{ "uniprot_canonical_ac": "P07098-1", "uniprot_ac": "P07098", "uniprot_id": "LIPF_HUMAN", "mass": { "chemical_mass": 45238.0, "monoisotopic_mass": 45238.0 }, "refseq": { "ac": "NP_001185757", "name": "gastric triacylglycerol lipase isoform 3 precursor", "summary": "This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" }, "gene_names": [ { "name": "LIPF", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07098", "id": "P07098" }, { "name": "GL; HGL; HLAL", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757", "id": "NP_001185757" }, { "name": "LIPF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757", "id": "NP_001185757" } ], "protein_names": [ { "name": "Gastric triacylglycerol lipase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07098" }, { "name": "3.1.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07098" }, { "name": "GL", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07098" }, { "name": "Gastric lipase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07098" }, { "name": "gastric triacylglycerol lipase isoform 3 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757", "id": "NP_001185757" }, { "name": "gastric triacylglycerol lipase; gastric lipase; lipase, gastric", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757", "id": "NP_001185757" } ], "function": [ { "annotation": "Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091).", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098#function" }, { "database": "PubMed", "id": "10358049", "url": "https://glygen.org/publication/PubMed/10358049" }, { "database": "PubMed", "id": "2243091", "url": "https://glygen.org/publication/PubMed/2243091" } ] }, { "annotation": "In patients with intrahepatic cholestasis of pregnancy, there was no elevation in LIPF mRNA in maternal circulation compared with controls.", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" }, { "database": "PubMed", "id": "25059952", "url": "https://glygen.org/publication/PubMed/25059952" } ] }, { "annotation": "Insights into the domain movements", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" }, { "database": "PubMed", "id": "20965171", "url": "https://glygen.org/publication/PubMed/20965171" } ] }, { "annotation": "LIPFDGKA might serve as a potential possible biomarkers for diagnosis of gastric cancer, and their downregulation may bring new perspective into the investigation of gastric cancer prognosis", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" }, { "database": "PubMed", "id": "27498782", "url": "https://glygen.org/publication/PubMed/27498782" } ] }, { "annotation": "Recombinant human gastric lipase (hGL) was transiently expressed in Nicotiana benthamiana leaves using the CPMV-HT expression system.", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" }, { "database": "PubMed", "id": "21945702", "url": "https://glygen.org/publication/PubMed/21945702" } ] }, { "annotation": "Site-directed mutagenesis the role of three key residues (K4, E225, R229) involved in salt bridges stabilizing the lid domain that controls the access to the active site and is part of the interfacial recognition site. Their substitution has an impact on the pH-dependent activity of rHGL and its relative activities on medium and long chain triglycerides.", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" }, { "database": "PubMed", "id": "28694218", "url": "https://glygen.org/publication/PubMed/28694218" } ] }, { "annotation": "This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1426047711", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1426047711" }, { "id": "rs1426047711", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1426047711" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 101, "end_pos": 101, "sequence_org": "S", "sequence_mut": "C", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNS->NNC).", "chr_id": "10", "chr_pos": "88668635", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S101", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P07098", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07098" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 159, "end_pos": 159, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KKT->NKT).", "chr_id": "10", "chr_pos": "88669891", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "K159", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P07098", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07098" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 237, "end_pos": 237, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "F", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NFF->NFS).", "chr_id": "10", "chr_pos": "88673628", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "F237", "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs913624021", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs913624021" }, { "id": "rs913624021", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs913624021" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 273, "end_pos": 273, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTS->NTN).", "chr_id": "10", "chr_pos": "88675587", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S273", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P07098", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07098" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 293, "end_pos": 293, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "H", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (HWT->NWT).", "chr_id": "10", "chr_pos": "88675646", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "H293", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": 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passed 1 out of 1 filters: n-glyco-sequon-gain (NWI->NWT).", "chr_id": "10", "chr_pos": "88668615", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I94", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs771681636", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771681636" }, { "id": "rs771681636", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771681636" }, { "id": "rs771681636", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs771681636" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 98, "end_pos": 98, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLP->NLS).", "chr_id": "10", "chr_pos": "88668626", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P98", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": 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"namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "41.27", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "99.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "80.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "23.82", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "63.98", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "55.82", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "25.52", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333" } ] }, { "tissue": { "name": "Prostate 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hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P07098", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07098" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P07098", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07098" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07098" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "common_name": "Human" } ], "gene": [ { "name": "LIPF", "url": "https://www.uniprot.org/uniprot/P07098", "locus": { "chromosome": "10", "start_pos": 88678814, "end_pos": 88664441, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000182333", "url": "https://www.ensembl.org/id/ENSG00000182333" } ] } } ], "crossref": [ { "id": "ENSG00000182333", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000182333", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P07098", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07098", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "CHEMBL1796", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1796", "database": "ChEMBL", "categories": 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"categories": [ "Protein Classification" ] }, { "id": "hsa:8513", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8513", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "601980", "url": "http://www.omim.org/entry/601980", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P07098", "url": "https://www.nextprot.org/entry/NX_P07098", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "WSRRNLY", "url": "https://omabrowser.org/oma/group/WSRRNLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5474043at2759", "url": "http://www.orthodb.org/?query=5474043at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11005:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11005:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1HLG", "url": "https://www.rcsb.org/structure/1HLG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00561", "url": "http://pfam.xfam.org/family/PF00561", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P07098", "url": "https://pharos.nih.gov/targets/P07098", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P07098", "url": "http://purl.obolibrary.org/obo/PR_P07098", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12044", "url": "https://www.rhea-db.org/rhea/12044", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39931", "url": "https://www.rhea-db.org/rhea/39931", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40047", "url": "https://www.rhea-db.org/rhea/40047", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07098-1", "url": "https://www.uniprot.org/uniprot/P07098-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07098-2", "url": "https://www.uniprot.org/uniprot/P07098-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07098-3", "url": "https://www.uniprot.org/uniprot/P07098-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07098-4", "url": "https://www.uniprot.org/uniprot/P07098-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK", "length": 398, "header": "sp|P07098-1|LIPF_HUMAN Isoform 1 of Gastric triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPF PE=1 SV=1 CANONICAL=P07098-1" }, "isoforms": [ { "isoform_ac": "P07098-1", "url": "", "sequence": { "sequence": "MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK", "length": 398, "header": "sp|P07098-1|LIPF_HUMAN Isoform 1 of Gastric triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPF PE=1 SV=1 CANONICAL=P07098-1" }, "locus": { "chromosome": "10", "start_pos": 88678678, "end_pos": 88667298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000238983.9", "url": "https://www.ensembl.org/id/ENST00000238983.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000238983.5", "url": "https://www.ensembl.org/id/ENSP00000238983.5" } ] } }, { "isoform_ac": "P07098-2", "url": "", "sequence": { "sequence": "MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTDAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK", "length": 365, "header": "sp|P07098-2|LIPF_HUMAN Isoform 2 of Gastric triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPF PE=1 SV=1 CANONICAL=P07098-1" }, "locus": { "chromosome": "10", "start_pos": 88678678, "end_pos": 88667298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000608620.5", "url": "https://www.ensembl.org/id/ENST00000608620.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000477140.1", "url": "https://www.ensembl.org/id/ENSP00000477140.1" } ] } }, { "isoform_ac": "P07098-3", "url": "", "sequence": { "sequence": "MFSNANSRSKMWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK", "length": 408, "header": "sp|P07098-3|LIPF_HUMAN Isoform 3 of Gastric triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPF PE=1 SV=1 CANONICAL=P07098-1" }, "locus": { "chromosome": "10", "start_pos": 88678678, "end_pos": 88665541, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394375.7", "url": "https://www.ensembl.org/id/ENST00000394375.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000377900.3", "url": "https://www.ensembl.org/id/ENSP00000377900.3" } ] } }, { "isoform_ac": "P07098-4", "url": "", "sequence": { "sequence": "MFSNANSRSKMWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTDAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK", "length": 375, "header": "sp|P07098-4|LIPF_HUMAN Isoform 4 of Gastric triacylglycerol lipase OS=Homo sapiens OX=9606 GN=LIPF PE=1 SV=1 CANONICAL=P07098-1" }, "locus": { "chromosome": "10", "start_pos": 88678678, "end_pos": 88665541, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000355843.2", "url": "https://www.ensembl.org/id/ENST00000355843.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000348101.3", "url": "https://www.ensembl.org/id/ENSP00000348101.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 271, "start_aa": "Asn", "end_pos": 271, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn271", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098#ptm_processing" }, { "id": "10358049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10358049" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 327, "start_aa": "Asn", "end_pos": 327, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn327", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098#ptm_processing" }, { "id": "10358049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10358049" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 34, "start_aa": "Asn", "end_pos": 34, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn34", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098#ptm_processing" }, { "id": "10358049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10358049" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 99, "start_aa": "Asn", "end_pos": 99, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn99", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098#ptm_processing" }, { "id": "10358049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10358049" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Roussel A, Canaan S, Egloff MP, Riviere M, Dupuis L, Verger R, Cambillau C", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098#ptm_processing" }, { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" }, { "database": "Reactome", "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456" } ], "reference": [ { "type": "PubMed", "id": "10358049", "url": "https://glygen.org/publication/PubMed/10358049" } ] }, { "title": "The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals.", "journal": "Gastroenterology", "date": "2000", "authors": "Carriere F, Renou C, Lopez V, De Caro J, Ferrato F, Lengsfeld H, De Caro A, Laugier R, Verger R", "evidence": [ { "database": "Reactome", "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456" } ], "reference": [ { "type": "PubMed", "id": "11040182", "url": "https://glygen.org/publication/PubMed/11040182" } ] }, { "title": "Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Giller T, Buchwald P, Blum-Kaelin D, Hunziker W", "evidence": [ { "database": "Reactome", "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456" } ], "reference": [ { "type": "PubMed", "id": "1379598", "url": "https://glygen.org/publication/PubMed/1379598" } ] }, { "title": "Molecular dynamics simulations of human and dog gastric lipases: insights into domain movements.", "journal": "FEBS letters", "date": "2010", "authors": "Selvan A, Seniya C, Chandrasekaran SN, Siddharth N, Anishetty S, Pennathur G", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" } ], "reference": [ { "type": "PubMed", "id": "20965171", "url": "https://glygen.org/publication/PubMed/20965171" } ] }, { "title": "Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system.", "journal": "Protein expression and purification", "date": "2012", "authors": "Vardakou M, Sainsbury F, Rigby N, Mulholland F, Lomonossoff GP", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" } ], "reference": [ { "type": "PubMed", "id": "21945702", "url": "https://glygen.org/publication/PubMed/21945702" } ] }, { "title": "Stereoselectivity of lipases. II. Stereoselective hydrolysis of triglycerides by gastric and pancreatic lipases.", "journal": "The Journal of biological chemistry", "date": "1990-11-25", "authors": "Rogalska E, Ransac S, Verger R", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "reference": [ { "type": "PubMed", "id": "2243091", "url": "https://glygen.org/publication/PubMed/2243091" } ] }, { "title": "The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase.", "journal": "The Journal of clinical investigation", "date": "1990", "authors": "Bernback S, Blackberg L, Hernell O", "evidence": [ { "database": "Reactome", "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456" } ], "reference": [ { "type": "PubMed", "id": "2318975", "url": "https://glygen.org/publication/PubMed/2318975" } ] }, { "title": "Intrahepatic Cholestasis of Pregnancy: mRNAs for LIPF and ELOVL4 Genes Are Not Detectable in Circulating Maternal Plasma.", "journal": "Fetal diagnosis and therapy", "date": "2015", "authors": "Zucchini C, Montesanto I, Falcone V, Azzaroli F, Pittalis MC, Farina A", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" } ], "reference": [ { "type": "PubMed", "id": "25059952", "url": "https://glygen.org/publication/PubMed/25059952" } ] }, { "title": "Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer.", "journal": "Oncology reports", "date": "2016", "authors": "Kong Y, Zheng Y, Jia Y, Li P, Wang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" } ], "reference": [ { "type": "PubMed", "id": "27498782", "url": "https://glygen.org/publication/PubMed/27498782" } ] }, { "title": "Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity.", "journal": "Eur. J. Biochem.", "date": "1989", "authors": "Bernback S, Blackberg L", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "reference": [ { "type": "PubMed", "id": "2753032", "url": "https://glygen.org/publication/PubMed/2753032" } ] }, { "title": "Constitutive expression of human gastric lipase in Pichia pastoris and site-directed mutagenesis of key lid-stabilizing residues.", "journal": "Biochimica et biophysica acta. Molecular and cell biology of lipids", "date": "2017", "authors": "Sams L, Amara S, Chakroun A, Coudre S, Paume J, Giallo J, Carriere F", "evidence": [ { "database": "RefSeq", "id": "NP_001185757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185757" } ], "reference": [ { "type": "PubMed", "id": "28694218", "url": "https://glygen.org/publication/PubMed/28694218" } ] }, { "title": "Molecular cloning of a human gastric lipase and expression of the enzyme in yeast.", "journal": "Biochim. Biophys. Acta", "date": "1987", "authors": "Bodmer M W, Angal S, Yarranton G T, Harris T J, Lyons A, King D J, Pieroni G, Riviere C, Verger R, Lowe P A", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "reference": [ { "type": "PubMed", "id": "3304425", "url": "https://glygen.org/publication/PubMed/3304425" } ] }, { "title": "Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters, glycerides and phospholipids.", "journal": "Biochimica et biophysica acta", "date": "1980", "authors": "Lombardo D, Fauvel J, Guy O", "evidence": [ { "database": "Reactome", "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456" } ], "reference": [ { "type": "PubMed", "id": "7350912", "url": "https://glygen.org/publication/PubMed/7350912" } ] }, { "title": "Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters.", "journal": "Biochimica et biophysica acta", "date": "1980", "authors": "Lombardo D, Guy O", "evidence": [ { "database": "Reactome", "id": "R-HSA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456" } ], "reference": [ { "type": "PubMed", "id": "7350913", "url": "https://glygen.org/publication/PubMed/7350913" } ] } ], "pathway": [ { "id": "hsa:8513", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8513", "resource": "KEGG Pathway" }, { "id": "R-HSA-192456", "name": "Digestion of dietary lipid", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-192456", "resource": "Reactome", "description": "Digestion of dietary lipid" } ], "orthologs": [ { "uniprot_canonical_ac": "P04634-1", "protein_name": "Gastric triacylglycerol lipase", "gene_name": "Lipf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLLLITSVISTFGGAHGLFGKLGPGNPEANMNISQMITYWGYPCQEYEVVTEDGYILGVYRIPHGKNNSENIGKRPVVYLQHGLIASATNWIANLPNNSLAFMLADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATINFIVQKTGQEKIHYVGHSQGTTIGFIAFSTNPTLAKKIKTFYALAPVATVKYTQSPLKKISFIPTFLFKLMFGKKMFLPHTYFDDFLGTEVCSREVLDLLCSNTLFIFCGFDKKNLNVSRFDVYLGHNPAGTSVQDFLHWAQLVRSGKFQAFNWGSPSQNMLHYNQKTPPEYDVSAMTVPVAVWNGGNDILADPQDVAMLLPKLSNLLFHKEILAYNHLDFIWAMDAPQEVYNEMISMMAED", "length": 395 }, "evidence": [ { "id": "45934462", "url": "http://www.informatics.jax.org/homology/45934462", "database": "MGI" }, { "id": "P07098", "url": "https://omabrowser.org/oma/group/P07098/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CPP7-1", "protein_name": "Gastric triacylglycerol lipase", "gene_name": "Lipf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "triglyceride metabolic process", "id": "GO:0006641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006641", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" }, { "name": "malate metabolic process", "id": "GO:0006108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006108", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" }, { "name": "triglyceride lipase activity", "id": "GO:0004806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004806", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" }, { "name": "malate dehydrogenase activity", "id": "GO:0016615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016615", "evidence": [ { "database": "UniProtKB", "id": "P07098", "url": "https://www.uniprot.org/uniprot/P07098" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12044", "name": "", "equation": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "Q9QZH8-1", "Q06000-1", "P04634-1", "P54318-1", "Q8VBX1-1", "P07867-1", "P15304-1", "P27657-1", "P0C548-1", "P54316-1", "P0C1S9-1", "O54728-1", "P08910-1", "P22760-1", "P19835-1", "P54315-1", "Q9Y5X9-1", "P54317-1", "Q17RR3-1", "P07098-1", "P16233-1", "Q05469-1", "P06858-1", "P11150-1", "Q9NST1-1", "Q96AD5-1", "P41247-1", "Q6P1J6-1", "Q8NCG7-1", "Q7Z6Z6-1", "Q99PG0-1", "Q9QXM0-1", "Q64285-1", "P54310-1", "P27656-1", "P17892-1", "Q9WVG5-1", "Q9CPP7-1", "P11152-1", "Q6P8U6-1", "Q91WW7-1", "Q8BJ56-1", "Q91WC9-1", "Q32LZ8-1", "Q3TTY0-1", "P25641-1", "P54857-1", "P40308-1", "P40471-1", "Q12043-1", "P36165-1", "P38139-1", "Q06522-1", "P47145-1", "Q9VMM8-1" ], "evidence": [ { "id": "12044", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12044" } ] }, { "id": "39931", "name": "", "equation": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04634-1", "P07098-1", "Q9CPP7-1" ], "evidence": [ { "id": "39931", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39931" } ] }, { "id": "40047", "name": "", "equation": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04634-1", "P07098-1", "Q9CPP7-1" ], "evidence": [ { "id": "40047", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40047" } ] }, { "id": "R-HSA-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "equation": "", "summary": "Lipases are enzymes that hydrolyse dietary lipids such as fats, oils and triglycerides. The majority of human lipases are secreted by the pancreas and function mainly in the digestive system. Humans not only digest fat with pancreatic lipases but also with gastric lipase (LIPF) (Roussel et al. 1999). The pancreatic lipase-related protein 3 (PNLIPRP3) is another candidate lipase included here.", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07098-1", "Q17RR3-1" ], "evidence": [ { "id": "R-HSA-8979996", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8979996" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "P04634", "gene_name": "Lipf", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P04634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04634" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P04634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04634" } ] } ] }, { "uniprot_ac": "P06858", "gene_name": "LPL", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "P06858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06858" } ] } ] }, { "uniprot_ac": "P07098", "gene_name": "LIPF", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07098" } ] } ] }, { "uniprot_ac": "P07867", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] } ] }, { "uniprot_ac": "P07882", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] } ] }, { "uniprot_ac": "P08910", "gene_name": "ABHD2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] } ] }, { "uniprot_ac": "P0C1S9", "gene_name": "Daglb", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] }, { "ec_number": "3.1.1.116", "activity": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] }, { "ec_number": "3.1.1.116", "activity": "", "evidence": [ { "id": "P0C1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S9" } ] } ] }, { "uniprot_ac": "P0C548", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] } ] }, { "uniprot_ac": "P11150", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] } ] }, { "uniprot_ac": "P11152", "gene_name": "Lpl", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "P11152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11152" } ] } ] }, { "uniprot_ac": "P15304", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] } ] }, { "uniprot_ac": "P16233", "gene_name": "PNLIP", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P16233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16233" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P16233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16233" } ] } ] }, { "uniprot_ac": "P17892", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] } ] }, { "uniprot_ac": "P19835", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] } ] }, { "uniprot_ac": "P22760", "gene_name": "AADAC", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P22760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22760" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P22760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22760" } ] } ] }, { "uniprot_ac": "P25641", "gene_name": "ATG15", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P25641", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25641" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P25641", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25641" } ] } ] }, { "uniprot_ac": "P27656", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] } ] }, { "uniprot_ac": "P27657", "gene_name": "Pnlip", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27657" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27657" } ] } ] }, { "uniprot_ac": "P36165", "gene_name": "TGL4", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] } ] }, { "uniprot_ac": "P38139", "gene_name": "LDH1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P38139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38139" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P38139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38139" } ] } ] }, { "uniprot_ac": "P40308", "gene_name": "TGL3", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P40308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40308" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P40308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40308" } ] } ] }, { "uniprot_ac": "P40471", "gene_name": "AYR1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] }, { "ec_number": "1.1.1.101", "activity": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+).", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] }, { "ec_number": "1.1.1.101", "activity": "", "evidence": [ { "id": "P40471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40471" } ] } ] }, { "uniprot_ac": "P41247", "gene_name": "PNPLA4", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] } ] }, { "uniprot_ac": "P47145", "gene_name": "LIH1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P47145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47145" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P47145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47145" } ] } ] }, { "uniprot_ac": "P54310", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] } ] }, { "uniprot_ac": "P54315", "gene_name": "PNLIPRP1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54315" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54315" } ] } ] }, { "uniprot_ac": "P54316", "gene_name": "Pnliprp1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54316" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54316" } ] } ] }, { "uniprot_ac": "P54317", "gene_name": "PNLIPRP2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] } ] }, { "uniprot_ac": "P54318", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] } ] }, { "uniprot_ac": "P54857", "gene_name": "TGL2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54857" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54857" } ] } ] }, { "uniprot_ac": "Q05469", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] } ] }, { "uniprot_ac": "Q06000", "gene_name": "Lpl", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] }, { "ec_number": "3.1.1.34", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] }, { "ec_number": "3.1.1.34", "activity": "", "evidence": [ { "id": "Q06000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06000" } ] } ] }, { "uniprot_ac": "Q06522", "gene_name": "", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q06522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06522" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q06522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06522" } ] } ] }, { "uniprot_ac": "Q12043", "gene_name": "TGL5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q12043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12043" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q12043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12043" } ] } ] }, { "uniprot_ac": "Q17RR3", "gene_name": "PNLIPRP3", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q17RR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q17RR3" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q17RR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q17RR3" } ] } ] }, { "uniprot_ac": "Q32LZ8", "gene_name": "Pnpla5", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q32LZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32LZ8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q32LZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32LZ8" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q64285", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": 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1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q6P8U6", "gene_name": "Pnlip", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P8U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P8U6" } ] }, { "ec_number": "3.1.1.3", "activity": "", 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"cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 34, 99, 271, 327 ], "o_linked_sites": [], "snv_sites": [ 36, 94, 98, 99, 101, 159, 237, 273, 293, 329, 362, 389 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 271, "end_pos": 273 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 99, "end_pos": 101 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", 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