{ "uniprot_canonical_ac": "P05987-1", "uniprot_ac": "P05987", "uniprot_id": "KAPR_DICDI", "mass": { "chemical_mass": 36836.0, "monoisotopic_mass": 36836.0 }, "refseq": { "ac": "XP_641686", "name": "protein kinase A regulatory subunit", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641686" }, "gene_names": [ { "name": "pkaR", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P05987", "id": "P05987" }, { "name": "DDB_G0279413", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P05987", "id": "P05987" }, { "name": "pkaR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641686", "id": "XP_641686" }, { "name": "rdeC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P05987", "id": "P05987" } ], "protein_names": [ { "name": "cAMP-dependent protein kinase regulatory subunit", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P05987" }, { "name": "Protein kinase A, regulatory subunit", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05987" }, { "name": "Rapid development protein C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05987" }, { "name": "protein kinase A regulatory subunit", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641686", "id": "XP_641686" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 30, "end_pos": 30, "sequence_org": "A", "sequence_mut": "T", "comment": "In rdeC; aggregation is followed abruptly by the maturation of spore and stalk cells. This is a due to mutation(s) in the R subunit. The mutant R subunit binds cAMP but inhibits poorly the enzymatic activity of the C subunit.", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" }, { "database": "PubMed", "id": "1312226", "url": "https://glygen.org/publication/PubMed/1312226" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "pkaR", "url": "https://www.uniprot.org/uniprot/P05987", "locus": {} } ], "crossref": [ { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0279413", "url": "http://dictybase.org/gene/DDB_G0279413", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8622094", "url": "https://www.ncbi.nlm.nih.gov/gene/8622094", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0279413", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0279413", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QILAWQK", "url": "https://omabrowser.org/oma/group/QILAWQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11635", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11635", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11635:SF152", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11635:SF152", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "http://pfam.xfam.org/family/PF00027", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P05987", "url": "http://purl.obolibrary.org/obo/PR_P05987", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_641686", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641686", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05987-1", "url": "https://www.uniprot.org/uniprot/P05987-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTNNISHNQKATEKVEAQNNNNITRKRRGAISSEPLGDKPATPLPNIPKTVETQQRLEQALSNNIMFSHLEEEERNVVFLAMVEVLYKAGDIIIKQGDEGDLFYVIDSGICDIYVCQNGGSPTLVMEVFEGGSFGELALIYGSPRAATVIARTDVRLWALNGATYRRILMDQTIKKRKLYEEFLEKVSILRHIDKYERVSLADALEPVNFQDGEVIVRQGDPGDRFYIIVEGKVVVTQETVPGDHSTSHVVSELHPSDYFGEIALLTDRPRAATVTSIGYTKCVELDRQRFNRLCGPIDQMLRRNMETYNQFLNRPPSSPNLTSQKS", "length": 327, "header": "sp|P05987-1|KAPR_DICDI Isoform 1 of cAMP-dependent protein kinase regulatory subunit OS=Dictyostelium discoideum OX=44689 GN=pkaR PE=1 SV=1 CANONICAL=P05987-1" }, "isoforms": [ { "isoform_ac": "P05987-1", "url": "", "sequence": { "sequence": "MTNNISHNQKATEKVEAQNNNNITRKRRGAISSEPLGDKPATPLPNIPKTVETQQRLEQALSNNIMFSHLEEEERNVVFLAMVEVLYKAGDIIIKQGDEGDLFYVIDSGICDIYVCQNGGSPTLVMEVFEGGSFGELALIYGSPRAATVIARTDVRLWALNGATYRRILMDQTIKKRKLYEEFLEKVSILRHIDKYERVSLADALEPVNFQDGEVIVRQGDPGDRFYIIVEGKVVVTQETVPGDHSTSHVVSELHPSDYFGEIALLTDRPRAATVTSIGYTKCVELDRQRFNRLCGPIDQMLRRNMETYNQFLNRPPSSPNLTSQKS", "length": 327, "header": "sp|P05987-1|KAPR_DICDI Isoform 1 of cAMP-dependent protein kinase regulatory subunit OS=Dictyostelium discoideum OX=44689 GN=pkaR PE=1 SV=1 CANONICAL=P05987-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "site_lbl": "Ser32" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Mutation of protein kinase A causes heterochronic development of Dictyostelium.", "journal": "Nature", "date": "1992-03-12", "authors": "Simon M N, Pelegrini O, Veron M, Kay R R", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "reference": [ { "type": "PubMed", "id": "1312226", "url": "https://glygen.org/publication/PubMed/1312226" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Cloning and cDNA sequence of the regulatory subunit of cAMP-dependent protein kinase from Dictyostelium discoideum.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Mutzel R, Lacombe M L, Simon M N, de Gunzburg J, Veron M", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "reference": [ { "type": "PubMed", "id": "3467359", "url": "https://glygen.org/publication/PubMed/3467359" } ] }, { "title": "Evidence that the RdeA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium.", "journal": "EMBO J.", "date": "1998", "authors": "Chang W T, Thomason P A, Gross J D, Neweil P C", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "reference": [ { "type": "PubMed", "id": "9582274", "url": "https://glygen.org/publication/PubMed/9582274" } ] } ], "pathway": [ { "id": "ddi:DDB_G0279413", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0279413", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "response to curcumin", "id": "GO:1904643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904643", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "regulation of protein kinase A signaling", "id": "GO:0010738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010738", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "regulation of protein phosphorylation", "id": "GO:0001932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001932", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0106070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106070", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "c-di-GMP signaling", "id": "GO:0061939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061939", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "sporulation resulting in formation of a cellular spore", "id": "GO:0030435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030435", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "culmination involved in sorocarp development", "id": "GO:0031154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031154", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "regulation of sorocarp development", "id": "GO:0031156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031156", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "regulation of sorocarp stalk cell differentiation", "id": "GO:0031285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031285", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "sorocarp morphogenesis", "id": "GO:0031288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031288", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein kinase A catalytic subunit binding", "id": "GO:0034236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034236", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase inhibitor activity", "id": "GO:0004862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004862", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase regulator activity", "id": "GO:0008603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008603", "evidence": [ { "database": "UniProtKB", "id": "P05987", "url": "https://www.uniprot.org/uniprot/P05987" } ], "pmid": "" }, { "name": "cAMP binding", "id": 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