{ "uniprot_canonical_ac": "P06746-1", "uniprot_ac": "P06746", "uniprot_id": "DPOLB_HUMAN", "mass": { "chemical_mass": 38178.0, "monoisotopic_mass": 38178.0 }, "refseq": { "ac": "NP_002681", "name": "DNA polymerase beta", "summary": "The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" }, "gene_names": [ { "name": "POLB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P06746", "id": "P06746" }, { "name": "POLB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681", "id": "NP_002681" } ], "protein_names": [ { "name": "DNA polymerase beta", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P06746" }, { "name": "2.7.7.7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06746" }, { "name": "4.2.99.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06746" }, { "name": "4.2.99.18", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06746" }, { "name": "5'-dRP lyase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06746" }, { "name": "5'-deoxyribose-phosphate lyase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06746" }, { "name": "AP lyase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06746" }, { "name": "DNA polymerase beta subunit; polymerase (DNA directed), beta; DNA pol beta; polymerase (DNA) beta; AP lyase; 5'-dRP lyase; 5'-deoxyribose-phosphate lyase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681", "id": "NP_002681" }, { "name": "DNA polymerase beta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681", "id": "NP_002681" } ], "function": [ { "annotation": "Coordination between human DNA polymerase beta and apurinic/apyrimidinic endonuclease 1 in the course of DNA repair.", "evidence": [ { "database": "RefSeq", "id": "NP_002681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" }, { "database": "PubMed", "id": "37806619", "url": "https://glygen.org/publication/PubMed/37806619" } ] }, { "annotation": "DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" }, { "database": "PubMed", "id": "38245510", "url": "https://glygen.org/publication/PubMed/38245510" } ] }, { "annotation": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.", "evidence": [ { "database": "UniProtKB", "id": "E5RIJ0", "url": "https://www.uniprot.org/uniprot/E5RIJ0#function" }, { "database": "UniProtKB", "id": "RU366014", "url": "https://www.uniprot.org/uniprot/RU366014#function" }, { "database": "UniProtKB", "id": "H0YBJ0", "url": "https://www.uniprot.org/uniprot/H0YBJ0#function" }, { "database": "UniProtKB", "id": "H0YBX1", "url": "https://www.uniprot.org/uniprot/H0YBX1#function" } ] }, { "annotation": "Repair polymerase that plays a key role in base-excision repair (PubMed:9207062, PubMed:9572863, PubMed:10556592). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:9572863, PubMed:9556598, PubMed:9614142, PubMed:10556592, PubMed:17526740). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142).", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746#function" }, { "database": "PubMed", "id": "9207062", "url": "https://glygen.org/publication/PubMed/9207062" }, { "database": "PubMed", "id": "21362556", "url": "https://glygen.org/publication/PubMed/21362556" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" }, { "database": "PubMed", "id": "11805079", "url": "https://glygen.org/publication/PubMed/11805079" }, { "database": "PubMed", "id": "10556592", "url": "https://glygen.org/publication/PubMed/10556592" }, { "database": "PubMed", "id": "17526740", "url": "https://glygen.org/publication/PubMed/17526740" }, { "database": "PubMed", "id": "9614142", "url": "https://glygen.org/publication/PubMed/9614142" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "annotation": "Targeting DNA polymerase beta elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia.", "evidence": [ { "database": "RefSeq", "id": "NP_002681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" }, { "database": "PubMed", "id": "37095208", "url": "https://glygen.org/publication/PubMed/37095208" } ] }, { "annotation": "The Activity of Natural Polymorphic Variants of Human DNA Polymerase beta Having an Amino Acid Substitution in the Transferase Domain. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" }, { "database": "PubMed", "id": "37174699", "url": "https://glygen.org/publication/PubMed/37174699" } ] }, { "annotation": "The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase beta toward Various Base Excision Repair Intermediates. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" }, { "database": "PubMed", "id": "37298543", "url": "https://glygen.org/publication/PubMed/37298543" } ] }, { "annotation": "The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_002681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002681" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P06746", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P06746" } ], "glycoeffect": [], "start_pos": 83, "end_pos": 83, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "8", "chr_pos": "42349076", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R83", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 152, "end_pos": 152, "sequence_org": "R", "sequence_mut": "C", "comment": "Severely decreased function in base-excision repair. Severely decreased DNA-directed DNA polymerase activity. No effect on 5'-dRP lyase activity. No effect on DNA binding. No effect on structure shown by circular dichroism. No effect on interaction with APEX1, FEN1 and PCNA.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "26760506", "url": "https://glygen.org/publication/PubMed/26760506" } ] }, { "start_pos": 152, "end_pos": 152, "sequence_org": "R", "sequence_mut": "K", "comment": "Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-83.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16600869", "url": "https://glygen.org/publication/PubMed/16600869" } ] }, { "start_pos": 25, "end_pos": 25, "sequence_org": "F", "sequence_mut": "W", "comment": "No effect on 5'-dRP lyase activity. Decreased ssDNA binding.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 285, "end_pos": 285, "sequence_org": "H", "sequence_mut": "D", "comment": "Affects DNA-directed DNA polymerase activity; contrary to wild-type enzyme, the mutant efficiently extends mispaired termini in gapped DNA. No effect on secondary structure shown by circular dichroism.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "18616290", "url": "https://glygen.org/publication/PubMed/18616290" } ] }, { "start_pos": 288, "end_pos": 288, "sequence_org": "E", "sequence_mut": "K", "comment": "Changed DNA-directed DNA polymerase activity; in complex with the DNA template and the incoming dNTP, it assumes a close conformation faster than wild-type POLB and exhibits a slower rate of nucleotide release. Results in decreased fidelity on one-base-gapped DNA and increased mutation frequency at A-T base pairs. No effect on secondary structure shown by circular dichroism. No effect on thermal stability.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "22650412", "url": "https://glygen.org/publication/PubMed/22650412" }, { "database": "PubMed", "id": "28945359", "url": "https://glygen.org/publication/PubMed/28945359" } ] }, { "start_pos": 34, "end_pos": 34, "sequence_org": "H", "sequence_mut": "G", "comment": "Decreased 5'-dRP lyase activity. Decreased ssDNA binding.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 35, "end_pos": 35, "sequence_org": "K", "sequence_mut": "A", "comment": "Decreased 5'-dRP lyase activity. Decreased ssDNA binding. Loss of 5'-dRP lyase activity; when associated with A-68 and A-72. Decreased ssDNA binding; when associated with A-68 and A-72. No effect on structure shown by circular dichroism.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 35, "end_pos": 35, "sequence_org": "K", "sequence_mut": "Q", "comment": "Reduces 5'-dRP lyase activity slightly.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" } ] }, { "start_pos": 35, "end_pos": 35, "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16172026", "url": "https://glygen.org/publication/PubMed/16172026" } ] }, { "start_pos": 39, "end_pos": 39, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16172026", "url": "https://glygen.org/publication/PubMed/16172026" } ] }, { "start_pos": 39, "end_pos": 39, "sequence_org": "Y", "sequence_mut": "Q", "comment": "Abolishes DNA polymerase and 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" } ] }, { "start_pos": 41, "end_pos": 41, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes ubiquitination; when associated with R-61 and R-81.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "19713937", "url": "https://glygen.org/publication/PubMed/19713937" } ] }, { "start_pos": 60, "end_pos": 60, "sequence_org": "K", "sequence_mut": "A", "comment": "Decreased 5'-dRP lyase activity. Decreased ssDNA binding.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 61, "end_pos": 61, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes ubiquitination; when associated with R-41 and R-81.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "19713937", "url": "https://glygen.org/publication/PubMed/19713937" } ] }, { "start_pos": 68, "end_pos": 68, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on 5'-dRP lyase activity. Decreased ssDNA binding. Loss of 5'-dRP lyase activity; when associated with A-35 and A-72. Decreased ssDNA binding; when associated with A-35 and A-72. No effect on structure shown by circular dichroism.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16172026", "url": "https://glygen.org/publication/PubMed/16172026" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 68, "end_pos": 68, "sequence_org": "K", "sequence_mut": "Q", "comment": "Slightly reduces 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" }, { "database": "PubMed", "id": "16172026", "url": "https://glygen.org/publication/PubMed/16172026" } ] }, { "start_pos": 68, "end_pos": 68, "sequence_org": "K", "sequence_mut": "R", "comment": "Slightly reduces 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" }, { "database": "PubMed", "id": "16172026", "url": "https://glygen.org/publication/PubMed/16172026" } ] }, { "start_pos": 71, "end_pos": 71, "sequence_org": "E", "sequence_mut": "Q", "comment": "No effect on 5'-dRP lyase activity. No effect on structure shown by circular dichroism. No effect on ssDNA binding.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 72, "end_pos": 72, "sequence_org": "K", "sequence_mut": "A", "comment": "Severely reduced 5'-dRP lyase activity. Does not affect ssDNA binding. Loss of 5'-dRP lyase activity; when associated with A-35 and A-68. Decreased ssDNA binding; when associated with A-35 and A-68. No effect on structure shown by circular dichroism.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16172026", "url": "https://glygen.org/publication/PubMed/16172026" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 72, "end_pos": 72, "sequence_org": "K", "sequence_mut": "Q", "comment": "Abolishes 5'-dRP lyase activity. No effect on DNA polymerase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" } ] }, { "start_pos": 72, "end_pos": 72, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes 5'-dRP lyase activity. No effect on DNA polymerase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" } ] }, { "start_pos": 75, "end_pos": 75, "sequence_org": "E", "sequence_mut": "A", "comment": "Slightly decreased 5'-dRP lyase activity. Decreased ssDNA binding. No effect on structure shown by circular dichroism.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 81, "end_pos": 81, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes ubiquitination; when associated with R-41 and R-61.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "19713937", "url": "https://glygen.org/publication/PubMed/19713937" } ] }, { "start_pos": 83, "end_pos": 83, "sequence_org": "R", "sequence_mut": "K", "comment": "Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-152.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16600869", "url": "https://glygen.org/publication/PubMed/16600869" } ] }, { "start_pos": 84, "end_pos": 84, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 84, "end_pos": 84, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on structure shown by circular dichroism. No effect on ssDNA binding.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "start_pos": 84, "end_pos": 84, "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on 5'-dRP lyase activity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" }, { "database": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "82.03", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "92.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "86.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "70.84", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "85.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "88.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "84.56", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.59", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "88.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "84.58", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "88.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000070501", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000070501" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P06746", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06746" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P06746", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06746" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", 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"https://www.uniprot.org/uniprot/E7EW18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PIC6", "url": "https://www.uniprot.org/uniprot/E9PIC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PIC6-1", "url": "https://www.uniprot.org/uniprot/E9PIC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAV8", "url": "https://www.uniprot.org/uniprot/H0YAV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAV8-1", "url": "https://www.uniprot.org/uniprot/H0YAV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YB29", "url": "https://www.uniprot.org/uniprot/H0YB29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YB29-1", "url": "https://www.uniprot.org/uniprot/H0YB29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBJ0", "url": "https://www.uniprot.org/uniprot/H0YBJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBJ0-1", "url": "https://www.uniprot.org/uniprot/H0YBJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBX1", "url": "https://www.uniprot.org/uniprot/H0YBX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBX1-1", "url": "https://www.uniprot.org/uniprot/H0YBX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06746-1", "url": "https://www.uniprot.org/uniprot/P06746-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE", "length": 335, "header": "sp|P06746-1|DPOLB_HUMAN Isoform 1 of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3 CANONICAL=P06746-1" }, "isoforms": [ { "isoform_ac": "E5RG65-1", "url": "", "sequence": { "sequence": "MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYSLE", "length": 42, "header": "tr|E5RG65-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42349022, "end_pos": 42338625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000519771.5", "url": "https://www.ensembl.org/id/ENST00000519771.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000427799.1", "url": "https://www.ensembl.org/id/ENSP00000427799.1" } ] } }, { "isoform_ac": "E5RHZ4-1", "url": "", "sequence": { "sequence": "MRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE", "length": 54, "header": "tr|E5RHZ4-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42371654, "end_pos": 42369919, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000521492.1", "url": "https://www.ensembl.org/id/ENST00000521492.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000430831.1", "url": "https://www.ensembl.org/id/ENSP00000430831.1" } ] } }, { "isoform_ac": "E5RIJ0-1", "url": "", "sequence": { "sequence": "MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRDSAVYINTPE", "length": 193, "header": "tr|E5RIJ0-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42361124, "end_pos": 42338625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522610.5", "url": "https://www.ensembl.org/id/ENST00000522610.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000429436.1", "url": "https://www.ensembl.org/id/ENSP00000429436.1" } ] } }, { "isoform_ac": "E5RJ55-1", "url": "", "sequence": { "sequence": "MLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSEST", "length": 51, "header": "tr|E5RJ55-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42361359, "end_pos": 42357209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000520008.5", "url": "https://www.ensembl.org/id/ENST00000520008.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000430610.1", "url": "https://www.ensembl.org/id/ENSP00000430610.1" } ] } }, { "isoform_ac": "E7EW18-1", "url": "", "sequence": { "sequence": "MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEGSQLDSCPVKGHLNGTESLLDLIWDVMTILKLKNADLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKN", "length": 280, "header": "tr|E7EW18-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42369297, "end_pos": 42338625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000518925.5", "url": "https://www.ensembl.org/id/ENST00000518925.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000430784.1", "url": "https://www.ensembl.org/id/ENSP00000430784.1" } ] } }, { "isoform_ac": "E9PIC6-1", "url": "", "sequence": { "sequence": "MTILKLKNADLRKNEDKLNHHQRIGLKYFGDFEKRIPR", "length": 38, "header": "tr|E9PIC6-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42357202, "end_pos": 42354494, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000532157.5", "url": "https://www.ensembl.org/id/ENST00000532157.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000432084.1", "url": "https://www.ensembl.org/id/ENSP00000432084.1" } ] } }, { "isoform_ac": "H0YAV8-1", "url": "", "sequence": { "sequence": "XESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMELQENPCQWIVKKTSLITSSGNTGNPRTGANEACILPGRHNPIGVLIYFLTFAM", "length": 106, "header": "tr|H0YAV8-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42371725, "end_pos": 42361298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000517393.1", "url": "https://www.ensembl.org/id/ENST00000517393.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000428144.1", "url": "https://www.ensembl.org/id/ENSP00000428144.1" } ] } }, { "isoform_ac": "H0YB29-1", "url": "", "sequence": { "sequence": "ASVIAKYPHKIKSGAEAKKLSICCKEVCR", "length": 29, "header": "tr|H0YB29-1|H0YB29_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=4 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42352545, "end_pos": 42344960, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000524208.5", "url": "https://www.ensembl.org/id/ENST00000524208.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428578.1", "url": "https://www.ensembl.org/id/ENSP00000428578.1" } ] } }, { "isoform_ac": "H0YBJ0-1", "url": "", "sequence": { "sequence": "XEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE", "length": 237, "header": "tr|H0YBJ0-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42371656, "end_pos": 42349039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000521290.5", "url": "https://www.ensembl.org/id/ENST00000521290.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000429597.1", "url": "https://www.ensembl.org/id/ENSP00000429597.1" } ] } }, { "isoform_ac": "H0YBX1-1", "url": "", "sequence": { "sequence": "XGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTVLQATREDLMHNMLLGPQLKAIKELQENPCQWIVKKTSLITSSGNTGNPRTGANEACILPGRHNPIGVLIYFLTFAM", "length": 239, "header": "tr|H0YBX1-1|DPOLB_HUMAN Computationally mapped isoform of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=1 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42371725, "end_pos": 42357174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000518579.5", "url": "https://www.ensembl.org/id/ENST00000518579.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000430478.1", "url": "https://www.ensembl.org/id/ENSP00000430478.1" } ] } }, { "isoform_ac": "P06746-1", "url": "", "sequence": { "sequence": "MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE", "length": 335, "header": "sp|P06746-1|DPOLB_HUMAN Isoform 1 of DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3 CANONICAL=P06746-1" }, "locus": { "chromosome": "8", "start_pos": 42371654, "end_pos": 42338625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000265421.9", "url": "https://www.ensembl.org/id/ENST00000265421.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000265421.4", "url": "https://www.ensembl.org/id/ENSP00000265421.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P06746", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06746" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "phosphorylation": [ { "start_pos": 44, "end_pos": 44, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06746", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06746" }, { "database": "PubMed", "id": "2040602", "url": "https://glygen.org/publication/PubMed/2040602" } ], "site_lbl": "Ser44" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06746", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06746" }, { "database": "PubMed", "id": "2040602", "url": "https://glygen.org/publication/PubMed/2040602" } ], "site_lbl": "Ser55" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Ame JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Hoger T, Menissier-de Murcia J, de Murcia G", "evidence": [ { "database": "Reactome", "id": "R-HSA-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110362" } ], "reference": [ { "type": "PubMed", "id": "10364231", "url": "https://glygen.org/publication/PubMed/10364231" } ] }, { "title": "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases.", "journal": "Genomics", "date": "1999", "authors": "Baker RT, Wang XW, Woollatt E, White JA, Sutherland GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "10444327", "url": "https://glygen.org/publication/PubMed/10444327" } ] }, { "title": "Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts.", "journal": "Biochemistry", "date": "1999", "authors": "Dianov GL, Jensen BR, Kenny MK, Bohr VA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "10460157", "url": "https://glygen.org/publication/PubMed/10460157" } ] }, { "title": "Functional mutation of DNA polymerase beta found in human gastric cancer--inability of the base excision repair in vitro.", "journal": "Mutation research", "date": "1999-10-22", "authors": "Iwanaga A, Ouchida M, Miyazaki K, Hori K, Mukai T", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "10556592", "url": "https://glygen.org/publication/PubMed/10556592" } ] }, { "title": "Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Matsumoto Y, Kim K, Hurwitz J, Gary R, Levin DS, Tomkinson AE, Park MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "10559261", "url": "https://glygen.org/publication/PubMed/10559261" } ] }, { "title": "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes.", "journal": "Protein Expr. Purif.", "date": "2000", "authors": "Patterson T A, Little W, Cheng X, Widen S G, Kumar A, Beard W A, Wilson S H", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "10648175", "url": "https://glygen.org/publication/PubMed/10648175" } ] }, { "title": "Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Tom S, Henricksen LA, Bambara RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "10744741", "url": "https://glygen.org/publication/PubMed/10744741" } ] }, { "title": "Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.", "journal": "Current biology : CB", "date": "2000", "authors": "Levin DS, McKenna AE, Motycka TA, Matsumoto Y, Tomkinson AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "10959839", "url": "https://glygen.org/publication/PubMed/10959839" } ] }, { "title": "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Kato M, Miyazawa K, Kitamura N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "10982817", "url": "https://glygen.org/publication/PubMed/10982817" } ] }, { "title": "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.", "journal": "Cell", "date": "2001", "authors": "Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5649702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649702" } ], "reference": [ { "type": "PubMed", "id": "11163244", "url": "https://glygen.org/publication/PubMed/11163244" } ] }, { "title": "Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA.", "journal": "The EMBO journal", "date": "2001", "authors": "Podlutsky AJ, Dianova II, Podust VN, Bohr VA, Dianov GL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "11250913", "url": "https://glygen.org/publication/PubMed/11250913" } ] }, { "title": "Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Lavrik OI, Prasad R, Sobol RW, Horton JK, Ackerman EJ, Wilson SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110362" } ], "reference": [ { "type": "PubMed", "id": "11340072", "url": "https://glygen.org/publication/PubMed/11340072" } ] }, { "title": "DNA polymerase beta -mediated long patch base excision repair. 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Evidence of alternative splicing in gene expression.", "journal": "Nucleic Acids Res.", "date": "1994", "authors": "Chyan Y J, Ackerman S, Shepherd N S, McBride O W, Widen S G, Wilson S H, Wood T G", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "7914364", "url": "https://glygen.org/publication/PubMed/7914364" } ] }, { "title": "Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Matsumoto Y, Kim K, Bogenhagen DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-110373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110373" } ], "reference": [ { "type": "PubMed", "id": "7915006", "url": "https://glygen.org/publication/PubMed/7915006" } ] }, { "title": "Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage.", "journal": "Biochemistry", "date": "1994", "authors": "Satoh MS, Poirier GG, Lindahl T", "evidence": [ { "database": "Reactome", "id": "R-HSA-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110362" } ], "reference": [ { "type": "PubMed", "id": "8003475", "url": "https://glygen.org/publication/PubMed/8003475" } ] }, { "title": "Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Prigent C, Satoh MS, Daly G, Barnes DE, Lindahl T", "evidence": [ { "database": "Reactome", "id": "R-HSA-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110362" } ], "reference": [ { "type": "PubMed", "id": "8264597", "url": "https://glygen.org/publication/PubMed/8264597" } ] }, { "title": "Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Prasad R, Singhal RK, Srivastava DK, Molina JT, Tomkinson AE, Wilson SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110362" } ], "reference": [ { "type": "PubMed", "id": "8663274", "url": "https://glygen.org/publication/PubMed/8663274" } ] }, { "title": "A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.", "journal": "Biochemistry", "date": "1996", "authors": "Pelletier H, Sawaya M R, Wolfle W, Wilson S H, Kraut J", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "8841119", "url": "https://glygen.org/publication/PubMed/8841119" } ] }, { "title": "Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.", "journal": "Biochemistry", "date": "1996", "authors": "Pelletier H, Sawaya M R", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "8841120", "url": "https://glygen.org/publication/PubMed/8841120" } ] }, { "title": "Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.", "journal": "The EMBO journal", "date": "1996", "authors": "Kubota Y, Nash RA, Klungland A, Schar P, Barnes DE, Lindahl T", "evidence": [ { "database": "Reactome", "id": "R-HSA-110381", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110381" } ], "reference": [ { "type": "PubMed", "id": "8978692", "url": "https://glygen.org/publication/PubMed/8978692" } ] }, { "title": "Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Bennett RA, Wilson DM 3rd, Wong D, Demple B", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "Reactome", "id": "R-HSA-73930", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-73930" } ], "reference": [ { "type": "PubMed", "id": "9207062", "url": "https://glygen.org/publication/PubMed/9207062" } ] }, { "title": "Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).", "journal": "The EMBO journal", "date": "1997", "authors": "Klungland A, Lindahl T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "9214649", "url": "https://glygen.org/publication/PubMed/9214649" } ] }, { "title": "Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.", "journal": "Biochemistry", "date": "1997", "authors": "Sawaya M R, Prasad R, Wilson S H, Kraut J, Pelletier H", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "9287163", "url": "https://glygen.org/publication/PubMed/9287163" } ] }, { "title": "Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities.", "journal": "The Journal of biological chemistry", "date": "1998-05-01", "authors": "Prasad R, Beard W A, Chyan J Y, Maciejewski M W, Mullen G P, Wilson S H", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "9556598", "url": "https://glygen.org/publication/PubMed/9556598" } ] }, { "title": "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups.", "journal": "Biochemistry", "date": "1998", "authors": "Matsumoto Y, Kim K, Katz DS, Feng JA", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "9572863", "url": "https://glygen.org/publication/PubMed/9572863" } ] }, { "title": "Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism.", "journal": "The Journal of biological chemistry", "date": "1998-06-12", "authors": "Prasad R, Beard W A, Strauss P R, Wilson S H", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "reference": [ { "type": "PubMed", "id": "9614142", "url": "https://glygen.org/publication/PubMed/9614142" } ] }, { "title": "DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories.", "journal": "The EMBO journal", "date": "1998", "authors": "Montecucco A, Rossi R, Levin DS, Gary R, Park MS, Motycka TA, Ciarrocchi G, Villa A, Biamonti G, Tomkinson AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "9649448", "url": "https://glygen.org/publication/PubMed/9649448" } ] }, { "title": "Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Dimitriadis EK, Prasad R, Vaske MK, Chen L, Tomkinson AE, Lewis MS, Wilson SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110362" } ], "reference": [ { "type": "PubMed", "id": "9685411", "url": "https://glygen.org/publication/PubMed/9685411" } ] }, { "title": "Mammalian base excision repair by DNA polymerases delta and epsilon.", "journal": "Oncogene", "date": "1998", "authors": "Stucki M, Pascucci B, Parlanti E, Fortini P, Wilson SH, Hubscher U, Dogliotti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5651801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651801" } ], "reference": [ { "type": "PubMed", "id": "9780000", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0003906", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "lyase activity", "id": "GO:0016829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016829", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "base-excision repair, gap-filling", "id": "GO:0006287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006287", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "response to gamma radiation", "id": "GO:0010332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010332", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "response to ethanol", "id": "GO:0045471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045471", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "neuron apoptotic process", "id": "GO:0051402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051402", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "base-excision repair", "id": "GO:0006284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006284", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "double-strand break repair via nonhomologous end joining", "id": "GO:0006303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006303", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:0008630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008630", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "spleen development", "id": "GO:0048536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048536", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "somatic hypermutation of immunoglobulin genes", "id": "GO:0016446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016446", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "response to hyperoxia", "id": "GO:0055093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055093", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "homeostasis of number of cells", "id": "GO:0048872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048872", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "salivary gland morphogenesis", "id": "GO:0007435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007435", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "pyrimidine dimer repair", "id": "GO:0006290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006290", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "lymph node development", "id": "GO:0048535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048535", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" }, { "name": "immunoglobulin heavy chain V-D-J recombination", "id": "GO:0071707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071707", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "16600869", "url": "https://glygen.org/publication/PubMed/16600869" } ] }, { "annotation": "Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.", "evidence": [ { "database": "UniProtKB", "id": "P06746", "url": "https://www.uniprot.org/uniprot/P06746" }, { "database": "PubMed", "id": "19713937", "url": "https://glygen.org/publication/PubMed/19713937" }, { "database": "PubMed", "id": "21362556", "url": "https://glygen.org/publication/PubMed/21362556" } ] } ], "interactions": [], "reactions": [ { "id": "22508", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q673L6-1", "Q5RKI3-1", "O54747-1", "O89042-1", "P06766-1", "Q9QYV8-1", "D3Z8X4-1", "E9PT58-1", "F1M8G6-1", "F7F6Z7-1", "Q07864-1", "P28340-1", "P06746-1", "Q9UGP5-1", "P54098-1", "Q9NP87-1", "P09884-1", "Q7Z5Q5-1", "O75417-1", "O00370-1", "Q9WJR5-1", "Q9UBT6-1", "O60673-1", "Q9UNA4-1", "Q9Y253-1", "P63135-1", "P10266-1", "P63132-1", "P63133-1", "P63136-1", "Q9UQG0-1", "Q9QC07-1", "P63128-1", "Q9BXR3-1", "P04053-1", "O14746-1", "P10400-1", "P11369-1", "P52431-1", "Q7TQ07-1", "Q9JIW4-1", "P54099-1", "Q8K409-1", "P33609-1", "Q9WVF7-1", "Q9QXE2-1", "Q8CGS6-1", "Q61493-1", "O70372-1", "P09838-2", "Q6R3M4-1", "Q9JJN0-1", "Q9QUG2-1", "P13382-1", "P14284-1", "P15436-1", "P15801-1", "P21951-1", "P25384-1", "P25615-1", "P46957-1", "Q04049-1", "Q06163-1", "A0A0B7P3V8-1", "O13527-1", "O13535-1", "P0C2I2-1", "P0C2I3-1", "P0C2I5-1", "P0C2I6-1", "P0C2I9-1", "P0C2J0-1", "P0C2J1-1", "P0C2J3-1", "P0C2J7-1", "P0CX63-1", "P0CX64-1", "Q99231-1", "P39985-1", "P47024-1", "P47098-1", "P47100-1", "Q12472-1", "Q03434-1", "Q03494-1", "Q03612-1", "Q03619-1", "Q03855-1", "Q04214-1", "Q04670-1", "Q04711-1", "Q07791-1", "Q07793-1", "Q12088-1", "Q12112-1", "Q12113-1", "Q12141-1", "Q12193-1", "Q12269-1", "Q12273-1", "Q12316-1", "Q12414-1", "Q12490-1", "Q12491-1", "Q12501-1", "Q7LHG5-1", "Q92393-1", "Q99315-1", "Q99337-1", "Q55AZ3-1", "Q1ZXF2-1", "Q54B44-1", "Q54N97-1", "Q54RD4-1", "Q54SV8-1", "Q9GSR1-1", "Q9VHV1-1", "Q9VNX1-1", "Q9VCN1-1", "P26019-1", "P54358-1", "Q27607-1", "O18475-1" ], "evidence": [ { "id": "22508", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22508" } ] }, { "id": "66592", "name": "", "equation": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZVH2-1", "D3ZKJ8-1", "D4A4E8-1", "O70249-1", "P62909-1", "P06766-1", "Q969S2-1", "O15527-1", "P23396-1", "P78549-1", "Q8TAT5-1", "Q13686-1", "Q96FI4-1", "P06746-1", "P0CB42-1", "P62908-1", "O08760-1", "O35980-1", "Q8K203-1", "Q8K4Q6-1", "Q6R2P8-1", "Q8K409-1", "P31378-1", "P53397-1", "Q08214-1", "Q54CZ3-1", "Q1ZXF2-1", "Q86K43-1", "Q9V3I8-1", "Q9VIH0-1" ], "evidence": [ { "id": "66592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66592" } ] }, { "id": "76255", "name": "", "equation": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "P06746-1", "Q8K409-1", "Q1ZXF2-1" ], "evidence": [ { "id": "76255", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76255" } ] }, { "id": "R-HSA-110360", "name": "Recruitment of POLB to the AP site", "equation": "", "summary": "APEX1 (APE1) bound to the apurinic/apyrimidinic site (AP site) in the DNA recruits DNA polymerase beta (POLB) into a ternary complex (Bennett et al. 1997).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27695-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-110360", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110360" } ] }, { "id": "R-HSA-110364", "name": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1", "equation": "", "summary": "PCNA-dependent long-patch base excision repair (BER) occurs during the S phase of the cell cycle when PCNA and associated DNA polymerases are available. PCNA is part of a large replicative complex that contains DNA polymerase delta or DNA polymerase epsilon, along with RPA and RFC complexes. When POLB (DNA polymerase beta) is unable to excise the oxidatively damaged AP residue (5'ddRP) at the APEX1-generated single strand break (SSB), PCNA and FEN1 are recruited to APEX1, where PCNA interacts with both APEX1 (Dianova et al. 2001) and FEN1 (Tom et al. 2000, Shibata and Nakamura 2002). PCNA-bound DNA polymerase delta complex (POLD) or DNA polymerase epsilon complex (POLE) displaces DNA polymerase beta (POLB) from the SSB (Klungland and Lindahl 1997).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-HSA-53845" ], "enzyme_list": [ "P28340-1", "Q07864-1", "P27695-1", "P39748-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-110364", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110364" } ] }, { "id": "R-HSA-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "equation": "", "summary": "After incision of the DNA strand 5' to the apurinic/apyrimidinic (AP) site by APEX1 (APE1), POLB (DNA polymerase beta) excises the 5'-terminal abasic deoxyribose phosphate (5'-dRP), thus removing the AP site (Bennet et al. 1997).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27695-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-110375", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110375" } ] }, { "id": "R-HSA-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "equation": "", "summary": "After abasic (AP) residue (5'dRP) is excised by POLB, which is accompanied by dissociation of APEX1 from the DNA, POLB recruits XRCC1:LIG3 complex, consisting of DNA repair protein XRCC1 and DNA ligase 3, to the DNA containing a single nucleotide gap (Nazarkina et al. 2007). The N-terminus of XRCC1 interacts with POLB, while the C-terminus of XRCC1 interacts with LIG3 (Kubota et al. 1996).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-110376", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110376" } ] }, { "id": "R-HSA-110380", "name": "Dissociation of LIG3:XRCC1 complex from the BER site", "equation": "", "summary": "After the base excision repair is completed, the complex of XRCC1 with LIG3 (DNA ligase 3), and POLB (DNA polymerase beta) dissociate from the repaired DNA (Kubota et al. 1997).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-110380", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-110380" } ] }, { "id": "R-HSA-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "equation": "", "summary": "DNA polymerase beta (POLB) cannot excise oxidatively damaged 5' AP (apurinic/apyrimidinic) dideoxyribose residue (5'ddRP) at the APEX1-generated single strand break (SSB). Instead, POLB incorporates the first nucleotide (dNMP) at the 3' end of the SSB, which displaces 5'ddRP (Podlutsky et al. 2001).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27695-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-111253", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111253" } ] }, { "id": "R-HSA-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "equation": "", "summary": "PNKP, a bifunctional polynucleotide phosphatase/kinase, acts as a 3' phosphatase to remove the terminal 3' phosphate group (3'Pi) at the single strand break (SSB) generated by NEIL1 or NEIL2 beta/delta lyase activity. The presence of XRCC1 is necessary for the 3'-phosphatase activity of PNKP. The removal of the 3'Pi (generating a 3'-OH) makes the DNA with the 3'-end suitable for extension by the DNA polymerase beta (POLB) (Whitehouse et al. 2001, Wiederhold et al. 2004, Das et al. 2006).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649705", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649705" } ] }, { "id": "R-HSA-5649708", "name": "NEIL1,NEIL2 recruits POLB to incised AP site", "equation": "", "summary": "DNA polymerase beta (POLB) is recruited to the AP (apurinic/apyrimidinic) site incised by the lyase activity of NEIL1 or NEIL2. The C-terminus of NEIL1 binds the N-terminus of POLB, while the N-terminus of NEIL2 is involved in the interaction with POLB (Wiederhold et al. 2004, Das et al. 2006).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649708", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649708" } ] }, { "id": "R-HSA-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "equation": "", "summary": "POLB (DNA polymerase beta) incorporates a single nucleotide to extend the PNKP-processed 3' end of the single strand break (SSB) generated by the beta/delta lyase activity of NEIL1 or NEIL2. POLB thus replaces the excised AP (apurinic/apyrimidinic) deoxyribose phosphate residue (5'dRP) (Wiederhold et al. 2004, Das et al. 2006).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649723", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649723" } ] }, { "id": "R-HSA-5649724", "name": "LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site", "equation": "", "summary": "After the completion of the base excision repair (BER), NEIL1 or NEIL2, POLB, LIG3:XRCC1 and PNKP dissociate from repaired DNA (Wiederhold et al. 2004, Das et al. 2006).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649724", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649724" } ] }, { "id": "R-HSA-5649725", "name": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)", "equation": "", "summary": "POLB (DNA polymerase beta) acts as a 5'-exonuclease to remove the abasic deoxyribose residue (5'dRP) generated by the DNA glycosylase and/or beta/delta lyase activity of NEIL1 or NEIL2, producing a single nucleotide gap at the SSB (single strand break) site (Wiederhold et al. 2004, Das et al. 2006). The NEIL1 or NEIL2-generated SSB has a 3' terminal phosphate (3'Pi).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649725", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649725" } ] }, { "id": "R-HSA-5649726", "name": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA", "equation": "", "summary": "LIG3:XRCC1, a complex of DNA ligase 3 and DNA repair protein XRCC1, is recruited to the single nucleotide gap at the SSB (single strand break) site bound by NEIL1 or NEIL2, and POLB, along with polynucleotide kinase/phosphatase PNKP. A large complex containing NEIL1 or NEIL2, PNKP, POLB, LIG3 and XRCC1 can be co-immunoprecipitated from cells undergoing NEIL1 or NEIL2-mediated base excision repair via single nucleotide replacement. NEIL1 interacts with POLB and LIG3 directly, but not with PNKP or XRCC1 (Wiederhold et al. 2004, Das et al. 2006). PNKP directly binds XRCC1, LIG3 and POLB, and the interaction with XRCC1 is essential for the 3'-phosphatase activity of PNKP (Whitehouse et al. 2001).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649726", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649726" } ] }, { "id": "R-HSA-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "equation": "", "summary": "After POLB (DNA polymerase beta) fills the single nucleotide gap created by the NEIL1 or NEIL2 and POLB-mediated excision of the apurinic/apyrimidinic (AP) site in a damaged DNA strand, LIG3 (DNA ligase 3) ligates the two DNA strand fragments at the single strand break (SSB), thus completing the base excision repair (Wiederhold et al. 2004, Das et al. 2006).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1", "Q969S2-1", "Q96FI4-1" ], "evidence": [ { "id": "R-HSA-5649734", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649734" } ] }, { "id": "R-HSA-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "equation": "", "summary": "APEX1 (APE1) bound to oxidatively damaged 5' AP (apurinic/apyrimidinic) dideoxyribose site (5'ddRP) recruits DNA polymerase beta (POLB) (Matsumoto et al. 1994, Klungland and Lindahl 1997, Bennett et al. 1997).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27695-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5649854", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649854" } ] }, { "id": "R-HSA-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "equation": "", "summary": "Homodimers and/or heterodimers of PARP1 and PARP2 bind single strand DNA (ssDNA) ends along with FEN1 (flap endonuclease), forming a ternary complex with POLB (DNA polymerase beta) and simultaneously displacing APEX1 (Prasad et al. 2001, Lavrik et al. 2001, Cistulli et al. 2004). While PARP2 is much less catalytically active than PARP1 in DNA damage-induced poly(ADP-ribosyl) (PAR) synthesis (Shieh et al. 1998, Ame et al. 1999, Fisher et al. 2007), the functional redundancy between PARP1 and PARP2 is probably important. Knockout of both PARP1 and PARP2 homologs is embryonic lethal in mice, while knockout of individual PARPs is not (Menissier de Murcia et al. 2003).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-54745" ], "output_participant_list": [ "R-HSA-50119" ], "enzyme_list": [ "Q86W56-1", "Q9UGN5-1", "P09874-1", "P27695-1", "P39748-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5649873", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649873" } ] }, { "id": "R-HSA-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "equation": "", "summary": "DNA polymerase beta (POLB) catalyzes DNA strand displacement synthesis. In this process, 2-10 nucleotides (dNMPs) are incorporated at the 3' end of the single strand break (SSB). Simultaneously, the other broken DNA strand, which contains a 5' oxidatively-damaged AP dideoxyribose phosphate residue (5'ddRP), is displaced as a flap structure. POLB-mediated DNA strand displacement synthesis is facilitated by PARP1 and/or PARP2 dimers, which bind the single strand DNA (ssDNA) ends and FEN1 (flap endonuclease) (Klungland and Lindahl 1997, Prasad et al. 2001, Lavrik et al. 2001, Liu et al. 2005).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UGN5-1", "P09874-1", "P39748-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5649883", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5649883" } ] }, { "id": "R-HSA-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "equation": "", "summary": "PARP1 or PARP2 homodimers or heterodimers, bound to single strand DNA (ssDNA), POLB and FEN1 at the single strand break (SSB), undergo progressive auto-PARylation causing PARP1/PARP2 to become poly(ADP-ribosyl)ated (Satoh et al. 1994, Prasad et al. 2001).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UGN5-1", "P09874-1", "P39748-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5651723", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651723" } ] }, { "id": "R-HSA-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "equation": "", "summary": "Auto-PARylated (poly(ADP-ribosylated)) PARP1 or PARP2 homodimers and heterodimers dissociate from DNA at single strand breaks (SSBs). The dissociation of PARP1 and/or PARP2 is necessary for completion of the long patch base excision repair (BER). In the presence of PARP inhibitors, PARP1 and/or PARP2 cannot auto-PARylate and remain bound to SSBs. This leads to persistence of SSBs, and generation of double strand breaks (DSBs) during DNA replication (Creissen and Shall 1982, Sukhanova et al. 2004, Sukhanova et al. 2005, Pachkowski et al. 2009, Heacock et al. 2010, Strom et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UGN5-1", "P09874-1", "P39748-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5651739", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651739" } ] }, { "id": "R-HSA-5651773", "name": "LIG1 binds POLB at long-patch BER site", "equation": "", "summary": "DNA ligase I (LIG1) binds DNA polymerase beta (POLB) at the long-patch base excision repair (BER) site. LIG1 and POLB interact through their N-terminal domains (Prasad et al. 1996, Dimitriadis et al. 1998, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18858-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5651773", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651773" } ] }, { "id": "R-HSA-5651782", "name": "FEN1 bound to POLB cleaves displaced DNA strand (flap)", "equation": "", "summary": "POLB-bound FEN1 (flap endonuclease) cleaves the displaced DNA strand (flap structure), which contains the damaged AP residue that could not be excised by POLB (DNA polymerase beta) (Klungland and Lindahl 1997, Prasad et al. 2001, Liu et al. 2005).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P39748-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5651782", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651782" } ] }, { "id": "R-HSA-5651789", "name": "LIG1 bound to POLB ligates SSB", "equation": "", "summary": "LIG1 (DNA ligase I), recruited to the long-patch base excision repair site through its interaction with POLB, ligates the 3' end of the single strand break (SSB), containing the newly synthesized multiple nucleotide repair patch, with the FEN1-processed 5' end of the SSB, thus completing the base excision repair (Prigent et al. 1994, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18858-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5651789", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651789" } ] }, { "id": "R-HSA-5651792", "name": "LIG1 and POLB dissociate from repaired dsDNA", "equation": "", "summary": "After the POLB-dependent long patch base excision (BER) is completed, POLB and LIG1 dissociate from repaired DNA (Ranalli et al. 2002).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18858-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5651792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5651792" } ] }, { "id": "R-HSA-5696947", "name": "USP47 deubiquitinates POLB", "equation": "", "summary": "USP47 specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), increasing its stability and thereby playing a role in base-excision repair (Parsons et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q96K76-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-5696947", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5696947" } ] }, { "id": "R-HSA-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "equation": "", "summary": "After POLB (DNA polymerase beta) fills a single nucleotide gap created by the APEX1 and POLB-mediated excision of the apurinic/apyrimidinic (AP) site in the damaged DNA strand, LIG3 (DNA ligase 3), recruited to POLB-bound AP site by XRCC1, ligates the two DNA strand fragments, thus completing the base excision repair (Kubota et al. 1996).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-73931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-73931" } ] }, { "id": "R-HSA-73932", "name": "Resynthesis of excised residue by POLB", "equation": "", "summary": "POLB (DNA polymerase beta) mediates DNA synthesis that fills the gap left after excision of the abasic sugar-phosphate residue, using the undamaged strand as a template (Kubota et al. 1996).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49916-1", "P06746-1" ], "evidence": [ { "id": "R-HSA-73932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-73932" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-50119", "participant_name": "APEX1 [nucleoplasm]", "crossref": [ { "id": "NP_542380.1", "database": "RefSeq", "url": "" }, { "id": "5WN1", "database": "PDB", "url": "" }, { "id": "1CQH", "database": "PDB", "url": "" }, { "id": "NP_542379.1", "database": "RefSeq", "url": "" }, { "id": "7SUV", "database": "PDB", "url": "" }, { "id": "5WN5", "database": "PDB", "url": "" }, { "id": "6W3Q", "database": "PDB", "url": "" }, { "id": "6MK3", "database": "PDB", "url": "" }, { "id": "ENSG00000100823", "database": "Ensembl", "url": "" }, { "id": "7MCR", "database": "PDB", "url": "" }, { "id": "5DFJ", "database": "PDB", "url": "" }, { "id": "7LPI", "database": "PDB", "url": "" }, { "id": "6W3U", "database": "PDB", "url": "" }, { "id": "P27695", "database": "GeneCards", "url": "" }, { "id": "5WN2", "database": "PDB", "url": "" }, { "id": "7SVB", "database": "PDB", "url": "" }, { "id": "6W4I", "database": "PDB", "url": "" }, { "id": "7TC3", "database": "PDB", "url": "" }, { "id": "NP_001632.2", "database": "RefSeq", "url": "" }, { "id": "ENST00000398030", "database": "Ensembl", "url": "" }, { "id": "APEX1_HUMAN", "database": "ZINC - Biogenic", "url": "" }, { "id": "NP_001231178.1", "database": "RefSeq", "url": "" }, { "id": "1HD7", "database": "PDB", "url": "" }, { "id": "6BOW", "database": "PDB", "url": "" }, { "id": "ENSP00000381111", "database": "Ensembl", "url": "" }, { "id": "2ISI", "database": "PDB", "url": "" }, { "id": "1BIX", "database": "PDB", "url": "" }, { "id": "7TC2", "database": "PDB", "url": "" }, { "id": "7MEV", "database": "PDB", "url": "" }, { "id": "1DE9", "database": "PDB", "url": "" }, { "id": "6BOS", "database": "PDB", "url": "" }, { "id": "6MKO", "database": "PDB", "url": "" }, { "id": "5DG0", "database": "PDB", "url": "" }, { "id": "6BOV", "database": "PDB", "url": "" }, { "id": "5WN0", "database": "PDB", "url": "" }, { "id": "6BOU", "database": "PDB", "url": "" }, { "id": "7U50", "database": "PDB", "url": "" }, { "id": "6P93", "database": "PDB", "url": "" }, { "id": "2O3H", "database": "PDB", "url": "" }, { "id": "5WN3", "database": "PDB", "url": "" }, { "id": "3U8U", "database": "PDB", "url": "" }, { "id": "ENST00000216714", "database": "Ensembl", "url": "" }, { "id": "5CFG", "database": "PDB", "url": "" }, { "id": "P27695", "database": "UniProt", "url": "" }, { "id": "1E9N", "database": "PDB", "url": "" }, { "id": "7LPJ", "database": "PDB", "url": "" }, { "id": "ENSP00000451979", "database": "Ensembl", "url": "" }, { "id": "HMDBP10647", "database": "HMDB Protein", "url": "" }, { "id": "3.1.11.2", "database": "IntEnz", "url": "" }, { "id": "ENSP00000216714", "database": "Ensembl", "url": "" }, { "id": "4QH9", "database": "PDB", "url": "" }, { "id": "ENSG00000100823", "database": "OpenTargets", "url": "" }, { "id": "6BOT", "database": "PDB", "url": "" }, { "id": "APEX1_HUMAN", "database": "ZINC - Substances", "url": "" }, { "id": "1CQG", "database": "PDB", "url": "" }, { "id": "4QHD", "database": "PDB", "url": "" }, { "id": "5WN4", "database": "PDB", "url": "" }, { "id": "APEX1_HUMAN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "1DEW", "database": "PDB", "url": "" }, { "id": "5DFI", "database": "PDB", "url": "" }, { "id": "P27695", "database": "PRO", "url": "" }, { "id": "APEX1_HUMAN", "database": "ZINC - World Drugs", "url": "" }, { "id": "4IEM", "database": "PDB", "url": "" }, { "id": "6W3L", "database": "PDB", "url": "" }, { "id": "6MKM", "database": "PDB", "url": "" }, { "id": "1DE8", "database": "PDB", "url": "" }, { "id": "5DFF", "database": "PDB", "url": "" }, { "id": "7TR7", "database": "PDB", "url": "" }, { "id": "4LND", "database": "PDB", "url": "" }, { "id": "6W0Q", "database": "PDB", "url": "" }, { "id": "5DFH", "database": "PDB", "url": "" }, { "id": "6W43", "database": "PDB", "url": "" }, { "id": "APEX1_HUMAN", "database": "ZINC - Metabolites", "url": "" }, { "id": "ENSG00000100823-APEX1", "database": "HPA", "url": "" }, { "id": "ENST00000555414", "database": "Ensembl", "url": "" }, { "id": "4QHE", "database": "PDB", "url": "" }, { "id": "6BOQ", "database": "PDB", "url": "" }, { "id": "6W2P", "database": "PDB", "url": "" }, { "id": "6W4T", "database": "PDB", "url": "" }, { "id": "P27695", "database": "ZINC target", "url": "" }, { "id": "6BOR", "database": "PDB", "url": "" }, { "id": "6MKK", "database": "PDB", "url": "" }, { "id": "6W3N", "database": "PDB", "url": "" }, { "id": "7LPH", "database": "PDB", "url": "" }, { "id": "P27695", "database": "Pharos - Targets", "url": "" }, { "id": "7LPG", "database": "PDB", "url": "" }, { "id": "6P94", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-53845", "participant_name": "POLB [nucleoplasm]", "crossref": [ { "id": "7S9M", "database": "PDB", "url": "" }, { "id": "6U6B", "database": "PDB", "url": "" }, { "id": "4R65", "database": "PDB", "url": "" }, { "id": "3TFS", "database": "PDB", "url": "" }, { "id": "5WNX", "database": "PDB", "url": "" }, { "id": "1ZQT", "database": "PDB", "url": "" }, { "id": "6CTV", "database": "PDB", "url": "" }, { "id": "9ICC", "database": "PDB", "url": "" }, { "id": "4YMN", "database": "PDB", "url": "" }, { "id": "5TBB", "database": "PDB", "url": "" }, { "id": "ENST00000265421", "database": "Ensembl", "url": "" }, { "id": "9ICW", "database": "PDB", "url": "" }, { "id": "3RJH", "database": "PDB", "url": "" }, { "id": "4PGY", "database": "PDB", "url": "" }, { "id": "3JPN", "database": "PDB", "url": "" }, { "id": "6CR9", "database": "PDB", "url": "" }, { "id": "4KLE", "database": "PDB", "url": "" }, { "id": "7ICP", "database": "PDB", "url": "" }, { "id": "NP_002681.1", "database": "RefSeq", "url": "" }, { "id": "8ICM", "database": "PDB", "url": "" }, { "id": "6N2S", "database": "PDB", "url": "" }, { "id": "3JPT", "database": "PDB", "url": "" }, { "id": "7MZ8", "database": "PDB", "url": "" }, { "id": "5DBC", "database": "PDB", "url": "" }, { "id": "5V1I", "database": "PDB", "url": "" }, { "id": "1ZQC", "database": "PDB", "url": "" }, { "id": "4M9G", "database": "PDB", "url": "" }, { "id": "2PXI", "database": "PDB", "url": "" }, { "id": "6CLY", "database": "PDB", "url": "" }, { "id": "4MFC", "database": "PDB", "url": "" }, { "id": "7ICH", "database": "PDB", "url": "" }, { "id": "5BOM", "database": "PDB", "url": "" }, { "id": "8ICE", "database": "PDB", "url": "" }, { "id": "6E3R", "database": "PDB", "url": "" }, { "id": "4RQ3", "database": "PDB", "url": "" }, { "id": "7ICU", "database": "PDB", "url": "" }, { "id": "4F5Q", "database": "PDB", "url": "" }, { "id": "5U8I", "database": "PDB", "url": "" }, { "id": "1MQ2", "database": "PDB", "url": "" }, { "id": "6CTM", "database": "PDB", "url": "" }, { "id": "7RBK", "database": "PDB", "url": "" }, { "id": "4UB2", "database": "PDB", "url": "" }, { "id": "6NKX", "database": "PDB", "url": "" }, { "id": "4KLO", "database": "PDB", "url": "" }, { "id": "5VRX", "database": "PDB", "url": "" }, { "id": "1ZQL", "database": "PDB", "url": "" }, { "id": "4NXZ", "database": "PDB", "url": "" }, { "id": "9ICO", "database": "PDB", "url": "" }, { "id": "3LK9", "database": "PDB", "url": "" }, { "id": "5J2G", "database": "PDB", "url": "" }, { "id": "5J0S", "database": "PDB", "url": "" }, { "id": "8ICU", "database": "PDB", "url": "" }, { "id": "4M9N", "database": "PDB", "url": "" }, { "id": "2I9G", "database": "PDB", "url": "" }, { "id": "6BEL", "database": "PDB", "url": "" }, { "id": "P06746", "database": "PRO", "url": "" }, { "id": "6W2M", "database": "PDB", "url": "" }, { "id": "4Z6D", "database": "PDB", "url": "" }, { "id": "7S9Q", "database": "PDB", "url": "" }, { "id": "6CUA", "database": "PDB", "url": "" }, { "id": "4RPZ", "database": "PDB", "url": "" }, { 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"https://www.uniprot.org/uniprot/D3ZKJ8" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "D3ZKJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZKJ8" } ] } ] }, { "uniprot_ac": "D3ZVH2", "gene_name": "RGD1560831", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "D3ZVH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVH2" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "D3ZVH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVH2" } ] } ] }, { "uniprot_ac": "D4A4E8", "gene_name": "Nthl1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "D4A4E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A4E8" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "D4A4E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A4E8" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "D4A4E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A4E8" } ] } ] }, { "uniprot_ac": "E9PT58", "gene_name": "Dntt", "activity": [ { "ec_number": "2.7.7.31", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "E9PT58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT58" } ] }, { "ec_number": "2.7.7.31", "activity": "", "evidence": [ { "id": "E9PT58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT58" } ] } ] }, { "uniprot_ac": "F1M8G6", "gene_name": "Rev3l", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "F1M8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8G6" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "F1M8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8G6" } ] } ] }, { "uniprot_ac": "F7F6Z7", "gene_name": "Polm", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "F7F6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F6Z7" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "F7F6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F6Z7" } ] } ] }, { "uniprot_ac": "O00370", "gene_name": "", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O00370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00370" } ] }, { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "O00370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00370" } ] } ] }, { "uniprot_ac": "O08760", "gene_name": "Ogg1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "O08760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08760" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "O08760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08760" } ] } ] }, { "uniprot_ac": "O13527", "gene_name": "TY1B-A", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13527" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "O13527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13527" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13527" } ] } ] }, { "uniprot_ac": "O13535", "gene_name": "TY1B-H", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] } ] }, { "uniprot_ac": "O14746", "gene_name": "TERT", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O14746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14746" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "O14746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14746" } ] } ] }, { "uniprot_ac": "O15527", "gene_name": "OGG1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "O15527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15527" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "O15527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15527" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "O15527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15527" } ] } ] }, { "uniprot_ac": "O18475", "gene_name": "PolQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18475" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18475" } ] } ] }, { "uniprot_ac": "O35980", "gene_name": "Nthl1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "O35980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35980" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "O35980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35980" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "O35980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35980" } ] } ] }, { "uniprot_ac": "O54747", "gene_name": "Pold1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] } ] }, { "uniprot_ac": "O60673", "gene_name": "REV3L", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O60673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60673" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O60673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60673" } ] } ] }, { "uniprot_ac": "O70249", "gene_name": "Ogg1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "O70249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70249" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "O70249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70249" } ] } ] }, { "uniprot_ac": "O70372", "gene_name": "Tert", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O70372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70372" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "O70372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70372" } ] } ] }, { "uniprot_ac": "O75417", "gene_name": "POLQ", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] } ] }, { "uniprot_ac": "O89042", "gene_name": "Pola1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O89042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89042" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O89042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89042" } ] } ] }, { "uniprot_ac": "P04053", "gene_name": "DNTT", "activity": [ { "ec_number": "2.7.7.31", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P04053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04053" } ] }, { "ec_number": "2.7.7.31", "activity": "", "evidence": [ { "id": "P04053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04053" } ] } ] }, { "uniprot_ac": "P06746", "gene_name": "POLB", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] } ] }, { "uniprot_ac": "P06766", "gene_name": "Polb", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] } ] }, { "uniprot_ac": "P09838", "gene_name": "Dntt", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P09838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09838" } ] }, { "ec_number": "2.7.7.31", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P09838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09838" } ] }, { "ec_number": "2.7.7.31", "activity": "", "evidence": [ { "id": "P09838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09838" } ] } ] }, { "uniprot_ac": "P09874", "gene_name": "PARP1", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P09874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09874" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P09874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09874" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P09874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09874" } ] } ] }, { "uniprot_ac": "P09884", "gene_name": "POLA1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P09884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09884" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P09884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09884" } ] } ] }, { "uniprot_ac": "P0C2I2", "gene_name": "TY1B-DR5", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] } ] }, { "uniprot_ac": "P0C2I3", "gene_name": "TY1B-DR6", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] } ] }, { "uniprot_ac": "P0C2I5", "gene_name": "TY1B-LR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] } ] }, { "uniprot_ac": "P0C2I6", "gene_name": "TY1B-LR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] } ] }, { "uniprot_ac": "P0C2I9", "gene_name": "TY1B-PR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] } ] }, { "uniprot_ac": "P0C2J0", "gene_name": "TY1B-PR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] } ] }, { "uniprot_ac": "P0C2J1", "gene_name": "TY1B-PR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] } ] }, { "uniprot_ac": "P0C2J3", "gene_name": "TY2B-LR1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] } ] }, { "uniprot_ac": "P0C2J7", "gene_name": "TY4B-H", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] } ] }, { "uniprot_ac": "P0CB42", "gene_name": "Alkbh1", "activity": [ { "ec_number": "1.14.11.51", "activity": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate.", "evidence": [ { "id": "P0CB42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CB42" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P0CB42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CB42" } ] }, { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "P0CB42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CB42" } ] }, { "ec_number": "1.14.11.33", "activity": "2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate.", "evidence": [ { "id": "P0CB42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CB42" } ] } ] }, { "uniprot_ac": "P0CX63", "gene_name": "TY2B-F", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] } ] }, { "uniprot_ac": "P0CX64", "gene_name": "TY2B-GR2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] } ] }, { "uniprot_ac": "P10266", "gene_name": "ERVK-10", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P10266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10266" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P10266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10266" } ] }, { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P10266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10266" } ] } ] }, { "uniprot_ac": "P10400", "gene_name": "Pol", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P10400", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10400" } ] } ] }, { "uniprot_ac": "P11369", "gene_name": "Pol", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P11369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11369" } ] }, { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "P11369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11369" } ] } ] }, { "uniprot_ac": "P13382", "gene_name": "POL1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P13382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13382" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P13382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13382" } ] } ] }, { "uniprot_ac": "P14284", "gene_name": "REV3", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P14284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14284" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P14284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14284" } ] } ] }, { "uniprot_ac": "P15436", "gene_name": "POL3", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P15436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15436" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P15436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15436" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P15436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15436" } ] } ] }, { "uniprot_ac": "P15801", "gene_name": "MIP1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P15801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15801" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P15801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15801" } ] } ] }, { "uniprot_ac": "P18858", "gene_name": "LIG1", "activity": [ { "ec_number": "6.5.1.1", "activity": "ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.", "evidence": [ { "id": "P18858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18858" } ] }, { "ec_number": "6.5.1.1", "activity": "", "evidence": [ { "id": "P18858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18858" } ] } ] }, { "uniprot_ac": "P21951", "gene_name": "POL2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P21951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21951" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P21951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21951" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P21951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21951" } ] } ] }, { "uniprot_ac": "P23396", "gene_name": "RPS3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P23396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23396" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "P23396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23396" } ] } ] }, { "uniprot_ac": "P25384", "gene_name": "TY2B-C", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P25384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25384" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P25384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25384" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P25384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25384" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P25384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25384" } ] } ] }, { "uniprot_ac": "P25615", "gene_name": "POL4", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P25615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25615" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P25615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25615" } ] } ] }, { "uniprot_ac": "P26019", "gene_name": "PolA1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P26019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26019" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P26019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26019" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P26019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26019" } ] } ] }, { "uniprot_ac": "P27695", "gene_name": "APEX1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P27695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27695" } ] }, { "ec_number": "3.1.11.2", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "P27695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27695" } ] }, { "ec_number": "3.1.11.2", "activity": "", "evidence": [ { "id": "P27695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27695" } ] } ] }, { "uniprot_ac": "P28340", "gene_name": "POLD1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P28340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28340" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P28340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28340" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P28340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28340" } ] } ] }, { "uniprot_ac": "P31378", "gene_name": "NTG1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P31378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31378" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "P31378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31378" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "P31378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31378" } ] } ] }, { "uniprot_ac": "P33609", "gene_name": "Pola1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P33609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33609" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P33609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33609" } ] } ] }, { "uniprot_ac": "P39748", "gene_name": "FEN1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P39748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39748" } ] } ] }, { "uniprot_ac": "P39985", "gene_name": "POL5", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P39985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39985" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P39985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39985" } ] } ] }, { "uniprot_ac": "P46957", "gene_name": "POL31", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P46957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46957" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P46957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46957" } ] } ] }, { "uniprot_ac": "P47024", "gene_name": "TY4B-J", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] } ] }, { "uniprot_ac": "P47098", "gene_name": "TY1B-JR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] } ] }, { "uniprot_ac": "P47100", "gene_name": "TY1B-JR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] } ] }, { "uniprot_ac": "P49916", "gene_name": "LIG3", "activity": [ { "ec_number": "6.5.1.1", "activity": "ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.", "evidence": [ { "id": "P49916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49916" } ] }, { "ec_number": "6.5.1.1", "activity": "", "evidence": [ { "id": "P49916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49916" } ] } ] }, { "uniprot_ac": "P52431", "gene_name": "Pold1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P52431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52431" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P52431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52431" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52431" } ] } ] }, { "uniprot_ac": "P53397", "gene_name": "OGG1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "P53397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53397" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P53397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53397" } ] } ] }, { "uniprot_ac": "P54098", "gene_name": "POLG", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P54098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54098" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P54098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54098" } ] } ] }, { "uniprot_ac": "P54099", "gene_name": "Polg", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P54099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54099" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P54099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54099" } ] } ] }, { "uniprot_ac": "P54358", "gene_name": "PolD1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P54358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54358" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P54358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54358" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P54358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54358" } ] } ] }, { "uniprot_ac": "P62908", "gene_name": "Rps3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P62908", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62908" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "P62908", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62908" } ] } ] }, { "uniprot_ac": "P62909", "gene_name": "Rps3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P62909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62909" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "P62909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62909" } ] } ] }, { "uniprot_ac": "P63128", "gene_name": "ERVK-9", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] }, { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] } ] }, { "uniprot_ac": "P63132", "gene_name": "HERVK_113", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63132" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63132" } ] } ] }, { "uniprot_ac": "P63133", "gene_name": "ERVK-8", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63133" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63133" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63133" } ] } ] }, { "uniprot_ac": "P63135", "gene_name": "ERVK-7", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63135" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63135" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63135" } ] } ] }, { "uniprot_ac": "P63136", "gene_name": "ERVK-25", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63136" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63136" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63136" } ] } ] }, { "uniprot_ac": "P78549", "gene_name": "NTHL1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P78549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78549" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "P78549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78549" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "P78549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78549" } ] } ] }, { "uniprot_ac": "Q03434", "gene_name": "TY1B-ML2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] } ] }, { "uniprot_ac": "Q03494", "gene_name": "TY2B-DR2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] } ] }, { "uniprot_ac": "Q03612", "gene_name": "TY1B-ER1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] } ] }, { "uniprot_ac": "Q03619", "gene_name": "TY1B-ER2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] } ] }, { "uniprot_ac": "Q03855", "gene_name": "TY1B-DR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] } ] }, { "uniprot_ac": "Q04049", "gene_name": "RAD30", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04049" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q04049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04049" } ] } ] }, { "uniprot_ac": "Q04214", "gene_name": "TY1B-MR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] } ] }, { "uniprot_ac": "Q04670", "gene_name": "TY1B-MR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] } ] }, { "uniprot_ac": "Q04711", "gene_name": "TY1B-ML1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] } ] }, { "uniprot_ac": "Q06163", "gene_name": "EST2", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q06163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06163" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "Q06163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06163" } ] } ] }, { "uniprot_ac": "Q07791", "gene_name": "TY2B-DR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] } ] }, { "uniprot_ac": "Q07793", "gene_name": "TY1B-DR4", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] } ] }, { "uniprot_ac": "Q07864", "gene_name": "POLE", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07864", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07864" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q07864", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07864" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q07864", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07864" } ] } ] }, { "uniprot_ac": "Q08214", "gene_name": "NTG2", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q08214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08214" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q08214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08214" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q08214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08214" } ] } ] }, { "uniprot_ac": "Q12088", "gene_name": "TY1B-LR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] } ] }, { "uniprot_ac": "Q12112", "gene_name": "TY1B-NL1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] } ] }, { "uniprot_ac": "Q12113", "gene_name": "TY2B-OR1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] } ] }, { "uniprot_ac": "Q12141", "gene_name": "TY1B-GR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] } ] }, { "uniprot_ac": "Q12193", "gene_name": "TY1B-BR", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] } ] }, { "uniprot_ac": "Q12269", "gene_name": "TY1B-GR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] } ] }, { "uniprot_ac": "Q12273", "gene_name": "TY1B-OL", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] } ] }, { "uniprot_ac": "Q12316", "gene_name": "TY1B-GR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] } ] }, { "uniprot_ac": "Q12414", "gene_name": "TY1B-PL", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] } ] }, { "uniprot_ac": "Q12472", "gene_name": "TY2B-DR1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] } ] }, { "uniprot_ac": "Q12490", "gene_name": "TY1B-BL", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] } ] }, { "uniprot_ac": "Q12491", "gene_name": "TY2B-B", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] } ] }, { "uniprot_ac": "Q12501", "gene_name": "TY2B-OR2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] } ] }, { "uniprot_ac": "Q13686", "gene_name": "ALKBH1", "activity": [ { "ec_number": "1.14.11.51", "activity": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate.", "evidence": [ { "id": "Q13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13686" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13686" } ] }, { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "Q13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13686" } ] }, { "ec_number": "1.14.11.33", "activity": "2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate.", "evidence": [ { "id": "Q13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13686" } ] } ] }, { "uniprot_ac": "Q1ZXF2", "gene_name": "polB", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q1ZXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXF2" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q1ZXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXF2" } ] } ] }, { "uniprot_ac": "Q27607", "gene_name": "PolG1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q27607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27607" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q27607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27607" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q27607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27607" } ] } ] }, { "uniprot_ac": "Q54B44", "gene_name": "", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q54B44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B44" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "Q54B44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B44" } ] } ] }, { "uniprot_ac": "Q54CZ3", "gene_name": "ogg1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q54CZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CZ3" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q54CZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CZ3" } ] } ] }, { "uniprot_ac": "Q54N97", "gene_name": "pold1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q54N97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N97" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q54N97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N97" } ] } ] }, { "uniprot_ac": "Q54RD4", "gene_name": "pole", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q54RD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RD4" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q54RD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RD4" } ] } ] }, { "uniprot_ac": "Q54SV8", "gene_name": "pola1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q54SV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54SV8" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q54SV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54SV8" } ] } ] }, { "uniprot_ac": "Q55AZ3", "gene_name": "polZ", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q55AZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AZ3" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q55AZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AZ3" } ] } ] }, { "uniprot_ac": "Q5RKI3", "gene_name": "Poll", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q5RKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RKI3" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "Q5RKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RKI3" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q5RKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RKI3" } ] } ] }, { "uniprot_ac": "Q61493", "gene_name": "Rev3l", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q61493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q61493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61493" } ] } ] }, { "uniprot_ac": "Q673L6", "gene_name": "Tert", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q673L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q673L6" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "Q673L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q673L6" } ] } ] }, { "uniprot_ac": "Q6R2P8", "gene_name": "Neil2", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q6R2P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6R2P8" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q6R2P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6R2P8" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q6R2P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6R2P8" } ] } ] }, { "uniprot_ac": "Q6R3M4", "gene_name": "Poli", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q6R3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6R3M4" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q6R3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6R3M4" } ] } ] }, { "uniprot_ac": "Q7LHG5", "gene_name": "TY3B-I", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q7LHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7LHG5" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q7LHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7LHG5" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q7LHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7LHG5" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q7LHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7LHG5" } ] } ] }, { "uniprot_ac": "Q7TQ07", "gene_name": "Poln", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q7TQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TQ07" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q7TQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TQ07" } ] } ] }, { "uniprot_ac": "Q7Z5Q5", "gene_name": "POLN", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q7Z5Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5Q5" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q7Z5Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5Q5" } ] } ] }, { "uniprot_ac": "Q86K43", "gene_name": "NTH1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q86K43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86K43" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q86K43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86K43" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q86K43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86K43" } ] } ] }, { "uniprot_ac": "Q86W56", "gene_name": "PARG", "activity": [ { "ec_number": "3.2.1.143", "activity": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose.", "evidence": [ { "id": "Q86W56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W56" } ] }, { "ec_number": "3.2.1.143", "activity": "", "evidence": [ { "id": "Q86W56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W56" } ] } ] }, { "uniprot_ac": "Q8CGS6", "gene_name": "Polq", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q8CGS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGS6" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q8CGS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGS6" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q8CGS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGS6" } ] } ] }, { "uniprot_ac": "Q8K203", "gene_name": "Neil3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q8K203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K203" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q8K203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K203" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q8K203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K203" } ] } ] }, { "uniprot_ac": "Q8K409", "gene_name": "Polb", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q8K409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K409" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q8K409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K409" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "Q8K409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K409" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q8K409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K409" } ] } ] }, { "uniprot_ac": "Q8K4Q6", "gene_name": "Neil1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q8K4Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4Q6" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q8K4Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4Q6" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q8K4Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4Q6" } ] } ] }, { "uniprot_ac": "Q8TAT5", "gene_name": "NEIL3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q8TAT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TAT5" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q8TAT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TAT5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q8TAT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TAT5" } ] } ] }, { "uniprot_ac": "Q92393", "gene_name": "TY1B-OR", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q92393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92393" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q92393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92393" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q92393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92393" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q92393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92393" } ] } ] }, { "uniprot_ac": "Q969S2", "gene_name": "NEIL2", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q969S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969S2" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q969S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969S2" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q969S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969S2" } ] } ] }, { "uniprot_ac": "Q96FI4", "gene_name": "NEIL1", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q96FI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96FI4" } ] }, { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q96FI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96FI4" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q96FI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96FI4" } ] } ] }, { "uniprot_ac": "Q96K76", "gene_name": "USP47", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q96K76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96K76" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q96K76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96K76" } ] } ] }, { "uniprot_ac": "Q99231", "gene_name": "TY1B-DR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q99231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99231" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q99231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99231" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q99231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99231" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q99231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99231" } ] } ] }, { "uniprot_ac": "Q99315", "gene_name": "TY3B-G", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q99315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99315" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q99315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99315" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q99315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99315" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q99315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99315" } ] } ] }, { "uniprot_ac": "Q99337", "gene_name": "TY1B-NL2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q99337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99337" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q99337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99337" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q99337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99337" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q99337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99337" } ] } ] }, { "uniprot_ac": "Q9BXR3", "gene_name": "ERVK-6", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9BXR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXR3" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q9BXR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXR3" } ] }, { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "Q9BXR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXR3" } ] } ] }, { "uniprot_ac": "Q9GSR1", "gene_name": "PolZ1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9GSR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9GSR1" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9GSR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9GSR1" } ] } ] }, { "uniprot_ac": "Q9JIW4", "gene_name": "Polm", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9JIW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIW4" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9JIW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIW4" } ] } ] }, { "uniprot_ac": "Q9JJN0", "gene_name": "Polh", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9JJN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJN0" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9JJN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJN0" } ] } ] }, { "uniprot_ac": "Q9NP87", "gene_name": "POLM", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9NP87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP87" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9NP87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP87" } ] } ] }, { "uniprot_ac": "Q9QC07", "gene_name": "ERVK-18", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "Q9QC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QC07" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9QC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QC07" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q9QC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QC07" } ] } ] }, { "uniprot_ac": "Q9QUG2", "gene_name": "Polk", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9QUG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUG2" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9QUG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUG2" } ] } ] }, { "uniprot_ac": "Q9QXE2", "gene_name": "Poll", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9QXE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXE2" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "Q9QXE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXE2" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9QXE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXE2" } ] } ] }, { "uniprot_ac": "Q9QYV8", "gene_name": "Polg", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9QYV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYV8" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9QYV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYV8" } ] } ] }, { "uniprot_ac": "Q9UBT6", "gene_name": "POLK", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q9UBT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBT6" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q9UBT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBT6" } ] } ] }, { "uniprot_ac": "Q9UGN5", "gene_name": "PARP2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9UGN5", "database": 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