{ "uniprot_canonical_ac": "P07204-1", "uniprot_ac": "P07204", "uniprot_id": "TRBM_HUMAN", "mass": { "chemical_mass": 60329.0, "monoisotopic_mass": 60329.0 }, "refseq": { "ac": "NP_000352", "name": "thrombomodulin precursor", "summary": "The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" }, "gene_names": [ { "name": "THBD", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07204", "id": "P07204" }, { "name": "AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM; TM", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352", "id": "NP_000352" }, { "name": "THBD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352", "id": "NP_000352" }, { "name": "THRM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07204", "id": "P07204" } ], "protein_names": [ { "name": "Thrombomodulin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07204" }, { "name": "Fetomodulin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07204" }, { "name": "TM", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07204" }, { "name": "fetomodulin; CD141 antigen", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352", "id": "NP_000352" }, { "name": "thrombomodulin precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352", "id": "NP_000352" } ], "function": [ { "annotation": "A missense mutation in lectin domain of thrombomodulin causing functional deficiency.", "evidence": [ { "database": "RefSeq", "id": "NP_000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" }, { "database": "PubMed", "id": "35921923", "url": "https://glygen.org/publication/PubMed/35921923" } ] }, { "annotation": "Novel nucleotide variations in the thrombomodulin (THBD) gene involved in coagulation pathways can increase the risk of recurrent pregnancy loss (RPL).", "evidence": [ { "database": "RefSeq", "id": "NP_000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" }, { "database": "PubMed", "id": "37979949", "url": "https://glygen.org/publication/PubMed/37979949" } ] }, { "annotation": "On the relevance of thrombomodulin variants in atypical hemolytic uremic syndrome.", "evidence": [ { "database": "RefSeq", "id": "NP_000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" }, { "database": "PubMed", "id": "37567446", "url": "https://glygen.org/publication/PubMed/37567446" } ] }, { "annotation": "The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" } ] }, { "annotation": "The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.", "evidence": [ { "database": "RefSeq", "id": "NP_000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" }, { "database": "PubMed", "id": "38081783", "url": "https://glygen.org/publication/PubMed/38081783" } ] }, { "annotation": "Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.", "evidence": [ { "database": "UniProtKB", "id": "P07204", "url": "https://www.uniprot.org/uniprot/P07204#function" } ] }, { "annotation": "Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000352" }, { "database": "PubMed", "id": "38057335", "url": "https://glygen.org/publication/PubMed/38057335" } ] } ], "disease": [ { "disease_id": "DOID:0111908", "recommended_name": { "id": "DOID:0111908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111908", "name": "thrombophilia due to thrombomodulin defect", "description": "A thrombophilia characterized by increased risk of developing arterial but not venous thrombosis that has_material_basis_in mutation in the THBD gene on chromosome 20p11.21." }, "synonyms": [ { "id": "DOID:0111908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111908", "name": "THPH12", "description": "" }, { "id": "DOID:0111908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111908", "name": "THBD-related bleeding disorder", 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"https://monarchinitiative.org/disease/MONDO:0013775", "name": "THBD-related coagulopathy", "description": "" }, { "id": "MONDO:0013775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013775", "name": "thrombomodulin-related coagulopathy", "description": "" }, { "id": "MONDO:0013775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013775", "name": "thrombophilia 12 due to thrombomodulin defect", "description": "" }, { "id": "MONDO:0013775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013775", "name": "THPH12", "description": "" }, { "id": "MONDO:0013775", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013775", "name": "thrombophilia due to thrombomodulin defect", "description": "" }, { "id": "MIM:614486", "resource": "MIM", "url": "https://www.omim.org/entry/614486", "name": "Thrombophilia due to thrombomodulin defect", "description": "Thrombophilia due to thrombomodulin 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"start_aa": "Asn", "end_pos": 116, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn116", "evidence": [ { "id": "P07204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07204#ptm_processing" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "site_category": "automatic_literature_mining", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 287, "start_aa": "Ser", "end_pos": 287, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser287", "evidence": [ { "id": "12458951", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/12458951" }, { "id": "12458951", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12458951" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 382, "start_aa": "Asn", "end_pos": 382, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn382", "evidence": [ { "id": "P07204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07204#ptm_processing" }, { "id": "1DQB", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1DQB" }, { "id": "1314561", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/1314561" }, { "id": "1314561", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1314561" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 409, "start_aa": "Asn", "end_pos": 409, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn409", "evidence": [ { "id": "P07204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07204#ptm_processing" }, { "id": "1DQB", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1DQB" }, { "id": "1314561", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/1314561" }, { "id": "1314561", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1314561" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 47, "start_aa": "Asn", "end_pos": 47, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn47", "evidence": [ { "id": "P07204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07204#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (chondroitin sulfate) serine", "start_pos": 490, "start_aa": "Ser", "end_pos": 490, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser490", "evidence": [ { "id": "P07204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07204#ptm_processing" }, { "id": "8216207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8216207" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (chondroitin sulfate) serine", "start_pos": 492, "start_aa": "Ser", "end_pos": 492, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser492", "evidence": [ { "id": "P07204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07204#ptm_processing" }, { "id": "8216207", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8216207" } ] }, { "glytoucan_ac": "G77199IL", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "591", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/591" }, { "id": "10026155", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10026155" } ] }, { "glytoucan_ac": "G84168AG", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "591", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/591" }, { "id": "10026155", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10026155" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Novel proteoglycan linkage tetrasaccharides of human urinary soluble thrombomodulin, SO4-3GlcAbeta1-3Galbeta1-3(+/-Siaalpha2-6)Galbeta1-4Xyl.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Wakabayashi H, Natsuka S, Mega T, Otsuki N, Isaji M, Naotsuka M, Koyama S, Kanamori T, Sakai K, Hase S", "evidence": [ { "database": "GlyConnect", "id": "591", "url": "https://glyconnect.expasy.org/browser/proteins/591" } ], "reference": [ { "type": "PubMed", "id": "10026155", "url": "https://glygen.org/publication/PubMed/10026155" } ] }, { "title": "Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Yegneswaran S, Smirnov MD, Safa O, Esmon NL, Esmon CT, Johnson AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "10026158", "url": "https://glygen.org/publication/PubMed/10026158" } ] }, { "title": "The biology of the 17-1A antigen (Ep-CAM).", "journal": "Journal of molecular medicine (Berlin, Germany)", "date": "1999", "authors": "Balzar M, Winter MJ, de Boer CJ, Litvinov SV", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "10606205", "url": "https://glygen.org/publication/PubMed/10606205" } ] }, { "title": "The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells.", "journal": "Seminars in immunology", "date": "2000", "authors": "Tangye SG, Phillips JH, Lanier LL", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "10764623", "url": "https://glygen.org/publication/PubMed/10764623" } ] }, { "title": "The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2000", "authors": "Kurosawa S, Esmon CT, Stearns-Kurosawa DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "11035113", "url": "https://glygen.org/publication/PubMed/11035113" } ] }, { "title": "Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding.", "journal": "Cellular microbiology", "date": "1999", "authors": "Popp A, Dehio C, Grunert F, Meyer TF, Gray-Owen SD", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "11207550", "url": "https://glygen.org/publication/PubMed/11207550" } ] }, { "title": "Endothelial cell protein C receptor plays an important role in protein C activation in vivo.", "journal": "Blood", "date": "2001", "authors": "Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "11238108", "url": "https://glygen.org/publication/PubMed/11238108" } ] }, { "title": "Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease.", "journal": "Circulation", "date": "2001", "authors": "Wu K K, Aleksic N, Ahn C, Boerwinkle E, Folsom A R, Juneja H,", "evidence": [ { "database": "UniProtKB", "id": "P07204", "url": "https://www.uniprot.org/uniprot/P07204" } ], "reference": [ { "type": "PubMed", "id": "11245641", "url": "https://glygen.org/publication/PubMed/11245641" } ] }, { "title": "Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor.", "journal": "Journal of cell science", "date": "2001", "authors": "Shi X, Niimi S, Ohtani T, Machida S", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "11256994", "url": "https://glygen.org/publication/PubMed/11256994" } ] }, { "title": "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2001", "authors": "Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "11564780", "url": "https://glygen.org/publication/PubMed/11564780" } ] }, { "title": "The potential of plasma thrombomodulin as a biomarker of portal vein tumor thrombus in hepatocellular carcinoma.", "journal": "Journal of cancer research and clinical oncology", "date": "2001", "authors": "Zhou J, Tang ZY, Fan J, Wu ZQ, Ji Y, Ye SL", "evidence": [ { "database": "GlyGen", "id": "A0120", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "11570577", "url": "https://glygen.org/publication/PubMed/11570577" } ] }, { "title": "Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy.", "journal": "Biochemical and biophysical research communications", "date": "2002", "authors": "McDonald KJ, Cameron AJ, Allen JM, Jardine AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "11779189", "url": "https://glygen.org/publication/PubMed/11779189" } ] }, { "title": "JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.", "journal": "Nature immunology", "date": "2002", "authors": "Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "11812992", "url": "https://glygen.org/publication/PubMed/11812992" } ] }, { "title": "Activation of endothelial cell protease activated receptor 1 by the protein C pathway.", "journal": "Science (New York, N.Y.)", "date": "2002", "authors": "Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "12052963", "url": "https://glygen.org/publication/PubMed/12052963" } ] }, { "title": "JAM2 interacts with alpha4beta1. Facilitation by JAM3.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "12070135", "url": "https://glygen.org/publication/PubMed/12070135" } ] }, { "title": "Mutations in the thrombomodulin gene are rare in patients with severe thrombophilia.", "journal": "British journal of haematology", "date": "2002", "authors": "Faioni EM, Franchi F, Castaman G, Biguzzi E, Rodeghiero F", "evidence": [ { "database": "UniProtKB", "id": "P07204", "url": "https://www.uniprot.org/uniprot/P07204" } ], "reference": [ { "type": "PubMed", "id": "12139752", "url": "https://glygen.org/publication/PubMed/12139752" } ] }, { "title": "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.", "journal": "The Journal of experimental medicine", "date": "2002", "authors": "Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, Chavakis T", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "12208882", "url": "https://glygen.org/publication/PubMed/12208882" } ] }, { "title": "Structural analysis of a glycoprotein by liquid chromatography-mass spectrometry and liquid chromatography with tandem mass spectrometry. Application to recombinant human thrombomodulin.", "journal": "Journal of chromatography. A", "date": "2002", "authors": "Itoh S, Kawasaki N, Ohta M, Hayakawa T", "evidence": [ { "database": "Automatic Literature Mining", "id": "12458951", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/12458951" } ], "reference": [ { "type": "PubMed", "id": "12458951", "url": "https://glygen.org/publication/PubMed/12458951" } ] }, { "title": "Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.", "journal": "Nature medicine", "date": "2003", "authors": "Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "12469115", "url": "https://glygen.org/publication/PubMed/12469115" } ] }, { "title": "MIF signal transduction initiated by binding to CD74.", "journal": "The Journal of experimental medicine", "date": "2003", "authors": "Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "12782713", "url": "https://glygen.org/publication/PubMed/12782713" } ] }, { "title": "Heparin-induced substrate behavior of antithrombin Cambridge II.", "journal": "Blood", "date": "2003", "authors": "Mushunje A, Zhou A, Carrell RW, Huntington JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "12907439", "url": "https://glygen.org/publication/PubMed/12907439" } ] }, { "title": "Recombinant human thrombomodulin. Regulation of cofactor activity and anticoagulant function by a glycosaminoglycan side chain.", "journal": "The Biochemical journal", "date": "1992", "authors": "Parkinson JF, Vlahos CJ, Yan SC, Bang NU", "evidence": [ { "database": "Automatic Literature Mining", "id": "1314561", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/1314561" } ], "reference": [ { "type": "PubMed", "id": "1314561", "url": "https://glygen.org/publication/PubMed/1314561" } ] }, { "title": "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design.", "journal": "Current protein & peptide science", "date": "2003", "authors": "Wilkins AL, Yang W, Yang JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "14529530", "url": "https://glygen.org/publication/PubMed/14529530" } ] }, { "title": "Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2004", "authors": "da Costa Martins P, van den Berk N, Ulfman LH, Koenderman L, Hordijk PL, Zwaginga JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "14615387", "url": "https://glygen.org/publication/PubMed/14615387" } ] }, { "title": "The factor V activation paradox.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "14982929", "url": "https://glygen.org/publication/PubMed/14982929" } ] }, { "title": "Human lectin-like oxidized low-density 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