{ "uniprot_canonical_ac": "P07306-1", "uniprot_ac": "P07306", "uniprot_id": "ASGR1_HUMAN", "mass": { "chemical_mass": 33186.0, "monoisotopic_mass": 33186.0 }, "refseq": { "ac": "NP_001184145", "name": "asialoglycoprotein receptor 1 isoform b", "summary": "This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" }, "gene_names": [ { "name": "ASGR1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07306", "id": "P07306" }, { "name": "ASGPR; ASGPR1; CLEC4H1; HL-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145", "id": "NP_001184145" }, { "name": "ASGR1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145", "id": "NP_001184145" }, { "name": "CLEC4H1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07306", "id": "P07306" } ], "protein_names": [ { "name": "Asialoglycoprotein receptor 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07306" }, { "name": "ASGP-R 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07306" }, { "name": "ASGPR 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07306" }, { "name": "C-type lectin domain family 4 member H1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07306" }, { "name": "HL-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07306" }, { "name": "Hepatic lectin H1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07306" }, { "name": "asialoglycoprotein receptor 1 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145", "id": "NP_001184145" }, { "name": "hepatic lectin H1; C-type lectin domain family 4 member H1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145", "id": "NP_001184145" } ], "function": [ { "annotation": "Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" }, { "database": "PubMed", "id": "34762653", "url": "https://glygen.org/publication/PubMed/34762653" } ] }, { "annotation": "Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306#function" } ] }, { "annotation": "Novel SARS-CoV-2 receptors: ASGR1 and KREMEN1.", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" }, { "database": "PubMed", "id": "34903854", "url": "https://glygen.org/publication/PubMed/34903854" } ] }, { "annotation": "Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Erratum:[Cell Res. 2022 Jun;32(6):600. PMID: 35365756]", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" }, { "database": "PubMed", "id": "34837059", "url": "https://glygen.org/publication/PubMed/34837059" } ] }, { "annotation": "This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" } ] }, { "annotation": "Two naturally occurring ASGPR1 splice variants are produced in human hepatocytes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" }, { "database": "PubMed", "id": "20886072", "url": "https://glygen.org/publication/PubMed/20886072" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P07306", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07306" }, { "id": "rs1238826217", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1238826217" }, { "id": "rs1238826217", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1238826217" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 115, "end_pos": 115, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "17", "chr_pos": "7176842", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D115", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1490692541", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1490692541" }, { "id": "rs1490692541", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1490692541#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 182, "end_pos": 182, "sequence_org": "C", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NYC->NYS).", "chr_id": "17", "chr_pos": "7174188", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "C182", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1257674622", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1257674622" }, { "id": "rs1257674622", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1257674622" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 220, "end_pos": 220, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGP->NGT).", "chr_id": "17", "chr_pos": "7174004", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P220", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1441819922", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1441819922" }, { "id": "rs1441819922", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1441819922" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 283, "end_pos": 283, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KAS->NAS).", "chr_id": "17", "chr_pos": "7173686", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K283", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1255064215", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1255064215" }, { "id": "rs1255064215", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1255064215" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 81, "end_pos": 81, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NFT->NFP).", "chr_id": "17", "chr_pos": "7177023", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T81", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "58.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "41.27", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "56.16", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "67.46", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "59.57", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "54.88", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "76.55", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "98.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "66.2", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "63.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000141505", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000141505" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P07306", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07306" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial 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"https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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}, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": 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"database": "BioXpress", "id": "P07306", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07306" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P07306", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07306" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07306" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P07306", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07306" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P07306", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07306" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:432", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:432", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "108360", "url": "http://www.omim.org/entry/108360", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P07306", "url": "https://www.nextprot.org/entry/NX_P07306", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "NGHQFSK", "url": "https://omabrowser.org/oma/group/NGHQFSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3991783at2759", "url": "http://www.orthodb.org/?query=3991783at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22802", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22802", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22802:SF240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22802:SF240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803:SF116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803:SF116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1DV8", "url": "https://www.rcsb.org/structure/1DV8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5JPV", "url": "https://www.rcsb.org/structure/5JPV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5JQ1", "url": "https://www.rcsb.org/structure/5JQ1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6YAU", "url": "https://www.rcsb.org/structure/6YAU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00059", "url": "http://pfam.xfam.org/family/PF00059", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03954", "url": "http://pfam.xfam.org/family/PF03954", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P07306", "url": "https://pharos.nih.gov/targets/P07306", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P07306", "url": "http://purl.obolibrary.org/obo/PR_P07306", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "I3L129", "url": "https://www.uniprot.org/uniprot/I3L129", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "I3L129-1", "url": "https://www.uniprot.org/uniprot/I3L129-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "I3L1F8", "url": "https://www.uniprot.org/uniprot/I3L1F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "I3L1F8-1", "url": "https://www.uniprot.org/uniprot/I3L1F8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "I3L2S9", "url": "https://www.uniprot.org/uniprot/I3L2S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "I3L2S9-1", "url": "https://www.uniprot.org/uniprot/I3L2S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QSZ2", "url": "https://www.uniprot.org/uniprot/J3QSZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QSZ2-1", "url": "https://www.uniprot.org/uniprot/J3QSZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EPS5", "url": "https://www.uniprot.org/uniprot/K7EPS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EPS5-1", "url": "https://www.uniprot.org/uniprot/K7EPS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07306-1", "url": "https://www.uniprot.org/uniprot/P07306-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07306-2", "url": "https://www.uniprot.org/uniprot/P07306-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL", "length": 291, "header": "sp|P07306-1|ASGR1_HUMAN Isoform 1 of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=2 CANONICAL=P07306-1" }, "isoforms": [ { "isoform_ac": "I3L129-1", "url": "", "sequence": { "sequence": "MAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFK", "length": 94, "header": "tr|I3L129-1|ASGR1_HUMAN Computationally mapped isoform of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=1 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7174395, "end_pos": 7173960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000572879.5", "url": "https://www.ensembl.org/id/ENST00000572879.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000458530.1", "url": "https://www.ensembl.org/id/ENSP00000458530.1" } ] } }, { "isoform_ac": "I3L1F8-1", "url": "", "sequence": { "sequence": "MKSLESQLEKQQKDLSEDHSSLLLHVKQF", "length": 29, "header": "tr|I3L1F8-1|ASGR1_HUMAN Computationally mapped isoform of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=8 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7176881, "end_pos": 7174426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000570576.1", "url": "https://www.ensembl.org/id/ENST00000570576.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000458803.1", "url": "https://www.ensembl.org/id/ENSP00000458803.1" } ] } }, { "isoform_ac": "I3L2S9-1", "url": "", "sequence": { "sequence": "MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLS", "length": 117, "header": "tr|I3L2S9-1|ASGR1_HUMAN Computationally mapped isoform of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=1 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7178563, "end_pos": 7176834, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000573083.1", "url": "https://www.ensembl.org/id/ENST00000573083.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000459896.1", "url": "https://www.ensembl.org/id/ENSP00000459896.1" } ] } }, { "isoform_ac": "J3QSZ2-1", "url": "", "sequence": { "sequence": "MKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL", "length": 190, "header": "tr|J3QSZ2-1|ASGR1_HUMAN Computationally mapped isoform of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=1 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7176881, "end_pos": 7173662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000380920.8", "url": "https://www.ensembl.org/id/ENST00000380920.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000370307.4", "url": "https://www.ensembl.org/id/ENSP00000370307.4" } ] } }, { "isoform_ac": "K7EPS5-1", "url": "", "sequence": { "sequence": "XRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFK", "length": 162, "header": "tr|K7EPS5-1|ASGR1_HUMAN Computationally mapped isoform of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=1 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7177046, "end_pos": 7173959, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000574330.5", "url": "https://www.ensembl.org/id/ENST00000574330.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467511.1", "url": "https://www.ensembl.org/id/ENSP00000467511.1" } ] } }, { "isoform_ac": "P07306-1", "url": "", "sequence": { "sequence": "MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL", "length": 291, "header": "sp|P07306-1|ASGR1_HUMAN Isoform 1 of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=2 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7178563, "end_pos": 7173662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000269299.8", "url": "https://www.ensembl.org/id/ENST00000269299.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000269299.3", "url": "https://www.ensembl.org/id/ENSP00000269299.3" } ] } }, { "isoform_ac": "P07306-2", "url": "", "sequence": { "sequence": "MTKEYQDLQHLDNEESDHHQLRKDSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL", "length": 252, "header": "sp|P07306-2|ASGR1_HUMAN Isoform 2 of Asialoglycoprotein receptor 1 OS=Homo sapiens OX=9606 GN=ASGR1 PE=1 SV=2 CANONICAL=P07306-1" }, "locus": { "chromosome": "17", "start_pos": 7178563, "end_pos": 7173662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000619926.4", "url": "https://www.ensembl.org/id/ENST00000619926.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000481182.1", "url": "https://www.ensembl.org/id/ENSP00000481182.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 147, "start_aa": "Asn", "end_pos": 147, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn147", "evidence": [ { "id": "P07306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07306#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 79, "start_aa": "Asn", "end_pos": 79, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn79", "evidence": [ { "id": "P07306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07306#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19159218" } ] } ], "phosphorylation": [ { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P07306", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07306" } ], "site_lbl": "Ser16" }, { "start_pos": 285, "end_pos": 285, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P07306", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07306" } ], "site_lbl": "Ser285" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.", "journal": "J. Mol. Biol.", "date": "2000", "authors": "Meier M, Bider M D, Malashkevich V N, Spiess M, Burkhard P", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" } ], "reference": [ { "type": "PubMed", "id": "10891274", "url": "https://glygen.org/publication/PubMed/10891274" } ] }, { "title": "Oligosaccharyltransferase is highly specific for the hydroxy amino acid in Asn-Xaa-Thr/Ser.", "journal": "FEBS letters", "date": "2001", "authors": "Breuer W, Klein RA, Hardt B, Bartoschek A, Bause E", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "11470266", "url": "https://glygen.org/publication/PubMed/11470266" } ] }, { "title": "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.", "journal": "Genomics", "date": "2001", "authors": "Pan H, Qin W X, Huo K K, Wan D F, Yu Y, Xu Z G, Hu Q D, Gu K T, Zhou X M, Jiang H Q, Zhang P P, Huang Y, Li Y Y, Gu J R", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" } ], "reference": [ { "type": "PubMed", "id": "11543633", "url": "https://glygen.org/publication/PubMed/11543633" } ] }, { "title": "H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Saxena A, Yik JH, Weigel PH", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "12089159", "url": "https://glygen.org/publication/PubMed/12089159" } ] }, { "title": "Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Yik JH, Saxena A, Weigel JA, Weigel PH", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "12171918", "url": "https://glygen.org/publication/PubMed/12171918" } ] }, { "title": "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.", "journal": "The Biochemical journal", "date": "2003", "authors": "Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "12678917", "url": "https://glygen.org/publication/PubMed/12678917" } ] }, { "title": "Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding.", "journal": "Glycobiology", "date": "2004", "authors": "Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "14514716", "url": "https://glygen.org/publication/PubMed/14514716" } ] }, { "title": "Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain.", "journal": "Journal of biochemistry", "date": "2003", "authors": "Lo Presti L, Cabuy E, Chiricolo M, Dall'Olio F", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "14688233", "url": "https://glygen.org/publication/PubMed/14688233" } ] }, { "title": "An evolving view of the eukaryotic oligosaccharyltransferase.", "journal": "Glycobiology", "date": "2006", "authors": "Kelleher DJ, Gilmore R", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "16317064", "url": "https://glygen.org/publication/PubMed/16317064" } ] }, { "title": "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.", "journal": "Journal of proteome research", "date": "2009", "authors": "Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306#ptm_processing" }, { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" } ], "reference": [ { "type": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "title": "Screening for OST deficiencies in unsolved CDG-I patients.", "journal": "Biochemical and biophysical research communications", "date": "2009", "authors": "Vleugels W, Schollen E, Foulquier F, Matthijs G", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "19835842", "url": "https://glygen.org/publication/PubMed/19835842" } ] }, { "title": "Uromodulin facilitates neutrophil migration across renal epithelial monolayers.", "journal": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology", "date": "2010", "authors": "Schmid M, Prajczer S, Gruber LN, Bertocchi C, Gandini R, Pfaller W, Jennings P, Joannidis M", 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PLC/PRF/5 cells by HEV through interaction with ORF2.", "journal": "J. 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Chem.", "date": "1985", "authors": "Spiess M, Schwartz A L, Lodish H F", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" } ], "reference": [ { "type": "PubMed", "id": "2982798", "url": "https://glygen.org/publication/PubMed/2982798" } ] }, { "title": "Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.", "journal": "PLoS genetics", "date": "2021", "authors": "Xie B, Shi X, Li Y, Xia B, Zhou J, Du M, Xing X, Bai L, Liu E, Alvarez F, Jin L, Deng S, Mitchell GA, Pan D, Li M, Wu J", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" } ], "reference": [ { "type": "PubMed", "id": "34762653", "url": "https://glygen.org/publication/PubMed/34762653" } ] }, { "title": "Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.", "journal": "Cell research", "date": "2022", "authors": "Gu Y, Cao J, Zhang X, Gao H, Wang Y, Wang J, He J, Jiang X, Zhang J, Shen G, Yang J, Zheng X, Hu G, Zhu Y, Du S, Zhu Y, Zhang R, Xu J, Lan F, Qu D, Xu G, Zhao Y, Gao D, Xie Y, Luo M, Lu Z", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" } ], "reference": [ { "type": "PubMed", "id": "34837059", "url": "https://glygen.org/publication/PubMed/34837059" } ] }, { "title": "Novel SARS-CoV-2 receptors: ASGR1 and KREMEN1.", "journal": "Cell research", "date": "2022", "authors": "Hoffmann M, Pohlmann S", "evidence": [ { "database": "RefSeq", "id": "NP_001184145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184145" } ], "reference": [ { "type": "PubMed", "id": "34903854", "url": "https://glygen.org/publication/PubMed/34903854" } ] }, { "title": "An internal signal sequence: the asialoglycoprotein receptor membrane anchor.", "journal": "Cell", "date": "1986", "authors": "Spiess M, Lodish H F", "evidence": [ { "database": "UniProtKB", "id": "P07306", "url": "https://www.uniprot.org/uniprot/P07306" } ], "reference": [ { "type": "PubMed", "id": "3753585", "url": "https://glygen.org/publication/PubMed/3753585" } ] }, { "title": "The relationship between the N-acetylgalactosamine content and the blood group Sda activity of Tamm and Horsfall urinary glycoprotein.", "journal": "Biochemical and biophysical research communications", "date": "1980", "authors": "Soh CP, Morgan WT, Watkins WM, Donald AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "6156677", "url": "https://glygen.org/publication/PubMed/6156677" } ] }, { "title": "Precipitin reaction between Sda-active human Tamm-Horsfall glycoprotein and anti-Sda-serum.", "journal": "Vox sanguinis", "date": "1982", "authors": "Serafini-Cessi F, Conte R", "evidence": [ { "database": "Reactome", "id": "R-HSA-446203", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-446203" } ], "reference": [ { "type": "PubMed", "id": "7072193", "url": "https://glygen.org/publication/PubMed/7072193" } ] }, { "title": "Fatty acylation of the rat and human asialoglycoprotein receptors. 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