{ "uniprot_canonical_ac": "P05388-1", "uniprot_ac": "P05388", "uniprot_id": "RLA0_HUMAN", "mass": { "chemical_mass": 34274.0, "monoisotopic_mass": 34274.0 }, "refseq": { "ac": "NP_000993", "name": "large ribosomal subunit protein uL10", "summary": "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993" }, "gene_names": [ { "name": "RPLP0", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P05388", "id": "P05388" }, { "name": "L10E; LP0; P0; PRLP0; RPP0; uL10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993", "id": "NP_000993" }, { "name": "RPLP0", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993", "id": "NP_000993" }, { "name": "hCG_2016152", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P05388", "id": "P05388" } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL10", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P05388" }, { "name": "60S acidic ribosomal protein P0", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05388" }, { "name": "60S ribosomal protein L10E", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05388" }, { "name": "acidic ribosomal phosphoprotein P0; 60S acidic ribosomal protein P0; 60S ribosomal protein L10E; ribosomal protein, large, P0; neutral ribosomal phosphoprotein P0", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993", "id": "NP_000993" }, { "name": "large ribosomal subunit protein uL10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993", "id": "NP_000993" } ], "function": [ { "annotation": "DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993" }, { "database": "PubMed", "id": "35974014", "url": "https://glygen.org/publication/PubMed/35974014" } ] }, { "annotation": "Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome.", "evidence": [ { "database": "RefSeq", "id": "NP_000993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993" }, { "database": "PubMed", "id": "32668052", "url": "https://glygen.org/publication/PubMed/32668052" } ] }, { "annotation": "Ribosomal protein P0 is the functional equivalent of E.coli protein L10.", "evidence": [ { "database": "UniProtKB", "id": "P05388", "url": "https://www.uniprot.org/uniprot/P05388#function" }, { "database": "UniProtKB", "id": "F8VWS0", "url": "https://www.uniprot.org/uniprot/F8VWS0#function" }, { "database": "UniProtKB", "id": "PIRNR039087", "url": "https://www.uniprot.org/uniprot/PIRNR039087#function" }, { "database": "UniProtKB", "id": "ARBA00002200", "url": "https://www.uniprot.org/uniprot/ARBA00002200#function" }, { "database": "UniProtKB", "id": "G3V210", "url": "https://www.uniprot.org/uniprot/G3V210#function" }, { "database": "UniProtKB", "id": "F8VRK7", "url": "https://www.uniprot.org/uniprot/F8VRK7#function" }, { "database": "UniProtKB", "id": "F8VWV4", "url": "https://www.uniprot.org/uniprot/F8VWV4#function" }, { "database": "UniProtKB", "id": "F8VQY6", "url": "https://www.uniprot.org/uniprot/F8VQY6#function" }, { "database": "UniProtKB", "id": "F8VPE8", "url": "https://www.uniprot.org/uniprot/F8VPE8#function" }, { "database": "UniProtKB", "id": "F8VW21", "url": "https://www.uniprot.org/uniprot/F8VW21#function" }, { "database": "UniProtKB", "id": "F8VZS0", "url": "https://www.uniprot.org/uniprot/F8VZS0#function" }, { "database": "UniProtKB", "id": "F8VU65", "url": "https://www.uniprot.org/uniprot/F8VU65#function" }, { "database": "UniProtKB", "id": "F8W1K8", "url": "https://www.uniprot.org/uniprot/F8W1K8#function" }, { "database": "UniProtKB", "id": "F8VS58", "url": "https://www.uniprot.org/uniprot/F8VS58#function" } ] }, { "annotation": "Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_000993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993" } ] }, { "annotation": "The presence of uL10 on the ribosomes is affected in stressed cells, thus it might be considered as a regulatory element responding to environmental fluctuations.", "evidence": [ { "database": "RefSeq", "id": "NP_000993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000993" }, { "database": "PubMed", "id": "28986221", "url": "https://glygen.org/publication/PubMed/28986221" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P05388", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05388" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 134, "end_pos": 134, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KTS->NTS).", "chr_id": "12", "chr_pos": "120198917", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "K134", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1400317877", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1400317877" }, { "id": "rs1400317877", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1400317877#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 14, "end_pos": 14, "sequence_org": "F", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NYF->NYS).", "chr_id": "12", "chr_pos": "120199457", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "F14", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P05388", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05388" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 273, "end_pos": 273, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->C).", "chr_id": "12", "chr_pos": "120196909", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "S273", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix uteri cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1251347808", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1251347808" }, { "id": "rs1251347808", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1251347808" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 273, "end_pos": 273, "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->F).", "chr_id": "12", "chr_pos": "120196909", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S273", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs768108150", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768108150" }, { "id": "rs768108150", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768108150" }, { "id": "rs768108150", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768108150" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 286, "end_pos": 286, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "12", "chr_pos": "120196870", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T286", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "99.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "99.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "99.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "99.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "99.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "99.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "99.5", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000089157" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "99.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000089157", "url": 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the 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"BioXpress", "id": "P05388", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05388" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P05388", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05388" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05388" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P05388", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05388" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"header": "tr|F8VQY6-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120198738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000547475.5", "url": "https://www.ensembl.org/id/ENST00000547475.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000450222.1", "url": "https://www.ensembl.org/id/ENSP00000450222.1" } ] } }, { "isoform_ac": "F8VRK7-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGVYCPTIIWFRVMCS", "length": 156, "header": "tr|F8VRK7-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120198727, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000551258.5", "url": "https://www.ensembl.org/id/ENST00000551258.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000448639.1", "url": "https://www.ensembl.org/id/ENSP00000448639.1" } ] } }, { "isoform_ac": "F8VS58-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKLLPVLVPLPHVKSLC", "length": 121, "header": "tr|F8VS58-1|F8VS58_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120198949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000551914.1", "url": "https://www.ensembl.org/id/ENST00000551914.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000448223.1", "url": "https://www.ensembl.org/id/ENSP00000448223.1" } ] } }, { "isoform_ac": "F8VU65-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKR", "length": 247, "header": "tr|F8VU65-1|F8VU65_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120197373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000550856.5", "url": "https://www.ensembl.org/id/ENST00000550856.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000448046.1", "url": "https://www.ensembl.org/id/ENSP00000448046.1" } ] } }, { "isoform_ac": "F8VW21-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEK", "length": 244, "header": "tr|F8VW21-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120197322, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000547211.5", "url": "https://www.ensembl.org/id/ENST00000547211.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000449854.1", "url": "https://www.ensembl.org/id/ENSP00000449854.1" } ] } }, { "isoform_ac": "F8VWS0-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 281, "header": "tr|F8VWS0-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120196776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000546989.5", "url": "https://www.ensembl.org/id/ENST00000546989.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000449205.1", "url": "https://www.ensembl.org/id/ENSP00000449205.1" } ] } }, { "isoform_ac": "F8VWV4-1", "url": "", "sequence": { "sequence": "MAFEQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPA", "length": 111, "header": "tr|F8VWV4-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200057, "end_pos": 120198944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000550423.5", "url": "https://www.ensembl.org/id/ENST00000550423.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000449765.1", "url": "https://www.ensembl.org/id/ENSP00000449765.1" } ] } }, { "isoform_ac": "F8VYN4-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIVSAGNYWMIIRNVSLWEQTMWAPSRCSRSACPFAGRLWC", "length": 57, "header": "tr|F8VYN4-1|F8VYN4_HUMAN Computationally mapped isoform of Ribosomal protein lateral stalk subunit P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=4 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120199380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000549098.5", "url": "https://www.ensembl.org/id/ENST00000549098.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000448919.1", "url": "https://www.ensembl.org/id/ENSP00000448919.1" } ] } }, { "isoform_ac": "F8VZS0-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAP", "length": 246, "header": "tr|F8VZS0-1|F8VZS0_HUMAN Computationally mapped isoform of Ribosomal protein lateral stalk subunit P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120196842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000546990.5", "url": "https://www.ensembl.org/id/ENST00000546990.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000447311.1", "url": "https://www.ensembl.org/id/ENSP00000447311.1" } ] } }, { "isoform_ac": "F8W1K8-1", "url": "", "sequence": { "sequence": "MKSSLPQGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 107, "header": "tr|F8W1K8-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120197483, "end_pos": 120196776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000552292.5", "url": "https://www.ensembl.org/id/ENST00000552292.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000446777.1", "url": "https://www.ensembl.org/id/ENSP00000446777.1" } ] } }, { "isoform_ac": "G3V210-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILVFTAPLLSGSE", "length": 166, "header": "tr|G3V210-1|RLA0_HUMAN Computationally mapped isoform of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120198738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000547173.5", "url": "https://www.ensembl.org/id/ENST00000547173.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000450019.1", "url": "https://www.ensembl.org/id/ENSP00000450019.1" } ] } }, { "isoform_ac": "P05388-1", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 317, "header": "sp|P05388-1|RLA0_HUMAN Isoform 1 of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120196776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000228306.8", "url": "https://www.ensembl.org/id/ENST00000228306.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000339027.3", "url": "https://www.ensembl.org/id/ENSP00000339027.3" } ] } }, { "isoform_ac": "P05388-2", "url": "", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 255, "header": "sp|P05388-2|RLA0_HUMAN Isoform 2 of Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1 CANONICAL=P05388-1" }, "locus": { "chromosome": "12", "start_pos": 120200783, "end_pos": 120196776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000313104.9", "url": "https://www.ensembl.org/id/ENST00000313104.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000366471.4", "url": "https://www.ensembl.org/id/ENSP00000366471.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 122, "start_aa": "Thr", "end_pos": 122, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr122", "evidence": [ { "id": "P05388", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05388" }, { "id": "27114449", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27114449" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "22121020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22121020" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 273, "start_aa": "Ser", "end_pos": 273, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser273", "evidence": [ { "id": "P05388", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05388" }, { "id": "27114449", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27114449" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "22121020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22121020" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 286, "start_aa": "Thr", "end_pos": 286, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr286", "evidence": [ { "id": "P05388", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05388" }, { "id": "27114449", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27114449" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "22121020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22121020" } ] } ], "phosphorylation": [ { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P05388", "url": "https://www.uniprot.org/uniprot/P05388" }, { "database": "iPTMnet", "id": "P05388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05388" }, { "database": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "P05388", "url": "http://phospho.elm.eu.org/byAccession/P05388.html" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" } ], "site_lbl": "Tyr24" }, { "start_pos": 273, 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