogene", "date": "1993", "authors": "Park J, Meisler AI, Cartwright CA", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "7690925", "url": "https://glygen.org/publication/PubMed/7690925" } ] }, { "title": "Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms.", "journal": "Blood", "date": "1995", "authors": "Van den Herik-Oudijk IE, Capel PJ, van der Bruggen T, Van de Winkel JG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "7718892", "url": "https://glygen.org/publication/PubMed/7718892" } ] }, { "title": "Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Saleem A, Kharbanda S, Yuan ZM, Kufe D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "7737969", "url": "https://glygen.org/publication/PubMed/7737969" } ] }, { "title": "Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Ducy P, Karsenty G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "7891679", "url": "https://glygen.org/publication/PubMed/7891679" } ] }, { "title": "ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Tzahar E, Levkowitz G, Karunagaran D, Yi L, Peles E, Lavi S, Chang D, Liu N, Yayon A, Wen D, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "7929212", "url": "https://glygen.org/publication/PubMed/7929212" } ] }, { "title": "Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif.", "journal": "Biochem. J.", "date": "1994", "authors": "Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AI", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "7980442", "url": "https://glygen.org/publication/PubMed/7980442" } ] }, { "title": "Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera.", "journal": "The EMBO journal", "date": "1994", "authors": "Prigent SA, Gullick WJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "8026468", "url": "https://glygen.org/publication/PubMed/8026468" } ] }, { "title": "Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Kiener PA, Rankin BM, Burkhardt AL, Schieven GL, Gilliland LK, Rowley RB, Bolen JB, Ledbetter JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "8226994", "url": "https://glygen.org/publication/PubMed/8226994" } ] }, { "title": "Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1993", "authors": "Ernst LK, Duchemin AM, Anderson CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "8327478", "url": "https://glygen.org/publication/PubMed/8327478" } ] }, { "title": "Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Agarwal A, Salem P, Robbins KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "8340414", "url": "https://glygen.org/publication/PubMed/8340414" } ] }, { "title": "Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain.", "journal": "Molecular and cellular biology", "date": "1993", "authors": "Wang ZE, Myles GM, Brandt CS, Lioubin MN, Rohrschneider L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "8355686", "url": "https://glygen.org/publication/PubMed/8355686" } ] }, { "title": "The molecular dissection of Fc gamma receptor mediated phagocytosis.", "journal": "Blood", "date": "1995", "authors": "Indik ZK, Park JG, Hunter S, Schreiber AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "8541526", "url": "https://glygen.org/publication/PubMed/8541526" } ] }, { "title": "Interactions of CD80 and CD86 with CD28 and CTLA4.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1996", "authors": "Ellis JH, Burden MN, Vinogradov DV, Linge C, Crowe JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356" } ], "reference": [ { "type": "PubMed", "id": "8609386", "url": "https://glygen.org/publication/PubMed/8609386" } ] }, { "title": "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.", "journal": "Blood", "date": "1996", "authors": "van Vugt MJ, Heijnen IA, Capel PJ, Park SY, Ra C, Saito T, Verbeek JS, van de Winkel JG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "8611682", "url": "https://glygen.org/publication/PubMed/8611682" } ] }, { "title": "JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.", "journal": "Blood", "date": "1996", "authors": "Weiler SR, Mou S, DeBerry CS, Keller JR, Ruscetti FW, Ferris DK, Longo DL, Linnekin D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8611693", "url": "https://glygen.org/publication/PubMed/8611693" } ] }, { "title": "ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.", "journal": "The EMBO journal", "date": "1996", "authors": "Karunagaran D, Tzahar E, Beerli RR, Chen X, Graus-Porta D, Ratzkin BJ, Seger R, Hynes NE, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "8617201", "url": "https://glygen.org/publication/PubMed/8617201" } ] }, { "title": "HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Cohen BD, Green JM, Foy L, Fell HP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "8617750", "url": "https://glygen.org/publication/PubMed/8617750" } ] }, { "title": "Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "8626543", "url": "https://glygen.org/publication/PubMed/8626543" } ] }, { "title": "Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Philo JS, Wen J, Wypych J, Schwartz MG, Mendiaz EA, Langley KE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8636116", "url": "https://glygen.org/publication/PubMed/8636116" } ] }, { "title": "Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.", "journal": "Science (New York, N.Y.)", "date": "1996-05-24", "authors": "Mareng\u00e8re L E, Waterhouse P, Duncan G S, Mittr\u00fccker H W, Feng G S, Mak T W", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "8638161", "url": "https://glygen.org/publication/PubMed/8638161" } ] }, { "title": "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8647802", "url": "https://glygen.org/publication/PubMed/8647802" } ] }, { "title": "Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.", "journal": "Molecular immunology", "date": "1996", "authors": "Truneh A, Reddy M, Ryan P, Lyn SD, Eichman C, Couez D, Hurle MR, Sekaly RP, Olive D, Sweet R", "evidence": [ { "database": "Reactome", "id": "R-HSA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356" } ], "reference": [ { "type": "PubMed", "id": "8649453", "url": "https://glygen.org/publication/PubMed/8649453" } ] }, { "title": "The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.", "journal": "Oncogene", "date": "1996", "authors": "Andoniou CE, Thien CB, Langdon WY", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "8649859", "url": "https://glygen.org/publication/PubMed/8649859" } ] }, { "title": "Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Law CL, Chandran KA, Sidorenko SP, Clark EA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "8657103", "url": "https://glygen.org/publication/PubMed/8657103" } ] }, { "title": "Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.", "journal": "The EMBO journal", "date": "1996", "authors": "Pinkas-Kramarski R, Soussan L, Waterman H, Levkowitz G, Alroy I, Klapper L, Lavi S, Seger R, Ratzkin BJ, Sela M, Yarden Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986" } ], "reference": [ { "type": "PubMed", "id": "8665853", "url": "https://glygen.org/publication/PubMed/8665853" } ] }, { "title": "Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody.", "journal": "Blood", "date": "1996", "authors": "Matous JV, Langley K, Kaushansky K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8695790", "url": "https://glygen.org/publication/PubMed/8695790" } ] }, { "title": "Epitope mapping and immunoneutralization of recombinant human stem-cell factor.", "journal": "European journal of biochemistry", "date": "1996", "authors": "Mendiaz EA, Chang DG, Boone TC, Grant JR, Wypych J, Aguero B, Egrie JC, Langley KE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8774734", "url": "https://glygen.org/publication/PubMed/8774734" } ] }, { "title": "Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.", "journal": "The Biochemical journal", "date": "1996", "authors": "Xu X, Chong AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "8809042", "url": "https://glygen.org/publication/PubMed/8809042" } ] }, { "title": "Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.", "journal": "Molecular biology of the cell", "date": "1996", "authors": "Matsuda M, Park JG, Wang DC, Hunter S, Chien P, Schreiber AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "8862523", "url": "https://glygen.org/publication/PubMed/8862523" } ] }, { "title": "Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion.", "journal": "Tissue antigens", "date": "1996", "authors": "Teng JM, King PD, Sadra A, Liu X, Han A, Selvakumar A, August A, Dupont B", "evidence": [ { "database": "Reactome", "id": "R-HSA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356" } ], "reference": [ { "type": "PubMed", "id": "8946678", "url": "https://glygen.org/publication/PubMed/8946678" } ] }, { "title": "Discrete protein interactions with the Grb2/c-Cbl complex in SCF- and TPO-mediated myeloid cell proliferation.", "journal": "Oncogene", "date": "1996", "authors": "Brizzi MF, Dentelli P, Lanfrancone L, Rosso A, Pelicci PG, Pegoraro L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8950973", "url": "https://glygen.org/publication/PubMed/8950973" } ] }, { "title": "Growth and differentiation signals regulated by the M-CSF receptor.", "journal": "Molecular reproduction and development", "date": "1997", "authors": "Rohrschneider LR, Bourette RP, Lioubin MN, Algate PA, Myles GM, Carlberg K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "8981370", "url": "https://glygen.org/publication/PubMed/8981370" } ] }, { "title": "Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.", "journal": "Immunity", "date": "1996", "authors": "Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "8986718", "url": "https://glygen.org/publication/PubMed/8986718" } ] }, { "title": "Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.", "journal": "Nature", "date": "1997", "authors": "Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "8990121", "url": "https://glygen.org/publication/PubMed/8990121" } ] }, { "title": "Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Anderson SM, Burton EA, Koch BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "8995358", "url": "https://glygen.org/publication/PubMed/8995358" } ] }, { "title": "Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.", "journal": "FEBS letters", "date": "1997", "authors": "Strzelecka A, Kwiatkowska K, Sobota A", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "9000504", "url": "https://glygen.org/publication/PubMed/9000504" } ] }, { "title": "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9038210", "url": "https://glygen.org/publication/PubMed/9038210" } ] }, { "title": "Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk.", "journal": "Biochimica et biophysica acta", "date": "1997", "authors": "Furlong MT, Mahrenholz AM, Kim KH, Ashendel CL, Harrison ML, Geahlen RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "9042338", "url": "https://glygen.org/publication/PubMed/9042338" } ] }, { "title": "Kit receptor dimerization is driven by bivalent binding of stem cell factor.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9045650", "url": "https://glygen.org/publication/PubMed/9045650" } ] }, { "title": "syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "El-Hillal O, Kurosaki T, Yamamura H, Kinet JP, Scharenberg AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "9050880", "url": "https://glygen.org/publication/PubMed/9050880" } ] }, { "title": "The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Jackson DE, Ward CM, Wang R, Newman PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990" } ], "reference": [ { "type": "PubMed", "id": "9054388", "url": "https://glygen.org/publication/PubMed/9054388" } ] }, { "title": "Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes.", "journal": "Journal of biochemistry", "date": "1997", "authors": "Ariki M, Tanabe O, Usui H, Hayashi H, Inoue R, Nishito Y, Kagamiyama H, Takeda M", "evidence": [ { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "9058199", "url": "https://glygen.org/publication/PubMed/9058199" } ] }, { "title": "Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.", "journal": "Molecular and cellular biology", "date": "1997", "authors": "Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, Ihle JN", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9111318", "url": "https://glygen.org/publication/PubMed/9111318" } ] }, { "title": "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence.", "journal": "Immunogenetics", "date": "1997", "authors": "Eskdale J, Kube D, Tesch H, Gallagher G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "9162098", "url": "https://glygen.org/publication/PubMed/9162098" } ] }, { "title": "Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.", "journal": "Cell", "date": "1997", "authors": "Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8940973", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973" } ], "reference": [ { "type": "PubMed", "id": "9182762", "url": "https://glygen.org/publication/PubMed/9182762" } ] }, { "title": "Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1997", "authors": "Marengere LE, Mirtsos C, Kozieradzki I, Veillette A, Mak TW, Penninger JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "9200440", "url": "https://glygen.org/publication/PubMed/9200440" } ] }, { "title": "Bryostatin 1 (bryo1)-induced monocytic differentiation in THP-1 human leukemia cells is associated with enhanced c-fyn tyrosine kinase and M-CSF receptors.", "journal": "Leukemia research", "date": "1997", "authors": "Li Y, Mohammad RM, al-Katib A, Varterasian ML, Chen B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9680350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350" } ], "reference": [ { "type": "PubMed", "id": "9225065", "url": "https://glygen.org/publication/PubMed/9225065" } ] }, { "title": "Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Newton JP, Buckley CD, Jones EY, Simmons DL", "evidence": [ { "database": "Reactome", "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990" } ], "reference": [ { "type": "PubMed", "id": "9252369", "url": "https://glygen.org/publication/PubMed/9252369" } ] }, { "title": "Chymase cleavage of stem cell factor yields a bioactive, soluble product.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Longley BJ, Tyrrell L, Ma Y, Williams DA, Halaban R, Langley K, Lu HS, Schechter NM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9256427", "url": "https://glygen.org/publication/PubMed/9256427" } ] }, { "title": "Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "1997", "authors": "Hunter S, Koch BL, Anderson SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "9259313", "url": "https://glygen.org/publication/PubMed/9259313" } ] }, { "title": "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.", "journal": "Archives of biochemistry and biophysics", "date": "1997", "authors": "Sun G, Budde RJ", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "reference": [ { "type": "PubMed", "id": "9281320", "url": "https://glygen.org/publication/PubMed/9281320" } ] }, { "title": "A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.", "journal": "The Journal of experimental medicine", "date": "1997", "authors": "Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481" } ], "reference": [ { "type": "PubMed", "id": "9314552", "url": "https://glygen.org/publication/PubMed/9314552" } ] }, { "title": "Stat1 associates with c-kit and is activated in response to stem cell factor.", "journal": "The Biochemical journal", "date": "1997", "authors": "Deberry C, Mou S, Linnekin D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9355737", "url": "https://glygen.org/publication/PubMed/9355737" } ] }, { "title": "Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.", "journal": "Science (New York, N.Y.)", "date": "1998", "authors": "Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "9438854", "url": "https://glygen.org/publication/PubMed/9438854" } ] }, { "title": "Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer.", "journal": "Blood", "date": "1998", "authors": "Broudy VC, Lin NL, Buhring HJ, Komatsu N, Kavanagh TJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9446650", "url": "https://glygen.org/publication/PubMed/9446650" } ] }, { "title": "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.", "journal": "Genes & development", "date": "1998", "authors": "Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO", "evidence": [ { "database": "Reactome", "id": "R-HSA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334" } ], "reference": [ { "type": "PubMed", "id": "9499402", "url": "https://glygen.org/publication/PubMed/9499402" } ] }, { "title": "Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Feshchenko EA, Langdon WY, Tsygankov AY", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "9525940", "url": "https://glygen.org/publication/PubMed/9525940" } ] }, { "title": "SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559" } ], "reference": [ { "type": "PubMed", "id": "9528781", "url": "https://glygen.org/publication/PubMed/9528781" } ] }, { "title": "CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1998", "authors": "Park RK, Kyono WT, Liu Y, Durden DL", "evidence": [ { "database": "Reactome", "id": "R-HSA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631" } ], "reference": [ { "type": "PubMed", "id": "9590251", "url": "https://glygen.org/publication/PubMed/9590251" } ] }, { "title": "Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).", "journal": "Biochemical and biophysical research communications", "date": "1998", "authors": "Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T", "evidence": [ { "database": "Reactome", "id": "R-HSA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513" } ], "reference": [ { "type": "PubMed", "id": "9712716", "url": "https://glygen.org/publication/PubMed/9712716" } ] }, { "title": "Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Hua CT, Gamble JR, Vadas MA, Jackson DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990" } ], "reference": [ { "type": "PubMed", "id": "9774457", "url": "https://glygen.org/publication/PubMed/9774457" } ] }, { "title": "Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1.", "journal": "Cancer research", "date": "1998", "authors": "Krystal GW, DeBerry CS, Linnekin D, Litz J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9670439", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439" } ], "reference": [ { "type": "PubMed", "id": "9788619", "url": "https://glygen.org/publication/PubMed/9788619" } ] }, { "title": "Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.", "journal": "Oncogene", "date": "1998", "authors": "Sun G, Sharma AK, Budde RJ", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "iPTMnet", "id": "P07947", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07947" } ], "reference": [ { "type": "PubMed", "id": "9794236", "url": "https://glygen.org/publication/PubMed/9794236" } ] }, { "title": "Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.", "journal": "The EMBO journal", "date": "1998", "authors": "Timokhina I, Kissel H, Stella G, Besmer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9799234", "url": "https://glygen.org/publication/PubMed/9799234" } ] }, { "title": "Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Lupher ML Jr, Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA, Druker B, Band H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "9857068", "url": "https://glygen.org/publication/PubMed/9857068" } ] }, { "title": "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.", "journal": "Oncogene", "date": "1998", "authors": "Liu SK, McGlade CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "9872323", "url": "https://glygen.org/publication/PubMed/9872323" } ] }, { "title": "EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family.", "journal": "FEBS letters", "date": "1998", "authors": "Callebaut I, Cossart P, Dehoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "9883880", "url": "https://glygen.org/publication/PubMed/9883880" } ] }, { "title": "A contractile activity that closes phagosomes in macrophages.", "journal": "Journal of cell science", "date": "1999", "authors": "Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422" } ], "reference": [ { "type": "PubMed", "id": "9885284", "url": "https://glygen.org/publication/PubMed/9885284" } ] }, { "title": "Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1999", "authors": "Sadra A, Cinek T, Arellano JL, Shi J, Truitt KE, Imboden JB", "evidence": [ { "database": "Reactome", "id": "R-HSA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356" } ], "reference": [ { "type": "PubMed", "id": "9973466", "url": "https://glygen.org/publication/PubMed/9973466" } ] } ], "pathway": [ { "id": "hsa:7525", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7525", "resource": "KEGG Pathway" }, { "id": "R-HSA-1227986", "name": "Signaling by ERBB2", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1227986", "resource": "Reactome", "description": "Signaling by ERBB2" }, { "id": "R-HSA-1433557", "name": "Signaling by SCF-KIT", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557", "resource": "Reactome", "description": "Signaling by SCF-KIT" }, { "id": "R-HSA-1433559", "name": "Regulation of KIT signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433559", "resource": "Reactome", "description": "Regulation of KIT signaling" }, { "id": "R-HSA-2029481", "name": "FCGR activation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481", "resource": "Reactome", "description": "FCGR activation" }, { "id": "R-HSA-210990", "name": "PECAM1 interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210990", "resource": "Reactome", "description": "PECAM1 interactions" }, { "id": "R-HSA-2682334", "name": "EPH-Ephrin signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682334", "resource": "Reactome", "description": "EPH-Ephrin signaling" }, { "id": "R-HSA-389356", "name": "CD28 co-stimulation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389356", "resource": "Reactome", "description": "CD28 co-stimulation" }, { "id": "R-HSA-389513", "name": "CTLA4 inhibitory signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389513", "resource": "Reactome", "description": "CTLA4 inhibitory signaling" }, { "id": "R-HSA-3928662", "name": "EPHB-mediated forward signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662", "resource": "Reactome", "description": "EPHB-mediated forward signaling" }, { "id": "R-HSA-3928663", "name": "EPHA-mediated growth cone collapse", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928663", "resource": "Reactome", "description": "EPHA-mediated growth cone collapse" }, { "id": "R-HSA-3928665", "name": "EPH-ephrin mediated repulsion of cells", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928665", "resource": "Reactome", "description": "EPH-ephrin mediated repulsion of cells" }, { "id": "R-HSA-8940973", "name": "RUNX2 regulates osteoblast differentiation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940973", "resource": "Reactome", "description": "RUNX2 regulates osteoblast differentiation" }, { "id": "R-HSA-912631", "name": "Regulation of signaling by CBL", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912631", "resource": "Reactome", "description": "Regulation of signaling by CBL" }, { "id": "R-HSA-9664323", "name": "FCGR3A-mediated IL10 synthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323", "resource": "Reactome", "description": "FCGR3A-mediated IL10 synthesis" }, { "id": "R-HSA-9664422", "name": "FCGR3A-mediated phagocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422", "resource": "Reactome", "description": "FCGR3A-mediated phagocytosis" }, { "id": "R-HSA-9670439", "name": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439", "resource": "Reactome", "description": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants" }, { "id": "R-HSA-9680350", "name": "Signaling by CSF1 (M-CSF) in myeloid cells", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350", "resource": "Reactome", "description": "Signaling by CSF1 (M-CSF) in myeloid cells" } ], "orthologs": [ { "uniprot_canonical_ac": "Q04736-1", "protein_name": "Tyrosine-protein kinase Yes", "gene_name": "Yes1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGCIKSKENKSPAIKYTPENLTEPVSPSASHYGVEHATVAPTSSTKGASVNFNSLSMTPFGGSSGVTPFGGASSSFSVVSSSYPTGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL", "length": 541 }, "evidence": [ { "id": "45919216", "url": "http://www.informatics.jax.org/homology/45919216", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response to antigenic stimulus", "id": "GO:0002862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002862", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "Fc-gamma receptor signaling pathway involved in phagocytosis", "id": "GO:0038096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038096", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "regulation of vascular permeability", "id": "GO:0043114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043114", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-tyrosine phosphorylation", "id": "GO:0050731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050731", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "leukocyte migration", "id": "GO:0050900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050900", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "cellular response to platelet-derived growth factor stimulus", "id": "GO:0036120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036120", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "regulation of glucose transmembrane transport", "id": "GO:0010827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010827", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "non-membrane spanning protein tyrosine kinase activity", "id": "GO:0004715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004715", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "extrinsic component of cytoplasmic side of plasma membrane", "id": "GO:0031234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031234", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.", "evidence": [ { "database": "UniProtKB", "id": "P07947", "url": "https://www.uniprot.org/uniprot/P07947" }, { "database": "PubMed", "id": "11901164", "url": "https://glygen.org/publication/PubMed/11901164" }, { "database": "PubMed", "id": "9794236", "url": "https://glygen.org/publication/PubMed/9794236" }, { "database": "PubMed", "id": "9281320", "url": "https://glygen.org/publication/PubMed/9281320" } ] } ], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WUD9-1", "P57760-1", "P35739-1", "F1LYY7-1", "A0A8I6GCV6-1", "Q63132-1", "Q63117-1", "Q5U2X5-1", "Q63474-1", "Q4V8A3-1", "O08680-1", "O35346-1", "P54757-1", "P54758-1", "P54759-1", "P70600-1", "Q00495-1", "Q03351-1", "Q04589-1", "P06494-1", "P09759-1", "P29321-1", "P32577-1", "Q6XUX2-1", "Q62662-1", "Q62799-1", "Q62844-1", "Q62956-1", "Q63184-1", "Q63470-1", "Q498D6-1", "Q01621-1", "Q6P6U0-1", "Q63604-1", "P09760-1", "Q01986-1", "Q62862-1", "Q63572-1", "Q07014-1", "Q4KSH7-1", "G3V9H8-1", "P15127-1", "O08775-1", "P53767-1", "Q05030-1", "P55146-1", "Q64725-1", "Q63802-1", "Q64716-1", "P09215-1", "Q62689-1", "F1LM93-1", "P36506-1", "P20786-1", "P24062-1", "Q924U5-1", "Q63272-1", "B2RYC7-1", "P41243-1", "M0RDA4-1", "Q62838-1", "Q63116-1", "A0A8I6AM23-1", "P50545-1", "P57097-1", "P97523-1", "Q91ZT1-1", "D4A7W7-1", "F1LVI0-1", "E9PSY0-1", "A0A0G2K6M9-1", "F1LSN4-1", "F1MAJ0-1", "A0A0R4J8U1-1", "A0A8I6A5T6-1", "D3ZDS3-1", "D4ADZ5-1", "F1LSG7-1", "F1LRZ0-1", "D3ZBN3-1", "F1M0N1-1", "G3V6K6-1", "D3ZD03-1", "D3ZZK3-1", "E9PT20-1", "D4A584-1", "D3ZDH4-1", "A0A8I5ZVE3-1", "A0A8I6AWX7-1", "Q4KM97-1", "Q501W1-1", "B5DFD6-1", "Q5FVG7-1", "D3ZCD0-1", "A0A8I5ZP97-1", "A0A0G2JW59-1", "B1WC09-1", "Q01134-1", "P11980-1", "G3V783-1", "D3ZJI4-1", "Q4KSH6-1", "M0R7E7-1", "Q925D6-1", "Q9UM73-1", "O15146-1", "P42679-1", "P08922-1", "P07947-1", "Q12866-1", "P00519-1", "Q07912-1", "P42684-1", "Q9UF33-1", "P10721-1", "P08069-1", "P06239-1", "P04626-1", "P51451-1", "Q06187-1", "P51813-1", "Q9UIG0-1", "P49760-1", "P49761-4", "Q9HAZ1-1", "P49759-1", "P07333-1", "Q5JZY3-1", "Q6XUX3-1", "P00533-1", "Q9Y463-1", "P29317-1", "Q9NR20-1", "Q13627-1", "P54760-1", "P41240-1", "Q16832-1", "Q15375-1", "P29323-1", "P22455-1", "P16591-1", "P29322-1", "P54756-1", "P29320-1", "Q08345-1", "Q92630-1", "P54753-1", "Q15303-1", "P21860-1", "Q14289-1", "O43781-1", "P54764-1", "P19525-1", "P21709-1", "P54762-1", "P22607-1", "P21802-1", "P52333-1", "P11362-1", "P42685-1", "P06213-1", "P14616-1", "Q05655-1", "Q08881-1", "P07332-1", "P08631-1", "P29376-1", "Q05397-1", "O60674-1", "P23458-1", "P36888-1", "P09769-1", "P06241-1", "P43405-1", "P07948-1", "P46734-1", "P45985-1", "Q02750-1", "P52564-1", "O14733-1", "Q13163-1", "Q16288-1", "P36507-1", "Q16620-1", "P08581-1", "P04629-1", "Q14680-1", "Q01974-1", "P09619-1", "P07949-1", "Q504Y2-1", "P34925-1", "P16234-1", "Q13882-1", "Q04912-1", "O43353-1", "Q06418-1", "P30530-1", "Q96KB5-1", "Q15569-1", "Q96S53-1", "Q6J9G0-1", "P42680-1", "P35916-2", "P0C1S8-1", "P17948-1", "P29597-1", "P42681-1", "P35590-1", "Q13470-1", "P33981-1", "P30291-1", "P12931-1", "P35968-1", "P43403-1", "O75716-1", "Q02763-1", "Q9H3Y6-1", "P35790-1", "P14618-1", "P24604-1", "Q9Z188-1", "P35969-1", "P52332-1", "P08923-1", "Q00342-1", "Q62120-1", "Q4JIM5-1", "P97504-1", "P42682-1", "Q60629-1", "O54967-1", "P00520-1", "P97793-1", "P16277-1", "O35491-1", "O35492-1", "O35493-1", "Q9Z277-1", "P35991-1", "P22518-1", "Q8BYG9-1", "P54754-1", "P54761-1", "Q6XUX1-1", "Q62371-1", "Q60750-1", "Q61527-1", "Q62413-1", "Q61214-1", "Q61772-1", "Q61851-1", "Q922Y0-1", "Q922K9-1", "O09127-1", "P16092-1", "Q03142-1", "P29319-1", "Q01279-1", "P70424-1", "P21803-1", "Q8CBF3-1", "P41241-1", "Q03963-1", "Q8BI55-1", "P54763-3", "P16879-1", "P09581-1", "P34152-3", "P14234-1", "P39688-1", "Q03146-1", "Q03145-1", "Q61526-1", "P70451-1", "Q5U4C9-1", "Q9QVP9-1", "Q03137-1", "Q60751-1", "Q62137-1", "P28867-1", "P25911-1", "P48025-1", "Q9WTL4-1", "P41242-1", "P05532-1", "P06240-1", "P08103-1", "P15208-1", "Q03526-1", "Q9WVS7-1", "P70236-1", "P31938-1", "P47809-1", "Q61846-1", "Q60805-1", "Q63932-1", "O09110-1", "P26618-1", "Q8CE90-1", "P16056-1", "P05622-1", "P15209-1", "Q6VNS1-1", "Q61006-1", "Q3UFB7-1", "Q5RJI4-1", "Q9JJ78-1", "P58801-1", "Q8VCT9-1", "O70146-1", "Q62190-1", "Q62270-1", "P35546-1", "P35761-1", "Q9Z138-1", "Q9R117-1", "O88697-1", "P05480-2", "Q01887-1", "Q02858-1", "Q06806-1", "Q00993-1", "Q64434-1", "Q6J9G1-1", "Q99ML2-1", "Q78DX7-1", "P55144-1", "P43404-1", "P35917-1", "P47810-1", "P35918-1", "Q04736-1", "Q66JT0-1", "O54804-1", "P52480-1", "P14680-1", "P21965-1", "P22216-1", "P32490-1", "P06784-1", "P08018-1", "P32350-1", "P32491-1", "P54199-1", "Q54G28-1", "Q54N73-1", "Q54R58-1", "P18160-1", "P18161-1", "Q54BC9-1", "Q54I36-1", "Q54QV3-1", "Q552C6-1", "Q55CL6-1", "Q75JK0-1", "Q76NV1-1", "Q23977-1", "P18475-1", "P13368-1", "Q24145-1", "Q24488-1", "Q27324-1", "P08630-1", "P00522-1", "P00528-1", "P04412-1", "Q9V422-1", "Q9V6K3-1", "Q9V9J3-1", "Q9VBW3-1", "P09208-1", "P49762-1", "P83102-1", "Q24324-1", "Q9VPC0-1", "P49657-1", "P54350-1", "P18106-4", "Q07407-1", "Q09147-1", "Q24592-1", "Q9I7F7-1", "Q9V3D5-1", "Q9VZI2-1", "Q8INJ8-1", "Q7KJ08-1", "Q9VJ04-1", "E1JHB7-1", "Q9VE06-1", "O61444-1", "O62602-1", "Q9VZA8-1", "Q7KT06-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-HSA-1433418", "name": "Phosphorylation of JAK2", "equation": "", "summary": "SCF induces rapid and transient autophosphorylation of JAK2 bound to c-KIT. JAKs bound to activated, dimerized receptors cross-phosphorylate and thereby activate each other. Multiple phosphorylation sites have been identified in JAK2 (tyrosines 221, 570, 868, 966, 972, 1007 and 1008 ). Phosphorylation of tyrosine 1007 is essential for kinase activity (Feng et al 1997, Argetsinger et al. 2004, 2010). Tyrosine 1007 is in the activation loop and phosphorylation allows access of the catalytic loop to the ATP in the ATP binding domain. Of all the predicted phoshorylation sites only the critical tyrosine 1007 is represented in the reaction.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1433418", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433418" } ] }, { "id": "R-HSA-1433428", "name": "GRB2 is indirectly recruited to p-KIT through SHP2", "equation": "", "summary": "GRB2 can be recruited indirectly to KIT through SHP2 (Tauchi et al. 1994). Y279, Y304, Y546 and Y584 (usually referred to as Y542 and Y580 in literature based on the SHP2 short isoform) are the potential sites of SHP2 tyrosyl phosphorylation and that Y546 is the major GRB2 binding site (Feng, et al. 1993, Araki, et al. 2003). This brings Grb2:SOS1 into proximity with the plasma membrane, where it can activate Ras.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-1433428", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433428" } ] }, { "id": "R-HSA-1433451", "name": "JAK2 binds to p-KIT", "equation": "", "summary": "Janus kinase 2 (JAK2) plays an important role in SCF-induced proliferation (Radosevic et al. 2004). JAK2 was observed to pre-associate with KIT, with increased association after SCF stimulation of KIT (Weiler et al. 1996).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1433451", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433451" } ] }, { "id": "R-HSA-1433454", "name": "Phosphorylation of GAB2 by SFKs", "equation": "", "summary": "GAB2 bound to GRB2 on KIT is then phosphorylated on a number of tyrosine residues through the action of Src family kinases (SFKs).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-1433454", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433454" } ] }, { "id": "R-HSA-1433456", "name": "Recruitment of STATs", "equation": "", "summary": "Activation of KIT mediates the recruitment of and association with STAT1alpha, STAT3, STAT5A and STAT5B (Deberry et al. 1997, Brizzi et al. 1999, R\u00f6nnstrand 2004).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1433456", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433456" } ] }, { "id": "R-HSA-1433488", "name": "Phosphorylation of SHP2 by SFKs", "equation": "", "summary": "Following association with KIT, Tauchi et al. had observed phosphorylation of SHP2 (Tauchi et al. 1994). Tyrosine residues Y546 and Y584 (usually referred to as Y542 and Y580 in literature based on the short isoform) are the major sites of SHP2 tyrosyl phosphorylation. Src family kinases (SFKs) are candidates for this phosphorylation (Araki et al. 2003). The phosphorylated tyrosine residues on SHP2 can recruit the adapter protein GRB2 (Tauchi et al. 1994), but it is unclear whether GRB2 binding to SHP2 is important for KIT mediated SHP2 signaling or whether the effect of SHP2 on the RAS/ERK pathway goes through its catalytic activity.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-1433488", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433488" } ] }, { "id": "R-HSA-1433506", "name": "Phosphorylation of APS", "equation": "", "summary": "APS bound to KIT is phosphorylated by tyrosine kinases in response to SCF stimulation (Wollberg et al, 2003). The C-terminal tyrosine 629 may be the target site of phosphorylation in APS (Wakioka et al, 1999).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1433506", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433506" } ] }, { "id": "R-HSA-1433514", "name": "Synthesis of PIP3 from PIP2 by PI3K", "equation": "", "summary": "PI3 kinases catalyze the production of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) by phosphorylating phosphatidylinositol-4, 5-bisphosphate (PIP2). PIP3 bound to the inner lipid bilayer of the plasma membrane promotes the recruitment and activation of AKT. Active AKT subsequently phosphorylates the pro-apoptotic factor BAD at Ser136. Phosphorylated BAD binds 14-3-3 proteins, sequestering BAD from interaction with the anti-apoptotic molecule BCL-XL and leaving BCL-Xl free to inhibit BAX-triggered apoptosis. In this way, AKT-mediated BAD phosphorylation promotes cell survival. The alternative route for c-Kit mediated survival is through AKT-mediated phosphorylation and inactivation of the forkhead transcription factor (FoxO3a) (Engstrom et al, 2003; Lennartson et al, 2005).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42336-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-1433514", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433514" } ] }, { "id": "R-HSA-1433542", "name": "Phosphorylation and activation of VAV1", "equation": "", "summary": "The Src and PI3-kinase signaling pathways converge to activate Rac1 and JNK after c-Kit activation, promoting mast cell proliferation but not for suppression of apoptosis (Timokhina et al. 1998). PI3K and Src are considered mediators of c-Kit induced Rac1 activation via the guanine nucleotide exchange factor (GEF) VAV1. Stimulation of c-Kit receptor results in rapid tyrosine phosphorylation of VAV1 (Timokhina et al. 1998).
VAV1 exists in an auto-inhibitory state folded in such a way as to inhibit the GEF activity of its Dbl homology domain (DH) domain. PI3K is thought to modulate the activation of VAV1 by influencing its degree of tyrosine phosphorylation and its recruitment to membrane. VAV1 is recruited to membrane by binding to PtdIns(3,4,5)P3 (PIP3) and this interaction relieves an intramolecular interaction between pleckstrin homology (PH) and DH domains, thus facilitating tyrosine phosphorylation on Y174 and so further opening of the DH/PH domains, binding of Rac-GDP and catalysis (Welch et al, 2003). In VAV1, tyrosine 174 (Y174) binds to the DH domain and inhibits its GEF activity. Src kinases phosphorylate this Y174 and this causes the tyrosine to move away from the DH domain thereby reliving the auto-inhibition.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [ "R-HSA-195066" ], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1433542", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433542" } ] }, { "id": "R-HSA-1470009", "name": "Phosphorylation of STATs", "equation": "", "summary": "JAK2 activation results in the phosphorylation and activation of STAT1alpha, STAT3, STAT5A and STAT5B (Deberry et al. 1997, Brizzi et al. 1999, Ning et al. 2001, Ronnstrand 2004). STAT family members can be activated by JAK kinases, receptor tyrosine kinases or SFKs. LYN kinase has been identified to have role in SCF-induced phosphorylation of STAT3 (Shivakrupa & Linnekin 2005).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1470009", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1470009" } ] }, { "id": "R-HSA-1470010", "name": "Dimerization of STATs", "equation": "", "summary": "Phosphorylation on tyrosine residues immediately distal to the SH2 domain induces STATs homo- or heterodimerization through phosphotyrosine-SH2 interactions.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1470010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1470010" } ] }, { "id": "R-HSA-1470012", "name": "Disassociation and translocation of STATs to the nucleus", "equation": "", "summary": "After dimerization STAT dimers release from the receptor complex and migrate to the nucleus for DNA binding. STAT5s/STAT1alpha heterodimeric complexes specifically recognize beta-casein promoter region (PIE) (Brizzi et al. 1999). c-Kit dependent JAK/STAT activation is associated with the growth and differentiation of fetal liver haematopoietic progenitor cells (R\u00f6nnstrand 2004, Reber et al. 2006).", "cellular_location": "cytosol, extracellular region, nucleoplasm, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1470012", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1470012" } ] }, { "id": "R-HSA-1472121", "name": "Phosphorylation of p-KIT on Y900 by Src kinases", "equation": "", "summary": "Src family of tyrosine kinases phosphorylate KIT on Y900 located in the second part of the tyrosine kinase domain. This phosphorylated tyrosine acts as a docking site for p85alpha regulatory subunit of PI3K and the adapter protein CRKII. CRKII does not interact directly with KIT but is recruited indirectly by binding to p85alpha subunit of PI3K. Thus, in this case the p85 subunit acts as an adapter between KIT and CRKII, and not to recruit PI3-kinase. (Lennartsson et al. 2003).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-1472121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1472121" } ] }, { "id": "R-HSA-1562641", "name": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2", "equation": "", "summary": "Phosphorylated GAB2 recruits the p85 subunit of the PI3K complex and activates the PI3K/AKT pathway. This is one of two mechanisms described for the recruitment of PI3K to KIT.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42336-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-1562641", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1562641" } ] }, { "id": "R-HSA-1963586", "name": "SRC family kinases phosphorylate ERBB2", "equation": "", "summary": "Dissociation of HSP90 from ERBB2 upon formation of ERBB2 heterodimers (with either EGFR, ERBB3 or ERBB4) enables phosphorylation of ERBB2 on the tyrosine residue Y877, mediated by one of SRC family kinases - SRC, FYN or YES1. Although not a mandatory prerequisite of ERBB2 catalytic activity, the phosphorylation at Y877 significantly increases the kinase activity of ERBB2.", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00533-1", "P04626-1", "P06241-1", "P12931-1", "P07947-1" ], "evidence": [ { "id": "R-HSA-1963586", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1963586" } ] }, { "id": "R-HSA-2029459", "name": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts", "equation": "", "summary": "After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P09769-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-2029459", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029459" } ] }, { "id": "R-HSA-205205", "name": "Interaction of Src family kinases with p-KIT", "equation": "", "summary": "Binding of SCF to KIT induces the activation and rapid increase in kinase activity of multiple Src family kinases (SFK), including Src, Lck, Tec, Fyn, and Lyn (Timokhina et al. 1998, Krystal et al. 1998, Linnekin et al. 1997, Lennartsson et al. 1999, Tang et al. 1994, Samayawardhena et al. 2007). The tyrosine residues Y568 and Y570 in KIT juxtamembrane region are involved in the association of SFKs (Price et al. 1997).
SFKs recruited to KIT induce proliferation and chemotaxis in primary hematopoietic progenitor cells or bone marrow derived mast cells (O'Laughlin-Bunner et al. 2001). SCF activated SFKs also mediate a critical signal for lymphocyte development (Agosti et al. 2004). Timokhina et al. demonstrated that Src kinase and PI3-kinase signaling pathways converge to activate Rac1 and JNK after SCF stimulation in BMMC, promoting cell proliferation (Timokhina et al., 1998, Reber et al. 2006 ).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-205205", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-205205" } ] }, { "id": "R-HSA-205234", "name": "Indirect recruitment of GAB2 to p-KIT", "equation": "", "summary": "The scaffolding adapter GAB2 plays a role in KIT dependent PI3K/AKT activation. GAB2 interacts with KIT indirectly via the adapter protein GRB2 which is bound to KIT on phosphorylated Y703 and Y936 (Sun et al. 2008, Yu et al. 2006).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-205234", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-205234" } ] }, { "id": "R-HSA-205238", "name": "SHP2 interacts with p-KIT", "equation": "", "summary": "SHP2 is a protein tyrosine phosphatase (PTP) with two NH2-terminal SH2 domains, a PTP domain, a -COOH tail with two tyrosyl phosphorylation sites at Y546 and Y584, and an interposed proline-rich domain. SHP2 binds to activated KIT on tyrosine-568 in the juxtamembrane region, which also constitutes the docking site for a number of other signal transduction molecules, such as SFKs, Csk homologous kinase (CHK), CBL, LNK and Adapter protein with PH and SH2 domains (APS) (Kozlowski et al. 1998, Price et al. 1997, Gueller et al. 2008).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-205238", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-205238" } ] }, { "id": "R-HSA-205244", "name": "Recruitment of CBL to KIT", "equation": "", "summary": "The phosphotyrosine residue in APS creates a putative binding site for CBL. CBL is an ubiquitin E3 ligase that attaches ubiquitin to KIT leading to KIT's ubiquitination followed by internalization and degradation. GRB2 in addition to its role in positive signaling via RAS/ERK pathway also mediates negative regulation of KIT by recruiting CBL (Sun et al, 2007). CBL has also been shown to bind directly to both Y568 and Y936 in KIT (Masson et al. 2006). CBL bound to KIT ubiquitinates KIT and targets it to lysosomal degradation (Masson et al. 2006)", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P22681-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-205244", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-205244" } ] }, { "id": "R-HSA-205319", "name": "Interaction of APS and p-KIT", "equation": "", "summary": "APS adapter protein has been identified as a KIT binding partner using yeast two-hybrid screening. APS contains a PH domain and an SH2 domain. The SH2 domain interacts with c-Kit phosphotyrosine residues Y568 and Y936 (Wollberg et al. 2003).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-205319", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-205319" } ] }, { "id": "R-HSA-210291", "name": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src", "equation": "", "summary": "PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-210291", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210291" } ] }, { "id": "R-HSA-388829", "name": "SHP2 phosphatase binds CTLA-4", "equation": "", "summary": "CTLA4 associates with the SH2 domain containing tyrosine phosphatase SHP2 and this interaction is mediated through the YVKM motif of CTLA-4. Phosphorylation of tyrosine in the YVKM motif recruits SHP-2.
Still the association of SHP-2 with CTLA-4 is unclear and remains controversial. Several other studies have reported that CTLA-4 does not directly associate with SHP-2. The interaction between the phosphatase and CTLA-4 may be an indirect event, possibly mediated by PI3-kinase/SHP-2 binding.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P06239-1", "P07947-1", "P07948-1", "Q06124-2" ], "evidence": [ { "id": "R-HSA-388829", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-388829" } ] }, { "id": "R-HSA-388831", "name": "Phosphorylation of CD28", "equation": "", "summary": "The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-388831", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-388831" } ] }, { "id": "R-HSA-388833", "name": "Phosphorylation of CTLA-4", "equation": "", "summary": "Upon TCR-CTLA-4 complex formation, CTLA4 is tyrosine phosphorylated. Src family tyrosine kinases Fyn, Lyn, and Lck associate with CTLA-4 and phosphorylate both Y-201 and Y-218 that are mainly responsible for interaction with Fyn through its SH2 domain (Marengere et al. 1996). Once tyrosine 165 is phosphorylated, PP2A is activated and disassociates from CTLA4; this correlates with T cell inactivation.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P67775-1", "P06239-1", "P07947-1", "P07948-1", "P62714-1" ], "evidence": [ { "id": "R-HSA-388833", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-388833" } ] }, { "id": "R-HSA-389159", "name": "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues", "equation": "", "summary": "Following dimerization of the CSF-1 receptor (CSF1R), it undergoes trans-autophosphorylation on multiple tyrosine residues by its intrinsic kinase activity (Rohrschneider et al. 1997, Chihara et al. 2010). Tyrosine-561 (tyrosine-559 in the mouse homolog) in the juxtamembrane domain inhibits the kinase activity of CSF1R and is phosphorylated first, thus activating the kinase activity of CSF1R (inferred from the mouse homolog). Other tyrosine residues that are autophosphorylated are tyrosine-546 in the juxtamembrane domain, tyrosines-699,708,723 in the kinase insert domain, tyrosine-809 in the kinase domain, and tyrosines-923,969 in the C-terminal domain (Chihara et al. 2010, reviewed in Hamilton 1997, and inferred from the mouse homolog).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P22681-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-389159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389159" } ] }, { "id": "R-HSA-3928583", "name": "FYN phosphorylates NMDAR2B", "equation": "", "summary": "Protein phosphorylation is an important mechanism modulating the function of NMDA receptors (NMDARs). SRC-family kinases that associate with EPHB are important for the phosphorylation of ionotropic glutamate receptor, NR2B (NMDAR2B, GRIN2B) Tyrosines 1252, 1336, and 1474 (1252, 1336, and 1472 in mouse) on NR2B are phosphorylated by FYN/SRC bound to EPHB2, thereby enhancing NMDA-dependent calcium influx upon glutamate stimulation (Takasu et al. 2002, Dalva et al. 2000). Tyrosine phosphorylation of NMDAR2B also regulates the surface expression of NMDARs. EPHB mediated phosphorylation of NMDARs can also increase the surface retention of NMDAR2B-containing NMDARs by preventing clathrin-dependent endocytosis. Phosphorylation at tyrosine 1474 (mouse Y1472) of NMDAR2B blocks binding of the mu2 subunit of clathrin adaptor protein 2 (AP2) complex thus preventing clathrin-dependent endocytosis (Chen & Roche 2007).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P29323-1", "P54760-1", "P54753-1", "P54762-1" ], "evidence": [ { "id": "R-HSA-3928583", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928583" } ] }, { "id": "R-HSA-3928584", "name": "p-EPHs bind SRC,FYN,YES,LYN", "equation": "", "summary": "Src family kinases (SFKs) are one of the important components of EPH receptor-mediated axon guidance. Inhibition of SFK-mediated phosphorylation in retinal axons, abolishes EPHA-mediated repulsion in stripe and growth cone collapse assays (Knoll & Drescher 2004). Several members of the Src family, including SRC, FYN, LYN and YES, are expressed widely in the same places as EPH receptors. Autophosphorylated tyrosines in the juxtamembrane region of the EPH receptors have been shown to be critical for the association of the SRC and FYN SH2 domain (Ellis et al. 1996, Zisch et al. 1998). These SFKs are involved in the phosphorylation of RhoGEF ephexin1 and cortactin (Knoll & Drescher 2004). This event is deduced on the basis of experimental evidence from chicken assay studies (Knoll & Drescher 2004).

Specifically, activated EPHA4 was shown to form a complex with FYN and LYN kinases (Prevost et al. 2002).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P29320-1", "P29323-1", "Q5JZY3-1", "P54764-1", "P54760-1", "P29317-1", "P29322-1", "P54753-1", "P54756-1", "P54762-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928584", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928584" } ] }, { "id": "R-HSA-3928602", "name": "NGEF binds EPHA", "equation": "", "summary": "Ephexin1/NGEF (Neuronal guanine nucleotide exchange factor) is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, which interacts with cytoplasmic domain of EPHAs. NGEF is highly expressed in the CNS during development and is enriched in neuronal growth cones. NGEF binds to the kinase domain of EPHA through its Dbl homology (DH)-pleckstrin-homology (PH) domains and this binding does not require activation of the receptor. EPHA activation by ephrinA ligands increases the catalytic activity of ephexin1 resulting in enhanced RHOA activation in cortical neurons (Noren & Pasquale 2004, Shamah et al. 2001). Ephrin-A1 also induces the dispersal of acetylcholine receptors clusters at the neuromuscular junction through the activation of NGEF and RhoA (Shi et al., 2010). NGEF is involved in both axonal growth,growth cone collapse, dendritic spine elimination and stabilization of the neuromuscular junction. In the absence of ephrin stimulation, NGEF promotes actin polymerization and axonal growth by stimulating RHOA, RAC1 and CDC42. Whereas in the presence of ephrin stimulation, NGEF induces growth cone collapse by activating RHOA, but not RAC1 and CDC42 (Shamah et al. 2001, Sahin et al. 2005).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P29320-1", "Q5JZY3-1", "P54764-1", "P29317-1", "P29322-1", "P54756-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928602", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928602" } ] }, { "id": "R-HSA-3928604", "name": "SFKs phosphorylate VAV2,3", "equation": "", "summary": "Upon ephrin (EFN)-mediated stimulation, proto-oncogene vav (VAV) is transiently tyrosine phosphorylated and activated in neurons, possibly by Src family kinases (SFKs). VAV2 and VAV3 are phosphorylated on Y172 and Y173 respectively in the acidic domain and this phosphorylation disrupts the inhibitory interaction of the acidic domain with the DH domain (Cowan et al. 2005, Marignani & Carpenter 2001).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P29320-1", "P29323-1", "Q5JZY3-1", "P54764-1", "P54760-1", "P29317-1", "P29322-1", "P54753-1", "P54756-1", "P54762-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928604" } ] }, { "id": "R-HSA-3928607", "name": "p-EPHs bind VAV2,3", "equation": "", "summary": "The alternate method required for the initial EPH receptor:ephrin (EPH:EFN) adhesion into repulsion is by RAC-dependent endocytosis, an atypical endocytic mechanism by which the EPH:EFN complex and surrounding plasma membrane are internalized into one cell. Proto-oncogene vavs (VAVs) provide a molecular link between activated EPHs and RAC-dependent endocytosis. Upon the activation of EPH receptor, VAV proteins are recruited to the intracellular domain of EPHs and become transiently activated. Cowan et al. showed that VAV2 interacts with either EPHA4 or EPHB2, indicating that VAV can bind to either EPHA or EPHB subclass receptors. Autophosphorylated juxta-membrane tyrosines (Y596 and Y602 of human EPHA4) provide docking sites for VAV proteins (Cowan et al. 2007).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P29320-1", "P29323-1", "Q5JZY3-1", "P54764-1", "P54760-1", "P29317-1", "P29322-1", "P54753-1", "P54756-1", "P54762-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928607", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928607" } ] }, { "id": "R-HSA-3928623", "name": "EPHBs bind NMDARs", "equation": "", "summary": "EPHBs are involved in spine synapse formation and also for the recruitment and clustering of glutamate receptors to synapses. At the time of synaptogenesis, EPHBs are localized to the postsynaptic region of excitatory synapses. These postsynaptic EPHBs, upon activation by presynaptic ephrinBs (EFNBs), directly interact with ionotropic glutamate receptor, NR1 and NR2B (NMDAR1and 2B aka GRIN1and 2B). The interaction between EPHB and NMDARs is mediated by the extracellular domains of these two proteins. This interaction promotes clustering of NMDARs at synaptic locations and leads to the formation of functional presynaptic release sites. Activated EPHBs function as tyrosine kinases and may also indirectly potentiate NMDAR-mediated calcium influx (Dalva et al. 2000, Takasu et al. 2002).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P29323-1", "P54760-1", "P54753-1", "P54762-1" ], "evidence": [ { "id": "R-HSA-3928623", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928623" } ] }, { "id": "R-HSA-3928627", "name": "EPHB phosphorylates TIAM1", "equation": "", "summary": "Once recruited to the EPHB:NMDAR complex, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is phosphorylated on tyrosine 829 by either EPHB or a kinase that associates with activated EPHB. TIAM1 may then activate Rac1, leading to actin cytoskeletal remodelling required for spine development and morphogenesis (Tolias et al. 2007).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P29323-1", "P54760-1", "P54753-1", "P54762-1" ], "evidence": [ { "id": "R-HSA-3928627", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928627" } ] }, { "id": "R-HSA-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "equation": "", "summary": "Activated proto-oncogene vav (VAV) act as guanine nucleotide exchange factors (GEFs) for RAC1, catalysing the exchange of bound GDP for GTP. Endocytosis of large EPH:EFN complexes is dependent on RAC1-regulated actin polymerization. RAC1 signaling is positively linked to EPH:EFN internalization but the exact link to clathrin endocytosis machinery remains unclear. Inhibiting RAC1 signalling and Arp2/3-driven actin polymerization in EPH receptor-expressing cells completely blocks both endocytosis of EPH:EFN complexes and cell retraction (Marston et al. 2003). In response to repulsive guidance molecules, the function of RAC1 changes from promoting actin polymerization associated with axon growth to driving endocytosis of the plasma membrane, resulting in growth cone collapse (Jurney et al. 2002).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P63000-1", "P07947-1", "P07948-1", "P29320-1", "P29323-1", "Q5JZY3-1", "P54764-1", "P54760-1", "P29317-1", "P29322-1", "P54753-1", "P54756-1", "P54762-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928628", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928628" } ] }, { "id": "R-HSA-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "equation": "", "summary": "Activation of EPH receptors triggers the local activation of T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) and this in turn activates RAC1 (Yoo et al. 2010). RAC1 signaling is positively linked to EPH:ephrin (EFN) internalization but the exact link to clathrin endocytosis machinery remains unclear. TIAM1 co-localizes with the ARP2/3 complex at sites of actin polymerization. RAC1 activated by TIAM1 then subsequently activates the ARP2/3 complex proteins leading to actin polymerization (Ten Klooster et al. 2006).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P63000-1", "P07947-1", "P07948-1", "P29320-1", "Q5JZY3-1", "P54764-1", "P29317-1", "P29322-1", "P54756-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928642", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928642" } ] }, { "id": "R-HSA-3928645", "name": "EPHB:NMDAR binds TIAM1", "equation": "", "summary": "T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a Rac1-specific GEF, highly expressed in the nervous system, which is necessary for proper spinal and synapse development. It is one of the critical mediators of NMDA receptor (NMDAR)-dependent spine development (Tolias et al. 2005). TIAM1 might also play a role in regulating EPHB-dependent spine morphogenesis. TIAM1 appears to be required for ephrinB (EFNB)-induced increase in spine density. TIAM1 is recruited to EPHB complexes containing NMDAR after EPHB receptor activation in neurons. The PH-CC-Ex (consisting of a pleckstrin homology (PH) domain followed by a coiled-coiled (CC) domain and an adjacent region (Ex) domain) of TIAM1 is required for binding to EPHB2 (Tolias et al. 2007).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P29323-1", "P54760-1", "P54753-1", "P54762-1" ], "evidence": [ { "id": "R-HSA-3928645", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928645" } ] }, { "id": "R-HSA-3928648", "name": "SFKs phosphorylate NGEF", "equation": "", "summary": "Activation of EPHAs leads to phosphorylation of ephexin1 (NGEF) on conserved tyrosine (Y) 179 (Y87 in isoform3) by Src family kinases (SFKs). This phosphorylation preferentially activates NGEF\u2019s GDP/GTP exchange activity specifically towards RHOA but not RAC1 and CDC42, thus switching the substrate preference of NGEF and leading to actin cytoskeletal changes that result in growth cone collapse (Sahin et al. 2005, Knoll and Drescher 2004).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P29320-1", "Q5JZY3-1", "P54764-1", "P29317-1", "P29322-1", "P54756-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928648" } ] }, { "id": "R-HSA-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "equation": "", "summary": "The tyrosine phosphorylation of ephexin1 (NGEF)/Ephexin-1 enhances its exchange activity and specifically activates inactive RHOA:GDP to active RHOA:GTP. Activated RHOA regulates myosin II activity in neurons through Rho-associated kinase (ROCK), and leads to rapid growth cone collapse, neurite retraction, or neurite growth inhibition in axons. Through this repulsive mechanism EPH receptors and ephrins (EFNs) guide retinal axons to their targets in the visual centres in the brain (Sahin et al. 2005).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P61586-1", "P29320-1", "Q5JZY3-1", "P54764-1", "P29317-1", "P29322-1", "P54756-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-3928651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928651" } ] }, { "id": "R-HSA-4093327", "name": "EPHA binds TIAM1", "equation": "", "summary": "T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a GEF exhibiting highest specificity for RAC1 and is critically involved in EPH/ephrin (EFN)-mediated neurite outgrowth and dendritic spine development (Tanaka et al. 2004, Tolias et al. 2007). TIAM1 has a role in regulating the endocytosis of EPHA receptors, by regulating the RAC1 signaling downstream of the EPHA8 receptor. Yoo and his colleagues found that TIAM1, a RAC-specific guanine nucleotide exchange factor, co-immunoprecipitates with EPHA8 in response to EFNA5 stimulation. TIAM1 associates with EPHA8 in the juxtamembrane (JM) region. Deletion of the JM region or down-regulation of TIAM1 expression compromises EPHA8:EFNA5 endocytosis (Yoo et al. 2010).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21709-1", "P06241-1", "P07947-1", "P07948-1", "P29320-1", "Q5JZY3-1", "P54764-1", "P29317-1", "P29322-1", "P54756-1", "Q15375-1", "Q9UF33-1" ], "evidence": [ { "id": "R-HSA-4093327", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4093327" } ] }, { "id": "R-HSA-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "equation": "", "summary": "Phosphorylated T-lymphoma invasion and metastasis-inducing protein 1 (p-TIAM1) bound to EPHB complexes containing NMDARs, promotes spine morphogenesis by activating RAC1, which triggers actin cytoskeletal remodelling that is essential for spine development (Tolias et al. 2007, Tolias et al. 2005).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P63000-1", "P07947-1", "P07948-1", "P29323-1", "P54760-1", "P54753-1", "P54762-1" ], "evidence": [ { "id": "R-HSA-4093336", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4093336" } ] }, { "id": "R-HSA-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "equation": "", "summary": "Cbl is constitutively associated with Grb2 in resting hematopoietic cells (Anderson et al. 1997, Odai et al. 1995, Park et al. 1998, Panchamoorthy et al. 1996). Both the SH2 and SH3 domains of Grb2 are involved. Cbl has 2 distinct C-terminal domains, proximal and distal. The proximal domain binds Grb2 in resting and stimulated cells, and in stimulated cells also binds Shc. The distal domain can bind the adaptor protein CRKL.

; Tyrosine phosphorylation of Cbl in response to IL-3 releases the SH3 domain of Grb2 which then is free to bind other molecules (Park et al. 1998).
Cbl also associates with Fyn (Anderson et al. 1997) and the related kinases Hck and Lyn (Hunter et al. 1999). Binding studies indicate that this binding is independent of the phosphorylation state of Cbl; The association of Fyn with Cbl has been described as constitutive (Hunter et al. 1999).

; Cbl further associates with the p85 subunit of PI3K (Hartley et al. 1995, Anderson et al. 1997, Hunter et al. 1997), this is also described as constitutive and is mediated by the SH3 domain of p85 (Hunter et al. 1997).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42336-1", "P06241-1", "P22681-1", "P07947-1", "P07948-1", "P08631-1", "P43405-1", "P42338-1", "O00329-1" ], "evidence": [ { "id": "R-HSA-879917", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-879917" } ] }, { "id": "R-HSA-8937820", "name": "SRC,YES1 bind YAP1", "equation": "", "summary": "Based on studies in rat osteosarcoma cell line, activated SRC and YES1 form a complex with YAP1 (Zaidi et al. 2004).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P12931-1", "P07947-1" ], "evidence": [ { "id": "R-HSA-8937820", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8937820" } ] }, { "id": "R-HSA-8937844", "name": "SRC,YES1 phosphorylate YAP1", "equation": "", "summary": "Based on studies in rat, activated SRC and/or YES1 tyrosine kinases phosphorylate YAP1 on an unknown tyrosine residue (Zaidi et al. 2004).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-HSA-8937843" ], "enzyme_list": [ "P12931-1", "P07947-1" ], "evidence": [ { "id": "R-HSA-8937844", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8937844" } ] }, { "id": "R-HSA-912627", "name": "CBL ubiquitinates PI3K", "equation": "", "summary": "Cbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl-B targets PI3K for ubiquitination and degradation in T cells (Fang et al. 2000). Similarly, Cbl activation by tyrosine phosphorylation increases PI3K ubiquitination and proteasomal degradation (Dufour et al. 2008).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42336-1", "P06241-1", "P22681-1", "P07947-1", "P07948-1", "P08631-1", "P43405-1", "P42338-1", "O00329-1" ], "evidence": [ { "id": "R-HSA-912627", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912627" } ] }, { "id": "R-HSA-912629", "name": "CBL is tyrosine phosphorylated", "equation": "", "summary": "Cbl is tyrosine phosphorylated following stimulation with IL-3 (Anderson et al. 1997) and GM-CSF (Odai et al. 1995). Cbl may be phosphorylated prior to this IL-3 stimulated tyrosyl phosphorylation (Park et al. 1998). The kinase responsible for Cbl phosphorylation may be dependent on cell type; Fyn is demonstrated to have the ability to phosphorylate Cbl (Hunter et al. 1999), other candidates include Hck, Lyn (Hunter et al. 1999) and Syk (Park et al. 1998).

; Tyrosines 700, 731 and 774 are the major sites of Cbl phosphorylation by non-receptor protein tyrosine kinases, with none showing any particular specificity for sites (Tsygankov et al. 2001). Fyn was observed to be constitutively associated with Cbl in lysates of several different cell types including the interleukin-3-dependent murine myeloid cell line 32Dcl3, and the prolactin-dependent rat thymoma cell line Nb2. Cbl phosphorylation at Y731 is postulated to provide an additional interaction between Cbl and the SH2 domain of p85-PI3K (Hunter et al. 1999). Cbl-p85 association increases in activated cells (Panchamoorthy et al. 1996). Expression of a Cbl Y731F mutant which abolishes binding of Cbl to p85 markedly increased levels of p85-PI3K (Dufour et al. 2008). Cbl-p85 binding negatively regulates PI3K activity (Fang et al. 2001); Cbl phosphorylation increased PI3K ubiquitination and proteasome degradation (Dufour et al. 2008). Cbl association with members of the Crk family is mediated by phosphorylation of Y700 and Y774 (Andoniou et al. 1996), binding with Vav is mediated by Y770 (Marengere et al 1997).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42336-1", "P06241-1", "P22681-1", "P07947-1", "P07948-1", "P08631-1", "P43405-1", "P42338-1", "O00329-1" ], "evidence": [ { "id": "R-HSA-912629", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912629" } ] }, { "id": "R-HSA-9664261", "name": "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK", "equation": "", "summary": "Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P09769-1", "P08631-1", "P43405-1" ], "evidence": [ { "id": "R-HSA-9664261", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664261" } ] }, { "id": "R-HSA-9664275", "name": "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers", "equation": "", "summary": "After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07947-1", "P07948-1", "P09769-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9664275", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664275" } ] }, { "id": "R-HSA-9670412", "name": "Phosphorylation of STATs downstream of KIT mutants", "equation": "", "summary": "Extracellular- , juxtamembrane- and kinase-domain mutants of KIT have been shown to activate the STAT pathway, as assessed by STAT phosphorylation. The biological relevance of each STAT isoform varies between tumor types (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hara et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004; reviewed in Lennartsson and Roonstrand, 2012).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670412", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670412" } ] }, { "id": "R-HSA-9670413", "name": "JAK2 binds to p-KIT mutants", "equation": "", "summary": "Activation of STAT signaling has been observed downstream of a number of oncogenic KIT mutants, both juxtamembrane and kinase domain mutants, although the biological relevance or each STAT isoform varies between tumor types (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hana et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004). Although the pathway details haven't been examined in all cases, this likely occurs through the recruitment of JAK2 and SRC family kinases, as is the case for the wild type receptor (reviewed in Lennartsson and Roonstrand, 2012).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670413", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670413" } ] }, { "id": "R-HSA-9670414", "name": "KIT mutants bind SFKs", "equation": "", "summary": "Signaling downstream of KIT mutants occurs in part through SRC family kinases, as is the case for the wild-type receptor (Paronetto et al, 2004; Krystal et al, 1998; Schittenhelm et al, 2006; Tatton et al, 2003; Timokhina et al, 1998; reviewed in Lanneartsson and Roonstrand, 2012). The dependence of different KIT mutants on SRC family signaling varies, however, with mutants such as the common D816V showing less requirement for SFK-mediated signaling (Sun et al, 2009).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670414", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670414" } ] }, { "id": "R-HSA-9670416", "name": "Recruitment of STATs by KIT mutants", "equation": "", "summary": "Extracellular- , juxtamembrane- and kinase-domain mutants of KIT have been shown to signal through the STAT pathway, although the biological relevance or each STAT isoform varies between tumor types (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hara et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004). Although the pathway details haven't been examined in all cases, STAT pathway activation likely occurs through the recruitment of JAK2 and SRC family kinases, as is the case for the wild type receptor (reviewed in Lennartsson and Roonstrand, 2012).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670416", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670416" } ] }, { "id": "R-HSA-9670417", "name": "Dimerization of STATs downstream of KIT mutants", "equation": "", "summary": "Activation of STAT signaling suggests that STATs dimerize downstream of activating KIT mutations as is the case with the wild-type receptor, although this hasn't been directly demonstrated in all cases (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hara et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004; reviewed in Lennartsson and Roonstrand, 2012).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670417", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670417" } ] }, { "id": "R-HSA-9670418", "name": "Phosphorylation of JAK2 downstream of KIT mutants", "equation": "", "summary": "Although the details haven't been examined in detail in all cases, phosphorylation of JAK2 likely occurs downstream of oncogenic mutations of KIT, as is the case for the wild-type receptor (Brizzi et al, 1999; Ning et al, 2001; Hirota et al, 1998; reviewed in Lennartsson and Roonstrand, 2012).; ;", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670418", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670418" } ] }, { "id": "R-HSA-9670426", "name": "Disassociation and translocation of STATs to the nucleus downstream of KIT mutants", "equation": "", "summary": "STATs are assumed to dissociate from the receptor and translocate to the nucleus downstream of activated KIT receptors to propagate STAT-dependent signaling (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hara et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004; reviewed in Lennartsson and Roonstrand, 2012).", "cellular_location": "cytosol, nucleoplasm, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60674-1", "P06241-1", "P10721-1", "P06239-1", "P07947-1", "P07948-1" ], "evidence": [ { "id": "R-HSA-9670426", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670426" } ] }, { "id": "R-HSA-9680348", "name": "PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated", "equation": "", "summary": "The PIK3R1 (p85alpha) subunit of phosphatidylinositol 3-kinase (PI3K) is phosphorylated and binds CBL and CSF1R (inferred from mouse homologs). CBL also directly binds phosphorylated CSF1R (inferred from mouse homologs). GRB2:SOS1 transiently interacts with CSF1R (inferred from mouse homologs) and PI3K (Saleem et al. 1995) in response to CSF1. SHC1 (SHC) interacts with CBL and CSF1R (inferred from mouse homologs). CBL is constitutively bound to GRB2, CBL is phosphorylated, and phosphorylated CBL binds phosphorylated SHC (inferred from mouse homologs). PLCG2 (PLC-gamma2), expressed in the myeloid lineage, binds phosphorylated tyrosine-723 of CSF1R and PLCG2 is phosphorylated in a process that requires the activity of PI3K (inferred from mouse homologs). GRAP2 (MONA) binds phosphorylated tyrosine-699 of CSF1R. GRB2 also interacts with CSF1R (Kharbanda et al. 1995) via phosphotyrosine-699 ( inferred from mouse homologs). GRAP2 binds GAB3, which is then phosphorylated (inferred from mouse homologs). In response to CSF1, the scaffolding protein GAB2 associates with INPP5D (SHIP1) and other proteins involved in CSF1 signaling and GAB2 is phosphorylated directly or indirectly by CSF1R (inferred from mouse homologs). INPPD5D also interacts with the kinase LYN (Baran et al. 2003). INPPL1 (SHIP2), a homolog of INPPD5, binds CSF1R in response to CSF1 (inferred from mouse homologs). GAB3, a homolog of GAB2, associates with CSF1R, is phosphorylated, and interacts with PI3K and PTPN11 (SHP2) (inferred from mouse homologs). The SRC family kinases SRC, FYN, and YES1 (YES) bind phosphorylated CSF1R (Courtneidge et al. 1993, Li et al. 1997, also inferred from mouse homologs). STAT proteins STAT1 and STAT3 bind CSF1R and are phosphorylated (inferred from mouse homologs). STAT5 also appears to be phosphorylated in response to CSF1 (Knowlton et al. 2010). THOC5 (FMIP) binds CSF1R and is phosphorylated (inferred from mouse homologs). The order of binding and phosphorylation of the interactors of CSF1R is unknown. Different subpopulations of CSF1R may be bound to different sets of interactors (inferred from mouse homologs).", "cellular_location": "plasma membrane", "input_participant_list": [ "R-HSA-197940", "R-HSA-202367", "R-HSA-354251", "R-HSA-200917", "R-HSA-9628701", "R-HSA-373640", "R-HSA-913354", "R-HSA-9682751" ], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P42336-1", "P48736-1", "P06241-1", "P12931-1", "P22681-1", "O15357-1", "P07947-1", "P07948-1", "P16885-1", "Q06124-2", "P08631-1", "P42338-1", "Q92835-1" ], "evidence": [ { "id": "R-HSA-9680348", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680348" } ] }, { "id": "R-HSA-9680385", "name": "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS", "equation": "", "summary": "SOS1 (SOS) is stably bound to GRB2, which transiently associates with phosphorylated CSF1R. In response to the activation of CSF1R by CSF1, SOS1 promotes RAS to exchange of GDP for GTP (inferred from mouse homologs) and thereby activates the RAS-RAF-MEK-ERK1,2 signaling pathway. Myeloid cells contain the KRAS isoform of RAS. KRAS:GTP enhances proliferation of macrophages (inferred from mouse homologs).
GRB2 has been shown to bind phosphotyrosine-699 of CSF1R (phosphotyrosine-697 of mouse Csf1r), however phosphorylation of tyrosines 544, 559, and 807 of mouse Csf1r are together sufficient for the full proliferative response mediated via the RS-RAF-MEK-ERK1,2 pathway (Yu et al. 2012) and mouse Csf1r lacking phosophotyrosine-697 can still activate ERK (Lee and States 2000), Csf1r phosphotyrosine-697 (human CSF1R phosphotyrosine-699) is likely not the only GRB2:SOS binding site", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P07947-1", "P08631-1", "P01116-1" ], "evidence": [ { "id": "R-HSA-9680385", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680385" } ] }, { "id": "R-HSA-9680388", "name": "CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine", "equation": "", "summary": "In response to CSF1, PLCG2 (phospholipase C gamma2) associates with CSF1R, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Imamura et al. 1990, Nakamura et al. 1992, Obba et al. 2015, also inferred from mouse homologs). PLCG2 activates pathways that enhance differentiation of macrophages (inferred from mouse homologs).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P42336-1", "P48736-1", "P06241-1", "P12931-1", "P22681-1", "O15357-1", "P07947-1", "P07948-1", "P16885-1", "Q06124-2", "P08631-1", "P42338-1", "Q92835-1" ], "evidence": [ { "id": "R-HSA-9680388", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680388" } ] }, { "id": "R-HSA-9680389", "name": "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2", "equation": "", "summary": "Phosphatidylinositol 3-kinase (PI3K) associated with the activated receptor for CSF1, CSF1R (M-CSFR), phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) to yield phosphatidylinositol 3,4,5-trisphosphate (PIP3) (Saleem et al. 1995, also inferred from mouse homologs). The regulatory subunit of PI3K, PIK3R1 (p85alpha), binds phosphotyrosine-723 (721 in the mouse homologs) of CSF1R (inferred from mouse homologs). PI3K is important for proliferation, migration, and anti-inflammatory activity of macrophages (inferred from mouse homologs).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P42336-1", "P48736-1", "P06241-1", "P12931-1", "P22681-1", "O15357-1", "P07947-1", "P07948-1", "P16885-1", "Q06124-2", "P08631-1", "P42338-1", "Q92835-1" ], "evidence": [ { "id": "R-HSA-9680389", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680389" } ] }, { "id": "R-HSA-9733316", "name": "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL", "equation": "", "summary": "After CBL is phosphorylated and binds CSF1R, CBL autopolyubiquitinates and polyubiquitinates CSF1R (inferred from mouse homologs). The ubiquitination of CSF1R results in a subsequent wave of phosphorylation by CSF1R and the internalization and proteolysis of CSF1R (inferred from mouse homologs). Thus multiubiquitination of CSF1R is required for full activity of CSF1R and for termination of signaling by CSF1R.", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P22681-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9733316", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733316" } ] }, { "id": "R-HSA-9733323", "name": "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL", "equation": "", "summary": "CBL binds the phosphorylated CSF1R and is phosphorylated (inferred from mouse homologs). CBL is observed to bind phosphotyrosine-969 but mutation of tyrosine-561 has a greater effect on phosphoryation of CBL and multiubiquitination of CSF1R by CBL (inferred from mouse homologs). Based on response to inhibitors, the phosphorylation of CBL is catalyzed by SRC family kinases (inferred from mouse homologs).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P22681-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9733323", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733323" } ] }, { "id": "R-HSA-9733330", "name": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1", "equation": "", "summary": "After an initial wave of phosphorylation of CSF1R, the stable GRB2:SOS1 complex transiently binds phospho-CSF1R (inferred from mouse homologs). GRB2 has been shown to bind phosphotyrosine-699, though another phosphotyrosine residue may be involved in transient binding of GRB2 (inferred from mouse homologs).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9733330", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733330" } ] }, { "id": "R-HSA-9733331", "name": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1", "equation": "", "summary": "GRB2:SOS1 transiently associates with phosphorylated CSF1R after CSF1R undergoes an initial wave of autophosphorylation (Wang et al. 1999). GRB2:SOS1 then dissociates from CSF1R.", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9733331", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9733331" } ] }, { "id": "R-HSA-9817983", "name": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL", "equation": "", "summary": "The ubiquitin E3 ligase CBL associates with the phosphorylated CSF1R.", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P22681-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9817983", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9817983" } ] }, { "id": "R-HSA-9818010", "name": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1", "equation": "", "summary": "After phosphorylation of CSF-1R tyrosine-Y561, SFKs bind the phosphotyrosine-561 site (inferred from mouse homologs).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07333-1", "P06241-1", "P12931-1", "P07947-1", "P08631-1" ], "evidence": [ { "id": "R-HSA-9818010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9818010" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-195066", "participant_name": "VAV1 [cytosol]", "crossref": [ { "id": "P15498", "database": "UniProt", "url": "" }, { "id": "6NF1", "database": "PDB", "url": "" }, { "id": "P15498", "database": "Pharos - Targets", "url": "" }, { "id": "6NFA", "database": "PDB", "url": "" }, { "id": "ENSG00000141968", "database": "OpenTargets", "url": "" }, { "id": "P15498", "database": "PRO", "url": "" }, { "id": "P15498", "database": "ZINC target", "url": "" }, { "id": "HMDBP10969", "database": "HMDB Protein", "url": "" }, { "id": "VAV_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "3BJI", "database": "PDB", "url": "" }, { "id": "NP_001245136.1", "database": "RefSeq", "url": "" }, { "id": "NP_005419.2", "database": "RefSeq", "url": "" }, { "id": "3KY9", "database": "PDB", "url": "" }, { "id": "6NEW", "database": "PDB", "url": "" }, { "id": "2CRH", "database": "PDB", "url": "" }, { "id": "2LCT", "database": "PDB", "url": "" }, { "id": "2MC1", "database": "PDB", "url": "" }, { "id": "2ROR", "database": "PDB", "url": "" }, { "id": "P15498", "database": "GeneCards", "url": "" }, { "id": "VAV_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "ENSP00000469450", "database": "Ensembl", "url": "" }, { "id": "ENSG00000141968", "database": "Ensembl", "url": "" }, { "id": "ENST00000596764", "database": "Ensembl", "url": "" }, { "id": "ENSP00000472929", "database": "Ensembl", "url": "" }, { "id": "ENST00000602142", "database": "Ensembl", "url": "" }, { "id": "ENSG00000141968-VAV1", "database": "HPA", "url": "" } ] }, { "participant_id": "R-HSA-197940", "participant_name": "INPP5D [cytosol]", "crossref": [ { "id": "Q92835", "database": "UniProt", "url": "" }, { "id": "6IBD", "database": "PDB", "url": "" }, { "id": "NP_005532.2", "database": "RefSeq", "url": "" }, { "id": "NP_001017915.1", "database": "RefSeq", "url": "" }, { "id": "5RXI", "database": "PDB", "url": "" }, { "id": "5RWF", "database": "PDB", "url": "" }, { "id": "5RYL", "database": "PDB", "url": "" }, { "id": "5RYK", "database": "PDB", "url": "" }, { "id": "5RXJ", "database": "PDB", "url": "" }, { "id": "5RXH", "database": "PDB", "url": "" }, { "id": "5RWE", "database": "PDB", "url": "" }, { "id": "5RXM", "database": "PDB", "url": "" }, { "id": "5RXO", "database": "PDB", "url": "" }, { "id": "8PDG", "database": "PDB", "url": "" }, { "id": "Q92835", "database": "Pharos - Targets", "url": "" }, { "id": "6XY7", "database": "PDB", "url": "" }, { "id": "5RWG", "database": "PDB", "url": "" }, { "id": "5RXK", "database": "PDB", "url": "" }, { "id": "5RWH", "database": "PDB", "url": "" }, { "id": "5RXL", "database": "PDB", "url": "" }, { "id": "5RXQ", "database": "PDB", "url": "" }, { "id": "5RWK", "database": "PDB", "url": "" }, { "id": "5RXP", "database": "PDB", "url": "" }, { "id": "8PDH", "database": "PDB", "url": "" }, { "id": "8PDJ", "database": "PDB", "url": "" }, { "id": "ENSG00000168918-INPP5D", "database": "HPA", "url": "" }, { "id": "5RWI", "database": "PDB", "url": "" }, { "id": "5RWJ", "database": "PDB", "url": "" }, { "id": "5RWM", "database": "PDB", "url": "" }, { "id": "5RXR", "database": "PDB", "url": "" }, { "id": "5RXS", "database": "PDB", "url": "" }, { "id": "5RWL", "database": "PDB", "url": "" }, { "id": "5RX8", "database": "PDB", "url": "" }, { "id": "5RYB", "database": "PDB", "url": "" }, { "id": "5RYC", "database": "PDB", "url": "" }, { "id": "5RW5", "database": "PDB", "url": "" }, { "id": "5RW6", "database": "PDB", "url": "" }, { "id": "5RX7", "database": "PDB", "url": "" }, { "id": "5RXA", "database": "PDB", "url": "" }, { "id": "5RXC", "database": "PDB", "url": "" }, { "id": "5RXB", "database": "PDB", "url": "" }, { "id": "5RYE", "database": "PDB", "url": "" }, { "id": "5RW7", "database": "PDB", "url": "" }, { "id": "Q92835", "database": "PRO", "url": "" }, { "id": "5RYD", "database": "PDB", "url": "" }, { "id": "5RW8", "database": "PDB", "url": "" }, { "id": "5RX9", "database": "PDB", "url": "" }, { "id": "5RXE", "database": "PDB", "url": "" }, { "id": "ENSG00000168918", "database": "OpenTargets", "url": "" }, { "id": "5RYH", "database": "PDB", "url": "" }, { "id": "5RXD", "database": "PDB", "url": "" }, { "id": "5RYF", "database": "PDB", "url": "" }, { "id": "5RWA", "database": "PDB", "url": "" }, { "id": "5RW9", "database": "PDB", "url": "" }, { "id": "5RWB", "database": "PDB", "url": "" }, { "id": "5RYG", "database": "PDB", "url": "" }, { "id": "5RYJ", "database": "PDB", "url": "" }, { "id": "5RXG", "database": "PDB", "url": "" }, { "id": "5RWD", "database": "PDB", "url": "" }, { "id": "5RYI", "database": "PDB", "url": "" }, { "id": "5RXF", "database": "PDB", "url": "" }, { "id": "5RWC", "database": "PDB", "url": "" }, { "id": "1455", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "5RY3", "database": "PDB", "url": "" }, { "id": "5RWY", "database": "PDB", "url": "" }, { "id": "5RY1", "database": "PDB", "url": "" }, { "id": "5RWW", "database": "PDB", "url": "" }, { "id": "5RY2", "database": "PDB", "url": "" }, { "id": "5RWX", "database": "PDB", "url": "" }, { "id": "5RY5", "database": "PDB", "url": "" }, { "id": "5RX1", "database": "PDB", "url": "" }, { "id": "HMDBP03787", "database": "HMDB Protein", "url": "" }, { "id": "5RY6", "database": "PDB", "url": "" }, { "id": "5RX0", "database": "PDB", "url": "" }, { "id": "3.1.3.86", "database": "IntEnz", "url": "" }, { "id": "5RY4", "database": "PDB", "url": "" }, { "id": "5RWZ", "database": "PDB", "url": "" }, { "id": "5RY8", "database": "PDB", "url": "" }, { "id": "5RX3", "database": "PDB", "url": "" }, { "id": "5RW2", "database": "PDB", "url": "" }, { "id": "5RY7", "database": "PDB", "url": "" }, { "id": "5RX2", "database": "PDB", "url": "" }, { "id": "2YSX", "database": "PDB", "url": "" }, { "id": "5RYA", "database": "PDB", "url": "" }, { "id": "5RWU", "database": "PDB", "url": "" }, { "id": "5RXZ", "database": "PDB", "url": "" }, { "id": "5RWV", "database": "PDB", "url": "" }, { "id": "5RY0", "database": "PDB", "url": "" }, { "id": "5RWS", "database": "PDB", "url": "" }, { "id": "5RXY", "database": "PDB", "url": "" }, { "id": "5RXX", "database": "PDB", "url": "" }, { "id": "5RWT", "database": "PDB", "url": "" }, { "id": "5RXV", "database": "PDB", "url": "" }, { "id": "5RWQ", "database": "PDB", "url": "" }, { "id": "5RXW", "database": "PDB", "url": "" }, { "id": "5RWR", "database": "PDB", "url": "" }, { "id": "ENST00000445964", "database": "Ensembl", "url": "" }, { "id": "ENSG00000168918", "database": "Ensembl", "url": "" }, { "id": "ENST00000629761", "database": "Ensembl", "url": "" }, { "id": "5RWN", "database": "PDB", "url": "" }, { "id": "ENSP00000405338", "database": "Ensembl", "url": "" }, { "id": "ENST00000630854", "database": "Ensembl", "url": "" }, { "id": "ENSP00000486669", "database": "Ensembl", "url": "" }, { "id": "ENSP00000487191", "database": "Ensembl", "url": "" }, { "id": "Q92835", "database": "GeneCards", "url": "" }, { "id": "5RXU", "database": "PDB", "url": "" }, { "id": "5RXT", "database": "PDB", "url": "" }, { "id": "5RWP", "database": "PDB", "url": "" }, { "id": "ENSP00000352575", "database": "Ensembl", "url": "" }, { "id": "ENSG00000281614", "database": "Ensembl", "url": "" }, { "id": "5RWO", "database": "PDB", "url": "" }, { "id": "ENST00000359570", "database": "Ensembl", "url": "" }, { "id": "5RX4", "database": "PDB", "url": "" }, { "id": "5RW3", "database": "PDB", "url": "" }, { "id": "5RX5", "database": "PDB", "url": "" }, { "id": "5RY9", "database": "PDB", "url": "" }, { "id": "5RW4", "database": "PDB", "url": "" }, { "id": "5RX6", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-200917", "participant_name": "FYN [cytosol]", "crossref": [ { "id": "P06241", "database": "UniProt", "url": "" }, { "id": "P06241", "database": "PRO", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "3H0H", "database": "PDB", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - Investigational", "url": "" }, { "id": "2026", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "7A2N", "database": "PDB", "url": "" }, { "id": "1AOT", "database": "PDB", "url": "" }, { "id": "1A0N", "database": "PDB", "url": "" }, { "id": "XP_016866139.1", "database": "RefSeq", "url": "" }, { "id": "3H0F", "database": "PDB", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - FDA approved", "url": "" }, { "id": "7A2M", "database": "PDB", "url": "" }, { "id": "7A2P", "database": "PDB", "url": "" }, { "id": "XP_016866141.1", "database": "RefSeq", "url": "" }, { "id": "3UA6", "database": "PDB", "url": "" }, { "id": "1AVZ", "database": "PDB", "url": "" }, { "id": "7A2O", "database": "PDB", "url": "" }, { "id": "3H0I", "database": "PDB", "url": "" }, { "id": "1AOU", "database": "PDB", "url": "" }, { "id": "XP_016866140.1", "database": "RefSeq", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "7A2R", "database": "PDB", "url": "" }, { "id": "1FYN", "database": "PDB", "url": "" }, { "id": "4D8D", "database": "PDB", "url": "" }, { "id": "1EFN", "database": "PDB", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - Metabolites", "url": "" }, { "id": "XP_016866142.1", "database": "RefSeq", "url": "" }, { "id": "7A2Q", "database": "PDB", "url": "" }, { "id": "3UA7", "database": "PDB", "url": "" }, { "id": "1AZG", "database": "PDB", "url": "" }, { "id": "7A2T", "database": "PDB", "url": "" }, { "id": "1M27", "database": "PDB", "url": "" }, { "id": "4U17", "database": "PDB", "url": "" }, { "id": "7A2S", "database": "PDB", "url": "" }, { "id": "1G83", "database": "PDB", "url": "" }, { "id": "XP_016866143.1", "database": "RefSeq", "url": "" }, { "id": "4EIK", "database": "PDB", "url": "" }, { "id": "ENSP00000357667", "database": "Ensembl", "url": "" }, { "id": "1NYG", "database": "PDB", "url": "" }, { "id": "ENST00000368667", "database": "Ensembl", "url": "" }, { "id": "NP_694592.1", "database": "RefSeq", "url": "" }, { "id": "P06241", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000010810", "database": "Ensembl", "url": "" }, { "id": "7A2V", "database": "PDB", "url": "" }, { "id": "ENSP00000357656", "database": "Ensembl", "url": "" }, { "id": "ENSP00000229471", "database": "Ensembl", "url": "" }, { "id": "ENST00000368678", "database": "Ensembl", "url": "" }, { "id": "4ZNX", "database": "PDB", "url": "" }, { "id": "ENST00000354650", "database": "Ensembl", "url": "" }, { "id": "1NYF", "database": "PDB", "url": "" }, { "id": "7A2U", "database": "PDB", "url": "" }, { "id": "ENSP00000357671", "database": "Ensembl", "url": "" }, { "id": "ENSP00000346671", "database": "Ensembl", "url": "" }, { "id": "ENST00000229471", "database": "Ensembl", "url": "" }, { "id": "4U1P", "database": "PDB", "url": "" }, { "id": "NP_002028.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000010810", "database": "OpenTargets", "url": "" }, { "id": "7A2K", "database": "PDB", "url": "" }, { "id": "7A2Z", "database": "PDB", "url": "" }, { "id": "2MRJ", "database": "PDB", "url": "" }, { "id": "2MRK", "database": "PDB", "url": "" }, { "id": "XP_005266949.1", "database": "RefSeq", "url": "" }, { "id": "7A2L", "database": "PDB", "url": "" }, { "id": "2DQ7", "database": "PDB", "url": "" }, { "id": "6IPY", "database": "PDB", "url": "" }, { "id": "7A2X", "database": "PDB", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "6IPZ", "database": "PDB", "url": "" }, { "id": "7A2J", "database": "PDB", "url": "" }, { "id": "XP_005266947.1", "database": "RefSeq", "url": "" }, { "id": "7A2Y", "database": "PDB", "url": "" }, { "id": "2MQI", "database": "PDB", "url": "" }, { "id": "P06241", "database": "ZINC target", "url": "" }, { "id": "1SHF", "database": "PDB", "url": "" }, { "id": "5ZAU", "database": "PDB", "url": "" }, { "id": "P06241", "database": "GeneCards", "url": "" }, { "id": "ENSG00000010810-FYN", "database": "HPA", "url": "" }, { "id": "FYN_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "1ZBJ", "database": "PDB", "url": "" }, { "id": "6EDF", "database": "PDB", "url": "" }, { "id": "7A2W", "database": "PDB", "url": "" }, { "id": "NP_694593.1", "database": "RefSeq", "url": "" }, { "id": "ENST00000368682", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-HSA-202367", "participant_name": "GRAP2 [cytosol]", "crossref": [ { "id": "O75791", "database": "UniProt", "url": "" }, { "id": "NP_004801.1", "database": "RefSeq", "url": "" }, { "id": "5GJH", "database": "PDB", "url": "" }, { "id": "ENSG00000100351", "database": "Ensembl", "url": "" }, { "id": "ENSG00000100351", "database": "OpenTargets", "url": "" }, { "id": "ENST00000344138", "database": "Ensembl", "url": "" }, { "id": "ENSP00000385607", "database": "Ensembl", "url": "" }, { "id": "O75791", "database": "PRO", "url": "" }, { "id": "ENST00000407075", "database": "Ensembl", "url": "" }, { "id": "ENSP00000339186", "database": "Ensembl", "url": "" }, { "id": "O75791", "database": "GeneCards", "url": "" }, { "id": "NP_001278753.1", "database": "RefSeq", "url": "" }, { "id": "O75791", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000100351-GRAP2", "database": "HPA", "url": "" }, { "id": "NP_001278754.1", "database": "RefSeq", "url": "" }, { "id": "NP_001278757.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-HSA-354251", "participant_name": "LYN [cytosol]", "crossref": [ { "id": "P07948", "database": "UniProt", "url": "" }, { "id": "ENSP00000428424", "database": "Ensembl", "url": "" }, { "id": "XP_016868905.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000254087", "database": "Ensembl", "url": "" }, { "id": "P07948", "database": "GeneCards", "url": "" }, { "id": "ENST00000519728", "database": "Ensembl", "url": "" }, { "id": "LYN_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "LYN_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "ENST00000520220", "database": "Ensembl", "url": "" }, { "id": "ENSP00000428924", "database": "Ensembl", "url": "" }, { "id": "NP_001104567.1", "database": "RefSeq", "url": "" }, { "id": "LYN_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "NP_002341.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000254087", "database": "OpenTargets", "url": "" }, { "id": "HMDBP13811", "database": "HMDB Protein", "url": "" }, { "id": "2.7.10.2", "database": "IntEnz", "url": "" }, { "id": "LYN_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "P07948", "database": "ZINC target", "url": "" }, { "id": "2060", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "P07948", "database": "PRO", "url": "" }, { "id": "ENSG00000254087-LYN", "database": "HPA", "url": "" }, { "id": "LYN_HUMAN", "database": "ZINC - Investigational", "url": "" }, { "id": "LYN_HUMAN", "database": "ZINC - FDA approved", "url": "" }, { "id": "3A4O", "database": "PDB", "url": "" }, { "id": "1WA7", "database": "PDB", "url": "" }, { "id": "1W1F", "database": "PDB", "url": "" }, { "id": "6NMW", "database": "PDB", "url": "" }, { "id": "P07948", "database": "Pharos - Targets", "url": "" }, { "id": "5XY1", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-373640", "participant_name": "YES1 [cytosol]", "crossref": [ { "id": "P07947", "database": "UniProt", "url": "" }, { "id": "P07947", "database": "PRO", "url": "" }, { "id": "2284", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "XP_016881449.1", "database": "RefSeq", "url": "" }, { "id": "2HDA", "database": "PDB", "url": "" }, { "id": "ENSP00000462468", "database": "Ensembl", "url": "" }, { "id": "HMDBP01230", "database": "HMDB Protein", "url": "" }, { "id": "ENSG00000176105", "database": "Ensembl", "url": "" }, { "id": "ENST00000584307", "database": "Ensembl", "url": "" }, { "id": "ENSG00000176105", "database": "OpenTargets", "url": "" }, { "id": "P07947", "database": "GeneCards", "url": "" }, { "id": "ENST00000314574", "database": "Ensembl", "url": "" }, { "id": "YES_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "ENSP00000324740", "database": "Ensembl", "url": "" }, { "id": "YES_HUMAN", "database": "ZINC - Investigational", "url": "" }, { "id": "YES_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "YES_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "YES_HUMAN", "database": "ZINC - FDA approved", "url": "" }, { "id": "YES_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "NP_005424.1", "database": "RefSeq", "url": "" }, { "id": "P07947", "database": "ZINC target", "url": "" }, { "id": "P07947", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000176105-YES1", "database": "HPA", "url": "" } ] }, { "participant_id": "R-HSA-8937843", "participant_name": "p-Y-YAP1 [cytosol]", "crossref": [ { "id": "4RE1", "database": "PDB", "url": "" }, { "id": "ENSP00000431574", "database": "Ensembl", "url": "" }, { "id": "NP_001181974.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000137693", "database": "OpenTargets", "url": "" }, { "id": "6GEK", "database": "PDB", "url": "" }, { "id": "ENST00000537274", "database": "Ensembl", "url": "" }, { "id": "ENST00000615667", "database": "Ensembl", "url": "" }, { "id": "NP_001123617.1", "database": "RefSeq", "url": "" }, { "id": "8A8R", "database": "PDB", "url": "" }, { "id": "4REX", "database": "PDB", "url": "" }, { "id": "ENSP00000331023", "database": "Ensembl", "url": "" }, { "id": "6GEE", "database": "PDB", "url": "" }, { "id": "P46937", "database": "GeneCards", "url": "" }, { "id": "1K5R", "database": "PDB", "url": "" }, { "id": "ENSP00000478927", "database": "Ensembl", "url": "" }, { "id": "P46937", "database": "Pharos - Targets", "url": "" }, { "id": "6HIL", "database": "PDB", "url": "" }, { "id": "6GE6", "database": "PDB", "url": "" }, { "id": "6GE5", "database": "PDB", "url": "" }, { "id": "22672", "database": "Orphanet", "url": "" }, { "id": "ENSP00000445635", "database": "Ensembl", "url": "" }, { "id": "NP_001269027.1", "database": "RefSeq", "url": "" }, { "id": "ENST00000526343", "database": "Ensembl", "url": "" }, { "id": "ENST00000629586", "database": "Ensembl", "url": "" }, { "id": "3MHR", "database": "PDB", "url": "" }, { "id": "6G8Q", "database": "PDB", "url": "" }, { "id": "NP_001269028.1", "database": "RefSeq", "url": "" }, { "id": "6Q2X", "database": "PDB", "url": "" }, { "id": "ENSP00000487519", "database": "Ensembl", "url": "" }, { "id": "6GEG", "database": "PDB", "url": "" }, { "id": "6G8L", "database": "PDB", "url": "" }, { "id": "6GEI", "database": "PDB", "url": "" }, { "id": "ENST00000524575", "database": "Ensembl", "url": "" }, { "id": "ENST00000282441", "database": "Ensembl", "url": "" }, { "id": "2LAY", "database": "PDB", "url": "" }, { "id": "P46937", "database": "UniProt", "url": "" }, { "id": "6G8I", "database": "PDB", "url": "" }, { "id": "2LAX", "database": "PDB", "url": "" }, { "id": "ENSP00000434134", "database": "Ensembl", "url": "" }, { "id": "2LTV", "database": "PDB", "url": "" }, { "id": "ENST00000531439", "database": "Ensembl", "url": "" }, { "id": "7O07", "database": "PDB", "url": "" }, { "id": "3KYS", "database": "PDB", "url": "" }, { "id": "P46937", "database": "PRO", "url": "" }, { "id": "ENSP00000435602", "database": "Ensembl", "url": "" }, { "id": "5YDX", "database": "PDB", "url": "" }, { "id": "NP_001269030.1", "database": "RefSeq", "url": "" }, { "id": "1K9Q", "database": "PDB", "url": "" }, { "id": "6GE4", "database": "PDB", "url": "" }, { "id": "1JMQ", "database": "PDB", "url": "" }, { "id": "ENSG00000137693-YAP1", "database": "HPA", "url": "" }, { "id": "ENST00000345877", "database": "Ensembl", "url": "" }, { "id": "6HIK", "database": "PDB", "url": "" }, { "id": "8A8Q", "database": "PDB", "url": "" }, { "id": "NP_001269029.1", "database": "RefSeq", "url": "" }, { "id": "ENSP00000282441", "database": "Ensembl", "url": "" }, { "id": "2LTW", "database": "PDB", "url": "" }, { "id": "6GE3", "database": "PDB", "url": "" }, { "id": "2LAW", "database": "PDB", "url": "" }, { "id": "6G6X", "database": "PDB", "url": "" }, { "id": "6G8K", "database": "PDB", "url": "" }, { "id": "5OAQ", "database": "PDB", "url": "" }, { "id": "6GEC", "database": "PDB", "url": "" }, { "id": "5YDY", "database": "PDB", "url": "" }, { "id": "ENSG00000137693", "database": "Ensembl", "url": "" }, { "id": "NP_001181973.1", "database": "RefSeq", "url": "" }, { "id": "6G8J", "database": "PDB", "url": "" }, { "id": "NP_001269026.1", "database": "RefSeq", "url": "" }, { "id": "1K9R", "database": "PDB", "url": "" }, { "id": "6G8P", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-913354", "participant_name": "INPPL1 [cytosol]", "crossref": [ { "id": "O15357", "database": "UniProt", "url": "" }, { "id": "O15357", "database": "GeneCards", "url": "" }, { "id": "5OKO", "database": "PDB", "url": "" }, { "id": "5OKP", "database": "PDB", "url": "" }, { "id": "5OKN", "database": "PDB", "url": "" }, { "id": "O15357", "database": "Pharos - Targets", "url": "" }, { "id": "6SQU", "database": "PDB", "url": "" }, { "id": "ENSP00000444619", "database": "Ensembl", "url": "" }, { "id": "3NR8", "database": "PDB", "url": "" }, { "id": "XP_011543301.1", "database": "RefSeq", "url": "" }, { "id": "4A9C", "database": "PDB", "url": "" }, { "id": "1459", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "ENST00000538751", "database": "Ensembl", "url": "" }, { "id": "ENSG00000165458", "database": "OpenTargets", "url": "" }, { "id": "ENSG00000165458", "database": "Ensembl", "url": "" }, { "id": "5OKM", "database": "PDB", "url": "" }, { "id": "ENST00000298229", "database": "Ensembl", "url": "" }, { "id": "ENSP00000298229", "database": "Ensembl", "url": "" }, { "id": "ENSG00000165458-INPPL1", "database": "HPA", "url": "" }, { "id": "2KSO", "database": "PDB", "url": "" }, { "id": "2K4P", "database": "PDB", "url": "" }, { "id": "2MK2", "database": "PDB", "url": "" }, { "id": "NP_001558.3", "database": "RefSeq", "url": "" }, { "id": "6SRR", "database": "PDB", "url": "" }, { "id": "HMDBP03264", "database": "HMDB Protein", "url": "" }, { "id": "O15357", "database": "ZINC target", "url": "" }, { "id": "O15357", "database": "PRO", "url": "" }, { "id": "21752", "database": "Orphanet", "url": "" } ] }, { "participant_id": "R-HSA-9628701", "participant_name": "SRC [cytosol]", "crossref": [ { "id": "P12931", "database": "UniProt", "url": "" }, { "id": "2BDJ", "database": "PDB", "url": "" }, { "id": "NP_938033.1", "database": "RefSeq", "url": "" }, { "id": "4MXO", "database": "PDB", "url": "" }, { "id": "1O4C", "database": "PDB", "url": "" }, { "id": "XP_011527315.1", "database": "RefSeq", "url": "" }, { "id": "4MXX", "database": "PDB", "url": "" }, { "id": "1O4D", "database": "PDB", "url": "" }, { "id": "1O42", "database": "PDB", "url": "" }, { "id": "1O4O", "database": "PDB", "url": "" }, { "id": "1A07", "database": "PDB", "url": "" }, { "id": "1O43", "database": "PDB", "url": "" }, { "id": "P12931", "database": "ZINC target", "url": "" }, { "id": "4MXY", "database": "PDB", "url": "" }, { "id": "1O4E", "database": "PDB", "url": "" }, { "id": "1A08", "database": "PDB", "url": "" }, { "id": "XP_016883513.1", "database": "RefSeq", "url": "" }, { "id": "1O4P", "database": "PDB", "url": "" }, { "id": "2H8H", "database": "PDB", "url": "" }, { "id": "25273", "database": "Orphanet", "url": "" }, { "id": "1A09", "database": "PDB", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - FDA approved", "url": "" }, { "id": "2206", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "2SRC", "database": "PDB", "url": "" }, { "id": "XP_016883514.1", "database": "RefSeq", "url": "" }, { "id": "1O4L", "database": "PDB", "url": "" }, { "id": "1YOL", "database": "PDB", "url": "" }, { "id": "7OTE", "database": "PDB", "url": "" }, { "id": "4F5B", "database": "PDB", "url": "" }, { "id": "7T1U", "database": "PDB", "url": "" }, { "id": "1YOM", "database": "PDB", "url": "" }, { "id": "4HXJ", "database": "PDB", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - Investigational", "url": "" }, { "id": "1O4A", "database": "PDB", "url": "" }, { "id": "1HCT", "database": "PDB", "url": "" }, { "id": "4K11", "database": "PDB", "url": "" }, { "id": "1O4B", "database": "PDB", "url": "" }, { "id": "1KSW", "database": "PDB", "url": "" }, { "id": "1O4M", "database": "PDB", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - Metabolites", "url": "" }, { "id": "NP_005408.1", "database": "RefSeq", "url": "" }, { "id": "1O41", "database": "PDB", "url": "" }, { "id": "1O4N", "database": "PDB", "url": "" }, { "id": "2BDF", "database": "PDB", "url": "" }, { "id": "P12931", "database": "GeneCards", "url": "" }, { "id": "1O47", "database": "PDB", "url": "" }, { "id": "1O4I", "database": "PDB", "url": "" }, { "id": "1A1E", "database": "PDB", "url": "" }, { "id": "6E6E", "database": "PDB", "url": "" }, { "id": "1Y57", "database": "PDB", "url": "" }, { "id": "6EHJ", "database": "PDB", "url": "" }, { "id": "1YI6", "database": "PDB", "url": "" }, { "id": "P12931", "database": "PRO", "url": "" }, { "id": "4F59", "database": "PDB", "url": "" }, { "id": "1YOJ", "database": "PDB", "url": "" }, { "id": "ENSG00000197122", "database": "OpenTargets", "url": "" }, { "id": "4F5A", "database": "PDB", "url": "" }, { "id": "1O48", "database": "PDB", "url": "" }, { "id": "1O4J", "database": "PDB", "url": "" }, { "id": "1FMK", "database": "PDB", "url": "" }, { "id": "1O49", "database": "PDB", "url": "" }, { "id": "1O4K", "database": "PDB", "url": "" }, { "id": "1HCS", "database": "PDB", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "7NG7", "database": "PDB", "url": "" }, { "id": "3VRO", "database": "PDB", "url": "" }, { "id": "1A1A", "database": "PDB", "url": "" }, { "id": "1O4F", "database": "PDB", "url": "" }, { "id": "XP_016883515.1", "database": "RefSeq", "url": "" }, { "id": "1O44", "database": "PDB", "url": "" }, { "id": "P12931", "database": "Pharos - Targets", "url": "" }, { "id": "1O4Q", "database": "PDB", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "ENST00000373578", "database": "Ensembl", "url": "" }, { "id": "1O4H", "database": "PDB", "url": "" }, { "id": "ENST00000373567", "database": "Ensembl", "url": "" }, { "id": "ENSP00000508666", "database": "Ensembl", "url": "" }, { "id": "ENSP00000509325", "database": "Ensembl", "url": "" }, { "id": "ENSP00000362680", "database": "Ensembl", "url": "" }, { "id": "1O46", "database": "PDB", "url": "" }, { "id": "ENSG00000197122", "database": "Ensembl", "url": "" }, { "id": "1A1C", "database": "PDB", "url": "" }, { "id": "ENSP00000362668", "database": "Ensembl", "url": "" }, { "id": "ENSP00000362659", "database": "Ensembl", "url": "" }, { "id": "ENST00000692423", "database": "Ensembl", "url": "" }, { "id": "ENST00000692112", "database": "Ensembl", "url": "" }, { "id": "ENSP00000350941", "database": "Ensembl", "url": "" }, { "id": "ENST00000373558", "database": "Ensembl", "url": "" }, { "id": "3ZMQ", "database": "PDB", "url": "" }, { "id": "ENST00000358208", "database": "Ensembl", "url": "" }, { "id": "3ZMP", "database": "PDB", "url": "" }, { "id": "1A1B", "database": "PDB", "url": "" }, { "id": "ENSG00000197122-SRC", "database": "HPA", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "6C4S", "database": "PDB", "url": "" }, { "id": "1SHD", "database": "PDB", "url": "" }, { "id": "1O4R", "database": "PDB", "url": "" }, { "id": "6ATE", "database": "PDB", "url": "" }, { "id": "XP_016883516.1", "database": "RefSeq", "url": "" }, { "id": "1O4G", "database": "PDB", "url": "" }, { "id": "SRC_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "1O45", "database": "PDB", "url": "" }, { "id": "4MXZ", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-9682751", "participant_name": "THOC5 [cytosol]", "crossref": [ { "id": "Q13769", "database": "UniProt", "url": "" }, { "id": "ENSP00000380970", "database": "Ensembl", "url": "" }, { "id": "7ZNL", "database": "PDB", "url": "" }, { "id": "Q13769", "database": "GeneCards", "url": "" }, { "id": "ENST00000397873", "database": "Ensembl", "url": "" }, { "id": "ENSP00000380971", "database": "Ensembl", "url": "" }, { "id": "Q13769", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000100296-THOC5", "database": "HPA", "url": "" }, { "id": "ENST00000490103", "database": "Ensembl", "url": "" }, { "id": "ENSG00000100296", "database": "Ensembl", "url": "" }, { "id": "ENSP00000420306", "database": "Ensembl", "url": "" }, { "id": "NP_003669.4", "database": "RefSeq", "url": "" }, { "id": "ENSP00000380969", "database": "Ensembl", "url": "" }, { "id": "ENST00000397872", "database": "Ensembl", "url": "" }, { "id": "ENST00000397871", "database": "Ensembl", "url": "" }, { "id": "NP_001002877.1", "database": "RefSeq", "url": "" }, { "id": "7APK", "database": "PDB", "url": "" }, { "id": "Q13769", "database": "PRO", "url": "" }, { "id": "ENSG00000100296", "database": "OpenTargets", "url": "" }, { "id": "HMDBP14137", "database": "HMDB Protein", "url": "" }, { "id": "7ZNK", "database": "PDB", "url": "" }, { "id": "NP_001002878.1", "database": "RefSeq", "url": "" }, { "id": "NP_001002879.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JW59", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] } ] }, { "uniprot_ac": "A0A0G2K6M9", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] } ] }, { "uniprot_ac": "A0A0R4J8U1", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] } ] }, { "uniprot_ac": "A0A8I5ZP97", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] } ] }, { "uniprot_ac": "A0A8I5ZVE3", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] } ] }, { "uniprot_ac": "A0A8I6A5T6", "gene_name": "Mst1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] } ] }, { "uniprot_ac": "A0A8I6AM23", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] } ] }, { "uniprot_ac": "A0A8I6AWX7", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] } ] }, { "uniprot_ac": "A0A8I6GCV6", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] } ] }, { "uniprot_ac": "B1WC09", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] } ] }, { "uniprot_ac": "B2RYC7", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] } ] }, { "uniprot_ac": "B5DFD6", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] } ] }, { "uniprot_ac": "D3ZBN3", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] } ] }, { "uniprot_ac": "D3ZCD0", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] } ] }, { "uniprot_ac": "D3ZD03", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] } ] }, { "uniprot_ac": "D3ZDH4", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] } ] }, { "uniprot_ac": "D3ZDS3", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] } ] }, { "uniprot_ac": "D3ZJI4", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] } ] }, { "uniprot_ac": "D3ZZK3", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] } ] }, { "uniprot_ac": "D4A584", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] } ] }, { "uniprot_ac": "D4A7W7", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] } ] }, { "uniprot_ac": "D4ADZ5", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "E9PSY0", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] } ] }, { "uniprot_ac": "E9PT20", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] } ] }, { "uniprot_ac": "F1LM93", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] } ] }, { "uniprot_ac": "F1LRZ0", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] } ] }, { "uniprot_ac": "F1LSG7", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] } ] }, { "uniprot_ac": "F1LSN4", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] } ] }, { "uniprot_ac": "F1LVI0", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] } ] }, { "uniprot_ac": "F1LYY7", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] } ] }, { "uniprot_ac": "F1M0N1", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] } ] }, { "uniprot_ac": "F1MAJ0", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] } ] }, { "uniprot_ac": "G3V6K6", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "G3V9H8", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] } ] }, { "uniprot_ac": "M0R7E7", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] } ] }, { "uniprot_ac": "M0RDA4", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] } ] }, { "uniprot_ac": "O00329", "gene_name": "PIK3CD", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "O00329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00329" } ] } ] }, { "uniprot_ac": "O08680", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] } ] }, { "uniprot_ac": "O08775", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] } ] }, { "uniprot_ac": "O09110", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] } ] }, { "uniprot_ac": "O09127", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] } ] }, { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] } ] }, { "uniprot_ac": "O15146", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] } ] }, { "uniprot_ac": "O15357", "gene_name": "INPPL1", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "O15357", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15357" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "O15357", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15357" } ] } ] }, { "uniprot_ac": "O35346", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] } ] }, { "uniprot_ac": "O35491", "gene_name": "Clk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] } ] }, { "uniprot_ac": "O35492", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] } ] }, { "uniprot_ac": "O35493", "gene_name": "Clk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] } ] }, { "uniprot_ac": "O54804", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] } ] }, { "uniprot_ac": "O54967", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] } ] }, { "uniprot_ac": "O60674", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "O62602", "gene_name": "lic", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] } ] }, { "uniprot_ac": "O70146", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] } ] }, { "uniprot_ac": "O88697", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] } ] }, { "uniprot_ac": "P00519", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] } ] }, { "uniprot_ac": "P00520", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P00533", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] } ] }, { "uniprot_ac": "P01116", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01116" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01116" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P04626", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] } ] }, { "uniprot_ac": "P04629", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] } ] }, { "uniprot_ac": "P05480", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] } ] }, { "uniprot_ac": "P05532", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] } ] }, { "uniprot_ac": "P05622", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] } ] }, { "uniprot_ac": "P06239", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] } ] }, { "uniprot_ac": "P06240", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] } ] }, { "uniprot_ac": "P06241", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] } ] }, { "uniprot_ac": "P06494", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] } ] }, { "uniprot_ac": "P06784", "gene_name": "STE7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] } ] }, { "uniprot_ac": "P07332", "gene_name": "FES", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] } ] }, { "uniprot_ac": "P07333", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] } ] }, { "uniprot_ac": "P07947", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] } ] }, { "uniprot_ac": "P07948", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] } ] }, { "uniprot_ac": "P07949", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] } ] }, { "uniprot_ac": "P08018", "gene_name": "PBS2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] } ] }, { "uniprot_ac": "P08069", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] } ] }, { "uniprot_ac": "P08103", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] } ] }, { "uniprot_ac": "P08581", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] } ] }, { "uniprot_ac": "P08630", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] } ] }, { "uniprot_ac": "P08631", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] } ] }, { "uniprot_ac": "P08922", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] } ] }, { "uniprot_ac": "P08923", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] } ] }, { "uniprot_ac": "P09208", "gene_name": "InR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P09581", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09581" } ] } ] }, { "uniprot_ac": "P09619", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] } ] }, { "uniprot_ac": "P09759", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] } ] }, { "uniprot_ac": "P09760", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] } ] }, { "uniprot_ac": "P0C1S8", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] } ] }, { "uniprot_ac": "P10721", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] } ] }, { "uniprot_ac": "P11362", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12931", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] } ] }, { "uniprot_ac": "P13368", "gene_name": "sev", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] } ] }, { "uniprot_ac": "P14234", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] } ] }, { "uniprot_ac": "P14616", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14680", "gene_name": "YAK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] } ] }, { "uniprot_ac": "P15127", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] } ] }, { "uniprot_ac": "P15208", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] } ] }, { "uniprot_ac": "P15209", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] } ] }, { "uniprot_ac": "P16056", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] } ] }, { "uniprot_ac": "P16092", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] } ] }, { "uniprot_ac": "P16234", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] } ] }, { "uniprot_ac": "P16277", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] } ] }, { "uniprot_ac": "P16591", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] } ] }, { "uniprot_ac": "P16879", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] } ] }, { "uniprot_ac": "P16885", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] } ] }, { "uniprot_ac": "P17948", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P18160", "gene_name": "splA", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] } ] }, { "uniprot_ac": "P18161", "gene_name": "splB", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] } ] }, { "uniprot_ac": "P18475", "gene_name": "tor", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] } ] }, { "uniprot_ac": "P20786", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] } ] }, { "uniprot_ac": "P21709", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] } ] }, { "uniprot_ac": "P21802", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] } ] }, { "uniprot_ac": "P21803", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] } ] }, { "uniprot_ac": "P21860", "gene_name": "ERBB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] } ] }, { "uniprot_ac": "P21965", "gene_name": "MCK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] } ] }, { "uniprot_ac": "P22216", "gene_name": "RAD53", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] } ] }, { "uniprot_ac": "P22455", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] } ] }, { "uniprot_ac": "P22518", "gene_name": "Clk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] } ] }, { "uniprot_ac": "P22607", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] } ] }, { "uniprot_ac": "P22681", "gene_name": "CBL", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P22681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22681" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P22681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22681" } ] } ] }, { "uniprot_ac": "P23458", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] } ] }, { "uniprot_ac": "P24062", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] } ] }, { "uniprot_ac": "P24604", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] } ] }, { "uniprot_ac": "P25911", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] } ] }, { "uniprot_ac": "P26618", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P29317", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] } ] }, { "uniprot_ac": "P29319", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] } ] }, { "uniprot_ac": "P29320", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] } ] }, { "uniprot_ac": "P29321", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] } ] }, { "uniprot_ac": "P29322", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] } ] }, { "uniprot_ac": "P29323", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] } ] }, { "uniprot_ac": "P29376", "gene_name": "LTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] } ] }, { "uniprot_ac": "P29597", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] } ] }, { "uniprot_ac": "P30530", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] } ] }, { "uniprot_ac": "P31938", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] } ] }, { "uniprot_ac": "P32350", "gene_name": "KNS1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] } ] }, { "uniprot_ac": "P32490", "gene_name": "MKK1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] } ] }, { "uniprot_ac": "P32491", "gene_name": "MKK2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] } ] }, { "uniprot_ac": "P32577", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] } ] }, { "uniprot_ac": "P34152", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] } ] }, { "uniprot_ac": "P34925", "gene_name": "RYK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] } ] }, { "uniprot_ac": "P35546", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] } ] }, { "uniprot_ac": "P35590", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] } ] }, { "uniprot_ac": "P35739", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] } ] }, { "uniprot_ac": "P35761", "gene_name": "Ttk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] } ] }, { "uniprot_ac": "P35790", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] } ] }, { "uniprot_ac": "P35916", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] } ] }, { "uniprot_ac": "P35917", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] } ] }, { "uniprot_ac": "P35918", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] } ] }, { "uniprot_ac": "P35968", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] } ] }, { "uniprot_ac": "P35969", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] } ] }, { "uniprot_ac": "P35991", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] } ] }, { "uniprot_ac": "P36506", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] } ] }, { "uniprot_ac": "P36888", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] } ] }, { "uniprot_ac": "P39688", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] } ] }, { "uniprot_ac": "P41240", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] } ] }, { "uniprot_ac": "P41241", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] } ] }, { "uniprot_ac": "P41242", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] } ] }, { "uniprot_ac": "P41243", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] } ] }, { "uniprot_ac": "P42336", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] } ] }, { "uniprot_ac": "P42338", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] } ] }, { "uniprot_ac": "P42679", "gene_name": "MATK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] } ] }, { "uniprot_ac": "P42680", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] } ] }, { "uniprot_ac": "P42681", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] } ] }, { "uniprot_ac": "P42682", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] } ] }, { "uniprot_ac": "P42684", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] } ] }, { "uniprot_ac": "P42685", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] } ] }, { "uniprot_ac": "P43403", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] } ] }, { "uniprot_ac": "P43404", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] } ] }, { "uniprot_ac": "P43405", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] } ] }, { "uniprot_ac": "P47809", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] } ] }, { "uniprot_ac": "P47810", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] } ] }, { "uniprot_ac": "P48025", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] } ] }, { "uniprot_ac": "P48736", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P50545", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] } ] }, { "uniprot_ac": "P51451", "gene_name": "BLK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] } ] }, { "uniprot_ac": "P51813", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] } ] }, { "uniprot_ac": "P52332", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] } ] }, { "uniprot_ac": "P52333", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] } ] }, { "uniprot_ac": "P53767", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] } ] }, { "uniprot_ac": "P54199", "gene_name": "MPS1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] } ] }, { "uniprot_ac": "P54350", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] } ] }, { "uniprot_ac": "P54753", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] } ] }, { "uniprot_ac": "P54754", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] } ] }, { "uniprot_ac": "P54756", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] } ] }, { "uniprot_ac": "P54757", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] } ] }, { "uniprot_ac": "P54758", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] } ] }, { "uniprot_ac": "P54759", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] } ] }, { "uniprot_ac": "P54760", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] } ] }, { "uniprot_ac": "P54761", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] } ] }, { "uniprot_ac": "P54762", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] } ] }, { "uniprot_ac": "P54763", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] } ] }, { "uniprot_ac": "P54764", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] } ] }, { "uniprot_ac": "P55144", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] } ] }, { "uniprot_ac": "P55146", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] } ] }, { "uniprot_ac": "P57097", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] } ] }, { "uniprot_ac": "P57760", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] } ] }, { "uniprot_ac": "P58801", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] } ] }, { "uniprot_ac": "P61586", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61586" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61586" } ] } ] }, { "uniprot_ac": "P62714", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62714" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62714" } ] } ] }, { "uniprot_ac": "P63000", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] } ] }, { "uniprot_ac": "P67775", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67775" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67775" } ] } ] }, { "uniprot_ac": "P70236", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] } ] }, { "uniprot_ac": "P70424", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] } ] }, { "uniprot_ac": "P70451", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] } ] }, { "uniprot_ac": "P70600", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P97504", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] } ] }, { "uniprot_ac": "P97523", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] } ] }, { "uniprot_ac": "P97793", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] } ] }, { "uniprot_ac": "Q00342", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] } ] }, { "uniprot_ac": "Q00495", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] } ] }, { "uniprot_ac": "Q00993", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] } ] }, { "uniprot_ac": "Q01134", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] } ] }, { "uniprot_ac": "Q01279", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] } ] }, { "uniprot_ac": "Q01621", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] } ] }, { "uniprot_ac": "Q01887", "gene_name": "Ryk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] } ] }, { "uniprot_ac": "Q01974", "gene_name": "ROR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] } ] }, { "uniprot_ac": "Q01986", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] } ] }, { "uniprot_ac": "Q02763", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] } ] }, { "uniprot_ac": "Q02858", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] } ] }, { "uniprot_ac": "Q03137", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] } ] }, { "uniprot_ac": "Q03142", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] } ] }, { "uniprot_ac": "Q03145", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] } ] }, { "uniprot_ac": "Q03146", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] } ] }, { "uniprot_ac": "Q03351", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] } ] }, { "uniprot_ac": "Q03526", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q04589", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] } ] }, { "uniprot_ac": "Q04736", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] } ] }, { "uniprot_ac": "Q04912", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] } ] }, { "uniprot_ac": "Q05030", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] } ] }, { "uniprot_ac": "Q05397", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06124", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] } ] }, { "uniprot_ac": "Q06187", "gene_name": "BTK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] } ] }, { "uniprot_ac": "Q06418", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] } ] }, { "uniprot_ac": "Q06806", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] } ] }, { "uniprot_ac": "Q07014", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] } ] }, { "uniprot_ac": "Q07407", "gene_name": "htl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] } ] }, { "uniprot_ac": "Q07912", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] } ] }, { "uniprot_ac": "Q08345", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] } ] }, { "uniprot_ac": "Q08881", "gene_name": "ITK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] } ] }, { "uniprot_ac": "Q09147", "gene_name": "btl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] } ] }, { "uniprot_ac": "Q12866", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] } ] }, { "uniprot_ac": "Q13163", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] } ] }, { "uniprot_ac": "Q13470", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] } ] }, { "uniprot_ac": "Q13627", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] } ] }, { "uniprot_ac": "Q13882", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] } ] }, { "uniprot_ac": "Q14289", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] } ] }, { "uniprot_ac": "Q14680", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] } ] }, { "uniprot_ac": "Q15303", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] } ] }, { "uniprot_ac": "Q15375", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] } ] }, { "uniprot_ac": "Q15569", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] } ] }, { "uniprot_ac": "Q16288", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] } ] }, { "uniprot_ac": "Q16620", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] } ] }, { "uniprot_ac": "Q16832", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24145", "gene_name": "Shark", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q24488", "gene_name": "Ror", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] } ] }, { "uniprot_ac": "Q24592", "gene_name": "hop", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] } ] }, { "uniprot_ac": "Q27324", "gene_name": "drl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] } ] }, { "uniprot_ac": "Q3UFB7", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] } ] }, { "uniprot_ac": "Q498D6", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] } ] }, { "uniprot_ac": "Q4JIM5", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] } ] }, { "uniprot_ac": "Q4KM97", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] } ] }, { "uniprot_ac": "Q4KSH6", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { "uniprot_ac": "Q4V8A3", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] } ] }, { "uniprot_ac": "Q501W1", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q501W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q501W1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q501W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q501W1" } ] } ] }, { "uniprot_ac": "Q504Y2", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] } ] }, { "uniprot_ac": "Q54BC9", "gene_name": "dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] } ] }, { "uniprot_ac": "Q54G28", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] } ] }, { "uniprot_ac": "Q54I36", "gene_name": "pyk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] } ] }, { "uniprot_ac": "Q54N73", "gene_name": "7tmk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] } ] }, { "uniprot_ac": "Q54QV3", "gene_name": "yakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] } ] }, { "uniprot_ac": "Q54R58", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] } ] }, { "uniprot_ac": "Q552C6", "gene_name": "zak2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] } ] }, { "uniprot_ac": "Q55CL6", "gene_name": "mekA", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] } ] }, { "uniprot_ac": "Q5FVG7", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] } ] }, { "uniprot_ac": "Q5JZY3", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] } ] }, { "uniprot_ac": "Q5RJI4", "gene_name": "Pkdcc", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] } ] }, { "uniprot_ac": "Q5U2X5", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] } ] }, { "uniprot_ac": "Q5U4C9", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] } ] }, { "uniprot_ac": "Q60629", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60629" } ] } ] }, { "uniprot_ac": "Q60750", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] } ] }, { "uniprot_ac": "Q60751", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] } ] }, { "uniprot_ac": "Q60805", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60805" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60805" } ] } ] }, { "uniprot_ac": "Q61006", "gene_name": "Musk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61006" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61006" } ] } ] }, { "uniprot_ac": "Q61214", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] } ] }, { "uniprot_ac": "Q61526", "gene_name": "Erbb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61526" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61526" } ] } ] }, { "uniprot_ac": "Q61527", "gene_name": "Erbb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61527" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61527" } ] } ] }, { "uniprot_ac": "Q61772", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61772" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61772" } ] } ] }, { "uniprot_ac": "Q61846", "gene_name": "Melk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61846" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q61846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61846" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61846" } ] } ] }, { "uniprot_ac": "Q61851", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61851" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61851" } ] } ] }, { "uniprot_ac": "Q62120", "gene_name": "Jak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62120" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62120" } ] } ] }, { "uniprot_ac": "Q62137", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62137" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62137" } ] } ] }, { "uniprot_ac": "Q62190", "gene_name": "Mst1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62190", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62190" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62190", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62190" } ] } ] }, { "uniprot_ac": "Q62270", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62270" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62270" } ] } ] }, { "uniprot_ac": "Q62371", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62371" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62371" } ] } ] }, { "uniprot_ac": "Q62413", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] } ] }, { "uniprot_ac": "Q62662", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] } ] }, { "uniprot_ac": "Q62689", "gene_name": "Jak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62689" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62689" } ] } ] }, { "uniprot_ac": "Q62799", "gene_name": "Erbb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] } ] }, { "uniprot_ac": "Q62838", "gene_name": "Musk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] } ] }, { "uniprot_ac": "Q62844", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] } ] }, { "uniprot_ac": "Q62862", "gene_name": "Map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] } ] }, { "uniprot_ac": "Q62956", "gene_name": "Erbb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] } ] }, { "uniprot_ac": "Q63116", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] } ] }, { "uniprot_ac": "Q63117", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] } ] }, { "uniprot_ac": "Q63132", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] } ] }, { "uniprot_ac": "Q63184", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] } ] }, { "uniprot_ac": "Q63272", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] } ] }, { "uniprot_ac": "Q63470", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] } ] }, { "uniprot_ac": "Q63474", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] } ] }, { "uniprot_ac": "Q63572", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] } ] }, { "uniprot_ac": "Q63604", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] } ] }, { "uniprot_ac": "Q63802", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] } ] }, { "uniprot_ac": "Q63932", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] } ] }, { "uniprot_ac": "Q64434", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64434" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64434" } ] } ] }, { "uniprot_ac": "Q64716", "gene_name": "Insrr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] } ] }, { "uniprot_ac": "Q64725", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] } ] }, { "uniprot_ac": "Q66JT0", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q66JT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q66JT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT0" } ] } ] }, { "uniprot_ac": "Q6J9G0", "gene_name": "STYK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6J9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6J9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G0" } ] } ] }, { "uniprot_ac": "Q6J9G1", "gene_name": "Styk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6J9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6J9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J9G1" } ] } ] }, { "uniprot_ac": "Q6P6U0", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] } ] }, { "uniprot_ac": "Q6VNS1", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] } ] }, { "uniprot_ac": "Q6XUX1", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] } ] }, { "uniprot_ac": "Q6XUX2", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX2" } ] } ] }, { "uniprot_ac": "Q6XUX3", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX3" } ] } ] }, { "uniprot_ac": "Q75JK0", "gene_name": "zakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] } ] }, { "uniprot_ac": "Q76NV1", "gene_name": "dyrk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] } ] }, { "uniprot_ac": "Q78DX7", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q78DX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78DX7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q78DX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78DX7" } ] } ] }, { "uniprot_ac": "Q7KJ08", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KJ08" } ] } ] }, { "uniprot_ac": "Q7KT06", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KT06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KT06" } ] } ] }, { "uniprot_ac": "Q8BI55", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] } ] }, { "uniprot_ac": "Q8BYG9", "gene_name": "Epha10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] } ] }, { "uniprot_ac": "Q8CBF3", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] } ] }, { "uniprot_ac": "Q8CE90", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q8VCT9", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] } ] }, { "uniprot_ac": "Q91ZT1", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q91ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q91ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZT1" } ] } ] }, { "uniprot_ac": "Q922K9", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] } ] }, { "uniprot_ac": "Q922Y0", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] } ] }, { "uniprot_ac": "Q924U5", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] } ] }, { "uniprot_ac": "Q925D6", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] } ] }, { "uniprot_ac": "Q92630", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q92630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92630" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q92630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92630" } ] } ] }, { "uniprot_ac": "Q92835", "gene_name": "INPP5D", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] } ] }, { "uniprot_ac": "Q96KB5", "gene_name": "PBK", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96KB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KB5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q96KB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KB5" } ] } ] }, { "uniprot_ac": "Q96S53", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96S53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96S53" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q96S53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96S53" } ] } ] }, { "uniprot_ac": "Q99ML2", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] } ] }, { "uniprot_ac": "Q9H3Y6", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] } ] }, { "uniprot_ac": "Q9HAZ1", "gene_name": "CLK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] } ] }, { "uniprot_ac": "Q9I7F7", "gene_name": "Ack-like", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] } ] }, { "uniprot_ac": "Q9JJ78", "gene_name": "Pbk", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJ78" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q9JJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJ78" } ] } ] }, { "uniprot_ac": "Q9NR20", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9NR20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR20" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9NR20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR20" } ] } ] }, { "uniprot_ac": "Q9QVP9", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9QVP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QVP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9QVP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QVP9" } ] } ] }, { "uniprot_ac": "Q9R117", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9R117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R117" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9R117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R117" } ] } ] }, { "uniprot_ac": "Q9UF33", "gene_name": "EPHA6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9UF33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UF33" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9UF33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UF33" } ] } ] }, { "uniprot_ac": "Q9UIG0", "gene_name": "BAZ1B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9UIG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UIG0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9UIG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UIG0" } ] } ] }, { "uniprot_ac": "Q9UM73", "gene_name": "ALK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9UM73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UM73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9UM73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UM73" } ] } ] }, { "uniprot_ac": "Q9V3D5", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9V3D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3D5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9V3D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3D5" } ] } ] }, { "uniprot_ac": "Q9V422", "gene_name": "dnt", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V422" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V422" } ] } ] }, { "uniprot_ac": "Q9V6K3", "gene_name": "Nrk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V6K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6K3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9V6K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V6K3" } ] } ] }, { "uniprot_ac": "Q9V9J3", "gene_name": "Src42A", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9V9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V9J3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9V9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V9J3" } ] } ] }, { "uniprot_ac": "Q9VBW3", "gene_name": "Cad96Ca", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VBW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBW3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VBW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBW3" } ] } ] }, { "uniprot_ac": "Q9VE06", "gene_name": "cdi", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] } ] }, { "uniprot_ac": "Q9VJ04", "gene_name": "Dmel\\CG10702", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9VJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ04" } ] } ] }, { "uniprot_ac": "Q9VPC0", "gene_name": "Pitslre", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] } ] }, { "uniprot_ac": "Q9VZA8", "gene_name": "Tie", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VZA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZA8" } ] } ] }, { "uniprot_ac": "Q9VZI2", "gene_name": "Ack", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] } ] }, { "uniprot_ac": "Q9WTL4", "gene_name": "Insrr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9WTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTL4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9WTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTL4" } ] } ] }, { "uniprot_ac": "Q9WUD9", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9WUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUD9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9WUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUD9" } ] } ] }, { "uniprot_ac": "Q9WVS7", "gene_name": "Map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WVS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q9WVS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS7" } ] } ] }, { "uniprot_ac": "Q9Y463", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y463" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9Y463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y463" } ] } ] }, { "uniprot_ac": "Q9Z138", "gene_name": "Ror2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9Z138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z138" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q9Z138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z138" } ] } ] }, { "uniprot_ac": "Q9Z188", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Z188", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z188" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9Z188", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z188" } ] } ] }, { "uniprot_ac": "Q9Z277", "gene_name": "Baz1b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9Z277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z277" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9Z277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z277" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11, 21, 26, 27, 28, 30, 32, 40, 44, 45, 111, 194, 195, 222, 223, 336, 345, 426, 446, 537 ], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 9, "end_pos": 11 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 22 }, { "field": "total_sites", "count": 20 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 308 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }