{
    "uniprot_canonical_ac": "P07670-1",
    "uniprot_ac": "P07670",
    "uniprot_id": "PYRD_DICDI",
    "mass": {
        "chemical_mass": 40520.0,
        "monoisotopic_mass": 40520.0
    },
    "refseq": {
        "ac": "XP_643195",
        "name": "dihydroorotate dehydrogenase",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643195"
    },
    "gene_names": [
        {
            "name": "pyr4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P07670",
            "id": "P07670"
        },
        {
            "name": "DDB_G0276331",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P07670",
            "id": "P07670"
        },
        {
            "name": "pyr4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643195",
            "id": "XP_643195"
        }
    ],
    "protein_names": [
        {
            "name": "Dihydroorotate dehydrogenase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P07670"
        },
        {
            "name": "1.3.-.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P07670"
        },
        {
            "name": "DHODase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P07670"
        },
        {
            "name": "DHOD",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P07670"
        },
        {
            "name": "DHOdehase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P07670"
        },
        {
            "name": "Dihydroorotate oxidase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P07670"
        },
        {
            "name": "dihydroorotate dehydrogenase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643195",
            "id": "XP_643195"
        },
        {
            "name": "dihydroorotate oxidase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643195",
            "id": "XP_643195"
        }
    ],
    "function": [
        {
            "annotation": "Catalyzes the conversion of dihydroorotate to orotate (PubMed:2996629). Participates in the pyrimidine biosynthetic pathway (PubMed:2996629).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P07670",
                    "url": "https://www.uniprot.org/uniprot/P07670#function"
                },
                {
                    "database": "PubMed",
                    "id": "2996629",
                    "url": "https://glygen.org/publication/PubMed/2996629"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Dictyostelium discoideum",
            "taxid": 44689,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P07670",
                    "url": "https://www.uniprot.org/uniprot/P07670"
                }
            ],
            "common_name": "Cellular slime molds"
        }
    ],
    "gene": [
        {
            "name": "pyr4",
            "url": "https://www.uniprot.org/uniprot/P07670",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "cd02810",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02810",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "DDB_G0276331",
            "url": "http://dictybase.org/gene/DDB_G0276331",
            "database": "dictyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "8620469",
            "url": "https://www.ncbi.nlm.nih.gov/gene/8620469",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR005720",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005720",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013785",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ddi:DDB_G0276331",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0276331",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "CPNEGHN",
            "url": "https://omabrowser.org/oma/group/CPNEGHN/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48109",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48109",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48109:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48109:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01180",
            "url": "http://pfam.xfam.org/family/PF01180",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P07670",
            "url": "http://purl.obolibrary.org/obo/PR_P07670",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "XP_643195",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643195",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "18073",
            "url": "https://www.rhea-db.org/rhea/18073",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "P07670",
            "url": "https://www.uniprot.org/uniprot/P07670",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P07670-1",
            "url": "https://www.uniprot.org/uniprot/P07670-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEWPINKPIYDINKSWEDNLENGPFIEGYKKVDRNDNKDPSKYIDFLGQKLASPIGVPAGPLLNSQWVKFALEAGFDLPTYKTIRSHEHFGHPVPNVMYLDLESEDKQFTKSDSGSTLHATQTIPTTMDQLAITNSFGMPSMGKEYLYKDIALAHSYLGSGQSMIVSITGTASSAHDFLQDFVDTVRIACDAGAKMVEVNYSCPNVVTGEGQIYHNPDAVYEISSTLVKELSSKNIPLIIKVGVMDDLEKMERLFQQAERAGVAAIAGINTLSMKVTDKITGEPSLGASRLTSGVCGAPIRSAALDWVSTASSIIKKQNSKLKLLGCGGIVKPEHFDDFLNSGADIAMSATGLMWDPYIAMKWHNNNKNN",
        "length": 370,
        "header": "sp|P07670-1|PYRD_DICDI Isoform 1 of Dihydroorotate dehydrogenase  OS=Dictyostelium discoideum OX=44689 GN=pyr4 PE=1 SV=2 CANONICAL=P07670-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P07670-1",
            "url": "",
            "sequence": {
                "sequence": "MEWPINKPIYDINKSWEDNLENGPFIEGYKKVDRNDNKDPSKYIDFLGQKLASPIGVPAGPLLNSQWVKFALEAGFDLPTYKTIRSHEHFGHPVPNVMYLDLESEDKQFTKSDSGSTLHATQTIPTTMDQLAITNSFGMPSMGKEYLYKDIALAHSYLGSGQSMIVSITGTASSAHDFLQDFVDTVRIACDAGAKMVEVNYSCPNVVTGEGQIYHNPDAVYEISSTLVKELSSKNIPLIIKVGVMDDLEKMERLFQQAERAGVAAIAGINTLSMKVTDKITGEPSLGASRLTSGVCGAPIRSAALDWVSTASSIIKKQNSKLKLLGCGGIVKPEHFDDFLNSGADIAMSATGLMWDPYIAMKWHNNNKNN",
                "length": 370,
                "header": "sp|P07670-1|PYRD_DICDI Isoform 1 of Dihydroorotate dehydrogenase  OS=Dictyostelium discoideum OX=44689 GN=pyr4 PE=1 SV=2 CANONICAL=P07670-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.",
            "journal": "Nature",
            "date": "2002",
            "authors": "Gl\u00f6ckner Gernot, Eichinger Ludwig, Szafranski Karol, Pachebat Justin A, Bankier Alan T, Dear Paul H, Lehmann R\u00fcdiger, Baumgart Cornelia, Parra Gen\u00eds, Abril Josep F, Guig\u00f3 Roderic, Kumpf Kai, Tunggal Budi, Cox Edward, Quail Michael A, Platzer Matthias, Rosenthal Andr\u00e9, Noegel Angelika A,",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P07670",
                    "url": "https://www.uniprot.org/uniprot/P07670"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12097910",
                    "url": "https://glygen.org/publication/PubMed/12097910"
                }
            ]
        },
        {
            "title": "The genome of the social amoeba Dictyostelium discoideum.",
            "journal": "Nature",
            "date": "2005",
            "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P07670",
                    "url": "https://www.uniprot.org/uniprot/P07670"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15875012",
                    "url": "https://glygen.org/publication/PubMed/15875012"
                }
            ]
        },
        {
            "title": "Sequence analysis of a Dictyostelium discoideum gene coding for an active dihydroorotate dehydrogenase in yeast.",
            "journal": "Biochimie",
            "date": "1985-06",
            "authors": "Jacquet M, Kalekine M, Boy-Marcotte E",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P07670",
                    "url": "https://www.uniprot.org/uniprot/P07670"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2996629",
                    "url": "https://glygen.org/publication/PubMed/2996629"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ddi:DDB_G0276331",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0276331",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P07670",
                                "url": "https://www.uniprot.org/uniprot/P07670"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "dihydroorotate dehydrogenase activity",
                        "id": "GO:0004152",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004152",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P07670",
                                "url": "https://www.uniprot.org/uniprot/P07670"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "'de novo' pyrimidine nucleobase biosynthetic process",
                        "id": "GO:0006207",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006207",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P07670",
                                "url": "https://www.uniprot.org/uniprot/P07670"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "'de novo' UMP biosynthetic process",
                        "id": "GO:0044205",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044205",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P07670",
                                "url": "https://www.uniprot.org/uniprot/P07670"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 13,
            "end_pos": 15,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 200,
            "end_pos": 202,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "18073",
            "name": "",
            "equation": "(S)-dihydroorotate + A = AH2 + orotate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P07670-1"
            ],
            "evidence": [
                {
                    "id": "18073",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/18073"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "P07670",
            "gene_name": "pyr4",
            "activity": [
                {
                    "ec_number": "1.3.-.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P07670",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P07670"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 13,
                "end_pos": 15
            },
            {
                "start_pos": 200,
                "end_pos": 202
            }
        ]
    },
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 3
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}