{ "uniprot_canonical_ac": "P07332-1", "uniprot_ac": "P07332", "uniprot_id": "FES_HUMAN", "mass": { "chemical_mass": 93497.0, "monoisotopic_mass": 93497.0 }, "refseq": { "ac": "NP_001137255", "name": "tyrosine-protein kinase Fes/Fps isoform 2", "summary": "This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255" }, "gene_names": [ { "name": "FES", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07332", "id": "P07332" }, { "name": "FES", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255", "id": "NP_001137255" }, { "name": "FPS", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255", "id": "NP_001137255" }, { "name": "FPS", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07332", "id": "P07332" } ], "protein_names": [ { "name": "Tyrosine-protein kinase Fes/Fps", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07332" }, { "name": "2.7.10.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07332" }, { "name": "Feline sarcoma/Fujinami avian sarcoma oncogene homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07332" }, { "name": "Oncogene FES, feline sarcoma virus; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; p93c-fes; feline sarcoma oncogene; proto-oncogene tyrosine-protein kinase Fes/Fps; proto-oncogene c-Fes; proto-oncogene c-Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255", "id": "NP_001137255" }, { "name": "Proto-oncogene c-Fes", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07332" }, { "name": "Proto-oncogene c-Fps", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07332" }, { "name": "p93c-fes", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07332" }, { "name": "tyrosine-protein kinase Fes/Fps isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255", "id": "NP_001137255" } ], "function": [ { "annotation": "Identification of FES as a Novel Radiosensitizing Target in Human Cancers.", "evidence": [ { "database": "RefSeq", "id": "NP_001137255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255" }, { "database": "PubMed", "id": "31573955", "url": "https://glygen.org/publication/PubMed/31573955" } ] }, { "annotation": "The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001137255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255" }, { "database": "PubMed", "id": "36321446", "url": "https://glygen.org/publication/PubMed/36321446" } ] }, { "annotation": "This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_001137255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255" } ] }, { "annotation": "This study supports the critical role of FER and FES tyrosine kinase fusions in the pathogenesis of follicular T-cell lymphoma and provides additional evidence that these can drive follicular T-cell lymphoma in the absence of RHOA mutations.", "evidence": [ { "database": "RefSeq", "id": "NP_001137255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255" }, { "database": "PubMed", "id": "31746983", "url": "https://glygen.org/publication/PubMed/31746983" } ] }, { "annotation": "Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332#function" }, { "database": "PubMed", "id": "15302586", "url": "https://glygen.org/publication/PubMed/15302586" }, { "database": "PubMed", "id": "18046454", "url": "https://glygen.org/publication/PubMed/18046454" }, { "database": "PubMed", "id": "20111072", "url": "https://glygen.org/publication/PubMed/20111072" }, { "database": "PubMed", "id": "17595334", "url": "https://glygen.org/publication/PubMed/17595334" }, { "database": "PubMed", "id": "8955135", "url": "https://glygen.org/publication/PubMed/8955135" }, { "database": "PubMed", "id": "19051325", "url": "https://glygen.org/publication/PubMed/19051325" }, { "database": "PubMed", "id": "16455651", "url": "https://glygen.org/publication/PubMed/16455651" }, { "database": "PubMed", "id": "19001085", "url": "https://glygen.org/publication/PubMed/19001085" }, { "database": "PubMed", "id": "15485904", "url": "https://glygen.org/publication/PubMed/15485904" }, { "database": "PubMed", "id": "11509660", "url": "https://glygen.org/publication/PubMed/11509660" }, { "database": "PubMed", "id": "2656706", "url": "https://glygen.org/publication/PubMed/2656706" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 113, "end_pos": 114, "sequence_org": "RK", "sequence_mut": "EE", "comment": "Reduced binding to membranes containing phosphoinositides.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19001085", "url": "https://glygen.org/publication/PubMed/19001085" } ] }, { "start_pos": 113, "end_pos": 114, "sequence_org": "RK", "sequence_mut": "QQ", "comment": "Reduced binding to membranes containing phosphoinositides.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19001085", "url": "https://glygen.org/publication/PubMed/19001085" } ] }, { "start_pos": 145, "end_pos": 145, "sequence_org": "L", "sequence_mut": "P", "comment": "Constitutively activated kinase that can act as oncogene. Promotes myeloid cell survival and proliferation.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "15485904", "url": "https://glygen.org/publication/PubMed/15485904" }, { "database": "PubMed", "id": "11509660", "url": "https://glygen.org/publication/PubMed/11509660" } ] }, { "start_pos": 334, "end_pos": 334, "sequence_org": "L", "sequence_mut": "P", "comment": "Abolishes autophosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "11509660", "url": "https://glygen.org/publication/PubMed/11509660" } ] }, { "start_pos": 463, "end_pos": 463, "sequence_org": "G", "sequence_mut": "V", "comment": "Abolishes kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "18775312", "url": "https://glygen.org/publication/PubMed/18775312" } ] }, { "start_pos": 483, "end_pos": 483, "sequence_org": "R", "sequence_mut": "M", "comment": "Abolishes pTyr binding. Abolishes association with microtubules. Abolishes autophosphorylation. Reduced kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "18775312", "url": "https://glygen.org/publication/PubMed/18775312" }, { "database": "PubMed", "id": "15485904", "url": "https://glygen.org/publication/PubMed/15485904" } ] }, { "start_pos": 590, "end_pos": 590, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolishes kinase activity. Fails to inhibit proliferation of melanoma cells.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "28463229", "url": "https://glygen.org/publication/PubMed/28463229" }, { "database": "PubMed", "id": "15485904", "url": "https://glygen.org/publication/PubMed/15485904" } ] }, { "start_pos": 704, "end_pos": 704, "sequence_org": "M", "sequence_mut": "V", "comment": "Reduced autophosphorylation and strongly reduced kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "15867340", "url": "https://glygen.org/publication/PubMed/15867340" }, { "database": "PubMed", "id": "16455651", "url": "https://glygen.org/publication/PubMed/16455651" } ] }, { "start_pos": 706, "end_pos": 706, "sequence_org": "R", "sequence_mut": "Q", "comment": "Negligible effect on autophosphorylation and kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "15867340", "url": "https://glygen.org/publication/PubMed/15867340" }, { "database": "PubMed", "id": "16455651", "url": "https://glygen.org/publication/PubMed/16455651" } ] }, { "start_pos": 713, "end_pos": 713, "sequence_org": "Y", "sequence_mut": "F", "comment": "Reduces kinase activity by over 90%.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "7687763", "url": "https://glygen.org/publication/PubMed/7687763" } ] }, { "start_pos": 743, "end_pos": 743, "sequence_org": "V", "sequence_mut": "M", "comment": "Strongly reduced autophosphorylation and kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "15867340", "url": "https://glygen.org/publication/PubMed/15867340" }, { "database": "PubMed", "id": "16455651", "url": "https://glygen.org/publication/PubMed/16455651" } ] }, { "start_pos": 759, "end_pos": 759, "sequence_org": "S", "sequence_mut": "F", "comment": "Reduced autophosphorylation and strongly reduced kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "15867340", "url": "https://glygen.org/publication/PubMed/15867340" }, { "database": "PubMed", "id": "16455651", "url": "https://glygen.org/publication/PubMed/16455651" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "67.08", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "56.68", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "71.83", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "92.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "79.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "76.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "87.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "51.77", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "80.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "90.4", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "86.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P07332", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07332" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P07332", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07332" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P07332", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07332" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" } ], "common_name": "Human" } ], "gene": [ { "name": "FES", "url": "https://www.uniprot.org/uniprot/P07332", "locus": { "chromosome": "15", "start_pos": 90895776, "end_pos": 90883695, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000182511", "url": "https://www.ensembl.org/id/ENSG00000182511" } ] } } ], "crossref": [ { "id": "ENSG00000182511", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182511", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.7.10.2", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.10.2&UniProtAcc=P07332", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd05084", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05084", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07685", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07685", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10361", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10361", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL5455", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL5455", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "FES", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=FES", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "2242", "url": "https://www.ncbi.nlm.nih.gov/gene/2242", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3657", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3657", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P07332", "url": "https://www.ebi.ac.uk/intact/interactors/id:P07332*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:2242", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2242", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "190030", "url": "http://www.omim.org/entry/190030", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P07332", "url": "https://www.nextprot.org/entry/NX_P07332", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "QNTENMY", "url": "https://omabrowser.org/oma/group/QNTENMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2903566at2759", "url": "http://www.orthodb.org/?query=2903566at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15735", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15735", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15735:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15735:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24418", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24418", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24418:SF197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24418:SF197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1WQU", "url": "https://www.rcsb.org/structure/1WQU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2DCR", "url": "https://www.rcsb.org/structure/2DCR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3BKB", "url": "https://www.rcsb.org/structure/3BKB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3CBL", "url": "https://www.rcsb.org/structure/3CBL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3CD3", "url": "https://www.rcsb.org/structure/3CD3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4DYL", "url": "https://www.rcsb.org/structure/4DYL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4E93", "url": "https://www.rcsb.org/structure/4E93", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6JMF", "url": "https://www.rcsb.org/structure/6JMF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7T1K", "url": "https://www.rcsb.org/structure/7T1K", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7T1L", "url": "https://www.rcsb.org/structure/7T1L", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00017", "url": "http://pfam.xfam.org/family/PF00017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00611", "url": "http://pfam.xfam.org/family/PF00611", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "http://pfam.xfam.org/family/PF07714", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P07332", "url": "https://pharos.nih.gov/targets/P07332", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P07332", "url": "http://purl.obolibrary.org/obo/PR_P07332", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001137255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137255", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "C9J3W6", "url": "https://www.uniprot.org/uniprot/C9J3W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J3W6-1", "url": "https://www.uniprot.org/uniprot/C9J3W6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EMJ7", "url": "https://www.uniprot.org/uniprot/E7EMJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EMJ7-1", "url": "https://www.uniprot.org/uniprot/E7EMJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7ENM8", "url": "https://www.uniprot.org/uniprot/E7ENM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7ENM8-1", "url": "https://www.uniprot.org/uniprot/E7ENM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PGC7", "url": "https://www.uniprot.org/uniprot/E9PGC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PGC7-1", "url": "https://www.uniprot.org/uniprot/E9PGC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PIJ7", "url": "https://www.uniprot.org/uniprot/E9PIJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PIJ7-1", "url": "https://www.uniprot.org/uniprot/E9PIJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YNN8", "url": "https://www.uniprot.org/uniprot/H0YNN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YNN8-1", "url": "https://www.uniprot.org/uniprot/H0YNN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YNT6", "url": "https://www.uniprot.org/uniprot/H0YNT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YNT6-1", "url": "https://www.uniprot.org/uniprot/H0YNT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07332-1", "url": "https://www.uniprot.org/uniprot/P07332-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07332-2", "url": "https://www.uniprot.org/uniprot/P07332-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07332-3", "url": "https://www.uniprot.org/uniprot/P07332-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07332-4", "url": "https://www.uniprot.org/uniprot/P07332-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR", "length": 822, "header": "sp|P07332-1|FES_HUMAN Isoform 1 of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=3 CANONICAL=P07332-1" }, "isoforms": [ { "isoform_ac": "C9J3W6-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDR", "length": 42, "header": "tr|C9J3W6-1|FES_HUMAN Computationally mapped isoform of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=1 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90885171, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416779.1", "url": "https://www.ensembl.org/id/ENST00000416779.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000410477.1", "url": "https://www.ensembl.org/id/ENSP00000410477.1" } ] } }, { "isoform_ac": "E7EMJ7-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALAR", "length": 147, "header": "tr|E7EMJ7-1|FES_HUMAN Computationally mapped isoform of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=1 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90887014, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452243.5", "url": "https://www.ensembl.org/id/ENST00000452243.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000392696.1", "url": "https://www.ensembl.org/id/ENSP00000392696.1" } ] } }, { "isoform_ac": "E7ENM8-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARSSPSTSSWSLCRGSSPPAGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR", "length": 681, "header": "tr|E7ENM8-1|E7ENM8_HUMAN Computationally mapped isoform of Tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=FES PE=1 SV=1 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90895555, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394302.5", "url": "https://www.ensembl.org/id/ENST00000394302.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000377839.1", "url": "https://www.ensembl.org/id/ENSP00000377839.1" } ] } }, { "isoform_ac": "E9PGC7-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRK", "length": 114, "header": "tr|E9PGC7-1|E9PGC7_HUMAN Computationally mapped isoform of FES proto-oncogene, tyrosine kinase OS=Homo sapiens OX=9606 GN=FES PE=1 SV=8 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90885540, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000443697.1", "url": "https://www.ensembl.org/id/ENST00000443697.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000395425.1", "url": "https://www.ensembl.org/id/ENSP00000395425.1" } ] } }, { "isoform_ac": "E9PIJ7-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQAHAPSEWRLLTPGPLPCRTCTDWKGKAFLAFLCSSTTY", "length": 545, "header": "tr|E9PIJ7-1|E9PIJ7_HUMAN Computationally mapped isoform of FES proto-oncogene, tyrosine kinase OS=Homo sapiens OX=9606 GN=FES PE=1 SV=1 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90891614, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000464684.5", "url": "https://www.ensembl.org/id/ENST00000464684.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435811.1", "url": "https://www.ensembl.org/id/ENSP00000435811.1" } ] } }, { "isoform_ac": "H0YNN8-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAK", "length": 169, "header": "tr|H0YNN8-1|H0YNN8_HUMAN Computationally mapped isoform of FES proto-oncogene, tyrosine kinase OS=Homo sapiens OX=9606 GN=FES PE=1 SV=1 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90887209, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000559355.5", "url": "https://www.ensembl.org/id/ENST00000559355.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454089.1", "url": "https://www.ensembl.org/id/ENSP00000454089.1" } ] } }, { "isoform_ac": "H0YNT6-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQVGLYGTLVGAGCICLLLPLLGALWGSGWRSGRPMLGSHCAPLPASPICAV", "length": 121, "header": "tr|H0YNT6-1|FES_HUMAN Computationally mapped isoform of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=1 CANONICAL=P07332-1" }, "locus": {} }, { "isoform_ac": "P07332-1", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR", "length": 822, "header": "sp|P07332-1|FES_HUMAN Isoform 1 of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=3 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90895555, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000328850.8", "url": "https://www.ensembl.org/id/ENST00000328850.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000331504.3", "url": "https://www.ensembl.org/id/ENSP00000331504.3" } ] } }, { "isoform_ac": "P07332-2", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR", "length": 694, "header": "sp|P07332-2|FES_HUMAN Isoform 2 of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=3 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90895555, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414248.6", "url": "https://www.ensembl.org/id/ENST00000414248.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000414629.2", "url": "https://www.ensembl.org/id/ENSP00000414629.2" } ] } }, { "isoform_ac": "P07332-3", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR", "length": 764, "header": "sp|P07332-3|FES_HUMAN Isoform 3 of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=3 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90895555, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394300.7", "url": "https://www.ensembl.org/id/ENST00000394300.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000377837.3", "url": "https://www.ensembl.org/id/ENSP00000377837.3" } ] } }, { "isoform_ac": "P07332-4", "url": "", "sequence": { "sequence": "MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR", "length": 752, "header": "sp|P07332-4|FES_HUMAN Isoform 4 of Tyrosine-protein kinase Fes/Fps OS=Homo sapiens OX=9606 GN=FES PE=1 SV=3 CANONICAL=P07332-1" }, "locus": { "chromosome": "15", "start_pos": 90895555, "end_pos": 90885046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000444422.2", "url": "https://www.ensembl.org/id/ENST00000444422.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000400868.2", "url": "https://www.ensembl.org/id/ENSP00000400868.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 261, "end_pos": 261, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Tyr261" }, { "start_pos": 408, "end_pos": 408, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Ser408" }, { "start_pos": 411, "end_pos": 411, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Ser411" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "20111072", "url": "https://glygen.org/publication/PubMed/20111072" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Thr421" }, { "start_pos": 64, "end_pos": 64, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Ser64" }, { "start_pos": 67, "end_pos": 67, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Ser67" }, { "start_pos": 713, "end_pos": 713, "kinase_uniprot_canonical_ac": "P07332-1", "kinase_gene_name": "FES", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" }, { "database": "PubMed", "id": "8663427", "url": "https://glygen.org/publication/PubMed/8663427" }, { "database": "PubMed", "id": "7687763", "url": "https://glygen.org/publication/PubMed/7687763" }, { "database": "PubMed", "id": "8955135", "url": "https://glygen.org/publication/PubMed/8955135" }, { "database": "phospho.ELM", "id": "P07332", "url": "http://phospho.elm.eu.org/byAccession/P07332.html" }, { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "15485904", "url": "https://glygen.org/publication/PubMed/15485904" } ], "site_lbl": "Tyr713" }, { "start_pos": 713, "end_pos": 713, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by autocatalysis", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "IntAct", "id": "P07332", "url": "https://www.ebi.ac.uk/intact/interactors/id:P07332*" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" }, { "database": "PubMed", "id": "18046454", "url": "https://glygen.org/publication/PubMed/18046454" }, { "database": "PubMed", "id": "7687763", "url": "https://glygen.org/publication/PubMed/7687763" }, { "database": "PubMed", "id": "8334128", "url": "https://glygen.org/publication/PubMed/8334128" }, { "database": "PubMed", "id": "18775312", "url": "https://glygen.org/publication/PubMed/18775312" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "PubMed", "id": "19382747", "url": "https://glygen.org/publication/PubMed/19382747" } ], "site_lbl": "Tyr713" }, { "start_pos": 716, "end_pos": 716, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19369195", "url": "https://glygen.org/publication/PubMed/19369195" }, { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" } ], "site_lbl": "Ser716" }, { "start_pos": 811, "end_pos": 811, "kinase_uniprot_canonical_ac": "P07332-1", "kinase_gene_name": "FES", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07332", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07332" }, { "database": "PubMed", "id": "8663427", "url": "https://glygen.org/publication/PubMed/8663427" }, { "database": "phospho.ELM", "id": "P07332", "url": "http://phospho.elm.eu.org/byAccession/P07332.html" }, { "database": "PubMed", "id": "7687763", "url": "https://glygen.org/publication/PubMed/7687763" } ], "site_lbl": "Tyr811" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Gatti A, Huang Z, Tuazon PT, Traugh JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954" } ], "reference": [ { "type": "PubMed", "id": "10075701", "url": "https://glygen.org/publication/PubMed/10075701" } ] }, { "title": "STAT protein recruitment and activation in c-Kit deletion mutants.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Brizzi MF, Dentelli P, Rosso A, Yarden Y, Pegoraro L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10358045", "url": "https://glygen.org/publication/PubMed/10358045" } ] }, { "title": "Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.", "journal": "The Biochemical journal", "date": "1999", "authors": "Thommes K, Lennartsson J, Carlberg M, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10377264", "url": "https://glygen.org/publication/PubMed/10377264" } ] }, { "title": "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor.", "journal": "Blood", "date": "1999", "authors": "Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10397721", "url": "https://glygen.org/publication/PubMed/10397721" } ] }, { "title": "Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction.", "journal": "Oncogene", "date": "1999", "authors": "Lennartsson J, Blume-Jensen P, Hermanson M, Ponten E, Carlberg M, Ronnstrand L", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10523831", "url": "https://glygen.org/publication/PubMed/10523831" } ] }, { "title": "Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts.", "journal": "Oncogene", "date": "1999", "authors": "Caruana G, Cambareri AC, Ashman LK", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10523834", "url": "https://glygen.org/publication/PubMed/10523834" } ] }, { "title": "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.", "journal": "Nature cell biology", "date": "1999", "authors": "Edwards DC, Sanders LC, Bokoch GM, Gill GN", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954" } ], "reference": [ { "type": "PubMed", "id": "10559936", "url": "https://glygen.org/publication/PubMed/10559936" } ] }, { "title": "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10679268", "url": "https://glygen.org/publication/PubMed/10679268" } ] }, { "title": "Semaphorins and their receptors in vertebrates and invertebrates.", "journal": "Current opinion in neurobiology", "date": "2000", "authors": "Raper JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955" } ], "reference": [ { "type": "PubMed", "id": "10679438", "url": "https://glygen.org/publication/PubMed/10679438" } ] }, { "title": "Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433557" } ], "reference": [ { "type": "PubMed", "id": "10884405", "url": "https://glygen.org/publication/PubMed/10884405" } ] }, { "title": "Molecular basis of semaphorin-mediated axon guidance.", "journal": "Journal of neurobiology", "date": "2000", "authors": "Nakamura F, Kalb RG, Strittmatter SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955" } ], "reference": [ { "type": "PubMed", "id": "10934324", "url": "https://glygen.org/publication/PubMed/10934324" } ] }, { "title": "Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.", "journal": "Nature neuroscience", "date": "2001", "authors": "Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954" } ], "reference": [ { "type": "PubMed", "id": "11276226", "url": "https://glygen.org/publication/PubMed/11276226" } ] }, { "title": "The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Chong C, Tan L, Lim L, Manser E", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954" } ], "reference": [ { "type": "PubMed", "id": "11278486", "url": "https://glygen.org/publication/PubMed/11278486" } ] }, { "title": "Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking.", "journal": "Exp. 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"https://www.uniprot.org/uniprot/P07332" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.", "evidence": [ { "database": "UniProtKB", "id": "P07332", "url": "https://www.uniprot.org/uniprot/P07332" }, { "database": "PubMed", "id": "19382747", "url": "https://glygen.org/publication/PubMed/19382747" }, { "database": "PubMed", "id": "18775312", "url": "https://glygen.org/publication/PubMed/18775312" }, { "database": "PubMed", "id": "18046454", "url": "https://glygen.org/publication/PubMed/18046454" }, { "database": "PubMed", "id": "20111072", "url": "https://glygen.org/publication/PubMed/20111072" }, { "database": "PubMed", "id": "7687763", "url": "https://glygen.org/publication/PubMed/7687763" }, { "database": "PubMed", "id": "19001085", "url": "https://glygen.org/publication/PubMed/19001085" }, { "database": "PubMed", "id": "15485904", "url": "https://glygen.org/publication/PubMed/15485904" } ] } ], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WUD9-1", "P57760-1", "P35739-1", "F1LYY7-1", "A0A8I6GCV6-1", "Q63132-1", "Q63117-1", "Q5U2X5-1", "Q63474-1", "Q4V8A3-1", "O08680-1", "O35346-1", "P54757-1", "P54758-1", "P54759-1", "P70600-1", "Q00495-1", "Q03351-1", "Q04589-1", "P06494-1", "P09759-1", "P29321-1", "P32577-1", "Q6XUX2-1", "Q62662-1", "Q62799-1", "Q62844-1", "Q62956-1", "Q63184-1", "Q63470-1", "Q498D6-1", "Q01621-1", "Q6P6U0-1", "Q63604-1", "P09760-1", "Q01986-1", "Q62862-1", "Q63572-1", "Q07014-1", "Q4KSH7-1", "G3V9H8-1", "P15127-1", "O08775-1", "P53767-1", "Q05030-1", "P55146-1", "Q64725-1", "Q63802-1", "Q64716-1", "P09215-1", "Q62689-1", "F1LM93-1", "P36506-1", "P20786-1", "P24062-1", "Q924U5-1", "Q63272-1", "B2RYC7-1", "P41243-1", "M0RDA4-1", "Q62838-1", "Q63116-1", "A0A8I6AM23-1", "P50545-1", "P57097-1", "P97523-1", "Q91ZT1-1", "D4A7W7-1", "F1LVI0-1", "E9PSY0-1", "A0A0G2K6M9-1", "F1LSN4-1", "F1MAJ0-1", "A0A0R4J8U1-1", "A0A8I6A5T6-1", "D3ZDS3-1", "D4ADZ5-1", "F1LSG7-1", "F1LRZ0-1", "D3ZBN3-1", "F1M0N1-1", "G3V6K6-1", "D3ZD03-1", "D3ZZK3-1", "E9PT20-1", "D4A584-1", "D3ZDH4-1", "A0A8I5ZVE3-1", "A0A8I6AWX7-1", "Q4KM97-1", "Q501W1-1", "B5DFD6-1", "Q5FVG7-1", "D3ZCD0-1", "A0A8I5ZP97-1", "A0A0G2JW59-1", "B1WC09-1", "Q01134-1", "P11980-1", "G3V783-1", "D3ZJI4-1", "Q4KSH6-1", "M0R7E7-1", "Q925D6-1", "Q9UM73-1", "O15146-1", "P42679-1", "P08922-1", "P07947-1", "Q12866-1", "P00519-1", "Q07912-1", "P42684-1", "Q9UF33-1", "P10721-1", "P08069-1", "P06239-1", "P04626-1", "P51451-1", "Q06187-1", "P51813-1", "Q9UIG0-1", "P49760-1", "P49761-4", "Q9HAZ1-1", "P49759-1", "P07333-1", "Q5JZY3-1", "Q6XUX3-1", "P00533-1", "Q9Y463-1", "P29317-1", "Q9NR20-1", "Q13627-1", "P54760-1", "P41240-1", "Q16832-1", "Q15375-1", "P29323-1", "P22455-1", "P16591-1", "P29322-1", "P54756-1", "P29320-1", "Q08345-1", "Q92630-1", "P54753-1", "Q15303-1", "P21860-1", "Q14289-1", "O43781-1", "P54764-1", "P19525-1", "P21709-1", "P54762-1", "P22607-1", "P21802-1", "P52333-1", "P11362-1", "P42685-1", "P06213-1", "P14616-1", "Q05655-1", "Q08881-1", "P07332-1", "P08631-1", "P29376-1", "Q05397-1", "O60674-1", "P23458-1", "P36888-1", "P09769-1", "P06241-1", "P43405-1", "P07948-1", "P46734-1", "P45985-1", "Q02750-1", "P52564-1", "O14733-1", "Q13163-1", "Q16288-1", "P36507-1", "Q16620-1", "P08581-1", "P04629-1", "Q14680-1", "Q01974-1", "P09619-1", "P07949-1", "Q504Y2-1", "P34925-1", "P16234-1", "Q13882-1", "Q04912-1", "O43353-1", "Q06418-1", "P30530-1", "Q96KB5-1", "Q15569-1", "Q96S53-1", "Q6J9G0-1", "P42680-1", "P35916-2", "P0C1S8-1", "P17948-1", "P29597-1", "P42681-1", "P35590-1", "Q13470-1", "P33981-1", "P30291-1", "P12931-1", "P35968-1", "P43403-1", "O75716-1", "Q02763-1", "Q9H3Y6-1", "P35790-1", "P14618-1", "P24604-1", "Q9Z188-1", "P35969-1", "P52332-1", "P08923-1", "Q00342-1", "Q62120-1", "Q4JIM5-1", "P97504-1", "P42682-1", "Q60629-1", "O54967-1", "P00520-1", "P97793-1", "P16277-1", "O35491-1", "O35492-1", "O35493-1", "Q9Z277-1", "P35991-1", "P22518-1", "Q8BYG9-1", "P54754-1", "P54761-1", "Q6XUX1-1", "Q62371-1", "Q60750-1", "Q61527-1", "Q62413-1", "Q61214-1", "Q61772-1", "Q61851-1", "Q922Y0-1", "Q922K9-1", "O09127-1", "P16092-1", "Q03142-1", "P29319-1", "Q01279-1", "P70424-1", "P21803-1", "Q8CBF3-1", "P41241-1", "Q03963-1", "Q8BI55-1", "P54763-3", "P16879-1", "P09581-1", "P34152-3", "P14234-1", "P39688-1", "Q03146-1", "Q03145-1", "Q61526-1", "P70451-1", "Q5U4C9-1", "Q9QVP9-1", "Q03137-1", "Q60751-1", "Q62137-1", "P28867-1", "P25911-1", "P48025-1", "Q9WTL4-1", "P41242-1", "P05532-1", "P06240-1", "P08103-1", "P15208-1", "Q03526-1", "Q9WVS7-1", "P70236-1", "P31938-1", "P47809-1", "Q61846-1", "Q60805-1", "Q63932-1", "O09110-1", "P26618-1", "Q8CE90-1", "P16056-1", "P05622-1", "P15209-1", "Q6VNS1-1", "Q61006-1", "Q3UFB7-1", "Q5RJI4-1", "Q9JJ78-1", "P58801-1", "Q8VCT9-1", "O70146-1", "Q62190-1", "Q62270-1", "P35546-1", "P35761-1", "Q9Z138-1", "Q9R117-1", "O88697-1", "P05480-2", "Q01887-1", "Q02858-1", "Q06806-1", "Q00993-1", "Q64434-1", "Q6J9G1-1", "Q99ML2-1", "Q78DX7-1", "P55144-1", "P43404-1", "P35917-1", "P47810-1", "P35918-1", "Q04736-1", "Q66JT0-1", "O54804-1", "P52480-1", "P14680-1", "P21965-1", "P22216-1", "P32490-1", "P06784-1", "P08018-1", "P32350-1", "P32491-1", "P54199-1", "Q54G28-1", "Q54N73-1", "Q54R58-1", "P18160-1", "P18161-1", "Q54BC9-1", "Q54I36-1", "Q54QV3-1", "Q552C6-1", "Q55CL6-1", "Q75JK0-1", "Q76NV1-1", "Q23977-1", "P18475-1", "P13368-1", "Q24145-1", "Q24488-1", "Q27324-1", "P08630-1", "P00522-1", "P00528-1", "P04412-1", "Q9V422-1", "Q9V6K3-1", "Q9V9J3-1", "Q9VBW3-1", "P09208-1", "P49762-1", "P83102-1", "Q24324-1", "Q9VPC0-1", "P49657-1", "P54350-1", "P18106-4", "Q07407-1", "Q09147-1", "Q24592-1", "Q9I7F7-1", "Q9V3D5-1", "Q9VZI2-1", "Q8INJ8-1", "Q7KJ08-1", "Q9VJ04-1", "E1JHB7-1", "Q9VE06-1", "O61444-1", "O62602-1", "Q9VZA8-1", "Q7KT06-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-HSA-205328", "name": "Interaction of other tyrosine kinases with p-KIT", "equation": "", "summary": "Cytoplasmic tyrosine kinases such as CHK1 (Csk homologous kinase or MATK), FER and FES associate with p-KIT upon SCF stimulation (Price et al, 19997; Jhun et al, 1995; Craig AW, Greer PA, 2002). TEC has been demonstrated to associate with KIT constitutively and is activated by ligand stimulation (Tang et a l. 1994).", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10721-1", "O14757-1", "P07332-1", "P42680-1", "P16591-1" ], "evidence": [ { "id": "R-HSA-205328", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-205328" } ] }, { "id": "R-HSA-399928", "name": "Recruitment of Rnd1 to Plexin A", "equation": "", "summary": "Binding of Sema3A to the Neuropilin-1-Plexin-A receptor complex results in the recruitment of Rnd1 to the cytoplasmic linker region of Plexin-A. Rnd1 activates the cytoplasmic GTPase signaling domain of Plexin-A.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P63000-1", "P07332-1" ], "evidence": [ { "id": "R-HSA-399928", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399928" } ] }, { "id": "R-HSA-399930", "name": "Activation of PAK by Rac1", "equation": "", "summary": "Plexin-bound Rac1 binds to and stimulates the kinase activity of PAK. PAK dimers are arranged in head-to-tail fashion, in which the catalytic domain binds the kinase inhibitory (KI) domain and is supported by associated PAK-interacting exchange factor (PIX) dimers. Upon Rac1 binding the kinase undergoes conformational change that allows autophosphorylation. Phosphorylation of serine residues disables the KI-domain-kinase interaction and thereby reduces the affinity of PIX.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P63000-1", "P07332-1", "Q13153-1", "Q13177-1", "O75914-1" ], "evidence": [ { "id": "R-HSA-399930", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399930" } ] }, { "id": "R-HSA-399934", "name": "Phosphorylation of Plexin-A", "equation": "", "summary": "Sema3A binding to Neuropilin-1:Plexin-A complex results in conformational change of plexin-A and this conformational change permits Fes nonreceptor tyrosine kinase to bind and phosphorylate Plexin-A. The specific tyrosine residues phosphorylated in the cytoplasmic domain of plexins in response to semaphorin stimulation have not yet been identified.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-HSA-396937" ], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07332-1" ], "evidence": [ { "id": "R-HSA-399934", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399934" } ] }, { "id": "R-HSA-399935", "name": "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity", "equation": "", "summary": "Plexin-A's are GAPs for the Ras family GTPase R-Ras. On stimulation with Rnd-1, plexin-A directly and specifically down regulates R-Ras activity. R-Ras activity is critical for PI3K activation and ECM-mediated beta1 integrin activation and cell migration. Inactivation of R-Ras by Sema3A/Plexin-A1 reduces integrin-mediated adhesions. It has been suggested that the final step in the Sema3A repulsive signaling pathway is inhibition of integrin activity. Reduced integrin activity allows detachment from the substratum and subsequent cell retraction.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P63000-1", "P07332-1", "P10301-1" ], "evidence": [ { "id": "R-HSA-399935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399935" } ] }, { "id": "R-HSA-399939", "name": "Autophosphorylation of PAK", "equation": "", "summary": "PAK is autophosphorylated at several sites but S-144 flanking the kinase inhibitor region and T-423 (S-141/T-402 in PAK-gamma) within the catalytic domain are the two conserved sites that regulate the catalytic activity.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P63000-1", "P07332-1", "Q13153-1", "Q13177-1", "O75914-1" ], "evidence": [ { "id": "R-HSA-399939", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399939" } ] }, { "id": "R-HSA-399941", "name": "Rac1 binds PlexinA", "equation": "", "summary": "Active Rac1 associates directly with Plexin-A1 in the linker region separating Plexin-A1's cytoplasmic GAP domains. Rac1 association relieves an inhibitory intramolecular interaction between the two Plexin-A1 GAP domains C1 and C2.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P63000-1", "P07332-1" ], "evidence": [ { "id": "R-HSA-399941", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399941" } ] }, { "id": "R-HSA-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "equation": "", "summary": "Fes bound to Plexin-A is able to phosphorylate all five forms of CRMP, though neither specific sites nor the consequence of tyrosine phosphorylation in CRMP's have yet been investigated directly.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06241-1", "P07332-1" ], "evidence": [ { "id": "R-HSA-399947", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399947" } ] }, { "id": "R-HSA-399952", "name": "Phosphorylation of LIMK-1 by PAK", "equation": "", "summary": "LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53667-1", "P06241-1", "P63000-1", "P07332-1", "Q13153-1", "Q13177-1", "O75914-1" ], "evidence": [ { "id": "R-HSA-399952", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399952" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-396937", "participant_name": "FES [cytosol]", "crossref": [ { "id": "P07332", "database": "UniProt", "url": "" }, { "id": "2DCR", "database": "PDB", "url": "" }, { "id": "NP_001137256.1", "database": "RefSeq", "url": "" }, { "id": "XP_016877497.1", "database": "RefSeq", "url": "" }, { "id": "1WQU", "database": "PDB", "url": "" }, { "id": "NP_001137255.1", "database": "RefSeq", "url": "" }, { "id": "FES_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "HMDBP01494", "database": "HMDB Protein", "url": "" }, { "id": "XP_016877496.1", "database": "RefSeq", "url": "" }, { "id": "FES_HUMAN", "database": "ZINC - Investigational", "url": "" }, { "id": "NP_001996.1", "database": "RefSeq", "url": "" }, { "id": "XP_016877499.1", "database": "RefSeq", "url": "" }, { "id": "P07332", "database": "PRO", "url": "" }, { "id": "NP_001137257.1", "database": "RefSeq", "url": "" }, { "id": "P07332", "database": "ZINC target", "url": "" }, { "id": "3BKB", "database": "PDB", "url": "" }, { "id": "ENSG00000182511", "database": "OpenTargets", "url": "" }, { "id": "XP_016877498.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000182511-FES", "database": "HPA", "url": "" }, { "id": "4DYL", "database": "PDB", "url": "" }, { "id": "XP_005254939.1", "database": "RefSeq", "url": "" }, { "id": "ENSP00000377837", "database": "Ensembl", "url": "" }, { "id": "4E93", "database": "PDB", "url": "" }, { "id": "6JMF", "database": "PDB", "url": "" }, { "id": "XP_016877494.1", "database": "RefSeq", "url": "" }, { "id": "ENSP00000331504", "database": "Ensembl", "url": "" }, { "id": "7T1K", "database": "PDB", "url": "" }, { "id": "ENST00000394300", "database": "Ensembl", "url": "" }, { "id": "XP_016877495.1", "database": "RefSeq", "url": "" }, { "id": "ENST00000414248", "database": "Ensembl", "url": "" }, { "id": "ENST00000444422", "database": "Ensembl", "url": "" }, { "id": "ENSP00000414629", "database": "Ensembl", "url": "" }, { "id": "ENSP00000400868", "database": "Ensembl", "url": "" }, { "id": "ENSG00000182511", "database": "Ensembl", "url": "" }, { "id": "7T1L", "database": "PDB", "url": "" }, { "id": "FES_HUMAN", "database": "ZINC - FDA approved", "url": "" }, { "id": "ENST00000328850", "database": "Ensembl", "url": "" }, { "id": "3CBL", "database": "PDB", "url": "" }, { "id": "FES_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "P07332", "database": "GeneCards", "url": "" }, { "id": "XP_005254937.1", "database": "RefSeq", "url": "" }, { "id": "FES_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "3CD3", "database": "PDB", "url": "" }, { "id": "FES_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "P07332", "database": "Pharos - Targets", "url": "" }, { "id": "2023", "database": "Guide to Pharmacology - Targets", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JW59", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] } ] }, { "uniprot_ac": "A0A0G2K6M9", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] } ] }, { "uniprot_ac": "A0A0R4J8U1", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] } ] }, { "uniprot_ac": "A0A8I5ZP97", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] } ] }, { "uniprot_ac": "A0A8I5ZVE3", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] } ] }, { "uniprot_ac": "A0A8I6A5T6", "gene_name": "Mst1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] } ] }, { "uniprot_ac": "A0A8I6AM23", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] } ] }, { "uniprot_ac": "A0A8I6AWX7", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] } ] }, { "uniprot_ac": "A0A8I6GCV6", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] } ] }, { "uniprot_ac": "B1WC09", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] } ] }, { "uniprot_ac": "B2RYC7", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] } ] }, { "uniprot_ac": "B5DFD6", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] } ] }, { "uniprot_ac": "D3ZBN3", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] } ] }, { "uniprot_ac": "D3ZCD0", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] } ] }, { "uniprot_ac": "D3ZD03", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] } ] }, { "uniprot_ac": "D3ZDH4", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] } ] }, { "uniprot_ac": "D3ZDS3", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] } ] }, { "uniprot_ac": "D3ZJI4", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] } ] }, { "uniprot_ac": "D3ZZK3", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] } ] }, { "uniprot_ac": "D4A584", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] } ] }, { "uniprot_ac": "D4A7W7", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] } ] }, { "uniprot_ac": "D4ADZ5", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "E9PSY0", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] } ] }, { "uniprot_ac": "E9PT20", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] } ] }, { "uniprot_ac": "F1LM93", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] } ] }, { "uniprot_ac": "F1LRZ0", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] } ] }, { "uniprot_ac": "F1LSG7", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] } ] }, { "uniprot_ac": "F1LSN4", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] } ] }, { "uniprot_ac": "F1LVI0", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] } ] }, { "uniprot_ac": "F1LYY7", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] } ] }, { "uniprot_ac": "F1M0N1", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] } ] }, { "uniprot_ac": "F1MAJ0", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] } ] }, { "uniprot_ac": "G3V6K6", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "G3V9H8", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] } ] }, { "uniprot_ac": "M0R7E7", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] } ] }, { "uniprot_ac": "M0RDA4", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] } ] }, { "uniprot_ac": "O08680", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] } ] }, { "uniprot_ac": "O08775", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] } ] }, { "uniprot_ac": "O09110", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] } ] }, { "uniprot_ac": "O09127", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] } ] }, { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] } ] }, { "uniprot_ac": "O14757", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14757" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14757" } ] } ] }, { "uniprot_ac": "O15146", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] } ] }, { "uniprot_ac": "O35346", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] } ] }, { "uniprot_ac": "O35491", "gene_name": "Clk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] } ] }, { "uniprot_ac": "O35492", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] } ] }, { "uniprot_ac": "O35493", "gene_name": "Clk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] } ] }, { "uniprot_ac": "O54804", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] } ] }, { "uniprot_ac": "O54967", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] } ] }, { "uniprot_ac": "O60674", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "O62602", "gene_name": "lic", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] } ] }, { "uniprot_ac": "O70146", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] } ] }, { "uniprot_ac": "O75914", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75914" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75914" } ] } ] }, { "uniprot_ac": "O88697", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] } ] }, { "uniprot_ac": "P00519", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] } ] }, { "uniprot_ac": "P00520", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P00533", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P04626", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] } ] }, { "uniprot_ac": "P04629", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] } ] }, { "uniprot_ac": "P05480", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] } ] }, { "uniprot_ac": "P05532", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] } ] }, { "uniprot_ac": "P05622", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] } ] }, { "uniprot_ac": "P06239", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] } ] }, { "uniprot_ac": "P06240", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] } ] }, { "uniprot_ac": "P06241", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] } ] }, { "uniprot_ac": "P06494", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] } ] }, { "uniprot_ac": "P06784", "gene_name": "STE7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] } ] }, { "uniprot_ac": "P07332", "gene_name": "FES", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] } ] }, { "uniprot_ac": "P07333", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] } ] }, { "uniprot_ac": "P07947", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] } ] }, { "uniprot_ac": "P07948", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] } ] }, { "uniprot_ac": "P07949", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] } ] }, { "uniprot_ac": "P08018", "gene_name": "PBS2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] } ] }, { "uniprot_ac": "P08069", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] } ] }, { "uniprot_ac": "P08103", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] } ] }, { "uniprot_ac": "P08581", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] } ] }, { "uniprot_ac": "P08630", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] } ] }, { "uniprot_ac": "P08631", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] } ] }, { "uniprot_ac": "P08922", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] } ] }, { "uniprot_ac": "P08923", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] } ] }, { "uniprot_ac": "P09208", "gene_name": "InR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P09581", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09581" } ] } ] }, { "uniprot_ac": "P09619", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] } ] }, { "uniprot_ac": "P09759", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] } ] }, { "uniprot_ac": "P09760", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] } ] }, { "uniprot_ac": "P0C1S8", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] } ] }, { "uniprot_ac": "P10301", "gene_name": "RRAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P10301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10301" } ] } ] }, { "uniprot_ac": "P10721", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] } ] }, { "uniprot_ac": "P11362", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12931", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] } ] }, { "uniprot_ac": "P13368", "gene_name": "sev", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] } ] }, { "uniprot_ac": "P14234", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] } ] }, { "uniprot_ac": "P14616", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14680", "gene_name": "YAK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] } ] }, { "uniprot_ac": "P15127", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] } ] }, { "uniprot_ac": "P15208", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] } ] }, { "uniprot_ac": "P15209", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] } ] }, { "uniprot_ac": "P16056", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] } ] }, { "uniprot_ac": "P16092", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] } ] }, { "uniprot_ac": "P16234", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] } ] }, { "uniprot_ac": "P16277", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] } ] }, { "uniprot_ac": "P16591", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] } ] }, { "uniprot_ac": "P16879", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] } ] }, { "uniprot_ac": "P17948", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P18160", "gene_name": "splA", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] } ] }, { "uniprot_ac": "P18161", "gene_name": "splB", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] } ] }, { "uniprot_ac": "P18475", "gene_name": "tor", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] } ] }, { "uniprot_ac": "P20786", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] } ] }, { "uniprot_ac": "P21709", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] } ] }, { "uniprot_ac": "P21802", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] } ] }, { "uniprot_ac": "P21803", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] } ] }, { "uniprot_ac": "P21860", "gene_name": "ERBB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] } ] }, { "uniprot_ac": "P21965", "gene_name": "MCK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] } ] }, { "uniprot_ac": "P22216", "gene_name": "RAD53", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] } ] }, { "uniprot_ac": "P22455", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] } ] }, { "uniprot_ac": "P22518", "gene_name": "Clk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] } ] }, { "uniprot_ac": "P22607", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] } ] }, { "uniprot_ac": "P23458", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] } ] }, { "uniprot_ac": "P24062", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] } ] }, { "uniprot_ac": "P24604", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] } ] }, { "uniprot_ac": "P25911", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] } ] }, { "uniprot_ac": "P26618", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P29317", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] } ] }, { "uniprot_ac": "P29319", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] } ] }, { "uniprot_ac": "P29320", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] } ] }, { "uniprot_ac": "P29321", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] } ] }, { "uniprot_ac": "P29322", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] } ] }, { "uniprot_ac": "P29323", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] } ] }, { "uniprot_ac": "P29376", "gene_name": "LTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] } ] }, { "uniprot_ac": "P29597", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] } ] }, { "uniprot_ac": "P30530", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] } ] }, { "uniprot_ac": "P31938", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] } ] }, { "uniprot_ac": "P32350", "gene_name": "KNS1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] } ] }, { "uniprot_ac": "P32490", "gene_name": "MKK1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] } ] }, { "uniprot_ac": "P32491", "gene_name": "MKK2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] } ] }, { "uniprot_ac": "P32577", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] } ] }, { "uniprot_ac": "P34152", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] } ] }, { "uniprot_ac": "P34925", "gene_name": "RYK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] } ] }, { "uniprot_ac": "P35546", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] } ] }, { "uniprot_ac": "P35590", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] } ] }, { "uniprot_ac": "P35739", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] } ] }, { "uniprot_ac": "P35761", "gene_name": "Ttk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] } ] }, { "uniprot_ac": "P35790", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] } ] }, { "uniprot_ac": "P35916", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] } ] }, { "uniprot_ac": "P35917", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] } ] }, { "uniprot_ac": "P35918", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] } ] }, { "uniprot_ac": "P35968", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] } ] }, { "uniprot_ac": "P35969", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] } ] }, { "uniprot_ac": "P35991", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] } ] }, { "uniprot_ac": "P36506", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] } ] }, { "uniprot_ac": "P36888", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] } ] }, { "uniprot_ac": "P39688", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] } ] }, { "uniprot_ac": "P41240", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] } ] }, { "uniprot_ac": "P41241", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] } ] }, { "uniprot_ac": "P41242", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] } ] }, { "uniprot_ac": "P41243", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] } ] }, { "uniprot_ac": "P42679", "gene_name": "MATK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] } ] }, { "uniprot_ac": "P42680", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] } ] }, { "uniprot_ac": "P42681", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] } ] }, { "uniprot_ac": "P42682", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] } ] }, { "uniprot_ac": "P42684", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] } ] }, { "uniprot_ac": "P42685", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] } ] }, { "uniprot_ac": "P43403", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] } ] }, { "uniprot_ac": "P43404", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] } ] }, { "uniprot_ac": "P43405", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] } ] }, { "uniprot_ac": "P47809", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] } ] }, { "uniprot_ac": "P47810", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] } ] }, { "uniprot_ac": "P48025", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P50545", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] } ] }, { "uniprot_ac": "P51451", "gene_name": "BLK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] } ] }, { "uniprot_ac": "P51813", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] } ] }, { "uniprot_ac": "P52332", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] } ] }, { "uniprot_ac": "P52333", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] } ] }, { "uniprot_ac": "P53667", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53667" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53667" } ] } ] }, { "uniprot_ac": "P53767", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] } ] }, { "uniprot_ac": "P54199", "gene_name": "MPS1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] } ] }, { "uniprot_ac": "P54350", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] } ] }, { "uniprot_ac": "P54753", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] } ] }, { "uniprot_ac": "P54754", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] } ] }, { "uniprot_ac": "P54756", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] } ] }, { "uniprot_ac": "P54757", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] } ] }, { "uniprot_ac": "P54758", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] } ] }, { "uniprot_ac": "P54759", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] } ] }, { "uniprot_ac": "P54760", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] } ] }, { "uniprot_ac": "P54761", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] } ] }, { "uniprot_ac": "P54762", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] } ] }, { "uniprot_ac": "P54763", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] } ] }, { "uniprot_ac": "P54764", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] } ] }, { "uniprot_ac": "P55144", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] } ] }, { "uniprot_ac": "P55146", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] } ] }, { "uniprot_ac": "P57097", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] } ] }, { "uniprot_ac": "P57760", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] } ] }, { "uniprot_ac": "P58801", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] } ] }, { "uniprot_ac": "P63000", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63000" } ] } ] }, { "uniprot_ac": "P70236", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] } ] }, { "uniprot_ac": "P70424", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] } ] }, { "uniprot_ac": "P70451", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] } ] }, { "uniprot_ac": "P70600", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P97504", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] } ] }, { "uniprot_ac": "P97523", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] } ] }, { "uniprot_ac": "P97793", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] } ] }, { "uniprot_ac": "Q00342", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] } ] }, { "uniprot_ac": "Q00495", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] } ] }, { "uniprot_ac": "Q00993", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] } ] }, { "uniprot_ac": "Q01134", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] } ] }, { "uniprot_ac": "Q01279", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] } ] }, { "uniprot_ac": "Q01621", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] } ] }, { "uniprot_ac": "Q01887", "gene_name": "Ryk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] } ] }, { "uniprot_ac": "Q01974", "gene_name": "ROR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] } ] }, { "uniprot_ac": "Q01986", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] } ] }, { "uniprot_ac": "Q02763", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] } ] }, { "uniprot_ac": "Q02858", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] } ] }, { "uniprot_ac": "Q03137", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] } ] }, { "uniprot_ac": "Q03142", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] } ] }, { "uniprot_ac": "Q03145", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] } ] }, { "uniprot_ac": "Q03146", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] } ] }, { "uniprot_ac": "Q03351", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] } ] }, { "uniprot_ac": "Q03526", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q04589", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] } ] }, { "uniprot_ac": "Q04736", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] } ] }, { "uniprot_ac": "Q04912", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] } ] }, { "uniprot_ac": "Q05030", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] } ] }, { "uniprot_ac": "Q05397", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06187", "gene_name": "BTK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] } ] }, { "uniprot_ac": "Q06418", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] } ] }, { "uniprot_ac": "Q06806", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] } ] }, { "uniprot_ac": "Q07014", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] } ] }, { "uniprot_ac": "Q07407", "gene_name": "htl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] } ] }, { "uniprot_ac": "Q07912", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] } ] }, { "uniprot_ac": "Q08345", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] } ] }, { "uniprot_ac": "Q08881", "gene_name": "ITK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] } ] }, { "uniprot_ac": "Q09147", "gene_name": "btl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] } ] }, { "uniprot_ac": "Q12866", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] } ] }, { "uniprot_ac": "Q13153", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13153" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13153" } ] } ] }, { "uniprot_ac": "Q13163", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] } ] }, { "uniprot_ac": "Q13177", "gene_name": "PAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13177" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13177" } ] } ] }, { "uniprot_ac": "Q13470", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] } ] }, { "uniprot_ac": "Q13627", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + 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"2.7.10.2", "activity": "", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] } ] }, { "uniprot_ac": "Q14289", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] } ] }, { "uniprot_ac": "Q14680", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] } ] }, { "uniprot_ac": "Q15303", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] } ] }, { "uniprot_ac": "Q15375", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] } ] }, { "uniprot_ac": "Q15569", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] } ] }, { "uniprot_ac": "Q16288", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] } ] }, { "uniprot_ac": "Q16620", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] } ] }, { "uniprot_ac": "Q16832", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24145", "gene_name": "Shark", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q24488", "gene_name": "Ror", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] } ] }, { "uniprot_ac": "Q24592", "gene_name": "hop", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] } ] }, { "uniprot_ac": "Q27324", "gene_name": "drl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] } ] }, { "uniprot_ac": "Q3UFB7", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] } ] }, { "uniprot_ac": "Q498D6", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] } ] }, { "uniprot_ac": "Q4JIM5", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] } ] }, { "uniprot_ac": "Q4KM97", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] } ] }, { "uniprot_ac": "Q4KSH6", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { "uniprot_ac": "Q4V8A3", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] } ] }, { "uniprot_ac": "Q501W1", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + 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"https://www.uniprot.org/uniprot/Q54BC9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] } ] }, { "uniprot_ac": "Q54G28", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] } ] }, { "uniprot_ac": "Q54I36", "gene_name": "pyk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] } ] }, { "uniprot_ac": "Q54N73", "gene_name": "7tmk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] } ] }, { "uniprot_ac": "Q54QV3", "gene_name": "yakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] } ] }, { "uniprot_ac": "Q54R58", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] } ] }, { "uniprot_ac": "Q552C6", "gene_name": "zak2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] } ] }, { "uniprot_ac": "Q55CL6", "gene_name": "mekA", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] } ] }, { "uniprot_ac": "Q5FVG7", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] } ] }, { "uniprot_ac": "Q5JZY3", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] } ] }, { "uniprot_ac": "Q5RJI4", "gene_name": "Pkdcc", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] } ] }, { "uniprot_ac": "Q5U2X5", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] } ] }, { "uniprot_ac": "Q5U4C9", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] } ] }, { "uniprot_ac": "Q60629", "gene_name": "Epha5", "activity": [ { "ec_number": 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] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61006" } ] } ] }, { "uniprot_ac": "Q61214", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q61214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] } ] }, { "uniprot_ac": "Q61526", "gene_name": "Erbb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61526" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61526" } ] } ] }, { "uniprot_ac": "Q61527", "gene_name": "Erbb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61527" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61527" } ] } ] }, { "uniprot_ac": "Q61772", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", 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"https://www.uniprot.org/uniprot/Q62413" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62413" } ] } ] }, { "uniprot_ac": "Q62662", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] } ] }, { "uniprot_ac": "Q62689", "gene_name": "Jak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62689" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62689" } ] } ] }, { "uniprot_ac": "Q62799", "gene_name": "Erbb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62799" } ] } ] }, { "uniprot_ac": "Q62838", "gene_name": "Musk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] } ] }, { 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L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] } ] }, { "uniprot_ac": "Q63116", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] } ] }, { "uniprot_ac": "Q63117", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63117", "database": 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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] } ] }, { "uniprot_ac": "Q63272", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] } ] }, { "uniprot_ac": "Q63470", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", 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"Q63802", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] } ] }, { "uniprot_ac": "Q63932", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] } ] }, { "uniprot_ac": "Q64434", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] 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"https://www.uniprot.org/uniprot/Q8CBF3" } ] } ] }, { "uniprot_ac": "Q8CE90", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q8VCT9", "gene_name": "Tesk2", "activity": 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"Q99ML2", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] } ] }, { "uniprot_ac": "Q9H3Y6", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] } ] }, { "uniprot_ac": "Q9HAZ1", "gene_name": "CLK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] 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